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stem cell therapy for Acute lung injury

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https://www.readbyqxmd.com/read/27873515/angiopoietin-1-modified-human-umbilical-cord-mesenchymal-stem-cell-therapy-for-endotoxin-induced-acute-lung-injury-in-rats
#1
Zhi Wei Huang, Ning Liu, Dong Li, Hai Yan Zhang, Ying Wang, Yi Liu, Le Ling Zhang, Xiu Li Ju
PURPOSE: Angiopoietin-1 (Ang1) is a critical factor for vascular stabilization and endothelial survival via inhibition of endothelial permeability and leukocyte- endothelium interactions. Hence, we hypothesized that treatment with umbilical cord mesenchymal stem cells (UCMSCs) carrying the Ang1 gene (UCMSCs-Ang1) might be a potential approach for acute lung injury (ALI) induced by lipopolysaccharide (LPS). MATERIALS AND METHODS: UCMSCs with or without transfection with the human Ang1 gene were delivered intravenously into rats one hour after intra-abdominal instillation of LPS to induce ALI...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27861182/cryopreserved-xeno-free-human-umbilical-cord-mesenchymal-stromal-cells-reduce-lung-injury-severity-and-bacterial-burden-in-rodent-escherichia-coli-induced-acute-respiratory-distress-syndrome
#2
Gerard F Curley, Mirjana Jerkic, Steve Dixon, Grace Hogan, Claire Masterson, Daniel O'Toole, James Devaney, John G Laffey
OBJECTIVE: Although mesenchymal stem/stromal cells represent a promising therapeutic strategy for acute respiratory distress syndrome, clinical translation faces challenges, including scarcity of bone marrow donors, and reliance on bovine serum during mesenchymal stem/stromal cell proliferation. We wished to compare mesenchymal stem/stromal cells from human umbilical cord, grown in xeno-free conditions, with mesenchymal stem/stromal cells from human bone marrow, in a rat model of Escherichia coli pneumonia...
November 16, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27821556/amnion-epithelial-cells-promote-lung-repair-via-lipoxin-a4
#3
Jean L Tan, Yan Z Tan, Ruth Muljadi, Siow T Chan, Sin N Lau, Joanne C Mockler, Euan M Wallace, Rebecca Lim
: : Human amnion epithelial cells (hAECs) have been shown to possess potent immunomodulatory properties across a number of disease models. Recently, we reported that hAECs influence macrophage polarization and activity, and that this step was dependent on regulatory T cells. In this study, we aimed to assess the effects of hAEC-derived proresolution lipoxin-A4 (LXA4) on T-cell, macrophage, and neutrophil phenotype and function during the acute phase of bleomycin-induced lung injury. Using C57Bl6 mice, we administered 4 million hAECs intraperitoneally 24 hours after bleomycin challenge...
November 7, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27644345/evidence-that-bone-marrow-derived-mesenchymal-stem-cells-reduce-epithelial-permeability-following-phosgene-induced-acute-lung-injury-via-activation-of-wnt3a-protein-induced-canonical-wnt-%C3%AE-catenin-signaling
#4
Jing Zhang, Yiru Shao, Daikun He, Lin Zhang, Guoxiong Xu, Jie Shen
: An increase in epithelial cell permeability has been proposed to contribute to phosgene-induced acute lung injury (ALI). However, no specific and effective means for blocking increases in permeability are currently available. Cell-based therapy using bone marrow-derived mesenchymal stem cells (MSCs) is an attractive new approach. Canonical wnt/β-catenin signaling has been demonstrated to contribute to both epithelial cell injury and repair mechanisms in ALI. The goal of our study was to determine the effects of MSCs on epithelial permeability in phosgene-induced ALI in Sprague-Dawley (SD) rats and identify changes in major components of the wnt3a/β-catenin signaling pathway during this process...
October 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27572073/mesenchymal-stem-cell-therapy-protects-lungs-from-radiation-induced-endothelial-cell-loss-by-restoring-superoxide-dismutase-1-expression
#5
Diana Klein, Jennifer Steens, Alina Wiesemann, Florian Christoph Schulz, Farnusch Kaschani, Katharina Roeck, Masahiro Yamaguchi, Florian Wirsdörfer, Markus Kaiser, Jens Fischer, Martin Stuschke, Verena Jendrossek
AIMS: Radiation-induced normal tissue toxicity is closely linked to endothelial cell (EC) damage and dysfunction (acute effects). However, the underlying mechanisms of radiation-induced adverse late effects with respect to the vascular compartment remain elusive and no causative radioprotective treatment is available to date. RESULTS: The importance of injury to EC for radiation-induced late toxicity in lungs after whole thorax irradiation (WTI) was investigated using a mouse model of radiation-induced pneumopathy...
