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Nested case-control study

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https://www.readbyqxmd.com/read/28647687/overweight-obesity-and-survival-after-stroke-in-the-framingham-heart-study
#1
Hugo J Aparicio, Jayandra J Himali, Alexa S Beiser, Kendra L Davis-Plourde, Ramachandran S Vasan, Carlos S Kase, Philip A Wolf, Sudha Seshadri
BACKGROUND: We investigated how body weight affects survival after stroke, leveraging the availability of multiple prestroke body mass index (BMI) measurements and using a nested case-control design in a community-based sample. METHODS AND RESULTS: We compared all-cause mortality in participants stratified by prestroke weight. Separate analyses were performed for ischemic stroke and all stroke and for age-, sex-, and BMI category-matched stroke-free controls. Participants were grouped into BMI categories and followed for up to 10 years...
June 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28645427/antidiabetic-medication-statins-and-the-risk-of-endometrioid-endometrial-cancer-in-patients-with-type-2-diabetes
#2
Reetta Arima, Mikko Marttila, Ari Hautakoski, Martti Arffman, Reijo Sund, Pirjo Ilanne-Parikka, Jenni Kangaskokko, Esa Läärä, Ulla Puistola, Marianne Hinkula
OBJECTIVE: To gain further evidence of an association between the incidence of endometrial cancer (EC) and the use of metformin, other antidiabetic medication (ADM) and statins in women with type 2 diabetes (T2D). METHODS: A retrospective cohort of 92,366 women with newly diagnosed T2D was obtained from a diabetes register (FinDM). 590 endometrioid ECs were observed during the follow-up time. Poisson regression was utilized to estimate the hazard ratios (HRs) with 95% confidence intervals (95% CIs) of the endometrioid EC in relation to the use of metformin, other oral ADM, insulin and statins...
June 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28643021/the-effect-of-14-3-3%C3%AE-expression-on-tamoxifen-resistance-and-breast-cancer-recurrence-a-danish-population-based-study
#3
Jake E Thistle, Ylva Hellberg, Kristina Mortensen, Stephen Hamilton-Dutoit, Anders Kjærsgaard, Deirdre Cronin-Fenton, Henrik Toft Sørensen, Timothy L Lash
PURPOSE: Overexpression of 14-3-3ζ has been linked to breast cancer recurrence in several studies, including studies assessing its effect on tamoxifen resistance. The study was performed to estimate the effect of 14-3-3ζ and differentiate potential prognostic or predictive utility. METHODS: A case-control study, nested in a population of 11,251 females residing on the Jutland Peninsula of Denmark, was performed. Participants were aged 35-69, diagnosed with stage I, II, or III breast cancer between 1985 and 2001, and registered with the Danish Breast Cancer Cooperative Group...
June 22, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28643020/association-between-lifestyle-menstrual-reproductive-history-and-histological-factors-and-risk-of-breast-cancer-in-women-biopsied-for-benign-breast-disease
#4
Rhonda Arthur, Yihong Wang, Kenny Ye, Andrew G Glass, Mindy Ginsberg, Olivier Loudig, Thomas Rohan
PURPOSE: Women with benign breast disease (BBD) have an increased risk of subsequent breast cancer. However, whether conventional breast cancer risk factors influence risk of breast cancer among women with BBD is unclear. In this study, we investigated the associations of lifestyle, menstrual/reproductive, and histological factors with risk of breast cancer among women biopsied for BBD. METHODS: We conducted a case-control study, nested within a cohort of 15,395 women biopsied for BBD at Kaiser Permanente Northwest between 1971 and 2006...
