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https://www.readbyqxmd.com/read/28318619/effect-on-the-lipid-parameters-of-an-intervention-to-reduce-weight-in-overweight-and-obese-patients
#1
M Loreto Tárraga Marcos, Josefa María Panisello Royo, Julio A Carbayo Herencia, Nuria Rosich Domenech, Josep Alins Presas, Pedro J Tárraga López
OBJECTIVE: To assess the effect on lipid parameters most associated with excess weight (triglycerides [TG], cholesterol, and high density lipoprotein [HDL-C]) of an intervention to reduce weight in overweight and obese patients. METHODS: A randomised, controlled, double blind clinical trial, with three groups, and a follow-up of 12 months. Patients included in the study were randomised into three intervention groups: Obesity motivational intervention group with previously trained nurse (G1), lower intensity consultation, non-motivational group, with digital platform support (G2), and a third group that received a recommendation to lose weight and usual follow-up (G3)...
March 16, 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/28298025/outcome-after-hunt-and-hess-grade-v-subarachnoid-hemorrhage-a-comparison-of-pre-coiling-era-1980-1995-versus-post-isat-era-2005-2014
#2
Juergen Konczalla, Volker Seifert, Juergen Beck, Erdem Güresir, Hartmut Vatter, Andreas Raabe, Gerhard Marquardt
OBJECTIVE Outcome analysis of comatose patients (Hunt and Hess Grade V) after subarachnoid hemorrhage (SAH) is still lacking. The aims of this study were to analyze the outcome of Hunt and Hess Grade V SAH and to compare outcomes in the current period with those of the pre-International Subarachnoid Aneurysm Trial (ISAT) era as well as with published data from trials of decompressive craniectomy (DC) for middle cerebral artery (MCA) infarction. METHODS The authors analyzed cases of Hunt and Hess Grade V SAH from 1980-1995 (referred to in this study as the earlier period) and 2005-2014 (current period) and compared the results for the 2 periods...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28291972/efficacy-safety-and-tolerability-of-augmentative-rtms-in-treatment-of-major-depressive-disorder-mdd-a-prospective-cohort-study-in-croatia
#3
Igor Filipcic, Zeljko Milovac, Strahimir Sucic, Tomislav Gajsak, Ivona Simunovic Filipcic, Ena Ivezic, Vjekoslav Aljinovic, Ivana Orgulan, Sandra Zecevic Penic, Zarko Bajic
BACKGROUND: An increasing body of research suggest that repetitive Transcranial Magnetic Stimulation (rTMS) is effective and safe treatment option for patients with major depressive disorder (MDD). The Psychiatric Hospital "Sveti Ivan" has the first TMS laboratory with rTMS and deep TMS (dTMS) in Croatia. The objective of this study was to assess the efficacy, safety and tolerability of augmentative rTMS treatment vs standard treatment in Croatian patients with major depressive disorder (MDD)...
March 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28286710/the-complete-chloroplast-genome-sequence-of-morus-cathayana-and-morus-multicaulis-and-comparative-analysis-within-genus-morus-l
#4
Wei Qing Kong, Jin Hong Yang
Trees in the Morus genera belong to the Moraceae family. To better understand the species status of genus Morus and to provide information for studies on evolutionary biology within the genus, the complete chloroplast (cp) genomes of M. cathayana and M. multicaulis were sequenced. The plastomes of the two species are 159,265 bp and 159,103 bp, respectively, with corresponding 83 and 82 simple sequence repeats (SSRs). Similar to the SSRs of M. mongolica and M. indica cp genomes, more than 70% are mononucleotides, ten are in coding regions, and one exhibits nucleotide content polymorphism...
2017: PeerJ
https://www.readbyqxmd.com/read/28286561/systematic-review-and-meta-analysis-the-effects-of-fermented-milk-with-bifidobacterium-lactis-cncm-i-2494-and-lactic-acid-bacteria-on-gastrointestinal-discomfort-in-the-general-adult-population
#5
REVIEW
Jacqui Eales, Peter Gibson, Peter Whorwell, John Kellow, Ann Yellowlees, Richard H J Perry, Mary Edwards, Sarah King, Hannah Wood, Julie Glanville
BACKGROUND: It has been suggested that probiotics may improve gastrointestinal discomfort. Not all probiotics exhibit the same effects and consequently meta-analyses on probiotics should be confined to well-defined strains or strain combinations. The aim of this study was to evaluate the effectiveness of a probiotic fermented milk (PFM) that includes Bifidobacterium lactis (B. lactis) CNCM I-2494 and lactic acid bacteria on gastrointestinal discomfort in the general adult population. METHODS: Double-blind randomized controlled trials in the general adult population comparing PFM with a control dairy product for at least 4 weeks were searched from multiple literature databases (up to February 2015)...
