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https://www.readbyqxmd.com/read/29644412/patent-foramen-ovale-closure-versus-medical-therapy-for-prevention-of-recurrent-cryptogenic-embolism-updated-meta-analysis-of-randomized-clinical-trials
#1
Brunilda Alushi, Alexander Lauten, Salvatore Cassese, Roisin Colleran, Stefanie Schüpke, Himanshu Rai, Heribert Schunkert, Bernhard Meier, Ulf Landmesser, Adnan Kastrati
BACKGROUND: We performed an updated meta-analysis of all randomized-controlled trials (RCTs) comparing patent foramen ovale (PFO) closure with medical therapy for prevention of recurrent ischemic stroke. METHODS AND RESULTS: We searched Medline, EMBASE, and Cochrane databases, and proceedings of international meetings for RCTs of patients with cryptogenic stroke and PFO comparing percutaneous PFO closure versus medical therapy for prevention of recurrent ischemic stroke...
April 11, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29623148/diclofenac-potassium-in-acute-postoperative-pain-and-dysmenorrhoea-results-from-comprehensive-clinical-trial-reports
#2
REVIEW
R Andrew Moore, Sheena Derry
We compared the efficacy of diclofenac potassium in unpublished clinical study reports (CSRs) and published reports to examine publication bias, industry bias, and comprehensiveness. Novartis provided CSRs of randomised double-blind trials of diclofenac potassium involving postoperative patients following third molar extraction (3 trials, n =519), gynaecological surgery (3 trials, n =679), and dysmenorrhoea (2 trials, n =711) conducted in 1988-1990. Searches identified published reports of 6 trials. Information from 599/1909 patients was not published; trials with 846/1909 patients were published in a defunct journal...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29619856/number-needed-to-treat-and-costs-per-responder-among-biologic-treatments-for-moderate-to-severe-psoriasis-a-network-meta-analysis
#3
April W Armstrong, Keith A Betts, James E Signorovitch, Murali Sundaram, Junlong Li, Arijit X Ganguli, Eric Q Wu
BACKGROUND: The clinical benefits of biologic therapies for moderate-to-severe psoriasis are well established, but wide variations exist in patient response. OBJECTIVES: To determine the number needed to treat (NNT) to achieve a 75% and 90% reduction in the Psoriasis Area and Severity Index (PASI-75/90) with FDA-approved agents and evaluate the incremental cost per PASI-75 or PASI-90 responder. METHODS: The relative probabilities of achieving PASI-75 and PASI-90, as well as NNTs were estimated using a network meta-analysis...
April 5, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29607580/effectiveness-of-antenatal-perineal-massage-in-reducing-perineal-trauma-and-post-partum-morbidities-a-randomized-controlled-trial
#4
Emmanuel Onyebuchi Ugwu, Eric Sunday Iferikigwe, Samuel Nnamdi Obi, George Uchenna Eleje, Benjamin Chukwuma Ozumba
AIM: The study aimed to evaluate the effectiveness of antenatal perineal massage (APM) in reducing perineal trauma and post-partum morbidities. METHODS: A randomized controlled trial of 108 primigravidae at the University of Nigeria Teaching Hospital, Enugu, Nigeria, was conducted from January 2013 to May 2014. The intervention group received APM, while the control group did not receive APM. RESULTS: Women who received APM were significantly more likely to have an intact perineum after childbirth [27/53 (50...
April 2, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29587729/comparing-the-efficacy-of-targeted-spinal-cord-stimulation-scs-of-the-dorsal-root-ganglion-with-conventional-medical-management-cmm-in-patients-with-chronic-post-surgical-inguinal-pain-the-smashing-trial
#5
Frederique M U Mol, Rudi M Roumen, Marc R Scheltinga
BACKGROUND: A significant number of patients who undergo a standard inguinal hernia repair or a Pfannenstiel incision develop chronic (> 3 months) post-surgical inguinal pain (PSIP) due to nerve entrapment. If medication or peripheral nerve blocks fail, surgery including neurectomies may offer relief. However, some patients do not respond to any of the currently available remedial treatment modalities. Targeted spinal cord stimulation (SCS) of the dorsal root ganglion (DRG) is a relatively new type of therapy that has a potential to significantly reduce chronic PSIP...
