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https://www.readbyqxmd.com/read/29453817/endocrine-and-psychological-aspects-of-sexual-dysfunction-in-klinefelter-patients
#1
A Ferlin, R Selice, S Angelini, M Di Grazia, N Caretta, F Cavalieri, A Di Mambro, C Foresta
Klinefelter syndrome is a frequent cause of hypogonadism, but despite hundreds of publications on different aspects of Klinefelter syndrome, only a few studies dealt with sexual dysfunction. In particular, testosterone is critical for various aspects of sexual response, but its role on sexuality in Klinefelter syndrome patients is debatable and no studies have evaluated the efficacy of testosterone treatment on sexual dysfunction in these subjects. Furthermore, the impact of psychological and relational aspects on sexual function of Klinefelter syndrome subjects is poorly defined...
February 17, 2018: Andrology
https://www.readbyqxmd.com/read/29446828/novel-insights-on-testicular-volume-and-testosterone-replacement-therapy-in-klinefelter-patients-undergoing-testicular-sperm-extraction-a-retrospective-clinical-study
#2
Andrea Garolla, Riccardo Selice, Massimo Menegazzo, Umberto Valente, Filiberto Zattoni, Massimo Iafrate, Tommaso Prayer-Galetti, Marina Gardiman Paola, Alberto Ferlin, Andrea Di Nisio, Carlo Foresta
STUDY QUESTION: To investigate whether sperm recovery is related to clinical features, hormone parameters and testosterone replacement therapy (TRT) in patients with Klinefelter syndrome (KS). SUMMARY ANSWER: This study provides three interesting insights: i) the probability to retrieve sperm is not related to testicular volume; ii) TRT does not affect sperm retrieval rate (SRR); iii) reduced levels of LH and FSH represent a negative predictor of sperm retrieval in patients with TRT...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29438472/klinefelter-syndrome-integrating-genetics-neuropsychology-and-endocrinology
#3
Claus H Gravholt, Simon Chang, Mikkel Wallentin, Jens Fedder, Philip Moore, Anne Skakkebæk
Although first identified over 70 years ago, Klinefelter syndrome (KS) continue to pose significant diagnostic challenges, as many patients are still misdiagnosed, or remain undiagnosed. In fact, as few as 25% of KS patients are accurately diagnosed, and most of these diagnoses are not made until adulthood. Classic characteristics of KS include small testes, infertility, hypergonadothropic hypogonadism, and cognitive impairment. However, the pathophysiology behind KS is not well understood, although genetic effects are also thought to play a role...
February 9, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29437711/bilateral-testicular-torsion-in-a-36-week-neonate
#4
Michael J H Clarke, Samuel Crocker, David G Bartle, John Apsey
A male neonate born after uncomplicated vaginal delivery at 36 weeks' gestation was noted to have large and firm testicles bilaterally on routine examination. A testicular ultrasound scan was subsequently organised that showed detailed appearances consistent with bilateral testicular torsion. This was thought to have taken place antenatally and as such was unfortunately not suitable for intervention. The patient was therefore managed conservatively with the testicles left to involute naturally. He was started on testosterone replacement therapy after follow-up when gonadotrophin levels were found to be raised and testosterone low (suggesting absent testicular function) and will be closely followed up regarding his future development which is normal to this point...
February 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29436770/a-review-of-the-role-of-estrogen-in-dermal-aging-and-facial-attractiveness-in-women
#5
REVIEW
Edwin D Lephart
Estrogens are known to have protective and favorable influences on skin health; conversely, androgens oppose the actions of estrogens. Estrogen's chemical messages are transmitted via the classical nuclear hormone estrogen receptors (ER) alpha and beta and the rapid-acting G-coupled membrane estrogen receptor. Androgens [both testosterone and 5α-dihydrotestosterone (5α-DHT)] bind the same androgen receptor. Estrogen levels peak in the mid- to late 20s in women and then decline by 50% by 50 years of age and dramatically decrease further after menopause...
February 13, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29435052/simvastatin-in-combination-with-meclofenamic-acid-inhibits-the-proliferation-and-migration-of-human-prostate-cancer-pc-3-cells-via-an-akr1c3-mechanism
#6
Yoshitaka Sekine, Hiroshi Nakayama, Yoshiyuki Miyazawa, Haruo Kato, Yosuke Furuya, Seiji Arai, Hidekazu Koike, Hiroshi Matsui, Yasuhiro Shibata, Kazuto Ito, Kazuhiro Suzuki
Statins have become of interest in research due to their anticancer effects. However, the exact mechanism of their anticancer properties remains unclear. The authors previously reported that statins decrease intracellular cholesterol levels in androgen-independent prostate cancer cells. In de novo androgen synthesis, cholesterol is the primary material and certain enzymes have important roles. The present study aimed to determine whether simvastatin alters the expression of androgen synthesis-associated enzymes in androgen-independent prostate cancer cells...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434814/metformin-and-pioglitazone-combination-therapy-ameliorate-polycystic-ovary-syndrome-through-ampk-pi3k-jnk-pathway
#7
Yuanyuan Wu, Pengfen Li, Dan Zhang, Yingpu Sun
Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder, which results in health problems such as menstrual disorders, hyperandrogenism and persistent anovulation. Hyperandrogenism and insulin resistance are the basic characteristics of PCOS. To investigate the combined effect of metformin and pioglitazone on POCS and the potential mechanisms, a rat model of PCOS was established by intramuscular injection of estradiol valerate (EV). The effect of metformin and pioglitazone monotherapy or combination therapy in control rats and PCOS rats was evaluated, involving the testosterone level, follicular development and insulin resistance...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29431612/testosterone-therapy-in-hypogonadal-men
#8
(no author information available yet)
No abstract text is available yet for this article.
