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glomerular filtration

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https://www.readbyqxmd.com/read/29228124/association-of-estimated-glomerular-filtration-rate-with-muscle-function-in-older-persons-who-have-fallen
#1
Lisanne Tap, Nicole D A Boyé, Klaas A Hartholt, Tischa J M van der Cammen, Francesco U S Mattace-Raso
Background: studies suggest that estimated glomerular filtration rate (eGFR) is less reliable in older persons and that a low serum-creatinine might reflect reduced muscle mass rather than high kidney function. This study investigates the possible relationship between eGFR and multiple elements of physical performance in older fallers. Methods: baseline data of the IMPROveFALL-study were examined in participants ≥65 years. Serum-creatinine based eGFR was classified as normal (≥90 ml/min), mildly reduced (60-89 ml/min) or moderately-severely reduced (<60 ml/min)...
December 8, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29227974/mir302a-3p-may-modulate-renal-epithelial-mesenchymal-transition-in-diabetic-kidney-disease-by-targeting-zeb1
#2
Wen-Bin Tang, Linfeng Zheng, Renheng Yan, Jiayi Yang, Jianping Ning, Linlin Peng, Qiaoling Zhou, Liping Chen
BACKGROUND: Recent study found that microRNA (miRNA) are involved in diabetic kidney disease (DKD). The objective of this study is to determine the role of miR302a-3p in the process of renal epithelial-mesenchymal transition (EMT) in DKD. METHODS: The miRNA expression profiling of the cell line stimulated by high glucose was performed by a microarray analysis. Then real-time polymerase chain reaction (PCR) were used to determine the expression of one of the miRNAs significantly upregulated in cell line stimulated by high glucose, miR302a-3p...
December 8, 2017: Nephron
https://www.readbyqxmd.com/read/29227972/serum-hepcidin-and-iron-indices-affect-anemia-status-differently-according-to-the-kidney-function-of-non-dialysis-chronic-kidney-disease-patients-korean-cohort-study-for-outcome-in-patients-with-chronic-kidney-disease-know-ckd
#3
Sung Woo Lee, Yeong Hoon Kim, Wookyung Chung, Sue K Park, Dong Wan Chae, Curie Ahn, Yong-Soo Kim, Su Ah Sung
BACKGROUND/AIMS: No studies have examined the association among serum hepcidin, iron indices, or anemia status based on the kidney function of non-dialysis chronic kidney disease (CKD) patients. METHODS: We reviewed data of 2238 patients from a large-scale multicenter prospective Korean study (2011-2016) and excluded 198 patients with missing data regarding serum hepcidin, hemoglobin, transferrin saturation (TSAT), ferritin, and usage of erythropoiesis-stimulating agents (ESA) or supplemental iron and 363 patients using ESA or supplemental iron...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29227971/association-of-1082a-g-polymorphism-in-the-interleukin-10-gene-with-estimated-glomerular-filtration-rate-in-type-2-diabetes
#4
Evelise Regina Polina, Bruna Letícia da Silva Pereira, Daisy Crispim, Renan Cesar Sbruzzi, Luis Henrique Canani, Kátia Gonçalves Dos Santos
BACKGROUND/AIMS: The -1082A>G polymorphism (rs1800896) in the interleukin-10 (IL10) gene has been associated with type 2 diabetes and diabetic retinopathy, but its relationship with diabetic kidney disease (DKD) is uncertain. The aim of this case-control study was to investigate whether the -1082A>G polymorphism is associated with DKD in white Brazilians with type 2 diabetes mellitus. METHODS: Genotyping was done by real-time polymerase chain reaction for 597 type 2 diabetic outpatients...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29227259/hypothyroidism-a-special-comorbidity-factor-in-patients-with-osteoarthrosis-clinical-pathophysiological-and-prognostic-aspects
#5
L Voloshyna, О Doholich, I Sithinska
Objective - to study the features of the functional and morphological condition of the thyroid gland (TG) in patients with osteoarthrosis (OA), the incidence and forms of hypothyroidism and their effects on clinical manifestations, metabolic disorders and the results of the treatment of OA and comorbid processes. A complex examination involved 312 patients with OA aged 37-76 years. Methods used: anthropometric, clinical, ultrasonographic, biochemical, radioimmunological (levels of TSH, free thyroxine, antibodies to thyroid peroxidase)...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29226648/fibulin-levels-in-autosomal-dominant-polycystic-kidney-disease-and-its-relationship-to-arterial-stiffness
