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https://www.readbyqxmd.com/read/29912589/lactobacillus-plantarum-prevents-and-mitigates-alcohol-induced-disruption-of-colonic-epithelial-tight-junctions-endotoxemia-and-liver-damage-by-an-egf-receptor-dependent-mechanism
#1
Pradeep K Shukla, Avtar S Meena, Bhargavi Manda, Maria Gomes-Solecki, Paula Dietrich, Ioannis Dragatsis, RadhaKrishna Rao
Pathogenesis of alcohol-related diseases such as alcoholic hepatitis involves gut barrier dysfunction, endotoxemia, and toxin-mediated cellular injury. Here we show that Lactobacillus plantarum not only blocks but also mitigates ethanol (EtOH)-induced gut and liver damage in mice. L. plantarum blocks EtOH-induced protein thiol oxidation, and down-regulation of antioxidant gene expression in colon L. plantarum also blocks EtOH-induced expression of TNF-α, IL-1β, IL-6, monocyte chemotactic protein 1 ( MCP1), C-X-C motif chemokine ligand ( CXCL)1, and CXCL2 genes in colon...
June 18, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29909039/integrin-%C3%AE-6-and-egfr-signaling-converge-at-mechanosensitive-calpain-2
#2
A D Schwartz, C L Hall, L E Barney, C C Babbitt, S R Peyton
Cells sense and respond to mechanical cues from the extracellular matrix (ECM) via integrins. ECM stiffness is known to enhance integrin clustering and response to epidermal growth factor (EGF), but we lack information on when or if these mechanosensitive growth factor receptors and integrins converge intracellularly. Towards closing this knowledge gap, we combined a biomaterial platform with transcriptomics, molecular biology, and functional assays to link integrin-mediated mechanosensing and epidermal growth factor receptor (EGFR) signaling...
June 2, 2018: Biomaterials
https://www.readbyqxmd.com/read/29908295/hyperglycaemic-impairment-of-par2-mediated-vasodilation-prevention-by-inhibition-of-aortic-endothelial-sodium-glucose-co-transporter-2-and-minimizing-oxidative-stress
#3
Mahmoud El-Daly, Vivek Krishna Pulakazhi Venu, Mahmoud Saifeddine, Koichiro Mihara, Sean Kang, Paul W M Fedak, Laurie A Alston, Simon A Hirota, Hong Ding, Chris R Triggle, Morley D Hollenberg
Hyperglycaemia is a major contributor to diabetic cardiovascular disease with hyperglycaemia-induced endothelial dysfunction recognized as the initiating cause. Coagulation pathway-regulated proteinase-activated receptors (PARs) that can regulate vascular tone in vivo cause eNOS-mediated endothelium-dependent vasodilation; but, the impact of hyperglycaemia on this vasodilatory action of PAR stimulation and the signalling pathways involved are unknown. We hypothesized that vascular sodium-glucose co-transporter 2 activity and hyperglycaemia-induced oxidative stress involving Src-kinase, EGF receptor-kinase, Rho-kinase and protein-kinase-C biochemical signalling pathways would compromise PAR2-mediated endothelium-dependent vasodilation...
