keyword
MENU ▼
Read by QxMD icon Read
search

Physostigmine

keyword
https://www.readbyqxmd.com/read/29628850/development-of-postoperative-central-anticholinergic-syndrome-due-to-low-dose-intravenous-fentanyl
#1
Hojae Cho, Jiyeon Kim
A 37-year-old female patient, 57 kg and 160 cm, underwent laparoscopic appendectomy. In the recovery room, fentanyl 100 mcg was intravenously administered for pain control. Three minutes after the administration, the patient developed intense and uncontrolled myoclonus, lower limb rigidity, agitation, aphasia, and periocular and neck swelling. The myoclonus and rigidity were suspected to be due to the opioid administration, and thus, naloxone was administered, but the symptoms were not improved. The patient's symptoms continued until the patient received administration of physostigmine...
April 2018: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/29589284/hypoxia-induced-neuroinflammation-and-learning-memory-impairments-in-adult-zebrafish-are-suppressed-by-glucosamine
#2
Yunkyoung Lee, Sujeong Lee, Ji-Won Park, Ji-Sun Hwang, Sang-Min Kim, In Kyoon Lyoo, Chang-Joong Lee, Inn-Oc Han
This study investigated changes in neuroinflammation and cognitive function in adult zebrafish exposed to acute hypoxia and protective effects of glucosamine (GlcN) against hypoxia-induced brain damage. The survival rate of zebrafish following exposure to hypoxia was improved by GlcN pretreatment. Moreover, hypoxia-induced upregulation of neuroglobin, NOS2α, glial fibrillary acidic protein, and S100β in zebrafish was suppressed by GlcN. Hypoxia stimulated cell proliferation in the telencephalic ventral domain and in cerebellum subregions...
March 27, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29553158/cholinergic-medication-for-antipsychotic-induced-tardive-dyskinesia
#3
REVIEW
Irina Tammenmaa-Aho, Rosie Asher, Karla Soares-Weiser, Hanna Bergman
BACKGROUND: Tardive dyskinesia (TD) remains a troublesome adverse effect of conventional antipsychotic (neuroleptic) medication. It has been proposed that TD could have a component of central cholinergic deficiency. Cholinergic drugs have been used to treat TD. OBJECTIVES: To determine the effects of cholinergic drugs (arecoline, choline, deanol, lecithin, meclofenoxate, physostigmine, RS 86, tacrine, metoxytacrine, galantamine, ipidacrine, donepezil, rivastigmine, eptastigmine, metrifonate, xanomeline, cevimeline) for treating antipsychotic-induced TD in people with schizophrenia or other chronic mental illness...
March 19, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29501509/enhanced-cholinergic-tone-during-the-stress-induce-a-depressive-like-state-in-mice
#4
Sara S Fernandes, André P Koth, Gustavo M Parfitt, Marcos F Cordeiro, Carolina S Peixoto, Andréa Soubhia, Fernanda P Moreira, Carolina D Wiener, Jean P Oses, Erikson Kaszubowski, Daniela M Barros
Major depressive disorder has a heterogeneous etiology, since it arises from the interaction of multiple factors and different pathophysiological mechanisms are involved in the symptomatology. This study aimed to investigate the role of the cholinergic system in the susceptibility to stress and, consequently, in the depression-like behavior. C57BL/6 mice were treated with Physostigmine (PHYS), an acetylcholinesterase (AChE) inhibitor, and were submitted to the social defeat stress. For the behavioral evaluation of the locomotor activity, anxiety-like and depression-like behaviors the open field, elevated plus maze, sucrose preference, social interaction and forced swim were used...
March 1, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29490506/safety-and-effectiveness-of-physostigmine-seeing-the-trees-for-the-forest-plot
#5
Michael E Mullins, Evan S Schwarz
No abstract text is available yet for this article.