#6
A Inci, O Akin, H Y Ellidag, E Eren, S Dolu, F Sari
BACKGROUND: The objective of the present study was to evaluate fibulin 1 levels in different stages of patients with autosomal dominant polycystic kidney disease (ADPKD) and investigate possible connections between fibulin-1 and arterial stiffness. METHODS: For this cross-sectional study, we included 74 patients with ADPKD (mean age, 50.92 ± 15.70 years) and 32 healthy controls (mean age, 49.53 ± 7.32 years). Patients with ADPKD were classified based on CKD epidemiology collaboration (CKD-EPI) equation assessments of estimated glomerular filtration rate (eGFR)...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29226570/campath-calcineurin-inhibitor-reduction-and-chronic-allograft-nephropathy-the-3c-study-results-of-a-randomized-controlled-clinical-trial
#7
Richard Haynes, Lisa Blackwell, Natalie Staplin, William G Herrington, Jonathan Emberson, Parminder K Judge, Benjamin C Storey, Martin J Landray, Paul N Harden, Colin Baigent, Peter Friend
Calcineurin inhibitors (CNI e.g. tacrolimus) reduce short-term kidney transplant failure, but chronic nephrotoxicity may contribute to late transplant loss. Elective conversion to inhibitors of the mammalian target of rapamycin pathway (mTOR e.g. sirolimus) might avoid long-term CNI renal damage and improve outcomes. The 3C Study was a pragmatic randomized controlled trial comprising sequential randomizations between alemtuzumab and basiliximab induction therapy (at the time of surgery) and between tacrolimus and sirolimus maintenance therapy at 6-months post-transplant...
December 11, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29225814/perioperative-plasma-lyte-use-reduces-the-incidence-of-renal-replacement-therapy-and-hyperkalaemia-following-renal-transplantation-when-compared-with-0-9-saline-a-retrospective-cohort-study
#8
Anamika Adwaney, David W Randall, Mark J Blunden, John R Prowle, Christopher J Kirwan
Background: Kidney transplant recipients often receive large volumes of intravenous fluid replacement in the peri-operative period. Administration of 0.9% saline has previously been associated with acidosis, hyperkalaemia and acute kidney injury. The perioperative use of physiologically balanced replacement fluids may reduce the incidence of post-operative renal replacement therapy and hyperkalaemia. Methods: A retrospective review of consecutive renal transplants before and after a change in perioperative fluid prescription from 0...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29225807/renal-denervation-using-carbon-dioxide-renal-angiography-in-patients-with-uncontrolled-hypertension-and-moderate-to-severe-chronic-kidney-disease
#9
Mohammed Awais Hameed, Jonathan S Freedman, Richard Watkin, Arul Ganeshan, Indranil Dasgupta
Background: Chronic kidney disease (CKD) is the most common cause of secondary hypertension. More than half of the patients have uncontrolled hypertension (≥140/90 mmHg on three or more antihypertensive agents at optimum doses). Renal sympathetic denervation (RSDN) has been shown to reduce blood pressure (BP) in patients with resistant hypertension. Although patients with CKD have high sympathetic drive, all major clinical trials have excluded patients with estimated glomerular filtration rates (eGFRs) <45 mL/min/1...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29225129/hydrogen-sulfide-as-a-regulatory-factor-in-kidney-health-and-disease
#10
REVIEW
Balakuntalam S Kasinath, Denis Feliers, Hak Joo Lee
Hydrogen sulfide (H2S) is synthesized in nearly all organ systems including the kidney. Recent findings have revealed that H2S functions as a gasotransmitter affecting a wide range of physiologic functions similar to other gasotransmitters nitric oxide (NO) and carbon monoxide (CO). Research on H2S regulation of kidney function is still in early stages. H2S increases glomerular filtration rate (GFR) and inhibits sodium absorption by the tubules. There is burgeoning evidence that H2S generation by kidney cells is reduced in acute and chronic disease states and that H2S donors ameliorate injury...
