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https://www.readbyqxmd.com/read/28609345/histopathologic-findings-of-cutaneous-hyperpigmentation-in-addison-disease-and-immunostain-of-the-melanocytic-population
#1
Angel Fernandez-Flores, David S Cassarino
The histopathological features of cutaneous hyperpigmentation in Addison disease have very occasionally been reported, and they include acanthosis, hyperkeratosis, focal parakeratosis, spongiosis, superficial perivascular lymphocytic infiltrate, basal melanin hyperpigmentation, and superficial dermal melanophages. We present a study on 2 biopsies from the arm and the thigh in a 77-year-old woman with a long clinical history of Addison disease as well as senile purpura and alopecia of female pattern. The patient presented diffuse hyperpigmentation of the skin, more pronounced on her face, and left upper forehead...
May 31, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28560214/clinical-and-histopathological-findings-of-frontal-fibrosing-alopecia-associated-lichen-planus-pigmentosus
#2
Ricardo Romiti, Camila Fátima Biancardi Gavioli, Alessandra Anzai, Andréia Munck, Carolina Oliveira Costa Fechine, Neusa Y S Valente
BACKGROUND: Frontal fibrosing alopecia (FFA) is a primary lymphocytic scarring alopecia occurring mainly in postmenopausal women. A range of facial lesions have been described in FFA, such as lichen planus (LP) pigmentosus, red dots, facial papules, and perifollicular and diffuse erythema. These lesions can be the first sign of FFA. LP pigmentosus is a rare variant of LP. The first description of LP pigmentosus associated with FFA (in 2012) reported 22 cases of LP pigmentosus among 44 cases of FFA affecting South African patients...
May 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28515994/in-vivo-reflectance-confocal-microscopy-a-useful-non-invasive-tool-to-assess-the-response-to-isolated-limb-perfusion-for-superficial-pigmented-melanoma-in-transit-metastatic-disease-report-of-a-case
#3
Rastine Merat, Wolf-Henning Boehncke, Gürkan Kaya
Complete response can be difficult to assess after isolated limb perfusion (ILP) for metastatic in-transit melanoma, especially when numerous and unresectable post-necrotic persisting pigmented lesions occur. These residual lesions are mainly seen in the more superficial and pigmented types of metastatic disease and correspond to the residual melanophage granuloma that persists after tumor tissues undergo complete necrosis. Reflectance confocal microscopy (RCM) is a non-invasive technique that allows the exploration of the superficial dermis...
April 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28403076/diffuse-melanosis-cutis-related-to-dermal-micrometastases-as-the-first-clinical-symptom-of-distant-metastatic-malignant-melanoma-case-report
#4
Joanna Maj, Alina Jankowska-Konsur, Joanna Gruber, Zdzisław Woźniak, Piotr Nockowski, Anita Hryncewicz-Gwóźdź
RATIONALE: Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications. PATIENT CONCERNS: A 72-year old Caucasian man was admitted to the Department of Dermatology with DMC for 4 months and the history of two melanomas treated surgically 30 years and 9 months before present hospitalization...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28348944/tumoral-melanosis-associated-with-pembrolizumab-treated-metastatic-melanoma
#5
Omar Bari, Philip R Cohen
Tumoral melanosis is a form of completely regressed melanoma that usually presents as darkly pigmented lesions suspicious for malignant melanoma. Histology reveals dense dermal and subcutaneous infiltration of melanophages. Pembrolizumab is an antibody directed against programmed death receptor-1 (PD1) and is frontline treatment for advanced melanoma. An 81-year-old man with metastatic melanoma treated with pembrolizumab who developed tumoral melanosis at previous sites of metastases is described. The PubMed database was searched with the key words: antibody, immunotherapy, melanoma, melanosis, metastasis, pembrolizumab, and tumoral...
