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https://www.readbyqxmd.com/read/28677372/early-increased-density-of-cyclooxygenase-2-cox-2-immunoreactive-neurons-in-down-syndrome
#1
Maria Mulet, José Miguel Blasco-Ibáńez, Carlos Crespo, Juan Nácher, Emilio Varea
<i>Neuroinflammation is one of the hallmarks of Alzheimer's disease. One of the enzymes involved in neuroinflammation, even in early stages of the disease, is COX-2, an inducible cyclooxygenase responsible for the generation of eicosanoids and for the generation of free radicals. Individuals with Down syndrome develop Alzheimer's disease early in life. Previous studies pointed to the possible overexpression of COX-2 and correlated it to brain regions affected by the disease. We analysed the COX-2 expression levels in individuals with Down syndrome and in young, adult and old mice of the Ts65Dn mouse model for Down syndrome...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28536672/response-to-bile-salts-in-clinical-strains-of-acinetobacter-baumannii-lacking-the-adeabc-efflux-pump-virulence-associated-with-quorum-sensing
#2
Maria López, Lucia Blasco, Eva Gato, Astrid Perez, Laura Fernández-Garcia, Luis Martínez-Martinez, Felipe Fernández-Cuenca, Jesús Rodríguez-Baño, Alvaro Pascual, German Bou, Maria Tomás
Introduction:Acinetobacter baumannii is an opportunistic nosocomial pathogen associated with multiple infections. This pathogen usually colonizes (first stage of microbial infection) host tissues that are in contact with the external environment. As one of the sites of entry in human hosts is the gastrointestinal tract, the pathogen must be capable of tolerating bile salts. However, studies analyzing the molecular characteristics involved in the response to bile salts in clinical strains of A. baumannii are scarce...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28374408/morphological-alterations-in-the-hippocampus-of-the-ts65dn-mouse-model-for-down-syndrome-correlate-with-structural-plasticity-markers
#3
Olga Villarroya, Raúl Ballestín, Rosa López-Hidalgo, Maria Mulet, José Miguel Blasco-Ibáñez, Carlos Crespo, Juan Nacher, Javier Gilabert-Juan, Emilio Varea
Down syndrome (DS) is the most common chromosomal aneuploidy. Although trisomy on chromosome 21 can display variable phenotypes, there is a common feature among all DS individuals: the presence of intellectual disability. This condition is partially attributed to abnormalities found in the hippocampus of individuals with DS and in the murine model for DS, Ts65Dn. To check if all hippocampal areas were equally affected in 4-5 month adult Ts65Dn mice, we analysed the morphology of dentate gyrus granule cells and cornu ammonis pyramidal neurons using Sholl method on Golgi-Cox impregnated neurons...
April 4, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28252471/balance-training-with-a-dynamometric-platform-following-total-knee-replacement-a-randomized-controlled-trial
#4
Sergio Roig-Casasús, José María Blasco, Laura López-Bueno, María Clara Blasco-Igual
BACKGROUND AND PURPOSE: Sensorimotor training has proven to be an efficient approach for recovering balance control following total knee replacement (TKR). The purpose of this trial was to evaluate the influence of specific balance-targeted training using a dynamometric platform on the overall state of balance in older adults undergoing TKR. METHODS: This was a randomized controlled clinical trial conducted at a university hospital rehabilitation unit. Patients meeting the inclusion criteria were randomly assigned to a control group or an experimental group...
March 1, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/27932646/genome-sequence-of-airborne-acinetobacter-sp-strain-5-2ac02-in-the-hospital-environment-close-to-the-species-of-acinetobacter-towneri
#5
Beathriz G V Barbosa, Laura Fernandez-García, Eva Gato, Maria López, Lucia Blasco, Robson Souza Leão, Rodolpho M Albano, Begoña Fernández, Felipe-Fernández Cuenca, Álvaro Pascual, German Bou, Elizabeth A Marques, María Tomás
Acinetobacter spp. are found in 53% of air colonization samples from the hospital environment. In this work, we sequenced all the genome of airborne Acinetobacter sp. strain 5-2Ac02. We found important features at the genomic level in regards to the rhizome. By phylogenetic analysis, A. towneri was the species most closely related to Acinetobacter sp. 5-2Ac02.
December 8, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27923465/lipoidic-necrobiosis
#6
Antonio Rosales-Castillo, Carmen María García-Martínez, Gonzalo Blasco-Morente, Salvador Arias-Santiago
No abstract text is available yet for this article.
August 10, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/27474211/epidemiological-investigation-of-the-first-human-brucellosis-case-in-spain-due-to-brucella-suis-biovar-1-strain-1330
#7
Cecilia Compés Dea, Joaquín Guimbao Bescós, Juan Pablo Alonso Pérez de Ágreda, Pilar María Muñoz Álvaro, José María Blasco Martínez, María Cruz Villuendas Usón
INTRODUCTION: No cases of human brucellosis caused by Brucella suis has been reported in Spain. METHODS: This study involved interviews with the case and his co-workers, inspection of their workplace, checking infection control measures, and typing the Brucella strain isolated in the blood culture. RESULTS: Brucella suis biovar 1 strain 1330 was isolated from a patient who worked in a waste treatment plant. Food borne transmission, contact with animals, and risk jobs were ruled out...
