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https://www.readbyqxmd.com/read/29350770/the-effects-of-work-factors-on-nurses-job-satisfaction-quality-of-care-and-turnover-intentions-in-oncology
#1
Nicolas Gillet, Evelyne Fouquereau, Hélène Coillot, Baptiste Cougot, Leïla Moret, Sophie Dupont, Franck Bonnetain, Philippe Colombat
AIMS: We examined the effects of perceived supervisor support, value congruence and hospital nurse staffing on nurses' job satisfaction through the satisfaction of the three psychological needs for autonomy, competence and relatedness. Then, we examined the links between job satisfaction and quality of care as well as turnover intentions from the workplace. BACKGROUND: There is growing interest in the relationships between work factors and nurses' job satisfaction...
January 19, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29251261/diagnostic-accuracy-of-loop-mediated-isothermal-amplification-lamp-for-screening-patients-with-imported-malaria-in-a-non-endemic-setting
#2
Camille Ponce, Flora Kaczorowski, Thomas Perpoint, Patrick Miailhes, Alain Sigal, Etienne Javouhey, Yves Gillet, Laurent Jacquin, Marion Douplat, Karim Tazarourte, Véronique Potinet, Bruno Simon, Adeline Lavoignat, Guillaume Bonnot, Fatimata Sow, Anne-Lise Bienvenu, Stéphane Picot
BACKGROUND: Sensitive and easy-to-perform methods for the diagnosis of malaria are not yet available. Improving the limit of detection and following the requirements for certification are issues to be addressed in both endemic and non-endemic settings. The aim of this study was to test whether loop-mediated isothermal amplification of DNA (LAMP) may be an alternative to microscopy or real-time PCR for the screening of imported malaria cases in non-endemic area. RESULTS: 310 blood samples associated with 829 suspected cases of imported malaria were tested during a one year period...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/29246478/a-phase-iii-diagnostic-accuracy-study-of-a-rapid-diagnostic-test-for-diagnosis-of-second-stage-human-african-trypanosomiasis-in-the-democratic-republic-of-the-congo
#3
Marleen Boelaert, Deby Mukendi, Emmanuel Bottieau, Jean Roger Kalo Lilo, Kristien Verdonck, Luigi Minikulu, Barbara Barbé, Philippe Gillet, Cédric P Yansouni, François Chappuis, Pascal Lutumba
OBJECTIVES: To estimate the diagnostic accuracy of HAT Sero K-SeT for the field diagnosis of second-stage human African trypanosomiasis (HAT). DESIGN: A phase III diagnostic accuracy design. Consecutive patients with symptoms clinically suggestive of HAT were prospectively enrolled. We compared results of the index test HAT Sero K-SeT with those of a composite reference standard: demonstration of trypanosomes in cerebrospinal fluid (CSF), or trypanosomes detected in any other body fluid AND white blood cell count in CSF >5/μl...
December 6, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29175127/retro-2-and-its-dihydroquinazolinone-derivatives-inhibit-filovirus-infection
#4
Olena Shtanko, Yasuteru Sakurai, Ann N Reyes, Romain Noël, Jean-Christophe Cintrat, Daniel Gillet, Julien Barbier, Robert A Davey
Members of the family Filoviridae cause severe, often fatal disease in humans, for which there are no approved vaccines and only a few experimental drugs tested in animal models. Retro-2, a small molecule that inhibits retrograde trafficking of bacterial and plant toxins inside host cells, has been demonstrated to be effective against a range of bacterial and virus pathogens, both in vitro and in animal models. Here, we demonstrated that Retro-2 and its derivatives, Retro-2.1 and compound 25, blocked infection by Ebola virus and Marburg virus in vitro...
November 21, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29031699/a-genetic-tool-to-quantify-trans-translation-activity-in-vivo
#5
Kevin Macé, Fanny Demay, Charlotte Guyomar, Sylvie Georgeault, Emmanuel Giudice, Renan Goude, Annie Trautwetter, Gwennola Ermel, Carlos Blanco, Reynald Gillet
In bacteria, trans-translation is the main quality control mechanism for rescuing ribosomes arrested during translation. This key process is universally conserved and plays a critical role in the viability and virulence of many pathogens. We developed a reliable in vivo double-fluorescence reporter system for the simultaneous quantification of both trans-translation and the associated proteolysis activities in bacteria. The assay was validated using mutant bacteria lacking tmRNA, SmpB, and the ClpP protease...
