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https://www.readbyqxmd.com/read/29917121/new-insights-into-spinal-cord-ischaemia-after-thoracic-aortic-procedures-the-importance-of-the-number-of-anterior-radiculomedullary-arteries-for-surgical-outcome
#1
Fabian A Kari, Babak Saravi, Sonja Krause, Luisa Puttfarcken, Johannes Scheumann, Katharina Förster, Bartosz Rylski, Sven Maier, Ulrich Göbel, Matthias Siepe, Martin Czerny, Friedhelm Beyersdorf
OBJECTIVES: Anterior radiculomedullary arteries (ARMAs) link dorsal segmental arteries and the intraspinal compartment of the spinal collateral network. The number of thoracic ARMA is highly variable from one person to another. The impact of the number of ARMAs on spinal cord perfusion during thoracic aortic procedures is unknown. We investigated the influence of the number of thoracic ARMAs on spinal cord perfusion in an aortic surgical large animal model. METHODS: Twenty-six pigs were included (20 treatment animals, 6 sham animals, weight 34 ± 3 kg)...
July 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29917119/novel-common-genetic-susceptibility-loci-for-colorectal-cancer
#2
Stephanie L Schmit, Christopher K Edlund, Fredrick R Schumacher, Jian Gong, Tabitha A Harrison, Jeroen R Huyghe, Chenxu Qu, Marilena Melas, David J Van Den Berg, Hansong Wang, Stephanie Tring, Sarah J Plummer, Demetrius Albanes, M Henar Alonso, Christopher I Amos, Kristen Anton, Aaron K Aragaki, Volker Arndt, Elizabeth L Barry, Sonja I Berndt, Stéphane Bezieau, Stephanie Bien, Amanda Bloomer, Juergen Boehm, Marie-Christine Boutron-Ruault, Hermann Brenner, Stefanie Brezina, Daniel D Buchanan, Katja Butterbach, Bette J Caan, Peter T Campbell, Christopher S Carlson, Jose E Castelao, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Iona Cheng, Ya-Wen Cheng, Lee Soo Chin, James M Church, Timothy Church, Gerhard A Coetzee, Michelle Cotterchio, Marcia Cruz Correa, Keith R Curtis, David Duggan, Douglas F Easton, Dallas English, Edith J M Feskens, Rocky Fischer, Liesel M FitzGerald, Barbara K Fortini, Lars G Fritsche, Charles S Fuchs, Manuela Gago-Dominguez, Manish Gala, Steven J Gallinger, W James Gauderman, Graham G Giles, Edward L Giovannucci, Stephanie M Gogarten, Clicerio Gonzalez-Villalpando, Elena M Gonzalez-Villalpando, William M Grady, Joel K Greenson, Andrea Gsur, Marc Gunter, Christopher A Haiman, Jochen Hampe, Sophia Harlid, John F Harju, Richard B Hayes, Philipp Hofer, Michael Hoffmeister, John L Hopper, Shu-Chen Huang, Jose Maria Huerta, Thomas J Hudson, David J Hunter, Gregory E Idos, Motoki Iwasaki, Rebecca D Jackson, Eric J Jacobs, Sun Ha Jee, Mark A Jenkins, Wei-Hua Jia, Shuo Jiao, Amit D Joshi, Laurence N Kolonel, Suminori Kono, Charles Kooperberg, Vittorio Krogh, Tilman Kuehn, Sébastien Küry, Andrea LaCroix, Cecelia A Laurie, Flavio Lejbkowicz, Mathieu Lemire, Heinz-Josef Lenz, David Levine, Christopher I Li, Li Li, Wolfgang Lieb, Yi Lin, Noralane M Lindor, Yun-Ru Liu, Fotios Loupakis, Yingchang Lu, Frank Luh, Jing Ma, Christoph Mancao, Frank J Manion, Sanford D Markowitz, Vicente Martin, Koichi Matsuda, Keitaro Matsuo, Kevin J McDonnell, Caroline E McNeil, Roger Milne, Antonio J Molina, Bhramar Mukherjee, Neil Murphy, Polly A Newcomb, Kenneth Offit, Hanane Omichessan, Domenico Palli, Jesus P Paredes Cotoré, Julyann Pérez-Mayoral, Paul D Pharoah, John D Potter, Conghui Qu, Leon Raskin, Gad Rennert, Hedy S Rennert, Bridget M Riggs, Clemens Schafmayer, Robert E Schoen, Thomas A Sellers, Daniela Seminara, Gianluca Severi, Wei Shi, David Shibata, Xiao-Ou Shu, Erin M Siegel, Martha L Slattery, Melissa