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https://www.readbyqxmd.com/read/28819105/a-novel-method-for-genome-wide-profiling-of-dynamic-host-pathogen-interactions-using-3-end-enriched-rna-seq
#1
Jie Li, Liangliang He, Yun Zhang, Chunyi Xue, Yongchang Cao
Marek's disease is a contagious lymphoproliferative disease of chickens and typical model of viral oncogenesis. Mapping changes or different states over the course of infection for both host and pathogen would provide important insights into dynamic host-pathogen interactions. Here we introduced 3' end enriched RNA-seq as a novel method to study host-pathogen interactions in chicken embryo fibroblasts cells challenged with Marek's disease virus. The method allowed accurate profiling of gene expression and alternative polyadenylation sites for host and pathogen simultaneously...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762757/molecular-characterization-and-phylogenetic-analysis-of-virulent-marek-s-disease-virus-field-strain-in-broiler-chickens-in-japan
#2
Hoda A Abd-Ellatieff, Abdelrahman A Abou Rawash, Hany F Ellakany, Wael M Goda, T Suzuki, Tokuma Yanai
Marek's disease (MD) is a lymphoproliferative disease causing a serious threat in poultry production. Field strains of Marek's disease virus (MDVs) are continuously re-emerging, causing great economical losses to the poultry industry worldwide in spite of the intensive vaccination and restrictive management policy used. Histopathological and molecular characterizations of MDVs are essential for monitoring the changes of viruses and evaluating the effectiveness of existing vaccines. During 2016, 190 visceral tumor tissues representing 30 vaccinated chicken flocks from Gifu prefecture, Japan were analyzed...
August 1, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28757026/marek-s-disease-virus-type-1-encoded-analog-of-mir-155-promotes-proliferation-of-chicken-embryo-fibroblast-and-df-1-cells-by-targeting-hnrnpab
#3
Lu Dang, Man Teng, Hui-Zhen Li, Sheng-Ming Ma, Qing-Xia Lu, Hui-Fang Hao, Dong Zhao, En-Min Zhou, Gai-Ping Zhang, Jun Luo
Marek's disease virus type 1 (MDV-1) is a representative oncogenic Alpha herpesvirus that causes an immunosuppressive and neoplastic lymphoproliferative avian disease, namely Marek's disease (MD). The rapid-onset T-cell lymphoma in chickens induced by MDV-1 has been historically regarded as an ideal natural model for herpesvirus-related cancer research. As a viral analog of cellular miR-155, the MDV-1-encoded miR-M4-5p has been shown to be crucial for the virally-induced MD tumorigenesis. Our previous studies demonstrated that miR-M4-5p induces an over-expression of oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway during MDV-1 infection...
August 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28711655/ubiquitination-at-the-mitochondria-in-neuronal-health-and-disease
#4
REVIEW
Christian Covill-Cooke, Jack Howden, Nicol Birsa, Josef Kittler
The preservation of mitochondrial function is of particular importance in neurons given the high energy requirements of action potential propagation and synaptic transmission. Indeed, disruptions in mitochondrial dynamics and quality control are linked to cellular pathology in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Here, we will discuss the role of ubiquitination by the E3 ligases: Parkin, MARCH5 and Mul1, and how they regulate mitochondrial homeostasis. Furthermore, given the role of Parkin and Mul1 in the formation of mitochondria-derived vesicles we give an overview of this area of mitochondrial homeostasis...
July 12, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28677643/telomeres-and-telomerase-role-in-marek-s-disease-virus-pathogenesis-integration-and-tumorigenesis
#5
REVIEW
Ahmed Kheimar, Renato L Previdelli, Darren J Wight, Benedikt B Kaufer
Telomeres protect the ends of vertebrate chromosomes from deterioration and consist of tandem nucleotide repeats (TTAGGG)n that are associated with a number of proteins. Shortening of the telomeres occurs during genome replication, thereby limiting the replication potential of somatic cells. To counteract this shortening, vertebrates encode the telomerase complex that maintains telomere length in certain cell types via de novo addition of telomeric repeats. Several herpesviruses, including the highly oncogenic alphaherpesvirus Marek's disease virus (MDV), harbor telomeric repeats (TMR) identical to the host telomere sequences at the ends of their linear genomes...
