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https://www.readbyqxmd.com/read/27433836/identification-of-telomerase-activating-blends-from-naturally-occurring-compounds
#1
Ghania Ait-Ghezala, Samira Hassan, Miles Tweed, Daniel Paris, Gogce Crynen, Zuchra Zakirova, Stefan Crynen, Fiona Crawford
Context • Telomeres are repeated deoxyribonucleic acid (DNA) sequences (TTAGGG) that are located on the 5' ends of chromosomes, and they control the life span of eukaryotic cells. Compelling evidence has shown that the length of a person's life is dictated by the limited number of times that a human cell can divide. The enzyme telomerase has been shown to bind to and extend the length of telomeres. Thus, strategies for activating telomerase may help maintain telomere length and, thus, may lead to improved health during aging...
June 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/26950204/a-natural-product-telomerase-activator-lengthens-telomeres-in-humans-a-randomized-double-blind-and-placebo-controlled-study
#2
Laura Salvador, Gunasekaran Singaravelu, Calvin B Harley, Peter Flom, Anitha Suram, Joseph M Raffaele
TA-65 is a dietary supplement based on an improved formulation of a small molecule telomerase activator that was discovered in a systematic screening of natural product extracts from traditional Chinese medicines. This study summarizes the findings on telomere length (TL) changes from a randomized, double blind, placebo controlled study of TA-65 over a 1 year period. The study was conducted on 117 relatively healthy cytomegalovirus-positive subjects aged 53-87 years old. Subjects taking the low dose of TA-65 (250 U) significantly increased TL over the 12 months period (530 ± 180 bp; p = 0...
March 30, 2016: Rejuvenation Research
https://www.readbyqxmd.com/read/26869760/evaluation-of-an-oral-telomerase-activator-for-early-age-related-macular-degeneration-a-pilot-study
#3
Coad Thomas Dow, Calvin B Harley
PURPOSE: Telomere attrition and corresponding cellular senescence of the retinal pigment epithelium contribute to the changes of age-related macular degeneration. Activation of the enzyme telomerase can add telomeric DNA to retinal pigment epithelium chromosomal ends and has been proposed as a treatment for age-related macular degeneration. We report the use of a small molecule, oral telomerase activator (TA)-65 in early macular degeneration. This study, focusing on early macular degeneration, provides a model for the use of TAs in age-related disease...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/26387037/what-is-the-benefit-of-tranexamic-acid-vs-reinfusion-drains-in-total-joint-arthroplasty
#4
RANDOMIZED CONTROLLED TRIAL
Bryan D Springer, Susan M Odum, Thomas K Fehring
We sought to compare the efficacy and cost of reinfusion drains vs tranexamic acid (TA) in primary total joint athroplasty (TJA) patients. We randomized 186 primary TJAs (71 hips, 115 knees) to standard drains (61/186), autologous reinfusion drains (60/186), or single dose (20 mg/kg) of TA (65/186). There was a statistically significant (P < .0001) less drop in hemoglobin levels (2.98 mg/dL; range, 0.5-6.10) in the TA group compared with standard drains (P < .0001) and reinfusion drains (P < .0061)...
January 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/24709644/functional-assessment-of-pharmacological-telomerase-activators-in-human-t-cells
#5
Brenda Molgora, Riley Bateman, Greg Sweeney, Danielle Finger, Taylor Dimler, Rita B Effros, Hector F Valenzuela
Telomeres are structures at the ends of chromosomes that shorten during cell division and eventually signal an irreversible state of growth arrest known as cellular senescence. To delay this cellular aging, human T cells, which are critical in the immune control over infections and cancer, activate the enzyme telomerase, which binds and extends the telomeres. Several different extracts from the Astragalus membranaceus root have been documented to activate telomerase activity in human T cells. The objective of this research was to compare two extracts from Astragalus membranaceus, TA-65 and HTA, for their effects on both telomerase and proliferative activity of human CD4 and CD8 T cells...