February 5, 2018: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/29430665/health-related-physical-fitness-and-quality-of-life-in-men-with-congenital-hypogonadotropic-hypogonadism
#9
K S L Mileski, M Bottaro, L G Grossi-Porto, A Lofrano-Porto
Congenital hypogonadotropic hypogonadism is a rare disorder characterised by impaired testosterone secretion since birth, and represents a valuable model for studying the effects of testosterone replacement therapy (TRT) in humans. This cross-sectional study aimed to investigate all health-related physical fitness (HRPF) components and quality of life in a series of eight men with hypogonadotropic hypogonadism under regular TRT. The study group was compared to a control group of 16 healthy subjects paired for age, body mass index and physical activity...
February 11, 2018: Andrologia
https://www.readbyqxmd.com/read/29427323/androgen-receptor-dampens-tissue-factor-expression-via-nf-%C3%AE%C2%BAb-and-egr1
#10
Bastian Hoesel, Marion Mussbacher, Burak Dikorman, Manuel Salzmann, Alice Assinger, Lena Hell, Johannes Thaler, José Basílio, Bernhard Moser, Ulrike Resch, Hannah Paar, Nigel Mackman, Johannes A Schmid
BACKGROUND: Prostate cancer is one of the leading causes of cancer death in men. Advanced prostate cancer is usually treated by androgen deprivation therapy (ADT), which aims at diminishing circulating testosterone to reduce cancer growth. There is growing evidence that ADT can increase the rate of venous thromboembolism (VTE) in prostate cancer patients. The tissue factor (TF) gene is one of the most important mediators of coagulation and VTE, but so far there is limited data on androgen receptor (AR) mediated TF gene expression...
February 10, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29425664/topical-testosterone-therapy-adherence-and-outcomes-among-men-with-primary-or-secondary-hypogonadism
#11
Michael Grabner, Zsolt Hepp, Amit Raval, Fang Tian, Mohit Khera
BACKGROUND: Men with primary or secondary hypogonadism (HG) prescribed testosterone therapy (TTh) who terminate treatment early might not obtain the benefit of symptom relief. AIM: To estimate adherence to topical TTh and to compare baseline characteristics and follow-up outcomes between adherent and non-adherent patients in a population of commercially insured US men with primary or secondary HG. METHODS: A retrospective cohort of adult men with primary or secondary HG and initiating topical TTh from 2007 through 2014, with continuous coverage during 12-month baseline and follow-up periods, was identified from a large US health plan...
February 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29423003/direct-conversion-of-human-fibroblasts-into-functional-leydig-like-cells-by-sf-1-gata4-and-ngfi-b
#12
Yan-Ping Hou, Zhi-Yuan Zhang, Xiao-Yu Xing, Jin Zhou, Jie Sun
The reprogramming of fibroblasts to induced pluripotent stem cells raises the possibility that a somatic cell can be reprogrammed to an alternative, differentiated fate without first becoming a stem/progenitor cell. Recent work has shown that fibroblasts can be reprogrammed to other, terminally differentiated cells with a combination of several transcription factors. Here, we report that a combination of four developmental transcription factors; GATA4, SF-1, NGFI-B, and COUP TF2; efficiently reprogrammed human foreskin fibroblasts into functional induced Leydig-like cells (iLCs)...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29421437/effects-of-acupuncture-on-the-levels-of-serum-estradiol-and-pituitary-estrogen-receptor-beta-in-a-rat-model-of-induced-super-ovulation
#13
Haiyang Fu, Jianhua Sun, Yong Tan, Huifang Zhou, Wanli Xu, Junling Zhou, Dong Chen, Cong Zhang, Xuanxuan Zhu, Ying Zhang, Xiaoliang Wu, Zhaoqing Xi
AIMS: Acupuncture is frequently recommended as a complementary therapy for infertility. However, whether acupuncture can prevent early ovarian hyperstimulation syndrome has not been examined and its potential mechanisms are not well understood. MAIN METHODS: Forty rats were randomized into four groups: Control, Ovarian Stimulation Model, Acupuncture, and Human Chorionic Gonadotropin (HCG). Serum estradiol, progesterone, testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels were measured by enzyme-linked immunosorbent assay...
