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https://www.readbyqxmd.com/read/28731695/how-rhodopsin-tunes-the-equilibrium-between-protonated-and-deprotonated-forms-of-the-retinal-chromophore
#1
Siri Camee van Keulen, Alicia Solano, Ursula Rothlisberger
Rhodopsin is a photoactive G-protein-coupled receptor (GPCR) that converts dim light into a signal for the brain, leading to eyesight. Full activation of this GPCR is achieved after passing through several steps of the protein's photoactivation pathway. Key events of rhodopsin activation are the initial cis-trans photoisomerisation of the covalently bound retinal moiety followed by conformational rearrangements and deprotonation of the chromophore's protonated Schiff base (PSB), which ultimately lead to full activation in the meta II state...
July 21, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28730970/healthy-diet-and-reduction-of-chronic-disease-risks-of-night-shift-workers
#2
Giovanni M Ferri, Domenica Cavone, Graziana Intranuovo, Linda Macinagrossa
BACKGROUND: The large increase in epidemiological studies on night shift work is due to the important effects of night shift work on workers' health and psychophysical wellbeing. The short-term effects-insomnia, difficulties in managing work and private life, lower work performance, and more work and extra-work accidents-are easily studied. However, there are several long-term effects that are difficult to study because of the need for detailed exposure assessment and the long latency periods of these diseases...
July 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28728115/smoked-marijuana-attenuates-performance-and-mood-disruptions-during-simulated-night-shift-work
#3
Diana R Keith, Erik W Gunderson, Margaret Haney, Richard W Foltin, Carl L Hart
Individuals who work nonstandard schedules, such as rotating or night shifts, are more susceptible to workplace injuries, performance decrements, and reduced productivity. This population is also almost twice as likely to use illicit drugs as individuals working a standard day shift. The purpose of this study was to examine the effects of smoked marijuana on performance, mood, and sleep during simulated shift work. Ten experienced marijuana smokers completed this 23-day, within-participant residential study...
June 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28726267/day-length-constrains-the-time-budget-of-aphid-predators
#4
Jens Joschinski, Tim Kiess, Jochen Krauss
Phenology shifts and range expansions cause organisms to experience novel day length - temperature correlations. Depending on the temporal niche, organisms may benefit or suffer from changes in day length, thus potentially affecting phenological adaptation. We assessed the impact of day length changes on larvae of Chrysoperla carnea (Stephens) and Episyrphus balteatus (De Geer), both of which prey on aphids. Larvae of E. balteatus are night-active, whereas those of C. carnea appear to be crepuscular. We subjected both species in climate chambers to day lengths of 16 : 8 LD and, to circumvent diapause responses, 20 : 4 LD...
July 20, 2017: Insect Science
https://www.readbyqxmd.com/read/28724472/appraisal-of-the-preparedness-of-midwives-and-nurses-in-bahrain-to-conduct-early-screening-for-zika-virus-infection-in-pregnant-women
#5
Asokan G V, Mariam Mohammed Baqer Nama, Feryal Juma Salman, Zainab Habib Ali AlGhareeb, Ali Moosa Almoosawi, Ridha Abdulla Al Hammam, Muyssar Sabri Awadhalla
OBJECTIVE: To appraise the awareness and knowledge levels of midwives and nurses concerning early screening for Zika virus (ZIKV) infection among pregnant women attending health care facilities in Bahrain. METHODS: This was a cross-sectional, purposely chosen study of Bahraini and expatriate midwives, nurses, and supervisors employed in gynecology/obstetrics and labor wards of Salmanya hospital, a maternity hospital, 4 private hospitals, and health centers in Bahrain...
