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HCC Recurrence

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https://www.readbyqxmd.com/read/28239817/does-the-margin-width-influence-recurrence-rate-in-liver-surgery-for-hepatocellular-carcinoma-smaller-than-5-cm
#1
C Lazzara, G Navarra, S Lazzara, A Barbera, C Saitta, G Raimondo, S Latteri, G Currò
OBJECTIVE: Liver surgery is considered a curative treatment for hepatocellular carcinoma (HCC) but the importance of resection margin width remains controversial. The aim of this study is to clarify the role of 5-10 mm surgical margin width on post-operative recurrence and overall survival after resection. PATIENTS AND METHODS: We analyzed recurrence rate and overall survival rate of 72 patients who underwent curative hepatic resection for HCC smaller than 5 cm with 5-10 mm surgical margin width between January 2005 and December 2014...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28223736/percutaneous-electrochemotherapy-in-the-treatment-of-portal-vein-tumor-thrombosis-at-hepatic-hilum-in-patients-with-hepatocellular-carcinoma-in-cirrhosis-a-feasibility-study
#2
Luciano Tarantino, Giuseppina Busto, Aurelio Nasto, Raffaele Fristachi, Luigi Cacace, Maria Talamo, Catello Accardo, Sara Bortone, Paolo Gallo, Paolo Tarantino, Riccardo Aurelio Nasto, Matteo Nicola Dario Di Minno, Pasquale Ambrosino
AIM: To treated with electrochemotherapy (ECT) a prospective case series of patients with liver cirrhosis and Vp3-Vp4- portal vein tumor thrombus (PVTT) from hepatocellular carcinoma (HCC), in order to evaluate the feasibility, safety and efficacy of this new non thermal ablative technique in those patients. METHODS: Six patients (5 males and 1 female), aged 61-85 years (mean age, 70 years), four in Child-Pugh A and two in Child-Pugh B class, entered our study series...
February 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28220382/meta-analysis-of-laparoscopic-vs-open-liver-resection-for-hepatocellular-carcinoma
#3
Georgios C Sotiropoulos, Anastasia Prodromidou, Ioannis D Kostakis, Nikolaos Machairas
Laparoscopic liver resections (LLR) are widely accepted as safe and effective procedures for the management of hepatocellular carcinoma (HCC) in the hands of experienced surgeons. The efficacy and extent of benefits of pure as well as hand-assisted laparoscopic and laparoscopy-assisted liver resection over open liver resection (OLR) have been investigated by numerous studies during the last 10 years. The aim of our meta-analysis is to investigate the effect of LLR in short- and long-term outcomes compared to OLR in patients operated for HCC...
February 20, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28216972/laparoscopic-resection-vs-laparoscopic-radiofrequency-ablation-for-the-treatment-of-small-hepatocellular-carcinomas-a-single-center-analysis
#4
Marco Casaccia, Gregorio Santori, Giuliano Bottino, Pietro Diviacco, Enzo Andorno
AIM: To compare survival and recurrence after laparoscopic liver resection (LLR) and laparoscopic radiofrequency ablation (LRFA) for the treatment of small hepatocellular carcinoma (HCC). METHODS: Between June 1, 2005 and November 30, 2010, 46 patients (62.26 ± 8.55 years old; female/male: 12/34) treated for small HCC were enrolled following strict criteria. Patients with better liver function and larger tumors were referred for LLR (n = 24), while those with poorer liver function and multiple tumors were referred for LRFA (n = 22), and they were then followed for similar durations (44...
January 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28208001/predictive-factors-for-complete-response-and-recurrence-after-transarterial-chemoembolization-in-hepatocellular-carcinoma
#5
Shin Ok Jeong, Eui Bae Kim, Soung Won Jeong, Jae Young Jang, Sae Hwan Lee, Sang Gyune Kim, Sang Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Yong Jae Kim, Dong Erk Goo, Su Yeon Park
Background/Aims: To investigate the predictive factors for complete response (CR) and recurrence after CR in patients with hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE). Methods: Among 691 newly diagnosed HCC patients, 287 were treated with TACE as a first therapy. We analyzed the predictive factors for CR, recurrence after CR, and overall survival (OS). Results: Eighty-one patients (28.2%) achieved CR after TACE, and recurrence after CR was detected in 35 patients (43...
