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prp in orthopedics

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https://www.readbyqxmd.com/read/29862995/an-update-tissue-engineered-nerve-grafts-for-the-repair-of-peripheral-nerve-injuries
#1
Nitesh P Patel, Kristopher A Lyon, Jason H Huang
Peripheral nerve injuries (PNI) are caused by a range of etiologies and result in a broad spectrum of disability. While nerve autografts are the current gold standard for the reconstruction of extensive nerve damage, the limited supply of autologous nerve and complications associated with harvesting nerve from a second surgical site has driven groups from multiple disciplines, including biomedical engineering, neurosurgery, plastic surgery, and orthopedic surgery, to develop a suitable or superior alternative to autografting...
May 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29803179/platelet-rich-plasma-stromal-vascular-fraction-and-autologous-conditioned-serum-in-treatment-of-knee-osteoarthritis
#2
REVIEW
Ali Fotouhi, Arash Maleki, Sanam Dolati, Ali Aghebati-Maleki, Leili Aghebati-Maleki
Osteoarthritis (OA) is a multifactorial chronic disease, causing several problems on patients, hygiene and community care systems. Conventional therapies, such as non-pharmacological mediations, systemic drug treatment and intra-articular therapies are applying previously; however, controlling and management approaches of the disease mainly remain insufficient. Injections of intra-articular therapies directly into the joint evade conservative obstacles to joint entry, rise bioavailability and minor systemic toxicity...
August 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29736577/prp-therapy
#3
Ibrahim Fatih Cengiz, J Miguel Oliveira, Rui L Reis
Osteochondral lesions remain as a clinical challenge despite the advances in orthopedic regenerative strategies. Biologics, in particular, platelet-rich plasma, has been applied for the reparative and regenerative effect in many tissues, and osteochondral tissue is not an exception. Platelet-rich plasma is an autologous concentrate prepared from the collected blood; thus, this safe application is free of immune response or risk of transmission of disease. It has a high potential to promote regeneration, thanks to its content, and can be applied alone or can reinforce a tissue engineering strategy...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29581613/intra-articular-platelet-rich-plasma-prp-injections-for-treating-knee-pain-associated-with-osteoarthritis-of-the-knee-in-the-japanese-population-a-phase-i-and-iia-clinical-trial
#4
Yu Taniguchi, Tomokazu Yoshioka, Akihiro Kanamori, Katsuya Aoto, Hisashi Sugaya, Masashi Yamazaki
Intra-articular platelet-rich plasma (PRP) injection has been found to be effective for treating osteoarthritis in patients from Western countries; however, the safety and efficacy of PRP have not been sufficiently investigated in Japanese patients. The present study aimed to evaluate the safety and feasibility of intra-articular PRP injection in Japanese patients with knee osteoarthritis. PRP without white blood cells was prepared using a single-spin centrifuge (PRGF-Endoret; BTI Biotechnology Institute, Vitoria, Spain)...
February 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29556269/leukocyte-depletion-does-not-affect-the-in-vitro-healing-ability-of-platelet-rich-plasma
#5
Ilaria Giusti, Marianna Di Francesco, Sandra D'Ascenzo, Paola Palumbo, Anna Rughetti, Luigi Dell'Orso, Paola Annunziata Varasano, Gabriella Lucidi Pressanti, Vincenza Dolo
The clinical use of platelet-rich plasma (PRP) containing or deprived of leukocytes remains a subject of debate and a controversial issue. It is not yet clear whether leukocyte content has a positive or negative effect on tissue healing processes. Several studies, conducted mainly in the orthopedic field, support the use of leukocyte-poor (LP) PRP, whereas other studies have not identified any significant differences between the use of LP and leukocyte-rich PRP. In the present study, the role of leukocytes contained in PRP was assessed to verify their in vitro effect on fibroblasts and endothelial cells, which have a leading role in the biological processes associated with wound healing (including angiogenesis and matrix remodeling)...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29451945/the-effects-of-platelet-rich-plasma-and-activated-collagen-on-wound-healing-in-primary-total-joint-arthroplasty
#6
David C Evans, Bruce G Evans
Wound healing remains a concern in primary total joint arthroplasty, given the risk of deep infections arising from hematomas, wound separations, and superficial infections. If wound additives can prevent these early complications, their universal application would be cost-effective. This study examined whether 2 wound additives, platelet-rich plasma (PRP) and activated collagen, would improve postoperative wound healing and reduce complications in primary total joint arthroplasty. A prospective, randomized controlled study was conducted using 3 cohorts with 30 patients each (group 1: PRP; group 2: activated collagen; and group 3: control)...