October 13, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28952852/effects-of-self-myofascial-release-on-shoulder-function-and-perception-in-adolescent-tennis-players
#6
Julien Le Gal, Mickael Begon, Benoit Gillet, Isabelle Rogowski
CONTEXT: Tennis induces a decreased internal rotation range of motion at the dominant glenohumeral joint. The effects of self-myofascial release have not yet been investigated to restore glenohumeral range of motion. OBJECTIVE: This study aimed at investigating the effects of self-myofascial release on the shoulder function and perception in adolescent tennis players. DESIGN: Test-retest design. SETTING: Tennis training sport facilities...
September 27, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28853317/shoe-drop-reduction-influences-the-lower-limb-biomechanics-of-children-tennis-players-during-an-open-stance-forehand-a-longitudinal-study
#7
Alexis Herbaut, Emilie Simoneau-Buessinger, Franck Barbier, Christophe Gillet, Maxime Roux, Nils GuéGuen, Pascale Chavet
Compared to traditional tennis shoes, using 0-drop shoes was shown to induce an immediate switch from rear- to forefoot strike pattern to perform an open stance tennis forehand for 30% of children tennis players. The purpose of the study was to examine the long-term effects of a gradual reduction in the shoe drop on the biomechanics of children tennis players performing open stance forehands. Thirty children tennis players participated in 2 laboratory biomechanical test sessions (intermediate: +4 months and final: +8 months) after an inclusion visit where they were randomly assigned to control (CON) or experimental (EXP) group...
August 30, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28839497/bronchodilator-response-assessment-of-the-small-airways-obstructive-pattern
#8
Plamen Bokov, Clémence Martin, Sémia Graba, Karine Gillet-Juvin, Mohamed Essalhi, Christophe Delclaux
BACKGROUND: A concomitant decrease in FEV1 and FVC with normal FEV1/FVC ratio and TLC defines small airways obstructive pattern (SAOP) and constitutes a classic pitfall of pulmonary-function-tests interpretation. OBJECTIVE: To evaluate the prevalence of flow- (FEV1 increase≥12% and 200 mL), volume- (FVC or inspiratory capacity [IC] increase≥12% and 200 mL), flow and volume-, and non-response to bronchodilation in patients with SAOP. An additional objective was to assess whether impulse oscillometry (IOS) parameters allow the diagnosis of SAOP and its reversibility...
2017: Open Respiratory Medicine Journal
https://www.readbyqxmd.com/read/28820708/clinical-spectrum-etiology-and-outcome-of-neurological-disorders-in-the-rural-hospital-of-mosango-the-democratic-republic-of-congo
#9
Deby Mukendi, Jean-Roger Lilo Kalo, Alain Mpanya, Luigi Minikulu, Tharcisse Kayembe, Pascal Lutumba, Barbara Barbé, Philippe Gillet, Jan Jacobs, Harry Van Loen, Cédric P Yansouni, François Chappuis, Raffaella Ravinetto, Kristien Verdonck, Marleen Boelaert, Andrea S Winkler, Emmanuel Bottieau
There is little published information on the epidemiology of neurological disorders in rural Central Africa, although the burden is considered to be substantial. This study aimed to investigate the pattern, etiology, and outcome of neurological disorders in children > 5 years and adults admitted to the rural hospital of Mosango, province of Kwilu, Democratic Republic of Congo, with a focus on severe and treatable infections of the central nervous system (CNS). From September 2012 to January 2015, 351 consecutive patients hospitalized for recent and/or ongoing neurological disorder were prospectively evaluated by a neurologist, subjected to a set of reference diagnostic tests in blood or cerebrospinal fluid, and followed-up for 3-6 months after discharge...
November 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28794046/proteomic-and-functional-analyses-of-the-virion-transmembrane-proteome-of-cyprinid-herpesvirus-3
#10
Catherine Vancsok, M Michelle D Peñaranda, V Stalin Raj, Baptiste Leroy, Joanna Jazowiecka-Rakus, Maxime Boutier, Yuan Gao, Gavin S Wilkie, Nicolás M Suárez, Ruddy Wattiez, Laurent Gillet, Andrew J Davison, Alain F C Vanderplasschen
Virion transmembrane proteins (VTPs) mediate key functions in the herpesvirus infectious cycle. Cyprinid herpesvirus 3 (CyHV-3) is the archetype of fish alloherpesviruses. The present study was devoted to CyHV-3 VTPs. Using mass spectrometry approaches, we identified 16 VTPs of the CyHV-3 FL strain. Mutagenesis experiments demonstrated that eight of these proteins are essential for viral growth in vitro (open reading frame 32 [ORF32], ORF59, ORF81, ORF83, ORF99, ORF106, ORF115, and ORF131), and eight are nonessential (ORF25, ORF64, ORF65, ORF108, ORF132, ORF136, ORF148, and ORF149)...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28628945/precise-spike-timing-dynamics-of-hippocampal-place-cell-activity-sensitive-to-cholinergic-disruption
#11
Ehren L Newman, Sarah Jo C Venditto, Jason R Climer, Elijah A Petter, Shea N Gillet, Sam Levy
New memory formation depends on both the hippocampus and modulatory effects of acetylcholine. The mechanism by which acetylcholine levels in the hippocampus enable new encoding remains poorly understood. Here, we tested the hypothesis that cholinergic modulation supports memory formation by leading to structured spike timing in the hippocampus. Specifically, we tested if phase precession in dorsal CA1 was reduced under the influence of a systemic cholinergic antagonist. Unit and field potential were recorded from the dorsal CA1 of rats as they completed laps on a circular track for food rewards before and during the influence of the systemically administered acetylcholine muscarinic receptor antagonist scopolamine...
