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Nested case-control study

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https://www.readbyqxmd.com/read/28732327/prediagnostic-serum-calcium-and-albumin-and-ovarian-cancer-a-nested-case-control-study-in-the-norwegian-janus-serum-bank-cohort
#1
Gary G Schwartz, Steinar Tretli, Linda Vos, Trude E Robsahm
BACKGROUND: Women with higher serum calcium may be more likely to be diagnosed and die of ovarian cancer. We evaluated that finding in a large, prospective cohort. METHODS: We conducted a nested case-control study using a population-based biobank from Norway. We compared 202 ovarian cancer cases and 202 controls, matched for age, date at blood draw, and county of residence, with respect to serum calcium and albumin, adjusted for anthropometric variables. We evaluated risks using the entire follow-up period as well as 2-15 years and 16-25 years ("early" and "late", respectively)...
July 18, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28729251/inclusion-of-a-genetic-risk-score-into-a-validated-risk-prediction-model-for-colorectal-cancer-in-japanese-men-improves-performance
#2
Motoki Iwasaki, Sachiko Tanaka-Mizuno, Aya Kuchiba, Taiki Yamaji, Norie Sawada, Atsushi Goto, Taichi Shimazu, Shizuka Sasazuki, Hansong Wang, Loic Le Marchand, Shoichiro Tsugane
We previously developed and validated a risk prediction model for colorectal cancer in Japanese men using modifiable risk factors. To further improve risk prediction, we evaluated the degree of improvement obtained by adding a genetic risk score (GRS) using genome-wide association study (GWAS)-identified risk variants to our validated model. We examined the association between 36 risk variants identified by GWAS and colorectal cancer risk using a weighted Cox proportional hazard model in a nested case-control study within the Japan Public Health Center-based Prospective Study...
July 20, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28723686/population-based-study-on-the-epidemiology-of-m%C3%A3-ni%C3%A3-re-s-disease
#3
Saskia G Bruderer, Daniel Bodmer, Nadja A Stohler, Susan S Jick, Christoph R Meier
BACKGROUND AND OBJECTIVE: Ménière's disease (MD) is a disorder of the inner ear typically showing recurrent acute episodes of vertigo, hearing loss, and tinnitus. Epidemiologic studies on MD are scarce. We assessed the incidence rates (IRs) of MD and describe the characteristics of MD cases, comparing them to control patients without recorded evidence of MD. STUDY DESIGN: We conducted a retrospective population-based follow-up study and a nested case-control analysis using data from the UK-based Clinical Practice Research Datalink...
July 20, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28723492/validation-of-gene-expression-signatures-to-identify-low-risk-clear-cell-renal-cell-carcinoma-patients-at-higher-risk-for-disease-related-death
#4
Mansi Parasramka, Daniel J Serie, Yan W Asmann, Jeanette E Eckel-Passow, Erik P Castle, Melissa L Stanton, Brad C Leibovich, Robert Houston Thompson, E Aubrey Thompson, Alexander S Parker, Thai H Ho, Richard W Joseph
BACKGROUND: Approximately 5-10% of patients with "low-risk" clear cell renal cell carcinoma (ccRCC), as stratified by externally validated clinicopathologic prognostic algorithms, eventually have disease relapse and die. Improving prognostic algorithms for these low-risk patients could help to provide improved individualized surveillance recommendations. OBJECTIVE: To identify genes that are differentially expressed in patients with low-risk ccRCC who did and did not die of their disease...
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28720108/early-pregnancy-sex-steroids-during-primiparous-pregnancies-and-maternal-breast-cancer-a-nested-case-control-study-in-the-northern-sweden-maternity-cohort
#5
Renée T Fortner, Eglé Tolockiene, Helena Schock, Husam Oda, Hans-Åke Lakso, Göran Hallmans, Rudolf Kaaks, Paolo Toniolo, Anne Zeleniuch-Jacquotte, Kjell Grankvist, Eva Lundin
BACKGROUND: Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones. METHODS: We conducted a nested case-control study in the Northern Sweden Maternity Cohort (1975-2007). Eligible women had provided a blood sample in the first 20 weeks of gestation during a primiparous pregnancy leading to a term delivery. The current study includes 223 cases and 417 matched controls (matching factors: age at and date of blood collection)...
July 18, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28717885/risk-of-severe-acute-liver-injury-among-patients-with-brain-cancer-treated-with-temozolomide-a-nested-case-control-study-using-the-healthcore-integrated-research-database
#6
Vibha C A Desai, Scott C Quinlan, Anne C Deitz, Jinghua He, Crystal N Holick, Stephan Lanes
Temozolomide (TMZ) is used to treat adult patients with glioblastoma multiforme (GBM). Cases of hepatotoxicity have been reported among patients using TMZ. The objective of the study was to assess the relation, if any, between exposure to TMZ and serious acute liver injury (SALI). We used the HealthCore Integrated Research Database to perform a case-control study nested within a retrospective cohort of adult patients aged 18-100 years with at least two diagnoses of brain cancer anytime between 2006 and 2014...
July 17, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28717513/unexpected-intensive-care-transfer-of-admitted-patients-with-severe-sepsis
#7
Gabriel Wardi, Arvin R Wali, Julian Villar, Vaishal Tolia, Christian Tomaszewski, Christian Sloane, Peter Fedullo, Jeremy R Beitler, Matthew Nolan, Daniel Lasoff, Rebecca E Sell
BACKGROUND: Patients with severe sepsis generally respond well to initial therapy administered in the emergency department (ED), but a subset later decompensate and require unexpected transfer to the intensive care unit (ICU). This study aimed to identify clinical factors that can predict patients at increased risk for delayed transfer to the ICU and the association of delayed ICU transfer with mortality. METHODS: This is a nested case-control study in a prospectively collected registry of patients with severe sepsis and septic shock at two EDs...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28710942/parental-psychopathology-and-offspring-attention-deficit-hyperactivity-disorder-in-a-nationwide-sample
#8
Petteri Joelsson, Roshan Chudal, Jaakko Uotila, Auli Suominen, Dan Sucksdorff, David Gyllenberg, Andre Sourander
OBJECTIVE: To study the associations between a wide range of parental psychiatric disorders and offspring attention-deficit/hyperactivity disorder (ADHD). METHOD: This study is based on a nested case-control design. The association between parental registered psychiatric diagnoses and offspring ADHD was examined adjusting for socioeconomic and prenatal factors. Data was linked from Finnish nationwide registers. The cases (n = 10,409) were all the children born between years 1991 and 2005 in Finland and diagnosed with ADHD by the end of 2011...
July 4, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28710217/causes-of-death-in-patients-with-itai-itai-disease-suffering-from-severe-chronic-cadmium-poisoning-a-nested-case-control-analysis-of-a-follow-up-study-in-japan
#9
Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono, Kazuhiro Nogawa, Teruhiko Kido
OBJECTIVE: To clarify the causes of deaths among patients with Itai-itai disease and severe cadmium (Cd) poisoning. DESIGN: Nested case-control analysis of a population-based cohort study. SETTING: Database of patients with Itai-itai disease and residents of Cd-polluted areas, maintained by the Ministry of Environment, Japan. PARTICIPANTS: Subjects included 142 women with Itai-itai disease, 111 women with Cd-induced renal tubular dysfunction and 253 controls matched for sex, age and occupation...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28707432/mechanisms-of-breast-cancer-risk-in-shift-workers-association-of-telomere-shortening-with-the-duration-and-intensity-of-night-work
#10
Johanna Samulin Erdem, Heidi Ødegaard Notø, Øivind Skare, Jenny-Anne S Lie, Marte Petersen-Øverleir, Edyta Reszka, Beata Pepłońska, Shanbeh Zienolddiny
Occupational factors such as shiftwork and especially night work that involves disruption of the circadian rhythm may contribute to increased breast cancer risk. Circadian disruption may also affect telomere length (TL). While short TL generally is associated with increased cancer risk, its association with breast cancer risk is inconclusive. We suggest that working schedules might be an important factor in assessment of effects of TL on breast cancer risk. Moreover, telomere shortening might be a potential mechanism for night work-related breast cancer...
July 14, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28704670/cryo-conditioned-rocky-coast-systems-a-case-study-from-wilczekodden-svalbard
#11
M C Strzelecki, M Kasprzak, M Lim, Z M Swirad, M Jaskólski, Ł Pawłowski, P Modzel
This paper presents the results of an investigation into the processes controlling development of a cryo-conditioned rock coast system in Hornsund, Svalbard. A suite of nested geomorphological and geophysical methods have been applied to characterise the functioning of rock cliffs and shore platforms influenced by lithological control and geomorphic processes driven by polar coast environments. Electrical resistivity tomosgraphy (ERT) surveys have been used to investigate permafrost control on rock coast dynamics and reveal the strong interaction with marine processes in High Arctic coastal settings...
July 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28701495/neurodegenerative-and-psychiatric-diseases-among-families-with-amyotrophic-lateral-sclerosis
#12
Elisa Longinetti, Daniela Mariosa, Henrik Larsson, Weimin Ye, Caroline Ingre, Catarina Almqvist, Paul Lichtenstein, Fredrik Piehl, Fang Fang
OBJECTIVE: To estimate risks of neurodegenerative and psychiatric diseases among patients with amyotrophic lateral sclerosis (ALS) and their families. METHODS: We conducted a register-based nested case-control study during 1990-2013 in Sweden to assess whether patients with ALS had higher risks of other neurodegenerative and psychiatric diseases before diagnosis. We included 3,648 patients with ALS and 36,480 age-, sex-, and county of birth-matched population controls...
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28701332/circulating-rankl-and-rankl-opg-and-breast-cancer-risk-by-er-and-pr-subtype-results-from-the-epic-cohort
#13
Danja Sarink, Helena Schock, Theron Johnson, Kim Overvad, Marianne Holm, Anne Tjonneland, Marie-Christine Boutron-Ruault, Mathilde His, Marina Kvaskoff, Heiner Boeing, Pagona Lagiou, Eleni-Maria Papatesta, Antonia Trichopoulou, Domenico Palli, Valeria Pala, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, H B As Bueno-de-Mesquita, Carla H van Gils, Petra H Peeters, Elisabete Weiderpass, Antonio Agudo, Maria-Jose Sanchez, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Kay-Tee Khaw, Ruth C Travis, Laure Dossus, Marc J Gunter, Sabina Rinaldi, Melissa A Merritt, Elio Riboli, Rudolf Kaaks, Renee T Fortner
Receptor activator of nuclear factor kappa-B (RANK)-RANK ligand (RANKL) signaling promotes mammary tumor development in experimental models. Circulating concentrations of soluble RANKL (sRANKL) may influence breast cancer risk via activation of RANK signaling; this may be modulated by osteoprotegerin (OPG), the decoy receptor for RANKL. sRANKL and breast cancer risk by hormone receptor subtype has not previously been investigated. <p>A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort...
July 12, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28699189/human-papillomavirus-infects-placental-trophoblast-and-hofbauer-cells-but-appears-not-to-play-a-causal-role-in-miscarriage-and-preterm-labor
#14
Lea Maria Margareta Ambühl, Anne Katrine Leonhard, Carina Widen Zakhary, Annemette Jørgensen, Jan Blaakaer, Karen Dybkaer, Ulrik Baandrup, Niels Uldbjerg, Suzette Sørensen
INTRODUCTION: Recently, an association between human papillomavirus (HPV) infection and both spontaneous abortion and spontaneous preterm delivery was suggested. However, the reported HPV prevalence in pregnant women varies considerably and reliable conclusions are difficult. We aimed to investigate HPV infection in placental tissue of a Danish study cohort. Furthermore, we studied the cellular localization of HPV. MATERIAL AND METHODS: In this prospective case-control study, placental tissue was analyzed for HPV infection by nested PCR in the following four study groups: full-term delivery (n=103), spontaneous preterm delivery (n=69), elective abortion (n=54), and spontaneous abortion (n=44)...
July 12, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28697417/tumor-characteristics-and-family-history-in-relation-to-mammographic-density-and-breast-cancer-the-french-e3n-cohort
#15
Gertraud Maskarinec, Laureen Dartois, Suzette Delaloge, John Hopper, Françoise Clavel-Chapelon, Laura Baglietto
BACKGROUND: Mammographic density is a known heritable risk factor for breast cancer, but reports how tumor characteristics and family history may modify this association are inconsistent. METHODS: Dense and total breast areas were assessed using Cumulus™ from pre-diagnostic mammograms for 820 invasive breast cancer cases and 820 matched controls nested within the French E3N cohort study. To allow comparisons across models, percent mammographic density (PMD) was standardized to the distribution of the controls...