February 28, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29472646/interaction-between-noradrenergic-and-cholinergic-signaling-in-amygdala-regulates-anxiety-and-depression-related-behaviors-in-mice
#6
Yann S Mineur, Emma L Cahuzac, Tenna N Mose, Matthew P Bentham, Margreet E Plantenga, David C Thompson, Marina R Picciotto
Medications that target the noradrenergic system are important therapeutics for depression and anxiety disorders. More recently, clinical studies have shown that the α2-noradrenergic receptor (α2AR) agonist guanfacine can decrease stress-induced smoking relapse during acute abstinence, suggesting that targeting the noradrenergic system may aid in smoking cessation through effects on stress pathways in the brain. Acetylcholine (ACh), like the nicotine in tobacco, acts at nicotinic acetylcholine receptors (nAChRs) to regulate behaviors related to anxiety and depression...
February 22, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29436790/cromakalim-a-potassium-channel-opener-ameliorates-the-organophosphate-and-carbamate-induced-seizure-in-mice
#7
Sattar Ostadhadi, Abouzar Moradi, Samira Zolfaghari, Vahid Nikoui, Ahmad Reza Dehpour
Organophosphates (OPs) and carbamates are acetylcholine esterase inhibitors (AChEIs), which can cause seizure and lethality. Anticonvulsant properties of potassium channel openers including cromakalim have been determined in previous studies. In the present experiment, the possible effect of cromakalim on the convulsion and death induced by OPs and carbamates was studied in mice. Dichlorvos (an OP, 50 mg/kg) and physostigmine (a carbamate, 2 mg/kg) were used to induce seizure in animals. Cromakalim at doses of 0...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29369803/inhibitory-modulation-of-the-cough-reflex-by-acetylcholine-in-the-caudal-nucleus-tractus-solitarii-of-the-rabbit
#8
Elenia Cinelli, Ludovica Iovino, Fulvia Bongianni, Tito Pantaleo, Donatella Mutolo
A cholinergic system has been described in the nucleus tractus solitarii (NTS). However, no information is available on the role played by acetylcholine (ACh) in the modulation of the cough reflex within the caudal NTS that has an important function in cough regulation. We addressed this issue making use of bilateral microinjections (30-50 nl) of 10 mM ACh combined with 5 mM physostigmine as well as of 10 mM mecamylamine or 10 mM scopolamine into the caudal NTS of pentobarbital sodium-anesthetized, spontaneously breathing rabbits...
January 21, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29353174/cholinesterase-activity-in-the-cup-oyster-saccostrea-sp-exposed-to-chlorpyrifos-imidacloprid-cadmium-and-copper
#9
Angela M Moncaleano-Niño, Andrea Luna-Acosta, Maria Camila Gómez-Cubillos, Luisa Villamil, Michael J Ahrens
In the present study, the sensitivity and concentration dependence of three functionally-defined components of cholinesterase activity (total: T-ChE; eserine-sensitive: Es-ChE; and eserine-resistant: Er-ChE) were quantified in the gill, digestive gland and adductor muscle of the tropical cup oyster Saccostrea sp., following acute (96h) aqueous exposure to commercial formulations of the organophosphate (OP) insecticide chlorpyrifos and the neonicotinoid (NN) imidacloprid (concentration range: 0.1-100mg/L), as well as to dissolved cadmium and copper (concentration range: 1-1000μg/L)...
April 30, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29248451/features-and-outcomes-of-drugs-for-combination-therapy-as-multi-targets-strategy-to-combat-alzheimer-s-disease
#10
REVIEW
Atish Kumar Sahoo, Jagnehswar Dandapat, Umesh Chandra Dash, Satish Kanhar
ETHNOPHARMACOLOGICAL RELEVANCE: Alzheimer's disease (AD), a deleterious neurodegenerative disorder that impairs memory, cognitive functions and may lead to dementia in late stage of life. The pathogenic cause of AD remains incompletely understood and FDA approved drugs are partial inhibitors rather than curative. Most of drugs are synthetic or natural products as galanthamine is an alkaloid obtained from Galanthus spp. Huperzine A, an alkaloid found in Huperzia spp., gingkolides a diterpenoids from Gingko biloba and many ethnobotanicals like Withania somnifera (L...
