keyword
https://read.qxmd.com/read/38538815/optimising-total-knee-replacement-imaging-a-novel-3d-printed-pet-ct-anthropomorphic-phantom-for-metal-artefact-simulation
#21
JOURNAL ARTICLE
Rajeh Assiri, Karen Knapp, Jon Fulford, Junning Chen
PURPOSE: Arthroplasty phantoms, including total knee replacement (TKR) phantoms, have been frequently used to test metal artefact reduction methods applied to positron emission tomography/computed tomography (PET/CT) images. These phantoms generally simulate either simple anatomical features or simple activity distribution around the metal inserts in the PET/CT scans. 3D printing has been used recently to fabricate fillable anthropomorphic phantoms that accurately simulate volume and geometry...
March 28, 2024: EJNMMI Physics
https://read.qxmd.com/read/38538456/advances-in-pet-imaging-of-large-vessel-vasculitis-an-update-and-future-trends
#22
REVIEW
Kornelis S M van der Geest, Olivier Gheysens, Lars C Gormsen, Andor W J M Glaudemans, Charalampos Tsoumpas, Elisabeth Brouwer, Pieter H Nienhuis, Gijs D van Praagh, Riemer H J A Slart
Systemic vasculitides are autoimmune diseases characterized by inflammation of blood vessels. They are categorized based on the size of the preferentially affected blood vessels: large-, medium-, and small-vessel vasculitides. The main forms of large-vessel vasculitis include giant cell arteritis (GCA) and Takayasu arteritis (TAK). Depending on the location of the affected vessels, various imaging modalities can be employed for diagnosis of large vessel vasculitis: ultrasonography (US), magnetic resonance angiography (MRA), computed tomography angiography (CTA), and [18 F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT)...
March 26, 2024: Seminars in Nuclear Medicine
https://read.qxmd.com/read/38538318/extranodal-nk-t-cell-lymphoma-with-localized-relapse-in-bone-marrow-of-lower-leg-detected-using-pet-ct
#23
JOURNAL ARTICLE
Takahisa Nakamura, Hiro Tatetsu, Yusuke Higuchi, Shinya Endo, Shinya Shiraishi, Koichi Kawanaka, Daisuke Imakane, Miyu Sonoda, Rie Furuta, Takafumi Shichijo, Yumi Honda, Kennosuke Karube, Yoshiki Mikami, Kisato Nosaka, Masao Matsuoka, Jun-Ichirou Yasunaga
Extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is a rare subtype of non-Hodgkin lymphoma (NHL) with poor prognosis, particularly in relapsed or refractory patients. Thus, timely detection of relapse and appropriate disease management are crucial. We present two patients with ENKTL, wherein positron emission tomography-computed tomography (PET-CT) with total-body coverage after induction therapy, detected newly relapsed regions in the bone marrow of the lower leg prior to progression. Case 1: A 47-year-old woman with nasal obstruction, showing 18F-fluoro-deoxyglucose (FDG) uptake in the nasal cavity (Lugano stage IE)...
2024: Journal of Clinical and Experimental Hematopathology: JCEH
https://read.qxmd.com/read/38537960/metabolic-tumor-volume-as-significant-predictor-for-chemotherapy-containing-pd-l1-blocker-in-extensive-stage-small-cell-lung-cancer
#24
JOURNAL ARTICLE
Kosuke Hashimoto, Kyoichi Kaira, Hisao Imai, Y U Miura, Ayako Shiono, Atsuto Mouri, O U Yamaguchi, Kunihiko Kobayashi, Hiroshi Kagamu, Ichiei Kuji
BACKGROUND/AIM: Chemo-immunotherapy, including the programmed death ligand 1 (PD-L1) antibody, is an effective treatment for patients with extensive-stage small-cell lung cancer (ES-SCLC). However, no biomarker has been established for the prediction of chemo-immunotherapy. Therefore, we investigated the potential of 18 F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) as a predictive marker. PATIENTS AND METHODS: Forty-six patients with ES-SCLC who received 18 F-FDG-PET immediately before combined platinum-based chemotherapy with PD-L1 blockade as a first-line treatment were eligible, and the maximum standard uptake value (SUVmax ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) on 18 F-FDG uptake were evaluated...
