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https://www.readbyqxmd.com/read/29161710/distribution-of-hepatitis-c-virus-genotypes-and-subtypes-in-the-metropolitan-area-of-naples-italy-in-the-era-of-interferon-free-regimens
#1
Elena Grimaldi, Maria Elena Della Pepa, Francesca Martora, Pasqualino Magliocca, Maria Rosaria Iovene, Nicola Coppola, Giovanna Donnarumma, Massimiliano Galdiero
AIMS: The objective of this work was to study the distribution of hepatitis C virus (HCV) genotypes and subtypes from 2010 to 2015 in 1,221 anti-HCV/HCV-RNA-positive specimens from patients living in the metropolitan area of Naples, since HCV genotypes and subtypes remain cornerstones in the management of chronic HCV infection even in the directly acting antivirals era. METHODS: The study was carried out on 1,221 anti-HCV/HCV-RNA-positive plasma samples collected between April 2010 and December 2015...
November 22, 2017: Intervirology
https://www.readbyqxmd.com/read/29161519/bioinformatics-advances-to-accelerate-omics-innovations-and-applications-in-the-postgenomic-era
#2
Jayshree Advani, Yashwanth Subbannayya, Harsha Gowda, Aditi Chatterjee
No abstract text is available yet for this article.
November 21, 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29161396/demands-and-requests-for-inappropriate-or-inadvisable-treatments-at-the-end-of-life-what-do-you-do-at-2-o-clock-in-the-morning-when-%C3%A2
#3
L McCrossan, R Siegmeth
In an era when healthcare has become increasingly complex and patient expectations are higher than ever before, we can find the decision-making process for patients, potentially at the end of their lives, increasingly difficult. In the shift from paternalism to patient choice, we can struggle to know what to do when faced with a patient, their family, or both requesting or demanding inadvisable, inappropriate, or futile treatments. It can feel as if we are being asked to subject patients to intrusions and interventions that 'just feel wrong'...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29161390/thiopental-to-desflurane-an-anaesthetic-journey-where-are-we-going-next
#4
J R Sneyd
Development targets in anaesthetic pharmacology have evolved from minimizing harm caused by unwanted effects through an era in which rapid onset and offset of drug effect were prioritised. Today's anaesthetists have access to a library of effective drugs whose characteristics offer controllable hypnosis, analgesia and paralysis with manageable off-target effects. The availability of these agents at generic prices inhibits commercial interest and this is reflected in the limited number of current anaesthetic drug development projects...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29161028/exploring-the-active-centre-of-lsd1-corest-complex-by-molecular-dynamics-simulation-utilizing-its-co-crystallized-cofactor-tetrahydrofolate-as-a-probe
#5
Waleed A A Zalloum, Hiba M Zalloum
Epigenetic targeting of cancer is a recent era to manipulate the gene without destroying the genetic material. Lysine-specific demethylase 1 (LSD1) is one of the enzymes associated with the chromatin for post-translational modifications, where it demethylates lysine amino acid in the chromatin H3 tail. Many studies showed that inhibiting LSD1 could potentially be used to treat cancer epigenetically. LSD1 is associated with its corepressor protein CoREST, and uses tetrahydrofolate as a cofactor to accept CH2 from the demethylation process...