June 22, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28642459/meta-analysis-of-soy-consumption-and-gastrointestinal-cancer-risk
#5
Demin Lu, Chi Pan, Chenyang Ye, Huijie Duan, Fei Xu, Li Yin, Wei Tian, Suzhan Zhang
Soy consumption has received considerable attention for its potential role in reducing cancer incidence and mortality. However, its effects on gastrointestinal (GI) cancer are controversial. Therefore, we performed a meta-analysis to evaluate the association between soy consumption and gastrointestinal cancer risk by searching for prospective studies in PubMed, Web of Science, EMBASE and the reference lists of the included articles. The study-specific odds ratio (OR), relative risk (RR) or hazard ratio (HR) estimates and 95% confidence intervals (CIs) were pooled using either a fixed-effect or random-effect model...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28637727/a-protocol-for-prospective-studies-of-25-hydroxyvitamin-d-leptin-and-body-mass-index-in-relation-to-cutaneous-melanoma-incidence-and-survival
#6
Jo Steinson Stenehjem, Tom K Grimsrud, Judith R Rees, Linda Vos, Ronnie Babigumira, Marit B Veierød, Trude Eid Robsahm
INTRODUCTION: The incidence and mortality rates of cutaneous melanoma (CM) are increasing among fair-skinned populations worldwide. Ultraviolet radiation (UVR) is the principal risk factor for CM, but is also the main source of 25-hydroxyvitamin D (25(OH)D), which has been associated with reduced risk and better prognosis of some cancer types. However, both low and high 25(OH)D levels have been associated with increased risk of CM. Obesity as measured by body mass index (BMI) is associated with risk of several cancers and has also been suggested as a risk factor for CM, and may also be related to insufficient 25(OH)D and/or high leptin levels...
June 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28637686/high-serum-phospholipid-dihomo-%C3%AE-linoleic-acid-concentration-and-low-%C3%AE-5-desaturase-activity-are-associated-with-increased-risk-of-type-2-diabetes-among-japanese-adults-in-the-hitachi-health-study
#7
Shamima Akter, Kayo Kurotani, Masao Sato, Takuya Hayashi, Keisuke Kuwahara, Yumi Matsushita, Tohru Nakagawa, Maki Konishi, Toru Honda, Shuichiro Yamamoto, Takeshi Hayashi, Mitsuhiko Noda, Tetsuya Mizoue
Background: The association between the circulating fatty acid (FA) composition and type 2 diabetes (T2D) has been reported in Western populations, but evidence is scarce among Asian populations, including Japanese, who consume large amounts of fish.Objective: The objective of the present study was to prospectively examine the association between circulating concentrations of individual FAs and T2D incidence among Japanese adults.Methods: We conducted a nested case-control study in a cohort of 4754 employees, aged 34-69 y, who attended a comprehensive health checkup in 2008-2009 and donated blood samples for the Hitachi Health Study...
June 21, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28636844/clonal-hematopoiesis-and-risk-of-atherosclerotic-cardiovascular-disease
#8
Siddhartha Jaiswal, Pradeep Natarajan, Alexander J Silver, Christopher J Gibson, Alexander G Bick, Eugenia Shvartz, Marie McConkey, Namrata Gupta, Stacey Gabriel, Diego Ardissino, Usman Baber, Roxana Mehran, Valentin Fuster, John Danesh, Philippe Frossard, Danish Saleheen, Olle Melander, Galina K Sukhova, Donna Neuberg, Peter Libby, Sekar Kathiresan, Benjamin L Ebert
Background Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of an expanded somatic blood-cell clone in persons without other hematologic abnormalities, is common among older persons and is associated with an increased risk of hematologic cancer. We previously found preliminary evidence for an association between CHIP and atherosclerotic cardiovascular disease, but the nature of this association was unclear. Methods We used whole-exome sequencing to detect the presence of CHIP in peripheral-blood cells and associated such presence with coronary heart disease using samples from four case-control studies that together enrolled 4726 participants with coronary heart disease and 3529 controls...
June 21, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28634824/association-of-parkinsonism-or-parkinson-disease-with-polypharmacy-in-the-year-preceding-diagnosis-a-nested-case-control-study-in-south-korea
#9
Hae-Young Park, Ji-Won Park, Hyun Soon Sohn, Jin-Won Kwon
INTRODUCTION: Published studies on the association between polypharmacy and parkinsonism or Parkinson disease are very limited. OBJECTIVE: The objective of this study was to investigate whether polypharmacy is associated with parkinsonism or Parkinson disease in elderly patients. METHODS: From a South Korean national health insurance sample cohort database for 2002-2013, we matched parkinsonism cases (defined by diagnosis codes for parkinsonism/Parkinson disease) and Parkinson disease cases (patients who had records for both Parkinson disease diagnosis and anti-Parkinson disease drug prescriptions) with controls...