August 29, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27556817/hepatocyte-growth-factor-modified-mesenchymal-stem-cells-improve-ischemia-reperfusion-induced-acute-lung-injury-in-rats
#6
S Chen, X Chen, X Wu, S Wei, W Han, J Lin, M Kang, L Chen
Accumulative evidence demonstrated that mesenchymal stem cell (MSC) engraftment could protect tissue injury from ischemia/reperfusion (I/R). Hepatocyte growth factor (HGF) has important roles in the cell and tissue repairment and regeneration. Here we investigated the enhanced effects of HGF-modified MSCs on I/R-induced acute lung injury. Rat bone marrow-derived MSCs were successfully transfected to express HGF. HGF modification did not affect the characteristics of MSCs, and increased MSC viability, and inhibit the proinflammatory phenotype of MSCs in the inflammatory condition...
September 22, 2016: Gene Therapy
https://www.readbyqxmd.com/read/27531647/advances-in-stem-cell-and-cell-based-gene-therapy-approaches-for-experimental-acute-lung-injury-a-review-of-preclinical-studies
#7
Shirley Hsin-Ju Mei, Claudia Dos Santos, Duncan Stewart
Given the failure of pharmacological interventions in acute respiratory distress syndrome (ARDS), researchers have been actively pursuing novel strategies to treat this devastating, life-threatening condition commonly seen in the Intensive Care Unit. There has been considerable research on harnessing the reparative properties of stem and progenitor cells to develop more effective therapeutic approaches for respiratory diseases with limited treatment options like ARDS. This review will discuss the preclinical literature on the use of stem and progenitor cell therapy and cell-based gene therapy for the treatment of preclinical animal models of acute lung injury (ALI)...
August 16, 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27496218/high-variability-in-the-reported-management-of-hepatic-veno-occlusive-disease-in-children-after-hematopoietic-stem-cell-transplantation
#8
Micah A Skeens, Jennifer McArthur, Ira M Cheifetz, Christine Duncan, Adrienne G Randolph, Joseph Stanek, Leslie Lehman, Rajinder Bajwa
Veno-occlusive disease (VOD) is a potentially fatal complication of hematopoietic stem cell transplantation (HSCT). Patients with VOD are often critically ill and require close collaboration between transplant physicians and intensivists. We surveyed members of a consortium of pediatric intensive care unit (PICU) and transplant physicians to assess variability in the self-reported approach to the diagnosis and management of VOD. An internet-based self-administered survey was sent to pediatric HSCT and PICU providers from September 2014 to February 2015...
October 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27487912/a-simple-and-robust-bedside-model-for-mortality-risk-in-pediatric-patients-with-acute-respiratory-distress-syndrome
#9
Aaron C Spicer, Carolyn S Calfee, Matthew S Zinter, Robinder G Khemani, Victoria P Lo, Mustafa F Alkhouli, Benjamin E Orwoll, Ana L Graciano, Juan P Boriosi, James P Howard, Heidi R Flori, Michael A Matthay, Anil Sapru
OBJECTIVES: Despite declining mortality, acute respiratory distress syndrome is still involved in up to one third of pediatric intensive care deaths. The recently convened Pediatric Acute Lung Injury Consensus Conference has outlined research priorities for the field, which include the need for accurate bedside risk stratification of patients. We aimed to develop a simple yet robust model of mortality risk among pediatric patients with acute respiratory distress syndrome to facilitate the targeted application of high-risk investigational therapies and stratification for enrollment in clinical trials...
October 2016: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27408702/recent-insights-mesenchymal-stromal-stem-cell-therapy-for-acute-respiratory-distress-syndrome
#10
REVIEW
Shahd Horie, John G Laffey
Acute respiratory distress syndrome (ARDS) causes respiratory failure, which is associated with severe inflammation and lung damage and has a high mortality and for which there is no therapy. Mesenchymal stromal/stem cells (MSCs) are adult multi-progenitor cells that can modulate the immune response and enhance repair of damaged tissue and thus may provide a therapeutic option for ARDS. MSCs demonstrate efficacy in diverse in vivo models of ARDS, decreasing bacterial pneumonia and ischemia-reperfusion-induced injury while enhancing repair following ventilator-induced lung injury...
