Alba de Juan, Louise Madeleine Ince, Robert Pick, Chien-Sin Chen, Filippo Molica, Gabriele Zuchtriegel, Chen Wang, Dachuan Zhang, David Druzd, Maximilian E T Hessenauer, Graziano Pelli, Isa Kolbe, Henrik Oster, Colette Prophete, Sophia Martina Hergenhan, Urs Albrecht, Jürgen Ripperger, Eloi Montanez, Christoph A Reichel, Oliver Soehnlein, Brenda R Kwak, Paul S Frenette, Christoph Scheiermann
BACKGROUND: The incidence of acute cardiovascular complications is highly time-of-day dependent. However, the mechanisms driving rhythmicity of ischemic vascular events are unknown. Although enhanced numbers of leukocytes have been linked to an increased risk of cardiovascular complications, the role that rhythmic leukocyte adhesion plays in different vascular beds has not been studied. METHODS: We evaluated leukocyte recruitment in vivo by using real-time multichannel fluorescence intravital microscopy of a tumor necrosis factor-α-induced acute inflammation model in both murine arterial and venous macrovasculature and microvasculature...
September 24, 2019: Circulation