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Presepsin

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https://www.readbyqxmd.com/read/28164588/elevated-presepsin-levels-are-associated-with-severity-and-prognosis-of-severe-acute-pancreatitis
#1
Jianbo Lin, Zhe Li, Yanhong Zheng, Yang Zhang, Cunhua Shao, Gongpan Liu, Jiangong Li
BACKGROUND: Current clinical scoring systems are insufficient in the early identification of severe acute pancreatitis (SAP) patients at risk of developing potentially lethal complications. This present study was designed to evaluate the relationship of presepsin with disease severity, local complications, organ failure, and mortality of SAP. METHODS: Eighty-five SAP patients and 85 gender- and age-matched healthy volunteers were enrolled. Presepsin concentrations were measured on admission from SAP patients and at study entry from healthy individuals...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28153679/evaluating-the-value-of-dynamic-procalcitonin-and-presepsin-measurements-for-patients-with-severe-sepsis
#2
Han Yu, Zhijiang Qi, Chenchen Hang, Yingying Fang, Rui Shao, Chunsheng Li
OBJECTIVE: This study comparatively evaluated the value of dynamic procalcitonin (PCT) and presepsin measurements in assessing therapeutic efficacy and prognosis for patients with severe sepsis. METHODS: Patients with severe sepsis (n=109) were enrolled and divided into survival and non-survival groups based on 90-day survival. PCT and presepsin levels were evaluated on days 1, 3, 5, 7, and 12. Sequential organ failure assessment (SOFA) was calculated. RESULTS: PCT from day 5 onward was weakly to moderately positively correlated with SOFA, whereas presepsin from day 3 onward was positively correlated...
January 22, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28133789/diagnostic-performance-of-procalcitonin-presepsin-and-c-reactive-protein-in-patients-with-hematological-malignancies
#3
Yasuhiro Ebihara, Kiyoko Kobayashi, Akaru Ishida, Tomoya Maeda, Naoki Takahashi, Yoshitada Taji, Norio Asou, Kenji Ikebuchi
INTRODUCTION: Infections represent a major complication of hematological malignancies. C-reactive protein (CRP) and procalcitonin (PCT) have been used as diagnostic biomarkers of infections, but do not produce definitive findings. Recently, a new biomarker, presepsin, has been used as a diagnostic tool for detecting infections in the fields of emergency and neonatal medicine. However, the usefulness of presepsin for identifying infections in patients with hematological malignancies, including those who develop febrile neutropenia, remains unclear...
January 30, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28099244/presepsin-scd14-st-is-a-novel-marker-for-risk-stratification-in-cardiac-surgery-patients
#4
Hagen Bomberg, Matthias Klingele, Stefan Wagenpfeil, Eberhard Spanuth, Thomas Volk, Daniel I Sessler, Hans-Joachim Schäfers, Heinrich Volker Groesdonk
BACKGROUND: Presepsin (soluble cluster-of-differentiation 14 subtype [sCD14-ST]) is a humoral risk stratification marker for systemic inflammatory response syndrome and sepsis. It remains unknown whether presepsin can be used to stratify risk in elective cardiac surgery. The authors therefore determined the usefulness of presepsin for risk stratification in patients having elective cardiac surgery. METHODS: Eight hundred fifty-six cardiac surgical patients were prospectively studied...
January 18, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28067676/severe-community-acquired-pneumonia-optimal-management
#5
Davide Leoni, Jordi Rello
PURPOSE OF REVIEW: Community-acquired pneumonia (CAP) is the leading cause of mortality among infectious diseases. Several efforts have been implemented to achieve better outcomes, but an important proportion of patients continue dying. This review focuses on the newest research on prognostic factors and diagnostics, opening new perspectives in the management of CAP. RECENT FINDINGS: CAP survival improved in recent years despite an increasing incidence of severe presentations...
January 6, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28056845/plasma-presepsin-level-is-an-early-diagnostic-marker-of-severe-febrile-neutropenia-in-hematologic-malignancy-patients
#6
Yusuke Koizumi, Kaoru Shimizu, Masayo Shigeta, Takafumi Okuno, Hitoshi Minamiguchi, Katsuyuki Kito, Keiko Hodohara, Yuka Yamagishi, Akira Andoh, Yoshihide Fujiyama, Hiroshige Mikamo
BACKGROUND: Febrile neutropenia (FN) is a common infectious complication in chemotherapy. The mortality of FN is higher in hematologic malignancy patients, and early diagnostic marker is needed. Presepsin is a prompt and specific marker for bacterial sepsis, but its efficacy in severe febrile neutropenia (FN) is not well confirmed. We tried to clarify whether it is a useful maker for early diagnosis of FN in patients during massive chemotherapy. METHODS: We measured plasma presepsin levels every 2-3 day in FN cases and evaluated its change during the course of massive chemotherapy...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28028489/biomarkers-for-diagnosis-of-sepsis-in-patients-with-systemic-inflammatory-response-syndrome-a-systematic-review-and-meta-analysis
#7
Yong Liu, Jun-Huan Hou, Qing Li, Kui-Jun Chen, Shu-Nan Wang, Jian-Min Wang
BACKGROUND: Sepsis is one of the most common diseases that seriously threaten human health. Although a large number of markers related to sepsis have been reported in the last two decades, the diagnostic accuracy of these biomarkers remains unclear due to the lack of similar baselines among studies. Therefore, we conducted a large systematic review and meta-analysis to evaluate the diagnostic value of biomarkers from studies that included non-infectious systemic inflammatory response syndrome patients as a control group...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27994922/diagnostic-and-prognostic-value-of-presepsin-for-subclinical-chorioamnionitis-in-pregnancies-between-23-28-week-with-preterm-premature-rupture-of-the-membranes
#8
Erbil Çakar, Şule Eren Çakar, Habibe Ayvacı Taşan, Deniz Karçaaltıncaba, Mehmet Baki Şentürk, Nermin Koç, Ramazan Uluhan
BACKGROUND: Presepsin is an inflammatory marker released from monocytes and macrophages as an acute reaction to microbial infection. We hypothesized that it may be useful in pregnancies with preterm premature rupture of the membranes (PPROM) for early diagnosis of subclinical chorioamnionitis. AIMS: To determine whether the plasma presepsin level has any diagnostic or prognostic value for subclinical chorioamnionitis in pregnancies complicated with PPROM. STUDY DESIGN: Prospective cohort study...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27972306/cost-effectiveness-analysis-of-presepsin-compared-with-c-reactive-protein-and-procalcitonin-in-detecting-severe-bacterial-infection-in-children-aged-29-days-to-36-months-old-with-fever-without-source
#9
J Amastha, L Berdejo, J Acosta-Reyes
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27925621/presepsin-for-the-detection-of-early-onset-sepsis-in-preterm-newborns
#10
Paolo Montaldo, Roberto Rosso, Alfredo Santantonio, Giovanni Chello, Paolo Giliberti
BACKGROUND: Early-onset sepsis (EOS) is responsible for an important fraction of neonatal morbidity and mortality all over the world. The aim of this study was to assess whether presepsin (P-SEP) can be a more accurate biomarker of EOS compared with pro-calcitonin (PCT) and C-reactive protein (CRP). STUDY DESIGN: Consecutive preterm neonates (<34 wk gestational age, admitted to Neonatal Intensive Care Unit by 6 h of age and undergoing sepsis evaluation) were recruited as part of a case-matched control study...
December 7, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27895404/presepsin-teardown-pitfalls-of-biomarkers-in-the-diagnosis-and-prognosis-of-bacterial-infection-in-cirrhosis
#11
Maria Papp, Tamas Tornai, Zsuzsanna Vitalis, Istvan Tornai, David Tornai, Tamas Dinya, Andrea Sumegi, Peter Antal-Szalmas
AIM: To evaluate the diagnostic and prognostic value of presepsin in cirrhosis-associated bacterial infections. METHODS: Two hundred and sixteen patients with cirrhosis were enrolled. At admission, the presence of bacterial infections and level of plasma presepsin, serum C-reactive protein (CRP) and procalcitonin (PCT) were evaluated. Patients were followed for three months to assess the possible association between presepsin level and short-term mortality. RESULTS: Present 34...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27889429/plasmatic-presepsin-scd14-st-concentrations-in-acute-pyelonephritis-in-adult-patients
#12
Yann-Erick Claessens, Eloise Trabattoni, Sophie Grabar, Laurent Quinquis, Guillaume Der Sahakian, Marine Anselmo, Jeannot Schmidt, Jean-Emmanuel de la Coussaye, Patrick Plaisance, Enrique Casalino, Gilles Potel, François Lecomte, Didier Borderie, Camille Chenevier-Gobeaux
INTRODUCTION: Presepsin (sCD14-ST) is an emerging biomarker for infection. We hypothesized that presepsin could specifically increase during acute pyelonephritis and correlate with severity. METHODS: We compared presepsin values in patients with acute pyelonephritis and controls, and we assessed its capacity to predict bacteraemia and admission in patients. RESULTS: In 312 patients with acute pyelonephritis (median age 33years), presepsin concentrations were higher than in controls (476 vs 200ng/L, p<0...
January 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27882005/can-blood-and-semen-presepsin-levels-in-males-predict-pregnancy-in-couples-undergoing-intra-cytoplasmic-sperm-injection
#13
Ali Ovayolu, Cansev Yilmaz Arslanbuğa, Ismet Gun, Belgin Devranoglu, Arman Ozdemir, Sule Eren Cakar
OBJECTIVE: To determine whether semen and plasma presepsin values measured in men with normozoospermia and oligoasthenospermia undergoing invitro-fertilization would be helpful in predicting ongoing pregnancy and live birth. METHODS: Group-I was defined as patients who had pregnancy after treatment and Group-II comprised those with no pregnancy. Semen and blood presepsin values were subsequently compared between the groups. Parametric comparisons were performed using Student's t-test, and non-parametric comparisons were conducted using the Mann-Whitney U test...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27859613/serial-measurement-of-presepsin-procalcitonin-and-c-reactive-protein-in-the-early-postoperative-period-and-the-response-to-antithymocyte-globulin-administration-after-heart-transplantation
#14
Janka Franeková, Peter Sečník, Petra Lavríková, Zdenek Kubíček, Lenka Hošková, Eva Kieslichová, Antonín Jabor
Differentiation between systemic inflammatory response syndrome and sepsis in surgical patients is of crucial significance. Procalcitonin (PCT) and C-reactive protein (CRP) are widely used biomarkers, but PCT becomes compromised after antithymocyte globulin (ATG) administration, and CRP exhibits limited specificity. Presepsin has been suggested as an alternative biomarker of sepsis. This study aimed to demonstrate the role of presepsin in patients after heart transplantation (HTx). Plasma presepsin, PCT, and CRP were measured in 107 patients serially for up to 10 days following HTx...
November 16, 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/27851060/1424-the-presepsin-level-on-icu-admission-is-a-marker-of-the-severity-of-icu-patients
#15
Kentaro Tokuda, Jun Maki, Noriyuki Kaku, Soichi Mizuguchi, Mitsuhiro Fukata, Tomohiko Akahoshi, Sumio Hoka, Yoshihiko Maehara
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27851010/1374-utility-of-presepsin-in-distinguishing-sepsis-from-systemic-inflammatory-response-syndrome
#16
Jana Hudcova, Debra Poutsiaka, Maryam Khan, Ahsan Waqas, Christopher Homsy, Stanley Nasraway
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27825177/diagnostic-value-of-presepsin-in-detection-of-early-onset-neonatal-sepsis
#17
Abdurrahman A Ozdemir, Yusuf Elgormus
Objective The aim of this study was to evaluate the efficacy of presepsin in both diagnosis and follow-up of early-onset neonatal sepsis (EOS) and also to compare its effectiveness with C-reactive protein (CRP) and procalcitonin (PCT). Methods A total of 29 term infants with EOS group and 40 term infants with control group were included in this study. Before initiating therapy, blood samples for whole blood count, CRP, PCT, presepsin, and culture were obtained from all neonates (T0). This procedure was repeated two times at 72 hours (T3) and day 7 (T7)...
November 8, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27823951/diagnostic-accuracy-of-presepsin-scd14-st-as-a-biomarker-of-infection-and-sepsis-in-the-emergency-department
#18
Luis García de Guadiana Romualdo, Patricia Esteban Torrella, Sergio Rebollo Acebes, María Dolores Albaladejo Otón, Roberto Jiménez Sánchez, Ana Hernando Holgado, Enrique Jiménez Santos, Alejandro Ortín Freire
BACKGROUND: Presepsin is a promising biomarker for the diagnosis and prognosis of sepsis. However, results reported about its value to diagnose sepsis in an emergency department (ED) are controversial, probably due to differences in the design of the studies. We have evaluated the diagnostic accuracy of presepsin for infection and sepsis, compared with procalcitonin (PCT) and C-reactive protein (CRP), in patients presenting to the emergency department (ED) with suspected infection. METHODS: 223 patients with suspected infection were enrolled for the study...
January 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27793578/diagnostic-value-of-sepsis-biomarkers-in-hematopoietic-stem-cell-transplant-recipients-in-a-condition-of-high-prevalence-of-gram-negative-pathogens
#19
Igor Stoma, Igor Karpov, Anatoly Uss, Oleg Rummo, Natalia Milanovich, Igor Iskrov
OBJECTIVE/BACKGROUND: A decision about the need for antimicrobial therapy in a patient with febrile neutropenia after hematopoietic stem cell transplantation (HSCT) is often complicated because of the low frequency of culture isolation and reduced clinical manifestation of infection. Usefulness and choice of sepsis biomarkers to distinguish bloodstream infection (BSI) from other causes of febrile episode is still argued in HSCT recipients in modern epidemiological situations characterized by the emergence of highly resistant gram-negative microorganisms...
October 20, 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27785932/elevated-soluble-cd14-subtype-presepsin-p-sep-levels-in-rheumatoid-arthritis-ra-patients-with-bacterial-infection
#20
Soichiro Tsuji, Ayako Kitatoube, Akie Kikuchi-Taura, Eri Oguro, Minoru Shigesaka, Yasutaka Okita, Takashi Shimizu, Takuro Nii, Satoru Teshigawara, Eriko Tanaka, Yoshinori Harada, Masato Matsushita, Jun Hashimoto, Shiro Ohshima, Gaku Takahashi, Shigeatsu Endo, Yukihiko Saeki
No abstract text is available yet for this article.
October 27, 2016: Modern Rheumatology
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