March 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/26765579/obesity-is-associated-with-gene-expression-and-imaging-markers-of-iron-accumulation-in-skeletal-muscle
#8
José María Moreno-Navarrete, Gerard Blasco, Gemma Xifra, Monika Karczewska-Kupczewska, Magdalena Stefanowicz, Natalia Matulewicz, Josep Puig, Francisco Ortega, Wifredo Ricart, Marek Straczkowski, José Manuel Fernández-Real
CONTEXT: Different genetic and imaging iron markers are known to be increased in the liver, adipose tissue, and brain of obese subjects. OBJECTIVE: We aimed to investigate these markers in human skeletal muscle. DESIGN, SETTING, PATIENTS, AND OUTCOME MEASURES: Markers of iron accumulation were measured in three different territories: Iron gene markers (TFRC1, TF, SLC11A2, FTL, FTH1, and SLC40A1) were studied in abdominal rectus abdominis (Cohort 1, n = 26) and quadriceps (Cohort 2, n = 13) muscle using real-time PCR, whereas paravertebral muscle R2* signal (as surrogate of iron content) (Cohort 3, n = 43) was evaluated by means of magnetic resonance imaging...
March 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26609732/pure-cerebellar-ataxia-linked-to-large-c9orf72-repeat-expansion
#9
Philippe Corcia, Patrick Vourc'h, Anne-Marie Guennoc, Maria Del Mar Amador, Hélène Blasco, Christian Andres, Philippe Couratier, Paul H Gordon, Vincent Meininger
No abstract text is available yet for this article.
2016: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/21818075/straight-talk-with-mar%C3%A3-a-blasco-interview-by-elie-dolgin
#10
María Blasco
No abstract text is available yet for this article.
August 2011: Nature Medicine
https://www.readbyqxmd.com/read/21602820/genome-wide-ctcf-distribution-in-vertebrates-defines-equivalent-sites-that-aid-the-identification-of-disease-associated-genes
#11
David Martin, Cristina Pantoja, Ana Fernández Miñán, Christian Valdes-Quezada, Eduardo Moltó, Fuencisla Matesanz, Ozren Bogdanović, Elisa de la Calle-Mustienes, Orlando Domínguez, Leila Taher, Mayra Furlan-Magaril, Antonio Alcina, Susana Cañón, María Fedetz, María A Blasco, Paulo S Pereira, Ivan Ovcharenko, Félix Recillas-Targa, Lluís Montoliu, Miguel Manzanares, Roderic Guigó, Manuel Serrano, Fernando Casares, José Luis Gómez-Skarmeta
Many genomic alterations associated with human diseases localize in noncoding regulatory elements located far from the promoters they regulate, making it challenging to link noncoding mutations or risk-associated variants with target genes. The range of action of a given set of enhancers is thought to be defined by insulator elements bound by the 11 zinc-finger nuclear factor CCCTC-binding protein (CTCF). Here we analyzed the genomic distribution of CTCF in various human, mouse and chicken cell types, demonstrating the existence of evolutionarily conserved CTCF-bound sites beyond mammals...
June 2011: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/21300847/mar%C3%A3-a-blasco-keeping-a-cap-on-cancer-and-aging-interview-by-caitlin-sedwick
#12
María Blasco
No abstract text is available yet for this article.
February 7, 2011: Journal of Cell Biology
https://www.readbyqxmd.com/read/20493802/telomerase-and-chromosome-end-protection-in-vivo-the-tpp1-connection
#13
COMMENT
Eric Gilson, M Teresa Teixeira
In an article published in this issue of Developmental Cell, Maria Blasco's group shows that the telomere end-binding protein TPP1 is involved in both end protection and telomerase regulation in vivo. Importantly, they highlight the relevance of telomerase activity in highly proliferative tissues and in reprogramming of cells to induced pluripotency (iPS).
May 18, 2010: Developmental Cell
https://www.readbyqxmd.com/read/19467736/-occult-renal-disease-and-drug-prescription-in-primary-care
#14
MULTICENTER STUDY
José María Peña Porta, Meliton Blasco Oliete, Carmen Vicente de Vera Floristan
OBJECTIVE: To study the prevalence of chronic kidney disease (CKD) [glomerular filtration rate (GFR) <60ml/min/1.73m(2)] and occult kidney disease (OKD) (normal serum creatinine values with GFR <60) in elderly patients. DESIGN: Retrospective, observational study. SETTING: Four primary care centres in the province of Huesca, Spain. PARTICIPANTS: About 4014 patients older than 65 years were randomly selected. MAIN MEASUREMENTS: GFR was calculated for all subjects using the four-variable modified MDRD equation...