July 4, 2017: Viruses
https://www.readbyqxmd.com/read/28652615/gga-mir-219b-targeting-bcl11b-suppresses-proliferation-migration-and-invasion-of-marek-s-disease-tumor-cell-msb1
#6
Chunfang Zhao, Xin Li, Bo Han, Zhen You, Lujiang Qu, Changjun Liu, Jiuzhou Song, Ling Lian, Ning Yang
Marek's disease (MD), caused by Marek's disease virus (MDV), is a lymphotropic neoplastic disease. Previous miRNAome analysis showed gga-miR-219b was significantly downregulated in MDV-induced lymphoma, and one of its potential target genes, B-cell chronic lymphocytic /lymphoma 11B (BCL11B) was predicted. In this study, we further investigated the function of gga-miR-219b, and the gain/loss of function assay showed gga-miR-219b inhibited cell migration and reduced cell proliferation by promoting apoptosis not by cell cycle arrest...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28635675/co-infection-with-marek-s-disease-virus-and-reticuloendotheliosis-virus-increases-illness-severity-and-reduces-marek-s-disease-vaccine-efficacy
#7
Guo-Rong Sun, Yan-Ping Zhang, Lin-Yi Zhou, Hong-Chao Lv, Feng Zhang, Kai Li, Yu-Long Gao, Xiao-Le Qi, Hong-Yu Cui, Yong-Qiang Wang, Li Gao, Qing Pan, Xiao-Mei Wang, Chang-Jun Liu
Marek's disease virus (MDV) and reticuloendotheliosis virus (REV) cause Marek's disease (MD) and reticuloendotheliosis (RE), respectively. Co-infection with MDV and REV is common in chickens, causing serious losses to the poultry industry. However, experimental studies of such co-infection are lacking. In this study, Chinese field strains of MDV (ZW/15) and REV (JLR1501) were used as challenge viruses to evaluate the pathogenicity of co-infection and the influence of MD vaccination in chickens. Compared to the MDV-challenged group, the mortality and tumor rates increased significantly by 20...
June 21, 2017: Viruses
https://www.readbyqxmd.com/read/28591220/comparative-transcriptomics-of-genetically-divergent-lines-of-chickens-in-response-to-marek-s-disease-virus-challenge-at-cytolytic-phase
#8
Kunzhe Dong, Shuang Chang, Qingmei Xie, Alexis Black-Pyrkosz, Huanmin Zhang
Marek's disease (MD), caused by Marek's disease virus (MDV), remains an economically significant threat to the poultry industry worldwide. Genetic resistance to MD is a promising alternative strategy to augment current control measures (vaccination and management). However, only a few functional genes reportedly conferring MD resistance have been identified. Here, we performed a comparative transcriptomics analysis of two highly inbred yet genetically divergent lines of chickens (line 63 and 72) that are resistant and susceptible to MD, respectively, in response to a very virulent plus strain of MDV (vv+MDV) challenge at cytolytic phase...
2017: PloS One
https://www.readbyqxmd.com/read/28548038/marek-s-disease-virus-infection-of-phagocytes-a-de-novo-in-vitro-infection-model
#9
Pankaj Chakraborty, Lonneke Vervelde, Robert G Dalziel, Peter S Wasson, Venugopal Nair, Bernadette M Dutia, Pete Kaiser
Marek's disease virus (MDV) is an alphaherpesvirus that induces T-cell lymphomas in chickens. Natural infections in vivo are caused by the inhalation of infected poultry house dust and it is presumed that MDV infection is initiated in the macrophages from where the infection is passed to B cells and activated T cells. Virus can be detected in B and T cells and macrophages in vivo, and both B and T cells can be infected in vitro. However, attempts to infect macrophages in vitro have not been successful. The aim of this study was to develop a model for infecting phagocytes [macrophages and dendritic cells (DCs)] with MDV in vitro and to characterize the infected cells...
May 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28543018/multiple-ice-binding-proteins-of-probable-prokaryotic-origin-in-an-antarctic-lake-alga-chlamydomonas-sp-ice-mdv-chlorophyceae
#10
James A Raymond, Rachael Morgan-Kiss
Ice-associated algae produce ice-binding proteins (IBPs) to prevent freezing damage. The IBPs of the three chlorophytes that have been examined so far share little similarity across species, making it likely that they were acquired by horizontal gene transfer (HGT). To clarify the importance and source of IBPs in chlorophytes, we sequenced the IBP genes of another Antarctic chlorophyte, Chlamydomonas sp. ICE-MDV (Chlamy-ICE). Genomic DNA and total RNA were sequenced and screened for known ice-associated genes...
