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https://www.readbyqxmd.com/read/29055261/the-nosas-score-a-new-and-simple-screening-tool-for-obstructive-sleep-apnea-syndrome-in-depressive-disorder
#1
Kelly Guichard, Helena Marti-Soler, Jean-Arthur Micoulaud-Franchi, Pierre Philip, Pedro Marques-Vidal, Peter Vollenweider, Gerard Waeber, Martin Preisig, José Haba-Rubio, Raphael Heinzer
BACKGROUND: Since the clinical presentation of obstructive sleep apnea syndrome (OSAS) shares common features with major depressive (MDE), the screening of OSAS is challenging in this population. The aim of this study was to assess the effectiveness of the NoSAS score in predicting the presence of OSAS among participants with current MDE and to compare it with the performance of existing screening tools. METHODS: A random sample of the population-based cohort CoLaus (Lausanne, Switzerland) underwent a psychiatric evaluation (PsyCoLaus) and a complete polysomnography at home (HypnoLaus)...
October 5, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29055014/protein-acyltransferase-dhhc3-regulates-breast-tumor-growth-oxidative-stress-and-senescence
#2
Martin E Hemler, Chandan Sharma, Hong-Xing Wang, Qinglin Li, Konstantin Knoblich, Emily S Reisenbichler, Andrea L Richardson
DHHC-type protein acyltransferases may regulate the localization, stability and/or activity of their substrates. In this study, we show that the protein palmitoyltransferase DHHC3 is upregulated in malignant and metastatic human breast cancer. Elevated expression of DHHC3 correlated with diminished patient survival in breast cancer and six other human cancer types. ZDHHC3 ablation in human MDA-MB-231 mammary tumor cell xenografts reduced the sizes of both the primary tumor and metastatic lung colonies. Gene array data and fluorescence dye assays documented increased oxidative stress and senescence in ZDHHC3-ablated cells...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29055012/type-i-interferon-enhances-necroptosis-of-salmonella-typhimurium-infected-macrophages-by-impairing-antioxidative-stress-responses
#3
Nina Judith Hos, Raja Ganesan, Saray Gutiérrez, Deniz Hos, Jennifer Klimek, Zeinab Abdullah, Martin Krönke, Nirmal Robinson
Salmonella enterica serovar Typhimurium exploits the host's type I interferon (IFN-I) response to induce receptor-interacting protein (RIP) kinase-mediated necroptosis in macrophages. However, the events that drive necroptosis execution downstream of IFN-I and RIP signaling remain elusive. In this study, we demonstrate that S Typhimurium infection causes IFN-I-mediated up-regulation of the mitochondrial phosphatase Pgam5 through RIP3. Pgam5 subsequently interacts with Nrf2, which sequesters Nrf2 in the cytosol, thereby repressing the transcription of Nrf2-dependent antioxidative genes...
October 20, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/29054918/non-invasive-in-vivo-neuropathology-of-the-c9orf72-related-als-ftd-syndrome
#4
EDITORIAL
Martin R Turner
No abstract text is available yet for this article.
October 20, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29054900/herpes-zoster-ophthalmicus-in-a-1-year-old-child
#5
Zaid Makzal, Martin Edwards
No abstract text is available yet for this article.
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054855/h-ras-deletion-protects-against-angiotensin-ii-induced-arterial-hypertension-and-cardiac-remodeling-through-protein-kinase-g-i%C3%AE-pathway-activation
#6
Paloma Martín-Sánchez, Alicia Luengo, Mercedes Griera, María Jesús Orea, Marina López-Olañeta, Antonio Chiloeches, Enrique Lara-Pezzi, Sergio de Frutos, Manuel Rodríguez-Puyol, Laura Calleros, Diego Rodríguez-Puyol
Ras proteins regulate cell survival, growth, differentiation, blood pressure, and fibrosis in some organs. We have demonstrated that H-ras gene deletion produces mice hypotension via a soluble guanylate cyclase-protein kinase G (PKG)-dependent mechanism. In this study, we analyzed the consequences of H-ras deletion on cardiac remodeling induced by continuous angiotensin II (AngII) infusion and the molecular mechanisms implied. Left ventricular posterior wall thickness and mass and cardiomyocyte cross-sectional area were similar between AngII-treated H-Ras knockout (H-ras(-/-) ) and control wild-type (H-ras(+/+) ) mice, as were extracellular matrix protein expression...
October 20, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29054806/nutritional-physiology-of-mahi-mahi-coryphaena-hippurus-postprandial-metabolic-response-to-different-diets-and-metabolic-impacts-on-swim-performance
#7
John D Stieglitz, Daniel D Benetti, Martin Grosell
Migratory pelagic fish species, such as the mahi-mahi (Coryphaena hippurus), must balance numerous metabolic demands simultaneously in order to survive in a challenging oceanic environment. Energetic support for such demands comes from a variety of natural prey items in the wild and can come from manufactured pelletized feed in captivity. This study quantified postprandial metabolism, commonly referred to as specific dynamic action (SDA), over time in adult mahi-mahi (706±25g; 38±0.7cm FL) in response to satiation feeding using three different natural and manufactured diets...