December 7, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29224024/association-of-the-tg-hdl-c-and-non-hdl-c-hdl-c-ratios-with-chronic-kidney-disease-in-an-adult-chinese-population
#11
Jia Wen, Yiyin Chen, Yun Huang, Yao Lu, Xing Liu, Honghao Zhou, Hong Yuan
BACKGROUND/AIMS: Evidence indicates a role for dyslipidemia in the development of chronic kidney disease (CKD). However, the association of lipid abnormalities and their ratios with kidney disease using the new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood. METHODS: This cross-sectional study included 48,054 adult subjects. CKD was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m2 or dipstick-positive proteinuria...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29224015/renal-resistive-index-as-a-novel-indicator-for-renal-complications-in-high-fat-diet-fed-mice
#12
Hairong Xu, Zejun Ma, Shan Lu, Rui Li, Liangkun Lyu, Lexi Ding, Qiulun Lu
BACKGROUND/AIMS: The renal resistive index (RI) is a novel candidate as a renal injury prognostic indicator, but it remains unclear how renal RI levels correspond to renal injury in diabetic nephropathy. METHODS: To examine this issue, we compared 8-week-old male C57BL/6 mice fed with high-fat diet (HFD) versus chow diet (CHD) for 16 weeks. At 8 and 12 weeks, the glomerular filtration rate (GFR), urinary albumin-to-creatinine ratio (UACR), and inflammatory factors (IL-1β, IL-6, TNFα, and MCP-1) were measured, along with the increase in renal RI...
December 7, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29223859/outcome-of-pediatric-renal-transplantation-in-urological-versus-non-urological-causes-of-end-stage-renal-disease-does-it-matter
#13
Ahmed Aly Hussein, Ahmed Ismail Shoukry, Fatina Fadel, Hani Abdel-Raouf Morsi, Hussein Aly Hussein, Mostafa Sheba, Nada El-Khateeb, Waseem Abou-El Ela, Mohamed El-Sheemy, Kareem Daw, Ahmed Shouman, Amr Lotfy, Hisham Badawy, Mohamed Eissa
INTRODUCTION: Causes for end stage renal disease (ESRD) in children can be categorized into urological causes or non-urological causes. We sought to compare the outcomes of urological and non-urological causes of ESRD in children. METHODS: Patients were divided into two groups: urological causes of ESRD versus non-urological causes of ESRD. All patients and donors had at least 6 months of follow-up. The main outcomes included the effect on complications and renal function...
November 20, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29221627/alkaline-diet-and-metabolic-acidosis-practical-approaches-to-the-nutritional-management-of-chronic-kidney-disease
#14
Larissa Rodrigues Neto Angéloco, Gabriela Cristina Arces de Souza, Elen Almeida Romão, Paula Garcia Chiarello
The kidneys play an extremely important role in maintaining the body acid-base balance by excreting nonvolatile acids and regenerating and reabsorbing bicarbonate in the kidney tubules. As the individual loses their kidney function, renal excretion of nonvolatile acid produced by metabolism of the diet is impaired, resulting in low-grade metabolic acidosis. With this in mind, it is relevant to better understand the dietary aspects related to the acid-base balance in chronic kidney disease metabolic acidosis and try to provide possible strategies for the nutritional management of these cases...
December 5, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29221436/prevalence-and-related-risk-factors-of-chronic-kidney-disease-among-adults-in-luxembourg-evidence-from-the-observation-of-cardiovascular-risk-factors-oriscav-lux-study
#15
Ala'a Alkerwi, Nicolas Sauvageot, Illiasse El Bahi, Charles Delagardelle, Jean Beissel, Stephanie Noppe, Paul J Roderick, Jennifer S Mindell, Saverio Stranges
BACKGROUND: Evidence on stages of renal impairment and related risk factors in Luxembourg is lacking. This study aimed to assess the prevalence of chronic kidney disease (CKD) and identify potential correlates among the general population, using the recent definition suggested by the Kidney Disease Improving Global Outcomes guidelines. METHODS: Data analysed from 1361 participants aged 18-69 years, enrolled in the Observation of Cardiovascular Risk Factors in Luxembourg (ORISCAV-LUX) study, 2007-08...
