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stem cell therapy for ALI

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https://www.readbyqxmd.com/read/27878763/enhancement-of-neural-stem-cell-survival-proliferation-migration-and-differentiation-in-a-novel-self-assembly-peptide-nanofibber-scaffold
#1
Sajad Sahab Negah, Zabihollah Khaksar, Hadi Aligholi, Shahin Mohammad Sadeghi, Sayed Mostafa Modarres Mousavi, Hadi Kazemi, Ali Jahanbazi Jahan-Abad, Ali Gorji
Considerable efforts have been made to combine biologically active molecules into the self-assembling peptide in order to improve cells growth, survival, and differentiation. In this study, a novel three-dimensional scaffold (RADA4GGSIKVAV; R-GSIK) was designed by adding glycine and serine between RADA4 and IKVAV to promote the strength of the peptide. The cell adhesion, viability, proliferation, migration, and differentiation of rat embryonic neural stem cells (NSCs) in R-GSIK were investigated and compared to laminin-coated, two-dimensional, and Puramatrix cultures...
November 23, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27873515/angiopoietin-1-modified-human-umbilical-cord-mesenchymal-stem-cell-therapy-for-endotoxin-induced-acute-lung-injury-in-rats
#2
Zhi Wei Huang, Ning Liu, Dong Li, Hai Yan Zhang, Ying Wang, Yi Liu, Le Ling Zhang, Xiu Li Ju
PURPOSE: Angiopoietin-1 (Ang1) is a critical factor for vascular stabilization and endothelial survival via inhibition of endothelial permeability and leukocyte- endothelium interactions. Hence, we hypothesized that treatment with umbilical cord mesenchymal stem cells (UCMSCs) carrying the Ang1 gene (UCMSCs-Ang1) might be a potential approach for acute lung injury (ALI) induced by lipopolysaccharide (LPS). MATERIALS AND METHODS: UCMSCs with or without transfection with the human Ang1 gene were delivered intravenously into rats one hour after intra-abdominal instillation of LPS to induce ALI...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27865908/oleic-acid-promotes-the-expression-of-neural-markers-in-differentiated-human-endometrial-stem-cells
#3
Maryam Ali Mohammadie Kojour, Somayeh Ebrahimi-Barough, Homa Mohseni Kouchesfehani, Hanieh Jalali, Mohammah Hosein Karbalaie Ebrahim
Variety of neurodegenerative diseases in humans are caused by loss of cells along with loss of function and disability. Cell replacement therapy is a potential strategy to cure neurodegenerative diseases. Mesenchymal stem cells are pluripotent non-hematopoietic cells that can be isolated from numerous tissues. Human endometrial-derived stem cell (hEnSC) are the abundant and easy available source with no immunological response, for cell replacement therapy. In the nervous system, where fatty acids are found in huge amounts, they participate in its development and maintenance throughout life...
November 16, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27831631/stem-cells-differentiation-and-probing-their-therapeutic-applications-in-hematological-disorders-a-critical-review
#4
F Ali, S Taresh, M Al-Nuzaily, P L Mok, A Ismail, S Ahmad
Numerous lines of evidence support that bone marrow is a rich source of stem cells that can be used for research purposes and to treat some complex blood diseases and cancers. Stem cells are a potential source for regenerative medicine and tissue replacement after injury or disease, and mother cells that possess the capacity to become any type of cell in the body. They are cells without specific structure and characterized by their ability to self-renew or multiply while maintaining the potential to develop into other types of cells...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27780147/stem-cell-therapies-for-congenital-heart-disease
#5
REVIEW
Masoumeh Ghafarzadeh, Mehrdad Namdari, Ali Eatemadi
Congenital heart disease (CHD) is the most prevalent congenital anomaly in newborn babies. Cardiac malformations have been induced in different animal model experiments, by perturbing some molecules that take part in the developmental pathways associated with myocyte differentiation, specification, or cardiac morphogenesis. The exact epigenetic, environmental, or genetic, basis for these molecules perturbations is yet to be understood. But, scientist have bridged this gap by introducing autologous stem cell into the defective hearts to treat CHD...