March 27, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29568015/single-dose-oral-prednisolone-and-post-operative-endodontic-pain
#6
Analia Veitz-Keenan, Debra M Ferraiolo
DesignA randomised, single centre, double blind placebo controlled clinical trial involving 400 patients.InterventionThe inclusion criteria comprised systemically healthy patients between the ages of 18 and 35 years having mandibular molars with symptomatic irreversible pulpitis, radiographically normal periapical area and no pain on biting or percussion. The study was approved by the Institutional Review Board of Ethics Committee at the School of Dentistry, Cairo University, Egypt. Patients were recruited from the outpatient clinic of the Department of Endodontics...
March 23, 2018: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29560146/radiographic-assessment-of-maxillary-sinus-lateral-wall-thickness-in-edentulous-posterior-maxilla
#7
Amir Kiakojori, Seyede Parisa Motamedi Nasab, Farida Abesi, Hemmat Gholinia
Background and aim: Given the importance of evaluating the maxillary sinus lateral wall thickness (LWT) to avoid complications during surgery, the aim of this study was to examine LWT as well as the effect of residual ridge height (RH), edentulous region, type of edentulism, age and gender on it. Methods: In this cross-sectional study conducted in 2016, 150 samples of the CBCT imaging archives of the Oral and Maxillofacial Radiology Clinic in Babol, Iran, were evaluated retrospectively...
December 2017: Electronic Physician
https://www.readbyqxmd.com/read/29550917/fifteen-year-outcomes-of-an-acute-medical-admission-unit
#8
Richard Conway, Declan Byrne, Seán Cournane, Deirdre O'Riordan, Bernard Silke
BACKGROUND: The Acute Medical Admission Unit (AMAU) model of care has been associated with improved short- and medium-term outcomes; whether these improvements are sustained remains unclear. We report on the 15-year outcomes of an AMAU in our institution. METHODS: All emergency medical admissions between 2002 and 2016 were examined and 30-day in-hospital mortality, admission rates, readmission rates and length of stay (LOS) assessed. We used logistic and Poisson regression and margin statistics to evaluate outcomes...
March 17, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29550218/which-antibiotic-regimen-prevents-implant-failure-or-infection-after-dental-implant-surgery-a-systematic-review-and-meta-analysis
#9
REVIEW
Fabio Rodríguez Sánchez, Carlos Rodríguez Andrés, Iciar Arteagoitia
OBJECTIVE: To assess which antibiotic regimen prevents dental implant failures or postoperative infections following dental implant placement. MATERIALS AND METHODS: Systematic review and meta-analysis. DATA SOURCES: Pubmed, Cochrane, Science Direct, and EMBASE via OVID were searched up to August 2017. Only randomized controlled clinical trials (RCT) using antibiotics were included. Outcome measures were set on dental implant failures or postoperative infection incidence after dental implant surgery...
February 26, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29537878/number-needed-to-treat-in-indirect-treatment-comparison
#10
Patricia Guyot, Wei Cheng, Gabriel Tremblay, Ronda Copher, Heather Burnett, Xuan Li, Charles Makin
AIM: For dichotomous outcomes, odds ratio (OR) is one of the usual summary measures of indirect treatment comparison. A corresponding number needed to treat (NNT) estimate may facilitate understanding of the treatment effect. METHODS: We show how to estimate NNT based on OR results of a matching adjusted indirect comparison. We also have derived the explicit formula of its 95% CIs by applying the delta method, and as an alternative, a simulation-based method. RESULTS: The method was applied in a case study example in radioiodine-refractory differentiated thyroid cancer (RR-DTC) patients, comparing lenvatinib to sorafenib...
March 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29522941/validating-pre-treatment-body-mass-index-as-moderator-of-antidepressant-treatment-outcomes-findings-from-co-med-trial
#11
Manish K Jha, Shereen Wakhlu, Neha Dronamraju, Abu Minhajuddin, Tracy L Greer, Madhukar H Trivedi
BACKGROUND: Currently, there are no valid clinical or biological markers to personalize the treatment of depression. Recent evidence suggests that body mass index (BMI) may guide the selection of antidepressant medications with different mechanisms of action. METHODS: Combining Medications to Enhance Depression Outcomes (CO-MED) trial participants with BMI measurement (n = 662) were categorized as normal- or underweight (<25), overweight (25-<30), obese I (30-<35), and obese II+ (≥35)...
