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Huge Hepatocellular Carcinoma

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https://www.readbyqxmd.com/read/27817236/-incidence-of-hepatocellular-carcinoma-and-consequent-lessons-for-its-management-in-northeastern-hungary
#1
Renáta Papp, Mária Papp, István Tornai, Zsuzsanna Vitális
INTRODUCTION: The increasing incidence and poor prognosis of hepatocellular carcinoma places huge burden on healthcare. AIM: After reviewing literature on epidemiological trends, risk factors, diagnosis and management options for hepatocellular carcinoma, the authors investigated results of treatment and survival data of patients in Northeastern Hungary. METHOD: In a retrospective study, the authors analyzed medical records of 187 patients with hepatocellular carcinoma (etiology, presence of cirrhosis, stage of the tumor, treatment and disease outcome)...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27752888/splenectomy-suppresses-growth-and-metastasis-of-hepatocellular-carcinoma-through-decreasing-myeloid-derived-suppressor-cells-in-vivo
#2
Xin Long, Jian Wang, Jian-Ping Zhao, Hui-Fang Liang, Peng Zhu, Qi Cheng, Qian Chen, Yan-Hui Wu, Zhan-Guo Zhang, Bi-Xiang Zhang, Xiao-Ping Chen
The function of the spleen in tumor development has been investigated for years. The relationship of the spleen with hepatocellular carcinoma (HCC), a huge health burden worldwide, however, remains unknown. The present study aimed to examine the effect of splenectomy on the development of HCC and the possible mechanism. Mouse hepatic carcinoma lines H22 and Hepa1-6 as well as BALB/c and C57 mice were used to establish orthotopic and metastatic mouse models of liver cancer. Mice were divided into four groups, including control group, splenectomy control group (S group), tumor group (T group) and tumor plus splenectomy group (T+S group)...
October 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27724929/perioperative-and-long-term-outcomes-of-liver-resection-for-hepatitis-b-virus-related-hepatocellular-carcinoma-without-versus-with-hepatic-inflow-occlusion-study-protocol-for-a-prospective-randomized-controlled-trial
#3
Yinzhe Xu, Jiye Chen, Hongguang Wang, Hui Zheng, Dan Feng, Aiqun Zhang, Jianjun Leng, Weidong Duan, Zhanyu Yang, Mingyi Chen, Xianjie Shi, Shouwang Cai, Wenbin Ji, Kai Jiang, Wenzhi Zhang, Yongliang Chen, Wanqing Gu, Jiahong Dong, Shichun Lu
BACKGROUND: The high prevalence of hepatitis B virus (HBV) imposes a huge burden of hepatocellular carcinoma (HCC) in Asia. Surgical resection remains an important therapeutic strategy for HCC. Hepatic inflow occlusion, known as the Pringle maneuver, is the most commonly used method of reducing blood loss during liver parenchymal transection. A major issue with this maneuver is ischemia-reperfusion injury to the remnant liver, and the hemodynamic disturbance it induces in the tumor-bearing liver raises an oncological concern...
October 11, 2016: Trials
https://www.readbyqxmd.com/read/27693406/reveal-the-molecular-signatures-of-hepatocellular-carcinoma-with-different-sizes-by-itraq-based-quantitative-proteomics
#4
Yingchao Wang, Hongzhi Liu, Dong Liang, Yao Huang, Yongyi Zeng, Xiaohua Xing, Jiangbao Xia, Minjie Lin, Xiao Han, Naishun Liao, Xiaolong Liu, Jingfeng Liu
: Tumor size of hepatocellular carcinoma (HCC) is a key parameter for predicting prognosis of HCC patients. The biological behaviors of HCC, such as tumor growth, recurrence and metastasis are significantly associated with tumor size. However, the underlying molecular mechanisms remain unclear. Here, we applied iTRAQ-based proteomic strategy to analyze the proteome differences among small, media, large and huge primary HCC tissues. In brief,88 proteins in small HCC, 69 proteins in media HCC, 118 proteins in large HCC and 215 proteins in huge HCC, were identified by comparing the proteome of cancerous tissues with its corresponding non-cancerous tissues...
