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glomerular filtration

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https://www.readbyqxmd.com/read/29917152/glomerular-filtration-rate-in-patients-with-multiple-sclerosis-undergoing-stem-cell-transplantation-and-treated-with-cyclophosphamide
#1
Alejandro Ruiz-Argüelles, Jose M Gastélum-Cano, Mariana A Méndez-Huerta, Alma B Rodríguez-Gallegos, Guillermo J Ruiz-Argüelles
Background: Glomerular filtration rate (GFR) is partially impaired in patients with multiple sclerosis (MS). When given chemotherapy before receiving hematopoietic stem-cell transplantation, GFR might be further deteriorated. Objective: To measure the effect of cyclophosphamide on GFR in patients with MS who undergo chemotherapy. Methods: We estimated GFR based on creatinine and cystatin C plasma concentrations in patients undergoing autologous hematopoietic stem-cell transplantation to treat their MS...
June 15, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29916741/combined-sglt1-and-sglt2-inhibitors-and-their-role-in-diabetes-care
#2
Thomas Danne, Torben Biester, Olga Kordonouri
The sodium-glucose cotransporter type 1 (SGLT1) is the primary transporter for absorption of glucose and galactose in the gastrointestinal tract. Inhibition blunts and delays postprandial glucose (PPG) excursion. Sodium-glucose cotransporter type 2 (SGLT2) is expressed in the kidney, where it reabsorbs 90% of filtered glucose. Thus, a dual SGLT1 and SGLT2 inhibition (compared with selective SGLT2 inhibition) could result in lower PPG and robust A1c reduction even in patients with reduced kidney function. Sotagliflozin is an oral potent dual inhibitor of the insulin-independent SGLT1 and SGLT2...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29915999/fampridine-is-a-substrate-and-inhibitor-of-human-oct2-but-not-of-human-mate1-or-mate2k
#3
Guangqing Xiao, Christopher Rowbottom, Carri Boiselle, Liang-Shang Gan
PURPOSE: The renal clearance of fampridine (Fampyra®, or Ampyra®) significantly exceeds the glomerular filtration rate, suggesting active renal secretion is likely the major elimination pathway. The goal of this study was to identify the renal transporters that are involved in the renal active secretion, and elucidate the active renal secretion mechanism of fampridine. METHODS: The uptake of fampridine to HEK-293 cells overexpressing human OCT2, MATE1 or MATE2K was determined in the absence and presence of Cimetidine, the prototypical inhibitor of the transporters...
June 18, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29915216/pharmacokinetics-of-fludarabine-and-its-association-with-clinical-outcomes-in-paediatric-haematopoietic-stem-cell-transplantation-patients
#4
Hyewon Chung, Kyung Taek Hong, Ji Won Lee, Su-Jin Rhee, Seokuee Kim, Seo Hyun Yoon, Kyung-Sang Yu, Hyoung Jin Kang
Fludarabine is used as a common component of conditioning regimens for haematopoietic stem cell transplantation (HSCT). However, knowledge regarding the pharmacokinetic characteristics of once-daily fludarabine dosing in children is limited. This study investigated the pharmacokinetics of fludarabine and evaluated its associations with clinical outcomes in paediatric patients. A total of 802 blood samples obtained from 43 paediatric patients who underwent HSCT were included in a population pharmacokinetic analysis using non-linear mixed-effects modelling...
June 18, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29915020/risk-of-preeclampsia-and-pregnancy-complications-in-women-with-a-history-of-acute-kidney-injury
#5
Jessica Sheehan Tangren, Wan Ahmad Hafiz Wan Md Adnan, Camille E Powe, Jeffrey Ecker, Kate Bramham, Michelle A Hladunewich, Elizabeth Ankers, S Ananth Karumanchi, Ravi Thadhani
An episode of clinically recovered acute kidney injury (r-AKI) has been identified as a risk factor for future hypertension and cardiovascular disease. Our objective was to assess whether r-AKI was associated with future preeclampsia and other adverse pregnancy outcomes and to identify whether severity of AKI or time interval between AKI and pregnancy was associated with pregnancy complications. We conducted a retrospective cohort study of women who delivered infants between 1998 and 2016 at Massachusetts General Hospital...