June 13, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29904688/data-on-mass-spectrometry-based-proteomics-for-studying-the-involvement-of-cyld-in-the-ubiquitination-events-downstream-of-egfr-activation
#4
Virginia Sanchez-Quiles, Nerea Osinalde, Vyacheslav Akimov, Irina Kratchmarova, Blagoy Blagoev
The present data article corresponds to the proteomic data of the involvement of Cylindromatosis protein (CYLD) in the ubiquitination signaling initiated by EGF stimulation. CYLD tumor suppressor protein has Lys63-chain deubiquitinase activity that has been proved essential for the negative regulation of crucial signaling mechanisms, namely the NFkB pathway. Previous results have suggested the involvement of CYLD in the EGF-dependent signal transduction as well, showing its engagement within the tyrosine-phosphorylated complexes formed following the addition of the growth factor...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29904416/experimental-study-of-epidermal-growth-factor-and-acidic-fibroblast-growth-factor-in-the-treatment-of-diabetic-foot-wounds
#5
Jiasheng Xu, Dinghong Min, Guanghua Guo, Xincheng Liao, Zhonghua Fu
The aim of the present study was to investigate the effect of epidermal growth factor (EGF) and acidic fibroblast growth factor (aFGF) on the healing of diabetic foot wounds. A total of 199 patients with diabetic foot ulcers were recruited and randomly divided into four groups: A recombinant human EGF group (n=50), an aFGF group (n=50), a combined EGF and aFGF group (n=50) and a normal saline control group (n=49). Patients in all groups received a daily dressing change and growth factor reagents were applied topically when dressing...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904166/pharmacological-activation-of-epidermal-growth-factor-receptor-signaling-inhibits-colitis-associated-cancer-in-mice
#6
Philip E Dubé, Cambrian Y Liu, Nandini Girish, M Kay Washington, D Brent Polk
Current treatments for inflammatory bowel disease (IBD) target the overactive immune response of the intestinal mucosa. However, epidermal growth factor (EGF), an activating ligand of the EGF receptor (EGFR), has been shown to induce disease remission through direct targeting of intestinal mucosal healing. Despite promising preclinical and clinical results, this EGFR-activating therapy has not progressed, in part due to the potential for carcinogenesis associated with long-term use and the increased risk of colitis-associated cancer (CAC) in IBD...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29903662/synthesis-and-antitumor-activity-of-novel-6-7-8-trimethoxy-n-aryl-substituted-4-aminoquinazoline-derivatives
#7
Fang Liu, Ziyou Huai, Guotai Xia, Liuping Song, Sha Li, Yulan Xu, Kangjun Hong, Mingyue Yao, Gang Liu, Yinjiu Huang
A series of 6,7,8-trimethoxy N-aryl-substituted-4-aminoquinazoline derivatives were synthesized as epidermal growth factor receptor (EGFR) inhibitors, and their antitumor activities were assessed in the gastric cancer cell line SGC7901 using MTT assay. All compounds of Tg1-14 were found to inhibit SGC7901 cell proliferation, and compound Tg11 (IC50  = 0.434 μM) was found to be slightly more effective against SGC7901 cells than epirubicin (IC50  = 5.16 μM). This suggests that compound Tg11 can be used as a new substitution structure to develop more efficacious antitumor agents...
May 18, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29902818/-substances-in-the-bovine-colostrum-a-survey
#8
Sebastian Ganz, Michael Bülte, Zdzislaw Gajewski, Axel Wehrend
The best studied substances in bovine colostrum are the immunoglobulins. They are absorbed in the small intestine of the neonate by pinocytosis. The Fc-receptor is not highly involved in this process in calves compared to other species. However, this receptor plays a crucial role in the transport of immunoglobulins from the circulation of the dam to the udder and, therefore, into the colostrum. During colostrogenesis, which starts up to 8 weeks prior to parturition, up to 500 g of immunoglobulins are transferred daily by this process...
June 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/29902719/surmounting-the-resistance-against-egfr-inhibitors-through-the-development-of-thieno-2-3-d-pyrimidine-based-dual-egfr-her2-inhibitors
#9
Sandra N Milik, Amal Kamal Abdel-Aziz, Deena S Lasheen, Rabah A T Serya, Saverio Minucci, Khaled A M Abouzid
In light of the emergence of resistance against the currently available EGFR inhibitors, our study focuses on tackling this problem through the development of dual EGFR/HER2 inhibitors with improved enzymatic affinities. Guided by the binding mode of the marketed dual EGFR/HER2 inhibitor, Lapatinib, we proposed the design of dual EGFR/HER2 inhibitors based on the 6-phenylthieno[2,3-d]pyrimidine as a core scaffold and hinge binder. After two cycles of screening aiming to identify the optimum aniline headgroup and solubilizing group, we eventually identified 27b as a dual EGFR/HER2 inhibitor with IC50 values of 91...
June 6, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29902456/neuregulin-4-is-an-angiogenic-factor-that-is-critically-involved-in-the-maintenance-of-adipose-tissue-vasculature
#10
Dhite Bayu Nugroho, Koji Ikeda, Agian Jeffilano Barinda, Donytra Arby Wardhana, Keiko Yagi, Keishi Miyata, Yuichi Oike, Ken-Ichi Hirata, Noriaki Emoto
Adipose tissue (AT) contains well-developed vascular networks. Pathological AT expansion often accompany the reduction in AT blood vessels, which further exacerbates adipocyte dysfunction due to hypoxia; however, it remains unclear whether AT vascular rarefaction is simply secondary to adipocyte hypertrophy, or if there is an actively regulated pathway that mediates impaired AT angiogenesis in obesity. We searched for growth factors whose expression in AT is down-regulated in obesity; accordingly, we identified neuregulin-4 (Nrg4), a member of the EGF family of proteins...
