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https://www.readbyqxmd.com/read/29423087/design-of-mirna-sponges-for-mdv-1-as-a-therapeutic-strategy-against-lymphomas
#1
Yuan Fang, Yuqi Zhou, Yun Zhang, Liangliang He, Chunyi Xue, Yongchang Cao
Lymphomas are solid-type tumors containing lymphoid cells. Some of latent herpesvirus infections established in B and/or T-lymphocytes could result in the formation of lymphomas. Marek's disease virus serotype 1 (MDV-1) is an avian herpes virus causing to lymphoproliferative tumors in birds, known as Marek's disease (MD). MD has often been used as an ideal biological model for studying the pathogenesis of lymphoma diseases caused by viruses. Therefore, we used it as a research subject to study the effect of miRNA sponges on its tumorigenicity, and to develop the theoretical basis for a new anti-tumor small molecule...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29407380/attenuation-of-marek-s-disease-virus-by-codon-pair-deoptimization-of-a-core-gene
#2
Steven J Conrad, Robert F Silva, Cari J Hearn, Megan Climans, John R Dunn
Marek's disease virus (MDV) is an oncogenic alphaherpesvirus of Gallus gallus, the domesticated chicken. Control strategies rely upon vaccination with live attenuated viruses of antigenically similar avian herpesviruses or attenuated strains of MDV. Recent studies in other viruses have shown that recoding certain viral genes to employ synonymous but rarely-used codon pairs resulted in viral attenuation. We deoptimized two MDV proteins, UL54/ICP27 and UL49/VP22, and demonstrate that the more severely deoptimized variant of UL54 accumulates significantly less gene product in vitro...
February 1, 2018: Virology
https://www.readbyqxmd.com/read/29407378/phylogenetic-and-molecular-epidemiological-studies-reveal-evidence-of-recombination-among-marek-s-disease-viruses
#3
Liangliang He, Jie Li, Yun Zhang, Jun Luo, Yongchang Cao, Chunyi Xue
Marek's disease has brought enormous loss in chicken production worldwide and the increasing virulence of Marek's disease virus (MDV) became a severe problem. To better understand the genetic basis underlying, a Chinese MDV strain HNGS101 isolated from immunized chickens was sequenced. Phylogenetic analysis implied that HNGS101 showed more relatedness to Eurasian strains than GaHV-2 circulating in North America. Recombination networks analysis showed the evidence of recombination among MDV strains, and several recombination events in the UL and US region were found...
January 31, 2018: Virology
https://www.readbyqxmd.com/read/29377958/attenuation-of-a-very-virulent-marek-s-disease-herpesvirus-mdv-by-codon-pair-bias-deoptimization
#4
Kathrin Eschke, Jakob Trimpert, Nikolaus Osterrieder, Dusan Kunec
Codon pair bias deoptimization (CPBD) has enabled highly efficient and rapid attenuation of RNA viruses. The technique relies on recoding of viral genes by increasing the number of codon pairs that are statistically underrepresented in protein coding genes of the viral host without changing the amino acid sequence of the encoded proteins. Utilization of naturally underrepresented codon pairs reduces protein production of recoded genes and directly causes virus attenuation. As a result, the mutant virus is antigenically identical with the parental virus, but virulence is reduced or absent...
January 29, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29366873/modeling-marek-s-disease-virus-transmission-a-framework-for-evaluating-the-impact-of-farming-practices-and-evolution
#5
David A Kennedy, Patricia A Dunn, Andrew F Read
Marek's disease virus (MDV) is a pathogen of chickens whose control has twice been undermined by pathogen evolution. Disease ecology is believed to be the main driver of this evolution, yet mathematical models of MDV disease ecology have never been confronted with data to test their reliability. Here, we develop a suite of MDV models that differ in the ecological mechanisms they include. We fit these models with maximum likelihood using iterated filtering in 'pomp' to data on MDV concentration in dust collected from two commercial broiler farms...
January 10, 2018: Epidemics
https://www.readbyqxmd.com/read/29331866/development-of-a-novel-equine-influenza-virus-live-attenuated-vaccine
#6
Laura Rodriguez, Stephanie Reedy, Aitor Nogales, Pablo R Murcia, Thomas M Chambers, Luis Martinez-Sobrido
H3N8 equine influenza virus (EIV) is an important and significant respiratory pathogen of horses. EIV is enzootic in Europe and North America, mainly due to the suboptimal efficacy of current vaccines. We describe, for the first time, the generation of a temperature sensitive (ts) H3N8 EIV live-attenuated influenza vaccine (LAIV) using reverse-genetics approaches. Our EIV LAIV was attenuated (att) in vivo and able to induce, upon a single intranasal administration, protection against H3N8 EIV wild-type (WT) challenge in both a mouse model and the natural host, the horse...
