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https://www.readbyqxmd.com/read/28647502/alternative-complement-pathway-hemolytic-assays-reveal-incomplete-complement-blockade-in-patients-treated-with-eculizumab
#1
Bénédicte Puissant-Lubrano, Sylvain Puissochet, Nicolas Congy-Jolivet, Dominique Chauveau, Stéphane Decramer, Arnaud Garnier, Antoine Huart, Nassim Kamar, David Ribes, Antoine Blancher
Eculizumab is a monoclonal anti-C5 antibody used in the treatment of atypical hemolytic uremic syndrome (aHUS). We monitored complement inhibition in 16 eculizumab-treated patients suffering from HUS or transplant rejection (not aHUS patients). Blood samples were obtained one to four weeks after the last eculizumab injection. We observed that eculizumab efficiently blocked the terminal pathway (TP) through classical pathway (CP) activation measured by kinetic hemolytic assay (HA) (<10%) but incompletely blocked the TP through alternative pathway (AP) activation measured by rabbit (APH50>23%) or chicken erythrocytes HA (AP100>15%)...
June 21, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28646233/identifying-community-thresholds-for-lotic-benthic-diatoms-in-response-to-human-disturbance
#2
Tao Tang, Ting Tang, Lu Tan, Yuan Gu, Wanxiang Jiang, Qinghua Cai
Although human disturbance indirectly influences lotic assemblages through modifying physical and chemical conditions, identifying thresholds of human disturbance would provide direct evidence for preventing anthropogenic degradation of biological conditions. In the present study, we used data obtained from tributaries of the Three Gorges Reservoir in China to detect effects of human disturbance on streams and to identify disturbance thresholds for benthic diatoms. Diatom species composition was significantly affected by three in-stream stressors including TP, TN and pH...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645750/the-effect-of-future-time-perspective-on-delay-discounting-is-mediated-by-the-gray-matter-volume-of-vmpfc
#3
Yiqun Guo, Zhiyi Chen, Tingyong Feng
Although several previous studies have shown that individuals' attitude towards time could affect their intertemporal preference, little is known about the neural basis of the relation between time perspective (TP) and delay discounting. In the present study, we quantified the gray matter (GM) cortical volume using voxel-based morphometry (VBM) methods to investigate the effect of TP on delay discounting (DD) across two independent samples. For group 1 (102 healthy college students; 46 male; 20.40±1.87 years), behavioral results showed that only Future TP was a significant predictor of DD, and higher scores on Future TP were related to lower discounting rates...
June 20, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28645710/impact-of-upstream-river-inputs-and-reservoir-operation-on-phosphorus-fractions-in-water-particulate-phases-in-the-three-gorges-reservoir
#4
Chaonan Han, Binghui Zheng, Yanwen Qin, Yingqun Ma, Chenchen Yang, Zhichao Liu, Wei Cao, Minghui Chi
The impoundment of the Three Gorges Reservoir (TGR) has changed water-sand transport regime, with inevitable effects on phosphorus transport behavior in the TGR. In this study, we measured phosphorus fractions in water and suspended particles transported from upstream rivers of the TGR (the Yangtze River, the Jialing River and the Wu River) to reservoir inner region over the full operation schedule of the TGR. The aim was to determine how phosphorus fractions in water and particulate phases varied in response to natural hydrological processes and reservoir operations...
June 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28644618/exploring-new-assembly-modes-of-uranyl-terephthalate-templated-syntheses-and-structural-regulation-of-a-series-of-rare-2d-%C3%A2-3d-polycatenated-frameworks
#5
Lei Mei, Cong-Zhi Wang, Liu-Zheng Zhu, Zeng-Qiang Gao, Zhi-Fang Chai, John K Gibson, Wei-Qun Shi
The reaction of uranyl nitrate with terephthalic acid (H2TP) under hydrothermal conditions in the presence of an organic base, 1,3-(4,4'-bispyridyl)propane (BPP) or 4,4'-bipyridine (BPY), provided four uranyl terephthalate compounds with different entangled structures by a pH-tuning method. [UO2(TP)1.5](H2BPP)0.5·2H2O (1) obtained in a relatively acidic solution (final aqueous pH, 4.28) crystallizes in the form of a noninterpenetrated honeycomb-like two-dimensional network structure. An elevation of the solution pH (final pH, 5...
June 23, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28643434/improved-yield-of-minimal-proportional-sample-volume-platelet-bacterial-culture
#6
Hany Kamel, Mary Townsend, Marjorie Bravo, Ralph R Vassallo
BACKGROUND: Reports of septic transfusion reactions (STRs) after transfusion of culture-negative platelets (PLTs) justify more effective prevention strategies. Pathogen reduction technologies or performance of additional point-of-issue testing are proposed strategies to enhance safety through Day 5 of storage. STUDY DESIGN AND METHODS: Trima leukoreduced apheresis PLTs (APs) were collected during two study periods (45 and 31 months) using standard procedures, with target settings adjusted during the second period to maintain split rate after increased culture volume...
June 22, 2017: Transfusion
https://www.readbyqxmd.com/read/28643351/quality-specifications-of-routine-clinical-chemistry-methods-based-on-sigma-metrics-in-performance-evaluation
#7
Jun Xia, Su-Feng Chen, Fei Xu, Yong-Lie Zhou
INTRODUCTION: Sigma metrics were applied to evaluate the performance of 20 routine chemistry assays, and individual quality control criteria were established based on the sigma values of different assays. METHODS: Precisions were expressed as the average coefficient variations (CVs) of long-term two-level chemistry controls. The biases of the 20 assays were obtained from the results of trueness programs organized by National Center for Clinical Laboratories (NCCL, China) in 2016...
June 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28643047/trace-elements-in-pleural-effusion-correlates-with-smokers-with-lung-cancer
#8
Kang-Yun Lee, Po-Hao Feng, Hsiao-Chi Chuang, Sheng-Ming Wu, Wen-Te Liu, Kuan-Yuan Chen, Chien-Ying Liu, Shu-Chuan Ho
Smoking leads to the presence of various elements, including toxic metals and metalloids, in tissues and fluids, thus contributing to cancer risk. This study assessed the concentrations of 14 elements (Ag, Al, As, Co, Cr, Cu, Fe, Ni, Mn, Mo, Pb, Sn, V, and Zn) and biochemical parameters (glucose, lactate dehydrogenase, and total protein) in the pleural effusion (PE) of patients with lung cancer. The potential association of these parameters with smoking was assessed. Total of 48 patients with lung cancer (26 non-smokers and 22 smokers) received thoracocentesis for PE removal...
June 22, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28641811/tension-pneumocephalus-following-suboccipital-sitting-craniotomy-in-the-pediatric-population
#9
P Daszkiewicz, D Dziedzic
BACKGROUND: Sitting craniotomy often results in entrapment of air in fluid-filled intracranial cavities. Gas under pressure exerts a deleterious effect on adjacent nervous tissue, resulting in clinical deterioration. AIM OF STUDY: To assess the incidence of tension pneumocephalus (TP) and to define risk factors associated therewith. MATERIAL AND METHOD: Analysis included 100 consecutive patients (57 boys, 43 girls, mean age 9.7 y) undergoing suboccipital sitting craniotomy since 2012 to 2014...
May 11, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28641229/effects-of-short-term-invasion-of-spartina-alterniflora-and-the-subsequent-restoration-of-native-mangroves-on-the-soil-organic-carbon-nitrogen-and-phosphorus-stock
#10
Jianxiang Feng, Jian Zhou, Liming Wang, Xiaowei Cui, Cunxin Ning, Hao Wu, Xiaoshan Zhu, Guanghui Lin
The exotic cordgrass Spartina alterniflora has severely invaded the mangrove wetlands in southern China and ecological restoration using native mangroves was conducted in an attempt to control this invasive species. In this study, the contents and pools of soil organic carbon (SOC), total nitrogen (TN) and total phosphorus (TP) were quantified to investigate the invasive effects of S. alterniflora and then to evaluate whether the ecological restoration of native mangrove could reverse those effects. S. alterniflora only showed significantly higher organic carbon content in the surface 0-10 cm of soil than in the uninvaded mudflat...
