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https://www.readbyqxmd.com/read/29679313/effects-of-different-natural-extracts-in-an-experimental-model-of-benign-prostatic-hyperplasia-bph
#1
Irene Paterniti, Michela Campolo, Marika Cordaro, Rosalba Siracusa, Antonio Filippone, Emanuela Esposito, Salvatore Cuzzocrea
OBJECTIVE AND DESIGN: To characterize the impact of inflammatory process and oxidative stress in the degree of benign prostatic hyperplasia (BPH), a common condition in which chronic inflammation plays a crucial role, we investigated the effect of different plant extract preparations in an in vivo model of BPH as new therapeutic target. MATERIAL: BPH was made in rats with daily administration of testosterone propionate (3 mg/kg) for 14 days. TREATMENT: Rats were randomized into different groups to receive oral administration of plant extract preparations: Serenoa repens with selenium (SeR 28...
April 20, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29677872/re-testosterone-therapy-for-sexual-dysfunction-in-men-with-type-2-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
https://www.readbyqxmd.com/read/29675480/pituitary-dysfunction-from-an-unruptured-ophthalmic-internal-carotid-artery-aneurysm-with-improved-2-year-follow-up-results-a-case-report
#3
Meng Qi, Ming Ye, Meng Li, Peng Zhang
Internal carotid artery (ICA) supraclinoid segment aneurysms extending into the sellar region and leading to pituitary dysfunction are a rare occurrence. To date, long-term follow up of pituitary function 2 years post-treatment has never been reported. Herein, we present a case of pituitary dysfunction due to an unruptured ophthalmic segment internal carotid artery aneurysm and report improved 2-year follow-up results. A 76-year-old male presented with disturbed consciousness due to hyponatremia, which was caused by hypoadrenocorticism resulting from pituitary dysfunction complicated by hypogonadism and hypothyroidism...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29674209/possible-mechanisms-underlying-fatty-liver-in-a-rat-model-of-male-hypogonadism-a-protective-role-for-testosterone
#4
Hussein F Sakr, Abdelaziz M Hussein, Elsayed A Eid, Mahmoud AlKhateeb
AIMS: To investigate the effects of testosterone (Test) deficiency and testosterone replacement therapy (TRT) on the development of non-alcoholic fatty liver disease (NAFLD) and associated peripheral insulin resistance (IR) in male rats and to illustrate the underlying mechanisms of action. MATERIALS AND METHODS: male Sprague Dawley rats were divided into 3 groups as follows: 1) sham-operated group (n=11), 2) ORCD-induced group (n=9) exposed to orchidectomy (ORCD), achieved by complete surgical removal of testicles, and 3) ORCD+ Test treated group (n=10) (11 ng/ mL Test propionate, 3x/week, S...
April 16, 2018: Steroids
https://www.readbyqxmd.com/read/29667546/seminal-supar-levels-as-marker-of-abacterial-male-accessory-gland-inflammation-in-hypogonadism
#5
Domenico Milardi, Giuseppe Grande, Chiara Autilio, Francesca Mancini, Laura De Marinis, Riccardo Marana, Cecilia Zuppi, Andrea Urbani, Alfredo Pontecorvi, Silvia Baroni
Recent evidences suggest that hypogonadism is an important risk factor for lower urinary tract symptoms and benign prostatic hyperplasia. Several papers have discussed the role of chronic inflammation in the development of BPH, which may be modulated by the hypogonadal state. Soluble urokinase-type plasminogen activator receptor (suPAR), known protein marker of systemic inflammation, can be assayed in the seminal plasma and represents a reliable and sensitive marker of inflammation for the male accessory gland inflammation (MAGI)...
April 18, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29666838/a-brief-history-of-intracrine-androgen-metabolism-by-castration-recurrent-prostate-cancer
#6
REVIEW
James L Mohler
This mini-review describes the evolution of the concept of intracrine androgen metabolism by prostate cancer during androgen deprivation therapy. Persistence of androgen receptor protein in the face of castrate circulating levels of testosterone could not be explained fully by hypersensitization or mutation of the androgen receptor. The hypothesis that castration-recurrent prostate cancer produced its own testosterone was proven using radioimmunoassay and mass spectrometry methods adopted for use in prostate tissue...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666834/androgen-action-in-prostate-function-and-disease
#7
REVIEW
Partha P Banerjee, Subhadra Banerjee, Terry R Brown, Barry R Zirkin
Benign prostatic hyperplasia (BPH) is an enlargement of the prostate gland that is frequently found in aging men. Androgens are essential for the development and differentiated function of the prostate, as well as for proliferation and survival of prostatic cells. In man, dog and rodent, there are age-related decreases in serum testosterone. Despite the lower serum testosterone levels, benign prostatic hyperplasia increases with age in men and dogs, while age-dependent prostatic hyperplasia develops in the dorsal and lateral lobes of the rat prostate...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29661690/the-history-of-testosterone-and-the-evolution-of-its-therapeutic-potential
#8
REVIEW
Abraham Morgentaler, Abdulmaged Traish
INTRODUCTION: Testosterone therapy has been controversial since its synthesis in the 1930s to the present day. Testosterone's history provides depth and context for current controversies. AIM: To review the history of testosterone therapy from its initial synthesis in the 1930s to the modern day. METHODS: Expert review of the literature. MAIN OUTCOME MEASURES: Impactful events in the history of testosterone. RESULTS: By the 1940s there was already a fascinating literature that described the many symptomatic benefits of testosterone therapy that are recognized today...
