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https://www.readbyqxmd.com/read/28445485/validity-and-reliability-of-the-physical-activity-questionnaire-for-children-paq-c-and-adolescents-paq-a-in-individuals-with-congenital-heart-disease
#1
Christine Voss, Paige H Dean, Ross F Gardner, Stephanie L Duncombe, Kevin C Harris
OBJECTIVE: To assess the criterion validity, internal consistency, reliability and cut-point for the Physical Activity Questionnaire for Children (PAQ-C) and Adolescents (PAQ-A) in children and adolescents with congenital heart disease-a special population at high cardiovascular risk in whom physical activity has not been extensively evaluated. METHODS: We included 84 participants (13.6±2.9 yrs, 50% female) with simple (37%), moderate (31%), or severe congenital heart disease (27%), as well as cardiac transplant recipients (6%), from BC Children's Hospital, Canada...
2017: PloS One
https://www.readbyqxmd.com/read/28445457/the-mitochondrial-na-ca-2-exchanger-is-essential-for-ca-2-homeostasis-and-viability
#2
Timothy S Luongo, Jonathan P Lambert, Polina Gross, Mary Nwokedi, Alyssa A Lombardi, Santhanam Shanmughapriya, April C Carpenter, Devin Kolmetzky, Erhe Gao, Jop H van Berlo, Emily J Tsai, Jeffery D Molkentin, Xiongwen Chen, Muniswamy Madesh, Steven R Houser, John W Elrod
Mitochondrial calcium (mCa(2+)) has a central role in both metabolic regulation and cell death signalling, however its role in homeostatic function and disease is controversial. Slc8b1 encodes the mitochondrial Na(+)/Ca(2+) exchanger (NCLX), which is proposed to be the primary mechanism for mCa(2+) extrusion in excitable cells. Here we show that tamoxifen-induced deletion of Slc8b1 in adult mouse hearts causes sudden death, with less than 13% of affected mice surviving after 14 days. Lethality correlated with severe myocardial dysfunction and fulminant heart failure...
April 26, 2017: Nature
https://www.readbyqxmd.com/read/28445319/intraoperative-cardiac-arrest-a-10-year-study-of-patients-undergoing-tumorous-surgery-in-a-tertiary-referral-cancer-center-in-china
#3
Fei Han, Yufeng Wang, Yue Wang, Jiaxu Dong, Chaoran Nie, Meng Chen, Lina Hou
Intraoperative cardiac arrest (IOCA) is a lethal complication of noncardiac surgery. According to several reports, immediate survival after IOCA is approximately 50%. In this study, a retrospective case analysis was performed to determine the incidence of IOCA, the potential causes of cardiac arrest, and the risk factors of no resuscitation in patients undergoing tumorous surgery.The medical records of surgery patients who experienced cardiac arrest during the intraoperative period between 2005 and 2014 were reviewed...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445175/traumatic-ventral-septal-defect-after-stab-wound-to-the-chest-missed-by-transthoracic-echocardiogram-a-case-report
#4
Abimbola O Faloye, Raphael Y Gershon
Traumatic ventral septal defect may be sustained after either blunt force or penetrating trauma to the chest. Severity ranges from asymptomatic to acute decompensated heart failure. Our patient suffered a stab wound to the chest and was initially taken to the operating room for repair of a lacerated right ventricle. Subsequent postoperative hemodynamic deterioration prompted a bedside transthoracic echocardiogram, which failed to identify causal factors. A transesophageal echocardiogram performed immediately after ventral septal defect was demonstrated...
April 25, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28445087/cardioprotection-by-mild-hypothermia-is-abolished-in-aged-mice
#5
Junjie Guo, Shuning Zhang, Leilei Ma, Hongtao Shi, Jianbing Zhu, Jian Wu, Yi An, Junbo Ge
Mild hypothermia (MH) renders the hearts resistant to ischemia/reperfusion (IR) injury in animal experiments. Unexpectedly, this effect was not observed in recent clinical trials. The aged hearts in mice have been demonstrated to be more susceptible to IR injury. This study aimed to examine whether the cardioprotection of MH was abolished in aged mice. Young (Y, 3 months old) and aged (A, 20 months old) male C57BL/6 mice were randomized into six groups. Sham (Y-SHAM and A-SHAM) and control (Y-CON+IR and A-CON+IR) animals maintained core body temperature at 37°C ± 0...
