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JOURNAL ARTICLE
Lucas Garbellotto, Elisabeth Petit, Emmanuel Brunet, Sandrine Guirronnet, Yvan Clolus, Valérie Gillet, Hubert Bourdin, Fabienne Mougin
Garbellotto, L, Petit, E, Brunet, E, Guirronnet, S, Clolus, Y, Gillet, V, Bourdin, H, and Mougin, F. Gradual advance of sleep-wake schedules before an eastward flight and phase adjustment after flight in elite cross-country mountain bikers: effects on sleep and performance. J Strength Cond Res XX(X): 000-000, 2022-Strategies, for alleviating jet lag, specifically targeted to competitive athletes have never been studied, in ecological conditions. This study aimed to assess the effects of a phase advance before a 7-hour eastward flight followed by a strategy of resynchronization at destination on sleep and physical performance in professional mountain bikers...
September 22, 2022: Journal of Strength and Conditioning Research
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JOURNAL ARTICLE
Xiang Du, Emeline Goffin, Lucie Gillard, Bénédicte Machiels, Laurent Gillet
Canine Distemper Virus (CDV) is a fatal and highly contagious pathogen of multiple carnivores. While injectable vaccines are very effective in protecting domestic animals, their use in the wild is unrealistic. Alternative vaccines are therefore needed. Adenovirus (AdV) vectors are popular vaccine vectors due to their capacity to elicit potent humoral and cellular immune responses against the antigens they carry. In parallel, vaccines based on live human AdV-4 and -7 have been used in U.S. army for several decades as replicative oral vaccines against respiratory infection with the same viruses...
August 23, 2022: Viruses
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JOURNAL ARTICLE
Maryam Isah, Salima Murtala, Sakynah Musa Abdullahi, Asmau Nasiru Hamza, Nasir Tajuddeen, Mu'ammar Lawal Dauda, Vuyisa Mzozoyana, Aliyu Muhammad Musa
Ethnobotanical information indicates that Indigofera conferta is used in northern Nigeria for the management of poisonous snakebites and the methanol extract was previously reported to have antivenin activity. In this study, we report the isolation of an oxyprenylated bioactive secondary metabolite; 2',4'- dihydroxy-4-prenyloxychalcone from the chloroform fraction of the aerial parts of the plant's methanol extract and the in vivo evaluation of the compound against Naja nigricollis venom. The compound has demonstrated significant (p < 0...
July 18, 2022: Natural Product Research
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JOURNAL ARTICLE
Benoit Pétré, Marine Paridans, Nicolas Gillain, Eddy Husson, Anne-Françoise Donneau, Nadia Dardenne, Christophe Breuer, Fabienne Michel, Margaux Dandoy, Fabrice Bureau, Laurent Gillet, Dieudonné Leclercq, Michèle Guillaume
Testing strategies are crucial to prevent and control the spread of covid-19 but suffer from a lack of investment in understanding the human factors that influence their implementation. The aim of this study was to understand the factors that encourage participation and the level of engagement of nursing homes staff in a routine saliva testing programme for COVID-19 In December 2020, nursing homes (n = 571) in Wallonia (Belgium) were invited to participate in a saliva testing programme for their staff. The directors were questioned by telephone at the end of a 3-week pilot phase...
