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Drug resistant epilepsy

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https://www.readbyqxmd.com/read/28633983/corrigendum-to-cost-utility-of-video-electroencephalography-monitoring-followed-by-surgery-in-adults-with-drug-resistant-focal-epilepsy-in-thailand-world-neurosurgery-98-2017-750-760
#1
Pimprapa Kitwitee, Kanjana Unnwongse, Teeradej Srikijvilaikul, Tinonkorn Yadee, Chulaporn Limwattananon
No abstract text is available yet for this article.
June 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28633092/epilepsy-in-neurofibromatosis-type-1
#2
Anthony Pecoraro, Eric Arehart, William Gallentine, Rodney Radtke, Edward Smith, Carolyn Pizoli, Sujay Kansagra, Elie Abdelnour, Roger McLendon, Mohamad A Mikati
OBJECTIVES: To describe the characteristics of epilepsy in patients with Neurofibromatosis type 1 (NF1). METHODS: Analysis of a cohort of consecutive NF1 patients seen in our NF1 clinic during a three-year period. RESULTS: Of the 184 NF1 patients seen during that period, 26 had epilepsy and three had febrile seizures. Of the 26, 17 (65%) had localization-related epilepsy, seven of whom (41%) were drug resistant. Six (23%) had apparently primary generalized epilepsy (0/6 drug resistant), two (8%) Lennox-Gastaut syndrome, and one (4%) West syndrome (all three were drug-resistant)...
June 17, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28627626/hmgb1-regulates-p-glycoprotein-expression-in-status-epilepticus-rat-brains-via-the-rage-nf-%C3%AE%C2%BAb-signaling-pathway
#3
Yuan Xie, Nian Yu, Yan Chen, Kang Zhang, Hai-Yan Ma, Qing Di
Overexpression of P-glycoprotein (P-gp) in the brain is an important mechanism involved in drug‑resistant epilepsy (DRE). High-mobility group box 1 (HMGB1), an inflammatory cytokine, significantly increases following seizures and may be involved in upregulation of P‑gp. However, the underlying mechanisms remain elusive. The aim of the present study was to evaluate the role of HMGB1 and its downstream signaling components, receptor for advanced glycation end‑product (RAGE) and nuclear factor‑κB (NF‑κB), on P‑gp expression in rat brains during status epilepticus (SE)...
June 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28625947/intracranial-investigation-of-a-patient-with-nodular-heterotopia-and-hippocampal-sclerosis-dealing-with-a-dual-pathology
#4
Lady Diana Ladino, Chelsea Dash, Adam Wu, Jose Francisco Tellez-Zenteno
The pre-operative assessment and surgical management of patients with dual pathology is challenging. We describe a patient with drug-resistant focal epilepsy with hippocampal sclerosis and extensive periventricular nodular heterotopia in the same hemisphere. The semiology, scalp EEG, and imaging were divergent, but the presence of focal interictal and ictal epileptic discharges of the putative ictal onset zone resulted in successful localization of the epileptogenic zone. A less aggressive resection was performed based on intracranial EEG recording...
June 12, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28623754/quality-of-life-mood-and-seizure-control-in-patients-with-brain-tumor-related-epilepsy-treated-with-lacosamide-as-add-on-therapy-a-prospective-explorative-study-with-a-historical-control-group
#5
Marta Maschio, Alessia Zarabla, Andrea Maialetti, Alessandra Fabi, Antonello Vidiri, Veronica Villani, Diana Giannarelli
OBJECTIVE: Brain tumor-related epilepsy (BTRE) is often drug resistant and patients can be forced to take polytherapy that can adversely affect their quality of life (QoL). Lacosamide (LCM) is a new antiepileptic drug (AED) used as adjunctive therapy in patients with partial seizures with or without secondary generalization, with a favorable pharmacokinetic profile that seems to be effective and well tolerated. Therefore it represents a possible therapeutic choice for patients with BTRE...
