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https://www.readbyqxmd.com/read/29034221/atypical-small-acinar-proliferation-and-two-or-more-cores-of-high-grade-intraepithelial-neoplasia-on-a-previous-prostate-biopsy-are-significant-predictors-of-cancer-during-a-transperineal-template-guided-saturation-biopsy-aimed-at-sampling-one-core-for-each
#1
Yasushi Nakai, Nobumichi Tanaka, Makito Miyake, Shunta Hori, Yoshihiro Tatsumi, Yosuke Morizawa, Tomomi Fujii, Noboru Konishi, Kiyohide Fujimoto
OBJECTIVE: The objective of this study was to evaluate whether high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical small acinar proliferation (ASAP) predict prostate cancer (PCa) during repeat transperineal template saturation biopsy with a high number of cores per prostate volume in patients with persistent clinical suspicion of PCa who underwent at least one previous negative transrectal ultrasound (TRUS)-guided biopsy. METHODS: We retrospectively evaluated 135 consecutive patients with persistent clinical suspicion of PCa, despite a set of negative TRUS-guided biopsies and increasing prostate-specific antigen levels; abnormal findings on digital rectal examination, TRUS, or magnetic resonance imaging; previous biopsy showing HGPIN; and previous biopsy showing atypical glands...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/29029832/tumour-auto-contouring-on-2d-cine-mri-for-locally-advanced-lung-cancer-a-comparative-study
#2
Martin F Fast, Björn Eiben, Martin J Menten, Andreas Wetscherek, David J Hawkes, Jamie R McClelland, Uwe Oelfke
BACKGROUND AND PURPOSE: Radiotherapy guidance based on magnetic resonance imaging (MRI) is currently becoming a clinical reality. Fast 2d cine MRI sequences are expected to increase the precision of radiation delivery by facilitating tumour delineation during treatment. This study compares four auto-contouring algorithms for the task of delineating the primary tumour in six locally advanced (LA) lung cancer patients. MATERIAL AND METHODS: Twenty-two cine MRI sequences were acquired using either a balanced steady-state free precession or a spoiled gradient echo imaging technique...
October 10, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29021588/robust-fusion-of-diffusion-mri-data-for-template-construction
#3
Zhanlong Yang, Geng Chen, Dinggang Shen, Pew-Thian Yap
Construction of brain templates is generally carried out using a two-step procedure involving registering a population of images to a common space and then fusing the aligned images to form a template. In practice, image registration is not perfect and simple averaging of the images will blur structures and cause artifacts. In diffusion MRI, this is further complicated by intra-voxel inter-subject differences in fiber orientation, fiber configuration, anisotropy, and diffusivity. In this paper, we propose a method to improve the construction of diffusion MRI templates in light of inter-subject differences...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29017799/automated-segmentation-of-abdominal-subcutaneous-adipose-tissue-and-visceral-adipose-tissue-in-obese-adolescent-in-mri
#4
Steve C N Hui, Teng Zhang, Lin Shi, Defeng Wang, Chei-Bing Ip, Winnie C W Chu
PURPOSE: To develop a reliable and reproducible automatic technique to segment and measure SAT and VAT based on MRI. MATERIALS AND METHODS: Chemical-shift water-fat MRI were taken on twelve obese adolescents (mean age: 16.1±0.6, BMI: 31.3±2.3) recruited under the health monitoring program. The segmentation applied a spoke template created using Midpoint Circle algorithm followed by Bresenham's Line algorithm to detect narrow connecting regions between subcutaneous and visceral adipose tissues...
October 7, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28994487/scan-rescan-of-axcaliber-macromolecular-tissue-volume-and-g-ratio-in-the-spinal-cord
#5
Tanguy Duval, Victoria Smith, Nikola Stikov, Eric C Klawiter, Julien Cohen-Adad
PURPOSE: Recent MRI techniques have been introduced that can extract microstructural information in the white matter, such as the density or macromolecular content. Translating quantitative MRI to the clinic raises many challenges in terms of acquisition strategy, modeling of the MRI signal, artifact corrections, and metric extraction (template registration and partial volume effects). In this work, we investigated the scan-rescan repeatability of several quantitative MRI techniques in the human spinal cord...