February 13, 2017: Curēus
https://www.readbyqxmd.com/read/28346126/agreement-between-cytology-and-histopathology-for-regional-lymph-node-metastasis-in-dogs-with-melanocytic-neoplasms
#6
Janet A Grimes, Brad M Matz, Pete W Christopherson, Jey W Koehler, Kelsey K Cappelle, Katelyn C Hlusko, Annette Smith
Melanocytic neoplasms are common in dogs and frequently occur within the oral cavity or in haired skin. The behavior of melanocytic neoplasms is variable and depends on tumor location, size, and histopathologic features. This study compared cytopathology and histopathology of 32 lymph nodes from 27 dogs diagnosed with melanocytic neoplasms. Agreement between the original cytology report, cytology slide review, original histopathology report, and histopathology slide review was determined for each lymph node...
July 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28300883/coexistence-of-nail-lichen-planus-and-lichen-planus-pigmentosus
#7
Luciana Rodino Lemes, Renata Brandão Villa Verde, Sandra Maria Barbosa Durães, Adolpho de Alencar Araripe, Luciana Pantaleão
We describe a fifty-six-year old, Afro-descendent female patient showing dystrophy of her twenty nails and hyperchromic, asymptomatic macule on her face. Histopathological examination of the macule showed vacuolization of the basal layer, melanophages in the superficial dermis and lymphoplasmocytic inflammatory infiltrate. Nail biopsy revealed orthokeratotic hyperkeratosis and lichenoid inflammatory infiltrate. Lichen planus pigmentosus is an uncommon variety of lichen planus. It is characterized by typical hyperpigmented macules on the face and neck...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28296736/dermoscopic-features-of-livedoid-vasculopathy
#8
Stephen Chu-Sung Hu, Gwo-Shing Chen, Chi-Ling Lin, Yang-Chun Cheng, Yung-Song Lin
Livedoid vasculopathy (atrophie blanche) is a form of thrombotic vasculopathy. It is characterized by small ulcers that become crusted, and heal after several months to produce white atrophic scars. The most commonly affected sites are the lower legs, in particular the dorsum of the feet and ankles. To date, the dermoscopic features of livedoid vasculopathy have not been clearly described in the literature. In this observational study, we sought to evaluate the dermoscopic patterns of livedoid vasculopathy and determine whether the dermoscopic features are associated with certain histopathological characteristics...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28248716/intraepithelial-melanoma-in-the-stomach-after-treatment-with-immune-checkpoint-blockade-therapy
#9
Elina Shustef, Carlos A Torres-Cabala, Jonathan L Curry, Michael T Tetzlaff, Priyadharsini Nagarajan, Doina Ivan, Victor G Prieto, Phyu P Aung
Melanoma is the most common tumor to metastasize to the gastrointestinal tract, commonly affecting the small intestine, colon, and anorectum. Primary mucosal melanoma can arise in any gastrointestinal site, most frequently affecting anorectal mucosa. Melanoma involving the gastric mucosa, specifically, is exceedingly rare and carries a poor prognosis with a median survival of 5 months. The presence of atypical melanocytes exclusively within gastric epithelium has not been previously described. We report a case of a 52-year-old man with widespread BRAFV600E mutant metastatic melanoma who was referred to our institution for immune checkpoint antibody-blockade therapy...
August 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28240749/regression-in-primary-cutaneous-melanoma-etiopathogenesis-and-clinical-significance
#10
Phyu P Aung, Priyadharsini Nagarajan, Victor G Prieto
Though not required currently for staging, regression is a histopathologic parameter typically reported upon diagnosis of an invasive primary cutaneous melanoma. The studies examining the prognostic significance of regression in patient outcome have yielded controversial findings; likely because the definition and assessment of regression have not been consistent, in addition to subjectivity of pathologists' interpretation. Regression is histologically characterized by variable decrease in the number of melanoma cells accompanied by the presence of a host response consisting of dermal fibrosis, inflammatory infiltrate, melanophages, ectatic blood vessels, epidermal attenuation, and/or apoptosis of keratinocytes or melanocytes; the relative extent of these features depends on the stage of the regression...
