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Vini C Sekhar, Gayathri Viswanathan, Sabulal Baby
Bacopa monnieri, commonly known as Brahmi, has been extensively used as a neuromedicine for various disorders such as anxiety, depression and memory loss. Chemical characterization studies revealed the major active constituents of the herb as the triterpenoid saponins, bacosides. Bacoside A, the vital neuroprotective constituent, is composed of four constituents viz., bacoside A3, bacopaside II, jujubogenin isomer of bacopasaponin C (bacopaside X) and bacopasaponin C. B. monnieri extracts as well as bacosides successfully establish a healthy antioxidant environment in various tissues especially in liver and brain...
April 19, 2018: Current Neuropharmacology
Maitreyee Kar, Chinmaya Kar, Hironmoy Roy, Parmod Goyal
Context: Early clinical exposure (ECE) is one of the important tools to teach basic science to the MBBS students. It is one form of vertical integration between basic science and clinical subjects. This study is an effort at exploring the use of ECE as a motivational tool toward better learning in neuroanatomy for first year MBBS students. Aim: This study aims to make the students interested and motivated to study neuroanatomy by using ECE as learning tool in neuroanatomy and to make the students enable to retain the knowledge of neuroanatomy more efficiently and correlate the knowledge of neuroanatomy with neuromedicine...
December 2017: International Journal of Applied and Basic Medical Research
Michael S Okun, Adolfo Ramirez-Zamora, Kelly D Foote
No abstract text is available yet for this article.
March 1, 2018: JAMA Neurology
Joseph Dumit
What happens when health research is measured by market size? How does this change the dynamics of medical research, and how is its growth envisioned and managed? In this article, I build on my arguments in Drugs for Life: How Pharmaceutical Companies Define our Health, which focused primarily on the development and marketing of mass medications for heart disease and I examine the market dynamics that are used to drive research into and out of psychiatric and other neuromedicines, such as the closing of mental health research at most major pharmaceutical companies...
July 31, 2017: Medical Anthropology
S Azadeh, B P Hobbs, L Ma, D A Nielsen, F G Moeller, V Baladandayuthapani
Advances in neuromedicine have emerged from endeavors to elucidate the distinct genetic factors that influence the changes in brain structure that underlie various neurological conditions. We present a framework for examining the extent to which genetic factors impact imaging phenotypes described by voxel-wise measurements organized into collections of functionally relevant regions of interest (ROIs) that span the entire brain. Statistically, the integration of neuroimaging and genetic data is challenging. Because genetic variants are expected to impact different regions of the brain, an appropriate method of inference must simultaneously account for spatial dependence and model uncertainty...
April 2016: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
Adrija Hajra, Dhrubajyoti Bandyopadhyay, Shyamal Kumar Hajra
No abstract text is available yet for this article.
October 2016: Journal of Neurosciences in Rural Practice
Giovanni Esposito, Jean Marc Burgunder, John Dunlop, Philip Gorwood, Amir Inamdar, Stefan M Pfister, Roland Pochet, Martin J van den Bent, Nancy Van Hoylandt, Michael Weller, Manfred Westphal, Wolfgang Wick, David Nutt
Brain disorders pose major challenges to medicine and treatment innovation. This is because their spectrum spans inflammatory, degenerative, traumatic/ischaemic, and neoplastic disease processes with a complex and often ill- understood aetiology. An improved genetic and genomic understanding of specific disease pathways offers new approaches to these challenges, but at present it is in its infancy. Here, we review different aspects of the challenges facing neuromedicine, give examples of where there are advances, and highlight challenges to be overcome...
2016: Public Health Genomics
N C Ray, M A Chowdhury, S R Sarkar
Acute kidney injury (AKI) is a common complication after acute stroke and is an independent predictor of both early and long-term mortality after acute stroke. Acute kidney injury is associated with increased mortality in haemorrhagic stroke patients. This cross sectional observational study was conducted in Nephrology, Neuromedicine and Medicine department of Mymensingh Medical College & Hospital, Mymensingh from July 2012 to June 2014. A total of 240 patients with newly detected acute stroke confirmed by CT scan of brain were included in this study...
January 2016: Mymensingh Medical Journal: MMJ
Mark O McCarron
No abstract text is available yet for this article.
January 26, 2016: Neurology
Nitin K Sethi, Rimas V Lukas, James Brorson, Dara V Albert
No abstract text is available yet for this article.
January 26, 2016: Neurology
Dibakar Goswami, Hector A Vitorino, Roxana Y P Alta, Daniel M Silvestre, Cassiana S Nomura, M Teresa Machini, Breno P EspĆ³sito
Deferasirox (DFX), an orally active and clinically approved iron chelator, is being used extensively for the treatment of iron overload. However, its water insolubility makes it cumbersome for practical use. In addition to this, the low efficacy of DFX to remove brain iron prompted us to synthesize and evaluate a DFX-TAT(47-57) peptide conjugate for its iron chelation properties and permeability across RBE4 cell line, an in vitro model of the blood-brain barrier. The water-soluble conjugate was able to remove labile iron from buffered solution as well as from iron overloaded sera, and the permeability of DFX-TAT(47-57) conjugate into RBE4 cells was not affected compared to parent deferasirox...
