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Maria Papp, Tamas Tornai, Zsuzsanna Vitalis, Istvan Tornai, David Tornai, Tamas Dinya, Andrea Sumegi, Peter Antal-Szalmas
AIM: To evaluate the diagnostic and prognostic value of presepsin in cirrhosis-associated bacterial infections. METHODS: Two hundred and sixteen patients with cirrhosis were enrolled. At admission, the presence of bacterial infections and level of plasma presepsin, serum C-reactive protein (CRP) and procalcitonin (PCT) were evaluated. Patients were followed for three months to assess the possible association between presepsin level and short-term mortality. RESULTS: Present 34...
November 7, 2016: World Journal of Gastroenterology: WJG
Yann-Erick Claessens, Eloise Trabattoni, Sophie Grabar, Laurent Quinquis, Guillaume Der Sahakian, Marine Anselmo, Jeannot Schmidt, Jean-Emmanuel de la Coussaye, Patrick Plaisance, Enrique Casalino, Gilles Potel, François Lecomte, Didier Borderie, Camille Chenevier-Gobeaux
INTRODUCTION: Presepsin (sCD14-ST) is an emerging biomarker for infection. We hypothesized that presepsin could specifically increase during acute pyelonephritis and correlate with severity. METHODS: We compared presepsin values in patients with acute pyelonephritis and controls, and we assessed its capacity to predict bacteraemia and admission in patients. RESULTS: In 312 patients with acute pyelonephritis (median age 33years), presepsin concentrations were higher than in controls (476 vs 200ng/L, p<0...
November 24, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Ali Ovayolu, Cansev Yilmaz Arslanbuğa, Ismet Gun, Belgin Devranoglu, Arman Ozdemir, Sule Eren Cakar
OBJECTIVE: To determine whether semen and plasma presepsin values measured in men with normozoospermia and oligoasthenospermia undergoing invitro-fertilization would be helpful in predicting ongoing pregnancy and live birth. METHODS: Group-I was defined as patients who had pregnancy after treatment and Group-II comprised those with no pregnancy. Semen and blood presepsin values were subsequently compared between the groups. Parametric comparisons were performed using Student's t-test, and non-parametric comparisons were conducted using the Mann-Whitney U test...
September 2016: Pakistan Journal of Medical Sciences Quarterly
Janka Franeková, Peter Sečník, Petra Lavríková, Zdenek Kubíček, Lenka Hošková, Eva Kieslichová, Antonín Jabor
Differentiation between systemic inflammatory response syndrome (SIRS) and sepsis in surgical patients is of crucial significance. Procalcitonin (PCT) and C-reactive protein (CRP) are widely used biomarkers, but PCT becomes compromised after antithymocyte globulin (ATG) administration, and CRP exhibits limited specificity. Presepsin has been suggested as an alternative biomarker of sepsis. This study aims to demonstrate the role of presepsin in patients after heart transplantation (HTx). Plasma presepsin, PCT and CRP were measured in 107 patients serially for up to 10 days following HTx...
November 16, 2016: Clinical Transplantation
Kentaro Tokuda, Jun Maki, Noriyuki Kaku, Soichi Mizuguchi, Mitsuhiro Fukata, Tomohiko Akahoshi, Sumio Hoka, Yoshihiko Maehara
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Jana Hudcova, Debra Poutsiaka, Maryam Khan, Ahsan Waqas, Christopher Homsy, Stanley Nasraway
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Abdurrahman A Ozdemir, Yusuf Elgormus
Objective The aim of this study was to evaluate the efficacy of presepsin in both diagnosis and follow-up of early-onset neonatal sepsis (EOS) and also to compare its effectiveness with C-reactive protein (CRP) and procalcitonin (PCT). Methods A total of 29 term infants with EOS group and 40 term infants with control group were included in this study. Before initiating therapy, blood samples for whole blood count, CRP, PCT, presepsin, and culture were obtained from all neonates (T0). This procedure was repeated two times at 72 hours (T3) and day 7 (T7)...
November 8, 2016: American Journal of Perinatology
Luis García de Guadiana Romualdo, Patricia Esteban Torrella, Sergio Rebollo Acebes, María Dolores Albaladejo Otón, Roberto Jiménez Sánchez, Ana Hernando Holgado, Enrique Jiménez Santos, Alejandro Ortín Freire
BACKGROUND: Presepsin is a promising biomarker for the diagnosis and prognosis of sepsis. However, results reported about its value to diagnose sepsis in an emergency department (ED) are controversial, probably due to differences in the design of the studies. We have evaluated the diagnostic accuracy of presepsin for infection and sepsis, compared with procalcitonin (PCT) and C-reactive protein (CRP), in patients presenting to the emergency department (ED) with suspected infection. METHODS: 223 patients with suspected infection were enrolled for the study...
November 4, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Igor Stoma, Igor Karpov, Anatoly Uss, Oleg Rummo, Natalia Milanovich, Igor Iskrov
OBJECTIVE/BACKGROUND: A decision about the need for antimicrobial therapy in a patient with febrile neutropenia after hematopoietic stem cell transplantation (HSCT) is often complicated because of the low frequency of culture isolation and reduced clinical manifestation of infection. Usefulness and choice of sepsis biomarkers to distinguish bloodstream infection (BSI) from other causes of febrile episode is still argued in HSCT recipients in modern epidemiological situations characterized by the emergence of highly resistant gram-negative microorganisms...
October 20, 2016: Hematology/oncology and Stem Cell Therapy
Soichiro Tsuji, Ayako Kitatoube, Akie Kikuchi-Taura, Eri Oguro, Minoru Shigesaka, Yasutaka Okita, Takashi Shimizu, Takuro Nii, Satoru Teshigawara, Eriko Tanaka, Yoshinori Harada, Masato Matsushita, Jun Hashimoto, Shiro Ohshima, Gaku Takahashi, Shigeatsu Endo, Yukihiko Saeki
No abstract text is available yet for this article.
October 27, 2016: Modern Rheumatology
Jiri Parenica, Jiri Jarkovsky, Jan Malaska, Alexandre Mebazaa, Jana Gottwaldova, Katerina Helanova, Jiri Litzman, Milan Dastych, Josef Tomandl, Jindrich Spinar, Ludmila Dostalova, Petr Lokaj, Marie Tomandlova, Monika Goldergova Pavkova, Pavel Sevcik, Matthieu Legrand
INTRODUCTION: Cardiogenic shock (CS) patients are at a high risk of developing infectious complications; however, their early detection is difficult, mainly due to a frequently occurring non-infectious inflammatory response, which accompanies an extensive myocardial infarction or a post-cardiac arrest syndrome. The goal of our prospective study was to describe infectious complications in CS and the immune/inflammatory response based on a serial measurement of several blood-based inflammatory biomarkers...
September 29, 2016: Shock
Satoru Nanno, Hideo Koh, Takako Katayama, Masamichi Hashiba, Ayumi Sato, Yosuke Makuuchi, Joji Nagasaki, Masatomo Kuno, Takuro Yoshimura, Hiroshi Okamura, Mitsutaka Nishimoto, Asao Hirose, Mika Nakamae, Takahiko Nakane, Masayuki Hino, Hirohisa Nakamae
Objective Recent studies suggest that presepsin (soluble CD14-subtype) is a useful diagnostic and prognostic marker for sepsis, with secretion by activated macrophages potentially dependent on phagocytosis of microorganisms. As "hemophagocytosis" is one of the major characteristics in patients with hemophagocytic syndrome (HPS), we hypothesized that presepsin may reflect the phagocytic activity and be a useful prognostic marker for HPS. Therefore, we aimed to assess the prognostic potential of presepsin in secondary HPS in adult patients with hematological malignancies...
2016: Internal Medicine
X Gao, B Y Zhu, W Z Wang, J Q He, D L Han, Y J Liu, H Meng, Q M Xiao, X T Liu, Y Y Han
OBJECTIVE: To investigate the value of serum presepsin concentration measurement in the clinical diagnosis and treatment of patients with pesticide poisoning patients. METHODS: A total of 160 patients with pesticide poisoning were enrolled as study subjects and divided into moderate organophosphate pesticide poisoning group (40 patients) , severe organophosphate pesticide poisoning group (40 patients) , abamectin pesticide poisoning group (40 patients) , and paraquat poisoning group (40 patients)...
May 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
Xiaofei Song, Yucheng Song, Yuan Yuan, Peng Zhang, Xuedong Zhang
BACKGROUND: Enterocutaneous fistula (ECF) poses a supreme challenge for the surgeons associated with abdominal sepsis, fluid electrolyte imbalance and undernutrition. Individual prognostic stratification is pivotal in the clinical management. Presepsin is a novel biomarker showing diagnostic and prognostic value in sepsis. We aimed to evaluate the prognostic value of presepsin in ECF. METHODS: Consecutive patients with ECF were enrolled if diagnosed as abdominal sepsis from June 2014 to June 2015...
September 2016: International Journal of Surgery
Gaku Takahashi, Shigehiro Shibata, Yasuo Fukui, Yoshikazu Okamura, Yoshihiro Inoue
Procalcitonin (PCT) and presepsin (PSEP) are sepsis markers, but their diagnostic accuracy may be compromised in acute kidney injury (AKI). We evaluated their diagnostic accuracy in patients with/without AKI. This retrospective study comprised 91 patients with at least one criterion of systematic inflammatory response syndrome. AKI markers plasma neutrophil gelatinase-associated lipocalin (NGAL), plasma cystatin C (CysC), and estimated glomerular filtration rate (eGFR) were measured upon hospital admission and on days 1, 3, 5, and 7...
October 2016: Diagnostic Microbiology and Infectious Disease
M Plesko, J Suvada, M Makohusova, I Waczulikova, D Behulova, A Vasilenkova, M Vargova, A Stecova, E Kaiserova, A Kolenova
Bacterial infection is the most common complication in paediatric oncological patients during cancer treatment. A suitable tool for early prediction of unfavourable course of infection is still needed. We performed a prospective longitudinal observational study to evaluate of the role of serum biomarkers (C-reactive protein, procalcitonin, interleukin-6, presepsin) in the early diagnosis of bacteraemia (gram-negative versus gram-positive) in patients with haematological malignancies. We observed 69 febrile episodes in 33 patients (17 male, 16 female; 1...
2016: Neoplasma
Kada Klouche, Jean Paul Cristol, Julie Devin, Vincent Gilles, Nils Kuster, Romaric Larcher, Laurent Amigues, Philippe Corne, Olivier Jonquet, Anne Marie Dupuy
BACKGROUND: The soluble CD14 subtype, Presepsin, appears to be an accurate sepsis diagnostic marker, but data from intensive care units (ICUs) are scarce. This study was conducted to evaluate the diagnostic and prognostic value of Presepsin in ICU patients with severe sepsis (SS), septic shock (SSh) and severe community-acquired pneumonia (sCAP). METHODS: Presepsin and procalcitonin (PCT) levels were determined for patients at admission to ICU. Four groups have been differentiated: (1) absence or (2) presence of systemic inflammatory response syndrome, (3) SS or (4) SSh; and 2 groups, among the patients admitted for acute respiratory failure: absence or presence of sCAP...
December 2016: Annals of Intensive Care
Fahmy T Ali, Mohamed A M Ali, Mostafa M Elnakeeb, Heba N M Bendary
Despite their undoubted helpfulness in diagnosing sepsis, increased blood C-reactive protein (CRP) and procalcitonin (PCT) levels have been described in many noninfectious conditions. Presepsin is a soluble fragment of the cluster of differentiation 14 involved in pathogen recognition by innate immunity. We aimed to investigate the diagnostic and prognostic performance of presepsin in comparison to PCT and CRP in patients presenting with systemic inflammatory response syndrome (SIRS) and suspected sepsis. Seventy-six subjects were enrolled in this study, including 51 patients with SIRS as well as 25 healthy subjects...
September 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Kohei Tsujimoto, Atsuko Hata, Masaaki Fujita, Saori Hatachi, Masato Yagita
AIM: To assess the diagnostic values of presepsin and procalcitonin in patients with rheumatoid arthritis (RA) by identifying those with bacterial infection METHOD: During June 2014-September 2015, 126 patients with RA and 25 healthy controls were enrolled. RA patients were divided into an infection group and a non-infection group. Infection was diagnosed by clinical symptoms, microbiological or radiographic methods, and good response to antibiotics. Concentrations of plasma presepsin, serum procalcitonin, C-reactive protein (CRP), and white blood cell counts (WBC) were measured and compared in each group...
June 13, 2016: International Journal of Rheumatic Diseases
O V Rotar
In 70 patients, suffering an acute necrotic pancreatitis (ANP), and 10 practically healthy persons a content of presepsin in a blood plasm, using immunochemiluminescent method and conducted bacteriological investigations, were analyzed. The infection occurrence is accompanied by plausible upgrading of a presepsin level in a blood plasm, depending on activity and severity of a septic process: in local infection--up to (677 ± 30) pg/ml, sepsis--up to (988 ± 47) pg/ml, severe sepsis--up to 2668 pg/ml; in an ANP without infection it have constituted (332 ± 38) pg/mI at average, in practically healthy persons--(184 ± 16) pg/mI...
January 2016: Klinichna Khirurhiia
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