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https://www.readbyqxmd.com/read/28028493/mutation-detection-in-chinese-patients-with-familial-hypercholesterolemia
#1
Ran Du, Liang-Liang Fan, Min-Jie Lin, Zhi-Jian He, Hao Huang, Ya-Qin Chen, Jing-Jing Li, Kun Xia, Shui-Ping Zhao, Rong Xiang
BACKGROUND: Familial hypercholesterolemia (FH) is the first molecularly and clinically characterized genetic disease of lipid metabolism. It is an autosomal dominant disorder with significantly elevated levels of total cholesterol and low density of lipoprotein cholesterol in serum, which would lead to extensive xanthomas and premature coronary heart disease. Mutations in low density lipoprotein receptor (LDLR), proprotein convertase subtilisin/kexin type 9 and Apo lipoprotein B-100 (APOB) have been identified to be the underlying cause of this disease...
2016: SpringerPlus
https://www.readbyqxmd.com/read/28019668/monosialyl-ganglioside-gm3-decreases-apolipoprotein-b-100-secretion-in-liver-cells
#2
Hyunju Choi, Un-Ho Jin, Sung-Koo Kang, Fukushi Abekura, Jun-Young Park, Kyung-Min Kwon, Seok-Jong Suh, Seung-Hak Cho, Ki-Tae Ha, Young-Coon Lee, Tae-Wook Chung, Cheorl-Ho Kim
Some sialic acid-containing glycolipids are known to regulate development of atherosclerosis with accumulated plasma apolipoprotein B-100 (Apo-B)-containing lipoproteins, because Apo-B as an atherogenic apolipoprotein is assembled mainly in VLDL and LDL. Previously, we have elucidated that disialyl GD3 promotes the microsomal triglyceride transfer protein (MTP) gene expression and secretion of triglyceride (TG)-assembled ApoB, claiming the GD3 role in ApoB lipoprotein secretion in liver cells. In the synthetic pathway of gangliosides, GD3 is synthesized by addition of a sialic acid residue to GM3...
December 26, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27956003/lipid-modifying-efficacy-and-tolerability-of-anacetrapib-added-to-ongoing-statin-therapy-in-patients-with-hypercholesterolemia-or-low-high-density-lipoprotein-cholesterol
#3
Christie M Ballantyne, Sukrut Shah, Uma Kher, John A Hunter, Geraldine G Gill, Michael D Cressman, Tanya B Ashraf, Amy O Johnson-Levonas, Yale B Mitchel
To assess the effects of anacetrapib added to statin ± other lipid-modifying therapies in patients with hypercholesterolemia and not at their low-density lipoprotein cholesterol (LDL-C) goal (as per National Cholesterol Education Program Adult Treatment Panel III [NCEP ATP III] guidelines) and in those with low high-density lipoprotein cholesterol (HDL-C). Patients on a stable dose of moderate/high-intensity statin ± other lipid-modifying therapies with LDL-C ≥70, ≥100, ≥130, or ≥160 mg/dl for very high, high, moderate, and low coronary heart disease risk, respectively, or at LDL-C goal with HDL-C ≤40 mg/dl, were randomized 1:1:1, stratified by background therapy use, to anacetrapib 100 mg (n = 153), anacetrapib 25 mg (n = 152), or placebo (n = 154) for 24 weeks, followed by a 12-week off-drug reversal phase...
February 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/27941065/factorial-effects-of-evolocumab-and-atorvastatin-on-lipoprotein-metabolism
#4
Gerald F Watts, Dick C Chan, Ricardo E Dent, Ransi Somaratne, Scott M Wasserman, Rob Scott, Sally Burrows, Peter Hugh R Barrett
BACKGROUND: -Monoclonal antibodies (mAbs) against proprotein convertase subtilisin kexin type 9 (PCSK9), such as evolocumab, lower plasma low-density lipoprotein (LDL)-cholesterol concentrations. Evolocumab is under investigation for its effects on cardiovascular outcomes in statin-treated, high-risk patients. The mechanism of action of PCSK9 mAbs on lipoprotein metabolism remains to be fully evaluated. Stable isotope tracer kinetics can effectively elucidate the mode of action of new lipid regulating pharmacotherapies...
