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https://www.readbyqxmd.com/read/29424467/facilitation-of-ca2-induced-opening-of-the-mitochondrial-permeability-transition-pore-either-by-nicotinamide-nucleotide-transhydrogenase-deficiency-or-statins-treatment
#1
REVIEW
Estela N B Busanello, Tiago R Figueira, Ana C Marques, Claudia D C Navarro, Helena C F Oliveira, Anibal E Vercesi
Mitochondrial redox imbalance and high Ca2+ uptake induce the opening of the permeability transition pore (PTP) that leads to disruption of energy-linked mitochondrial functions and triggers cell death in many disease states. In this review, we discuss the major results from our studies investigating the consequences of NAD(P)-transhydrogenase (NNT) deficiency, and of statins treatment for mitochondrial functions and susceptibility to Ca2+ -induced PTP. We highlight the aggravation of high fat diet-induced fatty liver disease in the context of NNT deficiency and the role of antioxidants in the prevention of statins toxicity to mitochondria...
February 9, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29423546/association-between-incision-technique-for-hamstring-tendon-harvest-in-anterior-cruciate-ligament-reconstruction-and-the-risk-of-injury-to-the-infra-patellar-branch-of-the-saphenous-nerve-a-meta-analysis
#2
REVIEW
Alberto Grassi, Francesco Perdisa, Kristian Samuelsson, Eleonor Svantesson, Matteo Romagnoli, Federico Raggi, Teide Gaziano, Massimiliano Mosca, Olufemi Ayeni, Stefano Zaffagnini
PURPOSE: To determine how the incision technique for hamstring tendon (HT) harvest in anterior cruciate ligament (ACL) reconstruction affects the risk of injury to the IPBSN and clinical outcome. METHODS: A systematic literature search of the MEDLINE/Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL) and EBSCOhost electronic databases and clinicaltrials.gov for unpublished studies was performed to identify comparative studies investigating injury to the IPBSN after HT ACL reconstruction by comparing at least two different incision techniques...
February 8, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29422409/computer-therapy-for-the-anxiety-and-depression-disorders-is-effective-acceptable-and-practical-health-care-an-updated-meta-analysis
#3
REVIEW
G Andrews, A Basu, P Cuijpers, M G Craske, P McEvoy, C L English, J M Newby
BACKGROUND: A 2010 meta-analysis of internet-delivered CBT (iCBT) RCTs argued 'computer therapy for the anxiety and depressive disorders was effective, acceptable and practical health care' without data on effectiveness or practicality in routine practice. METHODS: Databases, reviews and meta-analyses were searched for randomised controlled trials of cCBT or iCBT versus a control group (care as usual, waitlist, information control, psychological placebo, pill placebo, etc...
February 1, 2018: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29408906/efficacy-and-safety-of-modified-tongxie-yaofang-in-diarrhea-predominant-irritable-bowel-syndrome-management-a-meta-analysis-of-randomized-positive-medicine-controlled-trials
#4
Yun-Kai Dai, Dan-Yan Li, Yun-Zhan Zhang, Meng-Xin Huang, Yi-le Zhou, Jin-Tong Ye, Qi Wang, Ling Hu
OBJECTIVE: To systematically evaluate the efficacy and safety of Modified Tongxie Yaofang (M-TXYF) for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D). METHOD: Electronic databases including PubMed, Springer Link, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature (CBM), Wanfang, and Chinese Scientific Journals Database (VIP) were conducted from their inception through May 11, 2017 without language restrictions...
2018: PloS One
https://www.readbyqxmd.com/read/29405923/effectiveness-of-web-and-mobile-based-treatment-of-subthreshold-depression-with-adherence-focused-guidance-a-single-blind-randomized-controlled-trial
#5
David Daniel Ebert, Claudia Buntrock, Dirk Lehr, Filip Smit, Heleen Riper, Harald Baumeister, Pim Cuijpers, Matthias Berking
Evidence for the impact of psychological Interventions for subthreshold depression (sD) is conflicting. Moreover, human resources to deliver such treatments are limited. This study aimed to evaluate the effectiveness of a web-based intervention with adherence-focused guidance in the treatment of sD. Participants with sD (CES-D≥ 16, no Major Depressive Disorder according to DSM-IV criteria, N = 204) recruited via a large health insurance were randomly allocated to a web-based mobile-supported cognitive-behavioral intervention or to a waitlist control condition with unrestricted access to usual care...