April 13, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29658833/gonadopenia-and-aging-in-men
#9
Sandeep Singh Dhindsa, Michael S Irwig, Kathleen Wyne
OBJECTIVE: The decrease in testosterone levels that occurs with aging has become an important clinical issue both due to the growth of the geriatric population and patient interest in testosterone therapy. The decision to assess for testosterone deficiency and the ability to determine whether the benefits exceed the risks require a comprehensive evaluation of the aging patient. This article is part of a series of papers focused on the endocrinology of aging. This review addresses common issues needed for clinical decision making, including how to interpret test results, differential diagnosis, potential impact of testosterone treatment on insulin resistance and cardiovascular disease, and options for therapy...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29656844/association-between-cholesterol-gallstones-and-testosterone-replacement-therapy-in-a-patient-with-primary-hypogonadism
#10
S Squarza, U G Rossi, P Torcia, M Cariati
A 16-year-old boy had a past medical history of primary hypogonadism, due to bilateral anorchia. He presented with gallstones located in the gallbladder and a mild dilatation of the intrahepatic biliary tree. The histology study reported cholesterol gallstones. The patient had been treated with testosterone replacement therapy since infancy. We suggest a possible correlation between testosterone replacement therapy and the presence of cholesterol gallstones.
April 12, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29656500/mitochondria-glycogen-and-lipid-droplets-in-skeletal-muscle-during-testosterone-treatment-and-strength-training-a-randomized-double-blinded-placebo-controlled-trial
#11
R C Jensen, L L Christensen, J Nielsen, H D Schrøder, T Kvorning, K Gejl, K Højlund, D Glintborg, M Andersen
Low testosterone levels in aging men are associated with insulin resistance. Mitochondrial dysfunction, changes in glycogen metabolism, and lipid accumulation are linked to insulin resistance in skeletal muscle. In this randomized, double-blinded, placebo-controlled study, we investigated the effects of six-month testosterone replacement therapy (TRT) and strength training (ST) on mitochondrial, glycogen, and lipid droplet (LD) content in skeletal muscle of aging men with subnormal bioavailable testosterone (BioT) levels...
April 15, 2018: Andrology
https://www.readbyqxmd.com/read/29656047/the-complex-association-between-metabolic-syndrome-and-male-hypogonadism
#12
Christina Dimopoulou, Dimitrios G Goulis, Giovanni Corona, Mario Maggi
BACKGROUND: The complex association between metabolic syndrome (MetS) and male hypogonadism is well established. A number of observational studies show that low testosterone is associated with insulin resistance and an increased risk for diabetes mellitus and MetS in men. AIMS: To elucidate the association between MetS and male hypogonadism, present epidemiological data on the co-existence of the two comorbidities, enlighten the underlying pathophysiology and appraise the effects of testosterone supplementation therapy (TTh) and lifestyle modifications on MetS and body composition in men...
April 12, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29650456/-androgens-and-cardiovascular-risk-a-series-of-case-report-in-the-french-and-canadian-pharmacovigilance-databases
#13
M Rochoy, R Thomas, J Béné, D Deleplanque, M-C Vantyghem, S Gautier, D Deplanque
INTRODUCTION: Age-related androgenic deficiency (DALA) is a pathology that is increasingly cited in recent publications. The cardiovascular risk of testosterone is debated: present for the FDA, absent for the European Medicines Agency in 2015. Our objective was to analyze the association between androgens and vascular pathologies in adverse reactions reported in pharmacovigilance databases. MATERIAL AND METHOD: We conducted a retrospective case series study of the French and Canadian pharmacovigilance databases for the period 2005-2015...