April 2024: Anticancer Research
https://read.qxmd.com/read/38537732/positron-emission-tomography-assessment-of-coronary-microvascular-angina-in-patients-with-angina-and-nonobstructive-coronary-artery-disease
#25
JOURNAL ARTICLE
Anahita Tavoosi, Amélie Paquin, Robert deKemp, Aun-Yeong Chong, Kevin Emery Boczar, Rob S B Beanlands, Thais A Coutinho
No abstract text is available yet for this article.
March 25, 2024: Journal of Nuclear Cardiology
https://read.qxmd.com/read/38537071/metabolic-tumor-burden-as-a-prognostic-indicator-after-neoadjuvant-chemotherapy-in-pancreatic-cancer
#26
JOURNAL ARTICLE
Woohyung Lee, Minyoung Oh, Jae Seung Kim, Minkyu Sung, Kwangpyo Hong, Bong Jun Kwak, Yejong Park, Eunsung Jun, Ki Byung Song, Dae Wook Hwang, Jae Hoon Lee, Changhoon Yoo, Kyu-Pyo Kim, Inkeun Park, Jae Ho Jeong, Heung-Moon Chang, Baek-Yeol Ryoo, Jung Bok Lee, Song Cheol Kim
BACKGROUND: There is no standardized assessment for evaluating response although neoadjuvant chemotherapy (NAT) is widely accepted for borderline resectable or locally advanced pancreatic cancer (BRPC or LAPC). This study was aimed to evaluate NAT response using positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG-PET/CT) parameters alongside carbohydrate antigen (CA) 19-9 levels. METHODS: Patients who underwent surgery after NAT for BRPC and LAPC between 2017 and 2021 were identified...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38536511/repeatability-of-18-f-fdg-uptake-in-metastatic-bone-lesions-of-breast-cancer-patients-and-implications-for-accrual-to-clinical-trials
#27
JOURNAL ARTICLE
Mark Muzi, Lanell M Peterson, Jennifer M Specht, Daniel S Hippe, Alena Novakova-Jiresova, Jean H Lee, Brenda F Kurland, David A Mankoff, Nancy Obuchowski, Hannah M Linden, Paul E Kinahan
BACKGROUND: Standard measures of response such as Response Evaluation Criteria in Solid Tumors are ineffective for bone lesions, often making breast cancer patients that have bone-dominant metastases ineligible for clinical trials with potentially helpful therapies. In this study we prospectively evaluated the test-retest uptake variability of 2-deoxy-2-[18F]fluoro-D-glucose (18 F-FDG) in a cohort of breast cancer patients with bone-dominant metastases to determine response criteria. The thresholds for 95% specificity of change versus no-change were then applied to a second cohort of breast cancer patients with bone-dominant metastases...
March 27, 2024: EJNMMI Research
https://read.qxmd.com/read/38535772/musculoskeletal-pitfalls-on-molecular-imaging-studies-of-oncologic-patients-how-to-stay-out-of-trouble
#28
REVIEW
Brooke Sarna, Ty Subhawong, Efrosyni Sfakianaki, Richard Wang, Anna Christodoulou-Vega, Fabiano N Cardoso
An increasing amount of molecular imaging studies are ordered each year for an oncologic population that continues to expand and increase in age. The importance of these studies in dictating further care for oncologic patients underscores the necessity of differentiating benign from malignant findings, particularly for a population in whom incidental findings are common. The aim of this review is to provide pictorial examples of benign musculoskeletal pathologies which may be found on molecular imaging and which may be mistaken for malignant processes...