September 28, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27686541/-clinical-application-of-multi-electrode-synchronous-radiofrequency-ablation-via-switching-controller-for-treating-large-hepatocellular-carcinoma
#5
T Q Zhang, Y Y Zhang, Y K Gu, F Gao, Z M Huang, J H Huang
Objective: To explore the preliminary clinical efficacy and safety of multi-electrode synchronous radiofrequency ablation via switching controller for treating large hepatocellular carcinoma. Methods: A total of 20 patients with large hepatocellular carcinoma from minimally invasive Interventional department of Sun Yat-sen University Cancer Center were enrolled in this retrospective study from December 2013 to December 2014.The procedures were conducted with multi-electrode synchronous radiofrequency ablation via switching controller under CT guidance...
September 20, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27680220/successful-surgical-resection-of-solitary-plasmacytoma-of-the-liver-mimicking-hepatocellular-carcinoma-a-case-report
#6
Mariateresa Mirarchi, Emilio De Raffele, Francesco Bacci, Dajana Cuicchi, Ferdinando Lecce, Bruno Cola
: Solitary extramedullary plasmacitomas (SEMP) of the liver are very rare. We report the case of an elderly woman with a huge symptomatic SEMP of the liver mimicking hepatocellular carcinoma (HCC). The patient was a 89-year-old woman who presented with severe abdominal pain and a huge solid mass in the right hypochondrium. The laboratory data on admission revealed normal liver function tests. A multiphasic computed tomography (CT) showed a huge solid mass of the left hemiliver, hypoattenuating on noncontrast images, dishomogeneously hyperenhancing in the late arterial phase, with washout in the portal venous and equilibrium phases...
2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27615182/-vaccination-against-hepatitis-b-success-and-challenges
#7
Marie-Louise Michel
Hepatitis B virus is a worldwide leading cause of acute and chronic liver disease including cirrhosis and hepatocellular carcinoma. Effective vaccines have been available since the early '80s. Vaccination against hepatitis B virus infection has proved highly successful in reducing the disease burden, the development of the carrier state and the hepatitis B-related morbidity and mortality in the countries where vaccination has been implemented. Despite success and efficacy of preventive vaccines, a huge number of chronically infected patients still remain...
August 2016: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/27587209/-safety-assessment-of-hepatectomy-for-huge-hepatocellular-carcinoma-by-three-dimensional-reconstruction-technique
#8
L Chen, H P Luo, S L Dong, X P Chen
OBJECTIVE: To explore the effectiveness of three-dimentional(3D)reconstruction technique in safety assessment of hepatectomy for large hepatocellular carcinoma(HCC). METHODS: The clinical records of 28 patients who underwent resection of HCC greater than 10 cm in diameter from January 2013 to December 2015 at Department of Hepatic Surgery, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology were studied retrospectively. All patients underwent enhanced computer tomography (CT), then 3D images of liver and tumor were reconstructed by uploading the CT imaging data to IQQA-Liver system...
September 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27550624/long-term-survival-of-patients-undergoing-liver-resection-for-very-large-hepatocellular-carcinomas
#9
Y J Chang, K P Chung, Y J Chang, L J Chen
BACKGROUND: This study aimed to assess long-term survival after liver resection for huge hepatocellular carcinoma (HCC). METHODS: Patients with stage I-III HCC who underwent hepatectomy from 2002 to 2010 were identified retrospectively from prospective national databases and followed until December 2012. Patients were assigned into four groups according to tumour size: less than 3·0 cm (small), 3·0-4·9 cm (medium), 5·0-10·0 cm (large) and over 10·0 cm (huge)...
October 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27484960/the-alpps-procedure-for-hepatocellular-carcinoma-larger-than-10-centimeters
#10
Orlando Jorge M Torres, Rodrigo Rodrigues Vasques, Thiago Henrique S Silva, Miguel Eugenio L Castelo-Branco, Camila Cristina S Torres
INTRODUCTION: The only means of achieving long-term survival in hepatocellular carcinoma is complete tumor resection or liver transplantation. Patients with large hepatocellular carcinomas are currently not considered for liver transplantation. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is indicated in selected patients. We present the case of a patient with a huge hepatocellular carcinoma who underwent an ALPPS procedure. PRESENTATION OF CASE: A 57-year-old man initially presented with a tumor measuring 19cm×10cm in the right lobe of the liver...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27306318/the-association-of-six-non-synonymous-variants-in-three-dna-repair-genes-with-hepatocellular-carcinoma-risk-a-meta-analysis
#11
Yan-Hui Shi, Bin Wang, Bai-Ping Xu, Dan-Na Jiang, Dong-Mei Zhao, Man-Ru Ji, Li Zhou, Xue Li, Chang-Zhu Lu
Hepatocellular carcinoma is a complex polygenic disease. Despite the huge advances in genetic epidemiology, it still remains a challenge to unveil the genetic architecture of hepatocellular carcinoma. We, therefore, decided to meta-analytically assess the association of six non-synonymous coding variants from XRCC1, XRCC3 and XPD genes with hepatocellular carcinoma risk by pooling the results of 20 English articles. This meta-analysis was conducted according to the PRISMA statement, and data collection was independently completed in duplicate...
June 16, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27293455/treatment-of-huge-hepatocellular-carcinoma-using-cinobufacini-injection-in-transarterial-chemoembolization-a-retrospective-study
#12
Jun Dong, Xiaofeng Zhai, Zhe Chen, Qun Liu, Hua Ye, Wei Chen, Changquan Ling
The aim of this study is to examine the safety and efficacy of Cinobufacini injection in transarterial chemoembolization (TACE) for treatment of huge hepatocellular carcinoma (HCC). Clinical data of 56 consecutive patients with HCC larger than 10 cm who had been treated with TACE between December 2010 and August 2014 were retrospectively analyzed. Among these patients, 31 belonged to the Cinobufacini group and 25 belonged to the epirubicin group. The clinical efficacy, survival time, and adverse events in patients in the two groups were compared...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27264430/a-case-of-resected-hepatocellular-carcinoma-after-drug-eluting-bead-transarterial-chemoembolization
#13
Atsuyuki Ikeda, Yumiko Yasuhara, Daizen Hirata, Mari Teramura, Takeharu Nakamura, Yoko Oiwa, Osamu Araki, Hidemasa Azechi, Ryuta Nishitai, Hiroyuki Kokuryu
We report a case of resected hepatocellular carcinomas (HCCs) after drug-eluting bead transarterial chemoembolization (DEB-TACE). A 67-year-old man with alcoholic liver disease was diagnosed with HCCs. Serological markers for hepatitis B and C viruses were negative. Among tumor markers, alpha-fetoprotein was 2.7ng/mL, and protein induced by vitamin K absence II was 868mAU/mL. Two HCCs were detected using dynamic computed tomography: one was 9cm in diameter in S8 and the other was 2cm in diameter in S4. We performed DEB-TACE using HepaSphere(®) and epirubicin...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27216550/association-between-aerobic-exercise-and-rosiglitazone-avoided-the-nafld-and-liver-inflammation-exacerbated-in-ppar-%C3%AE-knockout-mice
#14
Helena A P Batatinha, Edson A Lima, Alexandre A S Teixeira, Camila O Souza, Luana A Biondo, Loreana S Silveira, Fabio S Lira, José C Rosa Neto
Nonalcoholic fatty liver disease (NAFLD) is one of the main liver diseases today, and may progress to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Some studies have shown the beneficial effects of aerobic exercise on reversing NAFLD. To verify whether chronic aerobic exercise improves the insulin resistance, liver inflammation, and steatohepatitis caused by a high fat diet (HF) and whether PPARα is involved in these actions. C57BL6 wild type (WT) and PPAR-α knockout (KO) mice were fed with a standard diet (SD) or HF during 12 weeks; the HF mice were trained on a treadmill during the last 8 weeks...
May 23, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27186574/associating-microwave-ablation-and-portal-vein-ligation-for-staged-hepatectomy-for-the-treatment-of-huge-hepatocellular-carcinoma-with-cirrhosis
#15
Jian-Xun Chen, Heng-Quan Ran, Chang-Qin Sun
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) could induce extensive and rapid future liver remnant hypertrophy. However, the morbidity for ALPPS is very high. This paper reports a modified ALPPS (associating microwave ablation and portal vein ligation for staged hepatectomy, AMAPS), which was successfully applied in the treatment of huge hepatocellular carcinoma with cirrhosis, and the procedure of operation was greatly simplified. Hence, AMAPS is feasible and safe in selected patients with primary hepatocellular carcinoma and cirrhosis...