January 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28286071/bosniak-classification-for-complex-renal-cysts-re-evaluated-a-systematic-review
#6
REVIEW
Ivo G Schoots, Keren Zaccai, Myriam G Hunink, Paul C M S Verhagen
OBJECTIVE: To systematically evaluate the Bosniak classification, with malignancy rates of each Bosniak category, and to assess the effectiveness related to surgical treatment and oncological outcome, based on recurrence and/or metastasis. METHODS: A systematic review (according to the PRISMA statement and the QUADAS-2 criteria) selected 39 publications for inclusion in this analysis and categorised into: 1) "surgical" cohorts- all cysts underwent surgery, and 2) "radiological" cohorts- cysts underwent either surgical treatment or radiological follow-up...
March 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28281367/a-review-of-the-literature-antibiotic-usage-and-its-relevance-to-the-infection-in-periodontal-flaps
#7
Yiying Liu, Dingyu Duan, Yuejiao Xin, Lin Bai, Tianyu Li, Chuwen Li, Yi Xu
OBJECTIVE: This study aimed to investigate the systemic antibiotic usage in the perioperative period of periodontal flaps and its relevance to the infection after surgeries through reviewing the papers of the last decade. MATERIALS AND METHODS: A search was conducted for the studies of randomized clinical trials between 2005 and 2014 that reported periodontal flaps in chronic periodontitis patients. Data were extracted and the rate of the systemic antibiotic use, the infection rate after surgeries and the number needed to treat (NNT) to prevent one infected case were calculated...
March 10, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28279597/inferior-vena-cava-filters-in-pulmonary-embolism-a-historic-controversy
#8
Carlos Jerjes-Sanchez, David Rodriguez, Aline Navarrete, Carolina Parra-Cantu, Jorge Joya-Harrison, Eduardo Vazquez, Alicia Ramirez-Rivera
OBJECTIVE: Rationale for non-routine use of inferior venous cava filters (IVCF) in pulmonary embolism (PE) patients. METHODS: Thrombosis mechanisms involved with IVCF placement and removal, the blood-contacting medical device inducing clotting, and the inorganic polyphosphate in the contact activation pathway were analyzed. In addition, we analyzed clinical evidence from randomized trials, including patients with and without cancer. Furthermore, we estimated the absolute risk reduction (ARR), the relative risk reduction (RRR), and the number needed to treat (NNT) based on the results of each study using a frequency table...
March 6, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28276627/exercise-and-sleep-a-systematic-review-of-previous-meta-analyses
#9
George A Kelley, Kristi Sharpe Kelley
OBJECTIVE: Conduct a systematic review of previous meta-analyses on exercise and sleep outcomes in adults and a meta-analysis of studies nested within these meta-analyses. METHODS: Meta-analyses of randomized controlled exercise interventions were included by searching 9 electronic databases and cross-referencing. Dual-selection and data abstraction were conducted. Methodological quality of meta-analyses was assessed using AMSTAR and quality of evidence using GRADE...
November 16, 2016: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/28276624/community-deliverable-exercise-and-depression-in-adults-with-arthritis-confirmatory-evidence-of-a-meta-analysis-using-the-ivhet-model
#10
George A Kelley, Kristi S Kelley
OBJECTIVE: Using the traditional random-effects model, a recently reported standardized effect size (g) reduction of -0.42 (95% CI, -0.58 to -0.27) was observed as a result of community-deliverable exercise in adults with arthritis and other rheumatic diseases (AORD). However, a recently proposed alternative model (IVhet) has been shown to have superior coverage probability to the random-effects model. The purpose of this brief report was to compare these previous random-effects results with the IVhet model...