January 11, 2018: Virology
https://www.readbyqxmd.com/read/29317752/epstein-barr-virus-encoded-rnas-ebers-complement-the-loss-of-herpesvirus-telomerase-rna-vtr-in-virus-induced-tumor-formation
#7
Ahmed Kheimar, Benedikt B Kaufer
Marek's disease virus (MDV) is an alphaherpesvirus that causes fatal lymphomas in chickens and is used as a natural virus-host model for herpesvirus-induced tumorigenesis. MDV encodes a telomerase RNA subunit (vTR) that is crucial for efficient MDV-induced lymphoma formation; however, the mechanism is not completely understood. Similarly, Epstein Barr-virus (EBV) encodes two RNAs (EBER-1 and EBER-2) that are highly expressed in EBV-induced tumor cells, however their role in tumorigenesis remains unclear. Intriguingly, vTR and EBER-1 have interaction partners in common that are highly conserved in humans and chickens...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29249067/detection-of-angiographically-significant-coronary-obstruction-using-resting-transthoracic-coronary-doppler-echocardiography
#8
Alberto Cozzarin, Gerardo Manuel Marambio, Daniel Ernesto Ferreiro, Maria Fernanda Gonda, Lorena Romina Balletti, Martin Hernán Medawar, Juan Alberto Gagliardi, Tomás Francisco Cianciulli
BACKGROUND: Transesophageal Doppler echocardiography has shown that significant stenosis can be detected based on the presence of aliasing with color Doppler in the stenotic area. The study aimed to assess the detection of angiographically significant coronary stenosis (ASCS) by analyzing the characteristics and velocities of resting coronary artery flow (RCF) using transthoracic coronary Doppler echocardiography (TCDE). METHODS: TCDE was performed before diagnostic coronary angiography (CA)...
December 16, 2017: Journal of Echocardiography
https://www.readbyqxmd.com/read/29151863/a-phylogenomic-analysis-of-marek-s-disease-virus-reveals-independent-paths-to-virulence-in-eurasia-and-north-america
#9
Jakob Trimpert, Nicole Groenke, Maria Jenckel, Shulin He, Dusan Kunec, Moriah L Szpara, Stephen J Spatz, Nikolaus Osterrieder, Dino P McMahon
Virulence determines the impact a pathogen has on the fitness of its host, yet current understanding of the evolutionary origins and causes of virulence of many pathogens is surprisingly incomplete. Here, we explore the evolution of Marek's disease virus (MDV), a herpesvirus commonly afflicting chickens and rarely other avian species. The history of MDV in the 20th century represents an important case study in the evolution of virulence. The severity of MDV infection in chickens has been rising steadily since the adoption of intensive farming techniques and vaccination programs in the 1950s and 1970s, respectively...
December 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/29091922/characterization-of-the-deubiquitination-activity-and-substrate-specificity-of-the-chicken-ubiquitin-specific-protease-1-usp-associated-factor-1-complex
#10
Hainan Zheng, Mengyun Wang, Chengcheng Zhao, Shanli Wu, Peifeng Yu, Yan Lü, Tiedong Wang, Yongxing Ai
Deubiquitinases (DUBs) are essential regulators of intracellular processes involving ubiquitin (Ub) modification. The human DUB ubiquitin-specific protease 1 (hUSP1) interacts with human USP-associated factor 1 (hUAF1), and helps to regulate processes such as DNA damage repair. Previously, we identified a chicken USP1 homologue (chUSP1) during an investigation into the properties of Marek's disease virus (MDV). However, chUSP1's deubiquitination activity, interaction with chUAF1, and substrate specificity remained unknown...
