keyword
MENU ▼
Read by QxMD icon Read
search

apo B 100

keyword
https://www.readbyqxmd.com/read/28280493/t-cells-specific-for-a-self-peptide-of-apob-100-exacerbate-aortic-atheroma-in-murine-atherosclerosis
#1
Michael K Shaw, Kevin Y Tse, Xiaoqing Zhao, Kathryn Welch, Daniel T Eitzman, Raghavendar R Thipparthi, Paul C Montgomery, Ryan Thummel, Harley Y Tse
On the basis of mouse I-A(b)-binding motifs, two sequences of the murine apolipoprotein B-100 (mApoB-100), mApoB-1003501-3515 (designated P3) and mApoB-100978-992 (designated P6), were found to be immunogenic. In this report, we show that P6 is also atherogenic. Immunization of Apoe(-/-) mice fed a high-fat diet (HFD) with P6 resulted in enhanced development of aortic atheroma as compared to control mice immunized with an irrelevant peptide MOG35-55 or with complete Freund's adjuvant alone. Adoptive transfer of lymph node cells from P6-immunized donor mice to recipients fed an HFD caused exacerbated aortic atheromas, correlating P6-primed cells with disease development...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28274961/lipid-and-lipoprotein-abnormalities-in-acute-lymphoblastic-leukemia-survivors
#2
Sophia Morel, Jade Leahy, Maryse Fournier, Benoit Lamarche, Carole Garofalo, Guy Grimard, Floriane Poulain, Edgard Delvin, Caroline Laverdière, Maja Krajinovic, Simon Drouin, Daniel Sinnett, Valérie Marcil, Emile Levy
Survivors of acute lymphoblastic leukemia (ALL), the most common cancer in children, are at increased risk of developing late cardiometabolic conditions. However, the mechanisms are not fully understood. The study aimed to characterize plasma lipid profile, Apolipoprotein (Apo) distribution and lipoprotein composition of 80 childhood ALL survivors compared to 22 healthy controls. Our results show that, despite their young age, 50% of the ALL survivors displayed dyslipidemia, characterized by increased plasma TG and LDL-cholesterol, as well as decreased HDL-cholesterol...
March 8, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28173800/oxidized-ldl-induced-jab1-influences-nf-%C3%AE%C2%BAb-independent-inflammatory-signaling-in-human-macrophages-during-foam-cell-formation
#3
Anja Schwarz, Gabriel A Bonaterra, Hans Schwarzbach, Ralf Kinscherf
BACKGROUND: Oxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation domain binding protein-1) is present in all stages of human plaques, involved in the Toll-like receptor-mediated activation of p38 mitogen-activated protein kinase (MAPK) and controls nuclear factor-kappa B (NF-κB) activation. Thus, we were interested in the role of JAB1 during foam cell formation of MΦ after oxLDL exposition...
February 7, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28028493/mutation-detection-in-chinese-patients-with-familial-hypercholesterolemia
#4
Ran Du, Liang-Liang Fan, Min-Jie Lin, Zhi-Jian He, Hao Huang, Ya-Qin Chen, Jing-Jing Li, Kun Xia, Shui-Ping Zhao, Rong Xiang
BACKGROUND: Familial hypercholesterolemia (FH) is the first molecularly and clinically characterized genetic disease of lipid metabolism. It is an autosomal dominant disorder with significantly elevated levels of total cholesterol and low density of lipoprotein cholesterol in serum, which would lead to extensive xanthomas and premature coronary heart disease. Mutations in low density lipoprotein receptor (LDLR), proprotein convertase subtilisin/kexin type 9 and Apo lipoprotein B-100 (APOB) have been identified to be the underlying cause of this disease...
2016: SpringerPlus
https://www.readbyqxmd.com/read/28019668/monosialyl-ganglioside-gm3-decreases-apolipoprotein-b-100-secretion-in-liver-cells
#5
Hyunju Choi, Un-Ho Jin, Sung-Koo Kang, Fukushi Abekura, Jun-Young Park, Kyung-Min Kwon, Seok-Jong Suh, Seung-Hak Cho, Ki-Tae Ha, Young-Coon Lee, Tae-Wook Chung, Cheorl-Ho Kim
Some sialic acid-containing glycolipids are known to regulate development of atherosclerosis with accumulated plasma apolipoprotein B-100 (Apo-B)-containing lipoproteins, because Apo-B as an atherogenic apolipoprotein is assembled mainly in VLDL and LDL. Previously, we have elucidated that disialyl GD3 promotes the microsomal triglyceride transfer protein (MTP) gene expression and secretion of triglyceride (TG)-assembled ApoB, claiming the GD3 role in ApoB lipoprotein secretion in liver cells. In the synthetic pathway of gangliosides, GD3 is synthesized by addition of a sialic acid residue to GM3...
