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anti-obesity AND diabetes mellitus

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https://www.readbyqxmd.com/read/29881825/metabolic-risk-factors-are-associated-with-non-hepatitis-b-non-hepatitis-c-hepatocellular-carcinoma-in-taiwan-an-endemic-area-of-chronic-hepatitis-b
#1
Shiu-Feng Huang, Il-Chi Chang, Chih-Chen Hong, Tseng-Chang Yen, Chao-Long Chen, Cheng-Chung Wu, Cheng-Chung Tsai, Ming-Chih Ho, Wei-Chen Lee, Hsien-Chung Yu, Ying-Ying Shen, Hock-Liew Eng, John Wang, Hui-Hwa Tseng, Yung-Ming Jeng, Chau-Ting Yeh, Chi-Ling Chen, Pei-Jer Chen, Yun-Fan Liaw
Metabolic risk factors, such as obesity, fatty liver, high lipidemia, and diabetes mellitus are associated with increased risk for nonviral hepatocellular carcinoma (HCC); however, few nonviral HCC studies have stratified patients according to underlying etiologies. From 2005 to 2011, 3,843 patients with HCC were recruited into the Taiwan Liver Cancer Network. Of these patients, 411 (10.69%) who were negative for hepatitis B virus (HBV), surface antigen, HBV DNA, and anti-hepatitis C virus (HCV) antibody were classified as non-HBV non-HCV (NBNC)-HCC...
June 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29773198/serum-concentrations-of-trace-elements-and-their-relationships-with-paraoxonase-1-in-morbidly-obese-women
#2
Fedra Luciano-Mateo, Noemí Cabré, Martí Nadal, Anabel García-Heredia, Gerard Baiges-Gaya, Anna Hernández-Aguilera, Jordi Camps, Jorge Joven, José Luis Domingo
The metabolic alterations associated with obesity include mineral dysregulation. Essential trace elements are nutrients with a relevant function in a large number of cellular processes and multiple roles in the correct functioning of metabolic enzymes. Paraoxonase-1 (PON1) is an antioxidant and anti-inflammatory enzyme that is compromised in obesity. In the present study, the potential alterations in trace elements in morbidly obese women were assessed in relation to serum PON1 activity and concentration, as well as to other obesity-related comorbidities such as diabetes mellitus and fatty liver...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29754122/schizophrenia-and-type-2-diabetes-mellitus
#3
V Mamakou, A Thanopoulou, F Gonidakis, N Tentolouris, V Kontaxakis
Schizophrenia is associated with increased risk for type 2 diabetes mellitus, resulting in elevated cardiovascular risk and limited life expectancy, translated into a weighted average of 14.5 years of potential life lost and an overall weighted average life expectancy of 64.7 years. The exact prevalence of type 2 diabetes among people with schizophrenia varies across studies and ranges 2-5fold higher than in the general population, whereas the aetiology is complex and multifactorial. Besides common diabetogenic factors, applied similarly in the general population, such as obesity, hyperlipidemia, smoking, hypertension, poor diet and limited physical activity, the co-occurrence of schizophrenia and diabetes is also attributed to unique conditions...
January 2018: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29729352/pegylated-prodrugs-of-antidiabetic-peptides-amylin-and-glp-1
#4
Roland Böttger, Daniel Knappe, Ralf Hoffmann
Agonists of the glucagon-like peptide-1 (GLP-1) receptor and analogs of human amylin have been studied for almost two decades due to their therapeutic potential to treat diabetes mellitus and obesity. Both native peptides exhibit unfavorable pharmacokinetics. Even optimized analogs less prone to proteolysis have to be applied at least daily or once-weekly utilizing microsphere formulations or fusion to proteins. Thus, innovative approaches allowing tuning the drug levels to achieve beneficial therapeutic responses and prolonged application intervals are demanded...
May 2, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29726082/clinical-effectiveness-of-liraglutide-versus-basal-insulin-in-a-real-world-setting-evidence-for-improved-glycaemic-and-weight-control-in-obese-patients-with-type-2-diabetes
#5
Jetty Overbeek, Edith Heintjes, Eline Huisman, Christian Tikkanen, Arnout van Diermen, Fernie Penning-van Beest, Ron Herings
AIM: To compare real-world anti-diabetic treatment outcomes over 12 months in obese type 2 diabetes mellitus (T2DM) patients who previously received oral anti-diabetic (OAD) therapy and then initiated a first injectable therapy with liraglutide or basal insulin. MATERIALS AND METHODS: This was a retrospective, propensity score-matched, longitudinal cohort study using real-world data (January 2010 to December 2015) from the Dutch PHARMO Database Network. Adult obese (body mass index [BMI] ≥35 kg/m2 ) T2DM patients with ≥2 dispensing dates for liraglutide or basal insulin therapy (BOT) were selected...
