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Hjalte C R Sass, Rehannah Borup, Mikkel Alanin, Finn Cilius Nielsen, Per Cayé-Thomasen
The objective of this study was to determine global gene expression in relation to Vestibular schwannomas (VS) growth rate and to identify signal transduction pathways and functional molecular networks associated with growth. Repeated magnetic resonance imaging (MRI) prior to surgery determined tumor growth rate. Following tissue sampling during surgery, mRNA was extracted from 16 sporadic VS. Double stranded cDNA was synthesized from the mRNA and used as template for in vitro transcription reaction to synthesize biotin-labeled antisense cRNA, which was hybridized to Affymetrix HG-U133A arrays and analyzed by dChip software...
October 17, 2016: Journal of Neuro-oncology
Tamilmani Vairapperumal, Ariya Saraswathy, Jayasree S Ramapurath, Sreeram Kalarical Janardhanan, Nair Balachandran Unni
Tetragonal (t)-LaVO4 has turned out to be a potential host for luminescent materials. Synthesis of t-LaVO4 till date has been based on chelating effect of EDTA making it not ideal for bioimaging applications. An alternative was proposed by us through the use of catechin. In recent times there is interest for new MRI contrast agents that can through appropriate doping function both as MRI contrast and optical/upconversion materials. It is generally believed that under appropriate doping, t-LaVO4 would be a better upconversion material than monoclinic (m)-LaVO4...
October 18, 2016: Scientific Reports
Hosung Kim, Ji-Hoon Kim, Katherine L Possin, Joseph Winer, Michael D Geschwind, Duan Xu, Christopher P Hess
In patients with premotor Huntington's disease (pmHD), literature has reported decreases in caudate volume. However, the regional vulnerability of the caudate nucleus to pmHD remains to be clarified. We aimed to determine whether regional structural damage of the caudate nucleus was present in pmHD and was correlated with clinical profile using a surface-based morphometric technique applied to T1-weighted MRI. The study cohort consisted of 14 volunteers with genetically confirmed pmHD (6 males; 41.8 ± 13...
October 11, 2016: Brain Imaging and Behavior
Bonnie Alexander, Andrea L Murray, Wai Yen Loh, Lillian G Matthews, Chris Adamson, Richard Beare, Jian Chen, Claire E Kelly, Sandra Rees, Simon K Warfield, Peter J Anderson, Lex W Doyle, Alicia J Spittle, Jeanie L Y Cheong, Marc L Seal, Deanne K Thompson
Investigating neonatal brain structure and function can offer valuable insights into behaviour and cognition in healthy and clinical populations; both at term age, and longitudinally in comparison with later time points. Parcellated brain atlases for adult populations are readily available, however warping infant data to adult template space is not ideal due to morphological and tissue differences between these groups. Several parcellated neonatal atlases have been developed, although there remains strong demand for manually parcellated ground truth data with detailed cortical definition...
October 7, 2016: NeuroImage
Nikola K Kasabov, Maryam Gholami Doborjeh, Zohreh Gholami Doborjeh
This paper introduces a new methodology for dynamic learning, visualization, and classification of functional magnetic resonance imaging (fMRI) as spatiotemporal brain data. The method is based on an evolving spatiotemporal data machine of evolving spiking neural networks (SNNs) exemplified by the NeuCube architecture [1]. The method consists of several steps: mapping spatial coordinates of fMRI data into a 3-D SNN cube (SNNc) that represents a brain template; input data transformation into trains of spikes; deep, unsupervised learning in the 3-D SNNc of spatiotemporal patterns from data; supervised learning in an evolving SNN classifier; parameter optimization; and 3-D visualization and model interpretation...
October 6, 2016: IEEE Transactions on Neural Networks and Learning Systems
Benjamin De Leener, Simon Lévy, Sara M Dupont, Vladimir S Fonov, Nikola Stikov, D Louis Collins, Virginie Callot, Julien Cohen-Adad
For the past 25 years, the field of neuroimaging has witnessed the development of several software packages for processing multi-parametric magnetic resonance imaging (mpMRI) to study the brain. These software packages are now routinely used by researchers and clinicians, and have contributed to important breakthroughs for the understanding of brain anatomy and function. However, no software package exists to process mpMRI data of the spinal cord. Despite the numerous clinical needs for such advanced mpMRI protocols (multiple sclerosis, spinal cord injury, cervical spondylotic myelopathy, etc...