December 26, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27956003/lipid-modifying-efficacy-and-tolerability-of-anacetrapib-added-to-ongoing-statin-therapy-in-patients-with-hypercholesterolemia-or-low-high-density-lipoprotein-cholesterol
#6
Christie M Ballantyne, Sukrut Shah, Uma Kher, John A Hunter, Geraldine G Gill, Michael D Cressman, Tanya B Ashraf, Amy O Johnson-Levonas, Yale B Mitchel
To assess the effects of anacetrapib added to statin ± other lipid-modifying therapies in patients with hypercholesterolemia and not at their low-density lipoprotein cholesterol (LDL-C) goal (as per National Cholesterol Education Program Adult Treatment Panel III [NCEP ATP III] guidelines) and in those with low high-density lipoprotein cholesterol (HDL-C). Patients on a stable dose of moderate/high-intensity statin ± other lipid-modifying therapies with LDL-C ≥70, ≥100, ≥130, or ≥160 mg/dl for very high, high, moderate, and low coronary heart disease risk, respectively, or at LDL-C goal with HDL-C ≤40 mg/dl, were randomized 1:1:1, stratified by background therapy use, to anacetrapib 100 mg (n = 153), anacetrapib 25 mg (n = 152), or placebo (n = 154) for 24 weeks, followed by a 12-week off-drug reversal phase...
February 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/27941065/factorial-effects-of-evolocumab-and-atorvastatin-on-lipoprotein-metabolism
#7
Gerald F Watts, Dick C Chan, Ricardo Dent, Ransi Somaratne, Scott M Wasserman, Rob Scott, Sally Burrows, P Hugh R Barrett
BACKGROUND: Monoclonal antibodies against proprotein convertase subtilisin kexin type 9 (PCSK9), such as evolocumab, lower plasma low-density lipoprotein (LDL)-cholesterol concentrations. Evolocumab is under investigation for its effects on cardiovascular outcomes in statin-treated, high-risk patients. The mechanism of action of PCSK9 monoclonal antibodies on lipoprotein metabolism remains to be fully evaluated. Stable isotope tracer kinetics can effectively elucidate the mode of action of new lipid-regulating pharmacotherapies...
January 24, 2017: Circulation
https://www.readbyqxmd.com/read/27935250/apolipoprotein-e-epsilon-genotype-has-a-greater-impact-on-apob-48-than-apob-100-responses-to-dietary-fat-manipulation-insights-from-the-satgen%C3%AE%C2%B5-study
#8
Kim G Jackson, Stacey Lockyer, Andrew L Carvalho-Wells, Christine M Williams, Anne M Minihane, Julie A Lovegrove
SCOPE: To determine the contribution of intestinally and liver-derived lipoproteins to the postprandial plasma triacylglycerol (TAG) response in APOE3/E3 and E3/E4 individuals following chronic dietary fat manipulation. METHODS AND RESULTS: In sequential order, participants (n = 12 E3/E3, n = 11 E3/E4) followed low fat; high-fat, high-saturated fat (HSF); and HSF with 3.45 g/day docosahexaenoic acid (HSF-DHA) diets, each for 8 weeks. After each dietary period, an acute test meal with a macronutrient profile representative of the dietary intervention was consumed...
December 9, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27891330/evaluation-of-lipid-profile-and-apolipoproteins-in-essential-hypertensive-patients
#9
Parsuram Nayak, Suchismita Panda, Pravat Kumar Thatoi, Roma Rattan, Srikrushna Mohapatra, Pramila Kumari Mishra
INTRODUCTION: Essential hypertension is one of the most common diseases of the Indian population contributing greatly to the morbidity, mortality and economic burden. It has a strong association with cardiovascular disease and abnormal lipid metabolism. Not only the traditional lipid parameters, but also the novel lipid components like Apo A1 and Apo B100 also have been identified to play a role. AIM: The present study was done to evaluate serum lipid profile and Apo A1, Apo B 100 in essential hypertensive patients and correlate their values with the degree of hypertension...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27738104/mycobacterium-tuberculosis-malate-synthase-structures-with-fragments-reveal-a-portal-for-substrate-product-exchange
#10
Hsiao-Ling Huang, Inna V Krieger, Maloy K Parai, Vijay B Gawandi, James C Sacchettini
Fragment screening and high throughput screening are complementary approaches that combine with structural biology to explore the binding capabilities of an active site. We have used a fragment-based approach on malate synthase (GlcB) from Mycobacterium tuberculosis and discovered several novel binding chemotypes. In addition, the crystal structures of GlcB in complex with these fragments indicated conformational changes in the active site that represent the enzyme conformations during catalysis. Additional structures of the complex with malate and of the apo form of GlcB supported that hypothesis...