August 29, 2016: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/28276151/effectiveness-of-progesterone-cerclage-and-pessary-for-preventing-preterm-birth-in-singleton-pregnancies-a-systematic-review-and-network-meta-analysis
#11
Alexander Jarde, Olha Lutsiv, Christina K Park, Joseph Beyene, Jodie M Dodd, Jon Barrett, Prakesh S Shah, Jocelynn L Cook, Shigeru Saito, Anne B Biringer, Lisa Sabatino, Lucy Giglia, Zhen Han, Katharina Staub, William Mundle, Jean Chamberlain, Sarah D McDonald
BACKGROUND: Preterm birth (PTB) is the leading cause of infant death, but it is unclear which intervention is best to prevent it. OBJECTIVES: To compare progesterone, cerclage and pessary, determine their relative effects and rank them. SEARCH STRATEGY: We searched Medline, EMBASE, CINAHL, Cochrane CENTRAL, and Web of Science (to April 2016), without restrictions, and screened references of previous reviews. SELECTION CRITERIA: We included randomised trials of progesterone, cerclage or pessary for preventing PTB in women with singletons at risk as defined by each study...
March 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28271733/evaluating-drug-cost-per-responder-and-number-needed-to-treat-associated-with-lixisenatide-on-top-of-glargine-when-compared-to-rapid-acting-insulin-intensification-regimens-on-top-of-glargine-in-patients-with-type-2-diabetes-in-uk-italy-and-spain
#12
Marion Afonso, Fay Ryan, Ashley Pitcher, Elisheva Lew
OBJECTIVES: This study investigated the cost per responder and number needed to treat (NNT) in type 2 diabetes mellitus (T2DM) patients for lixisenatide compared to insulin intensification regimens using composite endpoints in the UK, Italy, and Spain. METHODS: Efficacy and safety outcomes were obtained from GetGoal Duo-2, a 26-week phase 3 trial comparing lixisenatide versus insulin glulisine (IG) once daily (QD) and three times daily (TID). Response at week 26 was extrapolated to 52 weeks assuming a maintained treatment effect, based on long-term evidence in other T2DM populations...
March 8, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28253404/protective-role-of-orthokeratology-in-reducing-risk-of-rapid-axial-elongation-a-reanalysis-of-data-from-the-romio-and-to-see-studies
#13
Pauline Cho, Sin-Wan Cheung
Purpose: To determine the relative risk of rapid progression and number needed to treat (NNT) in younger and older children using combined data from the retardation of myopia in orthokeratology (ROMIO) and toric orthokeratology-slowing eye elongation (TO-SEE) studies. Methods: Data from 136 subjects of two studies, ROMIO and TO-SEE, were retrieved (72 orthokeratology [ortho-k]: 37 ROMIO, 35 TO-SEE; 64 control: 41 ROMIO, 23 TO-SEE) and the myopia control effect on younger (6-8 years) and older (9-12 years) subjects evaluated...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28230312/five-year-cost-effectiveness-of-patient-empowerment-programme-pep-for-type-2-diabetes-mellitus-in-primary-care
#14
J X Lian, Sarah M McGhee, C So, J Chau, Carlos Kh Wong, William Cw Wong, Cindy Lk Lam
This study evaluated the short-term cost-effectiveness of the Patient Empowerment Programme (PEP) for diabetes mellitus in Hong Kong. Propensity score matching was used to select a matched group of PEP and non-PEP subjects. A societal perspective was adopted to estimate the cost of PEP. The outcome measures were the cumulative incidence of all-cause mortality and diabetic complication over a five-year follow-up and the number needed to treat (NNT) to avoid one event. The incremental cost-effectiveness ratio (ICER) of cost per event avoided was calculated using the PEP cost per subject multiplied by the NNT...
February 23, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28225220/efficacy-of-ruscus-extract-hmc-and-vitamin-c-constituents-of-cyclo-3-fort%C3%A2-on-improving-individual-venous-symptoms-and-edema-a-systematic-review-and-meta-analysis-of-randomized-double-blind-placebo-controlled-trials
#15
Stavros K Kakkos, François A Allaert
INTRODUCTION: Venoactive drugs (VADs) are considered an important component of the medical (conservative) treatment of chronic venous disorders (CVDs). However, the efficacy of certain VADs on one or more individual leg symptoms may have not been extensively studied to justify a high level or grade of recommendation in guidelines on CVD. The aim of the present systematic review and meta-analysis was to study the effectiveness of VADs containing Ruscus across the spectrum of defined venous symptoms...