October 2017: Hippocampus
https://www.readbyqxmd.com/read/28575315/managing-varicella-zoster-virus-contact-and-infection-in-patients-on-anti-rheumatic-therapy
#12
Matthew Cates, Matthew Donati, Sophie Gillet, Andrew Ustianowski, James Galloway
Chickenpox and shingles can be more severe and occasionally life threatening in immunosuppressed patients. As such, some groups warrant a more detailed history, serological testing and consideration of prophylaxis following contact with the virus. Active disease may also require more aggressive treatment with antivirals. Guidance for the use of varicella zoster immunoglobulin has recently been updated by Public Health England with important implications for rheumatology patients.
May 29, 2017: Rheumatology
https://www.readbyqxmd.com/read/28532864/association-between-composites-of-selected-motion-palpation-and-pain-provocation-tests-for-sacroiliac-joint-disorders
#13
Manijeh Soleimanifar, Noureddin Karimi, Amir Massoud Arab
BACKGROUND: The sacroiliac joint (SIJ) has been implicated as a potential source of low back and buttock pain. Several types of motion palpation and pain provocation tests are used to evaluate SIJ dysfunction. OBJECTIVE: The purpose of this study was to investigate the relationship between motion palpation and pain provocation tests in assessment of SIJ problems. DESIGN: This study is Descriptive Correlation. METHODS: 50 patients between the ages of 20 and 65 participated...
April 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28209389/physical-stability-of-highly-concentrated-injectable-drugs-solutions-used-in-intensive-care-units
#14
M Closset, J D Hecq, L Soumoy, J Simar, E Gonzalez, L Charlet, C Declave, P Gillet, L Galanti
BACKGROUND: The intensive care department of the institution use drug solutions within higher concentration to avoid fluid overload. The purpose of the study is to prove the physical stability of different injectable drugs within high concentration (amiodarone 25mg/mL, isosorbide 0.60mg/mL, lorazepam 0.16mg/mL, noradrenalin 0.120 and 0.240mg/mL, salbutamol 0.06mg/mL and sodium valproate 12mg/mL) to ensure the patients safety. METHODS: Five of 30 or 50mL polypropylene syringes were prepared for each solution under aseptic conditions and stored at room temperature...
May 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/28161232/-correctly-address-the-cause-of-hemophagocytic-lymphohistiocytosis
#15
M Penel-Page, B Ben Said, A Phan, L Hees, C Hartmann-Merlin, S Girard, Y Gillet, A Belot
Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe syndrome usually associated with a cytotoxicity deficiency, which leads to an excess of immune response driven by activated macrophages and cytotoxic T cells. In children, HLH can be genetic, as part of a familial lymphohistiocytosis, or secondary: the most frequent causes are systemic-onset juvenile idiopathic arthritis, hematological malignancies, and severe infections, especially with Ebstein-Barr virus or leishmaniosis. We report on the case of a 3-year-old girl with no past medical history, who presented inaugural Pseudomonas aeruginosa maxillary osteitis, with secondary HLH...
March 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28159322/biocompatibility-of-polymer-infiltrated-ceramic-network-picn-materials-with-human-gingival-keratinocytes-hgks
#16
Charlotte Grenade, Marie-Claire De Pauw-Gillet, Catherine Pirard, Virginie Bertrand, Corinne Charlier, Alain Vanheusden, Amélie Mainjot
OBJECTIVE: Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials, a new class of CAD-CAM composites, is poorly explored in the literature, in particular, no data are available regarding Human Gingival Keratinocytes (HGK). The first objective of this study was to evaluate the in vitro biocompatibility of PICNs with HGKs in comparison with other materials typically used for implant prostheses. The second objective was to correlate results with PICN monomer release and indirect cytotoxicity...
