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https://www.readbyqxmd.com/read/27867740/regressing-basal-cell-carcinoma-masquerading-as-benign-lichenoid-keratosis
#1
Aleksandra Kulberg, Wolfgang Weyers
BACKGROUND: Benign lichenoid keratosis (BLK, LPLK) is often misdiagnosed clinically as superficial basal-cell carcinoma (BCC), especially when occurring on the trunk. However, BCCs undergoing regression may be associated with a lichenoid interface dermatitis that may be misinterpreted as BLK in histopathologic sections. METHODS: In order to assess the frequency of remnants of BCC in lesions interpreted as BLK, we performed step sections on 100 lesions from the trunk of male patients that had been diagnosed as BLK...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27688435/lichen-planus-pigmentosus-the-controversial-consensus
#2
REVIEW
Aparajita Ghosh, Arijit Coondoo
A pigmented variant of lichen planus (LP) was first reported from India in 1974 by Bhutani et al. who coined the term LP pigmentosus (LPP) to give a descriptive nomenclature to it. LP has a number of variants, one of which is LPP. This disease has also later been reported from the Middle East, Latin America, Korea, and Japan, especially in people with darker skin. It has an insidious onset. Initially, small, black or brown macules appear on sun-exposed areas. They later merge to form large hyperpigmented patches...
September 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27456492/complete-regression-of-primary-cutaneous-malignant-melanoma-associated-with-distant-lymph-node-metastasis-a-teaching-case-mimicking-blue-nevus
#3
Sohsuke Yamada, Aya Nawata, Manabu Yoshioka, Tsubasa Hiraki, Michiyo Higashi, Kazuhito Hatanaka, Akihide Tanimoto
BACKGROUND: Malignant melanoma (MM) tends to be spontaneously regressed, however, complete regression of primary cutaneous MM is an extremely rare phenomenon. Our aim is to be aware that pathologists and/or dermatologists can readily misinterpret it as the other benign or malignant lesions. CASE PRESENTATION: A gradually growing and verrucous hypopigmented macule had been noticed in the right sole of a 65-year-old Japanese male since 2 years before, and it turned to be a solitary bluish to black patch with surrounding depigmentation and was recently decreased in size...
2016: BMC Research Notes
https://www.readbyqxmd.com/read/27389718/idiopathic-eruptive-macular-pigmentation-in-a-child-with-citrin-deficiency
#4
Chu-Li Fu, Yun-Feng Hu, Yuan-Zong Song
Idiopathic eruptive macular pigmentation (IEMP) is a rare dermatological disorder with generally unclear etiology and pathogenesis. A 5½-year-old girl was referred to hospital with a 10 month history of brown skin rashes. In early infancy, citrin deficiency had been diagnosed with the SLC25A13 genotype c.851_854del4/c.998G > A, but all clinical and laboratory abnormalities recovered following the introduction of a lactose-free and medium-chain triglyceride-enriched formula. Physical examination at referral indicated symmetric, multiple and non-scaly brown macules on the neck, trunk, buttocks and proximal parts of the extremities...
September 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27346606/a-pilot-study-for-triple-combination-therapy-with-a-low-fluence-1064%C3%A2-nm-q-switched-nd-yag-laser-hydroquinone-cream-and-oral-tranexamic-acid-for-recalcitrant-riehl-s-melanosis
#5
Hyuck Hoon Kwon, Jungyoon Ohn, Dae Hun Suh, Hae Young Park, Sun Chul Choi, Jae Yoon Jung, In Ho Kwon, Gyeong-Hun Park
BACKGROUND: Riehl's melanosis presents as a diffuse gray-brown to black hyperpigmentation around face. The treatment of this disease is challenging and quite limited despite patients' excessive psychological stresses. OBJECTIVE: In this prospective pilot study, we evaluated the efficacy and safety for a novel combination therapy based on low-fluence Q-switched 1064 nm Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's melanosis...