October 17, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29054675/evidence-of-fatigue-disordered-sleep-and-peripheral-inflammation-but-not-increased-brain-tspo-expression-in-seasonal-allergy-a-11-c-pbr28-pet-study
#8
Sandra Tamm, Simon Cervenka, Anton Forsberg, Johanna Estelius, Johan Grunewald, Pär Gyllfors, Bianka Karshikoff, Eva Kosek, Jon Lampa, Catarina Lensmar, Victoria Strand, Torbjörn Åkerstedt, Christer Halldin, Martin Ingvar, Caroline Olgart Höglund, Mats Lekander
Allergy is associated with non-specific symptoms such as fatigue, sleep problems and impaired cognition. One explanation could be that the allergic inflammatory state includes activation of immune cells in the brain, but this hypothesis has not been tested in humans. The aim of the present study was therefore to investigate seasonal changes in the glial cell marker translocator protein (TSPO), and to relate this to peripheral inflammation, fatigue and sleep, in allergy. We examined 18 patients with severe seasonal allergy, and 13 healthy subjects in and out-of pollen season using positron emission tomography (n = 15/13) and the TSPO radioligand [(11)C]PBR28...
October 17, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29054663/characterization-of-bacterial-diversity-in-contaminated-groundwater-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#9
Misty S Martin, Inês C Santos, Doug D Carlton, Paula Stigler-Granados, Zacariah L Hildenbrand, Kevin A Schug
Groundwater is a major source for drinking water in the United States, and therefore, its quality and quantity is of extreme importance. One major concern that has emerged is the possible contamination of groundwater due to the unconventional oil and gas extraction activities. As such, the impacts of exogenous contaminants on microbial ecology is an area to be explored to understand what are the chemical and physical conditions that allow the proliferation of pathogenic bacteria and to find alternatives for water treatment by identifying organic-degrading bacteria...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054630/effects-of-land-use-and-seasonality-on-stream-water-quality-in-a-small-tropical-catchment-the-headwater-of-c%C3%A3-rrego-%C3%A3-gua-limpa-s%C3%A3-o-paulo-brazil
#10
Valdemir Rodrigues, Joan Estrany, Mauricio Ranzini, Valdir de Cicco, José Mª Tarjuelo Martín-Benito, Javier Hedo, Manuel E Lucas-Borja
Stream water quality is controlled by the interaction of natural and anthropogenic factors over a range of temporal and spatial scales. Among these anthropogenic factors, land cover changes at catchment scale can affect stream water quality. This work aims to evaluate the influence of land use and seasonality on stream water quality in a representative tropical headwater catchment named as Córrego Água Limpa (Sao Paulo, Brasil), which is highly influenced by intensive agricultural activities and urban areas...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054602/stat1-gain-of-function-and-stat3-loss-of-function-mutations-impair-il-17-and-il-22-immunity-associated-with-cmc
#11
Julia Hiller, Beate Hagl, Renate Effner, Anne Puel, Martin Schaller, Birgit Mascher, Stefanie Eyerich, Kilian Eyerich, Annette F Jansson, Johannes Ring, Jean-Laurent Casanova, Ellen D Renner, Claudia Traidl-Hoffmann
No abstract text is available yet for this article.
October 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29054578/tularemia-in-interepidemic-period
#12
Javier Miguel Martín Guerra, Miguel Martín Asenjo, José María Prieto de Paula
No abstract text is available yet for this article.
October 17, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29054576/skin-infection-in-a-renal-transplant-recipient
#13
Meritxell Royuela, Juliana Jaramillo, María Teresa Martín, Oscar Len
No abstract text is available yet for this article.
October 17, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29054573/simulation-as-a-surgical-teaching-model
#14
José Luis Ruiz-Gómez, José Ignacio Martín-Parra, Mónica González-Noriega, Carlos Godofredo Redondo-Figuero, José Carlos Manuel-Palazuelos
Teaching of surgery has been affected by many factors over the last years, such as the reduction of working hours, the optimization of the use of the operating room or patient safety. Traditional teaching methodology fails to reduce the impact of these factors on surgeońs training. Simulation as a teaching model minimizes such impact, and is more effective than traditional teaching methods for integrating knowledge and clinical-surgical skills. Simulation complements clinical assistance with training, creating a safe learning environment where patient safety is not affected, and ethical or legal conflicts are avoided...
