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https://www.readbyqxmd.com/read/29218101/delta-notch-like-epidermal-growth-factor-related-receptor-dner-orchestrates-stemness-and-cancer-progression-in-prostate-cancer
#1
Lijun Wang, Qi Wu, Shan Zhu, Zhiyu Li, Jingping Yuan, Dehua Yu, Zhiliang Xu, Juanjuan Li, Shengrong Sun, Changhua Wang
DNER, Delta/Notch-like epidermal growth factor (EGF)-related receptor, is a neuron-specific transmembrane protein carrying extracellular EGF-like repeats. The function of DNER in prostate cancer has not been evaluated. Here, we showed that the upregulation of DNER is observed in various cancers, including prostate cancer. Knockdown of DNER in PC-3 cells inhibited cell proliferation, migration and invasion as well as tumorigenesis in PC-3 xenografts. DNER knockdown specifically inhibited cell growth in spheroids...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29216727/effect-of-egf-on-bax-bcl-2-and-fas-expression-in-ulcerous-disease-and-n87-cell-line
#2
F Soylemez, O I Ay, E Ay, E Altintas, C H Turkseven, M E Erdal
BACKGROUND: To evaluate the effect of epithelial growth factor (EGF) in primary culture of ulcer patients and N87 cell line on expressions of apoptotic genes. METHODS: Ulcer patients who attended Gastroenterology Clinic of Mersin University Medical Faculty were included in this study. Three different doses of EGF were applied to the primary culture of biopsy samples from ulcer patients and gastric cancer cell-line (ATCC-NCI-N87) . The expression levels of Bax, Bcl-2 and Fas genes were measured with quantitative real-time PCR (qRT-PCR)...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29212948/elevated-urinary-creld2-is-associated-with-endoplasmic-reticulum-stress-mediated-kidney-disease
#3
Yeawon Kim, Sun-Ji Park, Scott R Manson, Carlos Af Molina, Kendrah Kidd, Heather Thiessen-Philbrook, Rebecca J Perry, Helen Liapis, Stanislav Kmoch, Chirag R Parikh, Anthony J Bleyer, Ying Maggie Chen
ER stress has emerged as a signaling platform underlying the pathogenesis of various kidney diseases. Thus, there is an urgent need to develop ER stress biomarkers in the incipient stages of ER stress-mediated kidney disease, when a kidney biopsy is not yet clinically indicated, for early therapeutic intervention. Cysteine-rich with EGF-like domains 2 (CRELD2) is a newly identified protein that is induced and secreted under ER stress. For the first time to our knowledge, we demonstrate that CRELD2 can serve as a sensitive urinary biomarker for detecting ER stress in podocytes or renal tubular cells in murine models of podocyte ER stress-induced nephrotic syndrome and tunicamycin- or ischemia-reperfusion-induced acute kidney injury (AKI), respectively...
December 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/29212252/c-c-motif-chemokine-receptor-1-ccr1-is-a-target-of-the-egf-akt-mtor-stat3-signaling-axis-in-breast-cancer-cells
#4
Soon Young Shin, Da Hyun Lee, Jishin Lee, Chan Choi, Ji-Young Kim, Jeong-Seok Nam, Yoongho Lim, Young Han Lee
The CC motif chemokine receptor 1 (CCR1) has been implicated in tumor invasion and metastasis in numerous cancers. However, the detailed mechanism of CCR1 upregulation in metastatic tumor cells is poorly understood. The aim of this study was to clarify the regulatory mechanism underlying transcriptional activation of the CCR1 gene in response to epidermal growth factor (EGF) stimulation in breast cancer cells. CCR1 was highly expressed in human breast invasive ductal carcinoma (IDC) compared to adjacent normal tissues...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209441/pcsk9-signaling-pathways-and-their-potential-importance-in-clinical-practice
#5
REVIEW
Michał Wiciński, Jarosław Żak, Bartosz Malinowski, Gabriela Popek, Grzegorz Grześk
In the following review, authors described the structure and biochemical pathways of PCSK9, its involvement in LDL metabolism, as well as significances of proprotein convertase subtilisin/kexin type 9 targeted treatment. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism. Transcription and translation of PCSK9 is controlled by different nuclear factors, such as, SREBP and HNF1α. This review focuses on interactions between PCSK9 and LDL receptor, VLDLR, ApoER2, CD36, CD81, and others...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29209066/interaction-of-complement-defence-collagens-c1q-and-mannose-binding-lectin-with-bmp-1-tolloid-like-proteinases
