keyword
https://read.qxmd.com/read/37494577/mirabegron-and-anticholinergics-in-the-treatment-of-overactive-bladder-syndrome-a-meta-analysis
#21
JOURNAL ARTICLE
Luisa Gracio Ferreira Sartori, Bruno Monteiro Nunes, Daniela Farah, Leticia Maria de Oliveira, Claudia Cristina Takano Novoa, Marair Gracio Ferreira Sartori, Marcelo Cunio Machado Fonseca
OBJECTIVE:  To compare the use of mirabegron with anticholinergics drugs for the treatment of overactive bladder (OB). DATA SOURCE:  Systematic searches were conducted in EMBASE, PUBMED, Cochrane, and LILACS databases from inception to September 2021. We included RCTs, women with clinically proven OB symptoms, studies that compared mirabegron to antimuscarinic drugs, and that evaluated the efficacy, safety or adherence. DATA COLLECTION:  RevMan 5...
June 2023: Revista Brasileira de Ginecologia e Obstetrícia
https://read.qxmd.com/read/37490669/-an-effect-of-antipsychotic-and-anticholinergic-treatment-on-cognitive-function-in-patients-with-schizophrenia
#22
JOURNAL ARTICLE
M A Tumova, A A Stepanova, Y S Zazulina, Z T Guseinova, M M Zaitseva, I V Dyment, A P Kotsyubinsky, M V Ivanov
OBJECTIVE: To reveal the relationships between antipsychotic and anticholinergic drugs and cognitive functions in patients with schizophrenia. MATERIAL AND METHODS: The observational prospective study was conducted at the Bekhterev National Medical Center of Psychiatry and Neurology. The study involved 41 patients (22 men and 19 women) with paranoid schizophrenia, according to ICD 10 criteria, aged 30.12±8.24 years on stable antipsychotic monotherapy or in combination with anticholinergic drug (trihexiphenidyl)...
2023: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/37481288/-deliberate-intoxication-with-datura-stramonium-a-rare-cause-of-confusion
#23
JOURNAL ARTICLE
Julien Hoba, Mathilde Bordage, Philippe Chassagne, Frédéric Roca
Many drugs can be responsible for this syndrome. Although it remains rare, poisoning by Datura Stramonium should be considered in the event of anticholinergic syndrome in the elderly, particularly in the event of anticholinergic manifestations.
2023: Soins. Gérontologie
https://read.qxmd.com/read/37418037/depression-in-dementia-with-lewy-bodies-a-critical-update
#24
REVIEW
Kurt A Jellinger
Depression with an estimated prevalence of 35% is a frequent manifestation of dementia with Lewy bodies (DLB), having negative effects on cognitive performance and life expectancy, yet the underlying neurobiology is poorly understood and most likely heterogeneous. Depressive symptoms in DLB can occur during the clinical course and, together with apathy, is a common prodromal neuropsychiatric symptom of this neurocognitive disorder in the group of Lewy body synucleinopathies. There are no essential differences in the frequency of depression in DLB and Parkinson disease-dementia (PDD), while its severity is up to twice as high as in Alzheimer disease (AD)...
October 2023: Journal of Neural Transmission
https://read.qxmd.com/read/37363115/ninjin-yoeito-improves-genitourinary-symptoms-in-patients-with-frailty
#25
JOURNAL ARTICLE
Nobuo Okui, Machiko Aurora Okui
Introduction In geriatric medicine, there is currently significant attention on frailty, a condition commonly associated with aging and characterized by muscle weakness and other age-related changes. Within the fields of urology and gynecology, conditions such as overactive bladder (OAB) and genitourinary syndrome of menopause (GSM) have been identified as crucial concerns due to their negative impact on the quality of life of elderly individuals. In this study, we investigated the potential of Ninjin'yoeito (NYT), a traditional Chinese herbal medicine, as a viable treatment option for frailty...
June 2023: Curēus
https://read.qxmd.com/read/37334595/sundowning-in-patients-with-dementia-identification-prevalence-and-clinical-correlates
#26
JOURNAL ARTICLE
Marco Toccaceli Blasi, Martina Valletta, Alessandro Trebbastoni, Fabrizia D'Antonio, Giuseppina Talarico, Alessandra Campanelli, Micaela Sepe Monti, Emanuela Salati, Marina Gasparini, Simona Buscarnera, Martina Salzillo, Marco Canevelli, Giuseppe Bruno
BACKGROUND: The term sundowning is used to describe the emergence or worsening of neuropsychiatric symptoms in late afternoon or early evening in people with dementia. OBJECTIVE: Our aim was to evaluate sundowning's prevalence and clinical manifestations among patients attending a tertiary memory clinic and to investigate its clinical and neuropsychological correlates. METHODS: Patients with dementia attending our memory clinic were enrolled in the study...
June 10, 2023: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/37331921/what-are-the-short-term-benefits-and-potential-harms-of-therapeutic-modalities-for-the-management-of-overactive-bladder-syndrome-in-women-a-review-of-evidence-under-the-auspices-of-the-european-association-of-urology-female-non-neurogenic-lower-urinary-tract
#27
REVIEW
Fawzy Farag, Vasileios I Sakalis, Serenella Monagas Arteaga, Néha Sihra, Markos Karavitakis, Salvador Arlandis, Kari Bø, Hanny Cobussen-Boekhorst, Elisabetta Costantini, Monica de Heide, Jan Groen, Benoit Peyronnet, Veronique Phé, Mary-Lynne van Poelgeest-Pomfret, Tine W L van den Bos, Huub van der Vaart, Christopher K Harding, Marie Carmela Lapitan, Muhammad Imran Omar, Arjun K Nambiar
CONTEXT: Overactive bladder syndrome (OAB) is highly prevalent among women and has a negative impact on their quality of life. The current available treatments for OAB symptoms include conservative, pharmacological, or surgical modalities. OBJECTIVE: To provide an updated contemporary evidence document regarding OAB treatment options and determine the short-term effectiveness, safety, and potential harms of the available treatment modalities for women with OAB syndrome...
September 2023: European Urology
https://read.qxmd.com/read/37303428/acute-onset-achalasia-following-a-recent-covid-19-infection-a-case-report
#28
Asad Ullah Wasim, Muhammad Wasim Khan, Osama A Khan, Kholoud Soliman Almatraf
Achalasia is a rare esophageal motility disorder that leads to dysphagia, regurgitation, and several other symptoms. While the etiology of achalasia is not completely understood, studies have suggested an immune reaction to viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as a potential cause. Here, we present a case report of a previously healthy 38-year-old male who presented to the emergency room with severe shortness of breath, recurrent vomiting, and dry cough, that had progressively worsened over five days...
May 2023: Curēus
https://read.qxmd.com/read/37292046/potential-drug-drug-interactions-in-males-living-with-hiv-who-use-drugs-to-treat-lower-urinary-tract-symptoms
#29
JOURNAL ARTICLE
David Burger, Piter Oosterhof, Karin Grintjes, Manon Marneef-Pietersma, Frank d'Ancona, Xiaoye Zhu, Stephan Keijmel, Olivier Richel, Reinout van Crevel, David Jansen
OBJECTIVE: Lower urinary tract symptoms (LUTS) are becoming more prevalent in the ageing population of males living with HIV. Drugs to treat LUTS are known for both their potential role as victims in drug-drug interactions (DDIs) and their side effects. We aimed to evaluate the current use of drugs to treat LUTS and to assess potential DDIs in our cohort of adult males living with HIV. DESIGN: This was a retrospective review of pharmacy records. METHODS: We recorded the combination antiretroviral therapy (cART) regimen and any use of drugs to treat LUTS (anatomical therapeutic chemical codes G04CA/CB/CX and G04BD)...
October 2023: HIV Medicine
https://read.qxmd.com/read/37282618/eeg-changes-as-an-indication-of-central-nervous-system-involvement-following-cyclopentolate-1-eye-drops-a-randomized-placebo-controlled-pilot-study-in-a-pediatric-population
#30
JOURNAL ARTICLE
Helena Maria van Minderhout, Maurits Victor Joosse, Erica Surya Klaassen, Nicoline Elisabeth Schalij-Delfos
To compare EEG-patterns after instillation of cyclopentolate versus placebo eye drops. Prospective, randomized, placebo-controlled, and observational pilot study is presented. Ophthalmology outpatient clinic Dutch metropolitan hospital. Healthy 6- to 15-year-old volunteers with normal or low BMI requiring a cycloplegic refraction/retinoscopy. Randomized; 1 visit 2 drops cyclopentolate-1% and 1 visit 2 drops placebo (saline-0.9%). Single-blind: conducting researcher. Double blind: subjects, parents, clinical-neurophysiology staff, neurologist, and statistician...