May 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27182434/circulating-tumor-dna-in-hepatocellular-carcinoma-trends-and-challenges
#16
REVIEW
Jia-Cheng Tang, Yi-Li Feng, Tao Guo, An-Yong Xie, Xiu-Jun Cai
Molecular characterization of individual patients' tumor cells is becoming increasingly important in offering effective treatment for patients in clinical practice. Recent advances in the field have indicated that circulating tumor DNA (ctDNA) has huge potential to serve as a biomarker for early detection and precision treatment as well as prognosis of hepatocellular carcinoma (HCC). As ctDNA in HCC patients harbors the molecular characteristics of HCC tumor cells, ctDNA analysis in the blood may be sufficient for convenient, non-invasive and accurate detection, providing information for HCC diagnosis, treatment and prognosis...
2016: Cell & Bioscience
https://www.readbyqxmd.com/read/27100425/repeated-radiofrequency-ablation-combined-with-ablated-lesion-elimination-and-transarterial-chemoembolization-improves-the-outcome-of-solitary-huge-hepatocellular-carcinomas-10-m-or-larger
#17
MULTICENTER STUDY
Shan Ke, Jun Gao, Jian Kong, Xue-Mei Ding, Hai-Gang Niu, Zong-Hai Xin, Chun-Min Ning, Shi-Gang Guo, Xiao-Long Li, Long Zhang, Yong-Hong Dong, Wen-Bing Sun
This study investigated the effectiveness of a new strategy, repeated radiofrequency (RF) ablation combined with ablated lesion elimination following transarterial chemoembolization (TACE)/transarterial embolization (TAE), for solitary huge hepatocellular carcinoma (SHHCC) 10 cm or larger. From July 2008 to October 2015, 39 consecutive patients with SHHCC were screened. Of these, 12 were treated with TACE/TAE and repeated RF ablation (TACE/TAE + RF ablation group) and the remaining 27 patients were treated with the aforementioned new strategy (new strategy group)...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27049255/prioritization-of-high-cost-new-drugs-for-hcv-making-sustainability-ethical
#18
L Craxì, D Sacchini, P Refolo, R Minacori, V Daloiso, G Ricci, R Bruno, C Cammà, A Cicchetti, A Gasbarrini, A G Spagnolo
Hepatitis C virus (HCV) infection is a major health problem worldwide. Chronic HCV infection may in the long run cause cirrhosis, hepatic decompensation and hepatocellular carcinoma, with an ultimate disease burden of at least 350,000 deaths per year worldwide. The new generation of highly effective direct acting antivirals (DAA) to treat HCV infection brings major promises to infected patients in terms of exceedingly high rates of sustained virological response (SVR) but also of tolerability, allowing even the sickest patients to be treated...
2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27015844/the-mechanism-of-apoliprotein-a1-down-regulated-by-hepatitis-b-virus
#19
Yuanyuan Wang, Junli Hao, Xiaohong Liu, Hongxin Wang, Xin Zeng, Jing Yang, Lei Li, Xi Kuang, Tao Zhang
BACKGROUND: Hepatitis B virus (HBV) infection correlated with the development of cirrhosis, liver failure and hepatocellular carcinoma (HCC), poses a huge health burden on the global community. However, the pathogenesis of chronic hepatitis B (CHB) remains unclear. Apolipoprotein A1 (ApoA1) mainly secreted by hepatocytes, represents the major protein component of high-density lipoprotein. ApoA1 secretion may be disrupted by HBV infection. In this study, we mainly investigated the molecular mechanism of ApoA1 down regulated by HBV for revealing the pathogenesis of CHB...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/26861568/significance-of-neutrophil-to-lymphocyte-ratio-platelet-to-lymphocyte-ratio-and-prognostic-nutrition-index-as-preoperative-predictors-of-early-mortality-after-liver-resection-for-huge-%C3%A2-10%C3%A2-cm-hepatocellular-carcinoma
#20
Brian K P Goh, Juinn Huar Kam, Ser-Yee Lee, Chung-Yip Chan, John C Allen, Premaraj Jeyaraj, Peng-Chung Cheow, Pierce K H Chow, London L P J Ooi, Alexander Y F Chung
BACKGROUND: This study aimed to determine preoperative predictors of early (<1 year) mortality from disease recurrence after liver resection (LR) for huge (≥10 cm) HCC, with special emphasis on the importance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutrition index (PNI). METHODS: Between 2000 to 2013, 166 patients underwent LR for huge HCC. Optimal cut-offs for alpha fetoprotein (AFP), NLR, PLR, and PNI were determined by plotting the receiver operator curves (ROC) in predicting early mortality and utilizing the Youden index...
May 2016: Journal of Surgical Oncology
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