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Presepsin

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https://www.readbyqxmd.com/read/29752615/effects-of-simvastatin-on-the-function-of-splenic-cd4-and-cd8-t-cells-in-sepsis-mice
#1
Bingbing Kong, Xiaofeng Wang, Wenping Yang, Xin Zhao, Rong Zhang, Yu Wang
Simvastatin may be beneficial for treating sepsis due to its immune-regulating properties, although the mechanisms remain elusive. Herein, we hypothesized simvastatin may attenuate T cell dysfunction induced by sepsis. To test this hypothesis, we used a model based on cecal ligation and puncture (CLP) to induce sepsis in mice. Male C57BL/6 mice were pre-treated with simvastatin (0.2 μg/g of body weight) before CLP. The expression of B and T lymphocyte attenuator (BTLA) on splenic CD4+ T cells and T cell apoptosis, CD4+ and CD8+ T cells were quantified by flow cytometry...
May 11, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29742943/comparison-between-presepsin-and-procalcitonin-in-early-diagnosis-of-neonatal-sepsis
#2
Agustin Iskandar, Maimun Z Arthamin, Kristin Indriana, Muhammad Anshory, Mina Hur, Salvatore Di Somma
BACKGROUND: Neonatal sepsis remains worldwide one of the leading causes of morbidity and mortality in both term and preterm infants. Lower mortality rates are related to timely diagnostic evaluation and prompt initiation of empiric antibiotic therapy. Blood culture, as gold standard examination for sepsis, has several limitations for early diagnosis, so that sepsis biomarkers could play an important role in this regard. This study was aimed to compare the value of the two biomarkers presepsin and procalcitonin in early diagnosis of neonatal sepsis...
May 9, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29742588/derivation-and-validation-of-a-biomarker-based-clinical-algorithm-to-rule-out-sepsis-from-noninfectious-systemic-inflammatory-response-syndrome-at-emergency-department-admission-a-multicenter-prospective-study
#3
Filippo Mearelli, Nicola Fiotti, Carlo Giansante, Chiara Casarsa, Daniele Orso, Marco De Helmersen, Nicola Altamura, Maurizio Ruscio, Luigi Mario Castello, Efrem Colonetti, Rossella Marino, Giulia Barbati, Andrea Bregnocchi, Claudio Ronco, Enrico Lupia, Giuseppe Montrucchio, Maria Lorenza Muiesan, Salvatore Di Somma, Gian Carlo Avanzi, Gianni Biolo
OBJECTIVES: To derive and validate a predictive algorithm integrating a nomogram-based prediction of the pretest probability of infection with a panel of serum biomarkers, which could robustly differentiate sepsis/septic shock from noninfectious systemic inflammatory response syndrome. DESIGN: Multicenter prospective study. SETTING: At emergency department admission in five University hospitals. PATIENTS: Nine-hundred forty-seven adults in inception cohort and 185 adults in validation cohort...
May 7, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29683405/longitudinal-evaluation-of-plasma-concentrations-of-presepsin-in-patients-after-severe-trauma-a-prospective-observational-study
#4
Christian Koch, Sophie Ruhrmann, Michael Pöhlmann, Emmanuel Schneck, Borros Arneth, Thomas Zajonz, Michael Sander, Markus A Weigand, Florian Uhle
BACKGROUND: The high mortality rate of patients suffering from severe trauma is based not only on the mechanism of injury, but also on the higher risk for development of subsequent infections. Therefore, the early recognition of infection after severe trauma is of particular importance for patient outcome. However, early diagnosis is often masked by the consequences of the sterile, damage-triggered immune response. Our study sought to analyze the course of soluble CD14-subtype (sCD14-ST, presepsin) compared with clinically established inflammatory and infectious biomarkers in a cohort of patients with severe trauma...
April 23, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29616457/presepsin-as-a-diagnostic-marker-of-bacterial-infections-in-febrile-neutropenic-pediatric-patients-with-hematological-malignancies
#5
Ahmad Baraka, Marwa Zakaria
Febrile neutropenia (FN) is often observed in hematological malignancies (HEM). Presepsin is also known as soluble CD14 subtype; it is a glycoprotein fragment derived from monocytes and macrophages. We aimed to evaluate the significance of presepsin and other biomarkers for diagnosis of bacteremia in children with HEM. Sixty pediatric patients with different HEM (acute lymphoblastic leukemia 36, acute myeloid leukemia 12, non-Hodgkin lymphoma 10, and Hodgkin disease 2). Thirty age and sex-matched healthy children serving as control were enrolled in this study...
April 3, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29593897/serum-presepsin-levels-are-not-elevated-in-patients-with-controlled-hypertension
#6
Ismail Biyik, Fatma Nihan Turhan Caglar, Nilgun Isiksacan, Nursel Kocamaz, Pınar Kasapoglu, Asuman Gedikbasi, Faruk Akturk
Introduction: Hypertension (HT) is a common serious condition associated with cardiovascular morbidity and mortality. The pathogenesis of HT is multifactorial and has been widely investigated. Besides the vascular, hormonal, and neurological factors, inflammation plays a crucial role in HT. Many inflammatory markers such as C-reactive protein, cytokines, and adhesion molecules have been studied in HT, which supported the role of inflammation in the pathogenesis of HT. Presepsin (PSP) is a novel biomarker of inflammation...
2018: International Journal of Hypertension
https://www.readbyqxmd.com/read/29577181/a-comparative-evaluation-of-presepsin-with-procalcitonin-and-crp-in-diagnosing-neonatal-sepsis
#7
Neeraj Kumar, Rajeshwar Dayal, Pratibha Singh, Sunit Pathak, Vishal Pooniya, Ankur Goyal, Raj Kamal, K K Mohanty
The objectives of this study were to study the clinical and biochemical profile of neonates with sepsis and to evaluate the diagnostic role of presepsin and its comparison with C-reactive protein (CRP) and Procalcitonin (PCT). This study was conducted from March 2015 through October 2016 in Neonatal intensive care unit (NICU) at S N Medical College, Agra. Neonates with ≥1 clinical features of sepsis and/or two risk factors were included. A total of 41 cases and 41 controls were taken. Blood sample was taken for all investigations...
March 26, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29540108/neutrophil-cd64-expression-procalcitonin-and-presepsin-are-useful-to-differentiate-infections-from-flares-in-sle-patients-with-sirs
#8
A Echeverri, J Naranjo-Escobar, I Posso-Osorio, D Aguirre-Valencia, D Zambrano, G L Castaño, J D Martínez, C A Cañas, G J Tobón
Background/Objective Differentiating systemic lupus erythematosus (SLE) activity from infections in febrile patients is difficult because of similar initial clinical presentation. The aim of this study is to evaluate the usefulness of a number of biomarkers for differentiating infections from activity in SLE patients admitted with systemic inflammatory response (SIRS). Methods Patients with SLE and SIRS admitted to the emergency room were included in this study. Measurements of different markers including procalcitonin, neutrophil CD64 expression and presepsin, were performed...
June 2018: Lupus
https://www.readbyqxmd.com/read/29497398/cerebrospinal-fluid-presepsin-as-a-marker-of-nosocomial-infections-of-the-central-nervous-system-a-prospective-observational-study
#9
Sergey A Abudeev, Kirill V Kiselev, Nikolay M Kruglyakov, Ksenia A Belousova, Inna N Lobanova, Oleg V Parinov, Yuriy D Udalov, Maxim A Zabelin, Alexandr S Samoilov, Evaldas Cesnulis, Tim Killeen, Konstantin A Popugaev
Background: Nosocomial CNS infection (NI-CNS) is a common and serious complication in neurocritical care patients. Timely, accurate diagnosis of NI-CNS is crucial, yet current infection markers lack specificity and/or sensitivity. Presepsin (PSP) is a novel biomarker of macrophage activation. Its utility in NI-CNS has not been explored. We first determined the normal range of cerebrospinal fluid (CSF) PSP in a control group without brain injury before collecting data on CSF PSP levels in neurocritical care patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29495098/presepsin-as-predictor-of-eons-in-umbilical-cord-blood-of-premature-with-prom
#10
Wael Seliem, Amira M Sultan
BACKGROUND: The aim of our study is to use presepsin level in umbilical cord blood as a predictor of EONS in preterm labor with premature rupture of membranes allowing rational use of antibiotics. METHODS: All preterm infants between 24+0 and 36+6 weeks of gestation born to pregnant women with a PROM were enrolled in our study. Blood samples were obtained from clamped umbilical cords after delivery of the neonates and prior to the delivery of the placenta for CRP and presepsin detection...
March 1, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29489459/presepsin-and-inflammatory-markers-correlate-with-occurrence-and-severity-of-nonocclusive-mesenteric-ischemia-after-cardiovascular-surgery
#11
Jonas Stroeder, Hagen Bomberg, Stefan Wagenpfeil, Arno Buecker, Hans-Joachim Schaefers, Marcus Katoh, Heinrich Volker Groesdonk, Peter Minko
OBJECTIVES: To prospectively evaluate the relationship of established inflammatory markers and presepsin on nonocclusive mesenteric ischemia and to correlate presepsin levels to the occurrence and severity of nonocclusive mesenteric ischemia. DESIGN: Patients were prospectively enrolled and blood samples taken, followed by a retrospective evaluation of laboratory values and angiographic findings. The study was ethics committee approved. SETTINGS: Patients with clinical suspicion of nonocclusive mesenteric ischemia underwent catheter angiography of the superior mesenteric artery...
February 27, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29476345/the-diagnostic-accuracy-of-presepsin-in-neonatal-sepsis-a-meta-analysis
#12
REVIEW
Ioannis Bellos, Georgia Fitrou, Vasilios Pergialiotis, Nikolaos Thomakos, Despina N Perrea, Georgios Daskalakis
There is growing evidence that presepsin is a promising biomarker in the diagnosis of sepsis in adults. The objective of our study is to investigate current evidence related to the diagnostic accuracy of presepsin in neonatal sepsis. To accomplish this, we searched the Medline (1966-2017), Scopus (2004-2017), Clinicaltrials.gov (2008-2017), EMBASE (1980-2017), Cochrane Central Register of Controlled Trials CENTRAL (1999-2017), and Google Scholar (2004-2017) databases. Eleven studies were included in the present meta-analysis, with a total number of 783 neonates...
May 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29465204/-diagnostic-value-of-the-homeostasis-parameters-in-sepsis-detecting-in-patients-with-infectious-inflammatory-complications-during-the-postoperative-period
#13
O V Dymova, A A Eremenko, V V Nikoda, O N Vasilieva, A V Bondarenko, N S Bogomolova, Yu E Mikhailov
Purpose of the study was to define the diagnostic value of clinical and laboratory criteria of sepsis during the postop- erative period Methods. The results of 269 blood tests (biochemical, coagulation, hematology and microbiology) which were per- formed in 115 patients in the early postoperative period (starting from the first postoperative day) and in the late post- operative periods were analyzed. RESULTS: Presepsin and procalcitonin have a similar diagnostic sensitivity in detection of sepsis - 89% (Psp>328...
September 2017: Anesteziologiia i Reanimatologiia
https://www.readbyqxmd.com/read/29364941/prognostic-value-of-presepsin-in-adult-patients-with-sepsis-systematic-review-and-meta-analysis
#14
Hyun Suk Yang, Mina Hur, Ahram Yi, Hanah Kim, Seungho Lee, Soo-Nyung Kim
OBJECTIVE: Presepsin is a novel biomarker to diagnose sepsis but its prognostic value has not been comprehensively reviewed. We conducted this meta-analysis to evaluate the mortality prediction value of presepsin in sepsis. METHODS: We searched comprehensive electronic databases from PubMed, EMBASE, and Cochrane Library through September 2017 using the key words of ('presepsin' or 'sCD14-ST' or 'soluble CD14 subtype') and ('sepsis' or 'septic shock') and ('prognosis' or 'prognostic value' or 'prognostic biomarker' or 'mortality')...
2018: PloS One
https://www.readbyqxmd.com/read/29303798/decrease-in-histidine-rich-glycoprotein-as-a-novel-biomarker-to-predict-sepsis-among-systemic-inflammatory-response-syndrome
#15
Kosuke Kuroda, Hidenori Wake, Shuji Mori, Shiro Hinotsu, Masahiro Nishibori, Hiroshi Morimatsu
OBJECTIVES: Many biomarkers for sepsis are used in clinical practice; however, few have become the standard. We measured plasma histidine-rich glycoprotein levels in patients with systemic inflammatory response syndrome. We compared histidine-rich glycoprotein, procalcitonin, and presepsin levels to assess their significance as biomarkers. DESIGN: Single-center, prospective, observational cohort study. SETTING: ICU at an university-affiliated hospital...
April 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29289622/presepsin-as-a-novel-diagnostic-biomarker-for-differentiating-active-pulmonary-tuberculosis-from-bacterial-community-acquired-pneumonia
#16
Zhi-Jiang Qi, Han Yu, Jing Zhang, Chun-Sheng Li
BACKGROUND: The expression of presepsin in active pulmonary tuberculosis (APTB) is unknown. We observed the expression of presepsin in APTB, and to evaluate the value for discriminating between APTB and bacterial community acquired pneumonia (BCAP). METHODS: Consecutive APTB patients who were accurately diagnosed by sputum culture and BCAP patients were enrolled from August 2013 to July 2015. Clinical data were collected, and plasma presepsin concentrations were tested...
March 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29276032/the-utility-of-presepsin-in-diagnosis-and-risk-stratification-for-the-emergency-patients-with-sepsis
#17
Bin Lu, Yan Zhang, Chen Li, Chenyan Liu, Ying Yao, Minghuan Su, Songtao Shou
OBJECTIVES: To evaluate the value of presepsin in diagnosis and risk stratification of septic patients in emergency department, and investigate the utility in differentiation of gram-positive and gram-negative bacterial infection. METHODS: We enrolled 72 patients with sepsis and 23 nonbacterial patients with systemic inflammatory response syndrome (SIRS) who were admitted to the emergency department of Tianjin Medical University General Hospital. Meanwhile, 20 healthy volunteers were included...
December 20, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29260754/-evolution-of-laboratory-markers-for-systemic-bacterial-infections
#18
REVIEW
N L Ryabkova, N N Vezikova
The paper reviews the data available in the literature on existing laboratory markers for systemic bacterial infection, among which C-reactive protein, proinflammatory cytokines, procalcitonin test, and presepsin receive primary emphasis.
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29251667/procalcitonin-and-presepsin-as-prognostic-markers-after-out-of-hospital-cardiac-arrest
#19
Pirkka T Pekkarinen, Giuseppe Ristagno, Erika Wilkman, Serge Masson, Roberto Latini, Johanna Laurikkala, Stepani Bendel, Tero Ala-Kokko, Tero Varpula, Jukka Vaahersalo, Sari Karlsson, Marjaana Tiainen, Monica M Mion, Mario Plebani, Ville Pettilä, Markus B Skrifvars
BACKGROUND: Patients resuscitated from cardiac arrest commonly develop an inflammatory response called post-cardiac arrest syndrome that clinically resembles septic shock.Procalcitonin and presepsin are associated with inflammation. We hypothesized that these biomarkers reflect the severity of post-cardiac arrest syndrome and predict short-term haemodynamical instability and long-term neurological outcome after cardiac arrest. METHODS: As a subcohort analysis of a prospective, observational, multi-centre study "FINNRESUSCI", we obtained plasma from 277 intensive care unit (ICU) patients treated following out-of-hospital cardiac arrest (OHCA)...
December 14, 2017: Shock
https://www.readbyqxmd.com/read/29251000/presepsin-a-potential-biomarker-of-pji-a-comparative-analysis-with-known-and-new-infection-biomarkers
#20
Monica Gioia Marazzi, Filippo Randelli, Marco Brioschi, Lorenzo Drago, Carlo Luca Romanò, Giuseppe Banfi, Luca Massaccesi, Calogero Crapanzano, Franca Morelli, Massimiliano Marco Corsi Romanelli, Emanuela Galliera
There is still no "gold standard" for the diagnosis and prognosis of post-operative periprosthetic joint infection (PJI). Among serum biomarkers, an emerging molecule is presepsin, the soluble fraction of CD14, recently described in other settings as a powerful diagnostic tool to detect sepsis at different degrees of severity. The aim of this study was to investigate the diagnostic and prognostic value of presepsin in PJI. A total of 30 patients with PJI and 30 patients without PJI were enrolled. Presepsin, C-reactive protein (CRP), serum interleukin (IL)-6, triggering receptor expressed on myeloid cells 1 (TREM-1), CCL2, matrix metalloproteinase 9 (MMP-9), CD163, osteopontin (OPN), and toll-like receptor 2 (TLR2) were measured at different times after surgery...
January 2018: International Journal of Immunopathology and Pharmacology
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