March 8, 2024: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/38535200/a-phase-i-iia-prospective-randomized-open-label-study-on-the-safety-and-efficacy-of-nebulized-liposomal-amphotericin-for-invasive-pulmonary-aspergillosis
#29
JOURNAL ARTICLE
Jesús Fortún, Elia Gómez-García de la Pedrosa, Alberto Martínez-Lorca, Patricia Paredes, Pilar Martín-Dávila, Alicia Gómez-López, María José Buitrago, Javier López-Jiménez, Francesca Gioia, Rosa Escudero, Maria Elena Alvarez-Alvarez, Cruz Soriano, Javier Moreno-García, Diana San Miguel, Noelia Vicente, Santiago Moreno
Although nebulized liposomal amphotericin B (NLAB) is being used in invasive pulmonary aspergillosis (IPA) prophylaxis, no clinical trial has shown its efficacy as a therapeutic strategy. NAIFI is the inaugural randomized, controlled clinical trial designed to examine the safety and effectiveness of NLAB (dosage: 25 mg in 6 mL, three times per week for 6 weeks) against a placebo, in the auxiliary treatment of IPA. Throughout the three-year clinical trial, thirteen patients (six NLAB, seven placebo) were included, with 61% being onco-hematological with less than 100 neutrophils/μL...
March 1, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535118/cardiac-allograft-vasculopathy-challenges-and-advances-in-invasive-and-non-invasive-diagnostic-modalities
#30
REVIEW
Moaz A Kamel, Isabel G Scalia, Amro T Badr, Nima Baba Ali, Juan M Farina, Milagros Pereyra, Mohammed Tiseer Abbas, Ahmed K Mahmoud, Robert L Scott, David E Steidley, Julie L Rosenthal, Lisa M Lemond, Kristen A Sell-Dottin, Brian W Hardaway, Timothy Barry, Ming Yang, Chieh-Ju Chao, Clinton E Jokerst, Chadi Ayoub, Reza Arsanjani
Cardiac allograft vasculopathy (CAV) is a distinct form of coronary artery disease that represents a major cause of death beyond the first year after heart transplantation. The pathophysiology of CAV is still not completely elucidated; it involves progressive circumferential wall thickening of both the epicardial and intramyocardial coronary arteries. Coronary angiography is still considered the gold-standard test for the diagnosis of CAV, and intravascular ultrasound (IVUS) can detect early intimal thickening with improved sensitivity...
March 21, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38535078/comparative-review-of-the-current-and-future-strategies-to-evaluate-bone-marrow-infiltration-at-diffuse-large-b-cell-lymphoma-diagnosis
#31
REVIEW
Fernando Martin-Moro, Javier Lopez-Jimenez, Jose A Garcia-Marco, Jose A Garcia-Vela
Diffuse large B-cell lymphoma (DLBCL) requires a complete staging at diagnosis that may have prognostic and therapeutic implications. The role of bone marrow (BM) biopsy (BMB) is controversial in the era of nuclear imaging techniques. We performed a comparative review of 25 studies focused on BM evaluation at DLBCL diagnosis, including at least two of the following techniques: BMB, flow cytometry, and positron emission tomography (PET-FDG). The report about BM involvement (BMi), diagnostic accuracy, and prognostic significance was collected and compared among techniques...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38535006/current-trends-and-applications-of-pet-mri-hybrid-imaging-in-neurodegenerative-diseases-and-normal-aging
#32
REVIEW
Jonathan Lee, Jonathan Renslo, Kasen Wong, Thomas G Clifford, Bryce D Beutler, Paul E Kim, Ali Gholamrezanezhad
Dementia is a significant global health issue that is exacerbated by an aging population. Imaging plays an established role in the evaluation of patients with neurocognitive disorders such as dementia. In current clinical practice, magnetic resonance imaging (MRI) and positron emission tomography (PET) are primary imaging modalities used separately but in concert to help diagnose and classify dementia. The clinical applications of PET/MRI hybrid imaging in dementia are an active area of research, particularly given the continued emergence of functional MRI (fMRI) and amyloid PET tracers...
