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Neuromedicine

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https://www.readbyqxmd.com/read/27695256/future-in-neuromedicine-nanotechnology
#1
Adrija Hajra, Dhrubajyoti Bandyopadhyay, Shyamal Kumar Hajra
No abstract text is available yet for this article.
October 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/27238144/gene-tailored-treatments-for-brain-disorders-challenges-and-opportunities
#2
Giovanni Esposito, Jean Marc Burgunder, John Dunlop, Philip Gorwood, Amir Inamdar, Stefan M Pfister, Roland Pochet, Martin J van den Bent, Nancy Van Hoylandt, Michael Weller, Manfred Westphal, Wolfgang Wick, David Nutt
Brain disorders pose major challenges to medicine and treatment innovation. This is because their spectrum spans inflammatory, degenerative, traumatic/ischaemic, and neoplastic disease processes with a complex and often ill- understood aetiology. An improved genetic and genomic understanding of specific disease pathways offers new approaches to these challenges, but at present it is in its infancy. Here, we review different aspects of the challenges facing neuromedicine, give examples of where there are advances, and highlight challenges to be overcome...
2016: Public Health Genomics
https://www.readbyqxmd.com/read/26931240/acute-kidney-injury-is-more-common-in-acute-haemorrhagic-stroke-in-mymensingh-medical-college-hospital
#3
N C Ray, M A Chowdhury, S R Sarkar
Acute kidney injury (AKI) is a common complication after acute stroke and is an independent predictor of both early and long-term mortality after acute stroke. Acute kidney injury is associated with increased mortality in haemorrhagic stroke patients. This cross sectional observational study was conducted in Nephrology, Neuromedicine and Medicine department of Mymensingh Medical College & Hospital, Mymensingh from July 2012 to June 2014. A total of 240 patients with newly detected acute stroke confirmed by CT scan of brain were included in this study...
January 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/26810426/structure-of-neuroscience-clerkships-in-medical-schools-and-matching-in-neuromedicine
#4
COMMENT
Mark O McCarron
No abstract text is available yet for this article.
January 26, 2016: Neurology
https://www.readbyqxmd.com/read/26810425/structure-of-neuroscience-clerkships-in-medical-schools-and-matching-in-neuromedicine
#5
COMMENT
Nitin K Sethi, Rimas V Lukas, James Brorson, Dara V Albert
No abstract text is available yet for this article.
January 26, 2016: Neurology
https://www.readbyqxmd.com/read/26164834/deferasirox-tat-47-57-peptide-conjugate-as-a-water-soluble-bifunctional-iron-chelator-with-potential-use-in-neuromedicine
#6
Dibakar Goswami, Hector A Vitorino, Roxana Y P Alta, Daniel M Silvestre, Cassiana S Nomura, M Teresa Machini, Breno P EspĆ³sito
Deferasirox (DFX), an orally active and clinically approved iron chelator, is being used extensively for the treatment of iron overload. However, its water insolubility makes it cumbersome for practical use. In addition to this, the low efficacy of DFX to remove brain iron prompted us to synthesize and evaluate a DFX-TAT(47-57) peptide conjugate for its iron chelation properties and permeability across RBE4 cell line, an in vitro model of the blood-brain barrier. The water-soluble conjugate was able to remove labile iron from buffered solution as well as from iron overloaded sera, and the permeability of DFX-TAT(47-57) conjugate into RBE4 cells was not affected compared to parent deferasirox...
October 2015: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/26070342/structure-of-neuroscience-clerkships-in-medical-schools-and-matching-in-neuromedicine
#7
Dara V Albert, Han Yin, Christine Amidei, Karan S Dixit, James R Brorson, Rimas V Lukas
OBJECTIVE: Due to the burden of neurologic disease, there is high demand for neurologists, child neurologists, and neurosurgeons. Only 2.6% of graduating medical students matched in neuromedicine residencies in 2014. This number will not likely meet the needs of the population or the projected shortfall. To compensate for this, the medical education system has an obligation to ensure competence in neuromedicine for all trainees and mentorship for students pursuing training in the field...