February 17, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28206965/prognostic-role-of-platelet-to-lymphocyte-ratio-in-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#6
Yongzhao Zhao, Guangyan Si, Fengshang Zhu, Jialiang Hui, Shangli Cai, Chenshen Huang, Sijin Cheng, Abdel Hamid Fathy, Yi Xiang, Jing Li
BACKGROUND AND AIMS: Several studies were conducted to explore the prognostic significance of platelet to lymphocyte ratio (PLR) in hepatocellular carcinoma (HCC), however, contradictory results across most reports were documented. To this end, we present a systematic review that aims to summarize the prognostic significance of PLR in patients with HCC. RESULTS: A total of 10 studies involving a total of 2,315 patients were identified. The Newcastle-Ottawa Quality Assessment Scale (NOS) of each included study was greater than or equal to 5...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28205284/prognostic-impact-of-complications-after-resection-of-early-stage-hepatocellular-carcinoma
#7
Georgios Antonios Margonis, Kazunari Sasaki, Nikolaos Andreatos, Yujiro Nishioka, Toshitaka Sugawara, Neda Amini, Stefan Buettner, Masaji Hashimoto, Junichi Shindoh, Timothy M Pawlik
BACKGROUND: Resection is the most effective treatment for HCC. However, postoperative morbidity is common and its impact on long-term oncological outcome remains unclear. METHODS: Long-term outcomes of 774 patients who underwent curative resection for early stage HCC at Johns Hopkins Hospital and Toranomon Hospital were investigated after stratifying by the development of postoperative overall and infectious complications. RESULTS: A minor or major postoperative complication developed in 281 and 65 patients, respectively, while postoperative mortality was 1...
February 15, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28205184/extrahepatic-bile-duct-hepatocellular-carcinoma-due-to-recurrence-of-hematogenous-metastasis-50%C3%A2-months-after-hepatectomy
#8
Hiroyuki Kumata, Shigehito Miyagi, Keigo Murakami, Atsushi Fujio, Yasuyuki Hara, Chikashi Nakanishi, Naoki Kawagishi, Hironobu Sasano, Takashi Kamei, Noriaki Ouchi
BACKGROUND: Recurrent hepatocellular carcinoma (HCC) in the extrahepatic bile duct is rare with most cases diagnosed after manifesting sudden obstructive jaundice. Here, we report an extremely rare case of recurrent HCC in the common bile duct due to hematogenous metastasis. CASE PRESENTATION: A 66-year-old man underwent an extended left hepatectomy for HCC in the medial segment of the liver. Fifty months later, he presented with sudden obstructive jaundice. Endoscopic retrograde cholangiography showed a space-occupying lesion in the common bile duct, which was suspected as cholangiocarcinoma...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28202430/vespro-an-individual-patient-data-prospective-meta-analysis-of-selective-internal-radiation-therapy-versus-sorafenib-for-advanced-locally-advanced-or-recurrent-hepatocellular-carcinoma-of-the-sarah-and-sirvenib-trials
#9
Val Gebski, Emma Gibbs, Mihir Gandhi, Gilles Chatellier, Aurelia Dinut, Helena Pereira, Pierce Kh Chow, Valérie Vilgrain
BACKGROUND: Untreated advanced hepatocellular carcinoma (HCC) has an overall poor prognosis. Currently there are 2 ongoing prospective randomized controlled trials that are evaluating the efficacy and safety of sorafenib and selective internal radiation therapy (SIRT) with yttrium-90 resin microspheres in patients with advanced HCC. The SorAfenib versus Radioembolisation in Advanced Hepatocellular carcinoma (SARAH; 459 patients) trial is being performed in Europe and the SIRt VErsus SorafeNIB (SIRveNIB; 360 patients) trial in the Asia Pacific region...
February 15, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28199760/prediction-of-hepatocellular-carcinoma-recurrence-after-liver-transplantation-comparison-of-4-explant-based-prognostic-models
#10
Charlotte E Costentin, Giuliana Amaddeo, Thomas Decaens, Karim Boudjema, Philippe Bachellier, Fabrice Muscari, Ephrem Salame, Pierre Henri Bernard, Claire Francoz, Sébastien Dharancy, Claire Vanlemmens, Sylvie Radenne, Jérôme Dumortier, Marie Noelle Hilleret, Olivier Chazouilleres, Georges Philippe Pageaux, Julien Calderaro, Alexis Laurent, Françoise Roudot-Thoraval, Christophe Duvoux
AIM: Discordance between pre-LT imaging and explanted liver findings have been reported after liver transplantation (LT) for hepatocellular carcinoma (HCC), suggesting the need of re-assessing the risk of HCC recurrence post LT. Our aims were to compare pre-LT imaging and explants features and to test the performances of four explant-based predictive models of recurrence in an external cohort. METHODS: Staging according to preLT imaging and explant features were compared...
February 15, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28197709/glasgow-prognostic-score-and-prognosis-after-hepatectomy-for-hepatocellular-carcinoma
#11
Tomoyuki Abe, Hirotaka Tashiro, Tsuyoshi Kobayashi, Minoru Hattori, Shintaro Kuroda, Hideki Ohdan
BACKGROUND: Systemic inflammation can promote tumor growth. The Glasgow Prognostic Score (GPS), a simple assessment of systemic inflammation status, could be useful to predict the prognosis of hepatocellular carcinoma (HCC) patients after hepatectomy. METHODS: Consecutive HCC patients were enrolled following hepatectomy at our institution between 2005 and 2012. Univariate and multivariate analyses were performed to identify variables associated with overall survival (OS) and recurrence-free survival...