February 27, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28224168/differential-clinicopathological-features-in-spontaneous-regression-of-melanomas-and-melanocytic-naevi
#11
José M Martín, Isabel Pinazo, Esperanza Jordá, Carlos Monteagudo
The aim of this study was to determine the clinical, histological and/or immunohistochemical features that enable differential diagnosis of regression of melanocytic naevi from regression of melanomas. All melanocytic neoplasms with histologically-confirmed regression diagnosed in our hospital between 2002 and 2009 were reviewed retrospectively. Lamellar and delicate fibrosis were associated with melanocytic naevi (p < 0.0001 and p = 0.021, respectively). Compact fibrosis, high vessel density and higher number of granzyme B+ lymphocytes were associated with malignant melanoma (p = 0...
February 22, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28132411/a-case-report-of-disappearing-pigmented-skin-lesions-associated-with-pembrolizumab-treatment-for-metastatic-melanoma
#12
Z J Wolner, A A Marghoob, M P Pulitzer, M A Postow, M A Marchetti
Pembrolizumab is an immune checkpoint inhibitor that targets the programmed cell death (PD)-1 receptor. Common cutaneous adverse side effects of PD-1 inhibitors include maculopapular rash, pruritus, vitiligo, and lichenoid skin and mucosal reactions. Here, we describe a man in his sixties with metastatic melanoma treated with pembrolizumab who subsequently developed fading or disappearance of pigmented skin lesions, lightening of the skin, and poliosis of the eyebrows, eyelashes, and scalp and body hair. Compared to baseline high-resolution three-dimensional total body photography, we observed fading or disappearing of solar lentigines, seborrheic keratoses, and melanocytic naevi, suggesting that PD-1 inhibitors may affect the evolution of these benign skin lesions...
January 28, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28026045/differentiating-regressed-melanoma-from-regressed-lichenoid-keratosis
#13
Aegean H Chan, Kenneth J Shulman, Bonnie A Lee
BACKGROUND: Distinguishing regressed lichen planus-like keratosis (LPLK) from regressed melanoma can be difficult on histopathologic examination, potentially resulting in mismanagement of patients. OBJECTIVE: We aimed to identify histopathologic features by which regressed melanoma can be differentiated from regressed LPLK. METHODS: Twenty actively inflamed LPLK, 12 LPLK with regression and 15 melanomas with regression were compared and evaluated by hematoxylin and eosin staining as well as Melan-A, microphthalmia transcription factor (MiTF) and cytokeratin (AE1/AE3) immunostaining...
April 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27943433/melanin-granules-melanophages-and-a-fully-melanized-epidermis-are-common-traits-of-odontocete-and-mysticete-cetaceans
#14
Blanca Morales-Guerrero, Cecilia Barragán-Vargas, German R Silva-Rosales, Christian D Ortega-Ortiz, Diane Gendron, Laura M Martinez-Levasseur, Karina Acevedo-Whitehouse
BACKGROUND: The cellular mechanisms used to counteract or limit damage caused by exposure of marine vertebrates to solar ultraviolet (UV) radiation are poorly understood. Cetaceans are vulnerable because they lack protective skin appendages and are obliged to surface continuously to breathe, thus being exposed repeatedly to UV light. Although molecular mechanisms of photoprotection of cetaceans have been studied, there is limited knowledge about their epidermal structure and photoprotective effectors...