October 10, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28990264/consistency-of-magnetoencephalographic-functional-connectivity-and-network-reconstruction-using-a-template-versus-native-mri-for-co-registration
#6
Linda Douw, Dagmar Nieboer, Cornelis J Stam, Prejaas Tewarie, Arjan Hillebrand
INTRODUCTION: Studies using functional connectivity and network analyses based on magnetoencephalography (MEG) with source localization are rapidly emerging in neuroscientific literature. However, these analyses currently depend on the availability of costly and sometimes burdensome individual MR scans for co-registration. We evaluated the consistency of these measures when using a template MRI, instead of native MRI, for the analysis of functional connectivity and network topology. METHODS: Seventeen healthy participants underwent resting-state eyes-closed MEG and anatomical MRI...
October 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28980714/-18-f-flortaucipir-tau-pet-distinguishes-established-progressive-supranuclear-palsy-from-controls-and-parkinson-s-disease-a-multicenter-study
#7
Daniel R Schonhaut, Corey T McMillan, Salvatore Spina, Bradford C Dickerson, Andrew Siderowf, Michael D Devous, Richard Tsai, Joseph Winer, David S Russell, Irene Litvan, Erik D Roberson, William W Seeley, Lea T Grinberg, Joel H Kramer, Bruce L Miller, Peter Pressman, Ilya Nasrallah, Suzanne L Baker, Stephen N Gomperts, Keith A Johnson, Murray Grossman, William J Jagust, Adam L Boxer, Gil D Rabinovici
OBJECTIVE: (18) F-flortaucipir (formerly (18) F-AV1451 or (18) F-T807) binds to neurofibrillary tangles in Alzheimer's disease (AD), but tissue studies assessing binding to tau aggregates in progressive supranuclear palsy (PSP) have yielded mixed results. We compared in vivo (18) F-flortaucipir uptake in patients meeting clinical research criteria for PSP (N=33) to normal controls (N=46) and patients meeting criteria for Parkinson's disease (PD, N=26). METHODS: Participants underwent MRI and positron emission tomography for amyloid-β ((11) C-PiB or (18) F-florbetapir) and tau ((18) F-flortaucipir)...
October 5, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28971011/structurofunctional-resting-state-networks-correlate-with-motor-function-in-chronic-stroke
#8
Benjamin T Kalinosky, Reivian Berrios Barillas, Brian D Schmit
PURPOSE: Motor function and recovery after stroke likely rely directly on the residual anatomical connections in the brain and its resting-state functional connectivity. Both structural and functional properties of cortical networks after stroke are revealed using multimodal magnetic resonance imaging (MRI). Specifically, functional connectivity MRI (fcMRI) can extract functional networks of the brain at rest, while structural connectivity can be estimated from white matter fiber orientations measured with high angular-resolution diffusion imaging (HARDI)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28963056/hippocampus-dependent-spatial-learning-is-associated-with-higher-global-cognition-among-healthy-older-adults
#9
Kyoko Konishi, Sam Mckenzie, Nicole Etchamendy, Shumita Roy, Véronique D Bohbot
Cognitive deficits in normal aging have been associated with atrophy of the hippocampus. As such, methods to detect early dysfunction of the hippocampus have become valuable, if not indispensable, to early intervention. The hippocampus is critical for spatial memory and is among the first structures to atrophy with aging. Despite the presence of navigation deficits in aging, few studies have looked at the association between wayfinding ability, navigation strategies, general cognitive function, and hippocampal volume...
September 26, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28962878/targeted-prostate-biopsy-in-the-era-of-active-surveillance
#10
REVIEW
Fuad F Elkhoury, Demetrios N Simopoulos, Leonard S Marks
Targeted prostate biopsy using magnetic resonance imaging (MRI) guidance is improving accuracy of prostate cancer (CaP) diagnosis. This new biopsy technology is especially important for men undergoing active surveillance, improving patient selection for enrollment and enabling precise longitudinal monitoring. MRI/US fusion biopsy allows for three functions not previously possible with US-guided biopsy: targeting of suspicious regions, template-mapping for systematic sampling, and tracking of cancer foci over time...