Southey, Zsofia K Stadler, Mariana C Stern, Sebastian Stintzing, Darin Taverna, Stephen N Thibodeau, Duncan C Thomas, Antonia Trichopoulou, Shoichiro Tsugane, Cornelia M Ulrich, Franzel J B van Duijnhoven, Bethany van Guelpan, Joseph Vijai, Jarmo Virtamo, Stephanie J Weinstein, Emily White, Aung Ko Win, Alicja Wolk, Michael Woods, Anna H Wu, Kana Wu, Yong-Bing Xiang, Yun Yen, Brent W Zanke, Yi-Xin Zeng, Ben Zhang, Niha Zubair, Sun-Seog Kweon, Jane C Figueiredo, Wei Zheng, Loic Le Marchand, Annika Lindblom, Victor Moreno, Ulrike Peters, Graham Casey, Li Hsu, David V Conti, Stephen B Gruber
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk. Methods: We conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315)...
June 16, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29917117/proteomic-analysis-on-mangrove-plant-avicennia-marina-leaves-reveals-nitric-oxide-enhances-the-salt-tolerance-by-up-regulating-photosynthetic-and-energy-metabolic-protein-expression
#3
Zhi-Jun Shen, Juan Chen, Kabir Ghoto, Wen-Jun Hu, Gui-Feng Gao, Mei-Rong Luo, Zan Li, Martin Simon, Xue-Yi Zhu, Hai-Lei Zheng
Avicennia marina (Forsk.) Vierh is one of the most salt-tolerant mangrove species. Our previous study revealed that nitric oxide (NO) enhanced the salt tolerance of A. marina by promoting salt secretion and Na+ sequestration under salt stress. However, little is known about the regulation of NO on proteomic profiling for this mangrove species. In this study, we used sodium nitroprusside (SNP), an NO donor, to investigate the regulatory mechanism of NO on salt tolerance of A. marina according to physiological and proteomic aspects...
June 15, 2018: Tree Physiology
https://www.readbyqxmd.com/read/29917103/animal-production-and-soil-characteristics-from-integrated-crop-livestock-systems-toward-sustainable-intensification
#4
Paulo César de Faccio Carvalho, Caitlin Adair Peterson, Pedro Arthur de Albuquerque Nunes, Amanda Posselt Martins, William de Souzsa Filho, Vanessa Thoma Bertolazi, Taíse Robinson Kunrath, Aníbal de Moraes, Ibanor Anghinoni
Sustainable intensification of land-use practices has never been more important to ensure food security for a growing world population. When combined under thoughtful management, cover cropping and crop-livestock integration under no-till systems can benefit from unexpected synergies due to their unique features of plant-animal diversification and complex agroecosystem functions. Mimicking the nutrient coupling/decoupling processes of natural ecosystems by diversifying plant and animal components of no-till integrated crop-livestock operations is an essential feature of the design of agroecological systems that support self-regulating feedbacks and lend resilience while increasing productivity and ecosystem service provision...
June 16, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29917085/application-of-the-six-sigma-concept-for-quality-assessment-of-different-strategies-in-dbs-surgery
#5
Witold H Polanski, K Daniel Martin, Swen Günther, Gabriele Schackert, Lisa Klingelhoefer, Mareike Fauser, Alexander Storch, Stephan B Sobottka
Background: For quality analysis, we applied the Six Sigma concept to define quality indicators and their boundaries as well as to compare treatment-dependent outcome data of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease (PD). Methods: The Unified Parkinson Disease Rating Scale (UPDRS) III with on medication and on stimulation, the reduction of daily levodopa equivalence doses (LED), and the stimulation amplitude 1 year after surgery were registered...