October 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27775079/cd133-brain-tumor-initiating-cells-are-dependent-on-stat3-signaling-to-drive-medulloblastoma-recurrence
#6
N Garg, D Bakhshinyan, C Venugopal, S Mahendram, D A Rosa, T Vijayakumar, B Manoranjan, R Hallett, N McFarlane, K H Delaney, J M Kwiecien, C C Arpin, P-S Lai, R F Gómez-Biagi, A M Ali, E D de Araujo, O A Ajani, J A Hassell, P T Gunning, S K Singh
Medulloblastoma (MB), the most common malignant paediatric brain tumor, is currently treated using a combination of surgery, craniospinal radiotherapy and chemotherapy. Owing to MB stem cells (MBSCs), a subset of MB patients remains untreatable despite standard therapy. CD133 is used to identify MBSCs although its functional role in tumorigenesis has yet to be determined. In this work, we showed enrichment of CD133 in Group 3 MB is associated with increased rate of metastasis and poor clinical outcome. The signal transducers and activators of transcription-3 (STAT3) pathway are selectively activated in CD133(+) MBSCs and promote tumorigenesis through regulation of c-MYC, a key genetic driver of Group 3 MB...
October 24, 2016: Oncogene
https://www.readbyqxmd.com/read/27766946/in-vitro-models-of-cancer-stem-cells-and-clinical-applications
#7
Sara S Franco, Karolina Szczesna, Maria S Iliou, Mohammed Al-Qahtani, Ali Mobasheri, Julianna Kobolák, András Dinnyés
Cancer cells, stem cells and cancer stem cells have for a long time played a significant role in the biomedical sciences. Though cancer therapy is more effective than it was a few years ago, the truth is that still none of the current non-surgical treatments can cure cancer effectively. The reason could be due to the subpopulation called "cancer stem cells" (CSCs), being defined as those cells within a tumour that have properties of stem cells: self-renewal and the ability for differentiation into multiple cell types that occur in tumours...
September 30, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27747732/accidental-overdose-of-oral-cyclosporine-in-haematopoietic-stem-cell-transplantation-a-case-report-and-literature-review
#8
Ali Tafazoli
A 26-year-old woman developed symptoms of acute toxicity during cyclosporine (CsA) therapy for graft-versus-host disease prophylaxis. The standard regimen included CsA in a dose of 1.5 mg/kg (120 mg) every 12 h, but, as a medication error, she received a high dose of 500 mg of oral CsA. After 2 h, she developed nausea and vomiting and, subsequently, flushing, chest tightness, tremor and vertigo. Laboratory and clinical examinations revealed high blood CsA concentrations (1000 ng/mL after 12 h) with a mild increase in blood pressure...
December 2015: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27703531/lithium-chloride-has-a-biphasic-effect-on-prostate-cancer-stem-cells-and-a-proportional-effect-on-midkine-levels
#9
Mine Erguven, Gulperi Oktem, Ali Nail Kara, Ayhan Bilir
Prostate cancer (PCa) is the second most frequent type of cancer in men worldwide and the levels of differentiation growth factor midkine (MK) are increased in PCa. Cancer and/or the treatment process itself may lead to psychiatric disorders. Lithium chloride (LiCl) has anti-manic properties and has been used in cancer therapy; however, it has a queried safety profile. In addition, cancer stem cells are responsible for the heterogeneous phenotype of tumor cells; they are involved in progression, metastasis, recurrence and therapy resistance in various cancer types...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27699025/allogeneic-stem-cell-transplantation-in-a-blast-phase-chronic-myeloid-leukemia-patient-with-carbapenem-resistant-klebsiella-pneumoniae-tricuspid-valve-endocarditis-a-case-report
#10
Bulent Kantarcioglu, Huseyin Saffet Bekoz, Fatih Erkam Olgun, Beytullah Cakal, Burak Arkan, Halil Turkoglu, Ali Mert, Deniz Sargin
In chronic myeloid leukemia (CML), the occurrence of blastic transformation is rare. Treatment outcome is generally poor. Allogeneic stem cell transplantation (allo-SCT) is the only potentially curative treatment option for advanced-phase CML. Infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates are associated with high morbidity and mortality rates, particularly in patients with haematological malignancies. Infection and colonization by these multiresistant bacteria may represent a challenge in SCT recipients for the management of post-transplantation complications, as well as for the eligibility to receive a transplant in patients who acquire the pathogen prior to the procedure...