June 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28623753/precuneal-epilepsy-clinical-features-and-surgical-outcome
#6
Adil Harroud, Olivier Boucher, Thi Phuoc Yen Tran, Louis Harris, Jeffery Hall, François Dubeau, Ismail Mohamed, Alain Bouthillier, Dang Khoa Nguyen
OBJECTIVE: The precuneus is a complex and highly connected structure located in the medial portion of the superior parietal lobule. The clinical presentation of precuneal epilepsy is poorly characterized, mostly because these patients have seldom been distinguished from those with other types of parietal lobe epilepsy. The present study aims to improve the understanding of precuneal epilepsy by detailing its clinical features and surgical outcomes. METHODS: Six previously unreported cases of drug-resistant precuneal epilepsy investigated between 2002 and 2014 were retrospectively studied...
June 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28623728/epilepsy-surgery-in-patients-older-than-50-years-effectiveness-safety-and-predictors-of-outcome
#7
Piergiorgio d' Orio, Veronica Pelliccia, Francesca Gozzo, Francesco Cardinale, Laura Castana, Giorgio Lo Russo, Gabriella Bottini, Pina Scarpa, Massimo Cossu
PURPOSE: Surgery is an effective treatment for drug resistant focal epilepsy. Predictors of seizure outcome have been extensively addressed in the general population but similar data on older patients are still lacking. The aim of this study is to evaluate effectiveness and safety of surgery for patients over 50 years and to investigate variables associated to seizure outcome. METHODS: We performed a single center retrospective study including 50 patients over 50 years treated surgically for drug resistant focal epilepsy between 1997 and 2014...
June 10, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28623489/comparing-the-intracarotid-amobarbital-test-and-functional-mri-for-the-presurgical-evaluation-of-language-in-epilepsy
#8
REVIEW
Andreu Massot-Tarrús, Seyed Reza Mousavi, Seyed M Mirsattari
Surgery is the treatment of choice for drug-resistant temporal lobe epilepsy (TLE). However, such surgery frequently causes deficits in language function, especially if performed on the dominant hemisphere. In recent years, the intracarotid amobarbital test (IAT) has been gradually replaced by functional magnetic resonance imaging (fMRI) in the preoperative identification of language areas to estimate the risk of postoperative language decline. In this paper, we review the neural substrates for language processing, how language impairment can result both from TLE itself and from surgical attempts to treat it...
July 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28619068/late-onset-jaw-and-teeth-pain-mimicking-trigeminal-neuralgia-associated-with-chronic-vagal-nerve-stimulation-case-series-and-review-of-the-literature
#9
Gabriela Timarova, Andrej Šteňo
BACKGROUND: Vagal nerve stimulation (VNS) for refractory epilepsy is well established. Trigeminal neuralgia itself is a common disease in adults, and thus, late-onset pain in the trigeminal region under VNS, which is extremely rare, may not be recognized as caused by VNS. CASE PRESENTATION: Two patients with drug-resistant symptomatic epilepsy treated with chronic VNS experienced stimulation-related pain in the lower and upper jaw and teeth on the side of stimulation...
June 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28608314/polymorphism-of-the-multidrug-resistance-1-gene-mdr1-g2677t-a-rs2032582-and-the-risk-of-drug-resistant-epilepsy-in-the-polish-adult-population
#10
Beata Smolarz, Dominik Skalski, Andrzej Rysz, Andrzej Marchel, Hanna Romanowicz, Marianna Makowska
The aim of this study was to analyse the frequency of genotypes and alleles of single-nucleotide polymorphism (SNP)-G2677T/A (rs2032582) of MDR1 gene and to investigate the significance this genetic variation exerts on drug-resistant epilepsy (DRE) in the Polish adult population. The study comprised 340 patients treated for DRE and 240 patients treated for drug-responsive epilepsy. Three hundred and sixty disease-free individuals were used as controls. Genomic DNA was isolated, and the SNP G2677T/A of MDR1 was determined by High-Resolution Melter technique...
