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https://www.readbyqxmd.com/read/28300883/coexistence-of-nail-lichen-planus-and-lichen-planus-pigmentosus
#1
Luciana Rodino Lemes, Renata Brandão Villa Verde, Sandra Maria Barbosa Durães, Adolpho de Alencar Araripe, Luciana Pantaleão
We describe a fifty-six-year old, Afro-descendent female patient showing dystrophy of her twenty nails and hyperchromic, asymptomatic macule on her face. Histopathological examination of the macule showed vacuolization of the basal layer, melanophages in the superficial dermis and lymphoplasmocytic inflammatory infiltrate. Nail biopsy revealed orthokeratotic hyperkeratosis and lichenoid inflammatory infiltrate. Lichen planus pigmentosus is an uncommon variety of lichen planus. It is characterized by typical hyperpigmented macules on the face and neck...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28296736/dermoscopic-features-of-livedoid-vasculopathy
#2
Stephen Chu-Sung Hu, Gwo-Shing Chen, Chi-Ling Lin, Yang-Chun Cheng, Yung-Song Lin
Livedoid vasculopathy (atrophie blanche) is a form of thrombotic vasculopathy. It is characterized by small ulcers that become crusted, and heal after several months to produce white atrophic scars. The most commonly affected sites are the lower legs, in particular the dorsum of the feet and ankles. To date, the dermoscopic features of livedoid vasculopathy have not been clearly described in the literature. In this observational study, we sought to evaluate the dermoscopic patterns of livedoid vasculopathy and determine whether the dermoscopic features are associated with certain histopathological characteristics...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28248716/intraepithelial-melanoma-in-the-stomach-after-treatment-with-immune-checkpoint-blockade-therapy
#3
Elina Shustef, Carlos A Torres-Cabala, Jonathan L Curry, Michael T Tetzlaff, Priyadharsini Nagarajan, Doina Ivan, Victor G Prieto, Phyu P Aung
Melanoma is the most common tumor to metastasize to the gastrointestinal tract, commonly affecting the small intestine, colon, and anorectum. Primary mucosal melanoma can arise in any gastrointestinal site, most frequently affecting anorectal mucosa. Melanoma involving the gastric mucosa, specifically, is exceedingly rare and carries a poor prognosis with a median survival of 5 months. The presence of atypical melanocytes exclusively within gastric epithelium has not been previously described. We report a case of a 52-year-old man with widespread BRAFV600E mutant metastatic melanoma who was referred to our institution for immune checkpoint antibody-blockade therapy...
February 23, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28240749/regression-in-primary-cutaneous-melanoma-etiopathogenesis-and-clinical-significance
#4
Phyu P Aung, Priyadharsini Nagarajan, Victor G Prieto
Though not required currently for staging, regression is a histopathologic parameter typically reported upon diagnosis of an invasive primary cutaneous melanoma. The studies examining the prognostic significance of regression in patient outcome have yielded controversial findings; likely because the definition and assessment of regression have not been consistent, in addition to subjectivity of pathologists' interpretation. Regression is histologically characterized by variable decrease in the number of melanoma cells accompanied by the presence of a host response consisting of dermal fibrosis, inflammatory infiltrate, melanophages, ectatic blood vessels, epidermal attenuation, and/or apoptosis of keratinocytes or melanocytes; the relative extent of these features depends on the stage of the regression...
February 27, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28224168/differential-clinicopathological-features-in-spontaneous-regression-of-melanomas-and-melanocytic-naevi
#5
José M Martín, Isabel Pinazo, Esperanza Jordá, Carlos Monteagudo
The aim of this study was to determine the clinical, histological and/or immunohistochemical features that enable differential diagnosis of regression of melanocytic naevi from regression of melanomas. All melanocytic neoplasms with histologically-confirmed regression diagnosed in our hospital between 2002 and 2009 were reviewed retrospectively. Lamellar and delicate fibrosis were associated with melanocytic naevi (p < 0.0001 and p = 0.021, respectively). Compact fibrosis, high vessel density and higher number of granzyme B+ lymphocytes were associated with malignant melanoma (p = 0...
