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https://www.readbyqxmd.com/read/29051056/recovery-of-serum-testosterone-levels-and-sexual-function-in-patients-treated-with-short-term-luteinizing-hormone-releasing-hormone-antagonist-as-a-neoadjuvant-therapy-before-external-radiotherapy-for-intermediate-risk-prostate-cancer-preliminary-prospective
#1
Takahiro Inoue, Takashi Mizowaki, Daijiro Kabata, Ayumi Shintani, Naoki Terada, Toshinari Yamasaki, Hiromitsu Negoro, Takashi Kobayashi, Kiyonao Nakamura, Haruo Inokuchi, Osamu Ogawa
INTRODUCTION: External beam radiation therapy (EBRT) with short-term androgen deprivation therapy is the standard of care for intermediate-risk prostate cancer patients. However, no study to date has evaluated the hormonal kinetics or sexual and hormonal function recovery after cessation of short-term luteinizing hormone (LH)-releasing hormone (LHRH) antagonist treatment. PATIENTS AND METHODS: Ten intermediate-risk prostate cancer patients (mean age, 69.9 years) were included...
September 23, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29044613/effect-of-androgen-deprivation-therapy-on-the-contractile-properties-of-type-i-and-type-ii-skeletal-muscle-fibres-in-men-with-non-metastatic-prostate-cancer
#2
C R Lamboley, H Xu, T L Dutka, E D Hanson, A Hayes, J A Violet, R M Murphy, G D Lamb
The contractile properties of vastus lateralis muscle fibres were examined in prostate cancer (PrCa) patients undergoing androgen deprivation therapy (ADT) and in age- and activity-matched healthy male subjects (Control). Mechanically-skinned muscle fibres were exposed to a sequence of heavily Ca(2+) -buffered solutions at progressively higher free [Ca(2+) ] to determine their force-Ca(2+) relationship. Ca(2+) -sensitivity was decreased in both type I and type II muscle fibres of ADT subjects relative to Controls (by -0...
October 17, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29044447/relationship-between-androgen-deficiency-and-memory-impairment-in-aging-and-alzheimer-8217-s-disease
#3
Graciela Jiménez-Rubio, José J Herrera-Pérez, Olivia T Hernández-Hernández, Lucía Martínez-Mota
Aging and Alzheimer’s disease (AD) are associated with a declination of cognition and memory, whose severity increases in AD. Recent investigations point to a greater participation of neurofibrillary tangles (NFTs) than that of senile plaques, as responsible for cognitive impairment in AD and normal aging. On the other hand, aging is related with reduced levels of dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) as well as testosterone (T). Basic and clinical studies give evidence that hypoandrogenism is associated with memory impairment...
September 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29040227/testosterone-supplementation-and-retinal-vascular-disease
#4
Vaidehi S Dedania, David N Zacks, Wei Pan, Brian L VanderBeek
PURPOSE: To determine whether testosterone supplementation is associated with retinal artery occlusion (RAO) or retinal vein occlusion (RVO). METHODS: Retrospective matched cohort study using data from a large national U.S. insurance database. The testosterone cohort consisted of all male patients who filled a prescription for testosterone from 2000 to 2013. Five controls were matched on age (±3 years), sex, race, and similar time in plan (±3 months) for every exposed patient...
October 13, 2017: Retina
https://www.readbyqxmd.com/read/29040226/propranolol-and-oxandrolone-therapy-accelerated-muscle-recovery-in-burned-children
#5
Tony Chao, Craig Porter, David N Herndon, Aikaterina Siopi, Henry Ideker, Ronald P Mlcak, Labros S Sidossis, Oscar E Suman
INTRODUCTION: Severe burns result in prolonged hypermetabolism and skeletal muscle catabolism. Rehabilitative exercise training (RET) programs improved muscle mass and strength in severely burned children. The combination of RET with β-blockade or testosterone analogues showed improved exercise-induced benefits on body composition and muscle function. However, the effect of RET combined with multiple drug therapy on muscle mass, strength, cardiorespiratory fitness and protein turnover are unknown...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29039422/drug-development-for-noncastrate-prostate-cancer-in-a-changed-therapeutic-landscape
#6
REVIEW
Min Yuen Teo, Matthew J O'Shaughnessy, Sean M McBride, Herbert A Vargas, Howard I Scher
The unprecedented progress in the treatment of metastatic castration-resistant prostate cancer is only beginning to be realized in patients with noncastrate disease. This slow progress in part reflects the use of trial objectives focused on time-to-event end points, such as time to metastasis and overall survival, which require long follow-up durations and large sample sizes, and has been further delayed by the use of approved therapies that are effective at the time of progression. Our central hypotheses are that progress can be accelerated, and that outcomes can be improved by shifting trial objectives to response measures occurring early that solely reflect the effects of the treatment...
October 17, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29034138/testosterone-pellet-associated-dermatitis-report-and-review-of-testopel-related-cutaneous-adverse-effects
#7
Lucas A Heldt Manica, Philip R Cohen
Testosterone replacement therapy is a treatment utilized for male hypogonadism. A subcutaneous testosterone pellet is a long-acting, slow-release delivery system that can be utilized as androgen replacement therapy. A 77-year-old man who was treated with testosterone pellets developed dermatitis consisting of erythematous plaques and patches on both buttocks and thighs within 28 days following the subcutaneous insertion of testosterone pellets. The skin lesions rapidly resolved with high-potency topical corticosteroid application...
August 11, 2017: Curēus
https://www.readbyqxmd.com/read/29026762/correlation-of-vitamin-d-with-metabolic-parameters-in-polycystic-ovarian-syndrome
#8
Arun Kumar, Satish Barki, Vinod Raghav, Ashutosh Chaturvedi, K V S Hari Kumar
BACKGROUND: Polycystic ovarian syndrome (PCOS) and hypovitaminosis D are the two most common endocrine disorders in young women leading to many adverse metabolic consequences. We evaluated the correlation of 25-hydroxy Vitamin D (25OHD) with metabolic parameters and insulin resistance in PCOS. MATERIALS AND METHODS: We included 100 PCOS patients (age 18-40 years, duration >6 months) serially, in this cross-sectional study. We excluded patients with past use of insulin sensitizers and hormone therapy...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29024781/the-role-of-androgen-receptors-in-atherosclerosis
#9
REVIEW
Kaloyan Takov, Junxi Wu, Martin A Denvir, Lee B Smith, Patrick W F Hadoke
Male disadvantage in cardiovascular health is well recognised. However, the influence of androgens on atherosclerosis, one of the major causes of many life-threatening cardiovascular events, is not well understood. With the dramatic increase in clinical prescription of testosterone in the past decade, concerns about the cardiovascular side-effects of androgen supplementation or androgen deprivation therapy are increasing. Potential atheroprotective effects of testosterone could be secondary to (aromatase-mediated) conversion into oestradiol or, alternatively, to direct activation of androgen receptors (AR)...
October 9, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29022642/induction-of-puberty-with-human-chorionic-gonadotropin-hcg-followed-by-reversal-of-hypogonadotropic-hypogonadism-in-kallmann-syndrome
#10
Malgorzata Maria Pierzchlewska, Maciej Grzegorz Robaczyk, Ida Vogel
INTRODUCTION: Kallmann syndrome (KS) is a rare, congenital disorder combining hypogonadotropic hypogonadism (HH) due to GnRH-deficiency with anosmia. Traditionally thought to require lifelong therapy it turns out to be a reversible condition in some patients. CASE REPORT: We present a case of a 22-year old man with absent puberty due to KS, in whom genetic testing revealed heterozygosity for a mutation in the PROK2 gene. Pubertal development and virilisation was achieved by using human chorionic gonadotropin (hCG) injections followed by testosterone replacement...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29020729/diagnosing-and-managing-androgen-deficiency-in-men
#11
Raveen Kaur Sandher, Jonathan Aning
Androgens play a crucial role in bone, muscle and fat metabolism, erythropoiesis and cognitive health. In men aged 40-79 years the incidence of biochemical deficiency and symptomatic hypogonadism is 2.1-5.7%. Decreased libido or reduced frequency and quality of erections, fatigue, irritability, infertility or a diminished feeling of wellbeing may be presenting complaints. However, a significant proportion of men with androgen deficiency will be identified when they present for unrelated concerns. Important factors to elicit from the history in addition to the presenting complaint include: a medical history of obesity, type 2 diabetes, systemic diseases or metabolic syndrome which all impact on testosterone physiology...
April 2017: Practitioner
https://www.readbyqxmd.com/read/29020683/combination-of-androgen-deprivation-therapy-and-salvage-radiotherapy-versus-salvage-radiotherapy-alone-for-recurrent-prostate-cancer-after-radical-prostatectomy
#12
Sangjun Yoo, Dalsan You, Young Seok Kim, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
INTRODUCTION: To assess the value of androgen deprivation therapy (ADT) on salvage radiotherapy (RT) in post-prostatectomy recurrent prostate cancer patients, we compared the oncologic outcomes between patients receiving RT + ADT and those receiving RT alone. MATERIALS AND METHODS: We reviewed the records of patients diagnosed with prostate cancer between 1995 and 2011, including 93 patients who underwent salvage RT and 69 patients who underwent salvage RT + ADT...
October 12, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29020437/does-testosterone-therapy-raise-the-risk-of-vte
#13
EDITORIAL
Jonathan Rees
No abstract text is available yet for this article.