March 10, 2024: Diagnostics
https://read.qxmd.com/read/38534997/comparison-of-transoral-and-transcervical-ultrasonography-with-mri-for-the-diagnostic-work-up-of-oropharynx-tumors-a-protocol-for-a-multicenter-clinical-trial-spotus
#33
JOURNAL ARTICLE
Martin Garset-Zamani, Gitte Bjørn Hvilsom, Thomas Kjærgaard, Christina Caroline Plaschke, Christoffer Holst Hahn, Mikkel Kaltoft, Padraig O'Leary, Natalie Lassen Frid, Rikke Norling, Danijela Dejanovic, Johanna Maria Hall, Tina Klitmøller Agander, Signe Bergliot Nielsen, Annette Kjær Ersbøll, Irene Wessel, Christian von Buchwald, Tobias Todsen
This study protocol for a prospective, multicenter, diagnostic, clinical trial describes the integration of transoral and transcervical ultrasonography (US) in the initial clinical work-up of patients referred to tertiary head and neck cancer centers with suspected oropharyngeal cancer. The study evaluates the blinded detection rate of oropharyngeal tumors and their US-estimated size and T-stage before histopathology and cross-sectional imaging are available. Magnetic resonance imaging (MRI) scans will be prospectively rated while blinded to T-site histopathology and US...
March 8, 2024: Diagnostics
https://read.qxmd.com/read/38534501/improving-generalizability-of-pet-dl-algorithms-list-mode-reconstructions-improve-dotatate-pet-hepatic-lesion-detection-performance
#34
JOURNAL ARTICLE
Xinyi Yang, Michael Silosky, Jonathan Wehrend, Daniel V Litwiller, Muthiah Nachiappan, Scott D Metzler, Debashis Ghosh, Fuyong Xing, Bennett B Chin
Deep learning (DL) algorithms used for DOTATATE PET lesion detection typically require large, well-annotated training datasets. These are difficult to obtain due to low incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and the high cost of manual annotation. Furthermore, networks trained and tested with data acquired from site specific PET/CT instrumentation, acquisition and processing protocols have reduced performance when tested with offsite data. This lack of generalizability requires even larger, more diverse training datasets...
February 27, 2024: Bioengineering
https://read.qxmd.com/read/38532604/performance-of-the-iterative-osem-and-hyper-algorithm-for-total-body-pet-at-suvmax-with-a-low-18f-fdg-activity-a-short-acquisition-time-and-small-lesions
#35
JOURNAL ARTICLE
Keyu Zan, Yanhua Duan, Minjie Zhao, Hui Li, Xiao Cui, Leiying Chai, Zhaoping Cheng
OBJECTIVE: The primary objective of this comparative investigation was to examine the qualitative attributes of image reconstructions utilizing two distinct algorithms, namely OSEM and HYPER Iterative, in total-body 18F- FDG PET/CT under various acquisition durations and injection activities. METHODS: An initial assessment was executed using a NEMA phantom to compare image quality engendered by OSEM and HYPER Iterative algorithms. Parameters such as BV, COV, and CRC were meticulously evaluated...
March 25, 2024: Current medical imaging
https://read.qxmd.com/read/38532076/follicular-dendritic-cell-sarcoma-arising-from-the-lymph-node-of-the-pancreatic-head-a-case-report-with-literature-review
#36
JOURNAL ARTICLE
Takahiro Yamada, Keinosuke Ishido, Norihisa Kimura, Taiichi Wakiya, Hayato Nagase, Shintaro Goto, Tadashi Yoshizawa, Hiroshi Kijima, Seiichi Kato, Kenichi Hakamada
A 72-year-old man was referred to our hospital for the examination of a pancreatic head mass. Abdominal computed tomography revealed a contrasted 8-cm-diameter tumor extending from the dorsal pancreatic head to the porta hepatis. The preoperative diagnosis was challenging due to the absence of specific imaging findings and the inability to perform a biopsy. Positron emission tomography/computed tomography and diffusion-weighted imaging suggested a malignant tumor originating from the organs surrounding the pancreatic head...