January 31, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27993515/cardiometabolic-risk-is-associated-with-the-severity-of-sleep-disordered-breathing-in-children-with-obesity
#17
Laurie Isacco, Johanna Roche, Sylvain Quinart, David Thivel, Valérie Gillet, Véronique Nègre, Fabienne Mougin
BACKGROUND: The alarming progression of pediatric obesity is associated with the development of sleep-disordered breathing (SDB), and both exhibit similar adverse cardiometabolic health outcomes. Physical activity level (PAL) may counteract sleep and metabolic disturbances. The present study investigates i) the association between the metabolic syndrome in childhood obesity and SDB, ii) the impact of SDB severity on cardiometabolic risk scores and PAL in children with obesity. METHODS: Maturation status (Tanner stages), anthropometric (height, weight, body mass index, waist circumference, body adiposity index) and cardiometabolic characteristics (systolic and diastolic blood pressure, lipid and glycemic profiles) were assessed in 83 obese children (mean±SD, age: 10...
March 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/27812090/diagnosis-of-persistent-fever-in-the-tropics-set-of-standard-operating-procedures-used-in-the-nidiag-febrile-syndrome-study
#18
Emilie Alirol, Ninon Seiko Horie, Barbara Barbé, Veerle Lejon, Kristien Verdonck, Philippe Gillet, Jan Jacobs, Philippe Büscher, Basudha Kanal, Narayan Raj Bhattarai, Sayda El Safi, Thong Phe, Kruy Lim, Long Leng, Pascal Lutumba, Deby Mukendi, Emmanuel Bottieau, Marleen Boelaert, Suman Rijal, François Chappuis
In resource-limited settings, the scarcity of skilled personnel and adequate laboratory facilities makes the differential diagnosis of fevers complex [1-5]. Febrile illnesses are diagnosed clinically in most rural centers, and both Rapid Diagnostic Tests (RDTs) and clinical algorithms can be valuable aids to health workers and facilitate therapeutic decisions [6,7]. The persistent fever syndrome targeted by NIDIAG is defined as presence of fever for at least one week. The NIDIAG clinical research consortium focused on potentially severe and treatable infections and therefore targeted the following conditions as differential diagnosis of persistent fever: visceral leishmaniasis (VL), human African trypanosomiasis (HAT), enteric (typhoid and paratyphoid) fever, brucellosis, melioidosis, leptospirosis, malaria, tuberculosis, amoebic liver abscess, relapsing fever, HIV/AIDS, rickettsiosis, and other infectious diseases (e...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27717815/reorganization-of-motor-cortex-and-impairment-of-motor-performance-induced-by-hindlimb-unloading-are-partially-reversed-by-cortical-igf-1-administration
#19
Julien Mysoet, Marie-Hélène Canu, Christophe Gillet, Julie Fourneau, Cyril Garnier, Bruno Bastide, Erwan Dupont
Immobilization, bed rest, or sedentary lifestyle, are known to induce a profound impairment in sensorimotor performance. These alterations are due to a combination of peripheral and central factors. Previous data conducted on a rat model of disuse (hindlimb unloading, HU) have shown a profound reorganization of motor cortex and an impairment of motor performance. Recently, our interest was turned towards the role of insulin-like growth factor 1 (IGF-1) in cerebral plasticity since this growth factor is considered as the mediator of beneficial effects of exercise on the central nervous system, and its cortical level is decreased after a 14-day period of HU...
October 4, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27701404/a-multicenter-study-benchmarks-software-tools-for-label-free-proteome-quantification
#20
MULTICENTER STUDY
Pedro Navarro, Jörg Kuharev, Ludovic C Gillet, Oliver M Bernhardt, Brendan MacLean, Hannes L Röst, Stephen A Tate, Chih-Chiang Tsou, Lukas Reiter, Ute Distler, George Rosenberger, Yasset Perez-Riverol, Alexey I Nesvizhskii, Ruedi Aebersold, Stefan Tenzer
Consistent and accurate quantification of proteins by mass spectrometry (MS)-based proteomics depends on the performance of instruments, acquisition methods and data analysis software. In collaboration with the software developers, we evaluated OpenSWATH, SWATH 2.0, Skyline, Spectronaut and DIA-Umpire, five of the most widely used software methods for processing data from sequential window acquisition of all theoretical fragment-ion spectra (SWATH)-MS, which uses data-independent acquisition (DIA) for label-free protein quantification...
November 2016: Nature Biotechnology
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