keyword
https://read.qxmd.com/read/38537153/novel-proteomic-signatures-may-indicate-mri-assessed-intrahepatic-fat-state-and-changes-the-direct-plus-clinical-trial
#1
JOURNAL ARTICLE
Dana T Goldberg, Anat Yaskolka Meir, Gal Tsaban, Ehud Rinott, Alon Kaplan, Hila Zelicha, Nora Klöting, Uta Ceglarek, Berend Iserman, Ilan Shelef, Philip Rosen, Matthias Blüher, Michael Stumvoll, Ohad Etzion, Meir J Stampfer, Frank B Hu, Iris Shai
OBJECTIVE: We demonstrated in the randomized 18-month DIRECT PLUS trial (n=294) that a Mediterranean (MED) diet, supplemented with polyphenol-rich Mankai duckweed, green tea, and walnuts and restricted in red/processed meat, caused substantial intrahepatic fat (IHF%) loss compared with two other healthy diets, reducing NAFLD by half, regardless similar weight loss. Here, we investigated the baseline proteomic profile associated with IHF% and the changes in proteomics associated with IHF% changes induced by lifestyle intervention...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38536505/metabolic-changes-contribute-to-maladaptive-right-ventricular-hypertrophy-in-pulmonary-hypertension-beyond-pressure-overload-an-integrative-imaging-and-omics-investigation
#2
JOURNAL ARTICLE
Inés García-Lunar, Inmaculada Jorge, Jorge Sáiz, Núria Solanes, Ana Paula Dantas, Juan José Rodríguez-Arias, María Ascaso, Carlos Galán-Arriola, Francisco Rafael Jiménez, Elena Sandoval, Jorge Nuche, Maria Moran-Garrido, Emilio Camafeita, Montserrat Rigol, Javier Sánchez-Gonzalez, Valentín Fuster, Jesús Vázquez, Coral Barbas, Borja Ibáñez, Daniel Pereda, Ana García-Álvarez
Right ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy in PH. To separate the effect of pressure overload from other potential mechanisms, we developed in pigs two experimental models of PH (M1, by pulmonary vein banding and M2, by aorto-pulmonary shunting) and compared them with a model of pure pressure overload (M3, pulmonary artery banding) and a sham-operated group...
March 27, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38535507/proteoform-analysis-of-the-human-olfactory-system-a-window-into-neurodegenerative-diseases
#3
REVIEW
Eqrem Rusi, Fiorenza Pennacchia, Wael Abu Ruqa, Giuseppina Talarico, Giuseppe Bruno, Antonio Minni, Christian Barbato
Background : Very little is known about the proteome of the human olfactory system and how diseases associated with olfactory dysfunctions can affect it. With this review, we try to summarize the existing literature on the use of this technique for a better understanding of the neurodegenerative disease process. Methods : We used the PubMed database and found different articles which were then selected independently by three authors. Results : We found 157 articles, of which, after careful selection, only 30 were analyzed in this review...
March 21, 2024: Proteomes
https://read.qxmd.com/read/38535505/quantitative-proteomics-reveal-region-specific-alterations-in-neuroserpin-deficient-mouse-brain-and-retina-insights-into-serpini1-function
#4
JOURNAL ARTICLE
Shahab Mirshahvaladi, Nitin Chitranshi, Ardeshir Amirkhani, Rashi Rajput, Devaraj Basavarajappa, Roshana Vander Wall, Dana Pascovici, Angela Godinez, Giovanna Galliciotti, Joao A Paulo, Veer Gupta, Stuart L Graham, Vivek Gupta, Mehdi Mirzaei
Neural regeneration and neuroprotection represent strategies for future management of neurodegenerative disorders such as Alzheimer's disease (AD) or glaucoma. However, the complex molecular mechanisms that are involved in neuroprotection are not clearly understood. A promising candidate that maintains neuroprotective signaling networks is neuroserpin (Serpini1), a serine protease inhibitor expressed in neurons which selectively inhibits extracellular tissue-type plasminogen activator (tPA)/plasmin and plays a neuroprotective role during ischemic brain injury...
March 14, 2024: Proteomes
https://read.qxmd.com/read/38535317/integrative-multiomics-approach-to-skin-the-sinergy-between-individualised-medicine-and-futuristic-precision-skin-care
#5
REVIEW
Angelica Dessì, Roberta Pintus, Vassilios Fanos, Alice Bosco
The skin is a complex ecosystem colonized by millions of microorganisms, the skin microbiota, which are crucial in regulating not only the physiological functions of the skin but also the metabolic changes underlying the onset of skin diseases. The high microbial colonization together with a low diversity at the phylum level and a high diversity at the species level of the skin is very similar to that of the gastrointestinal tract. Moreover, there is an important communication pathway along the gut-brain-skin axis, especially associated with the modulation of neurotransmitters by the microbiota...