June 12, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28605630/cognitive-outcome-after-epilepsy-surgery-in-children-a-controlled-longitudinal-study
#11
Valentina Sibilia, Carmen Barba, Tiziana Metitieri, Giovanni Michelini, Flavio Giordano, Lorenzo Genitori, Renzo Guerrini
OBJECTIVE: To analyze the determinants of cognitive outcome two years after surgery for drug-resistant epilepsy in a cohort of 31 children when compared to a control group of 14 surgical candidates who had yet to undergo surgery two years after the first neuropsychological assessment. METHODS: Controlled longitudinal study including three evaluations of IQ (Intelligence Quotient) scores or GDQ (General Developmental Quotient) for each group depending on the patient's age: prior to surgery (T0), one year (T1) and two years (T2) after surgery for the surgical group; baseline (T0) and one year (T1) and 2years (T2) after the first evaluation for the control-group...
June 9, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28602600/influence-of-the-dual-combination-of-silymarin-and-epigallocatechin-gallate-natural-dietary-flavonoids-on-the-pharmacokinetics-of-oxcarbazepine-in-rats
#12
Ana Ferreira, Márcio Rodrigues, Alexandre Marques, Amílcar Falcão, Gilberto Alves
Considering the potential of flavonoids in reversing the P-glycoprotein (P-gp)-mediated multidrug resistance, this work aimed to assess the combined effects of silymarin and (-)-epigallocatechin gallate (EPG) on the pharmacokinetics of the P-gp substrates oxcarbazepine (OXC) and licarbazepine (LIC). Rats were pre-treated intraperitoneally with silymarin (25 mg/kg), EPG (25 mg/kg), silymarin/EPG (12.5/12.5 mg/kg; 6.25/18.75 mg/kg; 18.75/6.25 mg/kg) or verapamil (25 mg/kg, reference P-gp inhibitor) before the intraperitoneal administration of OXC (50 mg/kg)...
June 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28600632/dynamic-complexity-measures-and-entropy-paths-for-modelling-and-comparison-of-evolution-of-patients-with-drug-resistant-epileptic-encephalopathy-syndromes-drees
#13
Ricardo Zavala-Yoe, Ricardo A Ramirez-Mendoza
Epileptic encephalopathies (EE) is a term coined by the International League Against Epilepsy (ILAE) to refer to a group of epilepsies in which the ictal and interictal abnormalities may contribute to progressive cerebral dysfunction. Among them, two affect mainly children and are very difficult to deal with, Doose and Lennox-Gastaut syndromes, (DS and LGS, respectively). So far (Zavala-Yoe et al., J Integr Neurosci 15(2):205-223, 2015a and works of ours there), quantitative analysis of single case studies of EE have been performed...
June 9, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28591485/medical-management-and-antiepileptic-drugs-in-hypothalamic-hamartoma
#14
J Helen Cross, Helen Spoudeas
Hypothalamic hamartoma may present with epilepsy, specifically gelastic or dacrystic seizures, or endocrine dysfunction, commonly precocious puberty. The epilepsy in many patients is drug resistant, and has a high association with progressive cognitive, learning and behavioral difficulty. Medical treatment of seizures remains problematic, with many resistant to drug treatment. Surgical resection, or disconnection of the hamartoma provides the optimal chance of seizure control but with a relatively high risk of endocrine dysfunction, the result of interference with the hypothalamic-pituitary axis in many...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28591484/safety-and-efficacy-of-gamma-knife-radiosurgery-in-hypothalamic-hamartomas-with-severe-epilepsies-a-prospective-trial-in-48-patients-and-review-of-the-literature
#15
Jean Régis, Medhi Lagmari, Romain Carron, Motohiro Hayashi, Aileen McGonigal, Géraldine Daquin, Nathalie Villeneuve, Virginie Laguitton, Fabrice Bartolomei, Patrick Chauvel
Epilepsies associated with hypothalamic hamartomas (HHs) are frequently drug resistant with severe psychiatric and cognitive comorbidities. We performed a prospective trial to evaluate the safety and efficacy of Gamma Knife radiosurgery (GKS). Between October 1999 and October 2007, a total of 57 patients were investigated, included and treated by GKS in Timone University Hospital. Preoperative workup and 3-year postoperative evaluation consisted of seizure diary, neuropsychological, psychiatric, endocrinologic, visual field, and visual acuity examinations...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28591476/clinical-features-and-evolution-of-the-gelastic-seizures-hypothalamic-hamartoma-syndrome