June 18, 2018: Hypertension
https://www.readbyqxmd.com/read/29914938/amino-acid-and-lipid-associated-plasma-metabolomic-patterns-are-related-to-healthspan-indicators-with-aging-in-humans
#6
Lawrence C Johnson, Christopher R Martens, Jessica R Santos-Parker, Candace J Bassett, Talia R Strahler, Charmion Cruickshank-Quinn, Nichole Reisdorph, Matthew B McQueen, Douglas R Seals
Advancing age is associated with impairments in numerous physiological systems, leading to an increased risk of chronic disease and disability, and reduced healthspan (the period of high functioning healthy life). The plasma metabolome is thought to reflect changes in the activity of physiological systems that influence healthspan. Accordingly, we utilized an LC-MS metabolomics analysis of plasma collected from healthy young and older individuals to characterize global changes in small molecule abundances with age...
June 18, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29914534/efficacy-of-low-protein-diet-for-diabetic-nephropathy-a-systematic-review-of-randomized-controlled-trials
#7
Huan-Gao Zhu, Zhao-Shun Jiang, Pi-Yun Gong, Dong-Mei Zhang, Zhi-Wei Zou, Qian-Zhang, Hui-Mei Ma, Zhen-Gang Guo, Jun-Yu Zhao, Jian-Jun Dong, Lin-Liao
BACKGROUND: A low-protein diet (LPD) is believed to be beneficial in slowing the progression of kidney disease. It is reported that low protein diet can improve protein, sugar and lipid metabolism, and reduce the symptoms and complications of renal insufficiency. However, there has been controversial regarding the effects of protein restriction on diabetic nephropathy (DN). OBJECTIVE: To investigate the efficacy of LPD on renal function in patients with type 1 or 2 DN by meta-analysis of randomized controlled trials (RCTs)...
June 19, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29914255/serum-vasohibin-1-and-suppression-of-tumorigenicity-2-levels-in-children-with-predialysis-chronic-kidney-disease
#8
Nuran Çetin, Nadide Melike Sav
Background/aim: Chronic kidney disease (CKD), which is one of the most important health problems worldwide, could be considered as an immune inflammatory disease. A prognostic biomarker may be helpful in determining the progression of CKD in children. We aimed to investigate the serum vasohibin-1 and soluble suppression of tumorigenicity-2 (sST2) levels as potential biomarkers in children with predialysis CKD. Materials and methods: Forty-seven children with stage 2-4 CKD and 20 healthy controls were included in this cross-sectional study...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29914158/mediterranean-diet-score-associations-with-metabolic-products-of-the-intestinal-microbiome-carotid-plaque-burden-and-renal-function
#9
Michael Pignanelli, Caroline Just, Chrysi Bogiatzi, Vincent Dinculescu, Gregory B Gloor, Emma Allen-Vercoe, Gregor Reid, Bradley L Urquhart, Kelsey N Ruetz, Thomas J Velenosi, J David Spence
Metabolic products of the intestinal microbiome such as trimethylamine N-oxide (TMAO) that accumulate in renal failure (gut-derived uremic toxins, GDUTs) affect atherosclerosis and increase cardiovascular risk. We hypothesized that patients on a Mediterranean diet and those consuming lower amounts of dietary precursors would have lower levels of GDUTs. Patients attending vascular prevention clinics completed a Harvard Food Frequency Questionnaire (FFQ) and had plasma levels of TMAO, p-cresylsulfate, hippuric acid, indoxyl sulfate, p-cresyl glucuronide, phenyl acetyl glutamine, and phenyl sulfate measured by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry...