August 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28535864/sterility-and-stability-of-diluted-carprofen-in-a-multidose-vial-in-the-laboratory-animal-setting
#11
Gregory D Simonek, Gwendolyne G Alarcio, Laurie L Brignolo
Using compounded multidose vials (cMDV) is a common practice in the laboratory animal setting, where medications often are diluted to provide appropriate doses to rodents. However, bacterial contamination of MDV has been well established in both the human and veterinary medical literature. For this study, we created 14 cMDV by diluting carprofen into sterile water (dilution, 1:10) and stored 6 cMDV each at 5 and 24 °C. The stoppers of the cMDV were not cleaned with alcohol, and all were punctured twice daily for 28 d...
May 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28534093/quality-of-life-among-perinatally-hiv-affected-and-hiv-unaffected-school-aged-and-adolescent-ugandan-children-a-multi-dimensional-assessment-of-wellbeing-in-the-post-haart-era
#12
A K Nkwata, S K Zalwango, F N Kizza, J N Sekandi, J Mutanga, M Zhang, P M Musoke, A E Ezeamama
OBJECTIVE: To examine quality of life (QOL) in perinatally HIV-infected (PHIV) or HIV-exposed uninfected (PHEU) vs. healthy HIV-unexposed uninfected (HUU) children during school-age/adolescence. METHODS: PHIV infection was diagnosed via DNA PCR. Current HIV status was confirmed by HIV rapid diagnostic test. Three HIV groups were defined: PHIV, PHEU, and HUU. QOL was assessed with proxy and self-report versions of the PedsQL™ 4.0 instrument at 6-18 years of age...
May 22, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28532188/differential-amplification-of-marek-s-disease-cvi988-vaccine-and-of-wild-type-isolates-from-organs-of-commercial-chickens-using-single-or-duplexed-probes-in-real-time-pcr
#13
Irit Davidson, Amira Natour-Altoury, Israel Raibstein, Yaad Dahan
The DIVA test, based on the MDV pp38 gene was described by Baigent et al. (2016), using similar primers and alternate probes for virulent MDV-1 and the vaccine CVI988 virus. We now explored the assay applicability for commercial vaccines and for DNAs of commercial chickens, as former study employed tissue cultured prototype MDV strains and chicken tissue from experimental infection trials. DNA of chicken visceral organs and feathers of either vaccinated, or naturally-infected with virulent MDV-1 wild-type viruses was used for DIVA-PCR real-time PCR...
May 22, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28528445/interindividual-spread-of-herpesviruses
#14
Keith W Jarosinski
Interindividual spread of herpesviruses is essential for the virus life cycle and maintenance in host populations. For most herpesviruses, the virus-host relationship is close, having coevolved over millions of years resulting in comparatively high species specificity. The mechanisms governing interindividual spread or horizontal transmission are very complex, involving conserved herpesviral and cellular proteins during the attachment, entry, replication, and egress processes of infection. Also likely, specific herpesviruses have evolved unique viral and cellular interactions during cospeciation that are dependent on their relationship...
2017: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/28479175/immunogenicity-and-safety-of-13-valent-pneumococcal-conjugate-vaccine-pcv13-formulated-with-2-phenoxyethanol-in-multidose-vials-given-with-routine-vaccination-in-healthy-infants-an-open-label-randomized-controlled-trial
#15
Olubukola T Idoko, Robert B Mboizi, Michael Okoye, France Laudat, Bubacarr Ceesay, John Z Liang, Natacha Le Dren-Narayanin, Kathrin U Jansen, Alejandra Gurtman, Kimberly J Center, Daniel A Scott, Beate Kampmann, Anna Roca
BACKGROUND: This open-label randomized controlled trial in infants compared safety, tolerability, and immunogenicity of the 13-valent pneumococcal conjugate vaccine (PCV13) formulated with the preservative 2-phenoxyethanol (2-PE) in a multidose vial (MDV) to the current PCV13 without 2-PE in a single-dose syringe (SDS). METHODS: Gambian infants were randomized 1:1 to receive PCV13 as either MDV or SDS at ages 2, 3, and 4months. Serotype-specific antipneumococcal antibody responses and opsonophagocytic activity ([OPA]; subset) were measured at age 5months...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28475033/differentially-expressed-genes-during-spontaneous-lytic-switch-of-marek-s-disease-virus-in-lymphoblastoid-cell-lines-determined-by-global-gene-expression-profiling
#16
William N Mwangi, Deepali Vasoya, Lydia B Kgosana, Mick Watson, Venugopal Nair
Marek's disease virus (MDV), an alphaherpesvirus of poultry, causes Marek's disease and is characterized by visceral CD4+TCRαβ+ T-cell lymphomas in susceptible hosts. Immortal cell lines harbouring the viral genome have been generated from ex vivo cultures of MD tumours. As readily available sources of large numbers of cells, MDV-transformed lymphoblastoid cell lines (LCLs) are extremely valuable for studies of virus-host interaction. While the viral genome in most cells is held in a latent state, minor populations of cells display spontaneous reactivation identifiable by the expression of lytic viral genes...