June 18, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29917079/the-potential-for-treatment-shortening-with-higher-rifampicin-doses-relating-drug-exposure-to-treatment-response-in-patients-with-pulmonary-tuberculosis
#6
Elin M Svensson, Robin J Svensson, Lindsey H M Te Brake, Martin J Boeree, Norbert Heinrich, Sarah Konsten, Gavin Churchyard, Rodney Dawson, Andreas H Diacon, Gibson S Kibiki, Lilian T Minja, Nyanda E Ntingiya, Ian Sanne, Stephen H Gillespie, Michael Hoelscher, Patrick P J Phillips, Ulrika S H Simonsson, Rob Aarnoutse
Background: Tuberculosis remains a huge public health problem and the prolonged treatment duration obstructs effective tuberculosis control. Higher rifampicin doses have been associated with better bactericidal activity, but optimal dosing is uncertain. This analysis aimed to characterize the relationship between rifampicin plasma exposure and treatment response over 6 months in a recent study investigating the potential for treatment shortening with high-dose rifampicin. Methods: Data were analyzed from 336 patients with pulmonary tuberculosis (97 with pharmacokinetic data) treated with rifampicin doses of 10, 20, or 35 mg/kg...
June 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29917068/yamp-a-containerised-workflow-enabling-reproducibility-in-metagenomics-research
#7
Alessia Visconti, Tiphaine C Martin, Mario Falchi
YAMP is a user-friendly workflow that enables the analysis of whole shotgun metagenomic data while using containerisation to ensure computational reproducibility and facilitate collaborative research. YAMP can be executed on any UNIX-like system, and offers seamless support for multiple job schedulers as well as for Amazon AWS cloud. Although YAMP has been developed to be ready-to-use by non-experts, bioinformaticians will appreciate its flexibility, modularisation, and simple customisation. The YAMP script, parameters, and documentation are available at https://github...
June 18, 2018: GigaScience
https://www.readbyqxmd.com/read/29917042/generation-and-primary-characterization-of-iam-1-a-versatile-new-line-of-conditionally-immortalized-atrial-myocytes-with-preserved-cardiomyogenic-differentiation-capacity
#8
Jia Liu, Linda Volkers, Wanchana Jangsangthong, Cindy I Bart, Marc C Engels, Guangqian Zhou, Martin J Schalij, Dirk L Ypey, Daniël A Pijnappels, Antoine A F de Vries
Aims: The generation of homogeneous cardiomyocyte populations from fresh tissue or stem cells is laborious and costly. A potential solution to this problem would be to establish lines of immortalized cardiomyocytes. However, as proliferation and (terminal) differentiation of cardiomyocytes are mutually exclusive processes, their permanent immortalization causes loss of electrical and mechanical functions. We therefore aimed at developing conditionally immortalized atrial myocyte (iAM) lines allowing toggling between proliferative and contractile phenotypes by a single-component change in culture medium composition...
June 18, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29917002/available-oral-lipid-lowering-agents-could-bring-most-high-risk-patients-to-target-an-estimate-based-on-the-dyslipidemia-international-study-ii-italy
#9
Gaetano M De Ferrari, Gian P Perna, Antonino Nicosia, Luigina Guasti, Gavino Casu, Claudio Cuccia, Francesca Picco, Caterina Strazzella, Rossana Totaro, Stefania Cercone, Laura Canullo, Martin Horack, Dominik Lautsch, Anselm K Gitt, Matteo Di Biase
AIMS: The analysis evaluated the contemporary percentage of patients with established coronary heart disease (CHD) reaching the European guidelines recommended LDL-cholesterol (LDL-C) levels of less than 70 mg/dl and the threshold required for proprotein convertase subtlisin/kexin type 9 reimbursement in Italy (100 mg/dl). It also assessed how these percentages would change in case of diffuse use of ezetimibe. METHODS: The Dyslipidemia International Study II enrolled CHD patients aged at least 18 either on lipid-lowering therapy (LLT) for at least 3 months or not on LLT at the time of the lipid profile...