April 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28213170/non-response-at-week-4-as-clinically-useful-indicator-for-antidepressant-combination-in-major-depressive-disorder-a-sequential-rct
#16
Masaki Kato, Yoshiteru Takekita, Yosuke Koshikawa, Shiho Sakai, Hiroki Bandou, Keiichiro Nishida, Naotaka Sunada, Ai Onohara, Yoshiyuki Hatashita, Alessandro Serretti, Toshihiko Kinoshita
We aimed to compare the efficacy and tolerability of mirtazapine versus SSRIs and to assess whether "non-response at week 4" may be a clinical indicator for combining mirtazapine and SSRIs for subsequent treatment. One-hundred fifty-four outpatients with MDD were randomized to receive mirtazapine or SSRIs in step I (4 weeks). Non-responders in step I were randomly assigned to either mirtazapine or SSRIs monotherapy or their combination in step IIa while responders in step I continued the same monotherapy in step IIb for 4 weeks...
February 3, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28209488/postoperative-maintenance-levonorgestrel-releasing-intrauterine-system-and-endometrioma-recurrence-a%C3%A2-randomized-controlled-study
#17
Yi-Jen Chen, Teh-Fu Hsu, Ben-Shian Huang, Hsiao-Wen Tsai, Yen-Hou Chang, Peng-Hui Wang
BACKGROUND: According to 3 randomized trials, the levonorgestrel-releasing intrauterine system significantly reduced recurrent endometriosis-related pelvic pain at postoperative year 1. Only a few studies have evaluated the long-term effectiveness of the device for preventing endometrioma recurrence, and the effects of a levonorgestrel-releasing intrauterine system as a maintenance therapy remain unclear. OBJECTIVE: The objective of the study was to evaluate whether a maintenance levonorgestrel-releasing intrauterine system is effective for preventing postoperative endometrioma recurrence...
February 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28185319/gabapentenoids-in-pain-management-in-urological-chronic-pelvic-pain-syndrome-gabapentin-or-pregabalin
#18
Mayank Mohan Agarwal, Mudelin Elsi Sy
AIMS: To compare efficacy of gabapentin and pregabalin in patients with urological chronic pelvic-pain syndrome (UCPPS). METHODS: Design-retrospective, setting-urology outpatient services of a secondary-care private hospital, inclusion criteria-men 18-50 years, presenting with pelvic pain (lower abdomen, groin, scrotum, perineum, low-back, hip) with or without lower urinary tract symptoms for at least 3 months duration. Hospital database was searched using keywords for neuropathic pain (ICD9-729...
February 10, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28176964/efficacy-and-safety-of-biological-and-targeted-synthetic-dmards-a-systematic-literature-review-informing-the-2016-update-of-the-asas-eular-recommendations-for-the-management-of-axial-spondyloarthritis
#19
Alexandre Sepriano, Andrea Regel, Désirée van der Heijde, Jürgen Braun, Xenofon Baraliakos, Robert Landewé, Filip Van den Bosch, Louise Falzon, Sofia Ramiro
OBJECTIVES: To update the evidence for the efficacy and safety of (b)biological and (ts)targeted-synthetic disease-modifying anti-rheumatic drugs (DMARDs) in patients with axial spondyloarthritis (axSpA) to inform the 2016 update of the Assessment of SpondyloArthritis international Society/European League Against Rheumatism (ASAS/EULAR) recommendations for the management of axSpA. METHODS: Systematic literature review (2009-2016) for randomised controlled trials (RCT), including long-term extensions, strategy trials and observational studies (the latter was only for safety assessment and a comparator was required)...
2017: RMD Open
https://www.readbyqxmd.com/read/28176189/number-needed-to-treat-in-multiple-sclerosis-clinical-trials
#20
REVIEW
Macaulay Okwuokenye, Annie Zhang, Amy Pace, Karl E Peace
Clinicians are expected to select a therapy based on their appraisal of evidence on benefit-to-risk profiles of therapies. In the management of relapsing-remitting multiple sclerosis (RRMS), evidence is typically expressed in terms of risk (proportion) of event, risk reduction, relative and hazard rate reduction, or relative reduction in the mean number of magnetic resonance imaging lesions. Interpreting treatment effect using these measures from a RRMS clinical trial is fairly reliable; however, this might not be the case when treatment effect is expressed in terms of the number needed to treat (NNT)...
February 7, 2017: Neurology and Therapy
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