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anti-obesity AND diabetes mellitus

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https://www.readbyqxmd.com/read/29452073/the-role-of-adiponectin-and-adipolin-as-anti-inflammatory-adipokines-in-the-formation-of-macrophage-foam-cells-and-their-association-with-cardiovascular-diseases
#1
REVIEW
Javad Sargolzaei, Elham Chamani, Tooba Kazemi, Soudabeh Fallah, Hosna Soori
Obesity is one of the major public health concerns that is closely associated with obesity-related disorders such as type 2 diabetes mellitus (T2DM), hypertension, and atherosclerosis. Atherosclerosis is a chronic disease characterized by excess cholesterol deposition in the arterial intima and the formation of foam cells. Adipocytokines or adipokines are secreted by the adipose tissue as endocrine glands; adiponectin and adipolin are among these adipokines that are associated with obese and insulin-resistant phenotypes...
February 13, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29437902/maternal-resveratrol-consumption-and-its-programming-effects-on-metabolic-health-in-offspring-mechanisms-and-potential-implications
#2
Sheng Zheng, Qianyun Feng, Jing Cheng, Jia Zheng
A growing body of evidence has clearly demonstrated that maternal nutrition can strongly determine the susceptibility to the development of metabolic diseases in offspring. With the increasing prevalence of maternal overweight, obesity, and gestational diabetes mellitus, it yields enormous burden for individual and public health. Interventions during pregnancy have been proven to be challenging, with limited efficacy and low compliance. Resveratrol, as a natural polyphenolic compound, has a wide-range of beneficial properties, including potent anti-obesogenic, anti-atherosclerotic, and anti-diabetic effects...
February 5, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29421161/therapies-for-gestational-diabetes-and-their-implications-for-maternal-and-offspring-health-evidence-from-human-and-animal-studies
#3
REVIEW
Gabriel M Brawerman, Vernon W Dolinsky
Obesity prior to and during pregnancy is associated with an increased risk of complications during pregnancy. One of the most common complications of pregnancy is gestational diabetes mellitus (GDM), a condition characterized by hyperglycemia and insulin resistance that is diagnosed in the third trimester of pregnancy. GDM predisposes both mothers and their children to increased obesity and cardiometabolic disorders, namely type 2 diabetes and cardiovascular disease. Current treatments include lifestyle changes and insulin injections, but oral anti-diabetic drugs such as metformin and glyburide are increasingly prescribed as they do not require injections...
February 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29416195/assessment-of-pharmacological-responses-to-an-anti-diabetic-drug-in-a-new-obese-type-2-diabetic-rat-model
#4
Yasutaka Murai, Takeshi Ohta, Hironobu Tadaki, Katsuhiro Miyajima, Masami Shinohara, Fatchiyah Fatchiyah, Takahisa Yamada
Introduction: The number of diabetic patients has recently been increasing worldwide, and numerous anti-diabetic drugs have been developed to induce good glycemic control. In particular, metformin, which exhibits glucose-lowering effects by suppressing gluconeogenesis in the liver, is widely used as a first line oral anti-diabetic drug for type 2 diabetes mellitus. Material and Methods: In this study, the pharmacological effects of metformin were investigated using female and male Spontaneously Diabetic Torii (SDT) fatty rats, a new obese type 2 diabetic model...
December 2017: Medical Archives
https://www.readbyqxmd.com/read/29376231/diabetic-retinopathy-in-the-asia-pacific
#5
Jacqueline Chua, Claire Xin Ying Lim, Tien Yin Wong, Charumathi Sabanayagam
Diabetic retinopathy (DR), the most common complication of diabetes mellitus, is the leading cause of new cases of blindness in middle-aged and elderly in the Asia-Pacific. It has been estimated that 51% of all those with blindness due to DR globally (n = 424,400) and 56% of those with visual impairment due to DR (2.1 million) come from the Asia-Pacific. Prevalence of DR among those with diabetes ranged from 10% in India to 43% in Indonesia within the Asia-Pacific. Awareness of DR among persons with diabetes ranged from 28% to 84%...