July 14, 2015: Neurology
https://www.readbyqxmd.com/read/25879210/induction-of-neurite-outgrowth-in-pc12-cells-treated-with-temperature-controlled-repeated-thermal-stimulation
#8
Tada-aki Kudo, Hiroyasu Kanetaka, Kentaro Mochizuki, Kanako Tominami, Shoko Nunome, Genji Abe, Hiroyuki Kosukegawa, Toshihiko Abe, Hitoshi Mori, Kazumi Mori, Toshiyuki Takagi, Shin-ichi Izumi
To promote the functional restoration of the nervous system following injury, it is necessary to provide optimal extracellular signals that can induce neuronal regenerative activities, particularly neurite formation. This study aimed to examine the regulation of neuritogenesis by temperature-controlled repeated thermal stimulation (TRTS) in rat PC12 pheochromocytoma cells, which can be induced by neurotrophic factors to differentiate into neuron-like cells with elongated neurites. A heating plate was used to apply thermal stimulation, and the correlation of culture medium temperature with varying surface temperature of the heating plate was monitored...
2015: PloS One
https://www.readbyqxmd.com/read/25502465/exosomes-as-a-nanodelivery-system-a-key-to-the-future-of-neuromedicine
#9
REVIEW
Arian Aryani, Bernd Denecke
Since the beginning of the last decade, exosomes have been of increased interest in the science community. Exosomes represent a new kind of long distance transfer of biological molecules among cells. This review provides a comprehensive overview about the construction of exosomes, their targeting and their fusion mechanisms to the recipient cells. Complementarily, the current state of research regarding the cargo of exosomes is discussed. A particular focus was placed on the role of exosomes in the central nervous system...
March 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/25371801/optimization-of-l-tryptophan-biosynthesis-from-l-serine-of-processed-iranian-beet-and-cane-molasses-and-indole-by-induced-escherichia-coli-atcc-11303-cells
#10
Tahereh Sadeghiyan-Rizi, Jamshid Fooladi, Majid Momhed Heravi, Sima Sadrai
BACKGROUND: L-tryptophan is an important ingredient in medicines, especially in neuromedicines such as antidepressants. Many commercial processes employ various microorganisms with high tryptophan synthase activity to produce L-tryptophan from indole and L-serine, but these processes are very costly due to the costs of precursors, especially L-serine. OBJECTIVES: For this reason, we studied the ability to use processed Iranian cane and beet molasses as L-serine sources for L-tryptophan production, which enables us to reach a cost-effective process...
June 2014: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/25174931/colloidal-supramolecular-aggregates-for-therapeutic-application-in-neuromedicine
#11
REVIEW
Donato Cosco, Luisa Di Marzio, Carlotta Marianecci, Elena Trapasso, Donatella Paolino, Christian Celia, Maria Carafa, Massimo Fresta
Neuromedicine has recently been emerging on the research scene and presents interesting challenges in therapeutics. The range of therapies generally used to treat neurological disorders are limited in their efficacy and degree of patient compliance because of the necessity of multiple drug dosages, low drug concentration in the central nervous system and side effects. Moreover, therapeutics require standard drug dosages which cannot be personalized. The limiting obstacle in neuromedicine is still the blood-brain barrier, which prevents the accumulation of endogenous and exogenous compounds inside the brain...
2014: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/25078386/-interdisciplinary-neuromedicine
#12
W Oertel, W Hacke
No abstract text is available yet for this article.
August 2014: Der Nervenarzt
https://www.readbyqxmd.com/read/22529536/healthcare-seeking-behavior-of-patients-with-epileptic-seizure-disorders-attending-a-tertiary-care-hospital-kolkata
#13
Abhik Sinha, Sarmila Mallik, Debasish Sanyal, Prasenjit Sengupta, Samir Dasgupta
INTRODUCTION: Neurological diseases are very important causes of prolonged morbidity and disability, leading to profound financial loss. Epilepsy is one of the most important neurological disorders Healthcare seeking by epilepsy patients is quite diverse and unique. AIMS AND OBJECTIVES: The study was conducted among the epilepsy patients, to assess their healthcare-seeking behavior and its determinants. MATERIALS AND METHODS: Three hundred and fifteen epilepsy patients, selected by systematic random sampling, in the neuromedicine outpatient department of a tertiary care hospital were interviewed with a predesigned, pretested, semi-structured proforma...