December 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27665230/antisense-oligonucleotides-targeting-apolipoprotein-a-in-people-with-raised-lipoprotein-a-two-randomised-double-blind-placebo-controlled-dose-ranging-trials
#11
Nicholas J Viney, Julian C van Capelleveen, Richard S Geary, Shuting Xia, Joseph A Tami, Rosie Z Yu, Santica M Marcovina, Steven G Hughes, Mark J Graham, Rosanne M Crooke, Stanley T Crooke, Joseph L Witztum, Erik S Stroes, Sotirios Tsimikas
BACKGROUND: Elevated lipoprotein(a) (Lp[a]) is a highly prevalent (around 20% of people) genetic risk factor for cardiovascular disease and calcific aortic valve stenosis, but no approved specific therapy exists to substantially lower Lp(a) concentrations. We aimed to assess the efficacy, safety, and tolerability of two unique antisense oligonucleotides designed to lower Lp(a) concentrations. METHODS: We did two randomised, double-blind, placebo-controlled trials...
November 5, 2016: Lancet
https://www.readbyqxmd.com/read/27455558/-the-excess-of-palmitic-fatty-acid-in-food-as-main-cause-of-lipoidosis-of-insulin-dependent-cells-skeletal-myocytes-cardio-myocytes-periportal-hepatocytes-kupffer-macrophages-and-b-cells-of-pancreas
#12
REVIEW
V N Titov
In phylogenesis, becoming of biologicalfunctions and biological reactions proceeds with the purpose ofpermanent increasing of "kinetic perfection ". The main role belongs to factors ofphysical, chemical and biological kinetics, their evaluation using systemic approach technique under permanent effect of natural selection. The late-in-phylogenesis insulin, proceeded with, in development of biological function of locomotion, specialization of insulin-dependent cells: skeletal myocytes, syncytium of cardiomyocytes, subcutaneous adipocytes, periportal hepatocytes, Kupffer's macrophages and β-cells of islets of pancreas...
February 2016: Klinicheskaia Laboratornaia Diagnostika
https://www.readbyqxmd.com/read/27427488/omega-3-polyunsaturated-fatty-acid-profiles-and-relationship-with-cardiometabolic-risk-factors-in-cree-eeyouch-of-northern-qu%C3%A3-bec
#13
Françoise Proust, Olivia Drescher, Elhadji A Laouan-Sidi, Elizabeth Robinson, Michel Lucas, Éric Dewailly
BACKGROUND: n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) from fish are known modulators of cardiometabolic risk factors. OBJECTIVE: To examine fatty acids (FAs) status and the relationship between n-3 LC-PUFA and cardiometabolic risk factors in Cree participants. DESIGN: We analyzed data from a cross-sectional study (n=829) conducted in Cree adults (aged 18-74 years) from 7 communities of the James Bay territory of Quebec (Canada) in 2005-2009...
2016: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/27422746/the-blood-lipid-regulation-of-monascus-produced-monascin-and-ankaflavin-via-the-suppression-of-low-density-lipoprotein-cholesterol-assembly-and-stimulation-of-apolipoprotein-a1-expression-in-the-liver
#14
Chun-Lin Lee, Ja-Yan Wen, Ya-Wen Hsu, Tzu-Ming Pan
BACKGROUND/PURPOSES: Monascin (MS) and ankaflavin (AK) produced by Monascus purpureus NTU 568 were proven to show excellent hypolipidemic effects in our previous studies; however, the mechanism is still unclear. METHODS: This study used MS, AK, and monacolin K as test substances and performed tests on rats fed high-fat and high-cholesterol diet for 8 weeks. The lipid levels and the related protein levels of the rats were assessed to understand the effects of MS, AK, and monacolin K on lipid metabolism...
June 24, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/27411815/association-between-small-dense-ldl-and-sub-clinical-atherosclerosis-in-patients-with-psoriatic-arthritis
#15
Marco Gentile, Rosario Peluso, Matteo Nicola Dario Di Minno, Luisa Costa, Francesco Caso, Biagio de Simone, Gabriella Iannuzzo, Raffaele Scarpa, Paolo Rubba
Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder occurring in patients with psoriasis. Several studies have shown an association between Psa and traditional atherosclerotic risk factors. We evaluated the relationship between small dense low-density lipoproteins particles (sd-LDL) a risk marker for atherosclerosis, sub-clinical atherosclerosis and PsA in a group of 50 patients with PsA and in 100 controls. Cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), triglycerides, insulin, homeostasis model assessment (HOMA), Apo B, and sd-LDL have been measured...
