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https://www.readbyqxmd.com/read/29040268/benefit-and-harm-of-intensive-blood-pressure-treatment-derivation-and-validation-of-risk-models-using-data-from-the-sprint-and-accord-trials
#1
Sanjay Basu, Jeremy B Sussman, Joseph Rigdon, Lauren Steimle, Brian T Denton, Rodney A Hayward
BACKGROUND: Intensive blood pressure (BP) treatment can avert cardiovascular disease (CVD) events but can cause some serious adverse events. We sought to develop and validate risk models for predicting absolute risk difference (increased risk or decreased risk) for CVD events and serious adverse events from intensive BP therapy. A secondary aim was to test if the statistical method of elastic net regularization would improve the estimation of risk models for predicting absolute risk difference, as compared to a traditional backwards variable selection approach...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29036176/association-and-clinical-utility-of-nat2-in-the-prediction-of-isoniazid-induced-liver-injury-in-singaporean-patients
#2
Sze Ling Chan, Angeline Poh Gek Chua, Folefac Aminkeng, Cynthia Bin Eng Chee, Shengnan Jin, Marie Loh, Suay Hong Gan, Yee Tang Wang, Liam R Brunham
BACKGROUND AND AIMS: Isoniazid (INH) is part of the first-line-therapy for tuberculosis (TB) but can cause drug-induced liver injury (DILI). Several candidate single nucleotide polymorphisms (SNPs) have been previously identified but the clinical utility of these SNPs in the prediction of INH-DILI remains uncertain. The aim of this study was to assess the association between selected candidate SNPs and the risk of INH-DILI and to assess the clinical validity of associated variants in a Singaporean population...
2017: PloS One
https://www.readbyqxmd.com/read/29024264/deutetrabenazine-for-tardive-dyskinesia-a-systematic-review-of-the-efficacy-and-safety-profile-for-this-newly-approved-novel-medication-what-is-the-number-needed-to-treat-number-needed-to-harm-and-likelihood-to-be-helped-or-harmed
#3
REVIEW
Leslie Citrome
OBJECTIVE: Deutetrabenazine is a deuterated formulation of tetrabenazine. The aim of this systematic review is to describe the efficacy, tolerability and safety of deutetrabenazine for the treatment of tardive dyskinesia (TD). DATA SOURCES: The pivotal registration trials were accessed by querying http://www.ncbi.nlm.nih.gov/pubmed/ and http://www.clinicaltrials.gov, for the search terms 'deutetrabenazine' OR 'SD-809', and by also querying the EMBASE (Elsevier) commercial database for clinical poster abstracts, and by asking the manufacturer for copies of posters presented at congresses...
October 12, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28987949/zingiberis-rhizoma-mediated-enhancement-of-the-pharmacological-effect-of-aconiti-lateralis-radix-praeparata-against-acute-heart-failure-and-the-underlying-biological-mechanisms
#4
Lu Zhang, Xiaohua Lu, Jiabo Wang, Pengyan Li, Haotian Li, Shizhang Wei, Xuelin Zhou, Kun Li, Lifu Wang, Ruilin Wang, Yanling Zhao, Xiaohe Xiao
Aconiti Lateralis Radix Praeparata (Fuzi), a type of Chinese materia medica, has been used to treat acute and chronic heart failure (HF) in traditional Chinese medicine and has been proven in numerous animal studies. It is also well-known that Zingiberis Rhizoma (Ganjiang) is ineffective in the treatment of HF, but it can enhance the anti-HF effect of Fuzi. However, the mechanism underlying this compatibility is still not well investigated. To investigate this mechanism, a model of acute heart failure (AHF) in SD rats induced by propafenone hydrochloride was established in this study...