2022: PloS One
#25
JOURNAL ARTICLE
Lize Cuypers, Jannes Bode, Kurt Beuselinck, Lies Laenen, Klaas Dewaele, Reile Janssen, Arnaud Capron, Yves Lafort, Henry Paridaens, Bertrand Bearzatto, Mathieu Cauchie, Aline Huwart, Jonathan Degosserie, Olivier Fagnart, Yarah Overmeire, Arlette Rouffiange, Ilse Vandecandelaere, Marine Deffontaine, Thomas Pilate, Nicolas Yin, Isabel Micalessi, Sandrine Roisin, Veronique Moons, Marijke Reynders, Sophia Steyaert, Coralie Henin, Elena Lazarova, Dagmar Obbels, François E Dufrasne, Hendri Pirenne, Raf Schepers, Anaëlle Collin, Bruno Verhasselt, Laurent Gillet, Stijn Jonckheere, Philippe Van Lint, Bea Van den Poel, Yolien Van der Beken, Violeta Stojkovic, Maria-Grazia Garrino, Hannah Segers, Kevin Vos, Maaike Godefroid, Valerie Pede, Friedel Nollet, Vincent Claes, Inge Verschraegen, Pierre Bogaerts, Marjan Van Gysel, Judith Leurs, Veroniek Saegeman, Oriane Soetens, Merijn Vanhee, Gilberte Schiettekatte, Evelyne Huyghe, Steven Martens, Ann Lemmens, Heleen Nailis, Kim Laffineur, Deborah Steensels, Elke Vanlaere, Jérémie Gras, Gatien Roussel, Koenraad Gijbels, Michael Boudewijns, Catherine Sion, Wim Achtergael, Wim Maurissen, Luc Iliano, Marianne Chantrenne, Geert Vanheule, Reinoud Flies, Nicolas Hougardy, Mario Berth, Vanessa Verbeke, Robin Morent, Anne Vankeerberghen, Sébastien Bontems, Kaat Kehoe, Anneleen Schallier, Giang Ho, Kristof Bafort, Marijke Raymaekers, Yolande Pypen, Amelie Heinrichs, Wim Schuermans, Dominique Cuigniez, Salah Eddine Lali, Stefanie Drieghe, Dieter Ory, Marie Le Mercier, Kristel Van Laethem, Inge Thoelen, Sarah Vandamme, Iqbal Mansoor, Carl Vael, Maxime De Sloovere, Katrien Declerck, Elisabeth Dequeker, Stefanie Desmet, Piet Maes, Katrien Lagrou, Emmanuel André
From early 2020, a high demand for SARS-CoV-2 tests was driven by several testing indications, including asymptomatic cases, resulting in the massive roll-out of PCR assays to combat the pandemic. Considering the dynamic of viral shedding during the course of infection, the demand to report cycle threshold (Ct) values rapidly emerged. As Ct values can be affected by a number of factors, we considered that harmonization of semi-quantitative PCR results across laboratories would avoid potential divergent interpretations, particularly in the absence of clinical or serological information...
June 14, 2022: Viruses
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JOURNAL ARTICLE
Salomé Desmecht, Aleksandr Tashkeev, Majdouline El Moussaoui, Nicole Marechal, Hélène Perée, Yumie Tokunaga, Celine Fombellida-Lopez, Barbara Polese, Céline Legrand, Marie Wéry, Myriam Mni, Nicolas Fouillien, Françoise Toussaint, Laurent Gillet, Fabrice Bureau, Laurence Lutteri, Marie-Pierre Hayette, Michel Moutschen, Christelle Meuris, Pieter Vermeersch, Daniel Desmecht, Souad Rahmouni, Gilles Darcis
Background: Understanding and measuring the individual level of immune protection and its persistence at both humoral and cellular levels after SARS-CoV-2 vaccination is mandatory for the management of the vaccination booster campaign. Our prospective study was designed to assess the immunogenicity of the BNT162b2 mRNA vaccine in triggering the cellular and humoral immune response in healthcare workers up to 12 months after the initial vaccination, with one additional boosting dose between 6 and 12 months...
2022: Frontiers in Immunology
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JOURNAL ARTICLE
Moritz Walter, Luke N Allen, Antonio de la Vega de León, Samuel J Webb, Valerie J Gillet
Recently, imputation techniques have been adapted to predict activity values among sparse bioactivity matrices, showing improvements in predictive performance over traditional QSAR models. These models are able to use experimental activity values for auxiliary assays when predicting the activity of a test compound on a specific assay. In this study, we tested three different multi-task imputation techniques on three classification-based toxicity datasets: two of small scale (12 assays each) and one large scale with 417 assays...