June 27, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27267189/amitriptyline-induced-cutaneous-hyperpigmentation-case-report-and-review-of-psychotropic-drug-associated-mucocutaneous-hyperpigmentation
#6
Dawn Zhang Eichenfield, Philip Cohen
BACKGROUND: Several drugs can be associated with hyperpigmentation of mucosa or skin. They include antibiotic, antimalarial, antineoplastic, and psychotropic medications. PURPOSE: To describe a 42-year-old woman with amitriptyline-associated photo-distributed hyperpigmentation and to review psychotropic drug-induced hyperpigmentation of the skin. MATERIALS AND METHODS: The features of a woman with amitriptyline-induced hyperpigmentation are presented...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27222769/chronology-of-lichen-planus-like-keratosis-features-by-dermoscopy-a-summary-of-17-cases
#7
REVIEW
Soko Watanabe, Mizuki Sawada, Itaru Dekio, Sumiko Ishizaki, Mariko Fujibayashi, Masaru Tanaka
Dermoscopic findings for 17 cases of lichen planus-like keratosis (LPLK) were chronologically evaluated. Three males and 14 females were included in the study and the ages ranged from 43 to 85 years (median 65 years). Three cases were diagnosed based on stereotypical dermoscopic findings, while the other 14 cases were histopathologically diagnosed as LPLK. Dermoscopy photographs were divided into four groups depending on the number of days (D) from the initial visit: 1) D = 0 (initial visit or biopsy day); 2) D = 61 to 180; 3) D = 181 to 270; 4) D = 271 to 360...
April 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27171521/unilateral-conjunctival-in-situ-squamous-carcinoma-with-bilateral-conjunctival-chlorpromazine-induced-secondary-melanosis-masquerading-as-in-situ-and-invasive-melanoma
#8
Katharine S Sears, Ian G Rennie, Hardeep Singh Mudhar
PURPOSE: To describe the clinical and histopathological features of a 61-year-old male with a history of eczema, asthma and schizophrenia on long-term chlorpromazine medication, who developed a unilateral limbal tumour in association with bilateral melanosis. PROCEDURES: The patient was referred for a routine cataract assessment, and an incidental pink gelatinous limbal lesion was detected on the left side, associated with bilateral speckled brown conjunctival pigmentation...
June 2015: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27149137/meyerson-phenomenon-as-a-component-of-melanoma-in-situ
#9
Engin Sezer, Emel Özturk Durmaz, Emel Çetin, Sedef Şahin
Meyerson phenomenon (MP) is characterized by a symmetrical area of erythema and scales encircling a central lesion, which is most commonly a banal melanocytic nevus. Herein, we describe an unusual case with MP representing an eczematized response to a melanoma in situ and review the literature covering this entity. A 56-year-old man presented with a 6-month history of a pruritic, pigmented lesion on the trunk. The patient had no other significant medical history and no notable family history of similar lesions...
April 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27146778/a-clinicopathologic-study-of-malignant-melanoma-based-on-cytomorphology
#10
K Radhika, A K Prayaga, C Sundaram
CONTEXT: Melanoma accounts for 1-3% of all malignancies. It is usually diagnosed as metastasis in the draining lymph nodes, that is inguinal lymph node. Due to paucity of cytological studies on melanoma in India, the present study was undertaken. AIM: To study the cytomorphology of malignant melanoma and to correlate the cytological diagnosis with histopathology and clinical details. SETTINGS AND DESIGN: Sixteen cytomorphological features were studied and analysed from the cases diagnosed as melanoma on cytology with histopathological correlation...
January 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/26978003/clinicopathologic-analysis-of-stable-and-unstable-vitiligo-a-study-of-66-cases
#11
Amit Kumar Yadav, Priyanka Singh, Niti Khunger
Vitiligo is an acquired skin disorder characterized by milky-white macules and absence of functioning melanocytes. The cornerstone of its management is the correct categorization of a case into its 2 broad types-stable and unstable vitiligo. This distinction is at present based mainly on clinical criteria because the histopathological features are not fully established. This study was thus undertaken to examine histopathological features of vitiligo and to come up with a reliable and systematic approach toward this diagnostic challenge...