June 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/28637164/biological-nutrient-removal-and-molecular-biological-characteristics-in-an-anaerobic-multistage-anaerobic-oxic-a-mao-process-to-treat-municipal-wastewater
#11
Xiao Huang, Wenyi Dong, Hongjie Wang, Shilong Jiang
This study aimed to present an anaerobic-multistage anaerobic/oxic (A-MAO) process to treat municipal wastewater. The average COD, NH4(+)-N, TN, and TP removal efficiency were 91.81%, 96.26%, 83.73% and 94.49%, respectively. Temperature plunge and C/N decrease have a certain impact on the modified process. Characteristics of microbial community, function microorganism, and correlation of microbial community with environmental variables in five compartments were carried out by Illumina Miseq high-throughput sequencing...
May 29, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28631226/introduction-of-a-simple-second-tier-screening-test-for-c5-isobars-in-dried-blood-spots-reducing-the-false-positive-rate-for-isovaleric-acidaemia-in-expanded-newborn-screening
#12
R S Carling, D Burden, I Hutton, R Randle, K John, J R Bonham
In 2015 the English Newborn Screening programme expanded to include Isovaleric Acidaemia (IVA). Screening is performed by flow injection analysis tandem mass spectrometry of isovalerylcarnitine. Isovalerylcarnitine is isobaric with pivaloylcarnitine which can be present in blood due to the use of pivalic ester pro-drugs or pivalic acid derivatives used as emollients in some nipple creams; the potential for false positives (FP) is well documented. A pilot study in England screened 438,164 babies, 18 had presumptive positive results but only 4 were confirmed as true positives (TP)...
June 20, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28630302/new-perspective-on-spring-vegetation-phenology-and-global-climate-change-based-on-tibetan-plateau-tree-ring-data
#13
Bao Yang, Minhui He, Vladimir Shishov, Ivan Tychkov, Eugene Vaganov, Sergio Rossi, Fredrik Charpentier Ljungqvist, Achim Bräuning, Jussi Grießinger
Phenological responses of vegetation to climate, in particular to the ongoing warming trend, have received much attention. However, divergent results from the analyses of remote sensing data have been obtained for the Tibetan Plateau (TP), the world's largest high-elevation region. This study provides a perspective on vegetation phenology shifts during 1960-2014, gained using an innovative approach based on a well-validated, process-based, tree-ring growth model that is independent of temporal changes in technical properties and image quality of remote sensing products...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28629539/uplc-esi-qtof-ms-based-metabolomics-survey-on-the-toxicity-of-triptolide-and-detoxication-of-licorice
#14
Zhuo Wang, Jian-Qun Liu, Jin-Di Xu, He Zhu, Ming Kong, Guo-Hua Zhang, Su-Min Duan, Xiu-Yang Li, Guang-Fu Li, Li-Fang Liu, Song-Lin Li
Triptolide (TP) from Tripterygium wilfordii has been demonstrated to possess anti-inflammatory, immunosuppressive, and anticancer activities. TP is specially used for the treatment of awkward rheumatoid arthritis, but its clinical application is confined by intense side effects. It is reported that licorice can obviously reduce the toxicity of TP, but the detailed mechanisms involved have not been comprehensively investigated. The current study aimed to explore metabolomics characteristics of the toxic reaction induced by TP and the intervention effect of licorice water extraction (LWE) against such toxicity...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28629364/changes-in-concentrations-of-haemostatic-and-inflammatory-biomarkers-in-synovial-fluid-after-intra-articular-injection-of-lipopolysaccharide-in-horses
#15
Stine Mandrup Andreassen, Anne Mette Lindberg Vinther, Søren Saxmose Nielsen, Pia Haubro Andersen, Aziz Tnibar, Annemarie T Kristensen, Stine Jacobsen
BACKGROUND: Septic arthritis is a common and potentially devastating disease characterized by severe intra-articular (IA) inflammation and fibrin deposition. Research into equine joint pathologies has focused on inflammation, but recent research in humans suggests that both haemostatic and inflammatory pathways are activated in the joint compartment in arthritic conditions. The aim of this study was to characterize the IA haemostatic and inflammatory responses in horses with experimental lipopolysaccharide (LPS)-induced joint inflammation...
