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Testosterone therapy

E Lichar Dillon, Melinda Sheffield-Moore, William J Durham, Lori L Ploutz-Snyder, Jeffrey W Ryder, Christopher P Danesi, Kathleen M Randolph, Charles R Gilkison, Randall J Urban
INTRODUCTION: Prolonged confinement to head-down bed rest (HDBR) results in musculoskeletal losses similar to those observed during long duration space flight. Exercise countermeasures by themselves have not completely prevented the deleterious losses in muscle mass or function in HDBR or space flight. PURPOSE: The objective was to investigate the safety and efficacy of intermittent, low-dose testosterone treatment in conjunction with NASA exercise (SPRINT) countermeasures during 70 days of 6° HDBR...
March 26, 2018: Medicine and Science in Sports and Exercise
Sean C Skeldon, Bruce Carleton, James Brophy, Mohit Sodhi, Mahyar Etminan
OBJECTIVE: Case reports have suggested an increased risk of gynecomastia with HMG-CoA reductase inhibitors (i.e. statins). A recent meta-analysis also found that statins decrease circulating testosterone levels in men. We investigated whether statin use was associated with an increased risk of gynecomastia. DESIGN: Case control study. PATIENTS: A cohort of patients from a random sample of 9,053,240 US subjects from the PharMetrics Plus™ health claims database from 2006 to 2016 was created...
June 19, 2018: Clinical Endocrinology
Daniel J Tobiansky, Kathryn G Wallin-Miller, Stan B Floresco, Ruth I Wood, Kiran K Soma
Multiple lines of evidence indicate that androgens, such as testosterone, modulate the mesocorticolimbic system and executive function. This review integrates neuroanatomical, molecular biological, neurochemical, and behavioral studies to highlight how endogenous and exogenous androgens alter behaviors, such as behavioral flexibility, decision making, and risk taking. First, we briefly review the neuroanatomy of the mesocorticolimbic system, which mediates executive function, with a focus on the ventral tegmental area (VTA), nucleus accumbens (NAc), medial prefrontal cortex (mPFC), and orbitofrontal cortex (OFC)...
2018: Frontiers in Endocrinology
Evan Sehn, Cassidy Mozak, Nese Yuksel, Cheryl A Sadowski
OBJECTIVE: To describe the quality of online information on testosterone replacement therapy (TRT) in men. METHODS: A quantitative content analysis was conducted on websites providing patient-directed information on TRT for the purpose of treating late onset hypogonadism (LOH). Websites were identified through Google in March 2017. The DISCERN instrument was used to determine the quality of health information. RESULTS: A total of 20 websites met inclusion criteria...
June 20, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
Gustavo Monnerat, Fernando A C Seara, Joseph Albert Medeiros Evaristo, Gabriel Carneiro, Geisa Paulino Caprini Evaristo, Gilberto Domont, Jose Hamilton Matheus Nascimento, Jose Geraldo Mill, Fabio Cesar Souza Nogueira, Antonio Carlos Campos de Carvalho
Aging is a complex process that increases the risk of chronic disease development. Hormonal and metabolic alterations occur with aging, such as androgen activity decrease. Studies aim to understand the role of testosterone replacement therapy (TRT) in males, however biomarkers and the metabolic responses to TRT are not well characterized. Therefore, the present study investigated TRT effect in young adult and aged rats by metabolomics. Male Wistar rats were divided into four groups: adult and adult + testo (6months), old and old + testo (25-27months)...
June 16, 2018: Journal of Steroid Biochemistry and Molecular Biology
N Brusselaers, R M Tamimi, P Konings, B Rosner, H-O Adami, J Lagergren
Background: There are considerable knowledge gaps concerning different estrogen and progestin formulations, regimens, and modes of administration of menopausal hormone therapy and the risk of breast cancer. Our objective was to assess the different treatment options for menopausal hormone therapy and the risk of breast cancer. Patients and methods: This Swedish prospective nationwide cohort study included all women who received ≥1 hormone therapy prescription during the study period 2005-2012 (290,186 ever-users), group-level matched (1:3) to 870,165 never-users; respectively 6,376 (2...
June 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
L Elaine Waetjen, Sybil L Crawford, Po-Yin Chang, Barbara D Reed, Rachel Hess, Nancy E Avis, Sioban D Harlow, Gail A Greendale, Sheila A Dugan, Ellen B Gold
OBJECTIVE: To evaluate factors associated with incident self-reported vaginal dryness and the consequences of this symptom across the menopausal transition in a multiracial/ethnic cohort of community-dwelling women. METHODS: We analyzed questionnaire and biomarker data from baseline and 13 approximately annual visits over 17 years (1996-2013) from 2,435 participants in the Study of Women's Health Across the Nation, a prospective cohort study. We used discrete-time Cox proportional-hazards regression to identify predictors of incident vaginal dryness and to evaluate vaginal dryness as a predictor of pain during intercourse and changes in sexual intercourse frequency...