December 8, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29219869/comparison-of-vegetarian-versus-animal-based-low-protein-diets-on-estimated-glomerular-filtration-rates-in-chronic-kidney-disease-patients-a-systematic-review-protocol
#16
Kruti Patel, Kim W Hoover
The objective of this review is to evaluate studies to determine the effect of a low-protein, vegetarian diet as compared to a low-protein, animal-based diet on estimated glomerular filtration rates (eGFR) in adults with chronic kidney disease (CKD).
December 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29218435/educational-review-measurement-of-gfr-in-special-populations
#17
Guido Filler, Misan Lee
IMPORTANCE: Changes in kidney function are typically followed by the sequential estimation of glomerular filtration rate (eGFR). Formulae for eGFR work well on a population basis, but there are well-known conditions where they do not work. OBJECTIVE: The purpose of this review is to summarize the existing literature on special populations in the pediatric age range and provide recommendations on how to estimate GFR in these populations. FINDINGS: The reliability of creatinine depends on muscle mass, while cystatin C (not widely available) is limited by inflammation and changes in protein catabolism...
December 7, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29217892/bowel-migration-of-dormant-chronic-ambulatory-peritoneal-dialysis-catheter-a-vexed-problem-not-avoided-by-flushing
#18
P Vincent, J Gopinathan, R Narayanan
Delayed bowel erosion by peritoneal dialysis catheter is rare with fewer than thirty cases having been reported in the literature. This complication is usually encountered when the catheter is kept dormant. Two cases have also been reported with catheters in active use. The risk factors for bowel erosion include immunosuppression, diverticulosis, and amyloidosis. An 80-year-old male with chronic kidney disease Stage 5 due to hypertensive nephrosclerosis underwent chronic ambulatory peritoneal dialysis catheter insertion...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29217675/ten-year-mortality-in-the-wise-study-women-s-ischemia-syndrome-evaluation
#19
Tanya S Kenkre, Pankaj Malhotra, B Delia Johnson, Eileen M Handberg, Diane V Thompson, Oscar C Marroquin, William J Rogers, Carl J Pepine, C Noel Bairey Merz, Sheryl F Kelsey
BACKGROUND: The WISE study (Women's Ischemia Syndrome Evaluation) was a prospective cohort study of 936 clinically stable symptomatic women who underwent coronary angiography to evaluate symptoms and signs of ischemia. Long-term mortality data for such women are limited. METHODS AND RESULTS: Obstructive coronary artery disease (CAD) was defined as ≥50% stenosis on angiography by core laboratory. We conducted a National Death Index search to assess the mortality of women who were alive at their final WISE contact date...
December 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29217578/a-small-molecule-inhibitor-of-trpc5-ion-channels-suppresses-progressive-kidney-disease-in-animal-models
#20
Yiming Zhou, Philip Castonguay, Eriene-Heidi Sidhom, Abbe R Clark, Moran Dvela-Levitt, Sookyung Kim, Jonas Sieber, Nicolas Wieder, Ji Yong Jung, Svetlana Andreeva, Jana Reichardt, Frank Dubois, Sigrid C Hoffmann, John M Basgen, Mónica S Montesinos, Astrid Weins, Ashley C Johnson, Eric S Lander, Michael R Garrett, Corey R Hopkins, Anna Greka
Progressive kidney diseases are often associated with scarring of the kidney's filtration unit, a condition called focal segmental glomerulosclerosis (FSGS). This scarring is due to loss of podocytes, cells critical for glomerular filtration, and leads to proteinuria and kidney failure. Inherited forms of FSGS are caused by Rac1-activating mutations, and Rac1 induces TRPC5 ion channel activity and cytoskeletal remodeling in podocytes. Whether TRPC5 activity mediates FSGS onset and progression is unknown. We identified a small molecule, AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats...
December 8, 2017: Science
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