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https://www.readbyqxmd.com/read/28965741/novel-biomarkers-for-sepsis-a-narrative-review
#1
Frederik Fruergaard Larsen, J Asger Petersen
BACKGROUND: Sepsis is a prevalent condition among hospitalized patients that carries a high risk of morbidity and mortality. Rapid recognition of sepsis as the cause of deterioration is desirable, so effective treatment can be initiated rapidly. Traditionally, diagnosis was based on presence of two or more positive SIRS criteria due to infection. However, recently published sepsis-3 criteria put more emphasis on organ dysfunction caused by infection in the definition of sepsis. Regardless of this, no gold standard for diagnosis exist, and clinicians still rely on a number of traditional and novel biomarkers to discriminate between patients with and without infection, as the cause of deterioration...
September 28, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28919353/presepsin-a-new-marker-of-catheter-related-blood-stream-infections-in-pediatric-patients
#2
Sevgen Tanır Basaranoglu, Eda Karadag-Oncel, Kubra Aykac, Yasemin Ozsurekci, Ahmet Emre Aycan, Ali Bulent Cengiz, Ates Kara, Mehmet Ceyhan
BACKGROUND: Catheter related blood stream infections (CRBSI) are mostly preventable hospital-acquired conditions. We aimed to investigate the value of presepsin in detection of CRBSI in hospitalized children. METHODS: Hospitalized pediatric patients who had clinical suspicion of CRBSI were followed. Results of peripheral blood cultures and blood cultures from central venous catheters, procalcitonin (PCT), C-reactive protein (CRP), total white blood cell (WBC) counts were recorded...
September 14, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28911289/incidence-of-elevated-procalcitonin-and-presepsin-levels-after-severe-trauma-a-pilot-cohort-study
#3
K Hoshino, Y Irie, M Mizunuma, K Kawano, T Kitamura, H Ishikura
Procalcitonin (PCT) and presepsin (PSEP) are useful biomarkers for diagnosing sepsis; however, elevated PCT and PSEP levels may be observed in conditions other than sepsis. We hypothesised that PCT and PSEP levels could increase after severe traumatic injuries. Trauma patients with an Injury Severity Score of ≥16 from October 2013 to September 2015 were enrolled in our study. We examined PCT and PSEP levels and their positive rates on days 0 and 1. PCT and PSEP levels on days 0 and 1 were compared. Risk factors for increasing sepsis biomarker levels were identified by multivariate logistic regression analyses...
September 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28905041/presepsin-scd14-st-could-it-be-a-novel-marker-for-the-diagnosis-of-st-elevation-myocardial-infarction
#4
Fatma Nihan Turhan Caglar, Nilgun Isiksacan, Ismail Biyik, Selcuk Opan, Hulya Cebe, Ibrahim Faruk Akturk
INTRODUCTION: Acute myocardial infarction (AMI) could be considered to be a state of inflammation. Many inflammatory markers have been evaluated in the AMI setting so far. Presepsin (PSP) is a novel biomarker for diagnosis and prognosis of systemic inflammation that has not been studied in the AMI setting to date. In this study, we aimed to examine serum PSP levels in patients with acute ST elevation myocardial infarction (STEMI). MATERIAL AND METHODS: Forty-eight patients with STEMI and fifty healthy controls without coronary artery disease, verified by coronary angiography, were included in the study...
2017: Arch Med Sci Atheroscler Dis
https://www.readbyqxmd.com/read/28886956/sepsis-biomarkers-reprofiling-to-predict-stroke-associated-infections
#5
Alejandro Bustamante, Teresa García-Berrocoso, Anna Penalba, Dolors Giralt, Alba Simats, Marian Muchada, Elena Zapata, Marta Rubiera, Joan Montaner
We aimed to evaluate the usefulness of sepsis biomarkers to predict stroke-associated infections. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), mid-regional pro-adrenomedullin (MR-proADM), presepsin (sCD14), and soluble urokinase-type plasminogen activator receptor (suPAR), were explored in 125 blood samples collected at different time-points. At baseline, MR-proADM was an independent predictor of infection [>0.94pg/mL, OR=3.63 (1.16-11.33), p=0.026], as well as suPAR at 24h [>2185...