March 1, 2018: Orthopedics
https://www.readbyqxmd.com/read/29189707/management-and-effect-of-platelet-rich-plasma-on-wound-healing-small-reality-of-oglio-po-hospital
#7
Fioralba Follo, Dario Oliver Dejana, Marzia Belletti, Nicolina Bongiovanni, Giuseppina Scarpa, Patrizia Pezzali, Sandra Borsi, Laura Sanfilippo, Nadia Lusetti, Luigi Zaini, Patrizia Loritto, Francesco Pogliacomi, Alessio Pedrazzini
Platelet Rich Plasma (PRP) represents a relatively new approach in regenerative medicine. Its use is increasing in the treatment of a variety of orthopedic conditions, such as the management of acute wounds, chronic non-healing lesions, acceleration of bone formation, tendinopathy and chondropathy. The Orthopaedic Unit at Oglio Po Hospital uses PRP Gel in wound care since 2008. More than 70 patients have been treated with this procedure. The aim of this study is to show our patients outcome. We present 3 cases of severe traumatic wound treated with our PRP protocol...
November 30, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29183822/treatment-of-aseptic-tibial-shaft-non-union-without-bone-defect
#8
REVIEW
M Tall
Non-union is incomplete consolidation of a fracture, without effective formation of a uniting callus. Despite better understanding of the physiology of bone consolidation, management of tibial non-union remains a challenge for orthopedic surgeons. Several treatments have been developed in recent decades, and we now have a range of techniques, with indications based on type of non-union, prior treatments, available equipment, and the surgeon's experience. Firstly, there are surgical techniques such as osteo-periosteal decortication, cancellous iliac graft, or inter-tibiofibular graft...
February 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29125132/chitosan-inhibits-platelet-mediated-clot-retraction-increases-platelet-derived-growth-factor-release-and-increases-residence-time-and-bioactivity-of-platelet-rich-plasma-in-vivo
#9
Gabrielle Deprés-Tremblay, Anik Chevrier, Nicolas Tran-Khanh, Monica Nelea, Michael D Buschmann
Platelet-rich plasma (PRP) has been used to treat different orthopedic conditions, however, the clinical benefits of using PRP remain uncertain. Chitosan (CS)-PRP implants have been shown to improve meniscus, rotator cuff and cartilage repair in pre-clinical models. The purpose of this current study was to investigate in vitro and in vivo mechanisms of action of CS-PRP implants. Freeze-dried formulations containing 1% (w/v) CS (80% degree of deacetylation and number average molar mass 38 kDa), 1% (w/v) trehalose as a lyoprotectant and 42...
November 10, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29095303/platelet-rich-plasma-as-a-treatment-for-plantar-fasciitis-a-meta-analysis-of-randomized-controlled-trials
#10
REVIEW
Wei-Yi Yang, Yan-Hong Han, Xue-Wei Cao, Jian-Ke Pan, Ling-Feng Zeng, Jiong-Tong Lin, Jun Liu
BACKGROUND: Recently, platelet-rich plasma (PRP) has been used as an alternative therapy for plantar fasciitis (PF) to reduce heel pain and improve functional restoration. We evaluated the current evidence concerning the efficacy and safety of PRP as a treatment for PF compared with the efficacy and safety of steroid treatments. METHODS: Databases (PubMed, EMBASE, and The Cochrane Library) were searched from their establishment to January 30, 2017, for randomized controlled trials (RCTs) comparing PRP with steroid injections as treatments for PF...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28990574/an-evidence-based-evaluation-on-the-use-of-platelet-rich-plasma-in-orthopedics-a-review-of-the-literature
#11
Nasir Hussain, Herman Johal, Mohit Bhandari
Within orthopedics, the use of platelet-rich plasma (PRP) has been rapidly increasing in popularity, however, its true effectiveness has yet to be fully established. Several studies find that injecting PRP to the site of injury does not provide any significant benefit with respect to clinical outcomes; however, many others report the contrary. Due to the conflicting evidence and multiple meta-analyses conducted on the topic, a literature review of high-quality evidence on the use of PRP for common orthopaedic conditions was performed...