January 2012: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/21711249/partnership-and-cooperation-is-necessary-to-improve-and-expand-neurology
#14
N E Gilhus, L J Stovner, L Gjerstad, J M Hoff
BACKGROUND: Brain disorders have a large impact on society, representing one third of the total burden of disease. Neurology is more than before divided into fields of highly specialized branches. OBJECTIVE: To assess the need for co-operation in neuromedicine to achieve optimal results for patient treatment, diagnosis and care. DISCUSSION: Co-operation regarding patients with disorders in the brain and nervous system should involve medical specialists, general practitioners, other professionals, patients and carers...
2011: Acta Neurologica Scandinavica. Supplementum
https://www.readbyqxmd.com/read/20798910/editorial-neurowoche-2010-a-highlight-of-neuromedicine-in-germany
#15
EDITORIAL
R von Kummer
No abstract text is available yet for this article.
August 2010: Clinical Neuroradiology
https://www.readbyqxmd.com/read/20680704/an-introduction-to-sphingolipid-metabolism-and-analysis-by-new-technologies
#16
REVIEW
Yanfeng Chen, Ying Liu, M Cameron Sullards, Alfred H Merrill
Sphingolipids (SP) are a complex class of molecules found in essentially all eukaryotes and some prokaryotes and viruses where they influence membrane structure, intracellular signaling, and interactions with the extracellular environment. Because of the combinatorial nature of their biosynthesis, there are thousands of SP subspecies varying in the lipid backbones and complex phospho- and glycoheadgroups. Therefore, comprehensive or "sphingolipidomic" analyses (structure-specific, quantitative analyses of all SP, or at least all members of a critical subset) are needed to know which and how much of these subspecies are present in a system as a step toward understanding their functions...
December 2010: Neuromolecular Medicine
https://www.readbyqxmd.com/read/20101712/axon-repair-surgical-application-at-a-subcellular-scale
#17
REVIEW
Wesley C Chang, Elizabeth Hawkes, Christopher G Keller, David W Sretavan
Injury to the nervous system is a common occurrence after trauma. Severe cases of injury exact a tremendous personal cost and place a significant healthcare burden on society. Unlike some tissues in the body that exhibit self healing, nerve cells that are injured, particularly those in the brain and spinal cord, are incapable of regenerating circuits by themselves to restore neurological function. In recent years, researchers have begun to explore whether micro/nanoscale tools and materials can be used to address this major challenge in neuromedicine...
March 2010: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/18953144/dysarthric-bengali-speech-a-neurolinguistic-study
#18
N Chakraborty, T Roy, A Hazra, A Biswas, K Bhattacharya
BACKGROUND AND AIMS: Dysarthria affects linguistic domains such as respiration, phonation, articulation, resonance and prosody due to upper motor neuron, lower motor neuron, cerebellar or extrapyramidal tract lesions. Although Bengali is one of the major languages globally, dysarthric Bengali speech has not been subjected to neurolinguistic analysis. We attempted such an analysis with the goal of identifying the speech defects in native Bengali speakers in various types of dysarthria encountered in neurological disorders...
October 2008: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/18626444/epidemiological-study-of-risk-factors-of-stroke-and-its-immediate-consequence
#19
M M Haque, S A Nasreen
The study was a cross sectional study conducted among 48 stroke patients in Medicine & Neuromedicine department of Mymensingh Medical College & Hospital. The objective of the study was to reveal the risk factors and other relevant information & immediate outcome of stroke patients. The sample size was 48 who were selected purposively and study area was selected for easy access. Study period was from 15th May 2007 to 15th July 2007. Forty eight (48) respondents and their reliable attendants were interviewed by pre tested structured questionnaire...
July 2008: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/18583197/the-swan-biomedical-discourse-ontology
#20
Paolo Ciccarese, Elizabeth Wu, Gwen Wong, Marco Ocana, June Kinoshita, Alan Ruttenberg, Tim Clark
Developing cures for highly complex diseases, such as neurodegenerative disorders, requires extensive interdisciplinary collaboration and exchange of biomedical information in context. Our ability to exchange such information across sub-specialties today is limited by the current scientific knowledge ecosystem's inability to properly contextualize and integrate data and discourse in machine-interpretable form. This inherently limits the productivity of research and the progress toward cures for devastating diseases such as Alzheimer's and Parkinson's...
October 2008: Journal of Biomedical Informatics
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