November 2009: Atencion Primaria
https://www.readbyqxmd.com/read/18760012/neurobrucellosis-in-stranded-dolphins-costa-rica
#15
Gabriela Hernández-Mora, Rocío González-Barrientos, Juan-Alberto Morales, Esteban Chaves-Olarte, Caterina Guzmán-Verri, Elías Barquero-Calvo, Elías Baquero-Calvo, María-Jesús De-Miguel, Clara-María Marín, José-María Blasco, Edgardo Moreno
Ten striped dolphins, Stenella coeruleoalba, stranded along the Costa Rican Pacific coast, had meningoencephalitis and antibodies against Brucella spp. Brucella ceti was isolated from cerebrospinal fluid of 6 dolphins and 1 fetus. S. coeruleoalba constitutes a highly susceptible host and a potential reservoir for B. ceti transmission.
September 2008: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/18393539/feasibility-of-analyzing-fine-particulate-matter-in-air-using-solid-phase-extraction-membranes-and-dynamic-subcritical-water-extraction
#16
Johanna Tollbäck, María Blasco Bigatá, Carlo Crescenzi, Johan Ström
We have evaluated the feasibility of using Empore solid-phase extraction (SPE) membranes as an alternative to conventional techniques for sampling fine airborne particulate matter (PM), including nanoparticles, utilizing a scanning mobility particle sizer (SMPS) and a condensation particle counter to evaluate their efficiency for trapping fine particles in the 10-800 nm size range. The results demonstrate that the membranes can efficiently trap these particles and can then be conveniently packed into an extraction cell and extracted under matrix solid-phase dispersion (MSPD) conditions...
May 1, 2008: Analytical Chemistry
https://www.readbyqxmd.com/read/16800874/zinc-oxidative-stress-genetic-background-and-immunosenescence-implications-for-healthy-ageing
#17
Eugenio Mocchegiani, Marco Malavolta, Fiorella Marcellini, Graham Pawelec
The relevance of zinc for proper functioning of the entire immune system is already well documented. However, the identification of individuals who really need zinc supplementation is still debated in view of the fact that excessive zinc may also be toxic. The risk of developing zinc deficiency in people from industrialized countries is relatively low, except for elderly subjects where zinc intake may be suboptimal and inflammation is chronic. Thus, the role of zinc on the immune system and on the health of European elderly people is becoming of paramount importance, considering also that the elderly population is rapidly increasing...
2006: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/16439039/increases-of-efficacy-as-vaccine-against-brucella-abortus-infection-in-mice-by-simultaneous-inoculation-with-avirulent-smooth-bvrs-bvrr-and-rough-wbka-mutants
#18
María Jesús Grilló, Lorea Manterola, María Jesús de Miguel, Pilar María Muñoz, José María Blasco, Ignacio Moriyón, Ignacio López-Goñi
The Brucella abortus S19 and RB51 strains are the most widely used live vaccines against bovine brucellosis. However, both can induce abortion and milk excretion, S19 vaccination interferes in serological tests, and RB51 is less effective. We have shown previously that a rough wbkAB. abortus mutant is attenuated and a better vaccine than RB51 in BALB/c mice, and that mutants in the two-component regulatory system bvrS/bvrR are markedly attenuated while keeping a smooth lipopolysaccharide (S-LPS). In this work, we tested whether simultaneous inoculation with live bvrS increases wbkA vaccine efficacy in mice...
April 5, 2006: Vaccine
https://www.readbyqxmd.com/read/15085949/dr-josef-steiner-cancer-research-prize-2003-to-ejcb-board-member-mar%C3%A3-a-blasco
#19
EDITORIAL
Hans Bloemendal, Dagmar Gebauer, Reinhard Jahn, Manfred Schliwa, Sabine Werner
No abstract text is available yet for this article.
February 2004: European Journal of Cell Biology
https://www.readbyqxmd.com/read/14969562/survey-of-persistent-organochlorine-contaminants-pcbs-pcdd-fs-and-pahs-heavy-metals-cu-cd-zn-pb-and-hg-and-arsenic-in-food-samples-from-huelva-spain-levels-and-health-implications
#20
Luisa R Bordajandi, Gema Gómez, Esteban Abad, Josep Rivera, María Del Mar Fernández-Bastón, Julián Blasco, María José González
Concentrations of PCBs, PCDDs, and PCDFs, heavy metals (Cu, Cd, Zn, Pb, and Hg), and arsenic have been determined in a great variety of food samples purchased in different markets across the city of Huelva, located in southwestern Spain and under strong industrial activity. All samples analyzed presented concentrations below the maximum allowed by the European Community regarding PCDD/Fs, with the exception of samples within the meat group. An estimation of the daily intake resulted in 1.15 pg of WHO(PCDD/Fs)-TEQ/kg of body weight/day for a 70 kg person and 2...
February 25, 2004: Journal of Agricultural and Food Chemistry
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