March 7, 2024: Metabolites
https://read.qxmd.com/read/38535312/integrating-genome-sequencing-and-untargeted-metabolomics-in-monozygotic-twins-with-a-rare-complex-neurological-disorder
#6
Rulan Shaath, Aljazi Al-Maraghi, Haytham Ali, Jehan AlRayahi, Adam D Kennedy, Karen L DeBalsi, Sura Hussein, Najwa Elbashir, Sujitha S Padmajeya, Sasirekha Palaniswamy, Sarah H Elsea, Ammira A Akil, Noha A Yousri, Khalid A Fakhro
Multi-omics approaches, which integrate genomics, transcriptomics, proteomics, and metabolomics, have emerged as powerful tools in the diagnosis of rare diseases. We used untargeted metabolomics and whole-genome sequencing (WGS) to gain a more comprehensive understanding of a rare disease with a complex presentation affecting female twins from a consanguineous family. The sisters presented with polymicrogyria, a Dandy-Walker malformation, respiratory distress, and multiorgan dysfunctions. Through WGS, we identified two rare homozygous variants in both subjects, a pathogenic variant in ADGRG1 (p...
March 4, 2024: Metabolites
https://read.qxmd.com/read/38534769/deciphering-glioblastoma-fundamental-and-novel-insights-into-the-biology-and-therapeutic-strategies-of-gliomas
#7
REVIEW
Razvan Onciul, Felix-Mircea Brehar, Corneliu Toader, Razvan-Adrian Covache-Busuioc, Luca-Andrei Glavan, Bogdan-Gabriel Bratu, Horia Petre Costin, David-Ioan Dumitrascu, Matei Serban, Alexandru Vlad Ciurea
Gliomas constitute a diverse and complex array of tumors within the central nervous system (CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic interventions. This literature review endeavors to conduct a thorough investigation of gliomas, with a particular emphasis on glioblastoma (GBM), beginning with their classification and epidemiological characteristics, evaluating their relative importance within the CNS tumor spectrum. We examine the immunological context of gliomas, unveiling the intricate immune environment and its ramifications for disease progression and therapeutic strategies...
March 13, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534761/genetic-signatures-for-distinguishing-chemo-sensitive-from-chemo-resistant-responders-in-prostate-cancer-patients
#8
JOURNAL ARTICLE
Lemohang Gumenku, Mamello Sekhoacha, Beynon Abrahams, Samson Mashele, Aubrey Shoko, Ochuko L Erukainure
Prostate cancer remains a significant public health concern in sub-Saharan Africa, particularly impacting South Africa with high mortality rates. Despite many years of extensive research and significant financial expenditure, there has yet to be a definitive solution to prostate cancer. It is not just individuals who vary in their response to treatment, but even different nodules within the same tumor exhibit unique transcriptome patterns. These distinctions extend beyond mere differences in gene expression levels to encompass the control and networking of individual genes...
March 11, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38532423/association-of-trail-receptor-with-phosphatase-shp-1-enables-repressing-t-cell-receptor-signaling-and-t-cell-activation-through-inactivating-lck
#9
JOURNAL ARTICLE
I-Tsu Chyuan, Hsiu-Jung Liao, Tse-Hua Tan, Huai-Chia Chuang, Yu-Chuan Chu, Meng-Hsun Pan, Chien-Sheng Wu, Ching-Liang Chu, Bor-Ching Sheu, Ping-Ning Hsu
BACKGROUND: T cell receptor (TCR) signaling and T cell activation are tightly regulated by gatekeepers to maintain immune tolerance and avoid autoimmunity. The TRAIL receptor (TRAIL-R) is a TNF-family death receptor that transduces apoptotic signals to induce cell death. Recent studies have indicated that TRAIL-R regulates T cell-mediated immune responses by directly inhibiting T cell activation without inducing apoptosis; however, the distinct signaling pathway that regulates T cell activation remains unclear...
March 27, 2024: Journal of Biomedical Science
https://read.qxmd.com/read/38532129/proteomic-characteristics-of-the-treatment-trajectory-of-patients-with-covid-19
#10
JOURNAL ARTICLE
Xue Li, Guilan Ding, Shilin Li, Chun Liu, Xiangde Zheng, Jinliang Luo, Sichun He, Fanwei Zeng, Xuan Huang, Fanxin Zeng
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has prompted global concern due to its profound impact on public health and the economy. Effective treatment of COVID-19 patients in the acute phase or of those with long COVID is a major challenge. Using data-independent acquisition (DIA) technology, we performed proteomic profiling on plasma samples from 22 COVID-19 patients and six healthy controls at Dazhou Central Hospital. Random forest and least absolute shrinkage and selection operator algorithms were used for analysis at various COVID-19 treatment stages...