June 18, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29916988/understanding-the-correlation-between-dsa-complement-activation-and-antibody-mediated-rejection-in-heart-transplant-recipients
#10
Qiuheng Zhang, Michelle Hickey, Diana Drogalis-Kim, Ying Zheng, David Gjertson, Martin Cadeiras, Tam Khuu, Arnold S Baas, Eugene C Depasquale, Nancy J Halnon, Gregory Perens, Juan Alejos, Daniel Cruz, Nsair Ali, Richard Shemin, Murray Kwon, Michael C Fishbein, Abbas Ardehali, Mario Deng, Elaine F Reed
BACKGROUND: Donor specific HLA antibodies (DSA) are associated with increased rates of rejection and of graft failure in cardiac transplantation. The goal of this study was to determine the association of preformed and posttransplant development of newly detected DSA (ndDSA) with antibody mediated rejection (AMR) and characterize the clinical relevance of complement activating DSA in heart allograft recipients. METHODS: The study included 128 adult and 48 pediatric heart transplant patients transplanted between 2010 to 2013...
June 18, 2018: Transplantation
https://www.readbyqxmd.com/read/29916974/evaluation-of-fronto-orbital-advancement-using-titanium-based-internal-fixation-for-corrective-pediatric-craniofacial-surgery
#11
Matthias Kreppel, Martin Kauke, Andrea Grandoch, Ali-Farid Safi, Hans-Joachim Nickenig, Joachim Zöller
BACKGROUND: For successful reshaping of the cranial vault in terms of corrective fronto-orbital advancement (FOA) efficient and reliable internal fixation systems for stabilization of bone fragments are indispensable. The rate of complications and feasibility of corrective FOA with the usage of titanium-based rigid fixation systems is rarely analyzed and discussed. METHODS: The authors retrospectively reviewed the medical records of 42 patients who received corrective FOA with the implementation of titanium internal rigid fixation and consecutive secondary surgery for removal...
June 18, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29916748/exploration-of-a-f-ab-2-fragment-as-the-targeting-agent-of-%C3%AE-radiation-therapy-a-comparison-of-the-therapeutic-benefit-of-intraperitoneal-and-intravenous-administered-radioimmunotherapy
#12
Diane E Milenic, Young-Seung Kim, Kwamena E Baidoo, Karen J Wong, Rachel Barkley, Jose Delgado, Martin W Brechbiel
Refinement of treatment regimens enlisting targeted α-radiation therapy (TAT) is an ongoing effort. Among the variables to consider are the target molecule, radionuclide, dosage, and administration route. The panitumumab F(ab')2 fragment targeting epidermal growth factor receptor tolerated modification with the TCMC chelate as well as radiolabeling with 203 Pb or 212 Pb. Good specific activity was attained when the immunoconjugate was labeled with 212 Pb (9.6 ± 1.4 mCi/mg). Targeting of LS-174T tumor xenografts with the 203 Pb-panitumumab F(ab')2 demonstrated comparable amounts of uptake to the similarly radiolabeled panitumumab IgG...
June 2018: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29916746/on-reviewing
#13
Martin W Brechbiel
No abstract text is available yet for this article.
June 2018: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29916723/barriers-and-facilitators-to-participation-in-a-health-check-for-cardiometabolic-diseases-in-primary-care-a-systematic-review
#14
Anne-Karien M de Waard, Per E Wändell, Martin J Holzmann, Joke C Korevaar, Monika Hollander, Carl Gornitzki, Niek J de Wit, François G Schellevis, Christos Lionis, Jens Søndergaard, Bohumil Seifert, Axel C Carlsson
Background Health checks for cardiometabolic diseases could play a role in the identification of persons at high risk for disease. To improve the uptake of these health checks in primary care, we need to know what barriers and facilitators determine participation. Methods We used an iterative search strategy consisting of three steps: (a) identification of key-articles; (b) systematic literature search in PubMed, Medline and Embase based on keywords; (c) screening of titles and abstracts and subsequently full-text screening...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29916714/quantitative-proteomics-and-phosphoproteomics-analysis-revealed-different-regulatory-mechanisms-of-halothane-and-rendement-napole-genes-in-porcine-muscle-metabolism
#15
Honggang Huang, Tracy L Scheffler, David E Gerrard, Martin R Larsen, Rene Lametsch
Pigs with the Halothane (HAL) and/or Rendement Napole (RN) gene mutations demonstrate abnormal muscle energy metabolism patterns and produce meat with poor quality, classified as pale, soft and exudative (PSE) meat, but it is not well understood how HAL and RN mutations regulate glucose and energy metabolism in porcine muscle. In order to investigate the potential signaling pathways and phosphorylation events related to these mutations, muscle samples were collected from four genotypes of pigs: wildtype, RN, HAL and RN-HAL double mutations and subjected to quantitative proteomic and phosphoproteomic analysis using the TiO2 enrichment strategy...