April 26, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28445003/a-multiscale-approach-for-determining-the-morphology-of-endothelial-cells-at-a-coronary-artery
#6
Hossein Ali Pakravan, Mohammad Said Saidi, Bahar Firoozabadi
The morphology of endothelial cells (ECs) may be an indication for determining the atheroprone sites. Until now, there is not any clinical imaging technique to visualize the morphology of ECs at the arteries. The present study, introduces a computational technique for determining the morphology of ECs. This technique is a multiscale simulation, consisting the artery-scale and the cell-scale. The artery-scale is a FSI simulation. The input for the artery-scale is the geometry of the coronary artery (CA), dynamic curvature of the artery due to the cardiac motion, blood flow, blood pressure, heart rate, and the mechanical properties of the blood and the arterial wall, which these quantities can be obtained for a specific patient...
April 26, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28444995/peripheral-artery-disease-and-risk-of-adverse-outcomes-in-heart-failure-with-preserved-ejection-fraction
#7
Pratik B Sandesara, Muhammad Hammadah, Ayman Samman-Tahhan, Heval M Kelli, Wesley T O'Neal
BACKGROUND: Peripheral artery disease (PAD) in heart failure with preserved ejection fraction (HFpEF) is associated with an increased mortality risk, but the risk of individual outcomes associated with PAD in this patient group is less clear. HYPOTHESIS: PAD is associated with adverse outcomes in HFpEF, including hospitalization and specific cardiovascular outcomes. METHODS: We examined the association between PAD and adverse outcomes in 3385 patients with HFpEF (mean age, 69 ± 9...
April 26, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28444887/morphological-study-of-the-atrioventricular-conduction-system-and-purkinje-fibers-in-yak
#8
Deyong Duan, Sijiu Yu, Yan Cui, Chaoxu Li
We studied the morphology of the atrioventricular conduction system (AVCS) and Purkinje fibers of the yak. Light and transmission electron microscopy were used to study the histological features of AVCS. The distributional characteristics of the His-bundle, the left bundle branch (LBB), right bundle branch (RBB), and Purkinje fiber network of yak hearts were examined using gross dissection, ink injection, and ABS casting. The results showed that the atrioventricular node (AVN) of yak located in the right side of interatrial septum and had a flattened ovoid shape...
April 26, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28444847/complement-dependence-of-murine-costimulatory-blockade-resistant-cellular-cardiac-allograft-rejection
#9
Nicholas Chun, Robert L Fairchild, Yansui Li, Jinhua Liu, Ming Zhang, William M Baldwin, Peter S Heeger
Building upon studies showing that ischemia/reperfusion-(IR)-injury is complement-dependent, we tested links among complement activation, transplant associated ischemia-reperfusion injury, and murine cardiac allograft rejection. We transplanted BALB/c hearts subjected to 8h cold ischemic storage (CIS) into CTLA4Ig-treated WT or c3(-/-) B6 recipients. Whereas allografts subjected to 8h CIS rejected in WT recipients with a median survival time (MST) of 37d, identically treated hearts survived >60d in c3(-/-) mice (p<0...
April 26, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28444807/rkip-lessons-of-a-better-way-for-%C3%AE-adrenergic-receptor-activation-in-the-heart
#10
Kristina Lorenz, Marsha Rich Rosner, Theresa Brand, Joachim P Schmitt
Stimulation of β-adrenergic receptors (βAR) provides the most efficient physiological mechanism to enhance contraction and relaxation of the heart. Activation of βAR allows rapid enhancement of myocardial function in order to fuel the muscles for running and fighting in a fight-or-flight response. Likewise, βAR get activated during cardiovascular disease in an attempt to counteract the restrictions of cardiac output. However, long-term stimulation of βAR increases the likelihood of cardiac arrhythmias, adverse ventricular remodelling, decline of cardiac performance and premature death, thereby limiting the use of βAR agonists in the treatment of heart failure...