November 21, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29161012/top-down-proteomics-ready-for-prime-time
#6
Bifan Chen, Kyle A Brown, Ziqing Lin, Ying Ge
In the post-genomics era, the study of proteins is critical for understanding cellular functions at the molecular level.1-5 Beyond the genetic code, the human proteome is greatly diversified by various genetic variations, alternative splicing of RNA transcripts, and post-translational modifi-cations (PTMs).6,7 In 2013, the term "proteoform" was designated to describe "all of the different molecular forms in which the protein product of a single gene can be found",6 clearing up the confusion in nomenclature and joining research efforts to develop methodologies for pro-teoform characterization...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29160909/revisiting-chronic-rejection-following-living-donor-liver-transplantation-in-the-tacrolimus-era-a-single-centre-experience
#7
Narendra Singh Choudhary, Neeraj Saraf, Sanjiv Saigal, Dheeraj Gautam, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Thiagrajan Srinivasan, Sanjay Kumar Yadav, Arvinder Soin
BACKGROUND AND AIMS: Chronic rejection (CR) is an uncommon but important cause of graft dysfunction, leading to graft loss and often requires re-transplantation. This study evaluates the incidence and outcome of patients with CR at a large living donor liver transplant (LDLT) centre. METHODS: Data of patients with CR was retrospectively analyzed in 1232 adult (age >18 years) LDLT on Tacrolimus (mainly) based immunosuppression. Sirolimus/Everolimus (mTOR inhibitors) were added to baseline immunosuppression as rescue therapy in patients with CR...
November 21, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29160555/the-effect-of-sleep-disorders-sedating-medications-and-depression-on-cognitive-processing-therapy-outcomes-a-fuzzy-set-qualitative-comparative-analysis
#8
Patricia L Haynes, Sarah E Emert, Dana Epstein, Suzanne Perkins, Sairam Parthasarathy, James Wilcox
Cognitive processing therapy (CPT) for posttraumatic stress disorder (PTSD) is an effortful process requiring engagement in cognitive restructuring. Sleep disorders may lead to avoidance of effortful tasks and cognitive performance deficits. We explored whether sleep disorders, as assessed by polysomnography, were consistently associated with treatment response in combination with other factors. This study included 32 U.S. veterans who were examined both before and after CPT for combat-related PTSD. We employed a novel, case-comparative technique, fuzzy set qualitative comparative analysis (fsQCA), to identify combinations of fuzzy and crisp factors (recipes) that achieve a clinically significant outcome...
November 21, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29160109/editorial-comment-on-end-2017-0618-or-r1
#9
Mordechai Duvdevani
Percutaneous nephrolithotomy (PCNL) is currently the treatment of choice for large and complex renal calculi. One of the main advantages of PCNL is gaining a real stone-free status in a single session. However, there are several major complications that necessitate careful patient selection for this surgery (1). In this well written manuscript the authors deal with the true rates and importance of residual fragments following PCNL surgeries done in a high volume center. They reviewed 658 PCNL procedures from 2008-2013 that underwent a CT scan on post-operative day one...
November 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29160048/from-biodegradable-polymers-to-bioresorbable-vascular-scaffolds-available-evidence-in-the-current-era-of-new-generation-des
#10
Fabio Magliulo, Raffaele Piccolo, Anna Franzone, Giovanni Esposito, Gian B Danzi
New-generation drug-eluting stents (DES) encompass a large variety of coronary devices, featuring thin struts, biocompatible durable or biodegradable polymer coatings, and limus-eluting drugs. Due to improved early and long-term outcomes among patients undergoing percutaneous coronary intervention, new-generation metallic DES are recommended in almost all patient and lesion subsets. Available evidence from randomized trials indicate a similar safety and efficacy profile between biodegradable and durable polymers new-generation DES...
November 20, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29159745/prognostic-value-of-tumor-volume-in-glioblastoma-patients-size-also-matters-for-patients-with-incomplete-resection
#11
Stefanie Bette, Melanie Barz, Benedikt Wiestler, Thomas Huber, Julia Gerhardt, Niels Buchmann, Stephanie E Combs, Friederike Schmidt-Graf, Claire Delbridge, Claus Zimmer, Jan S Kirschke, Bernhard Meyer, Yu-Mi Ryang, Florian Ringel, Jens Gempt
BACKGROUND: Incomplete resection of glioblastoma is discussed controversially in the era of combined radiochemotherapy. OBJECTIVE: The aim of this study was to analyze the benefit of subtotal tumor resection for glioblastoma patients as this was recently questioned in the era of radiochemotherapy. METHODS: Overall, 209 patients undergoing surgery for newly diagnosed WHO grade IV gliomas were retrospectively analyzed, and pre- and postoperative tumor volumes were manually segmented (cm(3))...