May 3, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29721512/etanercept-induced-hypoglycemia-in-a-patient-with-psoriatic-arthritis-and-diabetes
#6
Emily C Pfeifer, David R Saxon, Robert W Janson
Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis and inflammation involving the axial skeleton and/or peripheral joints. It is more likely to be associated with metabolic syndrome and diabetes when compared with other inflammatory arthritides. Tumor necrosis factor-α (TNF-α) is one of several cytokines often elevated in rheumatologic disorders including PsA and has also been found to be elevated in patients with obesity, metabolic syndrome, diabetes, and/or atherosclerotic disease...
July 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29693586/ellagic-acid-alleviates-hepatic-oxidative-stress-and-insulin-resistance-in-diabetic-female-rats
#7
Simran Alexandria Polce, Cameron Burke, Lucas Martins França, Benjamin Kramer, Antonio Marcus de Andrade Paes, Maria Alicia Carrillo-Sepulveda
Non-alcoholic fatty liver disease (NAFLD) affects more than 70% of patients with type 2 diabetes mellitus (T2DM) and has become one of the most common metabolic liver diseases worldwide. To date, treatments specifically targeting NAFLD do not exist. Oxidative stress and insulin resistance have been implicated in the pathogenesis of NAFLD in diabetes. Accordingly, the goal of this present study was to determine whether Ellagic acid (EA), a natural antioxidant polyphenol found in berries and nuts, mitigates hepatic oxidative stress and insulin resistance in T2DM rats, and thus alleviates NAFLD...
April 25, 2018: Nutrients
https://www.readbyqxmd.com/read/29677533/proresolving-protein-annexin-a1-the-role-in-type-2-diabetes-mellitus-and-obesity
#8
Nathalia T Pietrani, Cláudia N Ferreira, Kathryna F Rodrigues, Luiza O Perucci, Fernanda S Carneiro, Adriana A Bosco, Marina C Oliveira, Solange S Pereira, Antônio L Teixeira, Jacqueline I Alvarez-Leite, Adaliene V Ferreira, Lirlândia P Sousa, Karina B Gomes
BACKGROUND: Annexin A1 (AnxA1) is a protein involved in inflammation resolution that might be altered in obesity-associated type 2 diabetes mellitus (DM), which is a chronic inflammatory disease. The aim of this study was to evaluate AnxA1 serum levels in individuals with and without DM stratified according to the body mass index (BMI), and the dynamic of AnxA1 expression in adipose tissue from humans with obesity and non-obesity. METHODS: Serum samples were obtained from 41 patients with DM (lean, overweight and obese) and 40 controls, and adipose tissue samples were obtained from 16 individuals with obesity (with or without DM), and 15 controls...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29660843/mortality-after-a-cerebrovascular-event-in-age-related-macular-degeneration-patients-treated-with-bevacizumab-ocular-injections
#9
Joel Hanhart, Doron S Comaneshter, Shlomo Vinker
PURPOSE: To analyse the mortality associated with intravitreal injections of bevacizumab for age-related macular degeneration (AMD) in patients previously diagnosed with stroke or transient ischaemic attack (TIA). METHODS: We reviewed bevacizumab-treated AMD patients with a diagnosis of stroke or TIA prior to their first bevacizumab injection (n = 948). Those patients, naïve to any anti-vascular endothelial growth factor (anti-VEGF) at the time of stroke/TIA, were then compared to age- and gender-matched patients who had a stroke/TIA at the same time and had never been exposed to anti-VEGF...
April 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29623823/low-25-hydroxyvitamin-d-levels-are-independently-associated-with-autoimmune-thyroiditis-in-a-cohort-of-apparently-healthy-overweight-and-obese-subjects
#10
Giovanni De Pergola, Vincenzo Triggiani, Nicola Bartolomeo, Vito Angelo Giagulli, Michele Anelli, Michele Masiello, Vittoria Candita, Dario De Bellis, Franco Silvestris
BACKGROUND: Low vitamin D levels have been associated with autoimmune disorders and, then, with the Hashimoto's autoimmune thyroiditis (AT), the most common autoimmune disease. Obesity is characterized by lower vitamin D levels and higher risk to develop autoimmune diseases. The aim of the study was to examine the possibility of an association between AT and decreased 25(OH) vitamin D (25(OH)D) levels in a cohort of otherwise healthy overweight and obese subjects. MATERIALS AND METHODS: Two hundred sixty one overweight subjects (mean age: 40...