August 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26892480/three-cases-of-pigmented-cosmetic-dermatitis-like-eruptions-associated-with-primary-sj%C3%A3-gren-s-syndrome-or-anti-ssa-antibody
#12
Naoko Takeo, Takashi Sakai, Tomoko Saito-Shono, Kazushi Ishikawa, Yutaka Hatano, Kazumoto Katagiri, Yoshihiro Takahashi, Kenji Kawano, Kenichi Kimoto, Toshiaki Kubota, Nobuoki Eshima, Hiroto Kojima, Sakuhei Fujiwara
Pigmented cosmetic dermatitis-like (Riehl's melanosis-like) pigmentation was reported in three of 27 patients with primary Sjögren's syndrome. But case reports of such eruptions are rare. We describe three cases of such eruptions associated with primary Sjögren's syndrome or anti-SSA antibody and possible associations with specific types of human leukocyte antigen (HLA) and infiltrating lymphocytes. These middle-aged Japanese women had reticular facial pigmentation and histopathological examination revealed interface dermatitis, melanophages, and dense lymphocytic infiltration around hair follicles and sweat ducts...
August 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/26403597/in-vivo-confocal-microscopic-substrate-of-grey-colour-in-melanosis
#13
E Cinotti, C Couzan, J L Perrot, C Habougit, B Labeille, F Cambazard, E Moscarella, A Kyrgidis, G Argenziano, G Pellacani, C Longo
BACKGROUND: Melanosis is the most common cause of mucosal pigmentation and can be clinically difficult to differentiate from early melanoma (MM). Dermoscopy can help in the distinction between melanosis and MM, but in some instances, melanoses may exhibit overlapping features with MM such as the presence of grey colour. OBJECTIVE: We sought to evaluate whether reflectance confocal microscopy (RCM) can help to better understand the dermoscopic features of melanoses in order to assist clinicians in their diagnosis...
December 2015: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/26381028/braf-inhibitor-induced-antitumoral-granulomatous-dermatitis-eruption-in-advanced-melanoma
#14
Maria C Garrido, Carlota Gutierrez, Erica Riveiro-Falkenbach, Pablo Ortiz, Jose L Rodriguez-Peralto
Recent advances in targeting BRAF mutations, which occur in roughly 50% of the melanomas, have improved response rates and overall survival in patients with advanced disease. With the increasingly extensive use of the drug, new, nonpreventable, cutaneous and noncutaneous toxicities keep arising as infrequent adverse effects. We report a 55-year-old man with a history of metastatic melanoma treated with the dabrafenib who presented, 10 months after the initiation of the treatment, with erythematous, slightly squamous, round plaques on his upper trunk and on his left upper arm...
October 2015: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26359338/suspected-vitreous-seeding-of-uveal-melanoma-relevance-of-diagnostic-vitrectomy
#15
Claudia H D Metz, Norbert Bornfeld, Klaus A Metz, Mete Gök
AIM: To review all cases of suspected vitreous seeding of treated or untreated uveal melanoma at our clinic and to compare clinical, cytological and histological findings with patients' survival. METHODS: Retrospective non-randomised study of 23 patients with consecutive uveal melanoma who underwent diagnostic vitrectomy in our clinic between January 2000 and November 2013. Reason for vitrectomy was suspected dissemination of tumour cells inside the eye. Treated as well as treatment-naïve primary uveal melanomas were included in this study...
