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mlac epinephrine

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https://www.readbyqxmd.com/read/16534344/current-status-and-clinical-relevance-of-studies-of-minimum-local-anaesthetic-concentration-mlac
#1
Bernhard M Graf, York Zausig, Wolfgang Zink
PURPOSE OF REVIEW: Studies comparing the effects of epidural local anaesthetics have been limited by the lack of knowledge of their relative potencies. In 1995 the concept of the minimum local-anaesthetic concentration (MLAC) was introduced, this has been defined primarily as the median effective analgesic concentration in the first stage of labour. Pharmacologically, this model aims to determine equipotent analgesic concentrations of local anaesthetics, to compare motor effects and to evaluate the relative toxicity during labour...
June 2005: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/11981152/effect-of-epidural-epinephrine-on-the-minimum-local-analgesic-concentration-of-epidural-bupivacaine-in-labor
#2
RANDOMIZED CONTROLLED TRIAL
Linda S Polley, Malachy O Columb, Norah N Naughton, Deborah S Wagner, Cosmas J M van de Ven
BACKGROUND: The minimum local analgesic concentration (MLAC) has been defined as the median effective local analgesic concentration in a 20-ml volume for epidural analgesia in the first stage of labor. The aim of this study was to determine the local anesthetic-sparing efficacy of epidural epinephrine by its effect on the MLAC of bupivacaine. METHODS: In this double-blind, randomized, prospective study, 70 parturients who were at 7 cm or less cervical dilation and who requested epidural analgesia were allocated to one of two groups...
May 2002: Anesthesiology
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