October 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28976987/assessing-the-neuroprotective-benefits-for-babies-of-antenatal-magnesium-sulphate-an-individual-participant-data-meta-analysis
#5
Caroline A Crowther, Philippa F Middleton, Merryn Voysey, Lisa Askie, Lelia Duley, Peter G Pryde, Stéphane Marret, Lex W Doyle
BACKGROUND: Babies born preterm are at an increased risk of dying in the first weeks of life, and those who survive have a higher rate of cerebral palsy (CP) compared with babies born at term. The aim of this individual participant data (IPD) meta-analysis (MA) was to assess the effects of antenatal magnesium sulphate, compared with no magnesium treatment, given to women at risk of preterm birth on important maternal and fetal outcomes, including survival free of CP, and whether effects differed by participant or treatment characteristics such as the reason the woman was at risk of preterm birth, why treatment was given, the gestational age at which magnesium sulphate treatment was received, or the dose and timing of the administration of magnesium sulphate...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28972004/prevention-of-stroke-with-the-addition-of-ezetimibe-to-statin-therapy-in-patients-with-acute-coronary-syndrome-in-improve-it
#6
Erin A Bohula, Stephen D Wiviott, Robert P Giugliano, Michael A Blazing, Jeong-Gun Park, Sabina A Murphy, Jennifer A White, Francois Mach, Frans J Van de Werf, Anthony J Dalby, Harvey D White, Andrew M Tershakovec, Christopher P Cannon, Eugene Braunwald
Background -Patients who experience an acute coronary syndrome (ACS) are at heightened risk of recurrent ischemic events, including stroke. Ezetimibe improved cardiovascular outcomes when added to statin therapy in patients stabilized after ACS. We investigated the efficacy of the addition of ezetimibe to simvastatin for the prevention of stroke and other adverse cardiovascular events in IMPROVE-IT, with a focus on patients with a stroke prior to randomization. Methods -Post-ACS patients were randomized to placebo/simvastatin or ezetimibe/simvastatin and followed for a median of 6 years...
September 30, 2017: Circulation
https://www.readbyqxmd.com/read/28967053/multifaceted-aseptic-protocol-decreases-surgical-site-infections-following-hip-arthroplasty
#7
Ryan E Harold, Bennet A Butler, Joseph Lamplot, Hue H Luu, Cort D Lawton, David Manning
INTRODUCTION: We investigate the effectiveness of a comprehensive aseptic protocol in reducing surgical site infection (SSI) after hip arthroplasty in a single medical centre with a high prevalence of methicillin-resistant Staphylococcus aureus (MRSA). METHODS: A prospectively collected database of all patients undergoing hip arthroplasty in a single centre between 2005 and 2011 was reviewed for SSI using Centers for Disease Control (CDC) criteria and AAOS guidelines...
September 21, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28964917/redox-imbalance-due-to-the-loss-of-mitochondrial-nad-p-transhydrogenase-markedly-aggravates-high-fat-diet-induced-fatty-liver-disease-in-mice
#8
Claudia D C Navarro, Tiago R Figueira, Annelise Francisco, Genoefa A Dal'Bó, Juliana A Ronchi, Juliana C Rovani, Cecilia A F Escanhoela, Helena C F Oliveira, Roger F Castilho, Anibal E Vercesi
The mechanisms by which a high fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) appear to involve liver mitochondrial dysfunctions and redox imbalance. We hypothesized that a HFD would increase mitochondrial reliance on NAD(P)-transhydrogenase (NNT) as the source of NADPH for antioxidant systems that counteract NAFLD development. Therefore, we studied HFD-induced liver mitochondrial dysfunctions and NAFLD in C57Unib.B6 congenic mice with (Nnt(+/+)) or without (Nnt(-/-)) NNT activity; the spontaneously mutated allele (Nnt(-/-)) was inherited from the C57BL/6J mouse substrain...
September 28, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28960384/randomized-controlled-trial-comparing-smartphone-assisted-versus-traditional-guided-self-help-for-adults-with-binge-eating
#9
Tom Hildebrandt, Andreas Michaelides, Dianna Mackinnon, Rebecca Greif, Lynn DeBar, Robyn Sysko
OBJECTIVE: Guided self-help treatments based on cognitive-behavior therapy (CBT-GSH) are efficacious for binge eating. With limited availability of CBT-GSH in the community, mobile technology offers a means to increase use of these interventions. The purpose of this study was to test the initial efficacy of Noom Monitor, a smartphone application designed to facilitate CBT-GSH (CBT-GSH + Noom), on study retention, adherence, and eating disorder symptoms compared to traditional CBT-GSH...