February 14, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28196353/importance-of-screening-for-esophagogastric-varices-in-na%C3%A3-ve-hepatocellular-carcinoma-patients-within-milan-criteria-indicator-for-liver-transplantation
#12
Takamasa Kawakami, Atsushi Hiraoka, Kojiro Michitaka, Tomoyuki Ninomiya, Masashi Hirooka, Yoichi Hiasa
BACKGROUND/AIMS: Patients with hepatocellular carcinoma (HCC) beyond Milan criteria (MC) are not eligible for liver transplantation (LT). To elucidate prognostic factors significantly linked to recurrence beyond MC or death related to the liver, we evaluated the clinical features in a series of HCC patients within MC at baseline. METHODS: We enrolled 255 naïve HCC patients (≤70 years) within the MC who underwent upper-gastrointestinal-endoscopy, and were treated with resection or radiofrequency ablation (62 years old [median]; male:female = 202:53; Child-Pugh A:B = 216:39)...
February 15, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28194035/recurrently-deregulated-lncrnas-in-hepatocellular-carcinoma
#13
Yang Yang, Lei Chen, Jin Gu, Hanshuo Zhang, Jiapei Yuan, Qiuyu Lian, Guishuai Lv, Siqi Wang, Yang Wu, Yu-Cheng T Yang, Dongfang Wang, Yang Liu, Jing Tang, Guijuan Luo, Yang Li, Long Hu, Xinbao Sun, Dong Wang, Mingzhou Guo, Qiaoran Xi, Jianzhong Xi, Hongyang Wang, Michael Q Zhang, Zhi John Lu
Hepatocellular carcinoma (HCC) cells often invade the portal venous system and subsequently develop into portal vein tumour thrombosis (PVTT). Long noncoding RNAs (lncRNAs) have been associated with HCC, but a comprehensive analysis of their specific association with HCC metastasis has not been conducted. Here, by analysing 60 clinical samples' RNA-seq data from 20 HCC patients, we have identified and characterized 8,603 candidate lncRNAs. The expression patterns of 917 recurrently deregulated lncRNAs are correlated with clinical data in a TCGA cohort and published liver cancer data...
February 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28192617/huge-hepatocellular-carcinoma-greater-than-10%C3%A2-cm-in-diameter-worsens-prognosis-by-causing-distant-recurrence-after-curative-resection
#14
Kenji Wakayama, Toshiya Kamiyama, Hideki Yokoo, Tatsuya Orimo, Shingo Shimada, Takahiro Einama, Hirofumi Kamachi, Akinobu Taketomi
BACKGROUND AND OBJECTIVES: This study aimed to evaluate the impact of huge (≥10 cm) hepatocellular carcinoma (HCC) to the recurrence pattern and the prognosis after hepatectomy. METHODS: 574 patients who underwent hepatectomy by 17 surgeons (Open 536 and Laparoscopic 38) for HCC without major vascular invasion from 1990 to 2013 at single institute were retrospectively analyzed. RESULTS: Huge tumor, age, HCV, multiple tumors and microscopic portal invasion are independent risk factors for overall survival (OS), and huge tumor, ICGR15 ≥16%, multiple tumors, moderate/poor histology, microscopic portal invasion and a positive pathological margin are risk factors for relapse-free survival (RFS)...
February 13, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28192185/hepatic-decompensation-is-the-major-driver-of-death-in-hcv-infected-cirrhotic-patients-with-successfully-treated-early-hepatocellular-carcinoma
#15
Giuseppe Cabibbo, Salvatore Petta, Marco Barbara, Simona Attardo, Laura Bucci, Fabio Farinati, Edoardo G Giannini, Giulia Negrini, Francesca Ciccarese, Gian Lodovico Rapaccini, Maria Di Marco, Eugenio Caturelli, Marco Zoli, Franco Borzio, Rodolfo Sacco, Roberto Virdone, Fabio Andrea Marra Mega, Filomena Morisco, Luisa Benvegnù, Antonio Gasbarrini, Gianluca Svegliati-Baroni, Francesco Giuseppe Foschi, Andrea Olivani, Alberto Masotto, Gerardo Nardone, Antonio Colecchia, Marcello Persico, Antonio Craxì, Franco Trevisani, Calogero Cammà
BACKGROUND & AIMS: A major problem in assessing the long-term outcome of HCV-infected cirrhotic patients with successfully treated Barcelona Clinic Liver Cancer (BCLC) A hepatocellular carcinoma (HCC) arises from the lack of models accounting for early changes during follow-up. AIM: of study is to estimate the impact on 5-year overall survival (OS) of early (occurring within 12 months after complete radiological response) time-dependents events (HCC recurrence or hepatic decompensation) in a large cohort of successfully treated HCC patients with HCV cirrhosis...
February 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28189067/microrna-489-plays-an-anti-metastatic-role-in-human-hepatocellular-carcinoma-by-targeting-matrix-metalloproteinase-7
#16
Yixiong Lin, Jianjun Liu, Yuqi Huang, Dingli Liu, Guowei Zhang, Heping Kan
Dysregulation of microRNAs (miRNAs) is actively involved in the pathogenesis and tumorigenicity of hepatocellular carcinoma (HCC). miR-489 was found to play either oncogenic or tumor suppressive roles in human cancers. Recent study reported that the levels of miR-489 in late recurrent HCC patients were evidently higher than that in early recurrent cases, suggesting that miR-489 may function as a tumor suppressive miRNA in HCC. Yet, the clinical value and biological function of miR-489 remain rarely known in HCC...
February 8, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28188668/hiv-infected-liver-transplant-recipients-with-incidental-hepatocellular-carcinoma-a-prospective-multicenter-nationwide-cohort-study
#17
Fernando Agüero, Alejandro Forner, Andrés Valdivieso, Marino Blanes, Rafael Barcena, Christian Manzardo, Antoni Rafecas, Lluis Castells, Manuel Abradelo, Pilar Barrera-Baena, Luisa González-Diéguez, Magdalena Salcedo, Trinidad Serrano, Miguel Jiménez-Pérez, José Ignacio Herrero, Mikel Gastaca, Victoria Aguilera, Juan Fabregat, Santos Del Campo, Itxarone Bilbao, Carlos Jiménez Romero, Asunción Moreno, Antoni Rimola, José M Miro
: There is a lack of data on incidental hepatocellular carcinoma (iHCC) in the setting of liver transplantation (LT) in HIV infected patients. This study aims to describe the frequency, histopathological characteristics and outcomes of HIV-infected LT recipients with iHCC from a Spanish, multicenter cohort in comparison with a matched cohort of LT patients without HIV infection. Fifteen (6%) out of 271 patients with HIV infection who received LT in Spain from 2002-2012 and 38 (5%) out of the 811 HIV-uninfected counterparts presented iHCC in liver explants (p=0...
February 11, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28188425/microwave-ablation-for-the-treatment-of-hepatocellular-carcinoma-that-met-up-to-seven-criteria-feasibility-local-efficacy-and-long-term-outcomes
#18
Yun Xu, Qiang Shen, Pei Liu, Zhongqi Xu, Panpan Wu, Zhenghua Lu, Yi Chen, Bin Huang, Guojun Qian
OBJECTIVES: This study aimed to evaluate the feasibility, local efficacy and long-term outcomes of microwave (MW) ablation for the treatment of hepatocellular carcinoma (HCC) that met up-to-seven criteria. METHODS: Between January 2007 and January 2012, 142 HCC patients with 294 nodules, which conformed to up-to-seven criteria, were enrolled into this retrospective study. All patients were followed up for more than 3 years after receiving MW ablation. Technical success, complications, local tumour progression (LTP) and distant recurrence (DR) were monitored...
February 10, 2017: European Radiology
https://www.readbyqxmd.com/read/28187493/recurrence-of-hepatocellular-carcinoma-after-liver-transplantation-is-there-a-place-for-resection
#19
Elena Fernandez-Sevilla, Marc-Antoine Allard, Jasmijn Selten, Nicolas Golse, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Castaing Denis, René Adam
INTRODUCTION: Recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is widely considered as a terminal condition. Therefore, the role of surgery is uncertain in this case. The purpose of this study was to identify the prognostic factors of survival after post-LT HCC recurrence and evaluate the impact of surgery in this setting. PATIENTS AND METHODS: All patients transplanted for HCC between 1991 and 2013 in a single institution and who further developed a post-LT recurrence were included in this study...
February 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28187458/lgr5-promotes-hepatocellular-carcinoma-metastasis-through-inducting-epithelial-mesenchymal-transition
#20
Jie Liu, Guo-Zheng Yu, Xiao-Ke Cheng, Xiao-Dong Li, Xian-Tao Zeng, Xue-Qun Ren
The purpose of the present study was to investigate the prognostic value of Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) in hepatocellular carcinoma (HCC) and its role in promoting HCC metastasis. The expression level of LGR5 in liver tumor tissues and adjacent non-tumor tissues were detected adopting immunohistochemistry (IHC), real-time PCR (RT-PCR) and western blot assays. Chi-square test was used to evaluate the correlation between LGR5 expression and clinicopathological characteristics...
February 7, 2017: Oncotarget
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