January 2018: Behavior Therapy
https://www.readbyqxmd.com/read/29405612/risk-scoring-tool-to-predict-respiratory-syncytial-virus-hospitalisation-in-premature-infants
#6
Maarten O Blanken, Bosco Paes, Evan J Anderson, Marcello Lanari, Margaret Sheridan-Pereira, Scot Buchan, John R Fullarton, ElizaBeth Grubb, Gerard Notario, Barry S Rodgers-Gray, Xavier Carbonell-Estrany
BACKGROUND: The objective was to develop a risk scoring tool which predicts respiratory syncytial virus hospitalisation (RSVH) in moderate-late preterm infants (32-35 weeks' gestational age) in the Northern Hemisphere. METHODS: Risk factors for RSVH were pooled from six observational studies of infants born 32 weeks and 0 days to 35 weeks and 6 days without comorbidity from 2000 to 2014. Of 13 475 infants, 484 had RSVH in the first year of life. Logistic regression was used to identify the most predictive risk factors, based on area under the receiver operating characteristic curve (AUROC)...
February 6, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29388063/medical-cannabis-for-neuropathic-pain
#7
REVIEW
Gemayel Lee, Brittany Grovey, Tim Furnish, Mark Wallace
PURPOSE OF REVIEW: Many cultures throughout history have used cannabis to treat a variety of painful ailments. Neuropathic pain is a complicated condition that is challenging to treat with our current medications. Recent scientific discovery has elucidated the intricate role of the endocannabinoid system in the pathophysiology of neuropathic pain. As societal perceptions change, and legislation on medical cannabis relaxes, there is growing interest in the use of medical cannabis for neuropathic pain...
February 1, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29385792/efficacy-of-micronized-purified-flavonoid-fraction-daflon%C3%A2-on-improving-individual-symptoms-signs-and-quality-of-life-in-patients-with-chronic-venous-disease-a-systematic-review-and-meta-analysis-of-randomized-double-blind-placebo-controlled-trials
#8
Stavros Kakkos, Andrew Nicolaides
INTRODUCTION: The use of a venoactive drug is considered an important component of medical treatment of chronic venous disease (CVD), although the efficacy of certain VADs on one or more individual leg symptoms or signs may have not been extensively studied to justify a strong recommendation in guidelines on CVD. The aim of this systematic review and metaanalysis was to study the effectiveness of the micronized purified flavonoid fraction (MPFF, Daflon®) across the spectrum of defined venous symptoms, signs, quality of life (QoL) and treatment assessment by the physician...
January 31, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29384410/strategies-for-improving-dabigatran-adherence-for-stroke-prevention-in-patients-with-non-valvular-atrial-fibrillation-education-and-drug-intake-reminders-facilita-study
#9
Emilio Márquez-Contreras, Nieves Martell-Claros, Sara Márquez-Rivero, Enrique Hermida-Campa, Carmen Gracia-Diez, Eugenio Sanchez-López, Vicente Gil-Guillén
OBJECTIVE: To assess the efficacy of a mixed intervention, educational and reminder calendar of the intake, as a strategy to improve therapeutic adherence with dabigatran in patients with non-valvular atrial fibrillation (NVAF). METHODS: Prospective, longitudinal, multicenter study, carried out in 110 specialized healthcare centers in Spain. 726 patients treated with dabigatran prescribed for stroke prevention were included. A cluster randomization was performed based on two groups: 1) Control Group (CG) as usual clinical practice and Intervention Group (IG) with a mixed strategy: a) Healthcare education and b) Use of a reminder calendar for taking the anticoagulant medication...
January 31, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29376560/inotropic-agents-and-vasodilator-strategies-for-the-treatment-of-cardiogenic-shock-or-low-cardiac-output-syndrome
#10
REVIEW
Julia Schumann, Eva C Henrich, Hellen Strobl, Roland Prondzinsky, Sophie Weiche, Holger Thiele, Karl Werdan, Stefan Frantz, Susanne Unverzagt
BACKGROUND: Cardiogenic shock (CS) and low cardiac output syndrome (LCOS) as complications of acute myocardial infarction (AMI), heart failure (HF) or cardiac surgery are life-threatening conditions. While there is a broad body of evidence for the treatment of people with acute coronary syndrome under stable haemodynamic conditions, the treatment strategies for people who become haemodynamically unstable or develop CS remain less clear. We have therefore summarised here the evidence on the treatment of people with CS or LCOS with different inotropic agents and vasodilative drugs...