September 27, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28951263/prophylactic-negative-pressure-wound-therapy-after-cesarean-is-associated-with-reduced-risk-of-surgical-site-infection-a%C3%A2-systematic-review-and-meta-analysis
#10
REVIEW
Lulu Yu, Ryan J Kronen, Laura E Simon, Carolyn R T Stoll, Graham A Colditz, Methodius G Tuuli
OBJECTIVE: The objective of the study was to assess the effect of prophylactic negative-pressure wound therapy on surgical site infections and other wound complications in women after cesarean delivery. DATA SOURCES: We searched Ovid Medline, Embase, SCOPUS, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov. STUDY ELIGIBILITY CRITERIA: We included randomized controlled trials and observational studies comparing prophylactic negative-pressure wound therapy with standard wound dressing for cesarean delivery...
September 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28949077/primary-thromboprophylaxis-ptp-in-ambulatory-patients-with-lung-cancer-receiving-chemotherapy-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-rcts
#11
Kyaw Zin Thein, Sai-Ching J Yeung, Thein Hlaing Oo
BACKGROUND: Thromboembolism (TE) is a leading cause of death in cancer patients. Primary thromboprophylaxis (PTP) in ambulatory cancer patients receiving chemotherapy has been debated and considered to potentially improve survival by reducing TE occurrence. OBJECTIVE: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) in ambulatory lung cancer (LC) patients on chemotherapy to determine the benefit and risk of PTP with low-molecular-weight heparins (LMWHs)...
September 26, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28944276/verification-of-neonatal-tetanus-surveillance-systems-in-katsina-state-nigeria
#12
Shafique Sani Nass, Hadi Danawi, Loretta Cain, Monoj Sharma
BACKGROUND: The incidence and mortality rates of neonatal tetanus (NNT) remain underreported in Nigeria. The goal of the study was to compare the NNT prevalence and the mortality rates from the existing surveillance system and active surveillance of health facility records in 7 selected health facilities from 2010 to 2014 in Katsina State, Nigeria. METHODS: The study is a retrospective record review using extracted data from NNT records and analyzed using descriptive statistics...
January 2017: Health Services Research and Managerial Epidemiology
https://www.readbyqxmd.com/read/28936568/distracting-injury-defined-does-an-isolated-hip-fracture-constitute-a-distracting-injury-for-clearance-of-the-cervical-spine
#13
Ryan Lindborg, Amani Jambhekar, Vincent Chan, Daniel Laskey, James Rucinski, Bashar Fahoum
OBJECTIVES: As the population within the USA ages, the number of hip fractures seen yearly in the emergency department is expected to rise. According to the NEXUS criteria, many of these patients receive computerized tomographic scan (CT) evaluation of the cervical spine because a hip fracture may constitute a distracting injury. The objective of this study is to determine if an isolated hip fracture constitutes a distracting injury which requires imaging of the cervical spine. METHODS: Data were prospectively collected on 158 trauma patients with isolated hip fractures between April 1, 2015 and March 9, 2016...