March 27, 2024: Archives of Virology
https://read.qxmd.com/read/38529348/copd-systemic-proteomic-profiles-in-frequent-and-infrequent-exacerbators
#11
JOURNAL ARTICLE
Cesar Jessé Enríquez-Rodríguez, Carme Casadevall, Rosa Faner, Ady Castro-Costa, Sergi Pascual-Guàrdia, Luis Seijó, José Luis López-Campos, Germán Peces-Barba, Eduard Monsó, Esther Barreiro, Borja G Cosío, Alvar Agustí, Joaquim Gea
BACKGROUND: Some patients with COPD suffer frequent exacerbations (FE). We hypothesised that their systemic proteomic profile would be different from that of non-frequent exacerbators (NFE). The objective of the present study was to contrast the systemic proteomic profile in FE versus NFE. As a reference, we also determined the systemic proteomic profile of healthy controls (HC) and COPD patients during an actual episode of exacerbation (AE). METHODS: In the analysis we included 40 clinically stable COPD patients (20 FE and 20 NFE), and 20 HC and 10 AE patients...
March 2024: ERJ Open Research
https://read.qxmd.com/read/38529180/multi-omics-approaches-to-understand-pathogenicity-during-potato-early-blight-disease-caused-by-alternaria-solani
#12
JOURNAL ARTICLE
Qing Li, Yan Feng, Jianmei Li, Yang Hai, Liping Si, Chen Tan, Jing Peng, Zuo Hu, Zhou Li, Canhui Li, Dahai Hao, Wei Tang
Potato early blight (PEB), a foliar disease of potato during the growing period, caused by Alternaria sp., is common in major potato-producing areas worldwide. Effective agents to control this disease or completely resistant potato varieties are absent. Large-scale use of fungicides is limited due to possibility of increase in pathogen resistance and the requirements of ecological agriculture. In this study, we focused on the composition and infection characteristics of early blight pathogens in Yunnan Province and screened candidate pathogenesis-related pathways and genes...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38528822/maladaptive-response-following-glucose-overload-in-glut4-overexpressing-h9c2-cardiomyoblasts
#13
JOURNAL ARTICLE
Bernd Stratmann, Britta Eggers, Yvonne Mattern, Tayana Silva de Carvalho, Katrin Marcus-Alic, Diethelm Tschoepe
BACKGROUND: Glucose overload drives diabetic cardiomyopathy by affecting the tricarboxylic acid pathway. However, it is still unknown how cells could overcome massive chronic glucose influx on cellular and structural level. METHODS/MATERIALS: Expression profiles of hyperglycemic, glucose transporter-4 (GLUT4) overexpressing H9C2 (KE2) cardiomyoblasts loaded with 30 mM glucose (KE230L) and wild type (WT) cardiomyoblasts loaded with 30 mM glucose (WT30L) were compared using proteomics, real-time polymerase quantitative chain reaction analysis, or Western blotting, and immunocytochemistry...
March 26, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38528561/transcriptome-and-open-chromatin-analysis-reveals-the-process-of-myocardial-cell-development-and-key-pathogenic-target-proteins-in-long-qt-syndrome-type-7
#14
JOURNAL ARTICLE
Peipei Chen, Junyu Long, Tianrui Hua, Zhifa Zheng, Ying Xiao, Lianfeng Chen, Kang Yu, Wei Wu, Shuyang Zhang
OBJECTIVE: Long QT syndrome type 7 (Andersen-Tawil syndrome, ATS), which is caused by KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal malformations. The development, differentiation and electrophysiological maturation of cardiomyocytes (CMs) changes promote the pathophysiology of Long QT syndrome type 7(LQT7). We aimed to specifically reproduce the ATS disease phenotype and study the pathogenic mechanism. METHODS AND RESULTS: We established a cardiac cell model derived from human induced pluripotent stem cells (hiPSCs) to the phenotypes and electrophysiological function, and the establishment of a human myocardial cell model that specifically reproduces the symptoms of ATS provides a reliable platform for exploring the mechanism of this disease or potential drugs...
March 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38528381/epigenetic-approaches-to-identifying-asthma-endotypes
#15
REVIEW
Audrey Kelly, Paul Lavender
The prevalence of asthma escalated rapidly in the late 20th century. In 2019, the World Health Organization estimated the global number of people affected by the condition to be approximately 260 million, causing 450,000 deaths during that year. While there have been advances in therapeutics with the emergence of biologics targeting T2-high asthma, there is still little clarity on the mechanisms underlying the origins of both the condition and all of its endotypes. Several biomarkers for particular asthma phenotypes have been documented...