May 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/26269701/abrupt-intralesional-color-change-on-dermoscopy-as-a-new-indicator-of-early-superficial-spreading-melanoma-in-a-japanese-woman
#16
Anna Sadayasu, Masaru Tanaka, Yoshifumi Maumi, Eriko Ikeda, Mizuki Sawada, Sumiko Ishizaki, Yoshiyuki Murakami, Mariko Fujibayashi
Diagnosis of superficial spreading melanoma in the early stage is often difficult, even with dermoscopy. We report the case of a 37-year-old Japanese woman with superficial spreading melanoma in her left buttock. The lesion developed 20 years before becoming visible and gradually enlarged over the past few years without any symptoms. Physical examination showed a well-demarcated dark-brown macule 10 mm in diameter. Dermoscopy demonstrated a central dark area with a blue-grey structureless area, a milky-red area with irregular blue-grey dots or globules suggestive of regression structures, and multifocal black pigmentation with whitish scaly areas...
May 2015: Case Reports in Dermatology
https://www.readbyqxmd.com/read/26260852/fibroelastolytic-papulosis-histopathologic-confirmation-of-disease-spectrum-variants-in-a-single-case
#17
Andrew T Patterson, Knox J Beasley, Todd T Kobayashi
Fibroelastolytic papulosis is a rare, acquired fibroelastolytic disorder that presents clinically as white-to-yellow papules and plaques most commonly occurring on the neck of elderly patients. The term fibroelastolytic papulosis encompasses two closely related conditions previously described as pseudoxanthoma elasticum-like papillary dermal elastolysis (PDE) and white fibrous papulosis of the neck (WFPN). Here we present a case of a 78-year-old white female with a several-year history of numerous, asymptomatic 2-3 mm yellowish, non-follicular papules distributed symmetrically over the posterior neck, axillae, arm and antecubital fossae...
February 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/26256624/dermatopathology-effects-of-simulated-solar-particle-event-radiation-exposure-in-the-porcine-model
#18
Jenine K Sanzari, Eric S Diffenderfer, Sarah Hagan, Paul C Billings, Daila S Gridley, John T Seykora, Ann R Kennedy, Keith A Cengel
The space environment exposes astronauts to risks of acute and chronic exposure to ionizing radiation. Of particular concern is possible exposure to ionizing radiation from a solar particle event (SPE). During an SPE, magnetic disturbances in specific regions of the Sun result in the release of intense bursts of ionizing radiation, primarily consisting of protons that have a highly variable energy spectrum. Thus, SPE events can lead to significant total body radiation exposures to astronauts in space vehicles and especially while performing extravehicular activities...
July 2015: Life Sciences in Space Research
https://www.readbyqxmd.com/read/26225334/idiopathic-eruptive-macular-pigmentation-in-a-chinese-child
#19
Zha Wei-Feng, Xu Ai-E, Chen Jun-Fan
We present a case of a healthy 8-year-old boy who presented with disseminated asymptomatic brown macules on the face, neck, trunk, and proximal extremities for 3 months. Dermatologic examination revealed multiple, smooth, nonscaly, brown macules involving the face, neck, trunk, and proximal limbs. The Darier's sign was negative. Histopathologic study showed normal epidermis and basal membrane, and increasingly scattered melanophages in the papillary dermis. The final diagnosis was idiopathic eruptive macular pigmentation...
July 2015: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/26190239/melanocytic-nevi-excised-during-b-raf-proto-oncogene-braf-inhibitor-therapy-a-study-of-19-lesions-from-10-patients
#20
COMPARATIVE STUDY
Mark C Mochel, Marc R Hammond, Dennie T Frederick, Maria B Alora-Palli, Adriano Piris, Keith T Flaherty, Mai P Hoang
BACKGROUND: There are limited descriptions of histopathology and immune profiles of new or changing melanocytic nevi in the setting of B-Raf proto-oncogene (BRAF) inhibitor therapy. OBJECTIVE: We sought to identify their distinctive features. METHODS: Clinical charts and histologic review, neuroblastoma RAS viral (v-ras) oncogene homolog genotyping, and immunohistochemistry for HMB-45, BRAFV600E, phosphorylated extracellular signal-regulated kinase (pERK), phosphorylated protein kinase B, CD4, and CD8 were performed on 19 melanocytic nevi from 10 patients and 23 control nevi...
September 2015: Journal of the American Academy of Dermatology
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