September 21, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28929037/risk-of-death-from-prostate-cancer-with-and-without-definitive-local-therapy-when-gleason-pattern-5-is-present-a-surveillance-epidemiology-and-end-results-analysis
#14
Jonathan Frandsen, Andrew Orton, Dennis Shrieve, Jonathan Tward
Purpose The purpose is to evaluate the patterns of care and comparative effectiveness for cause-specific and overall survival of definitive local treatments versus conservatively managed men with a primary or secondary Gleason pattern of 5. Methods and materials Patients diagnosed from 2004 to 2012 with a primary or secondary Gleason pattern of 5 N0M0 prostate cancer were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier and Cox regression analyses were used to estimate the survival...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28921813/what-is-the-safest-mode-of-birth-for-extremely-preterm-breech-singleton-infants-who-are-actively-resuscitated-a-systematic-review-and-meta-analyses
#15
Marinela Grabovac, Jehan N Karim, Tetsuya Isayama, Sugee Korale Liyanage, Sarah D McDonald
BACKGROUND: The safest delivery mode of extremely preterm breech singletons is unknown. OBJECTIVES: To determine safest delivery mode of actively resuscitated extremely preterm breech singletons. SEARCH STRATEGY: We searched Cochrane CENTRAL, MEDLINE, EMBASE, CINAHL and ClinicalTrials. gov from 1994-May 2017. SELECTION CRITERIA: We included studies comparing outcomes by delivery mode in actively resuscitated breech infants between 23(+0) -27(+6) weeks...
September 18, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28916164/-analysis-of-clinical-relevance-applied-to-3methods-of-reducing-weight-in-overweight-or-obesity-followed-up-for-one-year
#16
M L Tárraga Marcos, J M Panisello Royo, J A Carbayo Herencia, N Rosich Domenech, J Alins Presas, E Castell Panisello, P J Tárraga López
OBJECTIVE: To analyse the effect of the use/implementation of 3methods to reduce weight in overweight or obese patients during one year of follow up. MATERIAL AND METHODS: The design corresponds to a double-blind, randomised, controlled clinical trial with 3arms, and 12 months of follow-up. Patients were randomised into 3intervention groups: obesity motivational intervention, with a nurse previously trained in motivational intervention by expert psychologists (G1; n=60); lower intensity consultation, non-motivational group, with digital platform support (G2; N=61), and a third group that received recommendations for weight loss and follow-up in Primary Care Clinic (G3; n=59)...
September 12, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/28885895/meta-analysis-of-comparative-trials-evaluating-a-prophylactic-single-use-negative-pressure-wound-therapy-system-for-the-prevention-of-surgical-site-complications
#17
Vicki Strugala, Robin Martin
BACKGROUND: We report the first meta-analysis on the impact of prophylactic use of a specific design of negative pressure wound therapy (NPWT) device on surgical site complications. METHODS: Articles were identified in which the specific single-use NPWT device (PICO(⋄), Smith & Nephew) was compared with standard care for surgical site infection (SSI), dehiscence, or length of stay (LOS). Risk ratio (RR) ±95% confidence interval (CI) (SSI; dehiscence) or mean difference in LOS ±95% CI was calculated using RevMan v5...
October 2017: Surgical Infections
https://www.readbyqxmd.com/read/28876613/management-and-outcomes-from-appendectomy-an-international-prospective-multicentre-study
#18
J Camilleri-Brennan, T Drake, R Spence, A Bhangu, E Harrison
BACKGROUND: To identify variation in surgical management and outcomes of appendicitis across low, middle and high Human Development Index (HDI) country groups. METHOD: Multi-centre, international prospective cohort study of consecutive patients undergoing emergency appendectomy over a 6-month period. Follow-up lasted 30 days. Primary outcome measure was overall complication rate. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high, 1540 middle and 507 low HDI groups)...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28874642/measurement-of-crestal-cortical-bone-thickness-at-implant-site-a-cone-beam-computed-tomography-study
#19
Ajai Gupta, Suprabha Rathee, Jaihans Agarwal, Renu B Pachar
AIM: Dental implants have emerged as a new treatment modality for the majority of patients complaining of missing teeth. Bone quantity and bone quality are among various factors which ensure the longevity of dental implant in the patient's mouth. The assessment of cortical bone thickness of the outer layer and the cancellous bone density by cone beam computed tomography (CBCT) has proved beneficial for the patient. This study aimed at presurgical measurement of crestal bone thickness at various implant sites using CBCT images...
September 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28874385/do-studies-calculate-the-nnt-appropriately
#20
(no author information available yet)
No abstract text is available yet for this article.
September 5, 2017: Drug and Therapeutics Bulletin
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