November 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29159743/morbidity-and-outcomes-following-axillary-lymphadenectomy-for-melanoma-weighing-the-risk-of-surgery-in-the-era-of-mslt-ii
#12
Lauren M Postlewait, Clara R Farley, Alexandra M Seamens, Nina Le, Monica Rizzo, Maria C Russell, Michael C Lowe, Keith A Delman
BACKGROUND: Limited data exist characterizing complications after axillary lymphadenectomy for melanoma. With high rates of complications reported after dissection for breast cancer and data suggesting that completion lymphadenectomy may have limited therapeutic benefit, this study characterized morbidity to facilitate clinical decision-making. METHODS: Using a broad definition for complications, patients who underwent axillary dissection for melanoma at a single center (from 2003 to 2015) were assessed through retrospective chart review...
November 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29159260/public-health-approach-to-prevent-cervical-cancer-in-hiv-infected-women-in-kenya-issues-to-consider-in-the-design-of-prevention-programs
#13
REVIEW
Sonia Menon, Rodolfo Rossi, Stacy G Harmon, Hillary Mabeya, Steven Callens
Women living with HIV in Africa are at increased risk to be co-infected with Human Papilloma Virus (HPV), persistent high risk (HR) HPV infection and bacterial vaginosis (BV), which compounds HPV persistence, thereby increasing the risk for cervical dysplasia. New guidance from WHO in 2014 advocating for a "screen and treat" approach in resource poor settings is becoming a more widely recommended screening tool for cervical cancer prevention programs in such contexts. This review article summarizes the risk factors to be considered when designing a primary and secondary cervical prevention program in a post-vaccination era for HIV-infected women in Kenya...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29158373/revisiting-expectations-in-an-era-of-precision-oncology
#14
Emily J Marchiano, Andrew C Birkeland, Paul L Swiecicki, Kayte Spector-Bagdady, Andrew G Shuman
As we enter an era of precision medicine and targeted therapies in the treatment of metastatic cancer, we face new challenges for patients and providers alike as we establish clear guidelines, regulations, and strategies for implementation. At the crux of this challenge is the fact that patients with advanced cancer may have disproportionate expectations of personal benefit when participating in clinical trials designed to generate generalizable knowledge. Patient and physician goals of treatment may not align, and reconciliation of their disparate perceptions must be addressed...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29158036/paediatric-weight-estimation-by-age-in-the-digital-era-optimising-a-necessary-evil
#15
Nicholas Appelbaum, Jonathan Clarke, Ian Maconochie, Ara Darzi
BACKGROUND: Age-based weight estimation methods are regularly used in paediatric emergency medicine despite their well-established inaccuracy. AIM: Determine the potential improvement in accuracy achievable by the use of a new mobile application, based on CDC/WHO weight-for-age centile data, which incorporates a gender assignment, a body habitus assessment, and which is capable of an age-in-months based calculation. METHODS: A theoretical, simulated validation study, comparing the performance of the widely used APLS/EPALS formulae against two contemporary habitus-adjusted methods, and the Helix Weight Estimation Tool...
November 17, 2017: Resuscitation
https://www.readbyqxmd.com/read/29158030/the-role-of-ayurveda-management-in-preventing-surgical-site-infections-instead-of-surgical-antibiotic-prophylaxis
#16
Subhash Yadav, Sanjay Jain, Jatinder Chaudhary, Rahul Bansal, Manoj Sharma
It is probably for the first time in the history of modern surgery that Benign Prostate Hyperplasia (BPH) surgery which belongs to 'clean contaminated' class and requires at least 3 doses of prophylactic antibiotic as per recommendations by American Urology Association, was done without the use of any as the patient had a history of severe intolerance to them. The case was an 83 year old male patient presenting with acute urinary retention. He was a known case of BPH being managed continuously on Ayurvedic therapy for many years...
