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On-X heart valve

Peter Seizer, Michaela Rockenstiehl, Suzanne Fateh-Moghadam, Susanne Haen, Ferruh Artunc, Martin R Müller, Azadeh Ebrahimi, Reimer Riessen, Meinrad Gawaz, Falko Fend, Michael Haap
HISTORY AND ADMISSION FINDINGS: A 55-year old man suffers from progressive, distinctive dyspnoea and physical weakness since 5 days. Due to ST-segment changes in the ECG and a positive troponin-test, the primary care physician initiates an hospitalization. INVESTIGATIONS: After admission, the laboratory tests confirm the elevated troponin-values, and show additionally elevated pro-brain-natriuric-peptide-values. The coronary angiography presents a highly reduced left ventricular function, an aortic insufficiency III° and a coronary heart disease...
September 2016: Deutsche Medizinische Wochenschrift
Richard W Harbron, Claire-Louise Chapple, John J O'Sullivan, Kate E Best, Amy Berrington de González, Mark S Pearce
OBJECTIVES: To estimate the risk of developing cancer in relation to the typical radiation doses received from a range of X-ray guided cardiac catheterisations in children, taking variable survival into account. METHODS: Radiation doses were estimated for 2749 procedures undertaken at five UK hospitals using Monte Carlo simulations. The lifetime attributable risk (LAR) of cancer incidence was estimated using models developed by the Biological Effects of Ionising Radiation committee, based on both normal life expectancy, and as a function of attained age, from 20 to 80 years, to take reduced life expectancy into account...
August 18, 2016: Heart: Official Journal of the British Cardiac Society
J Q Shen, L Wei, L M Xia, H Lai, Y X Sun, X N Sun, C Liu, Z H Yang, C S Wang
OBJECTIVE: To compare the results of aortic valve replacement through anterolateral minithoracotomy (RT) and partial upper hemisternotomy (PS) approaches. METHODS: This was a retrospective, observational, cohort study of collected data on 297 patients undergoing isolated primary aortic valve replacement between July 2009 and March 2016 at Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University. There were 174 male and 123 female patients, aging from 15 to 73 years with a mean age of (51±13) years...
August 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
R Guidoin, R Zegdi, J Lin, J Mao, O Rochette-Drouin, D How, X Guan, P Bruneval, L Wang, L Germain, Z Zhang
INTRODUCTION: Prior to deployment, the percutaneous heart valves must be crimped and loaded into sheaths of diameters that can be as low as 6mm for a 23mm diameter valve. However, as the valve leaflets are fragile, any damage caused during this crimping process may contribute to reducing its long-term durability in vivo. MATERIAL AND METHOD: Bovine pericardium percutaneous valves were manufactured as follows. The leaflets were sutured on a nitinol frame. A polyester cuff fabric served as a buffer between the pericardium and the stent...
July 22, 2016: Morphologie: Bulletin de L'Association des Anatomistes
Khadija Aman
BACKGROUND: Mechanical prosthetic heart valves have been used for many decades to replace damaged native valves. Guidelines mandate the use of anticoagulant therapy in patients with mechanical prosthetic valves of any type, irrespective of the position in the heart. The rationale for this is to prevent valve thrombosis and thromboembolic complications without increasing the risk of excess bleeding. We report a case involving a patient with a functioning aortic mechanical valve without any anticoagulation therapy for 33 years...
2016: Journal of Medical Case Reports
L Dong, Y K Shi, J P Xu, E Y Zhang, J C Liu, Y X Li, Y M Ni, Q Yang, T Han, B Fu, J Chen, L Ren, S L Wei, H Chen, K X Liu, F X Yu, J S Liu, M D Xiao, S M Wu, K L Zhang, H L Huang, S L Jiang, C H Qiao, C S Wang, Z Y Xu, X M Zhou, D J Wang, L X Ni, Y B Xiao, S L Jiang, G M Zhang, G Y Liang, S Y Yang, P Bo, Q J Zhong, J B Zhang, X Zhang, Y B Zhu, X Teng, P Zhu, F Huang, Y M Xiao, G Q Cao, H Tian, L M Xia, F L Lu, Y Q Liu, D X Liu, H Xu, Y Yuan, M Li, C Chang, X C Wu, Z Xu, P Guo, Y J Bai, W B Xue, X Y Jiang, Z H Na, Q Y Zeng, H Cai, Y L Wang, R Xiong, S Jin, X M Zheng, D Wu
OBJECTIVE: To investigate the optimal anticoagulation methods and monitoring strategy for Chinese patients undergoing heart valve replacement, which is potentially quite different from western populations. METHODS: In this multicenter prospective cohort study, the anticoagulation and monitoring strategy data was acquired from 25 773 in-hospital patients in 35 medical centers and 20 519 patients in outpatient clinic in 11 medical centers from January 1st, 2011 to December 31th, 2015...