February 22, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28132411/a-case-report-of-disappearing-pigmented-skin-lesions-associated-with-pembrolizumab-treatment-for-metastatic-melanoma
#6
Z J Wolner, A A Marghoob, M P Pulitzer, M A Postow, M A Marchetti
Pembrolizumab is an immune checkpoint inhibitor that targets the programmed cell death (PD)-1 receptor. Common cutaneous adverse side effects of PD-1 inhibitors include maculopapular rash, pruritus, vitiligo, and lichenoid skin and mucosal reactions. Here, we describe a man in his sixties with metastatic melanoma treated with pembrolizumab who subsequently developed fading or disappearance of pigmented skin lesions, lightening of the skin, and poliosis of the eyebrows, eyelashes, and scalp and body hair. Compared to baseline high-resolution three-dimensional total body photography, we observed fading or disappearing of solar lentigines, seborrheic keratoses, and melanocytic naevi, suggesting that PD-1 inhibitors may affect the evolution of these benign skin lesions...
January 28, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28026045/differentiating-regressed-melanoma-from-regressed-lichenoid-keratosis
#7
Aegean H Chan, Kenneth J Shulman, Bonnie A Lee
BACKGROUND: Distinguishing regressed lichen planus-like keratosis (LPLK) from regressed melanoma can be difficult on histopathologic examination, potentially resulting in mismanagement of patients. OBJECTIVE: We aimed to identify histopathologic features by which regressed melanoma can be differentiated from regressed LPLK. METHODS: Twenty actively inflamed LPLK, 12 LPLK with regression and 15 melanomas with regression were compared and evaluated by hematoxylin and eosin staining as well as Melan-A, microphthalmia transcription factor (MiTF) and cytokeratin (AE1/AE3) immunostaining...
December 27, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27943433/melanin-granules-melanophages-and-a-fully-melanized-epidermis-are-common-traits-of-odontocete-and-mysticete-cetaceans
#8
Blanca Morales-Guerrero, Cecilia Barragán-Vargas, German R Silva-Rosales, Christian D Ortega-Ortiz, Diane Gendron, Laura M Martinez-Levasseur, Karina Acevedo-Whitehouse
BACKGROUND: The cellular mechanisms used to counteract or limit damage caused by exposure of marine vertebrates to solar ultraviolet (UV) radiation are poorly understood. Cetaceans are vulnerable because they lack protective skin appendages and are obliged to surface continuously to breathe, thus being exposed repeatedly to UV light. Although molecular mechanisms of photoprotection of cetaceans have been studied, there is limited knowledge about their epidermal structure and photoprotective effectors...
December 11, 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27867740/regressing-basal-cell-carcinoma-masquerading-as-benign-lichenoid-keratosis
#9
Aleksandra Kulberg, Wolfgang Weyers
BACKGROUND: Benign lichenoid keratosis (BLK, LPLK) is often misdiagnosed clinically as superficial basal-cell carcinoma (BCC), especially when occurring on the trunk. However, BCCs undergoing regression may be associated with a lichenoid interface dermatitis that may be misinterpreted as BLK in histopathologic sections. METHODS: In order to assess the frequency of remnants of BCC in lesions interpreted as BLK, we performed step sections on 100 lesions from the trunk of male patients that had been diagnosed as BLK...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27688435/lichen-planus-pigmentosus-the-controversial-consensus
#10
REVIEW
Aparajita Ghosh, Arijit Coondoo
A pigmented variant of lichen planus (LP) was first reported from India in 1974 by Bhutani et al. who coined the term LP pigmentosus (LPP) to give a descriptive nomenclature to it. LP has a number of variants, one of which is LPP. This disease has also later been reported from the Middle East, Latin America, Korea, and Japan, especially in people with darker skin. It has an insidious onset. Initially, small, black or brown macules appear on sun-exposed areas. They later merge to form large hyperpigmented patches...