#6
Monique Lacroix, Agnès Tessier, Chantal Dumestre-Pérard, Sandrine Vadon-Le Goff, Evelyne Gout, Leena Bruckner-Tuderman, Dimitra Kiritsi, Alexander Nyström, Sylvie Ricard-Blum, Catherine Moali, David J S Hulmes, Nicole M Thielens
The defence collagens C1q and mannose-binding lectin (MBL) are immune recognition proteins that associate with the serine proteinases C1r/C1s and MBL-associated serine proteases (MASPs) to trigger activation of complement, a major innate immune system. Bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases (BTPs) are metalloproteinases with major roles in extracellular matrix assembly and growth factor signalling. Despite their different functions, C1r/C1s/MASPs and BTPs share structural similarities, including a specific CUB-EGF-CUB domain arrangement found only in these enzymes that mediates interactions with collagen-like proteins, suggesting a possible functional relationship...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208567/phosphorylation-of-threonine-residues-on-shc-promotes-ligand-binding-and-mediates-crosstalk-between-mapk-and-akt-pathways-in-breast-cancer-cells
#7
K M Suen, C C Lin, C Seiler, R George, G Poncet-Montange, A B Biter, Z Ahmed, S T Arold, J E Ladbury
Scaffold proteins play important roles in regulating signalling network fidelity, the absence of which is often the basis for diseases such as cancer. In the present work, we show that the prototypical scaffold protein Shc is phosphorylated by the extracellular signal-regulated kinase, Erk. In addition, Shc threonine phosphorylation is specifically up-regulated in two selected triple-negative breast cancer (TNBC) cell lines. To explore how Erk-mediated threonine phosphorylation on Shc might play a role in the dysregulation of signalling events, we investigated how Shc affects pathways downstream of EGF receptor...
December 2, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29208350/efficient-differentiation-of-bone-marrow-mesenchymal-stem-cells-into-endothelial-cells-in%C3%A2-vitro
#8
Chengen Wang, Yuan Li, Min Yang, Yinghua Zou, Huihui Liu, Zeyin Liang, Yue Yin, Guochen Niu, Ziguang Yan, Bihui Zhang
OBJECTIVE: Endothelial cells (ECs) play an important role in neovascularisation, but are too limited in number for adequate therapeutic applications. Mesenchymal stem cells (MSCs) have the potential to differentiate into endothelial lineage cells, which makes them attractive candidates for therapeutic angiogenesis. The aim of this study was to investigate efficient differentiation of MSCs into ECs by inducing medium in vitro. METHODS: MSCs were isolated from bone marrow by density gradient centrifugation...
December 2, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29207668/genetic-or-pharmacologic-inhibition-of-egfr-ameliorates-sepsis-induced-aki
#9
Xuan Xu, Juan Wang, Ruhao Yang, Zheng Dong, Dongshan Zhang
Despite recent studies have demonstrated that the EGF receptor (EGFR) activation provided a renoprotective role during ischemic and folic acid-induced AKI, the role and regulation mechanism of EGFR in septic AKI remains unclear. Here, gefitinib, a highly selective EGFR inhibitor, abrogated LPS-induced phosphorylation of EGFR, ERK1/2, and STAT3 as well as expression of COX, eNOS, and proinflammatory cytokines in HK-2 cells. In addition, c-Src is an upstream of EGFR signaling pathway and mediates LPS-induced EGFR transactivation...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29203426/effects-of-structurally-stabilized-egf-and-bfgf-on-wound-healing-in-type-i-and-type-ii-diabetic-mice
#10
Seong Mi Choi, Kyoung-Mi Lee, Hyun Jung Kim, Ik Kyu Park, Hwi Ju Kang, Hang-Cheol Shin, Dawoon Baek, Yoorim Choi, Kwang Hwan Park, Jin Woo Lee
Diabetes mellitus comprises a multiple metabolic disorder that affects millions of people worldwide and consequentially poses challenges for clinical treatment. Among the various complications, diabetic ulcer constitutes the most prevalent associated disorder and leads to delayed wound healing. To enhance wound healing capacity, we developed structurally stabilized epidermal growth factor (ST-EGF) and basic fibroblast growth factor (ST-bFGF) to overcome limitations of commercially available EGF (CA-EGF) and bFGF (CA-bFGF), such as short half-life and loss of activity after loading onto a matrix...