October 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27694285/tumor-cancer-stem-cell-marker-doublecortin-like-kinase-1-in-liver-diseases
#11
Charles B Nguyen, Courtney W Houchen, Naushad Ali
Liver diseases are the fourth leading cause of mortality among adults in the United States. Patients with chronic liver diseases such as viral hepatitis, fibrosis, and cirrhosis have significantly higher risks of developing hepatocellular carcinoma (HCC). With a dismal five-year survival rate of 11%, HCC is the third most common cause of cancer-related deaths worldwide. Regardless of the underlying cause, late presentation and a lack of effective therapy are the major impediments for successful treatment of HCC...
September 30, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27644345/evidence-that-bone-marrow-derived-mesenchymal-stem-cells-reduce-epithelial-permeability-following-phosgene-induced-acute-lung-injury-via-activation-of-wnt3a-protein-induced-canonical-wnt-%C3%AE-catenin-signaling
#12
Jing Zhang, Yiru Shao, Daikun He, Lin Zhang, Guoxiong Xu, Jie Shen
: An increase in epithelial cell permeability has been proposed to contribute to phosgene-induced acute lung injury (ALI). However, no specific and effective means for blocking increases in permeability are currently available. Cell-based therapy using bone marrow-derived mesenchymal stem cells (MSCs) is an attractive new approach. Canonical wnt/β-catenin signaling has been demonstrated to contribute to both epithelial cell injury and repair mechanisms in ALI. The goal of our study was to determine the effects of MSCs on epithelial permeability in phosgene-induced ALI in Sprague-Dawley (SD) rats and identify changes in major components of the wnt3a/β-catenin signaling pathway during this process...
October 2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/27604747/a-novel-biopsy-method-for-isolating-neural-stem-cells-from-the-subventricular-zone-of-the-adult-rat-brain-for-autologous-transplantation-in-cns-injuries
#13
Hadi Aligholi, Gholamreza Hassanzadeh, Ali Gorji, Hassan Azari
Despite all attempts the problem of regeneration in damaged central nervous system (CNS) has remained challenging due to its cellular complexity and highly organized and sophisticated connections. In this regard, stem cell therapy might serve as a viable therapeutic approach aiming either to support the damaged tissue and hence to reduce the subsequent neurological dysfunctions and impairments or to replace the lost cells and re-establish damaged circuitries. Adult neural stem/progenitor cells (NS/PCs) are one of the outstanding cell sources that can be isolated from the subventricular zone (SVZ) of the lateral ventricles...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27603913/cancer-testis-antigens-expression-regulation-tumor-invasion-and-use-in-immunotherapy-of-cancers
#14
Arash Salmaninejad, Mohammad Reza Zamani, Mehrnaz Pourvahedi, Zahra Golchehre, Ali Hosseini Bereshneh, Nima Rezaei
UNLABELLED: Cancer/testis antigens (CTAs) are named based on their expression pattern that is restricted in a number of normal and abnormal tissues. Tumor cells frequently express antigens whose expression is typically restricted to germ cells. Their unique expression pattern is guaranteed by precise epigenetic regulatory mechanisms. Because of their tumor-limited, high immunogenicity, and biased expression, discovery of these molecules provides unprecedented opportunities for further research and clinical development in the field of cancer diagnosis and immunotherapy...
October 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27576370/one-year-results-from-a-prospective-randomized-trial-comparing-phlebotomy-with-deferasirox-for-the-treatment-of-iron-overload-in-pediatric-patients-with-thalassemia-major-following-curative-stem-cell-transplantation
#15
Adlette Inati, Mario Kahale, Nada Sbeiti, Maria Domenica Cappellini, Ali T Taher, Suzanne Koussa, Therese A Nasr, Khaled M Musallam, Hussein A Abbas, John B Porter
BACKGROUND: Iron overload is well documented in patients with β-thalassemia major, and patients who have undergone hematopoietic stem cell transplantation (HSCT) remain at risk as a result of pre- and immediate post-HSCT transfusions. PROCEDURE: This is a prospective, randomized, 1-year clinical trial that compares the efficacy and safety of the once-daily oral iron chelator deferasirox versus phlebotomy for the treatment of iron overload in children with β-thalassemia major following HSCT...