January 26, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29344438/new-therapeutic-approaches-in-obesity-and-metabolic-syndrome-associated-with-polycystic-ovary-syndrome
#6
REVIEW
Fatima Saleem, Syed W Rizvi
Polycystic ovary syndrome (PCOS) is a pathophysiological disorder affecting reproductive and metabolic indices. PCOS is commonly associated with a high prevalence of insulin resistance and obesity; this association carries an increased risk of developing metabolic syndrome, type 2 diabetes mellitus (T2DM), and cardiovascular disease. Guidelines recommend lifestyle modification, metformin, hormonal contraceptives (HCs), and bariatric surgery as the main treatment options in obese patients with PCOS. Studies are being conducted to test the efficacy of existing treatment options as well as to discover new therapies...
November 13, 2017: Curēus
https://www.readbyqxmd.com/read/29343256/the-effects-of-green-cardamom-supplementation-on-blood-glucose-lipids-profile-oxidative-stress-sirtuin-1-and-irisin-in-type-2-diabetic-patients-a-study-protocol-for-a-randomized-placebo-controlled-clinical-trial
#7
Mohadeseh Aghasi, Shohreh Ghazi-Zahedi, Fariba Koohdani, Fereydoun Siassi, Ensieh Nasli-Esfahani, Ali Keshavarz, Mostafa Qorbani, Hoorieh Khoshamal, Asma Salari-Moghaddam, Gity Sotoudeh
BACKGROUND: It has been suggested that the antioxidant, anti-inflammatory and hypolipidemic activities of cardamom may improve diabetes. However, the effect of this spice has not been investigated in diabetic subjects. This study was planned to determine the effects of green cardamom on blood glucose, lipids and oxidative stress status in type 2 diabetic patients. METHODS/DESIGN: Eighty overweight or obese patients with type 2 diabetes will be selected. They will be randomly assigned to receive 3 g/d green cardamom or placebo for 10 weeks...
January 17, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29339732/glyburide-and-retinoic-acid-synergize-to-promote-wound-healing-by-anti-inflammation-and-rip140-degradation
#8
Yi-Wei Lin, Pu-Ste Liu, Kasey Ah Pook, Li-Na Wei
Chronic inflammation underlies the development of metabolic diseases and individuals with metabolic disease often also suffer from delayed wound healing due to prolonged inflammation. Resolving inflammation provides a therapeutic strategy in treating metabolic diseases. We previously showed that during an anti-inflammatory response when macrophages were alternatively (M2) polarized, retinoic acid (RA) dramatically activated arginase 1 gene (Arg1), a gene crucial for wound healing. Here we report that a widely used sulfonylurea drug for type 2 diabetes mellitus (T2DM), glyburide, enhances the anti-inflammatory response and synergizes with RA to promote wound healing...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29302369/long-term-follow-up-for-type-2-diabetes-mellitus-after-gastrectomy-in-non-morbidly-obese-patients-with-gastric-cancer-the-legitimacy-of-onco-metabolic-surgery
#9
Tae-Hoon Lee, Chang Min Lee, Sungsoo Park, Do Hyun Jung, You Jin Jang, Jong-Han Kim, Seong-Heum Park, Young-Jae Mok
Purpose: This study primarily aimed to investigate the short- and long-term remission rates of type 2 diabetes (T2D) in patients who underwent surgical treatment for gastric cancer, especially patients who were non-obese, and secondarily to determine the potential factors associated with remission. Materials and Methods: We retrospectively reviewed the clinical records of patients with T2D who underwent radical gastrectomy for gastric cancer, from January 2008 to December 2012...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29290500/palmitic-and-oleic-acid-the-yin-and-yang-of-fatty-acids-in-type-2-diabetes-mellitus
#10
REVIEW
Xavier Palomer, Javier Pizarro-Delgado, Emma Barroso, Manuel Vázquez-Carrera
Increased plasma non-esterified fatty acids (NEFAs) link obesity with insulin resistance and type 2 diabetes mellitus (T2DM). However, in contrast to the saturated FA (SFA) palmitic acid, the monounsaturated FA (MUFA) oleic acid elicits beneficial effects on insulin sensitivity, and the dietary palmitic acid:oleic acid ratio impacts diabetes risk in humans. Here we review recent mechanistic insights into the beneficial effects of oleic acid compared with palmitic acid on insulin resistance and T2DM, including its anti-inflammatory actions, and its capacity to inhibit endoplasmic reticulum (ER) stress, prevent attenuation of the insulin signaling pathway, and improve β cell survival...