May 24, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
L Chu, J Zhang, Y N Li, X Meng, Y Y Liu
OBJECTIVE: To investigate the clinical treatment of infective endocarditis with vegetations in pregnant women and the outcomes of the gestation. METHODS: Nine cases of pregnant women diagnosed as infective endocarditis with vegetations in Beijing Anzhen Hospital, Capital Medical University from January 2001 to October 2015 were enrolled in retrospective analysis. Consultations were held by doctors from department of obstetrics, anesthesiology, cardiology, cardial surgery and extracorporeal circulation to decide the individualized treatment plan for the 9 cases of pregnant women after admissions...
May 25, 2016: Zhonghua Fu Chan Ke za Zhi
Cassandra Smith, Muhammad Asrar Ul Haq, George Jerums, Erik Hanson, Alan Hayes, Jason D Allen, Melissa Sbaraglia, Steve Selig, Chiew Wong, David L Hare, Itamar Levinger
Left ventricular diastolic dysfunction (LVDD) is one of the earliest signs for abnormal cardiac function in patients with type 2 diabetes (T2DM). It is important to explore the risk factors that will assist in identifying the severity of the LVDD in this population. We examined the influences of fitness and fatness on the level of left ventricular (LV) impairment in patients with T2DM. Twenty-five patients (age: 64.0 ± 2.5 years, body mass index [BMI] = 36.0 ± 1.5 kg/m(2), mean ± standard error of measurement) with T2DM and preserved systolic function, but impaired diastolic function, mitral valve (MV) E/e', participated in the study...
2016: Clinical Medicine Insights. Cardiology
Kei Takahashi, Hiroaki Suzuki, Takero Arai, Yasuhisa Okuda
We describe a case of anaphylaxia that occurred in a 67-year-old man. He was planned to have an operation on mitral valve prolapse (MVP) for mitral regurgitation (MR). Morphine 5 mg was injected intramusculaly 45 min before operation. Since then, he felt itchy sensation around his inguinal region. After he came to the operating room, he felt itchy sensation all over the body. Initially, his vatal signs were stable. We started to give extracellular fluid including ulinastatin 300,000 U, methylprednisolone 2 g, and ranitidine 50 mg...
April 2016: Masui. the Japanese Journal of Anesthesiology
Şaban Gürcan, Selahattin Ünlü, Figen Kuloğlu, Aynur Karadenizli, Mert Ahmet Kuşkucu
Aggregatibacter (Actinobacillus) actinomycetemcomitans, a small, gram-negative coccobacillus that grows slow and fastidious, is generally colonized in the oral cavity. It is a rarely seen bacterium because of the difficulty of isolation but it can be a causative agent for dental infections and infective endocarditis (IE) particularly in the persons having prosthetic heart valves. In this report, a possible IE case caused by A.actinomycetemcomitans in a patient with aortic valve replacement has been presented...
April 2016: Mikrobiyoloji Bülteni
Judith Kramer, Simon Biner, Michael Ghermezi, Gregg S Pressman, Hezzi Shmueli, Jason Shimiaie, Arie Finkelstein, Shmuel Banai, Arie Steinvil, Eric Buffle, Galit Aviram, Meirav Ingbir, Nahum Nesher, Gad Keren, Yan Topilsky
AIM: To assess the impact of left ventricular (LV) filling parameters on outcomes following trans-catheter aortic valve replacement (TAVR). METHODS AND RESULTS: A total of 526 TAVR patients were compared with 300 patients with severe aortic stenosis (AS) treated conservatively. Clinical variables were collected along with echocardiographic data at baseline, 1 month, and 6 months after study entry. End points included all-cause mortality and the combination of death and heart failure admission...
May 10, 2016: European Heart Journal Cardiovascular Imaging
Nima Mirkhani, Mohammad Reza Davoudi, Pedram Hanafizadeh, Daryoosh Javidi, Niloofar Saffarian
Numerical simulation of the bileaflet mechanical heart valves (BMHVs) has been of interest for many researchers due to its capability of predicting hemodynamic performance. A lot of studies have tried to simulate this three-dimensional complex flow in order to analyze the effect of different valve designs on the blood flow pattern. However, simplified models and prescribed motion for the leaflets were utilized. In this paper, transient complex blood flow in the location of ascending aorta has been investigated in a realistic model by fully coupled simulation...
September 2016: Cardiovascular Engineering and Technology
Pei-Ni Jone, Michael M Ross, John A Bracken, Matthew J Mulvahill, Michael V Di Maria, Thomas E Fagan
BACKGROUND: Fused real-time three-dimensional transesophageal echocardiography and fluoroscopy has been used in adult patients during percutaneous mitral valve and aortic valve procedures. The use of fused echocardiographic/x-ray fluoroscopic imaging (FEX) in pediatric patients undergoing congenital heart disease catheterization has not been evaluated for feasibility and safety. The aims of this study were to assess the feasibility and safety of FEX for interventional guidance and to perform a comparison of atrial septal defect (ASD) device closure using this technology with traditional guidance methods...