April 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28453957/a-magnetic-droplet-vaporization-approach-using-perfluorohexane-encapsulated-magnetic-mesoporous-particles-for-ultrasound-imaging-and-tumor-ablation
#17
Zhaogang Teng, Ronghui Wang, Yang Zhou, Michael Kolios, Yanjie Wang, Nan Zhang, Zhigang Wang, Yuanyi Zheng, Guangming Lu
Phase change agents consisting of low boiling point perfluorocarbon (PFC) compounds have attracted increasing attention for ultrasound contrast-enhanced imaging and tumor therapy. However, the refraction, acoustic shadowing, reverberation, or limited penetration depth hamper their practical applications through previously reported acoustic droplet vaporization (ADV) or optical droplet vaporization (ODV) technique. Herein, we demonstrate a magnetic droplet vaporization (MDV) approach by loading perflurohexane (PFH) in magnetic mesoporous particles with a hollow space to carry out ultrasound imaging and tumor ablation...
April 15, 2017: Biomaterials
https://www.readbyqxmd.com/read/28425390/sterility-and-stability-of-diluted-carprofen-in-a-multidose-vial-in-the-laboratory-animal-setting
#18
Gregory D Simonek Gwendolyne G Alarcio And Laurie L Brignolo
Using compounded multidose vials (cMDV) is a common practice in the laboratory animal setting, where medications oftenare diluted to provide appropriate doses to rodents. However, bacterial contamination of MDV has been well establishedin both the human and veterinary medical literature. For this study, we created 14 cMDV by diluting carprofen into sterilewater (dilution, 1:10) and stored 6 cMDV each at 5 and 24 °C. The stoppers of the cMDV were not cleaned with alcohol, andall were punctured twice daily for 28 d...
April 19, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28413051/protective-efficacy-of-a-novel-recombinant-marek-s-disease-virus-vector-vaccine-against-infectious-bursal-disease-in-chickens-with-or-without-maternal-antibodies
#19
Kai Li, Yongzhen Liu, Yanping Zhang, Li Gao, Changjun Liu, Hongyu Cui, Xiaole Qi, Yulong Gao, Li Zhong, Xiaomei Wang
Infectious bursal disease (IBD) causes significant clinical and economic losses to the poultry industry worldwide. Current vaccine programs using live attenuated and inactivated vaccines have numerous drawbacks. As an alternative solution to control IBD, a Marek's disease virus (MDV) vector vaccine (rMDV-VP2) expressing the VP2 gene of infectious bursal disease virus (IBDV) has been developed. In this study, the protective efficacy of rMDV-VP2 was evaluated in a dose-related experiment which showed that a single dose of 1000 PFU was sufficient to fully protect chickens against IBDV infection...
April 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28410454/transcriptomic-analysis-of-host-immune-response-in-the-skin-of-chickens-infected-with-marek-s-disease-virus
#20
Mohammad Heidari, Phillip C Delekta
Marek's disease virus (MDV), a highly cell-associated oncogenic α-herpesvirus, is the causative agent of T cell lymphoma and neuropathic disease called Marek's disease. The skin is the only anatomical site where infectious enveloped cell-free virions are produced and shed into the environment. Studies have demonstrated that MDV infection induces immunological responses within the skin, including the release of cytokines and the recruitment of T lymphocytes. The host immune response, however, is not sufficient to block replication and shedding of the virus particles from the skin...
June 2017: Viral Immunology
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