2013: Cells
https://www.readbyqxmd.com/read/24480597/experimental-increase-in-telomere-length-leads-to-faster-feather-regeneration
#6
Sophie Reichert, Pierre Bize, Mathilde Arrivé, Sandrine Zahn, Sylvie Massemin, François Criscuolo
Telomeres - the protective ends of linear chromosomes - reveal themselves not only as a good proxy in terms of longevity, but more recently also as a marker of healthy ageing in laboratory rodents. Telomere erosion is prevented by the activation of telomerase, an enzyme suspected to be also vital for tissue regeneration and which experimental activation improves health state in mice. One emerging hypothesis is that telomerase activity accounts for the frequently reported positive links between telomere lengths and individual quality in a wide range of organisms...
April 2014: Experimental Gerontology
https://www.readbyqxmd.com/read/23808324/a-natural-product-telomerase-activator-as-part-of-a-health-maintenance-program-metabolic-and-cardiovascular-response
#7
Calvin B Harley, Weimin Liu, Peter L Flom, Joseph M Raffaele
A short average telomere length is associated with low telomerase activity and certain degenerative diseases. Studies in animals and with human cells confirm a causal mechanism for cell or tissue dysfunction triggered by critically short telomeres, suggesting that telomerase activation may be an approach to health maintenance. Previously, we reported on positive immune remodeling in humans taking a commercial health maintenance program, PattonProtocol-1, composed of TA-65® (a natural product-derived telomerase activator) and other dietary supplements...
October 2013: Rejuvenation Research
https://www.readbyqxmd.com/read/21426483/the-telomerase-activator-ta-65-elongates-short-telomeres-and-increases-health-span-of-adult-old-mice-without-increasing-cancer-incidence
#8
Bruno Bernardes de Jesus, Kerstin Schneeberger, Elsa Vera, Agueda Tejera, Calvin B Harley, Maria A Blasco
Here, we show that a small-molecule activator of telomerase (TA-65) purified from the root of Astragalus membranaceus is capable of increasing average telomere length and decreasing the percentage of critically short telomeres and of DNA damage in haploinsufficient mouse embryonic fibroblasts (MEFs) that harbor critically short telomeres and a single copy of the telomerase RNA Terc gene (G3 Terc(+/-) MEFs). Importantly, TA-65 does not cause telomere elongation or rescue DNA damage in similarly treated telomerase-deficient G3 Terc(-/-) littermate MEFs...
August 2011: Aging Cell
https://www.readbyqxmd.com/read/20822369/a-natural-product-telomerase-activator-as-part-of-a-health-maintenance-program
#9
Calvin B Harley, Weimin Liu, Maria Blasco, Elsa Vera, William H Andrews, Laura A Briggs, Joseph M Raffaele
Most human cells lack sufficient telomerase to maintain telomeres, hence these genetic elements shorten with time and stress, contributing to aging and disease. In January, 2007, a commercial health maintenance program, PattonProtocol-1, was launched that included a natural product-derived telomerase activator (TA-65®, 10-50 mg daily), a comprehensive dietary supplement pack, and physician counseling/laboratory tests at baseline and every 3-6 months thereafter. We report here analysis of the first year of data focusing on the immune system...
February 2011: Rejuvenation Research
https://www.readbyqxmd.com/read/19251003/narrow-band-imaging-magnification-predicts-the-histology-and-invasion-depth-of-colorectal-tumors
#10
Hiroyuki Kanao, Shinji Tanaka, Shiro Oka, Mayuko Hirata, Shigeto Yoshida, Kazuaki Chayama
BACKGROUND: There are several reports concerning the differential diagnosis of non-neoplastic and neoplastic colorectal lesions by narrow-band imaging (NBI). However, there are only a few NBI articles that assessed invasion depth. OBJECTIVE: To determine the clinical usefulness of NBI magnification for evaluating microvessel architecture in relation to pit appearances and in the qualitative diagnosis of colorectal tumors. DESIGN: A retrospective study...
