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prp sports medicine

Yiqin Zhou, James H-C Wang
Platelet-Rich Plasma (PRP) has been widely used in orthopaedic surgery and sport medicine to treat tendon injuries. However, the efficacy of PRP treatment for tendinopathy is controversial. This paper focuses on reviewing the basic science studies on PRP performed under well-controlled conditions. Both in vitro and in vivo studies describe PRP's anabolic and anti-inflammatory effects on tendons. While some clinical trials support these findings, others refute them. In this review, we discuss the effectiveness of PRP to treat tendon injuries with evidence presented in basic science studies and the potential reasons for the controversial results in clinical trials...
2016: BioMed Research International
Ryan A Mlynarek, Andrew W Kuhn, Asheesh Bedi
The use of platelet-rich plasma (PRP) injections in the treatment of musculoskeletal conditions has become more prevalent in recent years. Current literature has exhibited that PRP injections are relatively safe and can potentially accelerate or augment the soft tissue healing process. This review presents the most current literature update on the use of PRP in the treatment of rotator cuff tears, osteoarthritis of the knee, ulnar collateral ligament tears, lateral epicondylitis, hamstring injuries, and Achilles tendinopathy...
July 2016: American Journal of Orthopedics
Masoomeh Gholami, Hamid Ravaghi, Masoud Salehi, Amirhosein Abedi Yekta, Shila Doaee, Ebrahim Jaafaripooyan
INTRODUCTION: In recent years, platelet rich plasma (PRP) has been receiving increasing attention for the treatment of soft tissue injuries. These numerous applications have raised a great deal of questions and debate about the effectiveness of this method. This study aimed to determine the efficacy of PRP in improving sports injuries and subsequently throw some light on these controversies. METHODS: A systematic review of the literature and meta-analysis of results were undertaken...
May 2016: Electronic Physician
Babu Singh, Lynne J Goldberg
Platelet-rich plasma (PRP) is a solution derived from whole blood that is enriched in the platelet fraction. Platelets serve as a reservoir of growth factors and cytokines. When platelets are activated in vivo, signaling molecules are released into the immediate microenvironment and activate receptors for various pathways. Historically, PRP has been applied to wound beds to promote healing of complex wounds. Over the last decade, it has served as a valuable therapeutic tool in various specialties such as maxillofacial surgery, plastic surgery, orthopedics and sports medicine...
August 2016: American Journal of Clinical Dermatology
Maria Fernanda S Reghini, Carlos Ramires Neto, Lorenzo G Segabinazzi, Maria Manoela B Castro Chaves, Camila de Paula F Dell'Aqua, Maria Clara C Bussiere, José Antonio Dell'Aqua, Frederico O Papa, Marco Antonio Alvarenga
Degenerative changes of the endometrium are directly related to age and fertility in mares. Chronic degenerative endometritis (CDE) is correlated with uterine fluid retention and reduced ability to clear uterine inflammation. Recent research in the areas of equine surgery and sports medicine has shown that platelet-rich plasma (PRP) treatment acts as an immunomodulator of the inflammatory response. Therefore, the aim of this study was to determine if the uterine infusion of PRP could modulate the local inflammatory response and modify the intrauterine NO concentrations after artificial insemination (AI) in both normal mares and those with CDE...
July 15, 2016: Theriogenology
Yannick Guillodo, Gwénaelle Madouas, Thomas Simon, Hermine Le Dauphin, Alain Saraux
PURPOSE: hamstring injury is the most common musculoskeletal disorder and one of the main causes of missed sporting events. Shortening the time to return to play (TTRTP) is a priority for athletes and sports medicine practitioners. HYPOTHESIS: platelet-rich plasma (PRP) injection at the site of severe acute hamstring injury increases the healing rate and shortens the TTRTP. STUDY DESIGN: Cohort study. METHODS: all patients with ultrasonography and MRI evidence of severe acute hamstring injury between January 2012 and March 2014 were offered PRP treatment...
October 2015: Muscles, Ligaments and Tendons Journal
Kade L Paterson, Melissa Nicholls, Kim L Bennell, Dan Bates
BACKGROUND: Improvements in knee osteoarthritis (OA) symptoms with platelet-rich plasma (PRP) have been attributed to its ability to modify intra-articular inflammatory processes. Photo-activation of peripheral blood also improves inflammatory mediators associated with OA, however combined photo-activated PRP (PA-PRP) has not been investigated. This pilot study assessed the feasibility, safety and symptomatic and functional change following injections of PA-PRP compared to hyaluronic acid (HA) in people with knee osteoarthritis (OA)...
2016: BMC Musculoskeletal Disorders
Marni Wesner, Terry Defreitas, Heather Bredy, Louisa Pothier, Ziling Qin, Ashley B McKillop, Douglas P Gross
OBJECTIVE: This pilot study aimed to inform future research evaluating the effectiveness of Platelet Rich Plasma (PRP) injection for tendinopathy. DESIGN: Randomized control trial (RCT) and synchronous observational cohort studies. For the RCT, consecutive consenting patients treated at an academic sports medicine clinic were randomly assigned to either a PRP or placebo control group. SETTING: The Glen Sather Sport Medicine Clinic, Edmonton, Canada...
2016: PloS One
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