February 5, 2018: Life Sciences
https://www.readbyqxmd.com/read/29419855/-clinical-report-of-testicular-hypoplasia-combined-with-21-hydroxylase-deficiency
#14
Bo Jiang, Dingyuan Ma, Huanhuan Chen, Xiaoyu Yang, Yugui Cui, Zhengfeng Xu, Jiayin Liu
OBJECTIVE To investigate the correlation of 21-hydroxylase deficiency (21-OHD) with male testicular dysplasia. METHODS Clinical data of 8 infertile males with congenital adrenal hyperplasia due to 21-OHD was retrospectively analyzed. In addition, potential mutations of the CYP21A2 gene was detected. RESULTS All patients were referred because of azoospermia or severe oligospermia and had small testis with averaged testicular volume of 6.1 mL. Three patients had testicular adrenal rest tumors. Endocrinologic examinations revealed low levels of leutinizing hormone and follicular stimulating hormone, normal or elevated testosterone, elevated progesterone, elevated or normal adrenocoticotropic hormone, and low or normal cortisol...
February 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29411194/sarcopenia
#15
REVIEW
Karsten Keller
Sarcopenia is a very common, but frequently overlooked and undertreated geriatric syndrome comprising pronounced muscle mass and strength/performance loss. Estimated prevalence is between 5 and 40% in the general population, accompanied by an exponential incline with increasing age. Sarcopenia is connected to atrophy and loss of muscle fibers and motor units, affecting primarily the fast-twitch muscle fibers und their motor units. Fast-twitch muscle fibers seem to be more prone to failure of function and loss over time...
February 6, 2018: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29406064/hypogonadism-therapeutic-risks-benefits-and-outcomes
#16
REVIEW
John T Sigalos, Alexander W Pastuszak, Mohit Khera
Hypogonadism is a common condition defined by the presence of low serum testosterone levels and hypogonadal symptoms, and most commonly treated using testosterone therapy (TTh). The accuracy of diagnosis and appropriateness of treatment, along with proper follow-up, are increasingly important given the large increase in testosterone prescriptions and the recent concern for cardiovascular (CV) risk associated with TTh. In March of 2015, the US Food and Drug Administration required that testosterone product labels disclose a potential CV risk, despite the evidence base for this association being weak and inconclusive...
March 2018: Medical Clinics of North America
https://www.readbyqxmd.com/read/29405166/testosterone-replacement-therapy-dilemmas-and-challenges-in-china-and-asia
#17
Qi An, Yi-Qun Gu
No abstract text is available yet for this article.
February 2, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29401540/eighteen-year-effect-of-androgen-therapy-on-bone-mineral-density-in-trans-gender-men
#18
Petr Dan Broulik, Václav Urbánek, Petr Libanský
The study explores the influence of long-term androgen supplementation (18 years) on bone metabolism in trans(gender) men. Thirty five trans(gender) men aged (47±4) were treated with adequate dose of testosterone. BMD was measured by DEXA at lumbar spine and neck and T score was determined. Biochemical parameters of bone turnover were measured in all patients. As compared with female and male age matched controls they showed a not significantly different T-score at spine [1.213±0.15 in trans(gender) men vs...
February 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29396841/metabolic-phenotype-of-male-obesity-related-secondary-hypogonadism-pre-replacement-and-post-replacement-therapy-with-intra-muscular-testosterone-undecanoate-therapy
#19
Georgios K Dimitriadis, Harpal S Randeva, Saboor Aftab, Asad Ali, John G Hattersley, Sarojini Pandey, Dimitris K Grammatopoulos, Georgios Valsamakis, Georgios Mastorakos, T Hugh Jones, Thomas M Barber
AIM: To explore the metabolic phenotype of obesity-related secondary hypogonadism (SH) in men pre-replacement and post-replacement therapy with long-acting intramuscular (IM) testosterone undecanoate (TU). METHODS: A prospective observational pilot study on metabolic effects of TU IM in male obesity-related SH (hypogonadal [HG] group, n = 13), including baseline comparisons with controls (eugonadal [EG] group, n = 15). Half the subjects (n = 7 in each group) had type 2 diabetes mellitus (T2D)...
February 2, 2018: Endocrine
https://www.readbyqxmd.com/read/29396819/severe-secondary-polycythemia-in-a-female-to-male-transgender-patient-while-using-lifelong-hormonal-therapy-a-patient-s-perspective
#20
Ellen G T Ederveen, Florence P A M van Hunsel, Marielle J Wondergem, Eugène P van Puijenbroek
After a registered drug is available on the market and used in everyday circumstances, hitherto unknown adverse drug reactions (ADRs) may occur. Furthermore, the patient can experience a previously unknown course of a known ADR. Voluntary reports by patients play an important role in gaining knowledge about ADRs in daily practice. The Netherlands Pharmacovigilance Centre Lareb received a report from a 55-year-old female-to-male transgender patient who experiences secondary polycythemia while using lifelong testosterone therapy...
February 2, 2018: Drug Safety—Case Reports
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