Priya Crosby, Ryan Hamnett, Marrit Putker, Nathaniel P Hoyle, Martin Reed, Carolyn J Karam, Elizabeth S Maywood, Alessandra Stangherlin, Johanna E Chesham, Edward A Hayter, Lyn Rosenbrier-Ribeiro, Peter Newham, Hans Clevers, David A Bechtold, John S O'Neill
In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting cues, adjusting internal ∼24 h rhythms to resonate with, and anticipate, external cycles of day and night. The mechanism underlying circadian entrainment to feeding time is critical for understanding why mistimed feeding, as occurs during shift work, disrupts circadian physiology, a state that is associated with increased incidence of chronic diseases such as type 2 (T2) diabetes. We show that feeding-regulated hormones insulin and insulin-like growth factor 1 (IGF-1) reset circadian clocks in vivo and in vitro by induction of PERIOD proteins, and mistimed insulin signaling disrupts circadian organization of mouse behavior and clock gene expression...
May 2, 2019: Cell