November 17, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29157596/molecular-epidemiology-and-phylogenetic-analysis-of-human-papillomavirus-infection-in-women-with-cervical-lesions-and-cancer-from-the-coastal-region-of-ecuador
#17
Cesar H Bedoya-Pilozo, Lex G Medina Magües, Maylen Espinosa-García, Martha Sánchez, Johanna V Parrales Valdiviezo, Denisse Molina, María A Ibarra, María Quimis-Ponce, Karool España, Karla E Párraga Macias, Nancy V Cajas Flores, Solon A Orlando, Jorge A Robalino Penaherrera, Peter Chedraui, Saul Escobar, Rita D Loja Chango, Cecibel Ramirez-Morán, Jasson Espinoza-Caicedo, Sunny Sánchez-Giler, Celia M Limia, Yoan Alemán, Yudira Soto, Vivian Kouri, Andrés C A Culasso, Inés Badano
The aim of the present study was to gather information regarding the molecular epidemiology of Human papillomavirus (HPV) and related risk factors in a group of women with low- and high-grade cervical lesions and cancer from the coastal region of Ecuador. In addition, we studied the evolution of HPV variants from the most prevalent types and provided a temporal framework for their emergence, which may help to trace the source of dissemination within the region. We analyzed 166 samples, including 57 CIN1, 95 CIN2/3 and 14 cancer cases...
November 17, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29156713/the-prognostic-impact-of-overall-treatment-time-on-disease-outcome-in-uterine-cervical-cancer-patients-treated-primarily-with-concomitant-chemoradiotherapy-a-nationwide-taiwanese-cohort-study
#18
Shih-Min Lin, Hsiu-Ying Ku, Ting-Chang Chang, Tsang-Wu Liu, Ji-Hong Hong
The importance of the overall treatment time (OTT) has a paradoxical status in the current era of concomitant chemoradiotherapy. The main objective of this nationwide study was to evaluate the correlation between overall treatment duration and clinical outcome in cervical cancer patients treated primarily with curative concurrent chemoradiotherapy (CCRT). In this population-based cohort study, 2,594 patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage I-IVA uterine cervical cancer were studied...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156707/infradiaphragmatic-hodgkin-lymphoma-a-large-series-of-patients-staged-with-pet-ct
#19
Cédric Rossi, Morgane Mounier, Pauline Brice, Violaine Safar, Emmanuelle Nicolas-Virelizier, Philippe Rey, Aspasia Stamatoullas-Bastard, Marion Alcantara, Adrien Chauchet, Emilie Reboursière, Lauriane Filliatre, Aurore Perrot, Sylvain Garciaz, Gilles Salles, Bertrand Coiffier, Hervé Ghesquières, René-Olivier Casasnovas
Introduction: Infradiaphragmatic Hodgkin Lymphoma (IDHL) accounts for 3-11% of adult cases of stage I-II Hodgkin Lymphoma and the treatment strategy in IDHL is still heterogeneous. All previous published studies were conducted before the PET-CT era. PET may provide a more accurate evaluation of IDHL stage. The aim of this study was to analyze the clinical and biological characteristics of IDHL patients staged by CT scan or PET-CT in eight French hematology departments and their impact on outcomes in these patients...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156558/indoor-temperatures-in-low-cost-housing-in-johannesburg-south-africa
#20
Nisha Naicker, June Teare, Yusentha Balakrishna, Caradee Yael Wright, Angela Mathee
Ambient and indoor temperature affects thermal comfort and human health. In a changing climate with a predicted change in temperature extremes, understanding indoor temperatures, both hot and cold, of different housing types is important. This study aimed to assess the hourly, daily and monthly variation in indoor temperatures in different housing types, namely formal houses, informal houses, flats, government-built low-cost houses and old, apartheid era low-cost housing, in five impoverished urban communities in Johannesburg, South Africa...
November 18, 2017: International Journal of Environmental Research and Public Health
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