December 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29201239/anxa1-affects-cell-proliferation-invasion-and-epithelial-mesenchymal-transition-of-oral-squamous-cell-carcinoma
#11
Ying-Ming Wan, Jing Tian, Ling Qi, Li-Mei Liu, Ning Xu
Annexin A1 (ANXA1) acts either as a tumor suppressor or an oncogene in different tumor types. Several clinical studies revealed that the expression of ANXA1 is associated with the pathologic differentiation grade in oral squamous cell carcinoma (OSCC) patients. However, the direct function of ANXA1 in OSCC progression has remained to be fully clarified. The present study was designed to investigate the role of ANXA1 in OSCC cell proliferation and invasion in vitro. Furthermore, whether ANXA1 was involved in transforming growth factor β1 (TGFβ1)/epidermal growth factor (EGF)-induced epithelial-mesenchymal transition (EMT) in OSCC was explored...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29201228/insect-tea-attenuates-hydrochloric-acid-and-ethanol-induced-mice-acute-gastric-injury
#12
Xin Zhao, Qiang Cheng, Yu Qian, Ruokun Yi, Lianjie Gu, Shanshan Wang, Jia-Le Song
The aim of the present study was to investigate the protective effect of insect tea on HCl/ethanol-induced gastric ulcers in ICR mice. The serum levels of vasoactive intestinal peptide, substance P, somatostatin, motilin and endothelin-1 in mice were assessed using commercial kits and gastric tissues of superoxide dismutase (SOD, nitric oxide (NO) and malondialdehyde (MDA) were determined using western blot analysis Insect tea significantly reduced HCl/ethanol-induced gastric juice secretion and increased the pH of gastric juice (P<0...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29201227/oridonin-enhances-in-vitro-anticancer-effects-of-lentinan-in-smmc-7721-human-hepatoma-cells-through-apoptotic-genes
#13
Tao Xu, Fa Jin, Keren Wu, Zhipeng Ye, Ning Li
The aim of the present study was to determine the ability of oridonin to enhance the anticancer activity of lentinan (LNT) in SMMC-7721 human hepatoma cells in vitro by using various techniques, including MTT, flow cytometry, quantitative PCR and western blot assays. The results demonstrated that 20 µg/ml was a non-toxic concentration of oridonin for L02 normal liver cells and SMMC-7721 cells, while 0-200 µg/ml of LNT only had anti-proliferative effects on SMMC-7721 cells. LNT at 100 and 200 µg/ml inhibited the growth of SMMC-7721 cells by 22...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29201160/egfr-and-cortactin-markers-for-potential-double-target-therapy-in-oral-squamous-cell-carcinoma
#14
Oliver Bissinger, Andreas Kolk, Enken Drecoll, Melanie Straub, Christina Lutz, Klaus-Dietrich Wolff, Carolin Götz
Survival periods of patients following surgical therapy of oral squamous cell carcinoma (OSCC) have previously been demonstrated to decrease over recent decades. Epidermal growth factor receptor (EGFR) and Cortactin are molecular markers that are important in tumour progression and development, and interact within the EGF pathway. Although EGFR antibody therapy exists, sufficient efforts for increased survival are still lacking due to the present limited response rates. The aim of the present study was to examine the association between EGFR and Cortactin expression on survival rates of OSCC patients and to determine whether EGFR and Cortactin expression levels are associated with advanced tumor sizes and lymphnode-metastases...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29196961/%C3%AE-7-nachr-activation-has-an-opposite-effect-on-healing-of-covered-and-uncovered-wounds
#15
Jiao-Yong Li, Shu-Kun Jiang, Lin-Lin Wang, Meng-Zhou Zhang, Shuai Wang, Zhen-Fei Jiang, Yu-Li Liu, Hao Cheng, Miao Zhang, Rui Zhao, Da-Wei Guan
The α7 nicotinic acetylcholine receptor (α7-nAChR) is associated with inflammation, re-epithelialization, and angiogenesis in wound healing process. A recent study demonstrated that PNU-282987, a selective agonist of α7-nAChR, accelerates the repair of diabetic excisional wounds. Whether α7-nAChR activation promotes non-diabetic wounds healing is unknown. The aim of this study was to evaluate the effects of α7-nAChR activation on non-diabetic wound healing. The effects were evaluated in two wound models...
