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https://www.readbyqxmd.com/read/29676634/impact-of-seasonal-winter-air-pollution-on-health-across-the-lifespan-in-mongolia-and-some-putative-solutions
#1
David Warburton, Nicole Warburton, Clarence Wigfall, Ochir Chimedsuren, Delgerzul Lodoisamba, Sereeter Lodoysamba, Badarch Jargalsaikhan
Environmental pollution of the air, water, and soil comprise an increasingly urgent challenge to global health, well-being, and productivity. The impact of environmental pollution arguably has its greatest impact across the lifespan on children, women of childbearing age, and pregnant women and their unborn children, not only because of their vulnerability during development, but also because of their subsequent longevity. Ulaanbaatar, Mongolia, is a highly instructive, perhaps extreme, example of what happens with recent, rapid urbanization...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29666679/intrauterine-fetal-blood-transfusion-descriptive-study-of-the-first-four-years-experience-in-oman
#2
Arwa Z Al-Riyami, Mouza Al-Salmani, Sabria N Al-Hashami, Sabah Al-Mahrooqi, Ali Al-Marhoobi, Sumaiya Al-Hinai, Saif Al-Hosni, Sathiya M Panchatcharam, Zainab A Al-Arimi
Objectives: Haemolytic disease of the fetus and newborn (HDFN) causes hydrops fetalis . The successful treatment of HDFN has been reported with intrauterine blood transfusion (IUT). This study aimed to describe the initial experience with IUT procedures in Oman. Methods: This retrospective observational study took place at the Royal Hospital and Sultan Qaboos University Hospital Blood Bank, Muscat, Oman, and included all women who underwent IUT procedures in Oman between March 2012 and March 2016...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29616999/lncrna-uca1-is-a-novel-regulator-in-cardiomyocyte-hypertrophy-through-targeting-the-mir-184-hoxa9-axis
#3
Gaoliang Zhou, Chao Li, Jun Feng, Jing Zhang, Yanyan Fang
Cardiac hypertrophy is closely associated with a series of cardiovascular diseases, including heart failure and sudden death in particular. An in-depth comprehension of the pathogenesis of cardiac hypertrophy will improve the diagnosis and therapy of cardiac hypertrophy. It has been acknowledged that long noncoding RNAs/microRNAs (lncRNAs/miRNAs) are crucial regulators in diverse biological processes, including various cardiovascular diseases, in multiple manners. Nevertheless, the biological roles of lncRNA UCA1 and miR-184 in cardiac hypertrophy are scarcely reported...
March 20, 2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29604261/afterload-promotes-maturation-of-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-in-engineered-heart-tissues
#4
Andrea Leonard, Alessandro Bertero, Joseph D Powers, Kevin M Beussman, Shiv Bhandari, Michael Regnier, Charles E Murry, Nathan J Sniadecki
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) grown in engineered heart tissue (EHT) can be used for drug screening, disease modeling, and heart repair. However, the immaturity of hiPSC-CMs currently limits their use. Because mechanical loading increases during development and facilitates cardiac maturation, we hypothesized that afterload would promote maturation of EHTs. To test this we developed a system in which EHTs are suspended between a rigid post and a flexible one, whose resistance to contraction can be modulated by applying braces of varying length...
March 28, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29604078/maternal-undernutrition-in-late-gestation-increases-igf2-signalling-molecules-and-collagen-deposition-in-the-right-ventricle-of-the-fetal-sheep-heart
#5
Jack R T Darby, I Caroline McMillen, Janna L Morrison
Exposure of the fetus to a range of environmental stressors, including maternal undernutrition, is associated with an increased risk of death from cardiovascular disease (CVD) in adult life. This study aimed to determine the effect of maternal nutrient restriction in late gestation on the molecular mechanisms that regulate cardiac growth and development of the fetal heart. Maternal undernutrition resulted in a decrease in fetal glucose concentrations across late gestation, whilst fetal arterial PO2 remained unchanged between the control and late gestation undernutrition (LGUN) groups...