July 20, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28724246/health-consequences-of-electric-lighting-practices-in-the-modern-world-a-report-on-the-national-toxicology-program-s-workshop-on-shift-work-at-night-artificial-light-at-night-and-circadian-disruption
#6
REVIEW
Ruth M Lunn, David E Blask, Andrew N Coogan, Mariana G Figueiro, Michael R Gorman, Janet E Hall, Johnni Hansen, Randy J Nelson, Satchidananda Panda, Michael H Smolensky, Richard G Stevens, Fred W Turek, Roel Vermeulen, Tania Carreón, Claire C Caruso, Christina C Lawson, Kristina A Thayer, Michael J Twery, Andrew D Ewens, Sanford C Garner, Pamela J Schwingl, Windy A Boyd
The invention of electric light has facilitated a society in which people work, sleep, eat, and play at all hours of the 24-hour day. Although electric light clearly has benefited humankind, exposures to electric light, especially light at night (LAN), may disrupt sleep and biological processes controlled by endogenous circadian clocks, potentially resulting in adverse health outcomes. Many of the studies evaluating adverse health effects have been conducted among night- and rotating-shift workers, because this scenario gives rise to significant exposure to LAN...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28721785/creating-calm-amid-confrontation
#7
Bradley Squirrell
In my first year of training, I had a placement on a challenging behaviours unit for people with a learning disability. One night shift at about 11.30pm a service user, who I will call Charlotte, became physically and verbally aggressive towards staff members. This was due to an incident earlier in the day with another service user.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28712349/a-community-partnered-participatory-cluster-randomized-study-of-depression-care-quality-improvement-three-year-outcomes
#8
Michael K Ong, Loretta Jones, Wayne Aoki, Thomas R Belin, Elizabeth Bromley, Bowen Chung, Elizabeth Dixon, Megan Dwight Johnson, Felica Jones, Paul Koegel, Dmitry Khodyakov, Craig M Landry, Elizabeth Lizaola, Norma Mtume, Victoria K Ngo, Judith Perlman, Esmeralda Pulido, Vivian Sauer, Cathy D Sherbourne, Lingqi Tang, Ed Vidaurri, Yolanda Whittington, Pluscedia Williams, Aziza Lucas-Wright, Lily Zhang, Marvin Southard, Jeanne Miranda, Kenneth Wells
OBJECTIVE: Community Partners in Care, a community-partnered, cluster-randomized trial with depressed clients from 93 Los Angeles health and community programs, examined the added value of a community coalition approach (Community Engagement and Planning [CEP]) versus individual program technical assistance (Resources for Services [RS]) for implementing depression quality improvement in underserved communities. CEP was more effective than RS in improving mental health-related quality of life, reducing behavioral health hospitalizations, and shifting services toward community-based programs at six months...
July 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28707432/mechanisms-of-breast-cancer-risk-in-shift-workers-association-of-telomere-shortening-with-the-duration-and-intensity-of-night-work
#9
Johanna Samulin Erdem, Heidi Ødegaard Notø, Øivind Skare, Jenny-Anne S Lie, Marte Petersen-Øverleir, Edyta Reszka, Beata Pepłońska, Shanbeh Zienolddiny
Occupational factors such as shiftwork and especially night work that involves disruption of the circadian rhythm may contribute to increased breast cancer risk. Circadian disruption may also affect telomere length (TL). While short TL generally is associated with increased cancer risk, its association with breast cancer risk is inconclusive. We suggest that working schedules might be an important factor in assessment of effects of TL on breast cancer risk. Moreover, telomere shortening might be a potential mechanism for night work-related breast cancer...
July 14, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28707304/actigraph-measures-of-sleep-among-female-hospital-employees-working-day-or-alternating-day-and-night-shifts
#10
Jill Korsiak, Joan Tranmer, Michael Leung, Michael M Borghese, Kristan J Aronson
Sleep disturbance is common among shift workers, and may be an important factor in the effect of shift work on chronic disease development. In this cross-sectional study, we described sleep patterns of 294 female hospital workers (142 alternating day-night shift workers, 152 day workers) and determined associations between shift work and sleep duration. Rest-activity cycles were recorded with the ActiGraph GT3X+ for 1 week. Analyses were stratified by chronotype of shift workers. Using all study days to calculate average sleep duration, shift workers slept approximately 13 min less than day workers during main sleep periods, while 24-h sleep duration did not differ between day workers and shift workers...
July 14, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28707143/clinical-sleep-wake-disorders-ii-focus-on-insomnia-and-circadian-rhythm-sleep-disorders
#11
Kai Spiegelhalder, Christoph Nissen, Dieter Riemann
Insomnia and circadian rhythm sleep disorders affect large proportions of the population and have pronounced effects on quality of life and daytime performance. While the neurobiology of insomnia is not yet fully understood, circadian rhythm sleep disorders are assumed to be caused by a mismatch between the individual circadian phase position and the desired sleep-wake schedule. Benzodiazepines and non-benzodiazepine positive allosteric GABAA receptor modulators improve sleep onset and maintenance in the short-term treatment of insomnia...
July 14, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28706175/-characteristics-and-risk-factors-for-falls-in-tertiary-hospital-inpatients
#12
Eun Ju Choi, Young Shin Lee, Eun Jung Yang, Ji Hui Kim, Yeon Hee Kim, Hyeoun Ae Park
PURPOSE: The aim of this study was to explore characteristics of and risk factors for accidental inpatient falls. METHODS: Participants were classified as fallers or non-fallers based on the fall history of inpatients in a tertiary hospital in Seoul between June 2014 and May 2015. Data on falls were obtained from the fall report forms and data on risk factors were obtained from the electronic nursing records. Characteristics of fallers and non-fallers were analyzed using descriptive statistics...
June 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28698388/delayed-cryptochrome-degradation-asymmetrically-alters-the-daily-rhythm-in-suprachiasmatic-clock-neuron-excitability
#13
Sven Wegner, Mino D C Belle, Alun T L Hughes, Casey O Diekman, Hugh D Piggins
Suprachiasmatic nuclei (SCN) neurons contain an intracellular molecular circadian clock and the Cryptochromes (CRY1/2), key transcriptional repressors of this molecular apparatus, are subject to post-translational modification through ubiquitination and targeting for proteosomal degradation by the ubiquitin E3 ligase complex. Loss-of-function point mutations in a component of this ligase complex, Fbxl3, delay CRY1/2 degradation, reduce circadian rhythm strength, and lengthen the circadian period by ∼2.5h...