June 7, 2022: Journal of Cheminformatics
#28
JOURNAL ARTICLE
Stéphane Picot, Thomas Perpoint, Christian Chidiac, Alain Sigal, Etienne Javouhey, Yves Gillet, Laurent Jacquin, Marion Douplat, Karim Tazarourte, Laurent Argaud, Martine Wallon, Charline Miossec, Guillaume Bonnot, Anne-Lise Bienvenu
Malaria diagnosis based on microscopy is impaired by the gradual disappearance of experienced microscopists in non-endemic areas. Aside from the conventional diagnostic methods, fluorescence flow cytometry technology using Sysmex XN-31, an automated haematology analyser, has been registered to support malaria diagnosis. The aim of this prospective, monocentric, non-interventional study was to evaluate the diagnostic accuracy of the XN-31 for the initial diagnosis or follow-up of imported malaria cases compared to the reference malaria tests including microscopy, loop mediated isothermal amplification, and rapid diagnostic tests...
2022: Parasite: Journal de la Société Française de Parasitologie
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JOURNAL ARTICLE
Antonin Bal, Gregory Destras, Marina Sabatier, Maxime Pichon, Hadrien Regue, Guy Oriol, Yves Gillet, Bruno Lina, Karen Brengel-Pesce, Laurence Josset, Florence Morfin
Human Anelloviridae is a highly prevalent viral family, including three main genera- Alphatorquevirus (Torque teno virus, TTV), Betatorquevirus (Torque teno mini virus, TTMV), and Gammatorquevirus (Torque teno midi virus, TTMDV). To date, the characterization of Anelloviridae in the respiratory tract of children with acute respiratory infection (ARI) has been poorly reported and mainly focused on TTV. We performed a metagenomic analysis of eight respiratory samples collected from children with an ARI of unknown etiology (eight samples tested negative with a multiplex PCR assay, out of the 39 samples initially selected based on negative routine diagnostic testing)...
May 3, 2022: Viruses
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JOURNAL ARTICLE
Joseph Seitlinger, Anasse Nounsi, Ysia Idoux-Gillet, Eloy Santos Pujol, Hélène Lê, Erwan Grandgirard, Anne Olland, Véronique Lindner, Cécile Zaupa, Jean-Marc Balloul, Eric Quemeneur, Gilbert Massard, Pierre-Emmanuel Falcoz, Guoqiang Hua, Nadia Benkirane-Jessel
Patient-derived tumoroid (PDT) has been developed and used for anti-drug screening in the last decade. As compared to other existing drug screening models, a PDT-based in vitro 3D cell culture model could preserve the histological and mutational characteristics of their corresponding tumors and mimic the tumor microenvironment. However, few studies have been carried out to improve the microvascular network connecting the PDT and its surrounding microenvironment, knowing that poor tumor-selective drug transport and delivery is one of the major reasons for both the failure of anti-cancer drug screens and resistance in clinical treatment...
May 10, 2022: Biomedicines
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JOURNAL ARTICLE
Claude Saegerman, Anh Nguyet Diep, Véronique Renault, Anne-Françoise Donneau, Lambert Stamatakis, Wouter Coppieters, Fabienne Michel, Christophe Breuer, Margaux Dandoy, Olivier Ek, Claire Gourzones, Joey Schyns, Emeline Goffin, Frédéric Minner, Keith Durkin, Maria Artesi, Vincent Bours, Fabrice Bureau, Laurent Gillet
Background: Nursing home (NH) residents have been severely affected during the COVID-19 pandemic because of their age and underlying comorbidities. Infection and outbreaks in NHs are most likely triggered by infected workers. Screening for asymptomatic NH workers can prevent risky contact and viral transmission to the residents. This study examined the effect of the BNT162b2 mRNA COVID‑19 (Comirnaty® ; BioNTech and Pfizer) vaccination on the saliva excretion of SARS-CoV-2 among NH workers, through weekly saliva RT-qPCR testing...