November 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28875483/comparison-of-diagnostic-accuracy-in-sepsis-between-presepsin-procalcitonin-and-c-reactive-protein-a-systematic-review-and-meta-analysis
#6
Chin-Chieh Wu, Hao-Min Lan, Shih-Tsung Han, Chung-Hsien Chaou, Chun-Fu Yeh, Su-Hsun Liu, Chih-Huang Li, Gerald N Blaney, Zhen-Ying Liu, Kuan-Fu Chen
BACKGROUND: The soluble cluster of differentiation 14 (or presepsin) is a free fragment of glycoprotein expressed on monocytes and macrophages. Although many studies have been conducted recently, the diagnostic performance of presepsin for sepsis remains debated. We performed a systematic review and meta-analysis of the available literature to assess the accuracy of presepsin for the diagnosis of sepsis in adult patients and compared the performance between presepsin, C-reactive protein (CRP), and procalcitonin (PCT)...
September 6, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28816823/postoperative-changes-in-presepsin-level-and-values-predictive-of-surgical-site-infection-after-spinal-surgery-a-single-center-prospective-observational-study
#7
Tomoaki Koakutsu, Tetsuya Sato, Toshimi Aizawa, Eiji Itoi, Shigeki Kushimoto
STUDY DESIGN: Single-institutional, prospective observational study. OBJECTIVE: To elucidate the perioperative kinetics of presepsin (PSEP) in patients undergoing spinal surgery, and to evaluate the possibility of PSEP in the early diagnosis of surgical site infection (SSI). SUMMARY OF BACKGROUND DATA: Early diagnosis of SSI after spinal surgery is important. Although several biomarkers have been used as early indicators of SSI, the specificity of these markers in SSI diagnosis was not high...
August 14, 2017: Spine
https://www.readbyqxmd.com/read/28795679/-research-progress-of-presepsin-in-sepsis-diagnosis
#8
Hui Yu, Yuanlin Zeng, Congyang Zhou
Sepsis is a frequently met syndrome with complex clinical symptoms and high mortality in emergency department. Early diagnosis of sepsis and timely treatment can improve survival. In recent years, the application of biomarkers [such as procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6)] are commonly used in the early diagnosis of sepsis, but their specificity and sensitivity are limited because of the long lag of report time. Soluble leukocyte differentiation antigen 14 sub type (sCD14-ST, namely presepsin) is a kind of novel biomarkers...
August 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28757820/nonconventional-markers-of-sepsis
#9
Péter Kustán, Zoltán Horváth-Szalai, Diána Mühl
Sepsis still remains a challenging healthcare problem with high mortality rate. To improve outcome, early diagnosis and monitoring of sepsis is of utmost importance. In this process objective laboratory parameters are the most helpful. Procalcitonin and C-reactive protein are the most commonly used and recommended markers of sepsis however, more than 200 sepsis biomarkers have already been published. This mini review focuses on nonconventional novel possibilities for the recognition of sepsis severity. Presepsin, actin and actin scavenger proteins (gelsolin and Gc-globulin) and orosomucoid are discussed...
May 2017: EJIFCC
https://www.readbyqxmd.com/read/28757819/advances-and-pitfalls-in-using-laboratory-biomarkers-for-the-diagnosis-and-management-of-sepsis
#10
Dunja Rogić, Gordana Fressl Juroš, József Petrik, Ana Lončar Vrančić
Sepsis is a critical patient condition with high mortality rate caused by a complex and inadequate host response to infection. Since early identification and start of antibiotic therapy in the first few hours after sepsis development dramatically improves outcomes, it is of utter importance to offer fast, reliable and specific early laboratory biomarkers to help clinicians in sepsis recognition. On the other hand, the biomarkers should also be helpful in excluding sepsis and/or confirming therapy effectiveness, and thus prevent overprescribing of antibiotics...
