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Jiri Parenica, Jiri Jarkovsky, Jan Malaska, Alexandre Mebazaa, Jana Gottwaldova, Katerina Helanova, Jiri Litzman, Milan Dastych, Josef Tomandl, Jindrich Spinar, Ludmila Dostalova, Petr Lokaj, Marie Tomandlova, Monika Goldergova Pavkova, Pavel Sevcik, Matthieu Legrand
INTRODUCTION: Cardiogenic shock (CS) patients are at a high risk of developing infectious complications; however, their early detection is difficult, mainly due to a frequently occurring non-infectious inflammatory response, which accompanies an extensive myocardial infarction or a post-cardiac arrest syndrome. The goal of our prospective study was to describe infectious complications in CS and the immune/inflammatory response based on a serial measurement of several blood-based inflammatory biomarkers...
September 29, 2016: Shock
Satoru Nanno, Hideo Koh, Takako Katayama, Masamichi Hashiba, Ayumi Sato, Yosuke Makuuchi, Joji Nagasaki, Masatomo Kuno, Takuro Yoshimura, Hiroshi Okamura, Mitsutaka Nishimoto, Asao Hirose, Mika Nakamae, Takahiko Nakane, Masayuki Hino, Hirohisa Nakamae
Objective Recent studies suggest that presepsin (soluble CD14-subtype) is a useful diagnostic and prognostic marker for sepsis, with secretion by activated macrophages potentially dependent on phagocytosis of microorganisms. As "hemophagocytosis" is one of the major characteristics in patients with hemophagocytic syndrome (HPS), we hypothesized that presepsin may reflect the phagocytic activity and be a useful prognostic marker for HPS. Therefore, we aimed to assess the prognostic potential of presepsin in secondary HPS in adult patients with hematological malignancies...
2016: Internal Medicine
X Gao, B Y Zhu, W Z Wang, J Q He, D L Han, Y J Liu, H Meng, Q M Xiao, X T Liu, Y Y Han
OBJECTIVE: To investigate the value of serum presepsin concentration measurement in the clinical diagnosis and treatment of patients with pesticide poisoning patients. METHODS: A total of 160 patients with pesticide poisoning were enrolled as study subjects and divided into moderate organophosphate pesticide poisoning group (40 patients) , severe organophosphate pesticide poisoning group (40 patients) , abamectin pesticide poisoning group (40 patients) , and paraquat poisoning group (40 patients)...
May 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
Xiaofei Song, Yucheng Song, Yuan Yuan, Peng Zhang, Xuedong Zhang
BACKGROUND: Enterocutaneous fistula (ECF) poses a supreme challenge for the surgeons associated with abdominal sepsis, fluid electrolyte imbalance and undernutrition. Individual prognostic stratification is pivotal in the clinical management. Presepsin is a novel biomarker showing diagnostic and prognostic value in sepsis. We aimed to evaluate the prognostic value of presepsin in ECF. METHODS: Consecutive patients with ECF were enrolled if diagnosed as abdominal sepsis from June 2014 to June 2015...
September 2016: International Journal of Surgery
Gaku Takahashi, Shigehiro Shibata, Yasuo Fukui, Yoshikazu Okamura, Yoshihiro Inoue
Procalcitonin (PCT) and presepsin (PSEP) are sepsis markers, but their diagnostic accuracy may be compromised in acute kidney injury (AKI). We evaluated their diagnostic accuracy in patients with/without AKI. This retrospective study comprised 91 patients with at least one criterion of systematic inflammatory response syndrome. AKI markers plasma neutrophil gelatinase-associated lipocalin (NGAL), plasma cystatin C (CysC), and estimated glomerular filtration rate (eGFR) were measured upon hospital admission and on days 1, 3, 5, and 7...
October 2016: Diagnostic Microbiology and Infectious Disease
M Plesko, J Suvada, M Makohusova, I Waczulikova, D Behulova, A Vasilenkova, M Vargova, A Stecova, E Kaiserova, A Kolenova
Bacterial infection is the most common complication in paediatric oncological patients during cancer treatment. A suitable tool for early prediction of unfavourable course of infection is still needed. We performed a prospective longitudinal observational study to evaluate of the role of serum biomarkers (C-reactive protein, procalcitonin, interleukin-6, presepsin) in the early diagnosis of bacteraemia (gram-negative versus gram-positive) in patients with haematological malignancies. We observed 69 febrile episodes in 33 patients (17 male, 16 female; 1...
2016: Neoplasma
Kada Klouche, Jean Paul Cristol, Julie Devin, Vincent Gilles, Nils Kuster, Romaric Larcher, Laurent Amigues, Philippe Corne, Olivier Jonquet, Anne Marie Dupuy
BACKGROUND: The soluble CD14 subtype, Presepsin, appears to be an accurate sepsis diagnostic marker, but data from intensive care units (ICUs) are scarce. This study was conducted to evaluate the diagnostic and prognostic value of Presepsin in ICU patients with severe sepsis (SS), septic shock (SSh) and severe community-acquired pneumonia (sCAP). METHODS: Presepsin and procalcitonin (PCT) levels were determined for patients at admission to ICU. Four groups have been differentiated: (1) absence or (2) presence of systemic inflammatory response syndrome, (3) SS or (4) SSh; and 2 groups, among the patients admitted for acute respiratory failure: absence or presence of sCAP...
December 2016: Annals of Intensive Care
Fahmy T Ali, Mohamed A M Ali, Mostafa M Elnakeeb, Heba N M Bendary
Despite their undoubted helpfulness in diagnosing sepsis, increased blood C-reactive protein (CRP) and procalcitonin (PCT) levels have been described in many noninfectious conditions. Presepsin is a soluble fragment of the cluster of differentiation 14 involved in pathogen recognition by innate immunity. We aimed to investigate the diagnostic and prognostic performance of presepsin in comparison to PCT and CRP in patients presenting with systemic inflammatory response syndrome (SIRS) and suspected sepsis. Seventy-six subjects were enrolled in this study, including 51 patients with SIRS as well as 25 healthy subjects...
September 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Kohei Tsujimoto, Atsuko Hata, Masaaki Fujita, Saori Hatachi, Masato Yagita
AIM: To assess the diagnostic values of presepsin and procalcitonin in patients with rheumatoid arthritis (RA) by identifying those with bacterial infection METHOD: During June 2014-September 2015, 126 patients with RA and 25 healthy controls were enrolled. RA patients were divided into an infection group and a non-infection group. Infection was diagnosed by clinical symptoms, microbiological or radiographic methods, and good response to antibiotics. Concentrations of plasma presepsin, serum procalcitonin, C-reactive protein (CRP), and white blood cell counts (WBC) were measured and compared in each group...
June 13, 2016: International Journal of Rheumatic Diseases
O V Rotar
In 70 patients, suffering an acute necrotic pancreatitis (ANP), and 10 practically healthy persons a content of presepsin in a blood plasm, using immunochemiluminescent method and conducted bacteriological investigations, were analyzed. The infection occurrence is accompanied by plausible upgrading of a presepsin level in a blood plasm, depending on activity and severity of a septic process: in local infection--up to (677 ± 30) pg/ml, sepsis--up to (988 ± 47) pg/ml, severe sepsis--up to 2668 pg/ml; in an ANP without infection it have constituted (332 ± 38) pg/mI at average, in practically healthy persons--(184 ± 16) pg/mI...
January 2016: Klinichna Khirurhiia
Jianbo Lin, Huidong Sun, Jiangong Li, Yanhong Zheng, Cunhua Shao, Yang Hong Zhang, Hong Chang
BACKGROUND: Presepsin is a new emerging inflammatory biomarker. The primary purpose of this study was to elucidate the predictive usability of presepsin for severity assessment in patients with acute cholangitis (AC). METHODS: A total of 119 treatment-naive patients with AC (64 males, 55 females) were enrolled in this study. Patients were classified with Grade I (mild), Grade II (moderate), or Grade III (severe) AC based on severity assessment guidelines. Presepsin concentrations were measured on admission...
2016: Clinical Laboratory
Shouichi Sato, Kiyoshi Ichihara
OBJECTIVE: Clinical utility of a new marker for sepsis, presepsin, was evaluated by use of a case-control study design. METHOD: Enrolled in the study were seventy-one consecutive cases for whom blood culture was ordered in suspicion of sepsis. After the culture, 36 subjects were diagnosed as having a state of sepsis (S group) and 35 were denied of sepsis (NS group). The serum level of presepsin was measured together with basic chemistry tests and complete blood counts at the time of diagnosis...
January 2016: Rinsho Byori. the Japanese Journal of Clinical Pathology
Hideo Koh, Mizuki Aimoto, Takako Katayama, Masamichi Hashiba, Ayumi Sato, Masatomo Kuno, Yosuke Makuuchi, Teruto Takakuwa, Hiroshi Okamura, Asao Hirose, Mika Nakamae, Masayuki Hino, Hirohisa Nakamae
BACKGROUND: Whether presepsin (soluble CD14-subtype) is better than other markers including procalcitonin (PCT), has not been adequately investigated in febrile neutropenia (FN). METHODS: We prospectively examined the utility of presepsin in FN in Cohort 1 (C1) and 2 (C2), between November 2010 and February 2012, and between November 2013 and January 2014, respectively. The purpose of this study was to investigate 1) the relative value of serum presepsin over serum PCT in C1, and 2) the relative value of plasma presepsin as compared with serum PCT, C-reactive protein, interleukin-6 and interleukin-8 with frequent, repeated sampling in C2...
July 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Waka Takahashi, Taka-Aki Nakada, Megumi Yazaki, Shigeto Oda
INTRODUCTION: There are significant unmet requirements for rapid differential diagnosis of infection in patients admitted to intensive care units. Serum levels of interleukin-6 (IL-6), procalcitonin (PCT), presepsin, and C-reactive protein (CRP) are measured in clinical practice; however, their clinical utility in patients with organ dysfunction has not been tested adequately. Thus, we investigated the diagnostic and prognostic value of IL-6, PCT, presepsin, and CRP in critically ill patients who had organ dysfunction with suspicion of infection...
September 2016: Shock
Christian Leli, Marta Ferranti, Umberto Marrano, Zainab Salim Al Dhahab, Silvia Bozza, Elio Cenci, Antonella Mencacci
Early diagnosis and prompt targeted therapy are essential for septic patients' outcome. Procalcitonin (PCT) has been shown to predict bacteraemia and bacterial DNAaemia. Presepsin, the circulating soluble form of CD14 subtype, increases in response to bacterial infections, and is considered a new, emerging, early marker for sepsis. We evaluated the diagnostic accuracy of presepsin in predicting bacteraemia and bacterial DNAaemia in 92 patients with suspected sepsis, and we compared it with that of PCT and C-reactive protein (CRP)...
August 2016: Journal of Medical Microbiology
Dario Galeano, Luca Zanoli, Pasquale Fatuzzo, Antonio Granata
Since many years, researchers have focused their studies to find out early sepsis biomarkers for the purpose of gaining time in the application of early goal-directed therapy protocol. Procalcitonin (PCT) is a reliable biomarker for sepsis, although it has a low specificity and prognostic value. Other recently proposed sepsis biomarkers such as interleukins, C-reactive protein (CRP), myeloid cells expressing triggering receptor-1 (TREM-1) and soluble urokinase-type plasminogen activator receptor (suPAR) still have a controversial and uncertain clinical value...
March 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Özlem Demirpençe, Halef Okan Doğan, Serpil Erşan, Mehtap Şahin, Hasan Şahin, Mehmet Bakır
The presepsin level (a soluble CD14 subtype) is thought to increase in cases of bacterial infection. It has been stated that CD 14 also plays a role in the pathogenesis of various viral diseases. Crimean-Congo Hemorrhagic Fever (CCHF) is an arboviral zoonotic infection. Our study focuses on the presepsin level as a biomarker for CCHF. Serum presepsin levels in CCHF group (n=59) and control (n=28) have been compared. Patients with CCHF have been classified as mild, moderate and severe groups (group 1, 2 and 3 respectively) in terms of the Severity Grading Score (SGS)...
March 18, 2016: Japanese Journal of Infectious Diseases
Haitham Al-Ashry, Ahmed Abuzaid, Mohammad Asim, Ayman El-Menyar
INTRODUCTION: Septic shock is represented by severe hemodynamic changes which are manifested with failure of organ systems and high mortality. Early diagnosis together with timely and appropriate treatment is important to attain better outcome. OBJECTIVES: We reviewed the diagnostic approach of septic shock in relation to the microcirculatory abnormalities, novel biomarkers, monitoring, interventions, and therapy. METHODS: A narrative literature review was carried out using PubMed, MEDLINE and Google scholar search engines...
2016: Current Vascular Pharmacology
Zhongjun Zheng, Libing Jiang, Ligang Ye, Yuzhi Gao, Luping Tang, Mao Zhang
BACKGROUND: Sepsis is a common condition that has a high mortality and morbidity that need prompt diagnosis and treatment. Biomarkers like Soluble CD14 subtype (sCD14-ST, presepsin) may be useful in identifying patients with sepsis and its diagnostic superiority has been confirmed by several preliminary studies. The aim of this study was systematically and quantitatively to evaluate the value of presepsin for the diagnosis of sepsis through the method of meta-analysis. METHODS: Four major databases, including MEDLINE, EMBASE, ISI Web of Knowledge, and the Cochrane Library were systematically searched from inception to March 2015...
December 2015: Annals of Intensive Care
Jing Zhang, Zhi-De Hu, Jia Song, Jiang Shao
Several individual studies have reported the diagnostic accuracy of presepsin (sCD14-ST) for sepsis, but the results are inconsistent.The present systematic review and meta-analysis pooled data to better ascertain the value of circulatory presepsin as a biomarker for sepsis.Studies published in English before November 7, 2014 and assessing the diagnostic accuracy of presepsin for sepsis were retrieved from medical databases.The quality of eligible studies was assessed using a revised Quality Assessment for Studies of Diagnostic Accuracy (QUADAS-2)...
November 2015: Medicine (Baltimore)
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