2022: Commun Med (Lond)
#32
JOURNAL ARTICLE
Anthony Gagnon, Gabrielle Grenier, Christian Bocti, Virginie Gillet, Andrea A Baccarelli, Jonathan Posner, Maxime Descoteaux, Larissa Takser
Structural and functional magnetic resonance imaging (MRI) studies have suggested a neuroanatomical basis that may underly attention-deficit-hyperactivity disorder (ADHD), but the anatomical ground truth remains unknown. In addition, the role of the white matter (WM) microstructure related to attention and impulsivity in a general pediatric population is still not well understood. Using a state-of-the-art structural connectivity pipeline based on the Brainnetome atlas extracting WM connections and its subsections, we applied dimensionality reduction techniques to obtain biologically interpretable WM measures...
May 10, 2022: Cerebral Cortex
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JOURNAL ARTICLE
Brennan H Baker, Heather H Burris, Tessa R Bloomquist, Amélie Boivin, Virginie Gillet, Annie Larouche, Larissa Takser, Jean-Philippe Bellenger, Jean-Charles Pasquier, Andrea A Baccarelli
Background: The small number of studies examining the association of prenatal acetaminophen with birth outcomes have all relied on maternal self-report. It remains unknown whether prenatal acetaminophen exposure measured in a biological specimen is associated with birth outcomes. Objectives: To investigate the association of acetaminophen measured in meconium with birthweight, gestational age, preterm birth, size for gestational age, gestational diabetes, preeclampsia, and high blood pressure...
2022: Frontiers in Pediatrics
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JOURNAL ARTICLE
Robot-Mediated Inclusive Processes in Groups of Children: From Gaze Aversion to Mutual Smiling Gaze.
Sylvaine Tuncer, Sarah Gillet, Iolanda Leite
Our work is motivated by the idea that social robots can help inclusive processes in groups of children, focusing on the case of children who have newly arrived from a foreign country and their peers at school. Building on an initial study where we tested different robot behaviours and recorded children's interactions mediated by a robot in a game, we present in this paper the findings from a subsequent analysis of the same video data drawing from ethnomethodology and conversation analysis. We describe how this approach differs from predominantly quantitative video analysis in HRI; how mutual gaze appeared as a challenging interactional accomplishment between unacquainted children, and why we focused on this phenomenon...
2022: Frontiers in Robotics and AI
#35
JOURNAL ARTICLE
Tim Van Cauwenbergh, Emily Theys, Dagmar Stroeykens, Bart Croonenborghs, Annick Gillet, Aaron DeMent, Ann Van Schepdael, Erik Haghedooren
Ensuring the sterility of life science products plays a pivotal role in the healthcare sector. Gamma irradiation and ethylene oxide sterilization are two commonly applied methods for the sterilization of medical devices, packaging components and Active Pharmaceutical Ingredients (API) for medicinal products. Focussed studies on the effects of sterilization processes on APIs remain limited. In this research study, five APIs, frequently used in sterile ophthalmic preparations were subjected to both gamma irradiation and ethylene oxide under different process conditions...
January 28, 2022: Journal of Pharmaceutical Sciences
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JOURNAL ARTICLE
Anne-Françoise Donneau, Michèle Guillaume, Vincent Bours, Margaux Dandoy, Gilles Darcis, Daniel Desmecht, Anh Nguyet Diep, Laurence Fievez, Mutien-Marie Garigliany, Nicolas Gillain, Eddy Husson, Fabienne Michel, Michel Moutschen, Marine Paridans, Pétre Benoît, Catherine Sabatel, Claude Saegerman, Amandine Tytgat, Laurent Gillet, Fabrice Bureau
INTRODUCTION: For a safe and sustainable return to normal functioning of academic activities in higher education, objective-driven testing strategies that are flexible and rapidly adaptable are essential to effectively monitor and respond to new developments of the COVID-19 pandemic. To date, prospective longitudinal research on SARS-CoV-2 antibody testing in saliva and seroprevalence in higher education contexts is substantially lacking, limiting our understanding of COVID-19 prevalence, incidence and nature of the immune response to SARS-CoV-2 at various stages of the infection and vaccination...