#16
Salvatore Striano, Pasquale Striano
Gelastic seizures, usually with onset in early infancy, are the hallmark manifestation of hypothalamic hamartoma. This seizure type is directly generated by hamartoma itself, intrinsically epileptogenic because of its anatomofunctional organization. Other types of seizures, focal or generalized, may appear during the evolution, probably resulting from mechanisms of secondary epileptogenesis. Nevertheless, the clinical expression and the severity of the syndrome, ranging from a focal drug-resistant epilepsy to a catastrophic generalized encephalopathy with severe cognitive and behavioral impairments, depends on the size and the site of attachment of the hamartoma...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28589569/identification-of-novel-bcl11a-variants-in-patients-with-epileptic-encephalopathy-expanding-the-phenotypic-spectrum
#17
Michiko Yoshida, Mitsuko Nakashima, Tohru Okanishi, Sotaro Kanai, Ayataka Fujimoto, Kazuya Itomi, Masafumi Morimoto, Hirotomo Saitsu, Mitsuhiro Kato, Naomichi Matsumoto, Tomohiro Chiyonobu
BCL11A encodes a zinc finger protein that is highly expressed in hematopoietic tissues and the brain, and that is known to function as a transcriptional repressor of fetal hemoglobin (HbF). Recently, de novo variants in BCL11A have been reported in individuals with intellectual disability syndrome without epilepsy. In this study, we performed whole-exome sequencing of 302 patients with epileptic encephalopathies (EEs), and identified two novel BCL11A variants, c.577delC (p.His193Metfs*3) and c.2351A>C (p...
June 6, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28587680/in-vitro-antineoplastic-effects-of-brivaracetam-and-lacosamide-on-human-glioma-cells
#18
Ambra Rizzo, Sara Donzelli, Vita Girgenti, Andrea Sacconi, Chiara Vasco, Andrea Salmaggi, Giovanni Blandino, Marta Maschio, Emilio Ciusani
BACKGROUND: Epilepsy is a frequent symptom in patients with glioma. Although treatment with antiepileptic drugs is generally effective in controlling seizures, drug-resistant patients are not uncommon. Multidrug resistance proteins (MRPs) and P-gp are over-represented in brain tissue of patients with drug-resistant epilepsy, suggesting their involvement in the clearance of antiepileptic medications. In addition to their anticonvulsant action, some drugs have been documented for cytotoxic effects...
June 6, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28568478/behavioural-changes-in-patients-with-intellectual-disability-treated-with-perampanel
#19
E Andres, F Kerling, H Hamer, B Kasper, M Winterholler
OBJECTIVES: The aim of this cross-sectional retrospective study was to assess the tolerability and efficacy of perampanel in patients with drug-resistant epilepsy who also suffered from intellectual disability (ID). PATIENTS AND METHODS: We used an industry-independent, non-interventional retrospective evaluation based on standardized, daily seizure records. Twenty-seven patients with ID and drug-resistant epilepsy were started on perampanel between September 2012 and November 2015 after a 3-month observation period without perampanel treatment...
June 1, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28560798/vns-and-pregnancy-a-multicentric-experience-of-four-cases
#20
X Rodríguez-Osorio, F J López-González, Í Garamendi, J Rumià, A Matute, Á Prieto-González, M Carreño
BACKGROUND: Vagus nerve stimulation system (VNS) has been employed worldwide as adjunctive therapy in drug-resistant epileptic patients. Only nine previous pregnancies with six-positive outcomes have been reported in women with epilepsy treated with VNS since 1998. AIMS OF THE STUDY: To communicate the experience of pregnancies in women treated with VNS in our country. METHODS: Clinical data of four female patients treated with VNS during pregnancy and delivery in five gestations is described...
May 31, 2017: Acta Neurologica Scandinavica
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