April 6, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29236828/mary-broadfoot-walker-83-years-since-a-historical-discovery
#11
Vitor Martinez de Carvalho, Eduardo de Almeida Guimarães Nogueira, Gleysson Rodrigues Rosa, Yara Dadalti Fragoso
Mary Broadfoot Walker was a Scottish physician who, in 1935, described in great detail the effect of an anticholinesterase drug (physostigmine) on the signs and symptoms of myasthenia gravis. An original five-minutes movie is available online and the skepticism of her contemporary British medical doctors is understandable when the drastic effect of the treatment is shown in this movie. What Mary Walker taught us, more than eight decades ago, about myasthenia gravis continues to be the basis of a pharmacological diagnostic test and treatment of this disease...
November 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29173156/identification-of-human-acetylcholine-esterase-inhibitors-from-the-constituents-of-egb761-by-modeling-docking-and-molecular-dynamics-simulations
#12
Lihu Zhang, Dongdong Li, Fuliang Cao, Wei Xiao, Linguo Zhao, Zhenzhong Wang, Gang Ding
EGb761, a standardized and well-defined product extract of Ginkgo biloba leaves, has beneficial effects on the treatment of multiple diseases, particularly Alzheimer's disease (AD). Identification of natural acetylcholine esterase (AChE) inhibitors from EGb761 would provide a novel therapeutic approach against the Alzheimer's disease. A series of 21 kinds of promising EGB761 compounds were selected, and subsequently evaluated for their potential ability to bind AChE enzyme by molecular docking and a deep analysis of protein surface pocket features...
November 23, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/29167930/planarian-cholinesterase-molecular-and-functional-characterization-of-an-evolutionarily-ancient-enzyme-to-study-organophosphorus-pesticide-toxicity
#13
Danielle Hagstrom, Siqi Zhang, Alicia Ho, Eileen S Tsai, Zoran Radić, Aryo Jahromi, Kelson J Kaj, Yingtian He, Palmer Taylor, Eva-Maria S Collins
The asexual freshwater planarian Dugesia japonica has emerged as a medium-throughput alternative animal model for neurotoxicology. We have previously shown that D. japonica are sensitive to organophosphorus pesticides (OPs) and characterized the in vitro inhibition profile of planarian cholinesterase (DjChE) activity using irreversible and reversible inhibitors. We found that DjChE has intermediate features of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Here, we identify two candidate genes (Djche1 and Djche2) responsible for DjChE activity...
November 22, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29136766/behavioral-and-biochemical-evidences-for-nootropic-activity-of-boldine-in-young-and-aged-mice
#14
Dinesh Dhingra, Kapil Soni
Boldine, a bioactive compound, has been reported to be neuroprotective, but its effect on learning and memory has not been explored. So, the present study was aimed to study the effect of boldine on the learning and memory of the Swiss albino male young and aged mice. Boldine (1.5, 3 and 6mg/kg, po) and physostigmine salicylate (0.1mg/kg, ip) were administered to separate groups of mice for 7 successive days. Morris water maze was utilized as a behavioural model to study the effect of drugs on learning and memory of mice...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29126416/adjunctive-use-of-physostigmine-salicylate-anticholium%C3%A2-in-perioperative-sepsis-and-septic-shock-study-protocol-for-a-randomized-double-blind-placebo-controlled-monocentric-trial-anticholium%C3%A2-per-se
#15
Johannes B Zimmermann, Nadine Pinder, Thomas Bruckner, Monika Lehmann, Johann Motsch, Thorsten Brenner, Torsten Hoppe-Tichy, Stefanie Swoboda, Markus A Weigand, Stefan Hofer
BACKGROUND: Severe sepsis and septic shock remain a major challenge, even in modern intensive care. In Germany, about 68,000 patients die annually because of septic diseases, characterized by a complex systemic inflammatory response. Causal treatment of the underlying infection is essential for successful management of sepsis, but the course can be positively influenced by supportive and adjuvant measures. The cholinergic anti-inflammatory pathway (CAP) represents a new approach to adjunctive therapy of septic diseases and can be pharmacologically activated by the acetylcholinesterase inhibitor physostigmine (Anticholium®)...