October 17, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29054572/chaotic-genetic-algorithm-and-adaboost-ensemble-metamodeling-approach-for-optimum-resource-planning-in-emergency-departments
#15
Milad Yousefi, Moslem Yousefi, Ricardo Poley Martins Ferreira, Joong Hoon Kim, Flavio S Fogliatto
Long length of stay and overcrowding in emergency departments (EDs) are two common problems in the healthcare industry. To decrease the average length of stay (ALOS) and tackle overcrowding, numerous resources, including the number of doctors, nurses and receptionists need to be adjusted, while a number of constraints are to be considered at the same time. In this study, an efficient method based on agent-based simulation, machine learning and the genetic algorithm (GA) is presented to determine optimum resource allocation in emergency departments...
October 17, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29054538/lower-mitochondrial-dysfunction-in-survivor-septic-patients-with-mitochondrial-dna-haplogroup-jt
#16
Leonardo Lorente, María M Martín, Ester López-Gallardo, José Ferreres, Jordi Solé-Violán, Lorenzo Labarta, César Díaz, Alejandro Jiménez, Julio Montoya, Eduardo Ruiz-Pesini
OBJECTIVE: The comparison on mitochondrial function between severe septic patients and healthy control subjects according to mitochondrial deoxyribonucleic acid (mtDNA) haplogroup has not been previously reported; and this was the objective of the current study. METHODS: Prospective, multicenter, observational study. We obtained blood samples from 198 severe septic patients at days 1, 4 and 8 of severe sepsis diagnosis and from 96 sex- and age-matched healthy controls to determine mtDNA haplogroup and platelet respiratory complex IV (CIV) specific activity...
October 17, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29054470/circulating-adiponectin-increases-in-obese-women-after-sleeve-gastrectomy-or-gastric-bypass-driving-beneficial-metabolic-changes-but%C3%A2-with-no-relationship-with-carotid-intima-media-thickness
#17
Jesús M Gómez-Martin, José A Balsa, Enrique Aracil, María Insenser, Pablo Priego, Héctor F Escobar-Morreale, José I Botella-Carretero
BACKGROUND & AIMS: Obesity surgery induces beneficial effects in metabolic and cardiovascular parameters. Adiponectin increase might be associated with some of these changes. However, direct comparison between different surgical techniques has not been extensively performed. METHODS: We studied 20 obese women submitted to laparoscopic Roux en Y gastric bypass (RYGB) and 20 to sleeve gastrectomy (SG). Twenty control women matched for age and baseline metabolic profiles were also included...
October 12, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29054440/external-validation-of-heart-type-fatty-acid-binding-protein-high-sensitivity-cardiac-troponin-and-electrocardiography-as-rule-out-for-acute-myocardial-infarction
#18
Christopher B Van Hise, Jaimi H Greenslade, William Parsonage, Martin Than, Joanna Young, Louise Cullen
OBJECTIVE: To externally validate a clinical decision rule incorporating heart fatty acid binding protein (h-FABP), high-sensitivity troponin (hs-cTn) and electrocardiogram (ECG) for the detection of acute myocardial infarction (AMI) on presentation to the Emergency Department. We also investigated whether this clinical decision rule improved identification of AMI over algorithms incorporating hs-cTn and ECG only. DESIGN AND METHODS: This study included data from 789 patients from the Brisbane ADAPT cohort and 441 patients from the Christchurch TIMI RCT cohort...
October 17, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29054399/determination-of-molecular-subtypes-of-diffuse-large-b-cell-lymphoma-using-a-reverse-transcriptase-multiplex-ligation-dependent-probe-amplification-classifier-a-calym-study
#19
Victor Bobée, Philippe Ruminy, Vinciane Marchand, Pierre-Julien Viailly, Ahmad Abdel Sater, Liana Veresezan, Fanny Drieux, Caroline Bérard, Elodie Bohers, Sylvain Mareschal, Sydney Dubois, Jean-Philippe Jais, Karen Leroy, Martin Figeac, Jean-Michel Picquenot, Thierry Jo Molina, Gilles Salles, Corinne Haioun, Hervé Tilly, Fabrice Jardin
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. It includes three major subtypes termed germinal center B-cell-like, activated B-cell-like, and primary mediastinal B-cell lymphoma. With the emergence of novel targeted therapies, accurate methods capable of interrogating this cell-of-origin classification should soon become essential in the clinics. To address this issue, we developed a novel gene expression profiling DLBCL classifier based on reverse transcriptase multiplex ligation-dependent probe amplification...
October 13, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29054346/mixed-ploidy-species-progress-and-opportunities-in-polyploid-research
#20
REVIEW
Filip Kolář, Martin Čertner, Jan Suda, Peter Schönswetter, Brian C Husband
Mixed-ploidy species harbor a unique form of genomic and phenotypic variation that influences ecological interactions, facilitates genetic divergence, and offers insights into the mechanisms of polyploid evolution. However, there have been few attempts to synthesize this literature. We review here research on the cytotype distribution, diversity, and dynamics of intensively studied mixed-ploidy species and consider the implications for understanding mechanisms of polyploidization such as cytotype formation, establishment, coexistence, and post-polyploid divergence...
October 17, 2017: Trends in Plant Science
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