June 6, 2023: Strabismus
https://read.qxmd.com/read/37268171/open-label-pilot-evaluation-of-the-safety-and-efficacy-of-intravesical-sustained-release-system-of-lidocaine-and-oxybutynin-trg-100-for-patients-with-interstitial-cystitis-bladder-pain-syndrome-ic-bps-overactive-bladder-oab-and-patients-with-retained-ureteral
#31
JOURNAL ARTICLE
Galiya Raisin, David Dothan, Dolev Perez, Natshe Ala-Adin, Ilan Kafka, Ofer Shenfeld, Shira Hatumi, Nadav Malchi, Avi Gordon, Dan Touitou, Robert Moldwin, Taher Nassar, Boris Chertin
OBJECTIVES: Intravesical instillation of analgesic and anticholinergic drugs have shown efficacy in the treatment of pain and voiding symptoms. Unfortunately, drug loss with urination and dilution in the bladder limit their durability and clinical usefulness. We have recently developed and tested In-Vitro, a sustained delivery system (TRG-100) of fixed-dose combination of lidocaine and oxybutynin designed to allow for a longer exposure of the urinary bladder to the drugs. This study assessed the safety and efficacy of TRG-100 in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS), overactive bladder (OAB) and endourological intervention stented (EUI) patients in an open-label, prospective study...
May 31, 2023: Urology
https://read.qxmd.com/read/37251531/-central-anticholinergic-neuroleptic-malignant-and-serotonin-syndromes
#32
REVIEW
Tobias Hölle, Jan C Purrucker, Benedict Morath, Markus A Weigand, Felix C F Schmitt
Impaired consciousness is a frequent phenomenon after general anesthesia. In addition to the classical causes (e.g., overhang of sedatives), an impairment of consciousness can also be an adverse side effect of drugs. Many drugs used in anesthesia can trigger these symptoms. Alkaloids, such as atropine can trigger a central anticholinergic syndrome, opioids can promote the occurrence of serotonin syndrome and the administration of a neuroleptic can lead to neuroleptic malignant syndrome. These three syndromes are difficult to diagnose due to the individually very heterogeneous symptoms...
2023: Wiener Klinisches Magazin: Beilage Zur Wiener Klinischen Wochenschrift
https://read.qxmd.com/read/37240596/the-investigation-of-percutaneous-tibial-nerve-stimulation-ptns-as-a-minimally-invasive-non-surgical-non-hormonal-treatment-for-overactive-bladder-symptoms
#33
JOURNAL ARTICLE
Connor McPhail, Robert Carey, Sidharth Nambiar, Nadia Willison, Saghi Bahadori, Pouria Aryan, Tran Nguyen, Fariba Behnia-Willison
BACKGROUND: Overactive bladder (OAB) syndrome affects 10-15% of women, severely impacting their quality of life. First-line treatments include behavioural and physical therapy, and second-line medical treatments include medications such as vaginal oestrogen, anticholinergic medications, and ß3-adrenergic agonists-with potential adverse side effects including dizziness, constipation, and delirium, particularly affecting elderly populations. Third-line treatments include more invasive measures, including intradetrusor botulinum injections or sacral nerve modulation, with percutaneous tibial nerve stimulation (PTNS) being a potential alternative treatment...
May 16, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37214443/one-stone-two-birds-anti-inflammatory-bronchodilators-as-a-potential-pharmacological-strategy-for-covid-19
#34
REVIEW
Yuanyuan Yu, Bangjiang Fang, Xiao-Dong Yang, Yuejuan Zheng
The ongoing Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has imposed a huge threat to public health across the world. While vaccinations are essential for reducing virus transmission and attenuating disease severity, the nature of high mutation rate of SARS-CoV-2 renders vaccines less effective, urging quick development of effective therapies for COVID-19 disease. However, developing novel drugs remains extremely challenging due to the lengthy process and high cost...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37200957/neuroleptic-malignant-syndrome-improved-with-intramuscular-administration-of-the-anticholinergic-agent-biperiden
#35
Koichi Nisijima
Anticholinergic drugs, such as biperiden, benztropine, and diphenhydramine, were used for neuroleptic malignant syndrome (NMS) in the 1980s and 1990s. However, they have not been recommended for pharmacotherapy in NMS since 2000, as they may prevent a decrease in body temperature by suppressing sweating. However, whether anticholinergic drugs actually exacerbate NMS remains unclear. This study highlights the usefulness of anticholinergic drugs, which are no longer attracting attention as current pharmacological treatments for NMS...