January 29, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29362828/genetic-differences-in-c57bl-6-mouse-substrains-affect-kidney-crystal-deposition
#11
Masayuki Usami, Atsushi Okada, Kazumi Taguchi, Shuzo Hamamoto, Kenjiro Kohri, Takahiro Yasui
We previously established an experimental model of calcium oxalate crystal deposition in the mouse kidney using C57BL/6 mice. C57BL/6J (B6J) and C57BL/6N (B6N) are two core substrains of C57BL/6 mice. B6J and B6N substrains have approximately the same genomic sequence. However, in whole-genome analyses, substrains have slight genetic differences in some genes. In this study, we used these substrains as kidney crystal formation models and compared their genetic backgrounds to elucidate the pathogenic mechanisms of kidney stone formation...
January 23, 2018: Urolithiasis
https://www.readbyqxmd.com/read/29362444/treatment-of-bipolar-depression-with-minocycline-and-or-aspirin-an-adaptive-2%C3%A3-2-double-blind-randomized-placebo-controlled-phase-iia-clinical-trial
#12
Jonathan B Savitz, T Kent Teague, Masaya Misaki, Matt Macaluso, Brent E Wurfel, Matt Meyer, Douglas Drevets, William Yates, Ondria Gleason, Wayne C Drevets, Sheldon H Preskorn
Given evidence of chronic inflammation in bipolar disorder (BD), we tested the efficacy of aspirin and minocycline as augmentation therapy for bipolar depression. Ninety-nine depressed outpatients with BD were enrolled in a 6 week, double-blind, placebo-controlled trial, and randomized to one of four groups: active minocycline (100 mg b.i.d.) + active aspirin (81 mg b.i.d.) (M + A); active minocycline + placebo aspirin (M + P); placebo-minocycline + active aspirin (A + P); and placebo-minocycline + placebo aspirin (P + P)...
January 24, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29361995/the-effects-of-psychotherapy-for-depression-on-anxiety-symptoms-a-meta-analysis
#13
Erica Weitz, Annet Kleiboer, Annemieke van Straten, Pim Cuijpers
BACKGROUND: More than half of patients who present with depressive disorders also have elevated comorbid anxiety symptoms. Given the high comorbidity between these disorders, it is important to understand the extent that psychotherapies for depression additionally ameliorate symptoms of anxiety. METHODS: Systematic searches were conducted in PubMed, PSYCinfo, EMBASE, and the Cochrane Registry of Controlled Trials. Included studies were randomized controlled trials that compared psychotherapy compared with a control condition for the treatment of adults with a primary diagnosis or elevated symptoms of depression and that examined the effects of treatment on anxiety outcomes...
January 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29360406/effect-of-hip-focused-injury-prevention-training-for-anterior-cruciate-ligament-injury-reduction-in-female-basketball-players-a-12-year-prospective-intervention-study
#14
Yorikatsu Omi, Dai Sugimoto, Setsurou Kuriyama, Tomohisa Kurihara, Kenji Miyamoto, Songjo Yun, Tatsuhiro Kawashima, Norikazu Hirose
BACKGROUND: Programs to prevent anterior cruciate ligament (ACL) injuries in female basketball players are scarce. Also, ACL injury prevention training that focuses on hip joint function has not been reported. PURPOSE: To determine the effectiveness of a hip-focused ACL injury prevention program in female basketball players. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: A prospective intervention study was conducted for 12 years...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29325728/myo-inositol-lowers-the-risk-of-developing-gestational-diabetic-mellitus-in-pregnancies-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-with-trial-sequential-analysis
#15
REVIEW
Xianshan Guo, Shizhe Guo, Zhiyi Miao, Zhen Li, Hongya Zhang
AIMS: to explore the potential benefit of myo-inositol on pregnant women with high risk of developing gestational diabetes mellitus (GDM). METHODS: Pubmed, Embase, and Cochrane library were systematically searched for randomized controlled trials (RCTs) comparing myo-inositol with placebo for pregnant women with risk factors of GDM. Primary outcome were the incidence of GDM and birth weight. Secondary outcomes included fasting, 1h, and 2h oral glucose tolerance test (OGTT), and complications...