July 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28697155/effect-of-a-training-strategy-in-improving-medication-fallacies-during-pediatric-cardiopulmonary-resuscitation-a-before-and-after-study-from-a-developing-country
#14
Jhuma Sankar, Rashmi Ranjan Das, Samarendra Mahapatro, M Jeeva Sankar
OBJECTIVE: This study aims to evaluate the effect of structured training on resident performance in improving medication fallacies during pediatric cardiopulmonary resuscitation (CPR). METHODS: This before-and-after study was conducted in the pediatric acute care areas of tertiary care teaching hospitals of a developing country from August to December 2015. Case records of children younger than 18 years who underwent CPR were reviewed. Senior residents rotating through pediatric emergency department and pediatric intensive care unit were evaluated for their knowledge...
July 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28695685/diet-quality-and-sleep-quality-among-day-and-night-shift-nurses
#15
Deborah Beebe, Jen Jen Chang, Kathleen Kress, Mildred Mattfeldt-Beman
AIMS: To determine whether night shift workers have a poorer diet quality and sleep quality when compared with day shift nurses. BACKGROUND: There is a dearth of research investigating the association between diet quality and sleep quality of day and night shift nurses. METHODS: Data on nurses (n = 103) working either a day or night shift from two Midwestern hospitals were obtained from August 2015 to February 2016. The instruments used were the Diet History Questionnaire and the Pittsburg Sleep Quality Index...
July 11, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28693518/the-third-delay-understanding-waiting-time-for-obstetric-referrals-at-a-large-regional-hospital-in-ghana
#16
David M Goodman, Emmanuel K Srofenyoh, Adeyemi J Olufolabi, Sung Min Kim, Medge D Owen
BACKGROUND: Delay in receiving care significantly contributes to maternal morbidity and mortality. Much has been studied about reducing delays prior to arrival to referral facilities, but the delays incurred upon arrival to the hospital have not been described in many low- and middle-income countries. METHODS: We report on the obstetric referral process at Ridge Regional Hospital, Accra, Ghana, the largest referral hospital in the Ghana Health System. This study uses data from a prospectively-collected cohort of 1082 women presenting with pregnancy complications over a 10-week period...
July 11, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28692340/salivary-cortisol-and-alpha-amylase-is-there-consistency-between-psychosocial-stress-test-and-burdensome-work-shifts
#17
Kati Karhula, Mikko Härmä, Mikael Sallinen, Harri Lindholm, Ari Hirvonen, Marko Elovainio, Mika Kivimäki, Jussi Vahtera, Sampsa Puttonen
This study examined the consistency of salivary cortisol and alpha-amylase (sAA) total daily secretion between laboratory and field circumstances. The 95 participants were shift working female health care professionals with high (n = 53) or low (n = 42) psychosocial stress (job strain) measured by the Job Content Questionnaire (JCQ). The Trier Social Stress Test including a 5-minute free speech and a mental arithmetic task was conducted with four, and field measurements with three daily saliva samples of cortisol and sAA during circadian rhythm and inter-shift recovery controlled morning shift, night shift, and a day off...
July 10, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28691592/reduction-of-sleep-deprivation-and-fatigue-in-mass-transit-rail-operators
#18
Ajeenah L Haynes
Sleep and work schedules differ considerably between rail workers and the broader U.S. workforce. Due to extended work hours and night shift schedules, train and engine service workers who operate passenger trains or move freight are most vulnerable to fatigue. This article addresses the need for comprehensive fatigue risk management systems (FRMS) for rail operators. Using a transactional ergonomic perspective, FRMS are discussed with a focus on fatigue education and administrative controls to reduce feelings of tiredness, low motivation, poor concentration, and low physical activity among mass transit rail operators...
July 1, 2017: Workplace Health & Safety
https://www.readbyqxmd.com/read/28687534/over-half-of-anaesthetic-trainees-have-had-car-crash-or-near-miss-after-night-shift-survey-finds
#19
Abi Rimmer
No abstract text is available yet for this article.
July 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28681546/a-national-survey-of-the-effects-of-fatigue-on-trainees-in-anaesthesia-in-the-uk
#20
L McClelland, J Holland, J-P Lomas, N Redfern, E Plunkett
Long daytime and overnight shifts remain a major feature of working life for trainees in anaesthesia. Over the past 10 years, there has been an increase in awareness and understanding of the potential effects of fatigue on both the doctor and the patient. The Working Time Regulations (1998) implemented the European Working Time Directive into UK law, and in August 2009 it was applied to junior doctors, reducing the maximum hours worked from an average of 56 per week to 48. Despite this, there is evidence that problems with inadequate rest and fatigue persist...
July 5, 2017: Anaesthesia
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