June 2016: Journal of the American Society of Echocardiography
Chiau-Suong Liau, Jong-Kai Hsiao, I-Tseng Chu
UNLABELLED: A 37-year-old female presented to our facility suffering from exertional dyspnea for 2-3 months. Her chest x-ray showed a nodular shadow in the right lower lung, and chest CT revealed a pulmonary arteriovenous fistula (PAVF). Subsequent echocardiographic examination detected no intra-cardiac shunt but did indicate pulmonary hypertension as evidenced by a tricuspid regurgitation flow velocity of 4.17 M/sec. Contrast echocardiography with antecubital vein injection of agitated normal saline demonstrated visualization of the left heart chambers compatible with PAVF...
January 2016: Acta Cardiol Sin
Chuanbao Li, Dapeng Dai, Guoxin Hu, Chengwei Pu, Yapo Cao, Jainping Cai
OBJECTIVE: To develop and evaluate a warfarin-dosing algorithm method which can be used to guide the adjustment of warfarin maintenance dose in Chinese Han population. METHODS: A total of 512 patients with steady warfarin taking were recruited from Beijing Hospital during May 2012 to December 2014. Indications for warfarin prescribing included prosthetic heart valve, atrial fibrillation and pulmonary embolism. Genomic DNAs were extracted from blood samples and used for the genetic polymorphism analysis of VKORC1 and CYP2C9 (include (*)3 and (*)13 alleles)...
March 15, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
J B Chuai, L Shi, X Y Ma, D Wu, K Kang, S L Jiang
This study was carried out to determine the curative effect of low-intensity anticoagulant therapy by observing the oral administration of warfarin (anticoagulant therapy) on patients who had undergone mechanical heart valve replacement (MHVR) surgery with subsequent anticoagulation complications. Fifty patients who underwent MHVR in the Second Affiliated Hospital of Harbin Medical University and 52 patients in the Cardiovascular Surgery of Daqing Oilfield General Hospital between January 2013 and January 2016 were selected (63 males and 39 females, ages 26-77 years)...
January 2016: Journal of Biological Regulators and Homeostatic Agents
Oscar Fabregat-Andres, Federico Paredes, María Monsalve, Javier Milara, Francisco Ridocci-Soriano, Sonia Gonzalez-Hervas, Armando Mena, Lorenzo Facila, Fernando Hornero, Salvador Morell, Juan Martinez-Leon, Julio Cortijo
OBJECTIVE: Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that has been proposed to play a protective role in mouse models of cardiac ischemia and heart failure, suggesting that PGC-1α could be relevant as a prognostic marker. Our previous studies showed that the estimation of peripheral mRNA PGC-1α expression was feasible and that its induction correlated with the extent of myocardial necrosis and left ventricular remodeling in patients with myocardial infarction...
November 26, 2015: Anatolian Journal of Cardiology
C N Xu, Y Liu, X F Li, W S Chen, X L Yang, X W Wang, Y S Zhu, H L Li, R Ma, M Chen, S Q Yu, J Yang
OBJECTIVE: To evaluate the efficacy of transcatheter intervention of paravalvular leakage (PVL) after mitral valve replacement. METHODS: Present respective study included 15 patients (8 males and mean age (53.5±11.7) years) with mitral PVL who underwent interventional therapy in our hospital from April 2014 to May 2015. There were 9 cases with NYHA heart function Ⅲ, 6 cases with NYHA heart function Ⅳ. Left ventricular ejection fraction was (46.8±8.2)%, and mitral regurgitation volume was 12...
March 2016: Zhonghua Xin Xue Guan Bing za Zhi
Mahmood Hosseinzadeh Maleki, Toba Kazemi, Navid Davoody
A 94-year-old woman presented with dizziness and hypotension of 2 days' duration. She denied any syncope, presyncope, or angina. She had received a permanent pacemaker 12 years previously for the management of complete heart block (CHB), but she failed to program it. Twelve-lead electrocardiography revealed CHB with ventricular escape rhythm (40/min), so we inserted a temporary pacemaker. Anteroposterior chest X-ray showed trachea, aortic arch, and severe mitral valve calcification. Tracheal calcification is usually seen after 40 years old without clinical importance...
October 27, 2015: Journal of Tehran Heart Center
Fernanda L Paganelli, Johannes Huebner, Kavindra V Singh, Xinglin Zhang, Willem van Schaik, Dominique Wobser, Johanna C Braat, Barbara E Murray, Marc J M Bonten, Rob J L Willems, Helen L Leavis
Enterococcus faecium is a common cause of nosocomial infections, of which infective endocarditis is associated with substantial mortality. In this study, we used a microarray-based transposon mapping (M-TraM) approach to evaluate a rat endocarditis model and identified a gene, originally annotated as "fruA" and renamed "bepA," putatively encoding a carbohydrate phosphotransferase system (PTS) permease (biofilm and endocarditis-associated permease A [BepA]), as important in infective endocarditis. This gene is highly enriched in E...
July 15, 2016: Journal of Infectious Diseases
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