June 18, 2018: Menopause: the Journal of the North American Menopause Society
Laura Bregieiro Fernandes Costa, Ana Carolina Japur de Sá Rosa-E-Silva, Sebastião Freitas de Medeiros, Andrea Prestes Nacul, Bruno Ramalho de Carvalho, Cristina Laguna Benetti-Pinto, Daniela Angerame Yela, Gustavo Arantes Rosa Maciel, José Maria Soares Júnior, Técia Maria de Oliveira Maranhão
Gender incongruence is defined as a condition in which an individual self-identifies and desires to have physical characteristics and social roles that connote the opposite biological sex. Gender dysphoria is when an individual displays the anxiety and/or depression disorders that result from the incongruity between the gender identity and the biological sex. The gender affirmation process must be performed by a multidisciplinary team. The main goal of the hormone treatment is to start the development of male physical characteristics by means of testosterone administration that may be offered to transgender men who are 18 years old or over...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
N Bourcigaux, C Rubino, I Berthaud, M E Toubert, B Donadille, L Leenhardt, I Petrot-Keller, S Brailly-Tabard, J Fromigué, F de Vathaire, T Simon, J P Siffroi, M Schlumberger, P Bouchard, S Christin-Maitre
STUDY QUESTION: What are the consequences of radioactive iodine (RAI) therapy for testicular function? SUMMARY ANSWER: A single activity of 3.7 GBq RAI for differentiated thyroid carcinoma (DTC) treatment in young men transiently altered Sertoli cell function and induced sperm chromosomal abnormalities. WHAT IS KNOWN ALREADY: Few studies, mainly retrospective, have reported the potential impacts of RAI on endocrine and exocrine testicular function...
June 15, 2018: Human Reproduction
Kshitij Verma, Nehal Gupta, Tianzhu Zang, Phumvadee Wangtrakuldee, Sanjay K Srivastava, Trevor M Penning, Paul C Trippier
Aldo-keto reductase 1C3 (AKR1C3) also known as type 5 17 β-hydroxysteroid dehydrogenase is responsible for intratumoral androgen biosynthesis, contributing to the development of castration-resistant prostate cancer (CRPC) and eventual chemotherapeutic failure. Significant upregulation of AKR1C3 is observed in CRPC patient samples and derived CRPC cell lines. As AKR1C3 is a downstream steroidogenic enzyme synthesizing intratumoral testosterone (T) and 5α-dihydrotestosterone (DHT), the enzyme represents a promising therapeutic target to manage CRPC and combat the emergence of resistance to clinically employed androgen deprivation therapy...
June 11, 2018: Molecular Cancer Therapeutics
Alexios S Antonopoulos, Charalambos Antoniades
Evidence from clinical studies suggests that patients with low testosterone levels are at increased cardiovascular disease risk. Even though the exact mechanisms remain poorly understood, low plasma testosterone is associated with a pro-atherogenic lipid profile, insulin resistance and increased levels of pro-inflammatory mediators, and vascular dysfunction which is typically observed in patients with hypogonadism. Furthermore, recent evidence suggests that testosterone deficiency has also direct adverse effects on endothelium and nitric oxide bioavailability...
June 8, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
Ling-Yu Shen, Cui-Mei Liang, Wen-Jin Yang, Liang Pan, Hua Li, Hui Hu
OBJECTIVE: To explore the therapeutic effect of acupuncture in the treatment of polycystic ovarian syndrome (PCOS) patients with abdominal obesity by regulating glucose metabolism, insulin resistance, sex hormones, etc. METHODS: Eligible PCOS volunteers were randomly divided into treatment group( n =30) and control group( n =28). The treatment group received acupuncture therapy three times a week combined with diet control and exercise. EA (2 Hz/100 Hz, 4-8 mA) was applied to bilateral Daimai (GB 26)and Tianshu (ST 25) for 20 min/time, and bilateral Daheng (SP 15), Shenshu (BL 23), Ciliao (BL 32), Guilai (ST 29), Zulinqi (GB 41) and Waiguan (SJ 5) were stimulated with filiform needles, with the needles retained for 20 min...