2023: International Medical Case Reports Journal
https://read.qxmd.com/read/37160401/oral-anticholinergic-drugs-versus-placebo-or-no-treatment-for-managing-overactive-bladder-syndrome-in-adults
#36
REVIEW
Akvile Stoniute, Priya Madhuvrata, Madeleine Still, Evelyn Barron-Millar, Ghulam Nabi, Muhammad Imran Omar
BACKGROUND: Around 16% of adults have symptoms of overactive bladder (OAB; urgency with frequency and/or urge incontinence), with prevalence increasing with age. Anticholinergic drugs are commonly used to treat this condition. This is an update of a Cochrane Review first published in 2002 and last updated in 2006. OBJECTIVES: To assess the effects of anticholinergic drugs compared with placebo or no treatment for treating overactive bladder syndrome in adults. SEARCH METHODS: We searched the Cochrane Incontinence Specialised Register, which contains trials identified from the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, MEDLINE In-Process, MEDLINE Epub Ahead of Print, ClinicalTrials...
May 9, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37085880/treating-incontinence-for-underlying-mental-and-physical-health-triumph-a-study-protocol-for-a-multicenter-double-blinded-randomized-3-arm-trial-to-evaluate-the-multisystem-effects-of-pharmacologic-treatment-strategies-for-urgency-predominant-urinary-incontinence
#37
JOURNAL ARTICLE
Alison J Huang, Louise C Walter, Kristine Yaffe, Eric Vittinghoff, Erica Kornblith, Michael Schembri, Ann Chang, Leslee L Subak
BACKGROUND: Urgency-type urinary incontinence affects one in four older community-dwelling women and overlaps with other common aging-associated health syndromes such as cognitive impairment, physical mobility impairment, and depression. Observational studies have raised concern about potentially higher rates of delirium and dementia in older adults taking anticholinergic bladder medications, but few prospective data are available to evaluate the effects of these and other pharmacologic treatments for urgency incontinence on cognition and other multisystem functional domains important to older women...
April 21, 2023: Trials
https://read.qxmd.com/read/37059654/from-one-to-many-hypertonia-in-schizophrenia-spectrum-psychosis-an-integrative-review-and-adversarial-collaboration-report
#38
JOURNAL ARTICLE
Jack R Foucher, Dusan Hirjak, Sebastian Walther, Ludovic C Dormegny-Jeanjean, Ilia Humbert, Olivier Mainberger, Clément C de Billy, Benoit Schorr, Laurent Vercueil, Jonathan Rogers, Gabor Ungvari, John Waddington, Fabrice Berna
Different types of resistance to passive movement, i.e. hypertonia, were described in schizophrenia spectrum disorders (SSD) long before the introduction of antipsychotics. While these have been rediscovered in antipsychotic-naïve patients and their non-affected relatives, the existence of intrinsic hypertonia vs drug-induced parkinsonism (DIP) in treated SSD remains controversial. This integrative review seeks to develop a commonly accepted framework to specify the putative clinical phenomena, highlight conflicting issues and discuss ways to challenge each hypothesis and model through adversarial collaboration...
April 12, 2023: Schizophrenia Research
https://read.qxmd.com/read/37039960/pharmacological-risk-assessment-among-older-patients-with-polypharmacy-using-the-clinical-decision-support-system-janusmed-risk-profile-a-cross-sectional-register-study
#39
JOURNAL ARTICLE
Ludvig Petersson, Christian Schörgenhofer, Ylva Askfors, Hanna Justad, Marja-Liisa Dahl, Marine L Andersson
BACKGROUND: Polypharmacy in older people is steadily increasing and a combination of many medicines may result in adverse effects, especially if the medicines interact pharmacodynamically. Examples are additive or synergistic effects increasing the risk of falls, haemorrhage, serotonin syndrome and torsade de pointes. The clinical decision support system Janusmed Risk Profile has been developed to find such risks based on a patients' medication list. OBJECTIVES: The main aim of this retrospective register-based study was to study what pharmacodynamic risks older patients (aged 65 years or older) on polypharmacy (defined as using five or more medicines) are exposed to...
April 11, 2023: Drugs & Aging
https://read.qxmd.com/read/37006704/verbal-and-visual-learning-ability-in-patients-with-treatment-resistant-schizophrenia-a-1-year-follow-up-study
#40
JOURNAL ARTICLE
Urska Arnautovska, Kathryn Vitangcol, James P Kesby, Nicola Warren, Susan L Rossell, Erica Neill, Anthony Harris, Cherrie Galletly, David Castle, Dan Siskind
OBJECTIVE: In the general population, repeated cognitive testing produces learning effects with potential for improved test performance. It is currently unclear whether the same effect of repeated cognitive testing on cognition pertains to people living with schizophrenia, a condition often associated with significant cognitive impairments. This study aims to evaluate learning ability in people with schizophrenia and-considering the evidence that antipsychotic medication can additionally impair cognitive performance-explore the potential impact of anticholinergic burden on verbal and visual learning...
September 2023: Schizophrenia Research. Cognition
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