July 8, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28697060/mortality-among-hardmetal-production-workers-uk-cohort-and-nested-case-control-studies
#16
Damien M McElvenny, Laura A MacCalman, Anne Sleeuwenhoek, Alice Davis, Brian G Miller, Carla Alexander, Hilary Cowie, John W Cherrie, Kathleen J Kennedy, Nurtan A Esmen, Sarah D Zimmerman, Jeanine M Buchanich, Gary M Marsh
OBJECTIVE: The aim of this study was to characterize the mortality at two hardmetal production factories in the United Kingdom as part of an international study. METHODS: Standardized mortality ratios (SMRs) were calculated on the basis of mortality rates for England and Wales, and local rates. A nested case-control study of lung cancer was undertaken. RESULTS: The cohort comprised 1538 workers, with tracing complete for 94.4%. All-cause mortality was statistically significantly low for all cancers and nonmalignant respiratory disease, and for lung cancer was nonsignificantly low...
July 10, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28695906/no-association-between-proton-pump-inhibitor-use-and-risk-of-alzheimer-s-disease
#17
Heidi Taipale, Anna-Maija Tolppanen, Miia Tiihonen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen
OBJECTIVES: The objective of the study was to investigate whether proton pump inhibitor (PPI) use is associated with an increased risk of clinically verified Alzheimer's disease (AD). METHODS: A Finnish nationwide nested case-control study MEDALZ includes all community-dwelling individuals with newly diagnosed AD during 2005-2011 (N=70,718), and up to four age-, sex-, and region of residence-matched comparison individuals for each case (N=282,858). Data were extracted from Finnish nationwide health-care registers...
July 11, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28693443/association-of-benzodiazepine-and-z-drug-use-with-the-risk-of-hospitalisation-for-fall-related-injuries-among-older-people-a-nationwide-nested-case-control-study-in-taiwan
#18
Nan-Wen Yu, Pei-Jung Chen, Hui-Ju Tsai, Chih-Wan Huang, Yu-Wen Chiu, Wen-Ing Tsay, Jui Hsu, Chia-Ming Chang
BACKGROUND: Non-benzodiazepine hypnotics (Z-drugs) are advocated to be safer than benzodiazepines (BZDs). This study comprehensively investigated the association of BZD and Z-drug usage with the risk of hospitalisation for fall-related injuries in older people. METHODS: This study used the Taiwan National Health Insurance Database with a nested matched case-control design. We identified 2238 elderly patients who had been hospitalised for fall-related injuries between 2003 and 2012...
July 11, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28692646/biomarkers-for-predicting-type-2-diabetes-development-can-metabolomics-improve-on-existing-biomarkers
#19
Otto Savolainen, Björn Fagerberg, Mads Vendelbo Lind, Ann-Sofie Sandberg, Alastair B Ross, Göran Bergström
AIM: The aim was to determine if metabolomics could be used to build a predictive model for type 2 diabetes (T2D) risk that would improve prediction of T2D over current risk markers. METHODS: Gas chromatography-tandem mass spectrometry metabolomics was used in a nested case-control study based on a screening sample of 64-year-old Caucasian women (n = 629). Candidate metabolic markers of T2D were identified in plasma obtained at baseline and the power to predict diabetes was tested in 69 incident cases occurring during 5...
2017: PloS One
https://www.readbyqxmd.com/read/28692645/benzodiazepine-and-z-drug-use-and-risk-of-pneumonia-in-patients-with-chronic-kidney-disease-a-population-based-nested-case-control-study
#20
Meng-Ting Wang, Yun-Han Wang, Hsin-An Chang, Chen-Liang Tsai, Ya-Sung Yang, Chen Wei Lin, Cheng-Chin Kuo, Yu-Juei Hsu
BACKGROUND: Concerns were raised about pneumonia development from benzodiazepines (BZDs) and Z-drugs, but direct evidence is limited, conflicting and without examining the highly susceptible patients with chronic kidney disease (CKD) nor specifying the risk for different drug utilizations. This study aimed to investigate whether use of BZDs and Z-drugs was each associated with an increased risk of pneumonia in a CKD population. METHODS: We performed a nested case-control study of 36,880 CKD patients analyzing the Taiwan National Health Insurance Database between 01/1/2000 and 12/31/2011...
2017: PloS One
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