April 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
J F Mao, X Wang, B Q Yu, Y J Gao, M Nie, X Y Wu
Objective: To investigate the clinical features and management of male patients with adult-onset idiopathic hypogonadotropic hypogonadism (AIHH). Methods: Clinical features and treatment of six patients with AIHH between January 2010 and June 2017 were retrospectively reviewed. Results: The patients were all male, with an age of 26 (20-35) years old and they experienced complete pubertal development. The main complaints were decreased libido, erectile dysfunction and gynecomastia. Physical examination found that the testicular size was 15 (12-20) ml and they were fully virilized...
May 29, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Robert Carrasquillo, Kevin Chu, Ranjith Ramasamy
PURPOSE OF REVIEW: Hypogonadism and the treatment of low testosterone is increasingly a subject of medical inquiry and controversy. The few treatments that are FDA-approved such as testosterone topicals, injections, and pellets create significant demand from patients for treatments with more convenient means of administration, fewer adverse effects, and the ability to maintain male fertility. Off-label drugs are in abundant use for low testosterone, including selective estrogen receptor modulators, gonadotropins, and aromatase inhibitors...
June 9, 2018: Current Urology Reports
Dana M Otzel, Jimmy Lee, Fan Ye, Stephen E Borst, Joshua F Yarrow
Neuromuscular impairment and reduced musculoskeletal integrity are hallmarks of spinal cord injury (SCI) that hinder locomotor recovery. These impairments are precipitated by the neurological insult and resulting disuse, which has stimulated interest in activity-based physical rehabilitation therapies (ABTs) that promote neuromuscular plasticity after SCI. However, ABT efficacy declines as SCI severity increases. Additionally, many men with SCI exhibit low testosterone, which may exacerbate neuromusculoskeletal impairment...
June 7, 2018: International Journal of Molecular Sciences
Abdul Basit, John K Amory, Bhagwat Prasad
Development of an oral testosterone (T) therapy has proven extremely challenging because of extensive and variable first-pass metabolism. We investigated the in vivo metabolism of T with increasing oral doses of T, both alone and with the co-administration of dutasteride (5α-reductase inhibitor) by LC-MS/MS. In eugonadal men prior to dosing, the circulating concentration of T, androstenedione, etiocholanolone-glucuronide, and androsterone-glucuronide was 8.6, 20.9, 9.1 and 55.3%, respectively, of the total T-related species, whereas T-glucuronide was ∼1%...
June 7, 2018: Clinical and Translational Science
Bindu Kulshreshtha, Smit Rajput, Scienthia Sanjeevani
We recently came across an interesting article by Dixon et al entitled "Prolonged human chorionic gonadotrophin stimulation as a tool for investigating and managing undescended testes" published in 2007 in your journal(1). The authors showed that around 30% of cryptorchid males had peak rise in testosterone at day 22 after a prolonged HCG stimulation for 2 weeks. While there are no set protocols, HCG therapy for undescended testes (UDT)in varying doses is usually given for a period of 2-6 weeks. This article is protected by copyright...
June 7, 2018: Clinical Endocrinology
Nathan J Alder, Sorena Keihani, Gregory J Stoddard, Jeremy B Myers, James M Hotaling
OBJECTIVES: To assess the efficacy and safety of combination therapy with clomiphene citrate (CC) and anastrozole (AZ) for male hypoandrogenism. PATIENTS AND METHODS: We identified patients treated with a combination of CC + AZ in the period 2014 to 2017. Data were gathered on patient characteristics and laboratory values at baseline. Total testosterone, bioavailable testosterone, oestradiol and testosterone:oestradiol ratio were measured before combination therapy (treatment with CC only) and at CC + AZ combination therapy follow-ups...
June 6, 2018: BJU International
Hung-Ming Lam, Eva Corey
No abstract text is available yet for this article.
2018: Frontiers in Oncology
James A Simon, Irwin Goldstein, Noel N Kim, Susan R Davis, Susan Kellogg-Spadt, Lior Lowenstein, JoAnn V Pinkerton, Cynthia A Stuenkel, Abdulmaged M Traish, David F Archer, Gloria Bachmann, Andrew T Goldstein, Rossella E Nappi, Linda Vignozzi
OBJECTIVE: The objective of this consensus document is to broaden the perspective on clinical management of genitourinary syndrome of menopause to include androgens. METHODS: A modified Delphi method was used to reach consensus among the 14 international panelists representing multiple disciplines and societies. RESULTS: Menopause-related genitourinary symptoms affect over 50% of midlife and older women. These symptoms have a marked impact on sexual functioning, daily activities, emotional well-being, body image, and interpersonal relations...
June 4, 2018: Menopause: the Journal of the North American Menopause Society
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