June 19, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28628974/the-influence-of-climate-change-on-the-accumulation-of-polycyclic-aromatic-hydrocarbons-black-carbon-and-mercury-in-a-shrinking-remote-lake-of-the-southern-tibetan-plateau
#16
Hai Lin, Xiaoping Wang, Ping Gong, Jiao Ren, Chuanfei Wang, Xiaohua Yuan, Lei Wang, Tandong Yao
A sediment core from a remote lake, Pumoyum Co, located in the southern TP, was analyzed for polycyclic aromatic hydrocarbons (PAHs), black carbon (BC) and mercury. Concentrations ranged from 30 to 229ng/g for PAHs, 0.46 to 1.48mg/g for BC and 10 to 30ng/g for mercury. Significant correlations were found among the concentrations of PAHs, BC and mercury, suggesting the sources of these pollutants to be similar; mainly from combustion processes. Further diagnosis of the likely sources of BC and PAHs suggested that petroleum combustion has been one of the increasing sources in the last few decades, but biomass burning remains the dominant source of these pollutants...
June 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28628943/molecular-antimony-complexes-for-electrocatalysis-activity-of-a-main-group-element-in-proton-reduction
#17
Jianbing Jiang, Kelly Materna, Svante Hedström, Ke Yang, Robert Crabtree, Victor Batista, Gary Brudvig
Main group complexes are shown to be viable electrocatalysts for the H2-evolution reaction (HER) from acid. A series of antimony porphyrins with varying axial ligands were synthesized for electrocatalysis applications. The proton-reduction catalytic properties of the compound TPSb(OH)2 (TP = 5,10,15,20-tetra(p-tolyl)porphyrin) with two hydroxyl axial ligands was studied in detail, demonstrating catalytic H2 production. Experiments, in conjunction with quantum chemistry calculations, show that the catalytic cycle is driven via the redox activity of both the porphyrin ligand and the Sb center...
June 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28628812/modelling-water-and-nutrient-fluxes-in-the-danube-river-basin-with-swat
#18
REVIEW
Anna Malagó, Faycal Bouraoui, Olga Vigiak, Bruna Grizzetti, Marco Pastori
This study provides an innovative process-based modelling approach using the SWAT model and shows its application to support the implementation of the European environmental policies in large river basins. The approach involves several pioneering modelling aspects: the inclusion of current management practices; an innovative calibration and validation methodology of streamflow and water quality; a sequential calibration starting from crop yields, followed by streamflow and nutrients; and the use of concentrations instead of loads in the calibration...
June 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28625655/a-randomized-controlled-trial-comparing-indwelling-pleural-catheters-with-talc-pleurodesis-nvalt-14
#19
R C Boshuizen, V Vd Noort, J A Burgers, G J M Herder, S M S Hashemi, T J N Hiltermann, P W Kunst, J A Stigt, M M van den Heuvel
BACKGROUND: Symptomatic malignant pleural effusion (MPE) occurs frequently in patients with metastatic cancer. The associated prognosis is poor and the success rate of talc pleurodesis (TP) is low. Indwelling pleural catheters (IPCs) are commonly inserted when TP has been unsuccessful. METHODS: We compared talc pleurodesis with the use of an indwelling pleural catheter in patients with recurrent MPE in a multicenter randomized controlled trial (superiority design)...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28625256/-comparison-of-effect-of-norepinephrine-and-terlipressin-on-patients-with-ards-combined-with-septic-shock-a-prospective-single-blind-randomized-controlled-trial
#20
Zhi Chen, Ping Zhou, Yuanhua Lu, Chunli Yang
OBJECTIVE: To approach the effect of different vasopressor on hemodynamics, volume responsiveness, fluid volume balance, renal function and prognosis in patients with acute respiratory distress syndrome (ARDS) complicated with septic shock. METHODS: A prospective single-blind randomized controlled trial was conducted. ARDS patients with septic shock admitted to the Department of Critical Care Medicine of Jiangxi Provincial People's Hospital from January 1st, 2015 to May 1st, 2016 were enrolled...
February 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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