May 2017: EJIFCC
https://www.readbyqxmd.com/read/28641717/soluble-cd14-subtype-a-new-biomarker-in-predicting-the-outcome-of-critically-ill-septic-patients
#11
Giovanni Matera, Angela Quirino, Cinzia Peronace, Pio Settembre, Vito Marano, Maria T Loria, Nadia Marascio, Luisa Galati, Giorgio S Barreca, Aida Giancotti, Bruno Amantea, Maria C Liberto, Alfredo Focà
BACKGROUND: We evaluated the role of presepsin (soluble CD14 subtype, sCD14-ST) in predicting the outcome of critically ill septic patients in parallel with procalcitonin and C-reactive protein. METHODS: This study was an observational, prospective study that enrolled 58 surgical and medical intensive care unit patients with suspected sepsis. All studied subjects were retrospectively stratified into survivors and nonsurvivors based on 28 days survival and according to microbiological results in blood culture positive and negative groups...
June 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28502138/presepsin-a-diagnostic-marker-for-sepsis-in-intensive-care-unit-patients
#12
Hanaa A Amer, Hala Ghareeb, Neama M Lotfy, Noran O El-Azizi, Asmaa Mahmoud Mahmoud
The aim of the study was to evaluate the usefulness of presepsin as a diagnostic marker of sepsis in intensive care unit (ICU) patients. Presepsin was measured by a rapid method based on a chemiluminescent enzyme immunoassay (PATHFAST). The clinical usefulness of presepsin to diagnose sepsis and septic shock was studied and compared with procalcitonin, C-reactive protein and total leucocytic count. This study was conducted on 53 individuals divided into 3 groups. Group I included 28 adult ICU patients with at least two diagnostic criteria for systemic inflammatory response syndrome (SIRS) as patient group, Group IIa 15 patients admitted to ICU for any medical cause but with no evidence of infection were enrolled as patient control group and further 10 apparently healthy subjects as healthy control group...
June 2016: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/28502131/diagnostic-value-of-presepsin-in-neonatal-sepsis
#13
Hala AbdEL-Mageed Tabl, Neveen Tawfik Abed
Presepsin has recently been described as biomarker of sepsis. The aim of this study was to investigate the diagnostic accuracy of presepsin in diagnosing neonatal sepsis and discriminating sepsis from non-infectious systemic inflammatory response syndrome (SIRS). The study included 70 full term neonates divided into three groups: 1) Sepsis group (22 patients with clinically suspected sepsis and positive blood cultures) 2) Non-infectious SIRS group (28 patients with clinically suspected sepsis and persistently negative blood cultures) 3) Control group (20 healthy neonates without any clinical signs of infection)...
June 2016: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/28487809/the-level-of-oxidative-neutrophil-response-when-determining-endotoxin-activity-assay-a-new-biomarker-for-defining-the-indications-and-effectiveness-of-intensive-care-in-patients-with-sepsis
#14
Michael Yaroustovsky, Ekaterina Rogalskaya, Marina Plyushch, Ludmila Klimovich, Nataliya Samsonova, Marina Abramyan
Background. To analyse the clinical informativity of the neutrophil oxidative response level ("Response") during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). The composite of laboratory studies included CRP, PCT, EAA with "Response" level, and presepsin...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28432884/use-of-presepsin-and-procalcitonin-for-prediction-of-septifast-results-in-critically-ill-patients
#15
Dunja Mihajlovic, Snezana Brkic, Arsen Uvelin, Biljana Draskovic, Vladimir Vrsajkov
PURPOSE: There is a need for identification of marker that could lead physicians to take the right step towards laboratory techniques for documentation of infection. The aim of this study was to investigate whether presepsin and procalcitonin (PCT) levels in patients with suspected sepsis could predict blood culture (BC) and SeptiFast (SF) results. MATERIAL AND METHODS: 100 patients were included in our study. PCT, C-reactive protein (CRP), and presepsin levels were determined...
August 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28431809/pilot-study-of-changes-in-presepsin-concentrations-compared-with-changes-in-procalcitonin-and-c-reactive-protein-concentrations-after-cardiovascular-surgery
#16
Junichi Saito, Eiji Hashiba, Akio Mikami, Tomoyuki Kudo, Hidetomo Niwa, Kazuyoshi Hirota
OBJECTIVE: The authors investigated the presepsin-concentration profile after cardiac surgery compared with those of procalcitonin (PCT) and C-reactive protein (CRP). DESIGN: A single-center, prospective, observational clinical study. SETTING: Hirosaki University Hospital. PARTICIPANTS: Patients who underwent cardiovascular surgery without preoperative infection and end-stage kidney disease requiring dialysis. The patients also were subdivided into 2 groups with respect to the use of cardiopulmonary bypass (CPB)...
August 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28278703/diagnostic-usefulness-of-plasma-presepsin-soluble-cd14-subtype-for-diagnosing-hemophagocytic-syndrome-in-hematological-malignancies
#17
Hideo Koh, Satoru Nanno, Takako Katayama, Asao Hirose, Mika Nakamae, Masayuki Hino, Hirohisa Nakamae
No abstract text is available yet for this article.
February 28, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28271449/multi-marker-approach-using-procalcitonin-presepsin-galectin-3-and-soluble-suppression-of-tumorigenicity-2-for-the-prediction-of-mortality-in-sepsis
#18
Hanah Kim, Mina Hur, Hee-Won Moon, Yeo-Min Yun, Salvatore Di Somma
BACKGROUND: Biomarker could be objective and reliable tools to predict mortality in sepsis. We explored the prognostic utilities of emerging biomarkers in septic patients and questioned whether adding biomarkers to the clinical variables would improve the prediction of mortality in sepsis. METHODS: This retrospective study included 157 septic patients (112 patients with sepsis; 45 patients with septic shock). Procalcitonin (PCT), presepsin, galectin-3, and soluble suppression of tumorigenicity 2 (sST2) concentrations were analyzed in relation to the 30-day all-cause mortality...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28264831/head-to-head-comparison-of-procalcitonin-and-presepsin-for-the-diagnosis-of-sepsis-in-critically-ill-adult-patients-a-protocol-for-a-systematic-review-and-meta-analysis
#19
Kei Hayashida, Yutaka Kondo, Yoshitaka Hara, Morio Aihara, Kazuma Yamakawa
INTRODUCTION: Early diagnosis and immediate therapeutic intervention, including appropriate antibiotic therapy and goal-directed resuscitation, are necessary to reduce mortality in patients with sepsis. However, a single clinical or biological marker indicative of sepsis has not been adopted unanimously. Although procalcitonin and presepsin are promising biomarkers that can effectively differentiate between sepsis/infection and systemic inflammatory response syndrome of non-infectious origin, little is known about which marker is superior...
March 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28264059/biomarker-based-diagnosis-of-pacemaker-and-implantable-cardioverter-defibrillator-pocket-infections-a-prospective-multicentre-case-control-evaluation
#20
MULTICENTER STUDY
Carsten Lennerz, Hrvoje Vrazic, Bernhard Haller, Siegmund Braun, Tobias Petzold, Ilka Ott, Agnes Lennerz, Jonathan Michel, Patrick Blažek, Isabel Deisenhofer, Peter Whittaker, Christof Kolb
BACKGROUND: The use of cardiac implantable electronic devices (CIED) has risen steadily, yet the rate of cardiac device infections (CDI) has disproportionately increased. Amongst all cardiac device infections, the pocket infection is the most challenging diagnosis. Therefore, we aimed to improve diagnosis of such pocket infection by identifying relevant biomarkers. METHODS: We enrolled 25 consecutive patients with invasively and microbiologically confirmed pocket infection...
2017: PloS One
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