October 2015: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Dara V Albert, Han Yin, Christine Amidei, Karan S Dixit, James R Brorson, Rimas V Lukas
OBJECTIVE: Due to the burden of neurologic disease, there is high demand for neurologists, child neurologists, and neurosurgeons. Only 2.6% of graduating medical students matched in neuromedicine residencies in 2014. This number will not likely meet the needs of the population or the projected shortfall. To compensate for this, the medical education system has an obligation to ensure competence in neuromedicine for all trainees and mentorship for students pursuing training in the field...
July 14, 2015: Neurology
Tada-aki Kudo, Hiroyasu Kanetaka, Kentaro Mochizuki, Kanako Tominami, Shoko Nunome, Genji Abe, Hiroyuki Kosukegawa, Toshihiko Abe, Hitoshi Mori, Kazumi Mori, Toshiyuki Takagi, Shin-ichi Izumi
To promote the functional restoration of the nervous system following injury, it is necessary to provide optimal extracellular signals that can induce neuronal regenerative activities, particularly neurite formation. This study aimed to examine the regulation of neuritogenesis by temperature-controlled repeated thermal stimulation (TRTS) in rat PC12 pheochromocytoma cells, which can be induced by neurotrophic factors to differentiate into neuron-like cells with elongated neurites. A heating plate was used to apply thermal stimulation, and the correlation of culture medium temperature with varying surface temperature of the heating plate was monitored...
2015: PloS One
Arian Aryani, Bernd Denecke
Since the beginning of the last decade, exosomes have been of increased interest in the science community. Exosomes represent a new kind of long distance transfer of biological molecules among cells. This review provides a comprehensive overview about the construction of exosomes, their targeting and their fusion mechanisms to the recipient cells. Complementarily, the current state of research regarding the cargo of exosomes is discussed. A particular focus was placed on the role of exosomes in the central nervous system...
March 2016: Molecular Neurobiology
Tahereh Sadeghiyan-Rizi, Jamshid Fooladi, Majid Momhed Heravi, Sima Sadrai
BACKGROUND: L-tryptophan is an important ingredient in medicines, especially in neuromedicines such as antidepressants. Many commercial processes employ various microorganisms with high tryptophan synthase activity to produce L-tryptophan from indole and L-serine, but these processes are very costly due to the costs of precursors, especially L-serine. OBJECTIVES: For this reason, we studied the ability to use processed Iranian cane and beet molasses as L-serine sources for L-tryptophan production, which enables us to reach a cost-effective process...
June 2014: Jundishapur Journal of Microbiology
Donato Cosco, Luisa Di Marzio, Carlotta Marianecci, Elena Trapasso, Donatella Paolino, Christian Celia, Maria Carafa, Massimo Fresta
Neuromedicine has recently been emerging on the research scene and presents interesting challenges in therapeutics. The range of therapies generally used to treat neurological disorders are limited in their efficacy and degree of patient compliance because of the necessity of multiple drug dosages, low drug concentration in the central nervous system and side effects. Moreover, therapeutics require standard drug dosages which cannot be personalized. The limiting obstacle in neuromedicine is still the blood-brain barrier, which prevents the accumulation of endogenous and exogenous compounds inside the brain...
2014: Current Medicinal Chemistry
W Oertel, W Hacke
No abstract text is available yet for this article.
August 2014: Der Nervenarzt
Abhik Sinha, Sarmila Mallik, Debasish Sanyal, Prasenjit Sengupta, Samir Dasgupta
INTRODUCTION: Neurological diseases are very important causes of prolonged morbidity and disability, leading to profound financial loss. Epilepsy is one of the most important neurological disorders Healthcare seeking by epilepsy patients is quite diverse and unique. AIMS AND OBJECTIVES: The study was conducted among the epilepsy patients, to assess their healthcare-seeking behavior and its determinants. MATERIALS AND METHODS: Three hundred and fifteen epilepsy patients, selected by systematic random sampling, in the neuromedicine outpatient department of a tertiary care hospital were interviewed with a predesigned, pretested, semi-structured proforma...
January 2012: Indian Journal of Community Medicine
N E Gilhus, L J Stovner, L Gjerstad, J M Hoff
BACKGROUND: Brain disorders have a large impact on society, representing one third of the total burden of disease. Neurology is more than before divided into fields of highly specialized branches. OBJECTIVE: To assess the need for co-operation in neuromedicine to achieve optimal results for patient treatment, diagnosis and care. DISCUSSION: Co-operation regarding patients with disorders in the brain and nervous system should involve medical specialists, general practitioners, other professionals, patients and carers...
2011: Acta Neurologica Scandinavica. Supplementum
R von Kummer
No abstract text is available yet for this article.
August 2010: Clinical Neuroradiology
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