September 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27456492/complete-regression-of-primary-cutaneous-malignant-melanoma-associated-with-distant-lymph-node-metastasis-a-teaching-case-mimicking-blue-nevus
#11
Sohsuke Yamada, Aya Nawata, Manabu Yoshioka, Tsubasa Hiraki, Michiyo Higashi, Kazuhito Hatanaka, Akihide Tanimoto
BACKGROUND: Malignant melanoma (MM) tends to be spontaneously regressed, however, complete regression of primary cutaneous MM is an extremely rare phenomenon. Our aim is to be aware that pathologists and/or dermatologists can readily misinterpret it as the other benign or malignant lesions. CASE PRESENTATION: A gradually growing and verrucous hypopigmented macule had been noticed in the right sole of a 65-year-old Japanese male since 2 years before, and it turned to be a solitary bluish to black patch with surrounding depigmentation and was recently decreased in size...
July 26, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27389718/idiopathic-eruptive-macular-pigmentation-in-a-child-with-citrin-deficiency
#12
Chu-Li Fu, Yun-Feng Hu, Yuan-Zong Song
Idiopathic eruptive macular pigmentation (IEMP) is a rare dermatological disorder with generally unclear etiology and pathogenesis. A 5½-year-old girl was referred to hospital with a 10 month history of brown skin rashes. In early infancy, citrin deficiency had been diagnosed with the SLC25A13 genotype c.851_854del4/c.998G > A, but all clinical and laboratory abnormalities recovered following the introduction of a lactose-free and medium-chain triglyceride-enriched formula. Physical examination at referral indicated symmetric, multiple and non-scaly brown macules on the neck, trunk, buttocks and proximal parts of the extremities...
September 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27346606/a-pilot-study-for-triple-combination-therapy-with-a-low-fluence-1064%C3%A2-nm-q-switched-nd-yag-laser-hydroquinone-cream-and-oral-tranexamic-acid-for-recalcitrant-riehl-s-melanosis
#13
Hyuck Hoon Kwon, Jungyoon Ohn, Dae Hun Suh, Hae Young Park, Sun Chul Choi, Jae Yoon Jung, In Ho Kwon, Gyeong-Hun Park
BACKGROUND: Riehl's melanosis presents as a diffuse gray-brown to black hyperpigmentation around face. The treatment of this disease is challenging and quite limited despite patients' excessive psychological stresses. OBJECTIVE: In this prospective pilot study, we evaluated the efficacy and safety for a novel combination therapy based on low-fluence Q-switched 1064 nm Nd:YAG laser, hydroquinone cream and oral tranexamic acid for recalcitrant Riehl's melanosis...
March 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27267189/amitriptyline-induced-cutaneous-hyperpigmentation-case-report-and-review-of-psychotropic-drug-associated-mucocutaneous-hyperpigmentation
#14
REVIEW
Dawn Zhang Eichenfield, Philip Cohen
BACKGROUND: Several drugs can be associated with hyperpigmentation of mucosa or skin. They include antibiotic, antimalarial, antineoplastic, and psychotropic medications. PURPOSE: To describe a 42-year-old woman with amitriptyline-associated photo-distributed hyperpigmentation and to review psychotropic drug-induced hyperpigmentation of the skin. MATERIALS AND METHODS: The features of a woman with amitriptyline-induced hyperpigmentation are presented...
February 17, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27222769/chronology-of-lichen-planus-like-keratosis-features-by-dermoscopy-a-summary-of-17-cases
#15
REVIEW
Soko Watanabe, Mizuki Sawada, Itaru Dekio, Sumiko Ishizaki, Mariko Fujibayashi, Masaru Tanaka
Dermoscopic findings for 17 cases of lichen planus-like keratosis (LPLK) were chronologically evaluated. Three males and 14 females were included in the study and the ages ranged from 43 to 85 years (median 65 years). Three cases were diagnosed based on stereotypical dermoscopic findings, while the other 14 cases were histopathologically diagnosed as LPLK. Dermoscopy photographs were divided into four groups depending on the number of days (D) from the initial visit: 1) D = 0 (initial visit or biopsy day); 2) D = 61 to 180; 3) D = 181 to 270; 4) D = 271 to 360...