June 19, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29916703/complexation-of-uranium-vi-with-n-2-hydroxyethyl-ethylenediamine-n-n-n-triacetic-acid-in-aqueous-solution-thermodynamic-studies-and-coordination-analyses
#16
Xingliang Li, Zhicheng Zhang, Leigh R Martin, Shunzhong Luo, Linfeng Rao
N-(2-Hydroxyethyl)ethylenediamine- N, N', N'-triacetic acid (HEDTA, denoted as H3 L in this work, and the three dissociable protons represent those of the three carboxylic groups) is a strong chelating ligand and plays an important role in the treatment and disposal of nuclear wastes as well as separation sciences of f-elements. In this work, the complexation of HEDTA with U(VI) was studied thermodynamically and structurally in aqueous solutions. Potentiometry and microcalorimetry were used to measure the complexation constants (298-343 K) and enthalpies (298 K), respectively, at I = 1...
June 19, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29916690/fuel-free-light-powered-tio-2-pt-janus-micromotors-for-enhanced-nitroaromatic-explosives-degradation
#17
Lei Kong, Carmen C Mayorga-Martinez, Jianguo Guan, Martin Pumera
Nitroaromatic explosives such as 2,4,6-trinitrotoluene (2,4,6-TNT) and 2,4-dinitrotoluene (2,4-DNT) are two common nitroaromatic compounds in ammunition. Their leakage leads to serious environmental pollution and threatens human health. It is important to remove or decompose them rapidly and efficiently. In this work, we present that light-powered TiO2 /Pt Janus micromotors have high efficiency for the "on-the-fly" photocatalytic degradation of 2,4-DNT and 2,4,6-TNT in pure water under UV irradiation...
June 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29916541/effect-of-electric-stimulation-on-human-chondrocytes-and-mesenchymal-stem-cells-under-normoxia-and-hypoxia
#18
Bettina Hiemer, Martin Krogull, Thomas Bender, Josefin Ziebart, Simone Krueger, Rainer Bader, Anika Jonitz-Heincke
During joint movement and mechanical loading, electric potentials occur within cartilage tissue guiding cell development and regeneration. Exposure of cartilage exogenous electric stimulation (ES) may imitate these endogenous electric fields and promote healing processes. Therefore, the present study investigated the influence of electric fields on human chondrocytes, mesenchymal stem cells and the co‑culture of the two. Human chondrocytes isolated from articular cartilage obtained post‑mortally and human mesenchymal stem cells derived from bone marrow (BM‑MSCs) were seeded onto a collagen‑based scaffold separately or as co‑culture...
June 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29916452/antibodies-to-west-nile-virus-in-mexican-pigs
#19
Teresa Merino-Ramos, Elizabeth Loza-Rubio, Edith Rojas-Anaya, Miguel A Martín-Acebes
No abstract text is available yet for this article.
January 2018: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29916390/histopathological-ultrastructural-and-molecular-phylogenetic-analysis-of-a-novel-microsporidium-in-a-loggerhead-sea-turtle-caretta-caretta
#20
S A Martinson, S J Greenwood, D Wadowska, K Martin
Microsporidial spores were identified in the musculature of a loggerhead sea turtle Caretta caretta found dead on the shore in New Brunswick, Canada. Gastroenteritis was diagnosed on gross postmortem examination, with no gross abnormalities detected in the skeletal muscle. Histologically, the microsporidial spores were associated with inflammation and muscular necrosis and measured 1.1-1.7 × 2.2-3.4 µm. Spores were typically identified within sporophorous vesicles and, less often, in sporophorocysts and were weakly Gram positive, had punctate PAS staining, and were occasionally strongly acid-fast...
June 19, 2018: Diseases of Aquatic Organisms
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