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https://www.readbyqxmd.com/read/29028787/relationship-between-pd-l1-expression-and-cd8-t-cell-immune-responses-in-hepatocellular-carcinoma
#1
Chun-Yu Huang, Ying Wang, Guang-Yu Luo, Feng Han, Yong-Qiang Li, Zhong-Guo Zhou, Guo-Liang Xu
As PD-1/PD-L1 immune checkpoint inhibitors exhibited promising clinical outcomes in various types of solid tumors, PD-1/PD-L1 blockades have been explored for the treatment of hepatocellular carcinoma (HCC). However, the association of PD-L1 with antitumor immunoregulation is not clearly defined in HCC. Here, we evaluated the characteristics of PD-L1 expression, CD8 T-cell infiltration and their relationship in HCC. A total of 411 resected tumor specimens from HCC patients were immunostained for PD-L1 and CD8...
November 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29027712/upregulation-of-ube2q1-via-gene-copy-number-gain-in-hepatocellular-carcinoma-promotes-cancer-progression-through-%C3%AE-catenin-egfr-pi3k-akt-mtor-signaling-pathway
#2
Bin Zhang, Chao Deng, Lei Wang, Fan Zhou, Shu Zhang, Wei Kang, Ping Zhan, Juan Chen, Shanshan Shen, Huimin Guo, Ming Zhang, Yi Wang, Feng Zhang, Wei Zhang, Jiangqiang Xiao, Bo Kong, Helmut Friess, Yuzheng Zhuge, Hongli Yan, Xiaoping Zou
Hepatocellular carcinoma (HCC) is the most common type of liver cancer and represents a highly malignant tumor with a poor prognosis. Therapeutic modalities for HCC are limited and generally ineffective. UBE2Q1 is a putative E2 ubiquitin conjugating enzyme, and has been shown to be overexpressed in various types of cancers including HCC. How UBE2Q1 contributes to hepatocarcinogenesis remains unknown. Here, we show that UBE2Q1 is up-regulated in HCC cell lines and in a subset of human HCC tissues. Up-regulation of UBE2Q1 in primary HCC tumors was significantly correlated with shorter overall survival and disease-free survival...
October 13, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29026966/the-clinical-implications-of-liver-resection-margin-size-in-patients-with-hepatocellular-carcinoma-in-terms-of-positron-emission-tomography-positivity
#3
Jae Hyun Park, Dong Hwi Kim, Sung Hoon Kim, Moon Young Kim, Soon Koo Baik, In Su Hong
BACKGROUND: The positivity of positron emission tomography (PET) in hepatocellular carcinoma (HCC) correlates with aggressive tumor factors and poor survival. Adequate resection margin size is still a topic of debate. We analyzed the clinical implications of resection margin size in patients with HCC in terms of PET positivity. METHODS: We retrospectively reviewed the medical records of 92 patients who underwent liver resection from March 2012 to October 2015. We investigated prognostic factors for recurrence and survival...
October 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29025594/gene-expression-profiling-pathway-analysis-and-subtype-classification-reveal-molecular-heterogeneity-in-hepatocellular-carcinoma-and-suggest-subtype-specific-therapeutic-targets
#4
Rahul Agarwal, Jitendra Narayan, Amitava Bhattacharyya, Mayank Saraswat, Anil Kumar Tomar
A very low 5-year survival rate among hepatocellular carcinoma (HCC) patients is mainly due to lack of early stage diagnosis, distant metastasis and high risk of postoperative recurrence. Hence ascertaining novel biomarkers for early diagnosis and patient specific therapeutics is crucial and urgent. Here, we have performed a comprehensive analysis of the expression data of 423 HCC patients (373 tumors and 50 controls) downloaded from The Cancer Genome Atlas (TCGA) followed by pathway enrichment by gene ontology annotations, subtype classification and overall survival analysis...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29024412/risk-of-post-transplant-hepatocellular-carcinoma-recurrence-is-greater-in-recipients-with-higher-platelet-counts-in-living-donor-liver-transplantation
#5
Sangbin Han, Sanghoon Lee, Ju Dong Yang, Michael Douglas Leise, Joong Hyun Ahn, Seonwoo Kim, Gangha Jung, Mi Sook Gwak, Gaab Soo Kim, Justin Sangwook Ko
Platelets interact with tumor cells and promote metastasis. The importance of platelets in post-transplant hepatocellular carcinoma (HCC) recurrence is unclear. