Leila Chaouch, Miniar Kalai, Manel Ben Jbara, Arij Ben Chaabene, Imen Darragi, Dorra Chaouachi, Fethi Mallouli, Raouf Hafsia, Abderraouf Ghanem, Salem Abbes
AIMS: The skeletal manifestations of sickle cell disease are the result of changes in bone and bone marrow caused by chronic tissue hypoxia that is exacerbated by episodic occlusion of the microcirculation by the abnormal sickle cells. Furthermore, the occurrence of osteonecrosis is under the control of some modifier gene. BMP6 (Bone morphogenetic protein) has been reported as associated with osteonecrosis in sickle cell anemia (SCA). Herein, we intend to study the impact of rs267196, rs267201, rs408505 and rs449853 of BMP6 gene in the occurrence of osteonecrosis among sickle cell patients in Tunisia...
March 2015: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia