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https://www.readbyqxmd.com/read/29434122/spinocerebellar-ataxia-type-31-with-blepharospasm
#1
Sakiko Itaya, Zen Kobayashi, Kokoro Ozaki, Nozomu Sato, Yoshiyuki Numasawa, Kinya Ishikawa, Takanori Yokota, Hiroshi Matsuda, Shuzo Shintani
A 58-year-old man consulted our hospital due to a 2-year history of dysarthria and a 1-month history of blepharospasm. In addition to the ataxic dysarthria and blepharospasm, a neurological examination demonstrated slight ataxia of the trunk and lower limbs. Brain MRI demonstrated atrophy of the upper portion of the cerebellar vermis. Gene analysis established a diagnosis of spinocerebellar ataxia type 31 (SCA31). SPECT with the three-dimensional stereotaxic ROI template (3DSRT) software program demonstrated hyperperfusion in the lenticular nucleus and thalamus...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29432339/18f-choline-pet-mr-can-detect-and-delineate-local-recurrence-after-high-intensity-focused-ultrasound-therapy-of-prostate-cancer
#2
Irene A Burger, Andrei Gafita, Julian Müller, Benedikt Kranzbühler, Olivio F Donati, Daniel Eberli
Restaging local recurrence after high-intensity focused ultra-sound (HIFU) is based on multiparametric MRI (mpMRI). However, postinterventional changes of the tissue, such as edema or hemorrhage, are limiting tumor detection on mpMRI. We present a case of a rising prostate-specific antigen values, negative mpMRI, and a Gleason score of 4+4 on template biopsy after HIFU. On F-choline PET/MR, high focal uptake was detected at the location of positive biopsy. Re-HIFU based on the fused F-choline PET/MR images was performed, followed by a recurrence-free period of 11 months...
February 9, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29423465/dually-responsive-gold-iron-oxide-heterodimers-merging-stimuli-responsive-surface-properties-with-intrinsic-inorganic-material-features
#3
Hamilton Kakwere, Maria Elena Materia, Alberto Curcio, Mirko Prato, Ayyappan Sathya, Simone Nitti, Teresa Pellegrino
We demonstrate a versatile approach for the preparation of dually responsive smart inorganic heterostructures (HSs) with the potential for exploitation in nanomedicine. We utilize Au-FexOy dimers as templates for generating smart inorganic HSs with a pH-responsive coating and a thermo-responsive coating attached to iron oxide and gold nanoparticles (NPs), respectively. First, a thiol-modified thermo-responsive (PNIPAAM-co-PEGA) polymer could be selectively attached to the gold domain by ligand exchange. The sequential attachment of a catechol-modified initiator to the iron oxide surface enables the in situ polymerization of a pH-responsive (PDMAEA) polymer...
February 9, 2018: Nanoscale
https://www.readbyqxmd.com/read/29407456/a-stereotaxic-breed-averaged-symmetric-t2w-canine-brain-atlas-including-detailed-morphological-and-volumetrical-data-sets
#4
Björn Nitzsche, Johannes Boltze, Eberhard Ludewig, Thomas Flegel, Martin J Schmidt, Johannes Seeger, Henryk Barthel, Olivia W Brooks, Matthew J Gounis, Michael H Stoffel, Sabine Schulze
Stereotaxic systems and automatic tissue segmentation routines enable neuronavigation as well as reproducible processing of neuroimage datasets. Such systems have been developed for humans, non-human-primates, sheep, and rodents, but not for dogs. Although dogs share important neurofunctional and -anatomical features with humans, and in spite of their importance in translational neuroscience, little is known about the variability of the canine brain morphology and, possibly related, function. Moreover, we lack templates, tissue probability maps (TPM), and stereotaxic brain labels for implementation in standard software utilities such as Statistical Parametric Mapping (SPM)...