June 11, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29902227/modeling-human-early-otic-sensory-cell-development-with-induced-pluripotent-stem-cells
#11
Hanae Lahlou, Alejandra Lopez-Juarez, Arnaud Fontbonne, Emmanuel Nivet, Azel Zine
The inner ear represents a promising system to develop cell-based therapies from human induced pluripotent stem cells (hiPSCs). In the developing ear, Notch signaling plays multiple roles in otic region specification and for cell fate determination. Optimizing hiPSC induction for the generation of appropriate numbers of otic progenitors and derivatives, such as hair cells, may provide an unlimited supply of cells for research and cell-based therapy. In this study, we used monolayer cultures, otic-inducing agents, Notch modulation, and marker expression to track early and otic sensory lineages during hiPSC differentiation...
2018: PloS One
https://www.readbyqxmd.com/read/29901281/silk-nanofibrous-electrospun-scaffold-enhances-differentiation-of-embryonic-stem-like-cells-derived-from-testis-in-to-mature-neuron
#12
M Nazm Bojnordi, S Ebrahimi-Barough, E Vojoudi, H H Ghasemi
The scaffolds accompanied with stem cells have great potential for applications in neural tissue engineering. Fabrication of Nano fibrous scaffold similar to extracellular matrix is one of the applicable methods in neural tissue regeneration. The aim of this study was the fabrication of a silk Nano fibrous scaffold as a microenvironment for neural guiding differentiation of Embryonic stem like cells (ES Like cells) derived from testis toward neuron-like cells. ES Like derived from culturing of testicular cells in vitro, were seeded on Silk scaffolds and induced to neuronal phenotype using 4-/4± RA technique following culturing the cells in the neurobasal medium supplemented with 20 ng/ml bFGF,10 ng/ml EGF, B27 and N2 for 8-12 days...
June 14, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29898155/mandibular-anterior-crowding-normal-or-pathological
#13
Alberto Consolaro, Mauricio de Almeida Cardoso
The teeth become very close to each other when they are crowded, but their structures remain individualized and, in this situation, the role of the epithelial rests of Malassez is fundamental to release the EGF. The concept of tensegrity is fundamental to understand the responses of tissues submitted to forces in body movements, including teeth and their stability in this process. The factors of tooth position stability in the arch - or dental tensegrity - should be considered when one plans and perform an orthodontic treatment...
March 2018: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29897336/frmd8-promotes-inflammatory-and-growth-factor-signalling-by-stabilising-the-irhom-adam17-sheddase-complex
#14
Ulrike Künzel, Adam Graham Grieve, Yao Meng, Boris Sieber, Sally A Cowley, Matthew Freeman
Many intercellular signals are synthesised as transmembrane precursors that are released by proteolytic cleavage ('shedding') from the cell surface. ADAM17, a membrane-tethered metalloprotease, is the primary shedding enzyme responsible for the release of the inflammatory cytokine TNFα and several EGF receptor ligands. ADAM17 exists in complex with the rhomboid-like iRhom proteins, which act as cofactors that regulate ADAM17 substrate shedding. Here we report that the poorly characterised FERM domain-containing protein FRMD8 is a new component of iRhom2/ADAM17 sheddase complex...
June 13, 2018: ELife
https://www.readbyqxmd.com/read/29896251/overexpression-of-indoleamine-2-3-dioxygenase-contributes-to-the-repair-of-human-airway-epithelial-cells-inhibited-by-dexamethasone-via-affecting-the-mapk-erk-signaling-pathway
#15
Shanshan Jia, Pin Guo, Xiangjin Ge, Huanhuan Wu, Junhua Lu, Xiaofang Fan
Indoleamine 2, 3-dioxygenase (IDO) catalyzes the degradation of trytophan, which serves a key role in immune suppression via regulating the production of several metabolites. The present study aimed to explore the effects and mechanisms of IDO in the repair of human airway epithelium suppressed by dexamethasone (DEX). Cell viability, proliferation and migration were evaluated using a Cell Counting Kit-8 (CCK-8), 5(6)-carboxyfluorescein diacetate succinimidyl ester (CFSE) labeling, and wound-healing assay, respectively...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29895402/burn-wounds-in-the-young-versus-the-aged-patient-display-differential-immunological-responses
#16
Angel F Farinas, Ravinder Bamba, Alonda C Pollins, Nancy L Cardwell, Lillian B Nanney, Wesley P Thayer
BACKGROUND: Individuals in the geriatric age range are more prone than younger individuals to convert their partial thickness thermal burns into full thickness injuries. We hypothesized that this often observed clinical phenomenon is strongly related to differential local injury responses mediated by the immune system. MATERIALS & METHODS: Skin samples from areas with partial thickness thermal burns were obtained during routine excision and grafting procedures between post burn days 2-6...
