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Mitochondrion AND Pioglitazone

Yi Ding, Huaqiang Fang, Wei Shang, Yao Xiao, Tao Sun, Ning Hou, Lin Pan, Xueting Sun, Qi Ma, Jingsong Zhou, Xianhua Wang, Xiuqin Zhang, Heping Cheng
UNLABELLED: Central to bioenergetics and reactive oxygen species (ROS) signaling, the mitochondrion plays pivotal roles in the pathogenesis of metabolic diseases. Recent advances have shown that mitochondrial flash ("mitoflash") visualized by the biosensor mt-cpYFP affords a frequency-coded, optical readout linked to mitochondrial ROS production and energy metabolism, at the resolution of a single mitochondrion. To investigate possible mitoflash responses to metabolic stress in insulin resistance (IR), we generated an mt-cpYFP-expressing db/db mouse model with the obesity and IR phenotypes unaltered...
October 2015: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Yao Li, Xinxia Zhang, Nanwei Tong
This study aimed to investigate the effect of pioglitazone (PIO) on insulin secretion and mitochondrial ultrastructure and function in 3 cells. HIT-T15 cells were treated with control or palmitate (free fat acids, FFA) or/and PIO and divided into 7 groups: Control group; 0.5 mmol/l FFA (LF); 0.5 mmol/l FFA plus 10-7 mol/I PIO (LFLP); 0.5 mmol/l FFA plus 10-5mol/I PIO (LFHP); 1.0 mmol/l FFA (HF); 1.0 mmol/l FFA plus 10-7mol/I PIO (HFLP); 1.0 mmol/l FFA plus 10-5 mol/I PIO (HFHP). Apoptotic peaks, mitochondrial ultrastructure, ATP/ADP, mRNA levels of peroxisome proliferater activated receptor gamma coactivator-1 (PGC-1) and nucleus respiratory factor-1 (NRF-1) as well as insulin secretion were measured...
April 2013: Die Pharmazie
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