January 30, 2018: NeuroImage
https://www.readbyqxmd.com/read/29403349/group-analysis-in-mne-python-of-evoked-responses-from-a-tactile-stimulation-paradigm-a-pipeline-for-reproducibility-at-every-step-of-processing-going-from-individual-sensor-space-representations-to-an-across-group-source-space-representation
#5
Lau M Andersen
An important aim of an analysis pipeline for magnetoencephalographic data is that it allows for the researcher spending maximal effort on making the statistical comparisons that will answer the questions of the researcher, while in turn spending minimal effort on the intricacies and machinery of the pipeline. I here present a set of functions and scripts that allow for setting up a clear, reproducible structure for separating raw and processed data into folders and files such that minimal effort can be spend on: (1) double-checking that the right input goes into the right functions; (2) making sure that output and intermediate steps can be accessed meaningfully; (3) applying operations efficiently across groups of subjects; (4) re-processing data if changes to any intermediate step are desirable...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29400912/classic-block-design-pseudo-resting-state-fmri-changes-after-a-neurorehabilitation-program-in-patients-with-multiple-sclerosis
#6
Deborah Pareto, Jaume Sastre-Garriga, Juli Alonso, Ingrid Galán, Maria Jesus Arévalo, Marta Renom, Xavier Montalban, Àlex Rovira
BACKGROUND AND PURPOSE: The goal of this study was to assess changes in the resting-state networks (RSNs) of patients with multiple sclerosis (MS) after a cognitive rehabilitation program (CRP), by retrospectively analyzing functional magnetic resonance imaging (fMRI) studies using the classical block design. METHODS: Fifteen patients with MS (2 primary progressive, 3 relapsing-remitting, 10 secondary progressive) were scanned before and after the CRP on a 1.5T MRI scanner...
February 5, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29398961/comparison-of-standardized-uptake-value-ratio-calculations-in-amyloid-positron-emission-tomography-brain-imaging
#7
Karin Knešaurek, Geoffrey Warnock, Lale Kostakoglu, Cyrill Burger
Amyloid positron emission tomography (PET) imaging with florbetapir 18F (18F-AV-45) allows in vivo assessment of cerebral amyloid load and can be used in the evaluation of progression of Alzheimer's disease (AD) and other dementias associated with b-amyloid. However, cortical amyloid deposition can occur in healthy cases, as well as in patients with AD and quantification of cortical amyloid burden can improve the 18F-AV-45 PET imaging evaluations. The quantification is mostly performed by cortical-to-cerebellum standardized uptake value ratio (SUVr)...
January 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29395621/current-practices-in-clinical-neurofeedback-with-functional-mri-analysis-of-a-survey-using-the-tidier-checklist
#8
Elizabeth Randell, Rachel McNamara, Leena Subramanian, Kerenza Hood, David Linden
BACKGROUND: A core principle of creating a scientific evidence base is that results can be replicated in independent experiments and in health intervention research. The TIDieR (Template for Intervention Description and Replication) checklist has been developed to aid in summarising key items needed when reporting clinical trials and other well designed evaluations of complex interventions in order that findings can be replicated or built on reliably. Neurofeedback (NF) using functional MRI (fMRI) is a multicomponent intervention that should be considered a complex intervention...
January 21, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29379899/fast-geodesic-regression-for-population-based-image-analysis
#9
Yi Hong, Polina Golland, Miaomiao Zhang
Geodesic regression on images enables studies of brain development and degeneration, disease progression, and tumor growth. The high-dimensional nature of image data presents significant computational challenges for the current regression approaches and prohibits large scale studies. In this paper, we present a fast geodesic regression method that dramatically decreases the computational cost of the inference procedure while maintaining prediction accuracy. We employ an efficient low dimensional representation of diffeomorphic transformations derived from the image data and characterize the regressed trajectory in the space of diffeomorphisms by its initial conditions, i...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/29360805/mild-cerebellar-injury-does-not-significantly-affect-cerebral-white-matter-microstructural-organization-and-neurodevelopmental-outcome-in-a-contemporary-cohort-of-preterm-infants
#10
Richelle E M Senden, Kristin Keunen, Niek E van der Aa, Alexander Leemans, Ivana Isgum, Max A Viergever, Jeroen Dudink, Linda S de Vries, Floris Groenendaal, Manon J N L Benders
BACKGROUND: Preterm birth is associated with an increased risk of cerebellar injury. The aim of this study was to assess the impact of cerebellar hemorrhages (CBH) on cerebral white matter microstructural tissue organization and cerebellar volume at term equivalent age (TEA) in extremely preterm infants. Furthermore, we aimed to evaluate the association between CBH and neurodevelopmental outcome in late infancy. METHODS: 24 preterm infants with punctate CBH were included and each matched to two preterm control infants...
January 23, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29356506/comparing-strategies-in-the-design-of-responsive-contrast-agents-for-magnetic-resonance-imaging-a-case-study-with-copper-and-zinc
#11
Valérie C Pierre, Sarah M Harris, Sylvie L Pailloux
Magnetic resonance imaging (MRI) has emerged over the years as one of the preferred modalities for medical diagnostic and biomedical research. It has the advantage over other imaging modalities such as positron emission tomography and X-ray of affording high resolution three-dimensional images of the body without using harmful radiation. The use of contrast agents has further expanded this technique by increasing the contrast between regions where they accumulate and background tissues. As MRI most often measures the relaxation rate of water throughout the body, contrast agents function by modulating the intensity of the water signal either via improved relaxation or via saturation transfer to selected exchangeable proton...
January 22, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29354004/magnetic-resonance-image-texture-analysis-of-the-periaqueductal-gray-matter-in-episodic-migraine-patients-without-t2-visible-lesions
#12
Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Shengyuan Yu, Lin Ma
Objective: The periaqueductal gray matter (PAG), a small midbrain structure, presents dysfunction in migraine. However, the precise neurological mechanism is still not well understood. Herein, the aim of this study was to investigate the texture characteristics of altered PAG in episodic migraine (EM) patients based on high resolution brain structural magnetic resonance (MR) images. Materials and Methods: The brain structural MR images were obtained from 18 normal controls (NC), 18 EM patients and 16 chronic migraine (CM) patients using a 3T MR system...
January 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29352123/tumor-tissue-detection-using-blood-oxygen-level-dependent-functional-mri-based-on-independent-component-analysis
#13
Huiyuan Huang, Junfeng Lu, Jinsong Wu, Zhongxiang Ding, Shuda Chen, Lisha Duan, Jianling Cui, Fuyong Chen, Dezhi Kang, Le Qi, Wusi Qiu, Seong-Whan Lee, ShiJun Qiu, Dinggang Shen, Yu-Feng Zang, Han Zhang
Accurate delineation of gliomas from the surrounding normal brain areas helps maximize tumor resection and improves outcome. Blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) has been routinely adopted for presurgical mapping of the surrounding functional areas. For completely utilizing such imaging data, here we show the feasibility of using presurgical fMRI for tumor delineation. In particular, we introduce a novel method dedicated to tumor detection based on independent component analysis (ICA) of resting-state fMRI (rs-fMRI) with automatic tumor component identification...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29340288/7t-mri-subthalamic-nucleus-atlas-for-use-with-3t-mri
#14
Mikhail Milchenko, Scott A Norris, Kathleen Poston, Meghan C Campbell, Mwiza Ushe, Joel S Perlmutter, Abraham Z Snyder
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces motor symptoms in most patients with Parkinson disease (PD), yet may produce untoward effects. Investigation of DBS effects requires accurate localization of the STN, which can be difficult to identify on magnetic resonance images collected with clinically available 3T scanners. The goal of this study is to develop a high-quality STN atlas that can be applied to standard 3T images. We created a high-definition STN atlas derived from seven older participants imaged at 7T...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29325780/longitudinal-atlas-for-normative-human-brain-development-and-aging-over-the-lifespan-using-quantitative-susceptibility-mapping
#15
Yuyao Zhang, Hongjiang Wei, Matthew J Cronin, Naying He, Fuhua Yan, Chunlei Liu
Longitudinal brain atlases play an important role in the study of human brain development and cognition. Existing atlases are mainly based on anatomical features derived from T1-and T2-weighted MRI. A 4D developmental quantitative susceptibility mapping (QSM) atlas may facilitate the estimation of age-related iron changes in deep gray matter nuclei and myelin changes in white matter. To this end, group-wise co-registered QSM templates were generated over various age intervals from age 1-83 years old. Registration was achieved by combining both T1-weighted and QSM images...
January 8, 2018: NeuroImage
https://www.readbyqxmd.com/read/29322586/functional-connectivity-predicts-gender-evidence-for-gender-differences-in-resting-brain-connectivity
#16
Chao Zhang, Chase C Dougherty, Stefi A Baum, Tonya White, Andrew M Michael
Prevalence of certain forms of psychopathology, such as autism and depression, differs between genders and understanding gender differences of the neurotypical brain may provide insights into risk and protective factors. In recent research, resting state functional magnetic resonance imaging (rfMRI) is widely used to map the inherent functional networks of the brain. Although previous studies have reported gender differences in rfMRI, the robustness of gender differences is not well characterized. In this study, we use a large data set to test whether rfMRI functional connectivity (FC) can be used to predict gender and identify FC features that are most predictive of gender...
January 10, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29322076/a-spline-based-regression-parameter-set-for-creating-customized-dartel-mri-brain-templates-from-infancy-to-old-age
#17
Marko Wilke
This dataset contains the regression parameters derived by analyzing segmented brain MRI images (gray matter and white matter) from a large population of healthy subjects, using a multivariate adaptive regression splines approach. A total of 1919 MRI datasets ranging in age from 1-75 years from four publicly available datasets (NIH, C-MIND, fCONN, and IXI) were segmented using the CAT12 segmentation framework, writing out gray matter and white matter images normalized using an affine-only spatial normalization approach...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29313322/comparing-three-dimensional-serial-optical-coherence-tomography-histology-to-mri-imaging-in-the-entire-mouse-brain
#18
Alexandre Castonguay, Joël Lefebvre, Frédéric Lesage, Philippe Pouliot
An automated serial histology setup combining optical coherence tomography (OCT) imaging with vibratome sectioning was used to image eight wild type mouse brains. The datasets resulted in thousands of volumetric tiles resolved at a voxel size of (4.9×4.9×6.5)  μm3 stitched back together to give a three-dimensional map of the brain from which a template OCT brain was obtained. To assess deformation caused by tissue sectioning, reconstruction algorithms, and fixation, OCT datasets were compared to both in vivo and ex vivo magnetic resonance imaging (MRI) imaging...
January 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29278579/sentinel-lymph-node-surgery-in-prostate-cancer-using-magnetic-particles
#19
Alexander Winter, Svenja Engels, Friedhelm Wawroschek
PURPOSE OF REVIEW: Superparamagnetic iron oxide nanoparticles (SPIONs) are tested to identify sentinel lymph nodes (SLNs) to exploit the advantages of targeted pelvic SLN dissection (sPLND), while circumventing the disadvantages of established radioactive labeling. Here we review recent studies about sPLND in prostate cancer (PCa), including the first results of SLN detection using intraprostatic SPION-injection. RECENT FINDINGS: A recent systematic literature review reveals that the diagnostic accuracy of sPLND is comparable with extended PLND (ePLND)...
December 22, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29277858/multi-institutional-survey-on-imaging-practice-patterns-in-pancreatic-ductal-adenocarcinoma
#20
Avinash R Kambadakone, Atif Zaheer, Ott Le, Priya Bhosale, Jeffrey Meier, Alexander R Guimaraes, Zarine Shah, David M Hough, Lorenzo Mannelli, Erik Soloff, Arnold Friedman, Eric Tamm
PURPOSE: To study the practice patterns for performance and interpretation of CT/MRI imaging studies in patients with pancreatic ductal adenocarcinoma (PDAC) at multiple institutions using a survey-based assessment. METHODS: In this study, abdominal radiologists/body imagers on the Society of Abdominal Radiology disease-focused panel for PDAC and from multiple institutions participated in an online survey. The survey was designed to investigate the imaging and reporting practice patterns for PDAC...
December 26, 2017: Abdominal Radiology
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