September 26, 2017: Urology
https://www.readbyqxmd.com/read/28952814/do-mri-structured-reports-for-multiple-sclerosis-contain-adequate-information-for-clinical-decision-making
#11
Francesco Alessandrino, Anna Pichiecchio, Giulia Mallucci, Emanuele Ghione, Alfredo Romani, Roberto Bergamaschi, Stefano Bastianello
OBJECTIVE: Few data are available on how often MRI reports provide sufficient information for clinical decision-making in patients with multiple sclerosis (MS). The aim of this study is to evaluate if structured reporting of MRI in MS contain adequate information for clinical decision-making compared with nonstructured reporting. MATERIALS AND METHODS: Brain and spinal cord MRI reports of patients with suspected or known MS before and after implementation of a structured reporting template were included...
September 27, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28941761/direct-comparison-of-pi-rads-version-2-and-version-1-regarding-interreader-agreement-and-diagnostic-accuracy-for-the-detection-of-clinically-significant-prostate-cancer
#12
Anton S Becker, Alexander Cornelius, Cäcilia S Reiner, Daniel Stocker, Erika J Ulbrich, Borna K Barth, Ashkan Mortezavi, Daniel Eberli, Olivio F Donati
PURPOSE: to simultaneously evaluate interreader agreement and diagnostic accuracy in the of PI-RADS v2 and compare it to v1. METHODS: A total of 67 patients (median age 65.3 y, range 51.2-78.2 y; PSA 6.8μg/L, 0.2-33μg/L) undergoing MRI of the prostate and subsequent transperineal template biopsy within ≤6 months from MRI were included. Four readers from two institutions evaluated the likelihood of prostate cancer using PI-RADS v1 and v2 in two separate reading sessions ≥3 months apart...
September 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28935163/optimising-the-diagnosis-of-prostate-cancer-in-the-era-of-multiparametric-magnetic-resonance-imaging-a-cost-effectiveness-analysis-based-on-the-prostate-mr-imaging-study-promis
#13
Rita Faria, Marta O Soares, Eldon Spackman, Hashim U Ahmed, Louise C Brown, Richard Kaplan, Mark Emberton, Mark J Sculpher
BACKGROUND: The current recommendation of using transrectal ultrasound-guided biopsy (TRUSB) to diagnose prostate cancer misses clinically significant (CS) cancers. More sensitive biopsies (eg, template prostate mapping biopsy [TPMB]) are too resource intensive for routine use, and there is little evidence on multiparametric magnetic resonance imaging (MPMRI). OBJECTIVE: To identify the most effective and cost-effective way of using these tests to detect CS prostate cancer...
September 18, 2017: European Urology
https://www.readbyqxmd.com/read/28927782/development-and-internal-validation-of-prediction-models-for-biochemical-failure-and-composite-failure-after-focal-salvage-high-intensity-focused-ultrasound-for-local-radiorecurrent-prostate-cancer-presentation-of-risk-scores-for-individual-patient-prognoses
#14
Max Peters, Abi Kanthabalan, Taimur T Shah, Neil McCartan, Caroline M Moore, Manit Arya, Jochem R van der Voort van Zyp, Marinus A Moerland, Richard G Hindley, Mark Emberton, Hashim U Ahmed
PURPOSE: Patient selection for focal salvage remains difficult. Therefore, we developed and internally validated prediction models for biochemical failure (BF) and a composite endpoint (CE) following focal salvage high intensity focused ultrasound (HIFU) for radiorecurrent prostate cancer. MATERIALS AND METHODS: A prospective HIFU registry identified 150 cases (November 2006-August 2015). Recurrence was assessed with multiparametric magnetic resonance imaging (MRI) combined with template prostate mapping biopsies, targeted biopsies, or systematic transrectal ultrasound-guided biopsies...
September 15, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28926131/region-specific-impairment-of-the-cervical-spinal-cord-sc-in-amyotrophic-lateral-sclerosis-a-preliminary-study-using-sc-templates-and-quantitative-mri-diffusion-tensor-imaging-inhomogeneous-magnetization-transfer
#15
Henitsoa Rasoanandrianina, Aude-Marie Grapperon, Manuel Taso, Olivier M Girard, Guillaume Duhamel, Maxime Guye, Jean-Philippe Ranjeva, Shahram Attarian, Annie Verschueren, Virginie Callot
In this preliminary study, our objective was to investigate the potential of high-resolution anatomical imaging, diffusion tensor imaging (DTI) and conventional/inhomogeneous magnetization transfer imaging [magnetization transfer (MT)/inhomogeneous magnetization transfer (ihMT)] at 3 T, analyzed with template-extracted regions of interest, to measure the atrophy and structural changes of white (WM) and gray (GM) matter spinal cord (SC) occurring in patients with amyotrophic lateral sclerosis (ALS). Ten patients with ALS and 20 age-matched healthy controls were recruited...