February 27, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29521686/do-immediate-postoperative-radiographs-change-patient-management-after-fracture-fixation-a-systematic-review
#12
Tammie Teo, Emily Schaeffer, Anthony Cooper, Kishore Mulpuri
OBJECTIVES: To evaluate whether immediate (0-3 day) postoperative radiography leads to alterations in management for patients post-fracture fixation. DATA SOURCES: Systematic review of English-language articles in the MEDLINE (1946-2016), EMBASE (1974-2016), CDSR (2005-2016), CENTRAL (1948-2016) and Google Scholar databases using PRISMA guidelines. STUDY SELECTION: Randomized or non-randomized controlled trials and prospective or retrospective cohort studies that addressed surgical management of upper extremity, lower extremity or hip fractures were eligible for review...
February 20, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29518771/overexpression-of-long-non-coding-rna-nnt-as1-correlates-with-tumor-progression-and-poor-prognosis-in-osteosarcoma
#13
Hui Ye, Jinkuang Lin, Xuedong Yao, Yizhong Li, Xiaobin Lin, Hai Lu
BACKGROUND/AIMS: Increasing evidence demonstrates that long non-coding RNAs (lncRNAs) play critical regulatory roles in cancers, including osteosarcoma. A previous study showed that Nicotinamide Nucleotide Transhydrogenase-antisense RNA1 (NNT-AS1) was aberrantly expressed in several types of cancer. However, the potential biological roles and regulatory mechanisms of NNT-AS1 in osteosarcoma progression remain unknown. METHODS: Quantitative RT-PCR was performed to examine the expression of NNT-AS1 in human tissues and cells...
March 2, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29506674/the-european-and-chinese-cardiac-and-renal-remote-ischemic-preconditioning-study-euro-crips-cardiogroup-i-a-randomized-controlled-trial
#14
Claudio Moretti, Enrico Cerrato, Erika Cavallero, Song Lin, Marco Luciano Rossi, Andrea Picchi, Francesca Sanguineti, Fabrizio Ugo, Alberto Palazzuoli, Maurizio Bertaina, Patrizia Presbitero, Chen Shao-Liang, Roberto Pozzi, Massimo Giammaria, Ugo Limbruno, Thierry Lefèvre, Valeria Gasparetto, Roberto Garbo, Pierluigi Omedè, Imad Sheiban, Javier Escaned, Giuseppe Biondi-Zoccai, Fiorenzo Gaita, Leor Perl, Fabrizio D'Ascenzo
BACKGROUND: The potential protective effects of remote ischemic preconditioning (RIPC) on contrast-induced nephropathy (CIN) after percutaneous coronary intervention (PCI) remain to be defined. METHODS AND RESULTS: A double blind, randomized, placebo controlled multicenter study was performed. Patients younger than 85years old, with a renal clearance of 30-60ml/min/1.73m2 , who were candidates for PCI for all clinical indications except for primary PCI, were allocated 1:1 to RIPC or to standard therapy...
April 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29488150/stroke-prevention-with-oral-anticoagulants-summary-of-the-evidence-and-efficacy-measures-as-an-aid-to-treatment-choices
#15
REVIEW
José Francisco Kerr Saraiva
Atrial fibrillation (AF) is an established risk factor for a first or recurrent stroke. Despite proven efficacy in preventing stroke in patients with AF, warfarin is underused, partly due to safety concerns. Recent randomized trials have shown that non-vitamin K antagonist oral anticoagulants (NOACs) such as dabigatran (a direct thrombin inhibitor) and apixaban, edoxaban, and rivaroxaban (factor Xa inhibitors) are not only non-inferior or superior to warfarin but also demonstrate a decreased risk of cerebrovascular bleeding among patients with AF and moderate to high risk of stroke...