June 20, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28634123/clinical-utility-of-chromosomal-aneusomy-in-individuals-at-high-risk-of-lung-cancer
#10
Anna E Barón, Severine Kako, William J Feser, Heather Malinowski, Daniel Merrick, Kavita Garg, Stephen Malkoski, Shannon Pretzel, Jill M Siegfried, Wilbur A Franklin, York Miller, Holly J Wolf, Marileila Varella-Garcia
INTRODUCTION: Low dose CT screening for lung cancer has a high false positive rate with frequent discovery of indeterminate pulmonary nodules. Noninvasive biomarkers are needed to reduce false positives and improve risk stratification. A retrospective longitudinal evaluation was performed to assess chromosomal aneusomy in sputum via fluorescence in situ hybridization (CA-FISH) in four nested case-control studies. METHODS: ROC analysis resulted in two grouped cohorts: High Risk (CO High Risk and CO Nodule; 68 Cases, 69 controls) and Screening (ACRIN/NLST and PLuSS; 97 Cases, 185 controls)...
June 17, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28629245/obstetric-risk-factors-for-poor-neonatal-adaptation-at-birth
#11
Francesca Crovetto, Monica Fumagalli, Agnese De Carli, Giulia Maria Baffero, Silvia Nozza, Francesca Dessimone, Patrizia Vergani, Luigi Fedele, Fabio Mosca, Barbara Acaia
PURPOSE: To identify obstetric risk factors of delivering a neonate with poor neonatal adaptation at birth. MATERIAL AND METHODS: Nested-case control study. Poor neonatal adaptation was defined for presence of at least: umbilical cord artery pH < 7.10, base deficit ≥ 12 mmol/L, Apgar score at 1' ≤ 5. Controls were selected from the same population and matched with cases. The association between clinical parameters and poor neonatal adaptation was analyzed by logistic regression...
June 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28628401/dietary-red-and-processed-meat-intake-and-markers-of-adiposity-and-inflammation-the-multiethnic-cohort-study
#12
Weiwen Chai, Yukiko Morimoto, Robert V Cooney, Adrian A Franke, Yurii B Shvetsov, Loïc Le Marchand, Christopher A Haiman, Laurence N Kolonel, Marc T Goodman, Gertraud Maskarinec
OBJECTIVE: The potential influence of dietary factors on inflammation is important for cancer prevention. Utilizing data from control participants (312 men, 911 women) in 2 nested case-control studies of cancer within the Multiethnic Cohort, we examined the associations of red and processed meat intake with serum levels of leptin, adiponectin, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 and the mediator effect of body mass index (BMI) on the above associations (if present)...
June 19, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28624977/interaction-of-mammographic-breast-density-with-menopausal-status-and-postmenopausal-hormone-use-in-relation-to-the-risk-of-aggressive-breast-cancer-subtypes
#13
Lusine Yaghjyan, Rulla M Tamimi, Kimberly A Bertrand, Christopher G Scott, Matthew R Jensen, V Shane Pankratz, Kathy Brandt, Daniel Visscher, Aaron Norman, Fergus Couch, John Shepherd, Bo Fan, Yunn-Yi Chen, Lin Ma, Andrew H Beck, Steven R Cummings, Karla Kerlikowske, Celine M Vachon
PURPOSE: We examined the associations of mammographic breast density with breast cancer risk by tumor aggressiveness and by menopausal status and current postmenopausal hormone therapy. METHODS: This study included 2596 invasive breast cancer cases and 4059 controls selected from participants of four nested case-control studies within four established cohorts: the Mayo Mammography Health Study, the Nurses' Health Study, Nurses' Health Study II, and San Francisco Mammography Registry...
June 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28624014/can-routine-chest-radiography-be-used-to-diagnose-mild-copd-a-nested-case-control-study
#14
A M den Harder, A M Snoek, T Leiner, W J Suyker, L M de Heer, R P J Budde, J W J Lammers, P A de Jong, M J A Gondrie
OBJECTIVES: To determine whether mild stage chronic obstructive pulmonary disease (COPD) can be detected on chest radiography without substantial overdiagnosis. METHODS: A retrospective nested case-control study (case:control, 1:1) was performed in 783 patients scheduled for cardiothoracic surgery who underwent both spirometry and a chest radiograph preoperative. Diagnostic accuracy of chest radiography for diagnosing mild COPD was investigated using objective measurements and overall appearance specific for COPD on chest radiography...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28620871/lipophilic-statins-and-the-risk-of-intracranial-hemorrhage-following-ischemic-stroke-a-population-based-study
#15
Kieran L Quinn, Erin M Macdonald, Muhammad M Mamdani, Christina Diong, David N Juurlink
BACKGROUND: Statins are commonly prescribed for the secondary prevention of ischemic stroke, but there is conflicting evidence as to whether they increase the risk of intracranial hemorrhage. Lipophilic statins cross the blood-brain barrier more freely than hydrophilic statins and may therefore increase the risk of intracranial hemorrhage. OBJECTIVE: To determine whether, in older patients following ischemic stroke, receipt of lipophilic statins was associated with differences in the risk of intracranial hemorrhage...