December 9, 2016: Circulation
https://www.readbyqxmd.com/read/27935250/apolipoprotein-e-epsilon-genotype-has-a-greater-impact-on-apob-48-than-apob-100-responses-to-dietary-fat-manipulation-insights-from-the-satgen%C3%AE%C2%B5-study
#5
Kim G Jackson, Stacey Lockyer, Andrew L Carvalho-Wells, Christine M Williams, Anne M Minihane, Julie A Lovegrove
SCOPE: To determine the contribution of intestinally and liver-derived lipoproteins to the postprandial plasma triacylglycerol (TAG) response in APOE3/E3 and E3/E4 individuals following chronic dietary fat manipulation. METHODS AND RESULTS: In sequential order, participants (n = 12 E3/E3, n = 11 E3/E4) followed low fat (LF); high-fat, high-saturated fat (HSF); and HSF with 3.45 g/day docosahexaenoic acid (HSF-DHA) diets, each for 8 weeks. After each dietary period, an acute test meal with a macronutrient profile representative of the dietary intervention was consumed...
December 9, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27891330/evaluation-of-lipid-profile-and-apolipoproteins-in-essential-hypertensive-patients
#6
Parsuram Nayak, Suchismita Panda, Pravat Kumar Thatoi, Roma Rattan, Srikrushna Mohapatra, Pramila Kumari Mishra
INTRODUCTION: Essential hypertension is one of the most common diseases of the Indian population contributing greatly to the morbidity, mortality and economic burden. It has a strong association with cardiovascular disease and abnormal lipid metabolism. Not only the traditional lipid parameters, but also the novel lipid components like Apo A1 and Apo B100 also have been identified to play a role. AIM: The present study was done to evaluate serum lipid profile and Apo A1, Apo B 100 in essential hypertensive patients and correlate their values with the degree of hypertension...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27738104/mycobacterium-tuberculosis-malate-synthase-structures-with-fragments-reveal-a-portal-for-substrate-product-exchange
#7
Hsiao-Ling Huang, Inna V Krieger, Maloy K Parai, Vijay B Gawandi, James C Sacchettini
Fragment screening and high throughput screening are complementary approaches that combine with structural biology to explore the binding capabilities of an active site. We have used a fragment-based approach on malate synthase (GlcB) from Mycobacterium tuberculosis and discovered several novel binding chemotypes. In addition, the crystal structures of GlcB in complex with these fragments indicated conformational changes in the active site that represent the enzyme conformations during catalysis. Additional structures of the complex with malate and of the apo form of GlcB supported that hypothesis...
December 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27665230/antisense-oligonucleotides-targeting-apolipoprotein-a-in-people-with-raised-lipoprotein-a-two-randomised-double-blind-placebo-controlled-dose-ranging-trials
#8
Nicholas J Viney, Julian C van Capelleveen, Richard S Geary, Shuting Xia, Joseph A Tami, Rosie Z Yu, Santica M Marcovina, Steven G Hughes, Mark J Graham, Rosanne M Crooke, Stanley T Crooke, Joseph L Witztum, Erik S Stroes, Sotirios Tsimikas
BACKGROUND: Elevated lipoprotein(a) (Lp[a]) is a highly prevalent (around 20% of people) genetic risk factor for cardiovascular disease and calcific aortic valve stenosis, but no approved specific therapy exists to substantially lower Lp(a) concentrations. We aimed to assess the efficacy, safety, and tolerability of two unique antisense oligonucleotides designed to lower Lp(a) concentrations. METHODS: We did two randomised, double-blind, placebo-controlled trials...
November 5, 2016: Lancet
https://www.readbyqxmd.com/read/27455558/-the-excess-of-palmitic-fatty-acid-in-food-as-main-cause-of-lipoidosis-of-insulin-dependent-cells-skeletal-myocytes-cardio-myocytes-periportal-hepatocytes-kupffer-macrophages-and-b-cells-of-pancreas
#9
REVIEW
V N Titov
In phylogenesis, becoming of biologicalfunctions and biological reactions proceeds with the purpose ofpermanent increasing of "kinetic perfection ". The main role belongs to factors ofphysical, chemical and biological kinetics, their evaluation using systemic approach technique under permanent effect of natural selection. The late-in-phylogenesis insulin, proceeded with, in development of biological function of locomotion, specialization of insulin-dependent cells: skeletal myocytes, syncytium of cardiomyocytes, subcutaneous adipocytes, periportal hepatocytes, Kupffer's macrophages and β-cells of islets of pancreas...
February 2016: Klinicheskaia Laboratornaia Diagnostika
https://www.readbyqxmd.com/read/27427488/omega-3-polyunsaturated-fatty-acid-profiles-and-relationship-with-cardiometabolic-risk-factors-in-cree-eeyouch-of-northern-qu%C3%A3-bec
#10
Françoise Proust, Olivia Drescher, Elhadji A Laouan-Sidi, Elizabeth Robinson, Michel Lucas, Éric Dewailly
BACKGROUND: n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) from fish are known modulators of cardiometabolic risk factors. OBJECTIVE: To examine fatty acids (FAs) status and the relationship between n-3 LC-PUFA and cardiometabolic risk factors in Cree participants. DESIGN: We analyzed data from a cross-sectional study (n=829) conducted in Cree adults (aged 18-74 years) from 7 communities of the James Bay territory of Quebec (Canada) in 2005-2009...