June 9, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29894487/impact-of-chronic-sexual-abuse-and-depression-on-inflammation-and-wound-healing-in-the-female-reproductive-tract-of-hiv-uninfected-and-hiv-infected-women
#17
Mimi Ghosh, Jason Daniels, Maria Pyra, Monika Juzumaite, Mariel Jais, Kerry Murphy, Tonya N Taylor, Seble Kassaye, Lorie Benning, Mardge Cohen, Kathleen Weber
Sexual violence is associated with increased risk of HIV acquisition/transmission in women. Forced sex can result in physical trauma to the reproductive tract as well as severe psychological distress. However, immuno-biological mechanisms linking sexual violence and HIV susceptibility are incompletely understood. Using the Women's Interagency HIV Study repository, a total of 77 women were selected to form 4 groups, stratified by HIV serostatus, in the following categories: 1) no sexual abuse history and low depressive symptom score (below clinically significant cut-off, scores <16) (Control); 2) no sexual abuse history but high depressive symptom score, ≥16 (Depression); 3) chronic sexual abuse exposure and low depressive symptom score (Abuse); 4) chronic sexual abuse exposure and high depressive symptom score (Abuse+Depression)...
2018: PloS One
https://www.readbyqxmd.com/read/29893509/characterization-of-induced-pluripotent-stem-cell-derived-megakaryocyte-lysates-for-potential-regenerative-applications
#18
Anja Baigger, Dorothee Eicke, Yuliia Yuzefovych, Denys Pogozhykh, Rainer Blasczyk, Constanca Figueiredo
Recently, platelet-derived growth factors present in lysates became an extreme interest in the field of regenerative medicine such as in wound healing and as substitutes to foetal bovine serum in xeno-free cell culture systems. However, the generation of such platelet lysates completely depends on the availability of platelet donors. In this study, the possibility to use in vitro-generated megakaryocytes derived from induced pluripotent stem cells (iPSCs) as a cell source for typical platelet growth factors was investigated...
June 12, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29891015/anti-cancer-effects-of-kaempferia-parviflora-on-ovarian-cancer-skov3-cells
#19
Suthasinee Paramee, Siriwoot Sookkhee, Choompone Sakonwasun, Mingkwan Na Takuathung, Pitchaya Mungkornasawakul, Wutigri Nimlamool, Saranyapin Potikanond
BACKGROUND: Kaempferia parviflora (KP) is an herb found in the north of Thailand and used as a folk medicine for improving vitality. Current reports have shown the anti-cancer activities of KP. However, the anti-cancer effects of KP on highly aggressive ovarian cancer have not been investigated. Therefore, we determined the effects of KP on cell proliferation, migration, and cell death in SKOV3 cells. METHODS: Ovarian cancer cell line, SKOV3 was used to investigate the anti-cancer effect of KP extract...
June 11, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29890767/effect-of-different-preconditioning-regimens-on-the-expression-profile-of-murine-adipose-derived-stromal-stem-cells
#20
Patrick C Baer, Jürgen M Overath, Anja Urbschat, Ralf Schubert, Benjamin Koch, Asanke A Bohn, Helmut Geiger
Stem cell-based therapies require cells with a maximum regenerative capacity in order to support regeneration after tissue injury and organ failure. Optimization of this regenerative potential of mesenchymal stromal/stem cells (MSC) or their conditioned medium by in vitro preconditioning regimens are considered to be a promising strategy to improve the release of regenerative factors. In the present study, MSC were isolated from inguinal adipose tissue (mASC) from C57BL/6 mice, cultured, and characterized. Then, mASC were either preconditioned by incubation in a hypoxic environment (0...
June 10, 2018: International Journal of Molecular Sciences
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