June 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29913460/a-new-pathogenesis-of-albuminuria-role-of-transcytosis
#10
Fang-Fang He, Yi Gong, Zhen-Qiong Li, Liang Wu, Hua-Jun Jiang, Hua Su, Chun Zhang, Yu-Mei Wang
Transcytosis is an important intracellular transport process by which multicellular organisms selectively move cargoes from apical to basolateral membranes without disrupting cellular homeostasis. In kidney, macromolecular components in the serum, such as albumin, low-density lipoprotein and immunoglobulins, pass through the glomerular filtration barrier (GFB) and proximal tubular cells (PTCs) by transcytosis. Protein transcytosis plays a vital role in the pathology of albuminuria, which causes progressive destruction of the GFB structure and function...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29912952/effects-of-early-diuretic-response-to-carperitide-in-acute-decompensated-heart-failure-treatment-a-single-center-retrospective-study
#11
Yoshitaka Okuhara, Masanori Asakura, Kohei Azuma, Yoshiyuki Orihara, Koichi Nishimura, Tomotaka Ando, Hideyuki Kondo, Yoshiro Naito, Kazunori Kashiwase, Shinichi Hirotani, Masaharu Ishihara, Tohru Masuyama
BACKGROUND: Diuretic response is a strong predictor of outcome for admitted patients of acute decompensated heart failure (ADHF). However, little is known about the effects of early diuretic response to carperitide. METHODS: We retrospectively analyzed records of 85 patients hospitalized for ADHF who received carperitide as initial treatment and <40 mg furosemide during the early period. The eligible patients were divided into good diuretic responder (GR) group and poor diuretic responder (PR) group on the basis of median urinary volume...
2018: PloS One
https://www.readbyqxmd.com/read/29912597/cystatin-c-as-a-predictor-of-mortality-in-elderly-patients-with-chronic-kidney-disease
#12
Sebastjan Bevc, Nina Hojs, Maša Knehtl, Robert Ekart, Radovan Hojs
BACKGROUND: The prevalence of chronic kidney disease (CKD) in the elderly is high. Serum cystatin C is an accurate marker of kidney function and it also has prognostic utility in CKD patients. The aim of our study was to determine the prediction of serum cystatin C and other markers of kidney function on long-term survival in elderly CKD patients. METHODS: Fifty eight adult Caucasian patients, older than 65 years, without known malignancy, thyroid disease and/or not on steroid therapy were enrolled in the study...
June 18, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29911959/conversion-from-steroid-to-everolimus-in-maintenance-kidney-transplant-recipients-with-posttransplant-diabetes-mellitus
#13
Koji Nanmoku, Akira Kurosawa, Taro Kubo, Takahiro Shinzato, Toshihiro Shimizu, Takaaki Kimura, Takashi Yagisawa
OBJECTIVES: Although steroid withdrawal has been attempted to ameliorate various complications in kidney transplant recipients, a steroid-sparing strategy has more frequently led to acute rejection. We investigated the use of everolimus to safely overcome steroid withdrawal in kidney transplant recipients with posttransplant diabetes mellitus under maintenance immunosuppressive therapy. MATERIALS AND METHODS: A total of 75 de novo consecutive kidney transplant recipients received conventional immunosuppressive therapy comprising tacrolimus (trough level of 5 ng/mL), mycophenolate mofetil (1000 mg), and methylprednisolone (4 mg)...
June 18, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29911415/risk-factors-for-the-development-of-micro-vascular-complications-of-type-2-diabetes-in-a-single-centre-cohort-of-patients
#14
Marsida Teliti, Giulia Cogni, Lucia Sacchi, Arianna Dagliati, Simone Marini, Valentina Tibollo, Pasquale De Cata, Riccardo Bellazzi, Luca Chiovato
AIMS: In type 2 diabetes, we aimed at clarifying the role of glycated haemoglobin variability and other risk factors in the development of the main micro-vascular complications: peripheral neuropathy, nephropathy and retinopathy. METHODS: In a single-centre cohort of 900 patients, glycated haemoglobin variability was evaluated as intra-individual standard deviation, adjusted standard deviation and coefficient of variation of serially measured glycated haemoglobin in the 2-year period before a randomly selected index visit...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29911291/clinical-significance-of-perioperative-changes-in-ankle-brachial-index-with-regard-to-extremity-related-outcome-in-non-diabetic-patients-with-critical-limb-ischemia
#15
Moritz S Bischoff, K Meisenbacher, A S Peters, D Weber, T Bisdas, G Torsello, D Böckler
PURPOSE: To evaluate the significance of perioperative changes in ankle-brachial index (ABI) with regard to extremity-related outcome in non-diabetic patients with critical limb ischemia (CLI) following revascularization. METHODS: The study represents a subanalysis of the multicentric Registry of First-line Treatment in Patients with CLI (CRITISCH). After exclusion of diabetic patients, conservative cases, and primary major amputation, 563 of 1200 CRITISCH patients (mean age 74 ± 10...
June 17, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29910771/use-of-readily-accessible-inflammatory-markers-to-predict-diabetic-kidney-disease
#16
REVIEW
Lauren Winter, Lydia A Wong, George Jerums, Jas-Mine Seah, Michele Clarke, Sih Min Tan, Melinda T Coughlan, Richard J MacIsaac, Elif I Ekinci
Diabetic kidney disease is a common complication of type 1 and type 2 diabetes and is the primary cause of end-stage renal disease in developed countries. Early detection of diabetic kidney disease will facilitate early intervention aimed at reducing the rate of progression to end-stage renal disease. Diabetic kidney disease has been traditionally classified based on the presence of albuminuria. More recently estimated glomerular filtration rate has also been incorporated into the staging of diabetic kidney disease...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29910024/dulaglutide-versus-insulin-glargine-in-patients-with-type-2-diabetes-and-moderate-to-severe-chronic-kidney-disease-award-7-a-multicentre-open-label-randomised-trial
#17
Katherine R Tuttle, Mark C Lakshmanan, Brian Rayner, Robert S Busch, Alan G Zimmermann, D Bradley Woodward, Fady T Botros
BACKGROUND: Many antihyperglycaemic drugs, including insulin, are primarily cleared by the kidneys, restricting treatment options for patients with kidney disease. Dulaglutide is a long-acting glucagon-like peptide-1 receptor agonist that is not cleared by the kidneys, and confers a lower risk of hypoglycaemia than does insulin. We assessed the efficacy and safety of dulaglutide in patients with type 2 diabetes and moderate-to-severe chronic kidney disease. METHODS: AWARD-7 was a multicentre, open-label trial done at 99 sites in nine countries...
June 14, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29909935/ckd-and-sedentary-time-results-from-the-canadian-health-measures-survey
#18
Tamara Glavinovic, Thomas Ferguson, Paul Komenda, Claudio Rigatto, Todd A Duhamel, Navdeep Tangri, Clara Bohm
RATIONALE & OBJECTIVE: Sedentary behavior and low physical activity are associated with incident diabetes, cardiovascular disease, and early mortality. Previous studies have examined associations between chronic kidney disease (CKD) and physical activity, but little is known about the role of sedentary time. STUDY DESIGN: Cross-sectional national survey. SETTING & PARTICIPANTS: A nationally representative sample of adults (n=8,444) participating in the Canadian Health Measures Survey's (CHMS) activity monitoring component (2007-2013)...
June 14, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29909373/what-insights-do-patients-and-caregivers-have-on-acute-kidney-injury-and-posthospitalisation-care-a-single-centre-qualitative-study-from-toronto-canada
#19
Samuel A Silver, Marianne Saragosa, Neill K Adhikari, Chaim M Bell, Ziv Harel, Andrea Harvey, Abhijat Kitchlu, Javier A Neyra, Ron Wald, Lianne Jeffs
OBJECTIVES: Hospitalisation with acute kidney injury (AKI) is associated with short-term and long-term adverse events, but patient and caregiver experiences with AKI are not well described. We sought to better understand patient and caregiver perspectives after a hospitalisation with AKI to inform discharge strategies that may improve outcomes for this high-risk population. DESIGN: Qualitative study with semistructured interviews. SETTING: Tertiary care hospital in Toronto, Ontario, Canada...
June 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29909116/altered-microrna-regulation-of-short-chain-fatty-acid-receptors-in-the-hypertensive-kidney-is-normalized-with-hydrogen-sulfide-supplementation
#20
Gregory J Weber, Jaleyea Foster, Sathnur B Pushpakumar, Utpal Sen
Hypertension affects nearly one third of the adult US population and is a significant risk factor for chronic kidney disease (CKD). An expanding body of recent studies indicates that gut microbiome has crucial roles in regulating physiological processes through, among other mechanisms, one mode of short chain fatty acids (SCFA) and their target receptors. In addition, these SCFA receptors are potential targets of regulation by host miRNAs, however, the mechanisms through which this occurs is not clearly defined...
June 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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