2016: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/27422746/the-blood-lipid-regulation-of-monascus-produced-monascin-and-ankaflavin-via-the-suppression-of-low-density-lipoprotein-cholesterol-assembly-and-stimulation-of-apolipoprotein-a1-expression-in-the-liver
#11
Chun-Lin Lee, Ja-Yan Wen, Ya-Wen Hsu, Tzu-Ming Pan
BACKGROUND/PURPOSES: Monascin (MS) and ankaflavin (AK) produced by Monascus purpureus NTU 568 were proven to show excellent hypolipidemic effects in our previous studies; however, the mechanism is still unclear. METHODS: This study used MS, AK, and monacolin K as test substances and performed tests on rats fed high-fat and high-cholesterol diet for 8 weeks. The lipid levels and the related protein levels of the rats were assessed to understand the effects of MS, AK, and monacolin K on lipid metabolism...
June 24, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/27411815/association-between-small-dense-ldl-and-sub-clinical-atherosclerosis-in-patients-with-psoriatic-arthritis
#12
Marco Gentile, Rosario Peluso, Matteo Nicola Dario Di Minno, Luisa Costa, Francesco Caso, Biagio de Simone, Gabriella Iannuzzo, Raffaele Scarpa, Paolo Rubba
Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder occurring in patients with psoriasis. Several studies have shown an association between Psa and traditional atherosclerotic risk factors. We evaluated the relationship between small dense low-density lipoproteins particles (sd-LDL) a risk marker for atherosclerosis, sub-clinical atherosclerosis and PsA in a group of 50 patients with PsA and in 100 controls. Cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), triglycerides, insulin, homeostasis model assessment (HOMA), Apo B, and sd-LDL have been measured...
August 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27388615/effect-of-losartan-and-spironolactone-on-triglyceride-rich-lipoproteins-in-diabetic-nephropathy
#13
Anand Srivastava, Beverley Adams-Huet, Gloria L Vega, Robert D Toto
UNLABELLED: Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) can improve dyslipidemia in patients with diabetes and albuminuria. Whether combined ACEi+ARB or ACEi+mineralocorticoid receptor blockade improves dyslipidemia is not known. We hypothesized long-term administration of either losartan 100 mg or spironolactone 25 mg once daily added onto lisinopril 80 mg once daily would improve dyslipidemia in diabetic nephropathy (DN). We measured lipid levels, very-low-density (V), intermediate-density (I), low-density (LDL), high-density (HDL) lipoprotein, LDL particle size with their respective cholesterol (C) and apolipoprotein B levels (ApoB), and urine albumin/creatinine ratio (UACR) at 12-week interval during a 48-week randomized, double-blind placebo-controlled trial in 81 patients with DN...
August 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27248482/anti-sense-oligonucleotide-therapies-for-the-treatment-of-hyperlipidaemia
#14
Anthony S Wierzbicki, Adie Viljoen
INTRODUCTION: Anti-sense oligonucleotide (ASO) therapies are a new development in clinical pharmacology offering greater specificity compared to small molecule inhibitors and the ability to target intracellular process' not susceptible to antibody-based therapies. AREAS COVERED: This article reviews the chemical biology of ASOs and related RNA therapeutics. It then reviews the data on their use to treat hyperlipidaemia. Data on mipomersen - an ASO to apolipoprotein B-100(apoB) licensed for treatment of homozygous familial hypercholesterolaemia (FH) is presented...
September 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27183722/-the-etiology-and-pathogenesis-of-successive-making-test-on-hypertriglyceridemia-hypercholesterolemiia-and-hypoglycemia-the-common-character-of-etiologic-factors-of-metabolic-pandemic-and-compensatory-role-of-apoc-111
#15
V N Titov
The concepts of atherosclerosis as afatly acids pathology, deficiency syndrome in cells ofpolyene fatty acids were expounded in 1990. The spirits cholesterol and glycerin play integrated physical chemical function in fatly acids' metabolism in transforming polar fatty acids into such non-polar form as ethers cholesterol and triglycerides. The amount of fatty acids transferred by lipoproteins to triglycerides significantly exceeds amount of fatty acids as ethers cholesterol. The triglycerides dominate in cells and ethers cholesterol outside cells...