2016: F1000Research
https://www.readbyqxmd.com/read/27385791/therapeutic-regulatory-t-cell-adoptive-transfer-ameliorates-established-murine-chronic-gvhd-in-a-cxcr5-dependent-manner
#11
Cameron McDonald-Hyman, Ryan Flynn, Angela Panoskaltsis-Mortari, Nicholas Peterson, Kelli P A MacDonald, Geoffrey R Hill, Leo Luznik, Jonathan S Serody, William J Murphy, Ivan Maillard, David H Munn, Laurence A Turka, John Koreth, Corey S Cutler, Robert J Soiffer, Joseph H Antin, Jerome Ritz, Bruce R Blazar
Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation. In cGVHD, alloreactive T cells and germinal center (GC) B cells often participate in GC reactions to produce pathogenic antibodies. Although regulatory T cells (Tregs) can inhibit GC reactions, Treg numbers are reduced in cGVHD, contributing to cGVHD pathogenesis. Here, we explored 2 means to increase Tregs in cGVHD: interleukin-2/monoclonal antibody (IL-2/mAb) complexes and donor Treg infusions...
August 18, 2016: Blood
https://www.readbyqxmd.com/read/27357811/low-levels-of-tgf-%C3%AE-1%C3%A2-enhance-human-umbilical-cord-derived-mesenchymal-stem-cell-fibronectin-production-and-extend-survival-time-in-a-rat-model-of-lipopolysaccharide-induced-acute-lung-injury
#12
Dong Li, Qingshen Liu, Lei Qi, Xiaoyu Dai, Huan Liu, Yunshan Wang
Mesenchymal stem cells (MSCs) are an attractive cellular source for cell‑based therapy, tissue engineering and regenerative medicine. However, the use of MSCs is limited by their low incorporation rate in the graft environment. The majority of cells are lost from the graft within 1 month, due to reduced microenvironment or local inflammation at the graft site. The extracellular matrix (ECM) may assist the survival and expansion of MSCs. The present study aimed to identify an effective approach to increase ECM expression levels by MSCs in order to enhance the therapeutic effect and survival rate of MSCs at the injury site...
August 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27280283/preclinical-studies-of-mesenchymal-stem-cell-msc-administration-in-chronic-obstructive-pulmonary-disease-copd-a-systematic-review-and-meta-analysis
#13
Xiangde Liu, Qiuhong Fang, Huijung Kim
BACKGROUND: In the last two decades, mesenchymal stem cells (MSCs) have been pre-clinically utilized in the treatment of a variety of kinds of diseases including chronic obstructive pulmonary disease (COPD). The aim of the current study was to systematically review and conduct a meta-analysis on the published pre-clinical studies of MSC administration in the treatment of COPD in animal models. METHODS AND RESULTS: A systematic search of electronic databases was performed...
2016: PloS One
https://www.readbyqxmd.com/read/27244692/human-amniotic-fluid-stem-cells-labeled-with-up-conversion-nanoparticles-for-imaging-monitored-repairing-of-acute-lung-injury
#14
Yunyun Xu, Jian Xiang, He Zhao, Hansi Liang, Jie Huang, Yan Li, Jian Pan, Huiting Zhou, Xueguang Zhang, Jiang Huai Wang, Zhuang Liu, Jian Wang
Human amniotic fluid stem (hAFS) cells have generated a great deal of excitement in cell-based therapies and regenerative medicine. Here, we examined the effect of hAFS cells labeled with dual-polymer-coated UCNP-PEG-PEI nanoparticles in a murine model of acute lung injury (ALI). We observed hAFS cells migration to the lung using highly sensitive in vivo upconversion luminescence (UCL) imaging. We demonstrated that hAFS cells remained viable and retained their ability to differentiate even after UCNP-PEG-PEI labeling...
September 2016: Biomaterials
https://www.readbyqxmd.com/read/27212445/mustard-vesicant-induced-lung-injury-advances-in-therapy
#15
REVIEW
Barry Weinberger, Rama Malaviya, Vasanthi R Sunil, Alessandro Venosa, Diane E Heck, Jeffrey D Laskin, Debra L Laskin
Most mortality and morbidity following exposure to vesicants such as sulfur mustard is due to pulmonary toxicity. Acute injury is characterized by epithelial detachment and necrosis in the pharynx, trachea and bronchioles, while long-term consequences include fibrosis and, in some instances, cancer. Current therapies to treat mustard poisoning are primarily palliative and do not target underlying pathophysiologic mechanisms. New knowledge about vesicant-induced pulmonary disease pathogenesis has led to the identification of potentially efficacious strategies to reduce injury by targeting inflammatory cells and mediators including reactive oxygen and nitrogen species, proteases and proinflammatory/cytotoxic cytokines...
August 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27158855/e-prostanoid-2-receptor-overexpression-promotes-mesenchymal-stem-cell-attenuated-lung-injury
#16
Jibin Han, Xiaomin Lu, Lijuan Zou, Xiuping Xu, Haibo Qiu
Mesenchymal stem cells (MSCs) represent a promising approach for the treatment of acute respiratory distress syndrome (ARDS). However, their low efficiency in homing to injured lung tissue limits their therapeutic effect. Prostaglandin E2 (PGE2) biosynthesis substantially enhances the inflammatory response of the tissue. Moreover, it also facilitates the migration of MSCs by activating the E-prostanoid 2 (EP2) receptor in vitro. Given these observations, it would seem reasonable that PGE2 might act as a chemokine to promote the migration of MSCs through activation of the EP2 receptor...