January 25, 2022: BMJ Open
#37
JOURNAL ARTICLE
Justine Defêche, Samira Azarzar, Alyssia Mesdagh, Patricia Dellot, Amandine Tytgat, Fabrice Bureau, Laurent Gillet, Yasmine Belhadj, Sebastien Bontems, Marie-Pierre Hayette, Raphaël Schils, Souad Rahmouni, Marie Ernst, Michel Moutschen, Gilles Darcis
The testing and isolation of patients with coronavirus disease 2019 (COVID-19) are indispensable tools to control the ongoing COVID-19 pandemic. PCR tests are considered the "gold standard" of COVID-19 testing and mostly involve testing nasopharyngeal swab specimens. Our study aimed to compare the sensitivity of tests for various sample specimens. Seventy-five participants with confirmed COVID-19 were included in the study. Nasopharyngeal swabs, oropharyngeal swabs, Oracol-collected saliva, throat washes and rectal specimens were collected along with pooled swabs...
October 21, 2021: Pathogens
#38
MULTICENTER STUDY
Gabriel Lignieres, André Birgy, Camille Jung, Stéphane Bonacorsi, Corinne Levy, François Angoulvant, Emmanuel Grimprel, Marie Aliette Dommergues, Yves Gillet, Irina Craiu, Alexis Rybak, Loic De Pontual, François Dubos, Emmanuel Cixous, Vincent Gajdos, Didier Pinquier, Isabelle Andriantahina, Valérie Soussan-Banini, Emilie Georget, Elise Launay, Olivier Vignaud, Robert Cohen, Fouad Madhi
OBJECTIVES: We need studies assessing therapeutic options for oral relay in febrile urinary tract infection (FUTI) due to ESBL-producing Enterobacteriaceae (ESBL-E) in children. Amoxicillin-clavulanate/cefixime (AC-cefixime) combination seems to be a suitable option. We sought to describe the risk of recurrence at 1 month after the end of treatment for FUTI due to ESBL-E according to the oral relay therapy used. MATERIALS AND METHODS: We retrospectively identified children <18 years who were included in a previous prospective observational multicentric study on managing FUTI due to ESBL-E between 2014 and 2017 in France...
2021: PloS One
#39
JOURNAL ARTICLE
Romain Gillet, François Zhu, Pierre Padoin, Aymeric Rauch, Gabriela Hossu, Pedro Augusto Gondim Teixeira, Alain Blum
BACKGROUND: MRI diagnostic criteria of shoulder adhesive capsulitis (AC) are nowadays widely used, but there is little information available on the association between MRI findings and clinical impairment. PURPOSE: To determine the correlation of MRI findings with the Constant-Murley Score (CMS), pain duration and symptoms at the one-year follow-up in AC patients. MATERIALS AND METHODS: This monocentric prospective study included 132 patients with a clinical diagnosis of shoulder AC who underwent shoulder MRI...
August 29, 2021: Journal of Clinical Medicine
#40
JOURNAL ARTICLE
Michał O Posłuszny, Małgorzata M Waszak
OBJECTIVE: The aim of the study was to determine the influence of manipulative treatment of sacroiliac joint (SIJ) hypomobility on the ability to maintain static balance of the body. METHODS: We compared displacements of the center of pressure (COP) in 2 groups of students of the University of Physical Education: the experimental group (30 people exhibiting SIJ hypomobility) and the control group (29 people without SIJ hypomobility). A manipulation was performed in the experimental group and a placebo procedure in the control group...
August 7, 2021: Journal of Manipulative and Physiological Therapeutics
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