July 21, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29318526/evaluation-of-the-protection-provided-by-hepatitis-b-vaccination-in-india
#16
Jacob Puliyel, Pathik Naik, Ashish Puliyel, Kishore Agarwal, Vandana Lal, Nimmi Kansal, Devki Nandan, Vikas Tripathi, Prashant Tyagi, Saroj K Singh, Rajeev Srivastava, Utkarsh Sharma, V Sreenivas
OBJECTIVE: In India, Hepatitis B vaccination is recommended at 6 wk except for hospital-deliveries. The authors examined protection afforded by the birth dose. METHODS: A case-control study was done. HBsAg and HBcAb were tested in 2671 children, 1 to 5 y and HBsAb was evaluated in a subset of 1413 children. Vaccination history was recorded. Cases were HBsAg carriers. In another analysis, children who got infected (HBsAg and/or HBcAb positive) were considered as cases...
January 10, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29314659/effectiveness-of-using-a-new-polyurethane-foam-multi-layer-dressing-in-the-sacral-area-to-prevent-the-onset-of-pressure-ulcer-in-the-elderly-with-hip-fractures-a-pragmatic-randomised-controlled-trial
#17
Cristiana Forni, Fabio D'Alessandro, Pina Gallerani, Rossana Genco, Andrea Bolzon, Caterina Bombino, Sandra Mini, Laura Rocchegiani, Teresa Notarnicola, Arianna Vitulli, Alfredo Amodeo, Guglielmo Celli, Patrizia Taddia
Hip fractures in the elderly are a serious problem for the health service due to the high rate of complications. One of these complications is pressure ulcers that, according to the literature, occur in 8.8% to 55% of patients and mainly arise in the sacral area. The present randomised controlled trial tests whether applying a new innovative multi-layer polyurethane foam dressing (ALLEVYN LIFE™), reduces the onset of pressure ulcers in the sacral area. From March to December 2016, 359 fragility hip fracture patients were randomly divided into 2 groups: 182 in the control group and 177 in the experimental group...
January 4, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29286930/hypoxic-ischemic-brain-injury-planned-delivery-before-intrapartum-events
#18
David Odd, Axel Heep, Karen Luyt, Tim Draycott
BACKGROUND: Mothers are increasingly given greater control over many of the choices around birth, although there is little robust evidence to inform these choices. After an infant is born with HIE the question of whether it was predictable, or preventable, is often raised. Intrapartum 'sentinel' events and antenatal predictors of HIE have been well described, however there is little evidence how antenatal and intrapartum factors interact. This is particularly important when elective delivery by lower segment caesarean section (LSCS) has been shown to be beneficial in high risk groups...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29285488/comparative-effectiveness-and-safety-of-empagliflozin-on-cardiovascular-mortality-and-morbidity-in-adults-with-type-2-diabetes
#19
Wilbert S Aronow, Tatyana A Shamliyan
Background: Based on a single placebo-controlled randomized clinical trial, empagliflozin is licensed to reduce cardiovascular death in diabetes and comorbid cardiovascular disease. Methods: We examined the comparative effectiveness of empagliflozin on mortality and cardiovascular morbidity in type 2 diabetes. We conducted random-effects direct frequentist meta-analyses of aggregate data and appraised the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29280475/the-comparative-efficacy-and-safety-of-sugammadex-and-neostigmine-in-reversing-neuromuscular-blockade-in-adults-a-cochrane-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#20
REVIEW
A-M Hristovska, P Duch, M Allingstrup, A Afshari
We compared the efficacy and safety of sugammadex and neostigmine in reversing neuromuscular blockade in adults. Our outcomes were: recovery time from second twitch to train-of-four ratio > 0.9; recovery time from post-tetanic count 1-5 to train-of-four ratio > 0.9; and risk of composite adverse and serious adverse events. We searched for randomised clinical trials irrespective of publication status and date, blinding status, outcomes reported or language. We included 41 studies with 4206 participants...
December 27, 2017: Anaesthesia
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