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29598826/the-complexity-of-titin-splicing-pattern-in-human-adult-skeletal-muscles
#6
Marco Savarese, Per Harald Jonson, Sanna Huovinen, Lars Paulin, Petri Auvinen, Bjarne Udd, Peter Hackman
BACKGROUND: Mutations in the titin gene (TTN) cause a large spectrum of diseases affecting skeletal and/or cardiac muscle. TTN includes 363 coding exons, a repeated region with a high degree of complexity, isoform-specific elements, and metatranscript-only exons thought to be expressed only during fetal development. Although three main classes of isoforms have been described so far, alternative splicing events (ASEs) in different tissues or in different developmental and physiological states have been reported...
March 29, 2018: Skeletal Muscle
https://www.readbyqxmd.com/read/29595875/impaired-autonomic-function-in-adolescents-born-preterm
#7
Kristin Haraldsdottir, Andrew M Watson, Kara N Goss, Arij G Beshish, David F Pegelow, Mari Palta, Laura H Tetri, Gregory P Barton, Melissa D Brix, Ryan M Centanni, Marlowe W Eldridge
Preterm birth temporarily disrupts autonomic nervous system (ANS) development, and the long-term impacts of disrupted fetal development are unclear in children. Abnormal cardiac ANS function is associated with worse health outcomes, and has been identified as a risk factor for cardiovascular disease. We used heart rate variability (HRV) in the time domain (standard deviation of RR intervals, SDRR; and root means squared of successive differences, RMSSD) and frequency domain (high frequency, HF; and low frequency, LF) at rest, as well as heart rate recovery (HRR) following maximal exercise, to assess autonomic function in adolescent children born preterm...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29582244/a-comparison-of-five-algorithms-for-fetal-magnetocardiography-signal-extraction
#8
Diana Escalona-Vargas, Hau-Tieng Wu, Martin G Frasch, Hari Eswaran
Fetal magnetocardiography (fMCG) provides accurate and reliable measurements of electrophysiological events in the fetal heart and is capable of studying fetuses with congenital heart diseases. A variety of techniques exist to extract the fMCG signal with the demand for non-invasively obtained fetal cardiac information. To the best of our knowledge, there is no comparative study published in the field as to how the various extraction algorithms perform. We perform a comparative study of the ability of five methods to extract the fMCG using real biomagnetic signals, two of those methods are applied to real fMCG data for the first time...
March 26, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29570713/maternal-fetal-and-perinatal-factors-associated-with-necrotizing-enterocolitis-in-sweden-a-national-case-control-study
#9
Margareta Ahle, Peder Drott, Anders Elfvin, Roland E Andersson
OBJECTIVE: To analyze associations of maternal, fetal, gestational, and perinatal factors with necrotizing enterocolitis in a matched case-control study based on routinely collected, nationwide register data. STUDY DESIGN: All infants born in 1987 through 2009 with a diagnosis of necrotizing enterocolitis in any of the Swedish national health care registers were identified. For each case up to 6 controls, matched for birth year and gestational age, were selected...
2018: PloS One
https://www.readbyqxmd.com/read/29570476/patent-foramen-ovale-and-hypoxemia
#10
Mohammad K Mojadidi, Juan C Ruiz, Jason Chertoff, Muhammad O Zaman, Islam Y Elgendy, Ahmed N Mahmoud, Mohammad Al-Ani, Akram Y Elgendy, Nimesh K Patel, Ghanshyam Shantha, Jonathan M Tobis, Bernhard Meier
Patent foramen ovale (PFO), an embryonic remnant of the fetal circulation, is present in 20-25% of adults. While recent observational studies and clinical trials have established the link between PFO-mediated right-to-left shunting with cryptogenic stroke and migraine with aura, the role of a PFO in exacerbating hypoxemic medical conditions (i.e., sleep apnea, chronic obstructive pulmonary disease, pulmonary hypertension, platypnea-orthodeoxia, pulmonary arteriovenous malformation, high altitude pulmonary edema, and exercise desaturation) remains poorly evaluated...