March 26, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38532075/miliary-tuberculosis-diagnosed-by-diffuse-hepatic-uptake-on-pet-ct-and-transjugular-liver-biopsy
#37
JOURNAL ARTICLE
Ren Ueta, Akiko Saito, Yuka Yanai, Yuki Otake, Chizu Yokoi, Jun-Ichi Akiyama, Mikio Yanase, Tsuyoshi Tajima
The patient was an 81-year-old man. In his 20s, he had been treated with pharmacotherapy for pulmonary tuberculosis for 1 year. He presented to the Department of Respiratory Medicine with a chief complaint of dyspnea. The possibility of respiratory disease appeared to be low, but hepatic impairment was detected. The patient was thus referred to our department. Though the cause of hepatic impairment was unknown, the soluble interleukin-2 receptor level was elevated, suggesting malignant lymphoma. 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) revealed diffuse, homogenous, intense FDG uptake in the entire liver, and transjugular liver biopsy confirmed the diagnosis...
March 26, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38530487/expanding-a-peptide-covalent-probe-hybrid-for-pet-imaging-of-s-aureus-driven-focal-infections
#38
JOURNAL ARTICLE
Jyotsna Bhatt Mitra, Saurav Chatterjee, Anuj Kumar, Elina Khatoon, Ashok Chandak, Sutapa Rakshit, Anupam Bandyopadhyay, Archana Mukherjee
BACKGROUND: The urgent demand for innovative theranostic strategies to combat bacterial resistance to antibiotics is evident, with substantial implications for global health. Rapid diagnosis of life-threatening infections can expedite treatment, improving patient outcomes. Leveraging diagnostic modalities i.e., positron emission tomography (PET) and single photon emission computed tomography (SPECT) for detecting focal infections has yielded promising results. Augmenting the sensitivity of current PET and SPECT tracers could enable effective imaging of pathogenic bacteria, including drug-resistant strains...
March 26, 2024: EJNMMI Radiopharmacy and Chemistry
https://read.qxmd.com/read/38530298/comparison-of-semi-automatic-and-manual-segmentation-methods-for-tumor-delineation-on-head-and-neck-squamous-cell-carcinoma-hnscc-positron-emission-tomography-pet-images
#39
JOURNAL ARTICLE
Mahima Merin Philip, Jessica Watts, Seyedeh Niki Mir Moeini, Mohammed Musheb, Fergus McKiddie, Andy Welch, Mintu Nath
Accurate and reproducible tumor delineation on Positron Emission Tomography (PET) images is required to validate predictive and prognostic models based on PET radiomic features. Manual segmentation of tumors is time-consuming whereas semi-automatic methods are easily implementable and inexpensive. This study assessed the reliability of semi-automatic segmentation methods over manual segmentation for tumor delineation in Head and Neck Squamous Cell Carcinoma (HNSCC) PET images.

Approach: We employed manual and six semi-automatic segmentation methods (Just Enough Interaction (JEI), watershed, grow from seeds (GfS), flood filling (FF), 30% SUVmax and 40%SUVmax threshold) using 3D slicer software to extract 128 radiomic features from FDG-PET images of 100 HNSCC patients independently by three operators...
March 26, 2024: Physics in Medicine and Biology
https://read.qxmd.com/read/38529716/determination-of-lutetium-density-in-lyso-crystals-methodology-and-pet-detector-applications
#40
JOURNAL ARTICLE
T C Thien, M V Nemallapudi
Objective . Lutetium yttrium oxyorthosilicate (LYSO) scintillation crystals are used in positron emission tomography (PET) due to their high gamma attenuation, fair energy resolution, and fast scintillation decay time. The enduring presence of the176 Lu isotope, characterized by a half-life of 37.9 billion years, imparts a consistent radiation background (BG) profile that depends on the geometry and composition attributes of the LYSO crystals. Approach . In this work, we proposed a methodology for estimating the composition of LYSO crystals in cases where the exact Lutetium composition remains unknown...
March 26, 2024: Physics in Medicine and Biology
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