April 6, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29601978/prolactin-regulatory-element-binding-preb-protein-regulates-hepatic-glucose-homeostasis
#11
Joo-Man Park, Mi-Young Kim, Tae-Hyun Kim, Dong-Kook Min, Ga Eul Yang, Yong-Ho Ahn
Prolactin regulatory element-binding (PREB) protein is a transcription factor that regulates prolactin (PRL) gene expression. PRL, also known as luteotropic hormone or luteotropin, is well known for its role in producing milk. However, the role of PREB, in terms of hepatic glucose metabolism, is not well elucidated. Here, we observed expression of Preb in the mouse liver, in connection with glucose homeostasis. Morevoer, Preb was downregulated in db/db, ob/ob and high-fat diet-induced obese (DIO) mice, concurrent with upregulation of the liver genes glucose-6-phosphatase (G6pc) and phosphoenolpyruvate carboxykinase-1 (Pck)...
June 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29601492/obesity-inflammation-toll-like-receptor-4-and-fatty-acids
#12
REVIEW
Marcelo Macedo Rogero, Philip C Calder
Obesity leads to an inflammatory condition that is directly involved in the etiology of cardiovascular diseases, type 2 diabetes mellitus, and certain types of cancer. The classic inflammatory response is an acute reaction to infections or to tissue injuries, and it tends to move towards resolution and homeostasis. However, the inflammatory process that was observed in individuals affected by obesity and metabolic syndrome differs from the classical inflammatory response in certain respects. This inflammatory process manifests itself systemically and it is characterized by a chronic low-intensity reaction...
March 30, 2018: Nutrients
https://www.readbyqxmd.com/read/29580285/pioglitazone-is-effective-for-multiple-phenotyepes-of-the-zucker-fa-fa-rat-with-polycystc-ovary-morphology-and-insulin-resistance
#13
Miyuki Morishita, Toshiaki Endo, Tsuyoshi Baba, Yoshika Kuno, Keiko Ikeda, Tamotsu Kiya, Hiroyuki Honnma, Tsuyoshi Saito
BACKGROUND: Hyperandrogenism and insulin resistance may be related to the etiology of PCOS. Zucker fa/fa rats with polycystic ovary are obese, have insulin resistance without diabetes mellitus or hyperandrogenism and can be utilized as PCOS model rats without effects of hyperandrogenemia. PCOS patients are reported to have elevated levels of serum anti-Mullerian hormone (AMH), which has an inhibitory action on folliculogenesis, and low levels of serum adiponectin, which blocks apoptosis and induces biological effects in some tissues...
March 27, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29559690/estimated-glomerular-filtration-ratio-is-a-better-index-than-creatinine-clearance-cockcroft-gault-for-predicting-the-prevalence-of-atrial-fibrillation-in-the-general-japanese-population
#14
Yutaka Yonezawa, Shigeo Horinaka, Chiaki Shirakawa, Yoshio Kogure
Direct oral anti-coagulants (DOACs) have been used in patients with non-valvular atrial fibrillation (AF), and renal function evaluation using the CCr (Cockcroft-Gault) is recommended as a criterion for the reduction of DOAC. In contrast, estimated glomerular filtration rate (eGFR) is usually used as an index of renal function in daily practice. We determined the age- and gender-specific prevalence rates of AF and whether CCr or eGFR was associated with the prevalence of AF. Data from the periodic health examinations of 108,951 subjects were collected...
June 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29524863/the-gut-microbiome-and-elevated-cardiovascular-risk-in-obesity-and-autoimmunity
#15
REVIEW
Lora J Kasselman, Nicholas A Vernice, Joshua DeLeon, Allison B Reiss
Cardiovascular disease associated with obesity and autoimmunity is the leading cause of death in these populations and significant residual risk remains despite current treatment approaches. Obesity, type 1 diabetes mellitus (T1DM), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) are linked to chronic inflammation, and subjects with these disorders have characteristic shifts in their gut microbiome composition. Recent data suggest that alterations in gut microbial and metabolic composition may be responsible, in part, for induction of chronic inflammation, thus promoting cardiovascular disease...