2017: SICOT-J
https://www.readbyqxmd.com/read/28887865/platelet-rich-plasma-the-ultimate-secret-for-youthful-skin-elixir-and-hair-growth-triggering
#12
REVIEW
Ebtisam Elghblawi
The clinical application of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors that are released from alpha-granule of the concentrated platelets and in the secretion of proteins which are able to capitalize on the healing process at the cellular level. It has been invented to restore the natural beauty by starting the natural rejuvenation process of the skin and aiming to make it function as a younger one and to keep the skin youthful and maintain it. Besides that, it is also emerged to include hairs as a new injectable procedure to enable stimulating hair growth locally and topically; preventing its fall; improving hair shaft, hair stem, and its caliber; increasing its shine, vitality, and pliability; and declining hair splitting and breakage...
September 8, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28667397/delayed-union-of-humeral-shaft-fractures-comparison-of-autograft-with-and-without-platelet-rich-plasma-treatment-a-randomized-single-blinded-clinical-trial
#13
Carlos Acosta-Olivo, Abiel Garza-Borjon, Mario Simental-Mendia, Felix Vilchez-Cavazos, Yadira Tamez-Mata, Victor Peña-Martinez
INTRODUCTION: Despite an adequate orthopedic treatment with functional bracing, some patients develop a delayed union in humeral shaft fractures. The objective of the present study was to determine the bone consolidation time among patients with delayed union of diaphyseal humeral fractures who were managed with locking compression plate (LCP) fixation combined with an iliac crest autograft using platelet-rich plasma (PRP) as a co-adjuvant. MATERIALS AND METHODS: This study was a controlled, randomized, experimental, longitudinal, comparative, prospective, blind clinical trial...
September 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28467589/a-comparison-of-the-effects-of-platelet-rich-plasma-and-demineralized-bone-matrix-on-critical-bone-defects-an-experimental-study-on-rats
#14
Egemen Turhan, Mustafa Kemal Akça, Ahmet Bayar, Murat Songür, Selçuk Keser, Mahmut Nedim Doral
BACKGROUND: Delayed union of fractured bone is one of the main problems of orthopedics and traumatology practice. It was hypothesized that the beneficial effects of allogeneic platelet-rich plasma (PRP) would be valuable in the treatment of segmental bone defects. This study is a comparison of the effects of demineralized bone matrix (DBM) and PRP in a segmental bone defect model. METHODS: Total of 48 Wistar albino rats were separated into 4 groups. Segmental bone defect was created at right radius diaphysis in all specimens using dorsal approach...
March 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28433472/the-influence-of-platelet-rich-plasma-on-synovial-fluid-volumes-protein-concentrations-and-severity-of-pain-in-patients-with-knee-osteoarthritis
#15
Carl P C Chen, Chih-Hsiu Cheng, Chih-Chin Hsu, Hsin-Chin Lin, Yi-Rong Tsai, Jean-Lon Chen
Knee pain is commonly seen in orthopedic and rehabilitation outpatient clinical settings. Patients with knee osteoarthritis (OA) are often complicated with joint soreness, swelling, weakness, and pain. These complaints are often caused by the excessive amount of synovial fluid (SF) accumulated in the bursae around the knee joint. This study was aimed to evaluate the effectiveness of platelet rich plasma (PRP) in treating patients with minor to moderate knee osteoarthritis (OA) combined with supra-patellar bursitis using a proteomic approach and clinical evaluation tool...