2017: PloS One
https://www.readbyqxmd.com/read/29053694/use-of-a-recombinant-mosquito-densovirus-as-a-gene-delivery-vector-for-the-functional-analysis-of-genes-in-mosquito-larvae
#11
Pei-Wen Liu, Jia-Bao Xu, Yun-Qiao Dong, Xiao-Guang Chen, Jin-Bao Gu
In vivo microinjection is the most commonly used gene transfer technique for analyzing the gene functions in individual mosquitoes. However, this method requires a more technically demanding operation and involves complicated procedures, especially when used in larvae due to their small size, relatively thin and fragile cuticle, and high mortality, which limit its application. In contrast, viral vectors for gene delivery have been developed to surmount extracellular and intracellular barriers. These systems have the advantages of easy manipulation, high gene transduction efficiency, long-term maintenance of gene expression, and the ability to produce persistent effects in vivo...
October 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29050325/toll-like-receptor-3-pathway-restricts-marek-s-disease-virus-infection
#12
Haitao Zou, Ruixue Su, Jing Ruan, Hongxia Shao, Kun Qian, Jianqiang Ye, Aijian Qin
Marek's disease virus (MDV) is an α-herpesvirus that causes immune suppression and T lymphoma in chickens. Toll-like receptor 3 (TLR3) is critical for the host immune response against MDV infection. Previously, our team demonstrated that pre-treatment of TLR3 agonist poly (I:C) inhibited Marek's disease virus infection in chicken embryo fibroblasts (CEFs). However, whether TLR3 inhibits the aggravation of MDV infection is unknown. In the current study, we found that TLR3 activation in MDV-infected CEFs effectively inhibited virus spread...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29046542/decadal-ecosystem-response-to-an-anomalous-melt-season-in-a-polar-desert-in-antarctica
#13
Michael N Gooseff, John E Barrett, Byron J Adams, Peter T Doran, Andrew G Fountain, W Berry Lyons, Diane M McKnight, John C Priscu, Eric R Sokol, Cristina Takacs-Vesbach, Martijn L Vandegehuchte, Ross A Virginia, Diana H Wall
Amplified climate change in polar regions is significantly altering regional ecosystems, yet there are few long-term records documenting these responses. The McMurdo Dry Valleys (MDV) cold desert ecosystem is the largest ice-free area of Antarctica, comprising soils, glaciers, meltwater streams and permanently ice-covered lakes. Multi-decadal records indicate that the MDV exhibited a distinct ecosystem response to an uncharacteristic austral summer and ensuing climatic shift. A decadal summer cooling phase ended in 2002 with intense glacial melt ('flood year')-a step-change in water availability triggering distinct changes in the ecosystem...
September 2017: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29018431/depression-of-vaccinal-immunity-to-marek-s-disease-by-infection-with-chicken-infectious-anemia-virus
#14
Yankun Zhang, Ning Cui, Ni Han, Jiayan Wu, Zhizhong Cui, Shuai Su
Marek's disease (MD) has been occurring with increasing frequency in chickens in recent years. To our knowledge, however, there has been no report of the very virulent plus (vv+) MD virus (MDV) field isolate in China. Studies have shown that dual infection with immunosuppressive viruses such as chicken infectious anemia virus (CIAV) occurs frequently in chickens developing MD. In this study, we performed a designed set of in vivo experiments, which comprised five different groups of chickens, including the group of CVI988/Rispens-vaccinated chickens, the groups of CVI988/Rispens-vaccinated chickens infected with MDV or CIAV or both viruses (MDV and CIAV), and the group of MDV-challenged chickens...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28978699/induction-of-dna-damages-upon-marek-s-disease-virus-infection-implication-in-viral-replication-and-pathogenesis
#15
Djihad Bencherit, Sylvie Remy, Yves Le Vern, Tereza Vychodil, Luca D Bertzbach, Benedikt B Kaufer, Caroline Denesvre, Laëtitia Trapp-Fragnet
Marek's disease virus (MDV) is a highly contagious alphaherpesvirus that infects chickens and causes a deadly neoplastic disease. We previously demonstrated that MDV infection arrests cells in S-phase and that the tegument protein VP22 plays a major role in this process. In addition, expression of VP22 induces double strand breaks (DSB) in the cellular DNA, suggesting that DNA damage and the associated cellular response might be favorable for the MDV lifecycle. Here, we addressed the role of DNA damage in MDV replication and pathogenesis...