November 10, 2017: Trials
https://www.readbyqxmd.com/read/29122691/sexually-diergic-hypothalamic-pituitary-adrenal-axis-responses-to-selective-and-non-selective-muscarinic-antagonists-prior-to-cholinergic-stimulation-by-physostigmine-in-rats
#16
Marissa A Smail, Jessica L Soles, Tracy E Karwoski, Robert T Rubin, Michael E Rhodes
Central cholinergic systems regulate the hypothalamic-pituitary-adrenal (HPA) axis differentially in males and females (sexual diergism). We previously investigated the role of muscarinic receptors in this regulation by administering physostigmine (PHYSO), an acetylcholinesterase inhibitor, to male and female rats pretreated with scopolamine (SCOP), a nonselective muscarinic antagonist. SCOP pretreatment enhanced adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses in both sexes, but males had greater ACTH responses while females had greater CORT responses...
November 7, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29119218/odor-cueing-during-slow-wave-sleep-benefits-memory-independently-of-low-cholinergic-tone
#17
Jens G Klinzing, Sabine Kugler, Surjo R Soekadar, Björn Rasch, Jan Born, Susanne Diekelmann
RATIONALE: Sleep-dependent memory consolidation depends on the concerted reactivation of memories in the hippocampo-neocortical system. The communication of reactivated information from the hippocampus to the neocortex is assumed to be enabled by low levels of acetylcholine, particularly during slow-wave sleep (SWS). Recent studies suggest that the reactivation of memories does not only occur spontaneously but can also be externally triggered by re-presenting learning-associated cues during sleep...
January 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29081821/flavonoid-composition-and-biological-activities-of-ethanol-extracts-of-caryocar-coriaceum-wittm-a-native-plant-from-caatinga-biome
#18
Daniela Ribeiro Alves, Selene Maia de Morais, Fernanda Tomiotto-Pellissier, Milena Menegazzo Miranda-Sapla, Fábio Roger Vasconcelos, Isaac Neto Goes da Silva, Halisson Araujo de Sousa, João Paulo Assolini, Ivete Conchon-Costa, Wander Rogério Pavanelli, Francisco das Chagas Oliveira Freire
Caryocar coriaceum fruits, found in Brazilian Cerrado and Caatinga, are commonly used as food and in folk medicine, as anti-inflammatory, bactericide, fungicide, leishmanicide, and nematicide. Due to the biological potential of this plant, this study focuses on the evaluation of antifungal and antileishmanial activities, including anticholinesterase and antioxidant tests, correlating with total phenols and flavonoids content. Peel extracts contain higher yield of phenols and flavonoids as analyzed by spectrophotometric methods...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29073764/retraction-of-an-expeditious-route-to-both-enantiomers-of-all-carbon-quaternary-stereocenters-at-c-3-carbon-of-lactams-via-3-3-sigmatropic-rearrangement-total-synthesis-of-physostigmine
#19
Ganesh Pandey, Jagadish Khamrai, Akash Mishra
No abstract text is available yet for this article.
November 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/28963050/seizure-susceptibility-in-the-app-ps1-mouse-model-of-alzheimer-s-disease-and-relationship-with-amyloid-%C3%AE-plaques
#20
Karen E Reyes-Marin, Angel Nuñez
Alzheimer's disease is a common age associated neurodegenerative disorder associated with an elevated risk of seizures that may be fundamentally connected to cognitive dysfunction. We used 4-9month-old mice of the APP/PS1 mouse model of Alzheimer's disease to study the presence of epileptiform-like discharges and to establish if the amyloid-β plaques affect their generation. The EEG of the APP/PS1 transgenic mice revealed a higher incidence of epileptiform-like discharges i.e. seizure events (interictal spikes, sharp waves, or polyspikes) than in the controls...
December 15, 2017: Brain Research
keyword
keyword
78645
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"