July 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28339434/platelet-rich-plasma-in-musculoskeletal-pathology-a-necessary-rescue-or-a-lost-cause
#16
REVIEW
Annu Navani, Gang Li, Joshua Chrystal
BACKGROUND: Platelet rich plasma (PRP) has been used for decades to facilitate surgical tissue repair; therefore, the current trend of percutaneously injecting PRP to theoretically enhance tissue regeneration and repair is a logical progression. Applications include treatment of osteoarthritis, tendinopathy, chondropathy, acute and chronic soft tissue injuries, muscle or ligament tear, as well as enhancement of healing after bone or tissue reconstruction. However, there is limited evidence to support the use of PRP in the abovementioned conditions...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28018908/partial-cranial-cruciate-ligament-tears-treated-with-stem-cell-and-platelet-rich-plasma-combination-therapy-in-36-dogs-a-retrospective-study
#17
Sherman O Canapp, Christopher S Leasure, Catherine Cox, Victor Ibrahim, Brittany J Carr
OBJECTIVE: To evaluate outcomes in 36 dogs with a partial cranial cruciate ligament (CCL) tear treated with autologous bone marrow aspirate concentrate (BMAC) or adipose-derived progenitor cells (ADPC) with platelet-rich plasma (PRP) combination. MATERIALS AND METHODS: Medical records of client-owned dogs diagnosed with an early partial (≤50%) tear of the craniomedial band of the CCL that was treated with BMAC-PRP or ADPC-PRP were reviewed from 2010 to 2015. Signalment, medical history, physical and orthopedic examination, objective temporospatial gait analyses, radiographs, day 0 and day 90 diagnostic arthroscopy findings, treatment, and outcome were among the data collected...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27998240/superparamagnetic-iron-oxide-nanoparticles-in-musculoskeletal-biology
#18
Shama R Iyer, Su Xu, Joseph P Stains, Craig H Bennett, Richard M Lovering
The use of platelet-rich plasma and mesenchymal stem cells has garnered much attention in orthopedic medicine, focusing on the biological aspects of cell function. However, shortly after systemic delivery, or even a local injection, few of the transplanted stem cells or platelets remain at the target site. Improvement in delivery, and the ability to track and monitor injected cells, would greatly improve clinical translation. Nanoparticles can effectively and quickly label most cells in vitro, and evidence to date suggests such labeling does not compromise the proliferation or differentiation of cells...
August 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27726423/plantar-fasciitis-a-comparison-of-treatment-with-intralesional-steroids-versus-platelet-rich-plasma-a-randomized-blinded-study
#19
Carlos Acosta-Olivo, Jorge Elizondo-Rodriguez, Ricardo Lopez-Cavazos, Felix Vilchez-Cavazos, Mario Simental-Mendia, Oscar Mendoza-Lemus
BACKGROUND: Many treatment options for plantar fasciitis currently exist, some with great success in pain relief. The objective of our study was to compare the use of intralesional steroids with platelet-rich plasma (PRP), using pain scales and functional evaluation, in patients with plantar fasciitis who did not respond to conservative treatment. METHODS: A controlled, randomized, blinded clinical assay was performed. Patients were assigned to one of the two groups by selecting a sealed envelope...
November 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27668218/the-use-of-adipose-derived-progenitor-cells-and-platelet-rich-plasma-combination-for-the-treatment-of-supraspinatus-tendinopathy-in-55-dogs-a-retrospective-study
#20
Sherman O Canapp, Debra A Canapp, Victor Ibrahim, Brittany Jean Carr, Catherine Cox, Jennifer G Barrett
OBJECTIVE: To report clinical findings and outcomes for 55 dogs with supraspinatus tendinopathy (ST) treated with adipose-derived progenitor cells and platelet-rich plasma (ADPC-PRP) therapy. METHODS: Medical records of client-owned dogs diagnosed with ST that were treated with ADPC-PRP combination therapy were reviewed from 2006 to 2013. Data collected included signalment, medical history, limb involvement, prior treatments, physical and orthopedic examination, objective temporospatial gait analysis findings, diagnostic imaging results (radiography, magnetic resonance imaging, musculoskeletal ultrasonography), arthroscopy findings, and outcome...
2016: Frontiers in Veterinary Science
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