January 2016: Klinicheskaia Laboratornaia Diagnostika
https://www.readbyqxmd.com/read/27174546/analysis-of-low-density-lipoprotein-associated-proteins-using-the-method-of-digitized-native-protein-mapping
#16
Ya Jin, Jin Chen, Ahui Wang, Jun Zhang, Shumin Chen, Takashi Manabe, Wen Tan
The method of digitized native protein mapping, combining nondenaturing micro 2DE, grid gel-cutting, and quantitative LC-MS/MS (in data-independent acquisition mode, or MS(E) ), was improved by using a new MS/MS mode, ion mobility separation enhanced-MS(E) (HDMS(E) ), and applied to analyze the area of human plasma low-density lipoprotein (LDL). An 18 mm × 4.8 mm rectangular area which included LDL on a nondenaturing micro 2D gel of human plasma was grid-cut into 72 square gel pieces and subjected to quantitative LC-MS/MS...
July 2016: Electrophoresis
https://www.readbyqxmd.com/read/27155339/a-study-of-serum-apo-a-1-and-apo-b-100-levels-in-women-with-preeclampsia
#17
Hakan Timur, Halil Korkut Daglar, Ozgur Kara, Ayse Kirbas, Hasan Ali Inal, Gulenay Gencosmanoglu Turkmen, Zehra Yilmaz, Burak Elmas, Dilek Uygur
OBJECTIVE: To investigate Apo A-1 and Apo B-100 levels and Apo B-100/Apo A-1 ratios in preeclamptic (PE) patients. MATERIALS AND METHODS: Forty-eight PE and 48 without PE patients (healthy pregnancies) matched for gestational age were included. Maternal age, parity, gestational age at delivery, obstetrical complications including intrauterine growth restriction (IUGR) and gestational diabetes mellitus (GDM), serum Apo A-1 and Apo B-100 levels, and the Apo B-100/Apo A-1 ratio were compared...
April 2016: Pregnancy Hypertension
https://www.readbyqxmd.com/read/27099252/lipid-biomarkers-and-long-term-risk-of-cancer-in-the-women-s-health-study
#18
Paulette D Chandler, Yiqing Song, Jennifer Lin, Shumin Zhang, Howard D Sesso, Samia Mora, Edward L Giovannucci, Kathryn E Rexrode, M Vinayaga Moorthy, Chunying Li, Paul M Ridker, I-Min Lee, JoAnn E Manson, Julie E Buring, Lu Wang
BACKGROUND: Lipid biomarkers, such as HDL-cholesterol concentrations, have been shown to have positive, inverse, and null associations with total, breast, and colorectal cancer risks. Studies of novel lipid biomarkers, such as apolipoprotein A-I (apo A-I) and apolipoprotein B-100 (apo B-100), and cancer risk have been sparse, to our knowledge. OBJECTIVES: We evaluated the prospective association of total, breast, colorectal, and lung cancers and cancer mortality with circulating lipid biomarkers in 15,602 female health professionals in the Women's Health Study (aged ≥45 y, free of cardiovascular disease and cancer, and without hormone replacement therapy or lipid-lowering medications at baseline)...
June 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27062408/effects-of-k-877-a-novel-selective-ppar%C3%AE-modulator-spparm%C3%AE-in-dyslipidaemic-patients-a-randomized-double-blind-active-and-placebo-controlled-phase-2-trial
#19
Shun Ishibashi, Shizuya Yamashita, Hidenori Arai, Eiichi Araki, Koutaro Yokote, Hideki Suganami, Jean-Charles Fruchart, Tatsuhiko Kodama
BACKGROUND AND AIMS: To assess the efficacy and safety of K-877 (Pemafibrate), a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα) that possesses unique PPARα activity and selectivity, compared with placebo and fenofibrate in dyslipidaemic patients with high triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) levels. METHODS AND RESULTS: This study was a double blind, placebo-controlled, parallel-group 12-week clinical trial...
June 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27034958/n-3-polyunsaturated-fatty-acid-supplementation-has-no-effect-on-postprandial-triglyceride-rich-lipoprotein-kinetics-in-men-with-type-2-diabetes
#20
RANDOMIZED CONTROLLED TRIAL
André J Tremblay, Benoît Lamarche, Jean-Charles Hogue, Patrick Couture
Dietary n-3 polyunsaturated fatty acids (PUFAs) have been proposed to modulate plasma lipids, lipoprotein metabolism, and inflammatory state and to reduce triglyceride (TG) concentrations. The present double-blind, randomized, placebo-controlled, crossover study investigated the effects of n-3 PUFA supplementation at 3 g/d for 8 weeks on the intravascular kinetics of intestinally derived apolipoprotein (apo) B-48-containing lipoproteins in 10 men with type 2 diabetes. In vivo kinetics of the TG-rich lipoprotein (TRL) apoB-48 and VLDL apoB-100 were assessed using a primed-constant infusion of L-[5,5,5-D3] leucine for 12 hours in a fed state...
2016: Journal of Diabetes Research
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