December 2016: Practitioner
https://www.readbyqxmd.com/read/29020429/pachychoroid-pigment-epitheliopathy-associated-with-tamoxifen
#14
Mehmet Giray Ersoz, Serra Arf, Murat Karacorlu, Mumin Hocaoglu, Isil Sayman Muslubas
Pachychoroid pigment epitheliopathy (PPE) is considered to be a forme fruste of central serous chorioretinopathy. Tamoxifen (Soltamax; Midatech Pharma, Raleigh, NC) has an anti-estrogenic effect on cytoplasmic estrogen receptors. Serum total testosterone, cortisol, and cortisone levels increase during tamoxifen therapy. Tamoxifen may cause hormone disturbance leading to the development of disorders in the pachychoroid spectrum. The authors present two cases of PPE associated with tamoxifen therapy. A 65-year-old woman (Patient 1) and a 52-year-old woman (Patient 2) had a recent history of tamoxifen therapy...
October 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29018642/pulmonary-embolism-secondary-to-testosterone-enhancing-herbal-supplement-use
#15
Steven M Nguyen, Nway Ko Ko, Asad S Sattar, Esra Gucuk Ipek, Sayed Ali
Decreased testosterone levels in men are often a normal sign of aging. Testosterone replacement therapy (TRT) is a well-established option for those with symptomatic hypogonadism related to low testosterone levels. Conversely, designer herbal supplements in the context of testosterone supplementation are poorly studied, yet remain popular among aging men who seek the well-known, often enhancing, effects of testosterone that involve muscle mass and sexual function/drive. In 2014, the Food and Drug Administration (FDA) issued a warning about the significant risk of venous clots secondary to testosterone product use...
August 6, 2017: Curēus
https://www.readbyqxmd.com/read/28994096/impaired-expression-of-testicular-androgen-receptor-and-collagen-fibers-in-the-testis-of-diabetic-rats-under-haart-the-role-of-hypoxis-hemerocallidea
#16
Onanuga O Ismail, Jegede I Ayoola, Offor Ugochukwu, Ogedengbe O Oluwatosin, Peter I Aniekan, Naidu C S Edwin, Azu O Onyemaechi
INTRODUCTION: Wide spectrum of alterations associated with highly active antiretroviral therapy (HAART) has been reported. The current study aimed at evaluating the role of Hypoxis hemerocallidea (HH) aqueous extract on the testosterone levels, expression of androgen receptors and collagen fibers in the testes of streptozotocin-nicotinamide-induced diabetic rats under HAART regimen. MATERIAL AND METHODS: Sixty two adult male Sprague-Dawley rats (189.0 ± 4.5 g) were divided into eight groups (8 animals in each treatment groups and 6 rats in the control group)...
October 10, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28992799/significant-symptomatic-improvement-of-subacute-cutaneous-lupus-after-testosterone-therapy-in-a-female-to-male-transgender-subject
#17
A Ocon, R Peredo-Wende, J M Kremer, B D Bhatt
No abstract text is available yet for this article.
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28990951/testosterone-replacement-therapy-and-cardiovascular-events
#18
Alp Burak Çatakoğlu, Muammer Kendirci
A low testosterone level and hypogonadism are associated with cardiovascular disease. Aging, chronic health problems, and obesity are all associated with a low testosterone level as well as the presence and severity of cardiovascular disease. Testosterone is increasingly prescribed for patients with clinical hypogonadism and a low testosterone level. The information we have is still contradictory regarding testosterone replacement therapy (TRT) and its association with adverse cardiovascular events. Older patients and patients who are susceptible to cardiovascular diseases could be at risk with a testosterone prescription...
October 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28989874/metabolic-status-and-hypogonadism-in-human-immunodeficiency-virus-infected-males
#19
Sarita Bajaj, Yashaswi Pathak, Sharad Varma, Sujit Verma
AIMS AND OBJECTIVES: The aim of this study is to determine the prevalence of hypogonadism in human immunodeficiency virus (HIV)-infected males and to study its relation to age, CD4 count, body mass index (BMI), duration of highly active antiretroviral therapy (HAART), and metabolic status. METHODOLOGY: Eighty-one HIV positive cases and 82 healthy controls were included in this case-control study. Each case underwent a complete physical examination and serum fasting plasma glucose, A1c, lipid profile, total testosterone (TT), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels were estimated...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28988938/testosterone-therapy-in-a-man-with-intermediate-risk-prostate-cancer-pro
#20
Abraham Morgentaler
The original prohibition of testosterone therapy for men with prostate cancer was based on outdated concepts developed more than 70 yr ago. Current evidence, although limited, provides consistently reassuring results that testosterone therapy may be reasonably offered to many men with prostate cancer. These men may experience valuable benefits in quality of life if they suffer from symptoms of testosterone deficiency (hypogonadism).
October 5, 2017: European Urology Focus
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