October 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28952224/increased-expression-of-platelet-derived-growth-factor-receptor-%C3%AE-on-trephine-biopsies-correlates-with-advanced-myeloma
#16
Antonios Bilalis, Evi Pouliou, Maria Roussou, Asimina Papanikolaou, Anna Tassidou, Theophanis Economopoulos, Evangelos Terpos
PURPOSE: Multiple myeloma (MM), a major cause of cancer mortality, is considered the second most frequent haematological malignancy in Europe. Angiogenesis is a multifactorial process that drives the tumorigenesis in solid tumors and in MM. The platelet derived growth factor (PDGF) receptors are cell surface tyrosine kinase receptors and play an important role in angiogenesis, cancer cell proliferation and dissemination. Few studies have been conducted regarding the expression of PDGF receptors and the correlation with clinical-pathological parameters and prognosis in MM...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28952221/research-of-the-effect-of-mir-663-on-the-proliferation-of-prostate-cancer-cells-and-the-correlations-of-mir-663-with-pathological-grade-and-clinical-stage
#17
Shifeng Wang, Jingsong Liu, Changming Li, Xue Yang
PURPOSE: To investigate the effect of miR-663 on the proliferation of prostate cancer (PCa) cells, and the correlations of miR-663 with pathological grade and clinical stage. METHODS: PC-3 and DU-145 PCa cell lines were transfected by artificially synthesized miR-663 and its antisense plasmid, and cell proliferation was assessed using 5-ethynyl-2'-deoxyuridine and methyl thiazolyl tetrazolium assays. Real-time polymerase chain reaction (RT-PCR) was applied to assess the expression of miR-663 in tissue samples collected from 46 patients who were diagnosed with PCa but did not receive any treatment...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28925077/network-wide-screen-identifies-variation-of-novel-precise-on-module-targets-using-conformational-modudaoism
#18
Bing Li, Jun Liu, Yanan Yu, Pengqian Wang, Yingying Zhang, Xumin Ni, Qiong Liu, Xiaoxu Zhang, Zhong Wang, Yongyan Wang
Modular targeting is promising in drug research at network level, but it's challenging to quantificationally identify the precise On-modules. Based on a proposed Modudaoism (MD), we defined conserved MD (MDc) and varied MD (MDv) to quantitatively evaluate the conformational and energy variations of modules, and thereby identify the conserved and discrepant allosteric modules. Compared with the Zsummary , MDc/MDv got an optimized result of module preserved ratio and modular structure. In mice anti-ischemic networks, 3, 5, and 1 conserved allosteric modules as well as 4, 1, and 3 On-modules of baicalin (BA), jasminoidin (JA), and ursodeoxycholic acid (UA) were identified by MDc and MDv, 5 unique allosteric modules and their characteristic actions were revealed...
September 19, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28860661/long-intergenic-non-coding-rna-galmd3-in-chicken-marek-s-disease
#19
Bo Han, Yanghua He, Li Zhang, Yi Ding, Ling Lian, Chunfang Zhao, Jiuzhou Song, Ning Yang
Long intergenic non-coding RNAs (lincRNAs) are transcribed from non-coding DNA sequences. Studies have revealed that aberrant expressions of lincRNAs are associated with various types of cancers and neurological disorders. Marek's disease (MD) is a highly contagious T-cell lymphoid neoplasia of chicken induced by Marek's disease virus (MDV). In this study, we first identified and validated linc-GALMD3 highly expressed in MDV-infected CD4+ T cells by RNA-Seq and qRT-PCR. By RNA-Seq analysis in MDCC-MSB1 cells after loss of function of linc-GALMD3 by shRNA, we found that linc-GALMD3 could positively cis-regulate its downstream gga-miR-223 gene expression...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28859493/characterizing-the-histopathology-of-natural-co-infection-with-marek-s-disease-virus-and-subgroup-j-avian-leukosis-virus-in-egg-laying-hens
#20
Yawen Wen, Qi Huang, Chengcheng Yang, Ling Pan, Guijun Wang, Kezong Qi, Hongmei Liu
Marek's disease virus (MDV) and avian leukosis virus (ALV) are known to cause tumours in egg-laying hens. Here, we investigated the aetiology of tumours in a flock of egg-laying hens vaccinated against MDV. We carried out gross pathology and histopathological examinations of the diseased tissues, identified virus antigen and sequenced viral oncogenes to elucidate the cause of death in 21-22-wk-old hens. At necropsy, diseased hens had distinctly swollen livers, spleens, and proventriculus, and white tumour nodules in the liver...
September 1, 2017: Avian Pathology: Journal of the W.V.P.A
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