April 26, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28444256/outcomes-after-the-mustard-senning-and-arterial-switch-operation-for-treatment-of-transposition-of-the-great-arteries-in-finland-a-nationwide-4-decade-perspective
#11
Alireza Raissadati, Heta Nieminen, Heikki Sairanen, Eero Jokinen
OBJECTIVES: We analysed nationwide early and late results after the Mustard, Senning and arterial switch operation. METHODS: We included all paediatric patients (<18 years) who underwent a Senning, a Mustard or an arterial switch operation for transposition of the great arteries from 1968 to 2009 in Finland. Data were obtained retrospectively from a paediatric cardiac surgical database and population data from the Finnish national registry. RESULTS: Early mortality (<30 days) was 11% after Mustard and 5% after Senning operation, while the rate decreased from 19% during 1976-1999 to 2% during 2000-2009 for arterial switch patients ( P  < 0...
April 24, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28444178/shortening-cardioplegic-arrest-time-in-patients-undergoing-combined-coronary-and-valve-surgery-results-from-a-multicentre-randomized-controlled-trial-the-scat-trial
#12
Chris A Rogers, Radek Capoun, Lauren J Scott, Jodi Taylor, Anil Jain, Gianni D Angelini, Pradeep Narayan, M-Saadeh Suleiman, Kunal Sarkar, Raimondo Ascione
OBJECTIVES: Combined coronary artery bypass grafting and valve surgery requires a prolonged period of cardioplegic arrest (CA) predisposing to myocardial injury and postoperative cardiac-specific complications. The aim of this trial was to reduce the CA time in patients undergoing combined coronary artery bypass grafting and valve surgery and assess if this was associated with less myocardial injury and related complications. METHODS: Participants were randomized to (i) coronary artery bypass grafting performed on the beating heart with cardiopulmonary bypass support followed by CA for the valve procedure (hybrid) or (ii) both procedures under CA (conventional)...
April 24, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28444174/catheter-ablation-for-ventricular-tachycardia-in-patients-with-cardiac-sarcoidosis-a-systematic-review
#13
Nikolaos Papageorgiou, Rui Providência, Konstantinos Bronis, Dirk G Dechering, Neil Srinivasan, Lars Eckardt, Pier D Lambiase
Aims: Cardiac sarcoidosis (CS) is associated with a poor prognosis. Important features of CS include heart failure, conduction abnormalities, and ventricular arrhythmias. Ventricular tachycardia (VT) is often refractory to antiarrhythmic drugs (AAD) and immunosuppression. Catheter ablation has emerged as a treatment option for recurrent VT. However, data on the efficacy and outcomes of VT ablation in this context are sparse. Methods and results: A systematic search was performed on PubMed, EMBASE, and Cochrane database (from inception to September 2016) with included studies providing a minimum of information on CS patients undergoing VT ablation: age, gender, VT cycle length, CS diagnosis criteria, and baseline medications...
April 21, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28444068/acute-bag-valve-breathing-maneuvers-plus-manual-chest-compression-is-safe-during-stable-septic-shock-a-randomized-clinical-trial
#14
Clarissa Netto Blattner, Rafael Saldanha Dos Santos, Fernando Suparregui Dias, Alexandre Simões Dias, Régis Gemerasca Mestriner, Silvia Regina Rios Vieira
Objective: To evaluate the effects of bag-valve breathing maneuvers combined with standard manual chest compression techniques on safety, hemodynamics and oxygenation in stable septic shock patients. Design: A parallel, assessor-blinded, randomized trial of two groups. A computer-generated list of random numbers was prepared by an independent researcher to allocate treatments. Setting: The Intensive Care Unit at Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul...
January 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28443680/periodic-breathing-during-incremental-exercise
#15
Piergiuseppe Agostoni, Ugo Corrà, Michele Emdin
Periodic breathing during incremental cardiopulmonary exercise testing is a regularly recurring waxing and waning of tidal volume due to oscillations in central respiratory drive. Periodic breathing is a sign of respiratory control system instability, which may occur at rest or during exercise. The possible mechanisms responsible of exertional periodic breathing might be related to any instability of the ventilatory regulation caused by: 1) increased circulatory delay (i.e., circulation time from the lung to the brain and chemoreceptors, due to reduced cardiac index leading to delay in information transfer), 2) increase in controller gain (i...