October 5, 2016: NeuroImage
Long Xie, John B Pluta, Sandhitsu R Das, Laura E M Wisse, Hongzhi Wang, Lauren Mancuso, Dasha Kliot, Brian B Avants, Song-Lin Ding, José V Manjón, David A Wolk, Paul A Yushkevich
RATIONALE: The human perirhinal cortex (PRC) plays critical roles in episodic and semantic memory and visual perception. The PRC consists of Brodmann areas 35 and 36 (BA35, BA36). In Alzheimer's disease (AD), BA35 is the first cortical site affected by neurofibrillary tangle pathology, which is closely linked to neural injury in AD. Large anatomical variability, manifested in the form of different cortical folding and branching patterns, makes it difficult to segment the PRC in MRI scans...
October 1, 2016: NeuroImage
Andrew Lang, Aaron Carass, Bruno M Jedynak, Sharon D Solomon, Peter A Calabresi, Jerry L Prince
As optical coherence tomography (OCT) has increasingly become a standard modality for imaging the retina, automated algorithms for processing OCT data have become necessary to do large scale studies looking for changes in specific layers. To provide accurate results, many of these algorithms rely on the consistency of layer intensities within a scan. Unfortunately, OCT data often exhibits inhomogeneity in a given layer's intensities, both within and between images. This problem negatively affects the performance of segmentation algorithms and little prior work has been done to correct this data...
April 2016: Proceedings of the IEEE International Symposium on Biomedical Imaging: from Nano to Macro
Dorothy A Sippo, Robyn L Birdwell, Katherine P Andriole, Sughra Raza
No abstract text is available yet for this article.
September 24, 2016: Journal of the American College of Radiology: JACR
Qianjin Feng, Yujia Zhou, Xueli Li, Yingjie Mei, Zhentai Lu, Yu Zhang, Yanqiu Feng, Yaqin Liu, Wei Yang, Wufan Chen
A technical challenge in the registration of dynamic contrast-enhanced magnetic resonance (DCE-MR) imaging in the liver is intensity variations caused by contrast agents. Such variations lead to the failure of the traditional intensity-based registration method. To address this problem, a manifold-based registration framework for liver DCE-MR time series is proposed. We assume that liver DCE-MR time series are located on a low-dimensional manifold and determine intrinsic similarities between frames. Based on the obtained manifold, the large deformation of two dissimilar images can be decomposed into a series of small deformations between adjacent images on the manifold through gradual deformation of each frame to the template image along the geodesic path...
September 29, 2016: Scientific Reports
Sara M Dupont, Benjamin De Leener, Manuel Taso, Arnaud Le Troter, Nikola Stikov, Virginie Callot, Julien Cohen-Adad
: The spinal cord white and gray matter can be affected by various pathologies such as multiple sclerosis, amyotrophic lateral sclerosis or trauma. Being able to precisely segment the white and gray matter could help with MR image analysis and hence be useful in further understanding these pathologies, and helping with diagnosis/prognosis and drug development. Up to date, white/gray matter segmentation has mostly been done manually, which is time consuming, induces a bias related to the rater and prevents large-scale multi-center studies...
September 20, 2016: NeuroImage
James Dormer, Xulei Qin, Ming Shen, Silun Wang, Xiaodong Zhang, Rong Jiang, Mary B Wagner, Baowei Fei
Accurate extraction of cardiac fiber orientation from diffusion tensor imaging is important for determining heart structure and function. However, the acquisition of magnetic resonance (MR) diffusion tensor images is costly and time consuming. By comparison, cardiac ultrasound imaging is rapid and relatively inexpensive, but it lacks the capability to directly measure fiber orientations. In order to create a detailed heart model from ultrasound data, a three-dimensional (3D) diffusion tensor imaging (DTI) with known fiber orientations can be registered to an ultrasound volume through a geometric mask...
February 27, 2016: Proceedings of SPIE
Harbir S Sidhu, Salvatore Benigno, Balaji Ganeshan, Nikos Dikaios, Edward W Johnston, Clare Allen, Alex Kirkham, Ashley M Groves, Hashim U Ahmed, Mark Emberton, Stuart A Taylor, Steve Halligan, Shonit Punwani
OBJECTIVES: To evaluate multiparametric-MRI (mpMRI) derived histogram textural-analysis parameters for detection of transition zone (TZ) prostatic tumour. METHODS: Sixty-seven consecutive men with suspected prostate cancer underwent 1.5T mpMRI prior to template-mapping-biopsy (TPM). Twenty-six men had 'significant' TZ tumour. Two radiologists in consensus matched TPM to the single axial slice best depicting tumour, or largest TZ diameter for those with benign histology, to define single-slice whole TZ-regions-of-interest (ROIs)...