December 1, 2017: Inflammation
https://www.readbyqxmd.com/read/29191924/both-autocrine-signaling-and-paracrine-signaling-of-hb-egf-enhance-ocular-neovascularization
#16
Yuki Inoue, Masamitsu Shimazawa, Shinsuke Nakamura, Shinsuke Takata, Yuhei Hashimoto, Hiroshi Izawa, Tomomi Masuda, Kazuhiro Tsuruma, Tomohisa Sakaue, Hironao Nakayama, Shigeki Higashiyama, Hideaki Hara
OBJECTIVE: The incidence of blindness is increasing because of the increase in abnormal ocular neovascularization. Anti-VEGF (vascular endothelial growth factor) therapies have led to good results, although they are not a cure for the blindness. The purpose of this study was to determine what role HB-EGF (heparin-binding epidermal growth factor-like growth factor) plays in ocular angiogenesis. APPROACH AND RESULTS: We examined the role played by HB-EGF in ocular neovascularization in 2 animal models of neovascularization: laser-induced choroidal neovascularization (CNV) and oxygen-induced retinopathy...
November 30, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29191392/cold-atmospheric-plasma-cap-activates-angiogenesis-related-molecules-in-skin-keratinocytes-fibroblasts-and-endothelial-cells-and-improves-wound-angiogenesis-in-an-autocrine-and-paracrine-mode
#17
Stephanie Arndt, Petra Unger, Mark Berneburg, Anja-Katrin Bosserhoff, Sigrid Karrer
BACKGROUND: Cold atmospheric plasma (CAP) emerged as a novel therapeutic field with applications developed for bacterial sterilization, wound healing and cancer treatment. For clinical implementation it is important to know how CAP works and which molecular changes occur after the CAP treatment. Vascularization is an important step during wound healing, however, the effects of CAP on wound angiogenesis are not well examined so far. Furthermore, it has not been investigated, whether CAP primarily affects endothelial cells directly or via paracrine mechanisms to modulate the vasculature...
November 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29189189/selective-suppression-of-cyp3a4-mrna-and-enzyme-activity-by-epidermal-growth-factor-in-plated-human-hepatocytes
#18
George Zhang, Duan Wang, Thuy Ho, Robert J Clark, David M Stresser
BACKGROUND: Epidermal growth factor (EGF) is a well-known mitogen that has importance in cell proliferation and differentiation. These properties have led to the common use of EGF as an additive to some cell culture media. EGF has been previously shown to modulate constitutive cytochrome P450 (CYP) expression in vitro. OBJECTIVES: To assess the influence of EGF on the basal and induced expression of CYP3A4, CYP1A2 and CYP2B6 in plated human hepatocytes. METHODS: Human hepatocytes from 3 donors were treated with EGF with and without in the presence of positive control inducers...
November 28, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/29188436/epithelial-separation-theory-for-post-tonsillectomy-secondary-hemorrhage-evidence-in-a-mouse-model-and-potential-heparin-binding-epidermal-growth-factor-like-growth-factor-therapy
#19
Daniel M Beswick, Chloe Santa Maria, Noel F Ayoub, Robson Capasso, Peter Luke Santa Maria
OBJECTIVE: To provide histological evidence to investigate a theory for post-tonsillectomy secondary hemorrhage (PTH) in a mouse model and to evaluate the potential for heparin-binding epidermal growth factor-like growth factor (HB-EGF) treatment on wound healing in this model. METHODS: A prospective randomized single-blinded cohort study. A uniform tongue wound was created in 84 mice (day 0). Mice were randomized to HB-EGF (treatment, n = 42) or saline (control, n = 42)...
November 29, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29185160/exogenous-growth-factors-enhance-the-expression-of-cola1-cola3-and-elastin-in-fibroblasts-via-activating-mapk-signaling-pathway
#20
TianDing Shen, Kai Gao, Yong Miao, ZhiQi Hu
Exogenous growth factors could accelerate the process of wound healing. However, the underlying mechanisms have not been clearly clarified. The aim of the present study was to investigate the effect of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on the expression of type I collagen (cola1), type III collagen (cola3), and Elastin in fibroblasts, which are widely expressed in fibroblasts and promote the function of fibroblasts. We measured the levels of cola1 and cola3 in human fibroblast cells cultured in medium containing EGF or bFGF at concentrations ranging from 0...
November 28, 2017: Molecular and Cellular Biochemistry
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