December 28, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29241364/health-benefits-of-pistachios-consumption
#11
Simona Terzo, Sara Baldassano, Gaetano Felice Caldara, Vincenzo Ferrantelli, Gianluigi Lo Dico, Flavia Mulè, Antonella Amato
The health benefits of nuts, mainly in relation to the improvement of dysmetabolic conditions such as obesity, type 2 diabetes mellitus and the related cardiovascular diseases, have been widely demonstrated. Compared to other nuts, pistachios have a lower fat and caloric content, and contain the highest levels of unsaturated fatty acids, potassium, γ-tocopherol, phytosterols and xanthophyll carotenoids, all substances that are well known for their antioxidant and anti-inflammatory actions. This variety of nutrients contributes to the growing body of evidence that the consumption of pistachios improves health, leading to a greater potential of healthy antioxidant and anti-inflammatory activity, glycemic control, and endothelial function...
December 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29235014/increased-bile-acid-signals-after-duodenal-jejunal-bypass-improve-non-alcoholic-steatohepatitis-nash-in-a-rodent-model-of-diet-induced-nash
#12
Takahiro Tsuchiya, Takeshi Naitoh, Munenori Nagao, Naoki Tanaka, Kazuhiro Watanabe, Hirofumi Imoto, Tomohiro Miyachi, Fuyuhiko Motoi, Michiaki Unno
BACKGROUND: The increasing incidence of non-alcoholic steatohepatitis (NASH) has resulted in it becoming a common cause of liver-related mortality; however, no efficient treatment has been established. It has been reported that bariatric surgery improves metabolic comorbidities, such as diabetes mellitus and NASH. Although the mechanism is unclear, it is thought that the changes in bile acid (BA) signaling via its nuclear receptor, farnesoid X receptor (FXR), produce various metabolic effects...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29232311/lithium-colchicine-a-potential-strategy-to-reduce-pro-inflammatory-effects-of-lithium-treatment
#13
John J Mooney, Roscoe O Brady
PURPOSE: Rosenblat and McIntyre (Acta Psychiatr Scand. 2015;132: 180-191) propose that immune disorders are important mediators between bipolar disorders and medical comorbidities. Rosenblat et al (Bipolar Disord. 2016;18:89-101) present a meta-analysis showing that adjunctive anti-inflammatory agents could evoke moderate antidepressant responses in bipolar disorders. We propose using the anti-inflammatory drug colchicine to improve the long-term safety and efficacy of lithium treatment for bipolar disorders...
February 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29227039/mid-term-results-of-bariatric-surgery-in-morbidly-obese-japanese-patients-with-slow-progressive-autoimmune-diabetes
#14
Kohei Uno, Yosuke Seki, Kazunori Kasama, Kotaro Wakamatsu, Kenkichi Hashimoto, Akiko Umezawa, Katsuhiko Yanaga, Yoshimochi Kurokawa
INTRODUCTION: Bariatric surgery is recognized as an effective treatment for type 2 diabetes mellitus, but data on its efficacy for type 1 diabetes mellitus, especially slowly progressive insulin-dependent diabetes mellitus, are limited. METHODS: We investigated five Japanese patients with slowly progressive insulin-dependent diabetes mellitus who underwent bariatric surgery at our center. RESULTS: Five morbidly obese glutamic acid decarboxylase antibody-positive diabetic patients underwent two different types of bariatric surgery...
December 11, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29216336/managing-diabetic-kidney-disease
#15
Sagen Zac-Varghese, Peter Winocour
Introduction: Diabetes mellitus (DM) is the leading cause of chronic kidney disease (CKD). This review covers the pillars of care essential for the management of diabetic kidney disease (DKD) including (1) early diagnosis, (2) improved glycaemic control, (3) treatment of hypertension, (4) identification and treatment of associated metabolic bone disease and (5) identification and effective management of dyslipidaemia and additional cardiovascular risk factors. Sources of data: We searched PubMed for articles using search terms: diabetic nephropathy, diabetic kidney disease, diabetes and chronic kidney disease...
December 5, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29216237/the-nutraceutical-benefits-of-subfractions-of-abelmoschus-esculentus-in-treating-type-2-diabetes-mellitus
#16
Chien-Ning Huang, Chau-Jong Wang, Chih-Li Lin, Hui-Ting Lin, Chiung-Huei Peng
Abelmoschus esculentus (AE), a commonly consumed vegetable, is well-known for its anti-hyperglycemic effects. However, few scientific reports have identified its targets because mucilage increases the difficulty of manipulation. We recently reported extraction steps to obtain subfractions of AE, which were found to attenuate the adverse effects of high glucose and fatty acid in vitro. In this study, we used modified extraction steps and type 2 diabetic rats to explore whether AE subfractions can improve the metabolic disturbances caused by insulin resistance in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/29189508/steroid-induced-hypertension-during-induction-chemotherapy-for-acute-lymphoblastic-leukemia-in-us-children-s-hospitals
#17
Ian Bakk, Terah Koch, Joseph Stanek, Sarah H O'Brien, Suzanne Reed
Childhood acute lymphoblastic leukemia achieves excellent cure rates in part due to induction chemotherapy including high dose corticosteroids. Hypertension (HTN) is a known complication of corticosteroids, but incidence and risk factors for steroid-induced HTN are poorly understood. We sought to describe these using a large pediatric health database. Of the 5578 unique patients receiving induction chemotherapy, 14.7% received anti-HTN medications during their initial hospital admission. We found that age below 1 year, obesity, secondary diabetes mellitus, and abnormal glucose were associated with developing steroid-induced HTN...
January 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29181668/melatonin-aluminum-oxide-polymethylsiloxane-complex-on-apoptosis-of-liver-cells-in-a-model-of-obesity-and-type-2-diabetes-mellitus
#18
S V Michurina, I Yu Ischenko, S A Arkhipov, V V Klimontov, M A Cherepanova, M A Korolev, L N Rachkovskaya, E L Zav'yalov, V I Konenkov
We studied the effects of a melatonin-aluminum oxide-polymethylsiloxane complex (complex M) on the expression of apoptosis regulators Bcl-2 and Bad in the liver of homozygous db/db BKS.Cg-Dock7m+/+Leprdb/J mice with obesity and type 2 diabetes. Complex M or placebo was administered daily through the gastric tube during weeks 8-16 of life. In mice with type 2 diabetes mellitus receiving placebo, enhanced immunohistochemical reactions for proapoptotic Bad protein and weak response for anti-apoptotic Bcl-2 protein were observed...
November 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29142551/association-of-single-nucleotide-missence-polymorphism-val109asp-of-omentin-1-gene-and-coronary-artery-disease-in-pakistani-population-multicenter-study
#19
Shazia Nazar, Sitwat Zehra, Abid Azhar
Background & Objective: Coronary artery disease (CAD) is a most important cause of morbidity and mortality worldwide as well as in Pakistan. Recent studies have shown that the combination of obesity, insulin resistance and fluctuation in circulating adipocytokines levels is associated with the pathogenesis of coronary artery disease. Omentin-1 is recently found adipocytokine that is highly expressed in visceral adipose tissue. It has anti- inflammatory properties and is negatively correlated with ischemic heart disease...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29119583/hyperlipidemia-is-associated-with-an-increased-risk-of-clinical-benign-prostatic-hyperplasia
#20
Hung-Jen Shih, Chun-Jen Huang, Jui-An Lin, Ming-Chang Kao, Yen-Chun Fan, Pei-Shan Tsai
BACKGROUND: A high fat diet is associated with risk of benign prostatic hyperplasia (BPH). However, whether hyperlipidemia is associated with BPH remains unclear. This population-based cohort study elucidated whether hyperlipidemia is associated with an increased risk of BPH. METHODS: We used a new-exposure design and analyzed data retrieved from the Taiwan National Health Insurance Database between January 1, 2000 and December 31, 2013. The cohort of men with newly diagnosed hyperlipidemia and the age- and index-date-matched (1:3) nonhyperlipidemia cohort were tracked for incidence of BPH during a 1- to 14-year follow-up...
February 2018: Prostate
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