September 12, 2016: European Radiology
Arnauld Villers, Philippe Puech, Vincent Flamand, Georges-Pascal Haber, Mihir M Desai, Sebastien Crouzet, Xavier Leroy, Sameer Chopra, Laurent Lemaitre, Adil Ouzzane, Inderbir S Gill
BACKGROUND: Focal ablative therapy may be a suboptimal option for anterior prostate cancers (APCs) reaching the prostate apex due to concerns for thermal injury to the external sphincter. OBJECTIVE: To explore the technical feasibility of anterior partial prostatectomy (APP) for isolated APCs detected by magnetic resonance imaging (MRI), and to report short-term oncologic and functional outcomes. DESIGN, SETTING, AND PARTICIPANTS: Following institutional review board approval, over an 8-yr period (2008-2015) 17 consenting patients were enrolled in a prospective single-arm single-center Innovation, Development, Exploration, Assessment, Long-term (IDEAL) phase 2a study...
September 6, 2016: European Urology
Athar Haroon, Hashim U Ahmed, Paul Cathcart, Ahmad Almuhaideb, Irfan Kayani, John Dickson, Alex Kirkham, Alex Freeman, Mark Emberton, Jamshed Bomanji
OBJECTIVE: The objective of this study was to detect clinically significant and insignificant prostate cancer on (18)F-fluoroethylcholine (FECH) PET/CT and to correlate findings with transperineal template-guided prostate mapping (TPM) biopsy. SUBJECTS AND METHODS: Fifty-six lobes of the prostate were analyzed in 28 men who underwent FECH PET/CT and TPM. Whole-body images and pelvic images were acquired at 60 and 90 minutes after tracer administration. FECH PET/CT findings were correlated with TPM...
September 9, 2016: AJR. American Journal of Roentgenology
David A Woodrum, Krzysztof R Gorny, Bernadette Greenwood, Lance A Mynderse
Prostate cancer is the most commonly diagnosed noncutaneous cancer and second-leading cause of death in men. Many patients with clinically organ-confined prostate cancer undergo definitive, curative treatment of the whole gland with either radical prostatectomy or radiation therapy. However, many men are reluctant to take the definitive step due to potential morbidity associated with either therapy. A growing interest in active surveillance or focal therapy has emerged as realistic alternatives for many patients...
September 2016: Seminars in Interventional Radiology
Aurélien Massire, Manuel Taso, Pierre Besson, Maxime Guye, Jean-Philippe Ranjeva, Virginie Callot
Quantitative MRI techniques have the potential to characterize spinal cord tissue impairments occurring in various pathologies, from both microstructural and functional perspectives. By enabling very high image resolution and enhanced tissue contrast, ultra-high field imaging may offer further opportunities for such characterization. In this study, a multi-parametric high-resolution quantitative MRI protocol is proposed to characterize in vivo the human cervical spinal cord at 7T. Multi-parametric quantitative MRI acquizitions including T1, T2(*) relaxometry mapping and axial diffusion MRI were performed on ten healthy volunteers with a whole-body 7T system using a commercial prototype coil-array dedicated to cervical spinal cord imaging...
August 26, 2016: NeuroImage
Colin Reveley, Audrūnas Gruslys, Frank Q Ye, Daniel Glen, Jason Samaha, Brian E Russ, Ziad Saad, Anil K Seth, David A Leopold, Kadharbatcha S Saleem
We present a new 3D template atlas of the anatomical subdivisions of the macaque brain, which is based on and aligned to the magnetic resonance imaging (MRI) data set and histological sections of the Saleem and Logothetis atlas. We describe the creation and validation of the atlas that, when registered with macaque structural or functional MRI scans, provides a straightforward means to estimate the boundaries between architectonic areas, either in a 3D volume with different planes of sections, or on an inflated brain surface (cortical flat map)...
August 27, 2016: Cerebral Cortex
Morteza Mahmoudi, Mingming Zhao, Yuka Matsuura, Sophie Laurent, Phillip C Yang, Daniel Bernstein, Pilar Ruiz-Lozano, Vahid Serpooshan
Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium. By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch...
2016: BioImpacts: BI
Bihua Ye, Xueshi Luo, Zhiwen Li, Caiping Zhuang, Lihua Li, Lu Lu, Shan Ding, Jinhuan Tian, Changren Zhou
Collagen biomineralization is regulated by complicated interactions between the collagen matrix and non-collagenous extracellular proteins. Here, the use of sodium tripolyphosphate to simulate the templating functional motif of the C-terminal fragment of non-collagenous proteins is reported, and a low molecular weight polyacrylic acid served as a sequestration agent to stabilize amorphous calcium phosphate into nanoprecursors. Self-assembled collagen fibrils served as a fixed template for achieving rapid biomimetic mineralization in vitro...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
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