April 26, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28443594/diastolic-electrocardiographic-parameters-predict-implantable-device-detected-asymptomatic-atrial-fibrillation
#16
Ahmet İlker Tekkeşin, Yalçın Velibey, Ceyhan Türkkan, Ahmet Taha Alper, Yasin Çakıllı, Tolga Sinan Güvenç, Ozan Tanık, Adnan Kaya, Özlem Yıldırımtürk, Nazmiye Özbilgin, Özge Güzelburç, Ahmet Öz, Regayip Zehir, Kadir Gürkan
BACKGROUND: Atrial fibrillation (AF) is the most common clinically significant arrhythmia. It is now established that atrial high rate episodes (AHRE) correlate highly with AF. AIMS: Present study aimed to investigate the relation between diastolic electrocardiographic parameters and subclinical AF detected by cardiac implantable electronic devices. STUDY DESIGN: This study was cross-sectional study that included a total of 203 patients who had a DDDR pacemaker due to sinus node dysfunction...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28443376/remote-ischemic-conditioning-and-renal-protection
#17
Georgios Giannopoulos, Dimitrios A Vrachatis, Vasiliki Panagopoulou, Manolis Vavuranakis, Michael W Cleman, Spyridon Deftereos
Over the course of the last 2 decades, the concept of remote ischemic conditioning (RIC) has attracted considerable research interest, because RIC, in most of its embodiments offers an inexpensive way of protecting tissues against ischemic damage inflicted by a number of medical conditions or procedures. Acute kidney injury (AKI) is a common side effect in the context of various medical procedures, and RIC has been suggested as a means of reducing its incidence. Outcomes regarding kidney function have been reported in numerous studies that evaluated the effects of RIC in a variety of settings (eg, cardiac surgery, interventions requiring intravenous administration of contrast media)...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28442930/thoracic-epidural-analgesia-reduces-myocardial-injury-in-ischemic-patients-undergoing-major-abdominal-cancer-surgery
#18
Mohamad Farouk Mohamad, Montaser A Mohammad, Diab F Hetta, Eman Hasan Ahmed, Ahmed A Obiedallah, Alaa Ali M Elzohry
BACKGROUND AND OBJECTIVES: Major abdominal cancer surgeries are associated with significant perioperative mortality and morbidity due to myocardial ischemia and infarction. This study examined the effect of perioperative patient controlled epidural analgesia (PCEA) on occurrence of ischemic cardiac injury in ischemic patients undergoing major abdominal cancer surgery. PATIENTS AND METHODS: One hundred and twenty patients (American Society of Anesthesiologists grade II and III) of either sex were scheduled for elective upper gastrointestinal cancer surgeries...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28442772/discriminative-and-distinct-phenotyping-by-constrained-tensor-factorization
#19
Yejin Kim, Robert El-Kareh, Jimeng Sun, Hwanjo Yu, Xiaoqian Jiang
Adoption of Electronic Health Record (EHR) systems has led to collection of massive healthcare data, which creates oppor- tunities and challenges to study them. Computational phenotyping offers a promising way to convert the sparse and complex data into meaningful concepts that are interpretable to healthcare givers to make use of them. We propose a novel su- pervised nonnegative tensor factorization methodology that derives discriminative and distinct phenotypes. We represented co-occurrence of diagnoses and prescriptions in EHRs as a third-order tensor, and decomposed it using the CP algorithm...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442712/cardioprotective-effects-of-cu-ii-atsm-in-human-vascular-smooth-muscle-cells-and-cardiomyocytes-mediated-by-nrf2-and-dj-1
#20
Salil Srivastava, Philip J Blower, Aisah A Aubdool, Robert C Hider, Giovanni E Mann, Richard C Siow
Cu((II))ATSM was developed as a hypoxia sensitive positron emission tomography agent. Recent reports have highlighted the neuroprotective properties of Cu((II))ATSM, yet there are no reports that it confers cardioprotection. We demonstrate that Cu((II))ATSM activates the redox-sensitive transcription factor Nrf2 in human coronary artery smooth muscle cells (HCASMC) and cardiac myocytes (HCM), leading to upregulation of antioxidant defense enzymes. Oral delivery of Cu((II))ATSM in mice induced expression of the Nrf2-regulated enzymes in the heart and aorta...
December 21, 2016: Scientific Reports
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