June 15, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28618239/extent-and-risks-of-antipsychotic-off-label-use-in-children-and-adolescents-in-germany-between-2004-and-2011
#16
Carsten Schröder, Michael Dörks, Bianca Kollhorst, Tilo Blenk, Ralf W Dittmann, Edeltraut Garbe, Oliver Riedel
OBJECTIVE: Only little is known about antipsychotic (AP) off-label use (OLU) in pediatric populations. It was the aim of this study to examine the frequency as well as the risks of off-label AP use in underaged patients. METHODS: To calculate the frequency of off-label AP prescriptions for the years 2004-2011, we used claims data of more than two million minors aged 0-17 years. Off-label prescriptions were analyzed with regard to type of OLU, physician specialty, and underlying diagnoses...
June 15, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28615143/monocyte-macrophage-and-t-cell-activation-markers-are-not-independently-associated-with-mi-risk-in-healthy-individuals-results-from-the-hunt-study
#17
Thor Ueland, Lars E Laugsand, Lars J Vatten, Imre Janszky, Carl Platou, Annika E Michelsen, Jan K Damås, Pål Aukrust, Bjørn O Åsvold
BACKGROUND: We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals. METHODS: Serum monocyte/macrophage and T cell activation markers soluble (s) CD163, sCD14, Gal3BP, sCD25 and sCD166 were analyzed by enzyme-immunoassay in a case-control study nested within the population-based HUNT2 cohort in Norway. Among 58,761 apparently healthy men and women followed a median 11...
June 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28613964/early-and-late-onset-preeclampsia-and-the-dna-methylation-of-circadian-clock-and-clock-controlled-genes-in-placental-and-newborn-tissues
#18
C B van den Berg, I Chaves, E M Herzog, S P Willemsen, G T J van der Horst, R P M Steegers-Theunissen
The placenta is important in providing a healthy environment for the fetus and plays a central role in the pathophysiology of preeclampsia (PE). Fetal and placental developments are influenced by epigenetic programming. There is some evidence that PE is controlled to an altered circadian homeostasis. In a nested case-control study embedded in the Rotterdam Periconceptional Cohort, we obtained placental tissue, umbilical cord leukocytes (UCL), and human umbilical venous endothelial cells of 13 early-onset PE, 16 late-onset PE and 83 controls comprising 36 uncomplicated and 47 complicated pregnancies, i...
June 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28604414/dietary-iron-and-heme-iron-consumption-genetic-susceptibility-and-risk-of-crohn-s-disease-and-ulcerative-colitis
#19
Hamed Khalili, Punyanganie S de Silva, Ashwin N Ananthakrishnan, Paul Lochhead, Amit Joshi, John J Garber, James R Richter, Jenny Sauk, Andrew T Chan
BACKGROUND: Dietary iron and heme, likely through their effect on gut commensal bacteria and colonic barrier function, have been shown to modulate colonic inflammation in animal models of colitis. Nonetheless, the link between dietary total and heme iron and risk of Crohn's disease (CD) and ulcerative colitis (UC) has not been previously explored. METHODS: We conducted a prospective cohort study of 165,331 U.S. women enrolled in the Nurses' Health Study and Nurses' Health Study II...
July 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28600048/first-trimester-maternal-serum-analytes-and-second-trimester-uterine-artery-doppler-in-the-prediction-of-preeclampsia-and-fetal-growth-restriction
#20
Ning Yu, Hongyan Cui, Xu Chen, Ying Chang
OBJECTIVE: This study aimed to determine whether pregnancy-associated plasma protein-A (PAPP-A), free β-human chorionic gonadotropin (β-hCG), a disintegrin and metalloprotease 12 (ADAM12), and placenta protein 13 (PP13) in the first trimester, and uterine artery Doppler (UAD) in the second trimester, predict preeclampsia and fetal growth restriction (FGR). MATERIALS AND METHODS: Maternal serum levels of PAPP-A, free β-hCG, ADAM12, and PP13 at 11-13(+6) weeks of gestation and bilateral uterine artery pulsatility index (PI) at 22-24 weeks of gestation were measured in a nested case-control study within a prospective cohort...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
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