March 22, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29544375/obstetric-and-perinatal-outcomes-in-pregnancies-with-isolated-fetal-congenital-heart-abnormalities
#11
Cathy Liu, Jade Lodge, Christopher Flatley, Alexander Gooi, Cameron Ward, Karen Eagleson, Sailesh Kumar
OBJECTIVE: To determine obstetric, intrapartum and perinatal outcomes for pregnancies with isolated fetal congenital heart defects (CHD). METHODS: This was a retrospective cohort study of women that delivered an infant with an isolated major CHD between January 2010 and April 2017 at a major Australian perinatal centre. The study cohort was compared with a cohort of women with infants without CHD. Cardiac abnormalities were broadly subdivided into the following five categories using the International Classification of Diseases Tenth Revision (ICD-10) as a guide - transposition of the great arteries (TGA), septal defects, right heart lesions (RHL), left heart lesions (LHL) and "other"...
March 16, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29543795/generation-of-spatial-patterned-early-developing-cardiac-organoids-using-human-pluripotent-stem-cells
#12
Plansky Hoang, Jason Wang, Bruce R Conklin, Kevin E Healy, Zhen Ma
The creation of human induced pluripotent stem cells (hiPSCs) has provided an unprecedented opportunity to study tissue morphogenesis and organ development through 'organogenesis-in-a-dish'. Current approaches to cardiac organoid engineering rely on either direct cardiac differentiation from embryoid bodies (EBs) or generation of aligned cardiac tissues from predifferentiated cardiomyocytes from monolayer hiPSCs. To experimentally model early cardiac organogenesis in vitro, our protocol combines biomaterials-based cell patterning with stem cell organoid engineering...
April 2018: Nature Protocols
https://www.readbyqxmd.com/read/29523633/management-of-endocrine-disease-management-of-cushing-s-syndrome-during-pregnancy-solved-and-unsolved-questions
#13
Thierry Brue, Vincent Amodru, Frédéric Castinetti
With fewer than 200 reported cases, Cushing's syndrome (CS) in pregnancy remains a diagnostic and therapeutic challenge. In normal pregnancies, misleading signs may be observed such as striae or hypokalemia, while plasma cortisol and urinary free cortisol may rise up to 2-3-fold. While the dexamethasone suppression test is difficult to use, reference values for salivary cortisol appear valid. The predominant cause is adrenal adenoma (sometimes without decreased ACTH), rather than Cushing's disease. There are considerable imaging pitfalls in Cushing's disease...
March 9, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29523209/signature-of-circular-rnas-in-human-induced-pluripotent-stem-cells-and-derived-cardiomyocytes
#14
Wei Lei, Tingting Feng, Xing Fang, You Yu, Junjie Yang, Zhen-Ao Zhao, Junwei Liu, Zhenya Shen, Wenbo Deng, Shijun Hu
BACKGROUND: Circular RNAs (circRNAs) are regarded as a novel class of noncoding RNA regulators. Although a number of circRNAs have been identified by bioinformatics analysis of RNA-seq data, tissue and disease-specific circRNAs are still to be uncovered to promote their application in basic research and clinical practice. The purpose of this study was to explore the circRNA profiles in human induced pluripotent stem cells (hiPSCs) and hiPSC-derived cardiomyocytes (hiPSC-CMs), and to identify cardiac or disease-specific circRNAs...
March 9, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29518684/engineering-an-in-vitro-organotypic-model-for-studying-cardiac-hypertrophy
#15
Aditi Jain, Jafar Hasan, Perumal Arumugam Desingu, Nagalingam R Sundaresan, Kaushik Chatterjee
Neonatal cardiomyocytes cultured on flat surfaces are commonly used as a model to study cardiac failure of diverse origin. A major drawback of such a system is that the cardiomyocytes do not exhibit alignment, organization and calcium transients, similar to the native heart. Therefore, there is a need to develop in vitro platforms that recapitulate the cellular microenvironment of the murine heart as organotypic models to study cardiovascular diseases. In this study, we report an engineered platform that mimics cardiac cell organization and function of the heart...
February 27, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29502971/regulation-of-cell-cycle-to-stimulate-adult-cardiomyocyte-proliferation-and-cardiac-regeneration
#16
Tamer M A Mohamed, Yen-Sin Ang, Ethan Radzinsky, Ping Zhou, Yu Huang, Arye Elfenbein, Amy Foley, Sergey Magnitsky, Deepak Srivastava
Human diseases are often caused by loss of somatic cells that are incapable of re-entering the cell cycle for regenerative repair. Here, we report a combination of cell-cycle regulators that induce stable cytokinesis in adult post-mitotic cells. We screened cell-cycle regulators expressed in proliferating fetal cardiomyocytes and found that overexpression of cyclin-dependent kinase 1 (CDK1), CDK4, cyclin B1, and cyclin D1 efficiently induced cell division in post-mitotic mouse, rat, and human cardiomyocytes...
February 22, 2018: Cell
https://www.readbyqxmd.com/read/29485638/potential-link-between-complement-5a-receptor-and-mood-disorders-in-mouse-exposed-to-experimental-malaria-in-utero
#17
Akhabue K Okojie, O E Okobi, Hamza Dar, Hurmat Malik, Mehreen Arif, Khalid Rauf, Eghosa E Iyare
In Africa, a large number of pregnancies are exposed to Plasmodium falciparum infection. The in-utero environment extremely influences childhood neurodevelopment and behaviour. The complement 5a receptor (C5aR) is linked to several disease conditions. However, the influence of Plasmodium berghei during pregnancy on maternal complement 5a receptor and subsequently on fetal behaviour is unknown. Pregnant mice were intra-peritoneally inoculated on gestational day 13 with 1.02x105 infected red blood cells (iRBCs)...
December 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29480926/evaluation-and-management-of-maternal-congenital-heart-disease-a-review
#18
Maeve K Hopkins, Sarah A Goldstein, Cary C Ward, Jeffrey A Kuller
Objective: Congenital heart defects represent the most common major congenital anomalies. The objective of this review was to define the most common forms of congenital heart disease (CHD) in pregnancy, outline preconception counseling, discuss the associated morbidity and mortality of each lesion, and review current recommendations for management of CHD in pregnancy. Evidence Acquisition: A MEDLINE search of "congenital heart disease in pregnancy" and specific conditions in pregnancy including "ventricular septal defect," "atrial septal defect," "left outflow obstruction," "right outflow obstruction," "tetralogy of Fallot," and "transposition of the great vessels" was performed...
February 2018: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/29478779/loss-of-function-of-the-nuclear-receptor-nr2f2-encoding-coup-tf2-causes-testis-development-and-cardiac-defects-in-46-xx-children
#19
Anu Bashamboo, Caroline Eozenou, Anne Jorgensen, Joelle Bignon-Topalovic, Jean-Pierre Siffroi, Capucine Hyon, Attila Tar, Péter Nagy, Janos Sólyom, Zita Halász, Annnabel Paye-Jaouen, Sophie Lambert, David Rodriguez-Buritica, Rita Bertalan, Laetitia Martinerie, Ewa Rajpert-De Meyts, John C Achermann, Ken McElreavey
Emerging evidence from murine studies suggests that mammalian sex determination is the outcome of an imbalance between mutually antagonistic male and female regulatory networks that canalize development down one pathway while actively repressing the other. However, in contrast to testis formation, the gene regulatory pathways governing mammalian ovary development have remained elusive. We performed exome or Sanger sequencing on 79 46,XX SRY-negative individuals with either unexplained virilization or with testicular/ovotesticular disorders/differences of sex development (TDSD/OTDSD)...
February 16, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29475580/evidence-of-cardiac-involvement-in-the-fetal-inflammatory-response-syndrome-disruption-of-gene-networks-programming-cardiac-development-in-nonhuman-primates
#20
Timothy Mitchell, James W MacDonald, Sengkeo Srinouanpranchanh, Theodor K Bammler, Sean Merillat, Erica Boldenow, Michelle Coleman, Kathy Agnew, Audrey Baldessari, Jennifer E Stencel-Baerenwald, Jennifer Tisoncik-Go, Richard R Green, Michael J Gale, Lakshmi Rajagopal, Kristina M Adams Waldorf
BACKGROUND: Most early preterm births are associated with intraamniotic infection and inflammation, which can lead to systemic inflammation in the fetus. The fetal inflammatory response syndrome describes elevations in the fetal interleukin-6 level, which is a marker for inflammation and fetal organ injury. An understanding of the effects of inflammation on fetal cardiac development may lead to insight into the fetal origins of adult cardiovascular disease. OBJECTIVE: The purpose of this study was to determine whether the fetal inflammatory response syndrome is associated with disruptions in gene networks that program fetal cardiac development...
February 21, 2018: American Journal of Obstetrics and Gynecology
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