December 11, 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27867740/regressing-basal-cell-carcinoma-masquerading-as-benign-lichenoid-keratosis
#15
Aleksandra Kulberg, Wolfgang Weyers
BACKGROUND: Benign lichenoid keratosis (BLK, LPLK) is often misdiagnosed clinically as superficial basal-cell carcinoma (BCC), especially when occurring on the trunk. However, BCCs undergoing regression may be associated with a lichenoid interface dermatitis that may be misinterpreted as BLK in histopathologic sections. METHODS: In order to assess the frequency of remnants of BCC in lesions interpreted as BLK, we performed step sections on 100 lesions from the trunk of male patients that had been diagnosed as BLK...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27688435/lichen-planus-pigmentosus-the-controversial-consensus
#16
REVIEW
Aparajita Ghosh, Arijit Coondoo
A pigmented variant of lichen planus (LP) was first reported from India in 1974 by Bhutani et al. who coined the term LP pigmentosus (LPP) to give a descriptive nomenclature to it. LP has a number of variants, one of which is LPP. This disease has also later been reported from the Middle East, Latin America, Korea, and Japan, especially in people with darker skin. It has an insidious onset. Initially, small, black or brown macules appear on sun-exposed areas. They later merge to form large hyperpigmented patches...
September 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27456492/complete-regression-of-primary-cutaneous-malignant-melanoma-associated-with-distant-lymph-node-metastasis-a-teaching-case-mimicking-blue-nevus
#17
Sohsuke Yamada, Aya Nawata, Manabu Yoshioka, Tsubasa Hiraki, Michiyo Higashi, Kazuhito Hatanaka, Akihide Tanimoto
BACKGROUND: Malignant melanoma (MM) tends to be spontaneously regressed, however, complete regression of primary cutaneous MM is an extremely rare phenomenon. Our aim is to be aware that pathologists and/or dermatologists can readily misinterpret it as the other benign or malignant lesions. CASE PRESENTATION: A gradually growing and verrucous hypopigmented macule had been noticed in the right sole of a 65-year-old Japanese male since 2 years before, and it turned to be a solitary bluish to black patch with surrounding depigmentation and was recently decreased in size...
July 26, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27389718/idiopathic-eruptive-macular-pigmentation-in-a-child-with-citrin-deficiency
#18
Chu-Li Fu, Yun-Feng Hu, Yuan-Zong Song
Idiopathic eruptive macular pigmentation (IEMP) is a rare dermatological disorder with generally unclear etiology and pathogenesis. A 5½-year-old girl was referred to hospital with a 10 month history of brown skin rashes. In early infancy, citrin deficiency had been diagnosed with the SLC25A13 genotype c.851_854del4/c.998G > A, but all clinical and laboratory abnormalities recovered following the introduction of a lactose-free and medium-chain triglyceride-enriched formula. Physical examination at referral indicated symmetric, multiple and non-scaly brown macules on the neck, trunk, buttocks and proximal parts of the extremities...
September 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27346606/a-pilot-study-for-triple-combination-therapy-with-a-low-fluence-1064%C3%A2-nm-q-switched-nd-yag-laser-hydroquinone-cream-and-oral-tranexamic-acid-for-recalcitrant-riehl-s-melanosis
#19
Hyuck Hoon Kwon, Jungyoon Ohn, Dae Hun Suh, Hae Young Park, Sun Chul Choi, Jae Yoon Jung, In Ho Kwon, Gyeong-Hun Park
BACKGROUND: Riehl's melanosis presents as a diffuse gray-brown to black hyperpigmentation around face. The treatment of this disease is challenging and quite limited despite patients' excessive psychological stresses. OBJECTIVE: In this prospective pilot study, we evaluated the efficacy and safety for a novel combination therapy based on low-fluence Q-switched 1064 nm Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's melanosis...
March 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27267189/amitriptyline-induced-cutaneous-hyperpigmentation-case-report-and-review-of-psychotropic-drug-associated-mucocutaneous-hyperpigmentation
#20
REVIEW
Dawn Zhang Eichenfield, Philip Cohen
BACKGROUND: Several drugs can be associated with hyperpigmentation of mucosa or skin. They include antibiotic, antimalarial, antineoplastic, and psychotropic medications. PURPOSE: To describe a 42-year-old woman with amitriptyline-associated photo-distributed hyperpigmentation and to review psychotropic drug-induced hyperpigmentation of the skin. MATERIALS AND METHODS: The features of a woman with amitriptyline-induced hyperpigmentation are presented...
February 17, 2016: Dermatology Online Journal
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