February 27, 2018: Cardiology and Therapy
https://www.readbyqxmd.com/read/29482625/yield-of-tuberculosis-among-household-contacts-of-tuberculosis-patients-in-accra-ghana
#16
Sally-Ann Ohene, Frank Bonsu, Nii Nortey Hanson-Nortey, Adelaide Sackey, Samuel Danso, Felix Afutu, Paul Klatser, Mirjam Bakker
BACKGROUND: The End TB Strategy calls for systematic screening of selected high-risk groups including contacts of tuberculosis (TB) cases to facilitate early TB case detection. Contact investigation is not usually routinely practiced in low TB burden countries, such as Ghana, with consequent paucity of data on the yield of TB case detection from such interventions. This study's objective was to document the outcomes and feasibility of implementing contact investigation activities under programmatic conditions in Ghana...
February 27, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29479827/baclofen-its-effectiveness-in-reducing-harmful-drinking-craving-and-negative-mood-a-meta-analysis
#17
REVIEW
Abigail K Rose, Andrew Jones
BACKGROUND AND AIMS: There are a limited number of pharmacotherapies licensed for alcohol use disorders (AUDs). Baclofen is a GABA-B agonist which is increasingly used as an off label treatment. A meta-analysis of randomised controlled trials (RCTs) was conducted to determine the efficacy of baclofen in reducing drinking behaviour, craving, depression, and anxiety, compared with placebo. METHODS: Random effects meta-analyses were computed on outcome data from 12 RCTs comparing baclofen with placebo...
February 26, 2018: Addiction
https://www.readbyqxmd.com/read/29472432/predicting-the-effect-of-fenofibrate-on-cardiovascular-risk-for-individual-patients-with-type-2-diabetes-mellitus
#18
Charlotte Koopal, Frank L J Visseren, Jan Westerink, Yolanda van der Graaf, Henry N Ginsberg, Anthony C Keech
OBJECTIVE: In clinical trials, treatment with fenofibrate did not reduce the incidence of major cardiovascular events (MCVE) in patients with type 2 diabetes mellitus (T2DM). However, treatment effects reported by trials comprise patients who respond poorly and patients who respond well to fenofibrate. Our aim was to use statistical modeling to estimate the expected treatment effect of fenofibrate for individual patients with T2DM. RESEARCH DESIGN AND METHODS: To estimate individual risk, the FIELD risk model, with 5-year MCVE as primary outcome, was externally validated in T2DM patients from ACCORD and the SMART observational cohort...
February 22, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29460712/rhythmic-low-field-magnetic-stimulation-may-improve-depression-by-increasing-brain-derived-neurotrophic-factor
#19
Le Xiao, Christoph U Correll, Lei Feng, Yu-Tao Xiang, Yuan Feng, Chang-Qing Hu, Rena Li, Gang Wang
BACKGROUND: Low-field magnetic stimulation (LFMS) has mood-elevating effect, and the increase of brain-derived neurotrophic factor (BDNF) is associated with antidepressant treatment. We evaluated the effects and association with BDNF of rhythmic LFMS in the treatment of major depressive disorder (MDD). METHODS: A total of 22 MDD patients were randomized to rhythmic alpha stimulation (RAS) or rhythmic delta stimulation (RDS), with 5 sessions per week, lasting for 6 weeks...
February 20, 2018: CNS Spectrums
https://www.readbyqxmd.com/read/29455203/absence-of-nicotinamide-nucleotide-transhydrogenase-in-c57bl-6j-mice-exacerbates-experimental-atherosclerosis
#20
Aimee E Vozenilek, Matthew Vetkoetter, Jonette M Green, Xinggui Shen, James G Traylor, Ronald L Klein, A Wayne Orr, Matthew D Woolard, David M Krzywanski
BACKGROUND: Mitochondrial reactive oxygen species (ROS) contribute to inflammation and vascular remodeling during atherosclerotic plaque formation. C57BL/6N (6N) and C57BL/6J (6J) mice display distinct mitochondrial redox balance due to the absence of nicotinamide nucleotide transhydrogenase (NNT) in 6J mice. We hypothesize that differential NNT expression between these animals alters plaque development. METHODS: 6N and 6J mice were treated with AAV8-PCSK9 (adeno-associated virus serotype 8/proprotein convertase subtilisin/kexin type 9) virus leading to hypercholesterolemia, increased low-density lipoprotein, and atherosclerosis in mice fed a high-fat diet (HFD)...
February 16, 2018: Journal of Vascular Research
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