March 2024: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/38527276/unpacking-immune-modulation-as-a-site-of-therapeutics-innovation-for-nematode-parasite-wuchereria-bancrofti-a-temporal-quantitative-phosphoproteomics-profiling-of-macrophage-migration-inhibitory-factor-2
#16
JOURNAL ARTICLE
Ishwar Singh, Anagha Kanichery, Chinmaya Narayana Kotimoole, Prashant Kumar Modi, Thottethodi Subrahmanya Keshava Prasad, Sugeerappa Laxamannappa Hoti
Nematode infections are common in both humans and livestock, with major adverse planetary health and economic impacts. Wuchereria bancrofti is a parasitic nematode that causes lymphatic filariasis, a neglected tropical disease that can lead to severe disability and deformity worldwide. For the long-term survival of the bancroftian parasites in the host, a complex immune invasion strategy is involved through immunomodulation. Therefore, immunomodulation can serve as a site of research and innovation for molecular targets...
March 2024: Omics: a Journal of Integrative Biology
https://read.qxmd.com/read/38527097/lipopolysaccharide-regulates-the-macrophage-rna-binding-proteome
#17
JOURNAL ARTICLE
Deepali Rathore, Matthew J Marino, Jiraphorn Issara-Amphorn, Sung Hwan Yoon, Nathan P Manes, Aleksandra Nita-Lazar
RNA-protein interactions within cellular signaling pathways have significant modulatory effects on RNA binding proteins' (RBPs') effector functions. During the innate immune response, specific RNA-protein interactions have been reported as a regulatory layer of post-transcriptional control. We investigated changes in the RNA-bound proteome of immortalized mouse macrophages (IMM) following treatment with lipopolysaccharide (LPS). Stable isotope labeling by amino acids in cell culture (SILAC) of cells followed by unbiased purification of RNP complexes at two time points after LPS stimulation and bottom-up proteomic analysis by LC-MS/MS resulted in a set of significantly affected RBPs...
March 25, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38526961/glutamine-promotes-porcine-intestinal-epithelial-cell-proliferation-through-the-wnt-%C3%AE-catenin-pathway
#18
JOURNAL ARTICLE
Yong-Xia Fang, En-Qing Lu, Yu-Jie Cheng, E Xu, Min Zhu, Xiang Chen
Glutamine (Gln) is a critical nutrient required by neonatal mammals for intestinal growth, especially for newborn piglets. However, the mechanisms underlying the role of Gln in porcine intestinal epithelium development are not fully understood. The objective of the current study was to explore the possible signaling pathway involved in the promotion of porcine intestinal epithelial cell (IPEC-J2) proliferation by Gln. The results showed that 1 mM Gln promoted IPEC-J2 cell proliferation, and tandem mass tag proteomics revealed 973 differentially expressed proteins in Gln-treated IPEC-J2 cells, 824 of which were upregulated and 149 of which were downregulated...
March 25, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38526390/restoration-of-pregnancy-function-using-gt-pcl-biofilm-in-a-rabbit-model-of-uterine-injury
#19
JOURNAL ARTICLE
Di Huang, Jing Liu, Jie Yang, Junhui Liang, Jing Zhang, Qinyu Han, Jianlong Yu, Tingting Yang, Qi Meng, Thorsten Steinberg, Zhongle Chang, Changzhong Li
Biomaterial scaffolds have been used successfully to promote the regenerative repair of small endometrial lesions in small rodents, providing partial restoration of gestational function. The use of rabbits in this study allowed us to investigate a larger endometrial tissue defect and myometrial-injury model. A gelatin/polycaprolactone (GT/PCL) gradient-layer biofilm was sutured at the defect to guide the reconstruction of the original tissue structure. 28 days post-implantation, the uterine cavity had been restored its original morphology; endometrial growth was accompanied by the formation of glands and blood vessels, and the fragmented myofibers of the uterine smooth muscle had begun to resemble the normal structure of the lagomorph uterine cavity, arranging in a circular luminal pattern and a longitudinal serosal pattern...
March 25, 2024: Tissue Engineering. Part A
https://read.qxmd.com/read/38524532/quantitative-proteome-and-lysine-succinylome-characterization-of-zinc-chloride-smoke-induced-lung-injury-in-mice
#20
JOURNAL ARTICLE
Rui Zhou, Zhiwei Tu, Daishi Chen, Wanmei Wang, Shuzi Liu, Linjun She, Zhan Li, Jihong Liu, Yabin Li, Yu Cui, Pan Pan, Fei Xie
The inhalation of zinc chloride (ZnCl2 ) smoke is one of common resources of lung injury, potentially resulting in severe pulmonary complications and even mortality. The influence of ZnCl2 smoke on lysine succinylation (Ksucc) in the lungs remains uncertain. In this study, we used a ZnCl2 smoke inhalation mouse model to perform global proteomic and lysine succinylome analyses. A total of 6781 Ksucc sites were identified in the lungs, with injured lungs demonstrating a reduction to approximately 2000 Ksucc sites, and 91 proteins exhibiting at least five differences in the number of Ksucc sites...
March 30, 2024: Heliyon
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