April 9, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29644169/testosterone-replacement-therapy-for-physician-assistants-and-nurse-practitioners
#14
REVIEW
Libert Ramos, Amir Shahreza Patel, Ranjith Ramasamy
Physician assistants (PA) and nurse practitioners have been moving toward specialty practices, like urology. With increased training and education, they manage more complex conditions independently. Whether they are the primary provider or the follow up to a specialist, physician extenders can play a vital role in managing patients undergoing testosterone therapy. Physician extenders should be able to understand the indications, risks and associated adverse effects of administering testosterone in order to proficiently take care of patients with low testosterone...
March 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29642341/re-biometry-of-the-hypospadic-penis-after-hormone-therapy-testosterone-and-estrogen-a-randomized-double-blind-controlled-trial
#15
Douglas A Canning
No abstract text is available yet for this article.
April 2018: Journal of Urology
https://www.readbyqxmd.com/read/29630096/effects-of-testosterone-on-ppar%C3%AE-and-p450arom-expression-in-polycystic-ovary-syndrome-patients-and-related-mechanisms
#16
Y He, C-L Wang
OBJECTIVE: Polycystic ovary syndrome (PCOS) causes ovulation disorder and infertility in female patients. This study recruited PCOS patients and adopted testosterone therapy to analyze its effect on expression of nuclear peroxisome proliferation activated receptor γ (PPARγ), and cytochrome P450 aromatase (P450arom) in ovary granular cells of patients. PATIENTS AND METHODS: PCOS and non-PCOS patients were treated with testosterone at 1.0 nmol/L, 10 nmol/L. qRT-PCR was used to detect the expressions of PPARγ and P450arom while Western blot was performed for the evaluation of protein expression...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29624800/efficacy-and-safety-of-3-month-dosing-regimen-of-degarelix-in-japanese-subjects-with-prostate-cancer-a-phase-iii-study
#17
Seiichiro Ozono, Taiji Tsukamoto, Seiji Naito, Shigeo Horie, Yasuo Ohashi, Hiroji Uemura, Yumiko Yokomizo, Satoshi Fukasawa, Hidehito Kusuoka, Rio Akazawa, Masako Saito, Hideyuki Akaza
Non-inferiority in the cumulative castration rate of the 3-month formulation of degarelix compared with the 3-month formulation of goserelin was evaluated in subjects with prostate cancer. A phase III, open-label, parallel-arm study was conducted. An initial dose of 240 mg of degarelix or 3.6 mg of goserelin was subcutaneously administered; after day 28, a maintenance dose of 480 mg of degarelix or 10.8 mg of goserelin was administered once every 84 days. Non-inferiority in castration rate and safety of degarelix to goserelin were evaluated...
April 6, 2018: Cancer Science
https://www.readbyqxmd.com/read/29624102/exogenous-testosterone-does-not-induce-or-exacerbate-the-metabolic-features-associated-with-pcos-among-transgender-men
#18
Kelly J Chan, Jennifer J Liang, Divya Jolly, Jamie D Weinand, Joshua D Safer
OBJECTIVES: Polycystic ovarian syndrome (PCOS) is a complex condition which can include menstrual irregularity, metabolic derangement, and increased androgen levels. The mechanism of PCOS is unknown. Some suggest that excess production of androgens by the ovaries may cause or exacerbate the metabolic findings. The purpose of this study was to assess the role of increased testosterone on metabolic parameters on individuals presumed to be chromosomally female by examination of these parameters in hormone-treated transgender men...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29623702/testosterone-replacement-muscle-strength-and-physical-function
#19
REVIEW
You Seon Nam, Gyeongsil Lee, Jae Moon Yun, Belong Cho
Muscle strength and physical function decrease in older men, as do testosterone levels. Nonetheless, the effects of testosterone replacement therapy on muscle strength and physical function remain inconclusive and equivocal. We conducted a rapid systematic review, the results of which showed that testosterone replacement does not affect muscle strength (measured by hand grip strength and leg muscle strength), although it may increase physical function (measured by the 6-minute walk test, Physical Activity Scale for the Elderly score, and other physical performance tests)...
March 22, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29623698/shifting-the-paradigm-of-testosterone-replacement-therapy-in-prostate-cancer
#20
REVIEW
Michael A Bell, Jeffrey D Campbell, Gregory Joice, Nikolai A Sopko, Arthur L Burnett
Historically, testosterone and prostate cancer have been demonstrated to have a positive association leading providers to forgo testosterone replacement therapy (TRT) in men with concurrent histories of hypogonadism and prostate cancer. This paradigm has been gradually shifting with our evolving understanding of the relationship between testosterone and prostate cancer and the gaining popularity of the saturation model. Newer data suggests improved quality of life for men with hypogonadism after TRT leading to a more tempered view of the effects of this treatment and its risk in prostate cancer...
March 22, 2018: World Journal of Men's Health
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