August 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27155584/proteome-profiling-in-lung-injury-after-hematopoietic-stem-cell-transplantation
#17
Maneesh Bhargava, Kevin J Viken, Sanjoy Dey, Michael S Steinbach, Baolin Wu, Pratik D Jagtap, LeeAnn Higgins, Angela Panoskaltsis-Mortari, Daniel J Weisdorf, Vipin Kumar, Mukta Arora, Peter B Bitterman, David H Ingbar, Chris H Wendt
Pulmonary complications due to infection and idiopathic pneumonia syndrome (IPS), a noninfectious lung injury in hematopoietic stem cell transplant (HSCT) recipients, are frequent causes of transplantation-related mortality and morbidity. Our objective was to characterize the global bronchoalveolar lavage fluid (BALF) protein expression of IPS to identify proteins and pathways that differentiate IPS from infectious lung injury after HSCT. We studied 30 BALF samples from patients who developed lung injury within 180 days of HSCT or cellular therapy transfusion (natural killer cell transfusion)...
August 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27075767/combined-therapy-with-adipose-derived-mesenchymal-stem-cells-and-ciprofloxacin-against-acute-urogenital-organ-damage-in-rat-sepsis-syndrome-induced-by-intrapelvic-injection-of-cecal-bacteria
#18
Pei-Hsun Sung, Hsin-Ju Chiang, Chih-Hung Chen, Yi-Ling Chen, Tien-Hung Huang, Yen-Yi Zhen, Meng-Wei Chang, Chu-Feng Liu, Sheng-Ying Chung, Yung-Lung Chen, Han-Tan Chai, Cheuk-Kwan Sun, Hon-Kan Yip
UNLABELLED: We hypothesized that combined treatment with autologous adipose-derived mesenchymal stem cell (ADMSC) and ciprofloxacin is superior to ciprofloxacin only in reducing sepsis-induced urogenital organ damage and mortality in rat sepsis syndrome (SS) caused by intrapelvic injection of cecal bacteria (1.0 × 10(4) cells per milliliter; total, 5.0 ml). Male Sprague-Dawley rats (n = 60) equally divided into group 1 (sham-control), group 2 (SS), group 3 (SS-ADMSC [5.0 × 10(5) intravenously at 0...
June 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27055225/inhibition-of-src-and-forkhead-box-o1-signaling-by-induced-pluripotent-stem-cell-therapy-attenuates-hyperoxia-augmented-ventilator-induced-diaphragm-dysfunction
#19
Li-Fu Li, Yuh-Lih Chang, Ning-Hung Chen, Chien-Ying Wang, Gwo-Jyh Chang, Meng-Chih Lin, Chih-Hao Chang, Chung-Chi Huang, Jen-Hua Chuang, Yi-Pin Yang, Shih-Hwa Chiou, Yung-Yang Liu
Mechanical ventilation (MV) with hyperoxia is required for providing life support to patients with acute lung injury (ALI). However, MV may cause diaphragm weakness through muscle injury and atrophy, an effect termed ventilator-induced diaphragm dysfunction (VIDD). Src protein tyrosine kinase and class O of forkhead box 1 (FoxO1) mediate acute inflammatory responses and muscle protein degradation induced by oxidative stress. Induced pluripotent stem cells (iPSCs) have been reported to improve hyperoxia-augmented ALI; however, the mechanisms regulating the interactions among VIDD, hyperoxia, and iPSCs are unclear...
July 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27044826/the-protective-effects-of-bone-marrow-derived-mesenchymal-stem-cell-bmsc-on-lps-induced-acute-lung-injury-via-tlr3-mediated-ifns-mapk-and-nf-%C3%AE%C2%BAb-signaling-pathways
#20
Jingcai Wang, Ying Qin, Xiuju Mi
The study attempted to clarify the protective role of bone marrow-derived mesenchymal stem cell (BMSC) transplantation on LPS-induced acute lung injury (ALI) of rats. BMSC were obtained from bone marrow of rat, cultured and proliferated in vitro. Rats of ALI were established through lipopolysaccharide (LPS) administration. Male rats were allocated to control group, ALI group and BMSC, transplantation group. Rats were sacrificed after BMSC injection after 12h, 24h and 48h. Here we investigated the role of BMSC in LPS-induced alveolar macrophages to further demonstrate the mechanism of BMSC to lung injury...
April 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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