Ashok Panigrahy, Vanessa Schmithorst, Rafael Ceschin, Vince Lee, Nancy Beluk, Julia Wallace, Olivia Wheaton, Thomas Chenevert, Deqiang Qiu, James N Lee, Andrew Nencka, Borjan Gagoski, Jeffrey I Berman, Weihong Yuan, Christopher Macgowan, James Coatsworth, Lazar Fleysher, Christopher Cannistraci, Lynn A Sleeper, Arvind Hoskoppal, Candice Silversides, Rupa Radhakrishnan, Larry Markham, John F Rhodes, Lauryn M Dugan, Nicole Brown, Peter Ermis, Stephanie Fuller, Timothy Brett Cotts, Fred Henry Rodriguez, Ian Lindsay, Sue Beers, Howard Aizenstein, David C Bellinger, Jane W Newburger, Laura Glass Umfleet, Scott Cohen, Ali Zaidi, Michelle Gurvitz
Dramatic advances in the management of congenital heart disease (CHD) have improved survival to adulthood from less than 10% in the 1960s to over 90% in the current era, such that adult CHD (ACHD) patients now outnumber their pediatric counterparts. ACHD patients demonstrate domain-specific neurocognitive deficits associated with reduced quality of life that include deficits in educational attainment and social interaction. Our hypothesis is that ACHD patients exhibit vascular brain injury and structural/physiological brain alterations that are predictive of specific neurocognitive deficits modified by behavioral and environmental enrichment proxies of cognitive reserve (e...
September 6, 2023: Journal of Cardiovascular Development and Disease