August 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27388615/effect-of-losartan-and-spironolactone-on-triglyceride-rich-lipoproteins-in-diabetic-nephropathy
#16
Anand Srivastava, Beverley Adams-Huet, Gloria L Vega, Robert D Toto
UNLABELLED: Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) can improve dyslipidemia in patients with diabetes and albuminuria. Whether combined ACEi+ARB or ACEi+mineralocorticoid receptor blockade improves dyslipidemia is not known. We hypothesized long-term administration of either losartan 100 mg or spironolactone 25 mg once daily added onto lisinopril 80 mg once daily would improve dyslipidemia in diabetic nephropathy (DN). We measured lipid levels, very-low-density (V), intermediate-density (I), low-density (LDL), high-density (HDL) lipoprotein, LDL particle size with their respective cholesterol (C) and apolipoprotein B levels (ApoB), and urine albumin/creatinine ratio (UACR) at 12-week interval during a 48-week randomized, double-blind placebo-controlled trial in 81 patients with DN...
August 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27248482/anti-sense-oligonucleotide-therapies-for-the-treatment-of-hyperlipidaemia
#17
Anthony S Wierzbicki, Adie Viljoen
INTRODUCTION: Anti-sense oligonucleotide (ASO) therapies are a new development in clinical pharmacology offering greater specificity compared to small molecule inhibitors and the ability to target intracellular process' not susceptible to antibody-based therapies. AREAS COVERED: This article reviews the chemical biology of ASOs and related RNA therapeutics. It then reviews the data on their use to treat hyperlipidaemia. Data on mipomersen - an ASO to apolipoprotein B-100(apoB) licensed for treatment of homozygous familial hypercholesterolaemia (FH) is presented...
September 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27183722/-the-etiology-and-pathogenesis-of-successive-making-test-on-hypertriglyceridemia-hypercholesterolemiia-and-hypoglycemia-the-common-character-of-etiologic-factors-of-metabolic-pandemic-and-compensatory-role-of-apoc-111
#18
V N Titov
The concepts of atherosclerosis as afatly acids pathology, deficiency syndrome in cells ofpolyene fatty acids were expounded in 1990. The spirits cholesterol and glycerin play integrated physical chemical function in fatly acids' metabolism in transforming polar fatty acids into such non-polar form as ethers cholesterol and triglycerides. The amount of fatty acids transferred by lipoproteins to triglycerides significantly exceeds amount of fatty acids as ethers cholesterol. The triglycerides dominate in cells and ethers cholesterol outside cells...
January 2016: Klinicheskaia Laboratornaia Diagnostika
https://www.readbyqxmd.com/read/27174546/analysis-of-low-density-lipoprotein-associated-proteins-using-the-method-of-digitized-native-protein-mapping
#19
Ya Jin, Jin Chen, Ahui Wang, Jun Zhang, Shumin Chen, Takashi Manabe, Wen Tan
The method of digitized native protein mapping, combining nondenaturing micro 2DE, grid gel-cutting, and quantitative LC-MS/MS (in data-independent acquisition mode, or MS(E) ), was improved by using a new MS/MS mode, ion mobility separation enhanced-MS(E) (HDMS(E) ), and applied to analyze the area of human plasma low-density lipoprotein (LDL). An 18 mm × 4.8 mm rectangular area which included LDL on a nondenaturing micro 2D gel of human plasma was grid-cut into 72 square gel pieces and subjected to quantitative LC-MS/MS...
July 2016: Electrophoresis
https://www.readbyqxmd.com/read/27155339/a-study-of-serum-apo-a-1-and-apo-b-100-levels-in-women-with-preeclampsia
#20
Hakan Timur, Halil Korkut Daglar, Ozgur Kara, Ayse Kirbas, Hasan Ali Inal, Gulenay Gencosmanoglu Turkmen, Zehra Yilmaz, Burak Elmas, Dilek Uygur
OBJECTIVE: To investigate Apo A-1 and Apo B-100 levels and Apo B-100/Apo A-1 ratios in preeclamptic (PE) patients. MATERIALS AND METHODS: Forty-eight PE and 48 without PE patients (healthy pregnancies) matched for gestational age were included. Maternal age, parity, gestational age at delivery, obstetrical complications including intrauterine growth restriction (IUGR) and gestational diabetes mellitus (GDM), serum Apo A-1 and Apo B-100 levels, and the Apo B-100/Apo A-1 ratio were compared...
April 2016: Pregnancy Hypertension
keyword
keyword
78593
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"