March 2009: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/17165055/muscle-activation-following-sudden-ankle-inversion-during-standing-and-walking
#11
J Ty Hopkins, Todd McLoda, Steve McCaw
Dynamic response characteristics of ankle musculature following sudden ankle inversion have traditionally been tested in a static, standing position. However, this model does not take into consideration muscle activity and loading characteristics associated with active gait. This study compared muscle reaction times and amplitudes from sudden ankle inversion during standing (standing group) and walking (walking group) using one of two similar devices for each of these conditions. Surface EMG was collected from the peroneus longus (PL), brevis (PB), and tibialis anterior (TA) of the dominant leg from 25 subjects (age 20 +/- 1 years, height 174...
March 2007: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/15527447/the-fabp2-gene-polymorphism-in-cerebrovascular-disease
#12
P Wanby, P Palmquist, I Rydén, L Brattström, M Carlsson
OBJECTIVE: Earlier studies have shown that the fatty acid binding protein 2 (FABP2) T54 allele is associated with dyslipidemia, which in turn correlates with the incidence of cerebrovascular disease (CVD). To assess whether the FABP2 gene A54T polymorphism is associated with an increased risk of CVD we undertook a case-control study. MATERIALS AND METHODS: A total of 407 patients diagnosed with acute CVD and 158 control subjects were genotyped for the A54T polymorphism using a PCR-RFLP method...
December 2004: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/11765548/-clinico-pathologic-differences-between-bladder-neoplasm-with-low-malignant-potential-and-low-grade-carcinoma
#13
COMPARATIVE STUDY
J Alvarez Kindelán, A López Beltrán, F Anglada Curado, P Moreno Arcas, J L Carazo Carazo, J C Regueiro López, M Leva Vallejo, R Prieto Castro, M J Requena Tapia
OBJECTIVE: To determine if the morphologic subgrouping of grade I bladder tumors between papillary neoplasm of low malignant potential and low grade papillary carcinoma is of clinical and survival value. MATERIAL AND METHODS: All 257 consecutive patients diagnosed of superficial bladder cancer between 1990 and 1995 in HU Reina Sofia of Cordoba were reviewed and further reclassified according to WHO/ISUP consensus classification of urothelial neoplasms of the bladder...
October 2001: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/11593372/purulence-and-gram-negative-bacilli-in-tracheal-aspirates-of-mechanically-ventilated-very-low-birth-weight-infants
#14
L Cordero, M Sananes, P Dedhiya, L W Ayers
OBJECTIVE: Tracheal aspirates (TAs) from mechanically ventilated very low birth weight (VLBW) infants are frequently obtained during the evaluation of suspected sepsis, tracheitis, or ventilator-associated pneumonia (VAP). Purulence and bacteria in Gram stain of bronchopulmonary secretions are considered signs of respiratory infection, and medical decisions are made on the assumption that they are predictors of positive bacterial tracheal cultures (TCs). The purpose of this retrospective investigation was to establish the relationship of purulence and bacteria in TA from ventilated VLBW infants with positive TC and to identify its clinical significance...
September 2001: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/7926318/a-simple-effective-and-well-tolerated-treatment-regime-for-west-syndrome
#15
E Schlumberger, O Dulac
The authors systematically treated 94 patients with West syndrome using the same protocol of sodium valproate and steroids, starting with hydrocortisone (HC) orally for two weeks. If seizures stopped, HC was withdrawn; if they persisted, tetracosactrin (TA; synthetic ACTH) was administered for another two weeks then HC was slowly withdrawn. 90 per cent of the symptomatic cases were controlled by HC, the remainder by TA. 65 per cent of symptomatic cases were controlled by HC; this rose to 78 per cent if patients treated by HC then TA were included...
October 1994: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/12655/takayasu-s-arteritis-clinical-study-of-107-cases
#16
E Lupi-Herrera, G Sánchez-Torres, J Marcushamer, J Mispireta, S Horwitz, J E Vela
The clinical experience derived from the retrospective study of 107 cases of TA over a 19 year period is presented. The disease predominated in females (8.5:1), with age of onset usually less than 20 years. In half of the cases an acute inflammatory phase was observed, characterized mainly by systemic and cardiovascular symptoms. Subsequently the natural course of TA was toward chronicity with gradual deterioration. The most frequent variety of TA (65 per cent of the patients) was Type III, in which the supra-aortic trunks and the abdominal aorta were involved...
January 1977: American Heart Journal
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