April 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27171521/unilateral-conjunctival-in-situ-squamous-carcinoma-with-bilateral-conjunctival-chlorpromazine-induced-secondary-melanosis-masquerading-as-in-situ-and-invasive-melanoma
#16
Katharine S Sears, Ian G Rennie, Hardeep Singh Mudhar
PURPOSE: To describe the clinical and histopathological features of a 61-year-old male with a history of eczema, asthma and schizophrenia on long-term chlorpromazine medication, who developed a unilateral limbal tumour in association with bilateral melanosis. PROCEDURES: The patient was referred for a routine cataract assessment, and an incidental pink gelatinous limbal lesion was detected on the left side, associated with bilateral speckled brown conjunctival pigmentation...
June 2015: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27149137/meyerson-phenomenon-as-a-component-of-melanoma-in-situ
#17
Engin Sezer, Emel Özturk Durmaz, Emel Çetin, Sedef Şahin
Meyerson phenomenon (MP) is characterized by a symmetrical area of erythema and scales encircling a central lesion, which is most commonly a banal melanocytic nevus. Herein, we describe an unusual case with MP representing an eczematized response to a melanoma in situ and review the literature covering this entity. A 56-year-old man presented with a 6-month history of a pruritic, pigmented lesion on the trunk. The patient had no other significant medical history and no notable family history of similar lesions...
April 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27146778/a-clinicopathologic-study-of-malignant-melanoma-based-on-cytomorphology
#18
K Radhika, A K Prayaga, C Sundaram
CONTEXT: Melanoma accounts for 1-3% of all malignancies. It is usually diagnosed as metastasis in the draining lymph nodes, that is inguinal lymph node. Due to paucity of cytological studies on melanoma in India, the present study was undertaken. AIM: To study the cytomorphology of malignant melanoma and to correlate the cytological diagnosis with histopathology and clinical details. SETTINGS AND DESIGN: Sixteen cytomorphological features were studied and analysed from the cases diagnosed as melanoma on cytology with histopathological correlation...
January 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/26978003/clinicopathologic-analysis-of-stable-and-unstable-vitiligo-a-study-of-66-cases
#19
COMPARATIVE STUDY
Amit Kumar Yadav, Priyanka Singh, Niti Khunger
Vitiligo is an acquired skin disorder characterized by milky-white macules and absence of functioning melanocytes. The cornerstone of its management is the correct categorization of a case into its 2 broad types-stable and unstable vitiligo. This distinction is at present based mainly on clinical criteria because the histopathological features are not fully established. This study was thus undertaken to examine histopathological features of vitiligo and to come up with a reliable and systematic approach toward this diagnostic challenge...
August 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26892480/three-cases-of-pigmented-cosmetic-dermatitis-like-eruptions-associated-with-primary-sj%C3%A3-gren-s-syndrome-or-anti-ssa-antibody
#20
Naoko Takeo, Takashi Sakai, Tomoko Saito-Shono, Kazushi Ishikawa, Yutaka Hatano, Kazumoto Katagiri, Yoshihiro Takahashi, Kenji Kawano, Kenichi Kimoto, Toshiaki Kubota, Nobuoki Eshima, Hiroto Kojima, Sakuhei Fujiwara
Pigmented cosmetic dermatitis-like (Riehl's melanosis-like) pigmentation was reported in three of 27 patients with primary Sjögren's syndrome. But case reports of such eruptions are rare. We describe three cases of such eruptions associated with primary Sjögren's syndrome or anti-SSA antibody and possible associations with specific types of human leukocyte antigen (HLA) and infiltrating lymphocytes. These middle-aged Japanese women had reticular facial pigmentation and histopathological examination revealed interface dermatitis, melanophages, and dense lymphocytic infiltration around hair follicles and sweat ducts...
August 2016: Journal of Dermatology
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