April 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29523882/hiv-based-lentivirus-mediated-vasoactive-intestinal-peptide-gene-delivery-protects-against-dio-animal-model-of-type-2-diabetes
#16
Hale M Tasyurek, Yunus E Eksi, Ahter D Sanlioglu, Hasan A Altunbas, Mustafa K Balci, Thomas S Griffith, Salih Sanlioglu
Type 2 diabetes mellitus (T2DM) is characterised by insulin resistance, glucose intolerance and beta cell loss leading to hyperglycemia. Vasoactive intestinal peptide (VIP) has been regarded as a novel therapeutic agent for the treatment of T2DM because of its insulinotropic and anti-inflammatory properties. Despite these beneficial properties, VIP is extremely sensitive to peptidases (DPP-4) requiring constant infusion or multiple injections to observe any therapeutic benefit. Thus, we constructed an HIV-based lentiviral vector encoding human VIP (LentiVIP) to test the therapeutic efficacy of VIP peptide in a diet-induced obesity (DIO) animal model of T2DM...
March 9, 2018: Gene Therapy
https://www.readbyqxmd.com/read/29510088/vaginal-antimycotics-and-the-risk-for-spontaneous-abortions
#17
Sharon Daniel, Reut Rotem, Gideon Koren, Eitan Lunenfeld, Amalia Levy
BACKGROUND: Spontaneous abortions are the most common complication of pregnancy. Clotrimazole and miconazole are widely used vaginal-antimycotic agents used for the treatment of vulvovaginal candidiasis. A previous study has suggested an increased risk of miscarriage associated with these azoles, which may lead health professionals to refrain from their use even if clinically indicated. OBJECTIVE: The aim of the current study was to assess the risk for spontaneous abortions following first trimester exposure to vaginal antimycotics...
March 3, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29502278/the-effects-of-laparoscopic-sleeve-gastrectomy-with-duodenojejunal-bypass-on-japanese-patients-with-bmi-35-kg-m-2-on-type-2-diabetes-mellitus-and-the-prediction-of-successful-glycemic-control
#18
Yosuke Seki, Kazunori Kasama, Kazuki Yasuda, Renzo Yokoyama, Jose Paolo Porciuncula, Yoshimochi Kurokawa
BACKGROUND: Laparoscopic sleeve gastrectomy with duodenojejunal bypass (LSG-DJB) is a combination of sleeve gastrectomy and proximal intestinal bypass through duodenal exclusion. This technique has shown excellent weight loss and anti-diabetic effects in severely obese patients. In this retrospective study, we examined the clinical effects of LSG-DJB on mildly obese patients (body mass index (BMI) < 35 kg/m2 ) with type 2 diabetes mellitus (T2DM) and analyzed factors contributing to the successful postoperative glycemic control...
March 3, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29498254/type-2-diabetes-mellitus-risk-and-exercise-is-resistin-involved
#19
Christian Cobbold
Obesity and associated disorders such as type 2 diabetes mellitus (T2DM) pose an increasing risk to the health of both individuals and society. Adipose tissue is an active endocrine organ, secreting many hormones, known as adipokines. Evidence suggests that one suggest adipokine, resistin, may be elevated in the plasma of individuals with T2DM, and early reports indicated that this may contribute to the impaired glucose tolerance and insulin resistance observed in T2DM, hence its name, resistin, however subsequent evidence suggests it may have a proinflammatory role...
March 1, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29452073/the-role-of-adiponectin-and-adipolin-as-anti-inflammatory-adipokines-in-the-formation-of-macrophage-foam-cells-and-their-association-with-cardiovascular-diseases
#20
REVIEW
Javad Sargolzaei, Elham Chamani, Tooba Kazemi, Soudabeh Fallah, Hosna Soori
Obesity is one of the major public health concerns that is closely associated with obesity-related disorders such as type 2 diabetes mellitus (T2DM), hypertension, and atherosclerosis. Atherosclerosis is a chronic disease characterized by excess cholesterol deposition in the arterial intima and the formation of foam cells. Adipocytokines or adipokines are secreted by the adipose tissue as endocrine glands; adiponectin and adipolin are among these adipokines that are associated with obese and insulin-resistant phenotypes...
April 2018: Clinical Biochemistry
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