September 19, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28924555/early-changes-in-brain-structure-correlate-with-language-outcomes-in-children-with-neonatal-encephalopathy
#16
Kevin A Shapiro, Hosung Kim, Maria Luisa Mandelli, Elizabeth E Rogers, Dawn Gano, Donna M Ferriero, A James Barkovich, Maria Luisa Gorno-Tempini, Hannah C Glass, Duan Xu
Global patterns of brain injury correlate with motor, cognitive, and language outcomes in survivors of neonatal encephalopathy (NE). However, it is still unclear whether local changes in brain structure predict specific deficits. We therefore examined whether differences in brain structure at 6 months of age are associated with neurodevelopmental outcomes in this population. We enrolled 32 children with NE, performed structural brain MR imaging at 6 months, and assessed neurodevelopmental outcomes at 30 months...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28917660/stereotaxic-18-f-fdg-pet-and-mri-templates-with-three-dimensional-digital-atlas-for-statistical-parametric-mapping-analysis-of-tree-shrew-brain
#17
Qi Huang, Binbin Nie, Chen Ma, Jing Wang, Tianhao Zhang, Shaofeng Duan, Shang Wu, Shengxiang Liang, Panlong Li, Hua Liu, Hua Sun, Jiangning Zhou, Lin Xu, Baoci Shan
BACKGROUND: Tree shrews are proposed as an alternative animal model to nonhuman primates due to their close affinity to primates. Neuroimaging techniques are widely used to study brain functions and structures of humans and animals. However, tree shrews are rarely applied in neuroimaging field partly due to the lack of available species specific analysis methods. NEW METHOD: In this study, 10 PET/CT and 10 MRI images of tree shrew brain were used to construct PET and MRI templates; based on histological atlas we reconstructed a three-dimensional digital atlas with 628 structures delineated; then the digital atlas and templates were aligned into a stereotaxic space...
September 14, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28902466/learning-based-deformable-registration-for-infant-mri-by-integrating-random-forest-with-auto-context-model
#18
Lifang Wei, Xiaohuan Cao, Zhensong Wang, Yaozong Gao, Shunbo Hu, Li Wang, Guorong Wu, Dinggang Shen
PURPOSE: Accurately analyzing the rapid structural evolution of human brain in the first year of life is a key step in early brain development studies, which requires accurate deformable image registration. However, due to 1) dynamic appearance and 2) large anatomical changes, very few methods in the literature can work well for the registration of two infant brain MR images acquired at two arbitrary development phases, such as birth and one-year-old. METHODS: To address these challenging issues, we propose a learning-based registration method, which can handle the anatomical structures and the appearance changes between the two infant brain MR images with possible time gap...
September 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28860982/using-large-scale-statistical-chinese-brain-template-chinese2020-in-popular-neuroimage-analysis-toolkits
#19
Lin Shi, Peipeng Liang, Yishan Luo, Kai Liu, Vincent C T Mok, Winnie C W Chu, Defeng Wang, Kuncheng Li
Given that the morphology of Chinese brains statistically differs from that of Caucasian, there is an urgent need to develop a Chinese brain template for neuroimaging studies in Chinese populations. Based on a multi-center dataset, we developed a statistical Chinese brain template, named as Chinese2020 (Liang et al., 2015). This new Chinese brain atlas has been validated in brain normalization and segmentation for anatomical Magnetic Resonance Imaging (MRI) studies, and is publicly available at http://www.chinese-brain-atlases...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28856067/application-of-dendrimer-based-nanoparticles-in-glioma-imaging
#20
Sunalee Gonawala, Meser M Ali
Dendritic polymers or dendrimers present an alternate template for the development of nanoparticulate-based drug delivery and imaging systems. The smaller size (~7-12 nm) of dendrimers have the advantage over the other particles, because its smaller size can possibly improve tumor penetration and the inclusion of tumor specific drug release mechanisms. A Paramagnetic Chemical Exchange Saturation Transfer (PARACEST) MRI contrast agent, Eu-DOTA-Gly4 or a clinical relevant Gd-DOTA was conjugated on the surface of a G5 PAMAM dendrimer...
June 2017: Journal of Nanomedicine & Nanotechnology
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