August 31, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27569297/ebv-positive-mucocutaneous-ulcer-arising-in-a-post-hematopoietic-cell-transplant-patient-followed-by-polymorphic-post-transplant-lymphoproliferative-disorder-and-cytomegalovirus-colitis
#16
Akira Satou, Akio Kohno, Ryuichi Fukuyama, Ahmed Ali Elsayed, Shigeo Nakamura
Epstein-Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) is a newly described entity occurring in elderly or iatrogenically immunocompromised patients. We describe a case of EBVMCU arising in a post-hematopoietic cell transplant patient, and followed by EBV-positive polymorphic post-transplant lymphoproliferative disorder (EBV(+) polymorphic PTLD). The patient, a 52-year-old woman, received chemotherapy and autologous peripheral blood stem cell transplantation (auto-PBSCT) for relapsed diffuse large B-cell lymphoma (DLBCL)...
August 25, 2016: Human Pathology
https://www.readbyqxmd.com/read/27561758/targeting-cancer-stem-cell-specific-markers-and-or-associated-signaling-pathways-for-overcoming-cancer-drug-resistance
#17
Peyman Ranji, Tayyebali Salmani Kesejini, Sara Saeedikhoo, Ali Mohammad Alizadeh
Cancer stem cells (CSCs) are a small subpopulation of tumor cells with capabilities of self-renewal, dedifferentiation, tumorigenicity, and inherent chemo-and-radio therapy resistance. Tumor resistance is believed to be caused by CSCs that are intrinsically challenging to common treatments. A number of CSC markers including CD44, CD133, receptor tyrosine kinase, aldehyde dehydrogenases, epithelial cell adhesion molecule/epithelial specific antigen, and ATP-binding cassette subfamily G member 2 have been proved as the useful targets for defining CSC population in solid tumors...
August 26, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27559438/transplantation-of-neural-stem-cells-cultured-in-alginate-scaffold-for-spinal-cord-injury-in-rats
#18
Seyed Mojtaba Hosseini, Ali Sharafkhah, Omid Koohi-Hosseinabadi, Maryam Semsar-Kazerooni
STUDY DESIGN: This study investigated the effects of transplantation of alginate encapsulated neural stem cells (NSCs) on spinal cord injury in Sprague-Dawley male rats. The neurological functions were assessed for 6 weeks after transplantation along with a histological study and measurement of caspase-3 levels. PURPOSE: The aim of this study was to discover whether NSCs cultured in alginate transplantation improve recovery from spinal cord injury. OVERVIEW OF LITERATURE: Spinal cord injury is one of the leading causes of disability and it has no effective treatment...
August 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27539657/systemic-administration-of-cell-free-exosomes-generated-by-human-bone-marrow-derived-mesenchymal-stem-cells-cultured-under-2d-and-3d-conditions-improves-functional-recovery-in-rats-after-traumatic-brain-injury
#19
Yanlu Zhang, Michael Chopp, Zheng Gang Zhang, Mark Katakowski, Hongqi Xin, Changsheng Qu, Meser Ali, Asim Mahmood, Ye Xiong
Multipotent human bone marrow derived mesenchymal stem cells (hMSCs) improve functional outcome after experimental traumatic brain injury (TBI). The present study was designed to investigate whether systemic administration of cell-free exosomes generated from hMSCs cultured in 2-dimensional (2D) conventional conditions or in 3-dimensional (3D) collagen scaffolds promote functional recovery and neurovascular remodeling in rats after TBI. Wistar rats were subjected to TBI induced by controlled cortical impact; 24 h later tail vein injection of exosomes derived from hMSCs cultured under 2D or 3D conditions or an equal number of liposomes as a treatment control were performed...
August 15, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27536714/datasets-of-a-novel-bivalent-single-chain-antibody-constructed-by-overlapping-oligonucleotide-annealing-method-targeting-human-cd123
#20
Shima Moradi-Kalbolandi, Mahdi Habibi-Anbouhi, Majid Golkar, Mahdi Behdani, Gashin Rezaei, Leila Ghazizadeh, Mohsen Abolhassani, Mohammad Ali Shokrgozar
Current therapies for acute myeloid leukemia (AML), are associated with high relapse rates. Hence, development of new therapeutic strategies is crucial to circumvent this problem. Bivalent antibody technology has been used to engineer novel antibody fragments with increased avidity, by assembling two scFv in a single molecule. Here, we present accompanying data from construction and characterization experiments of a biscFv antibody targeting CD123, the most important biomarker of leukemic cancer stem cells which play a key role in relapsed AML after chemotherapy...
September 2016: Data in Brief
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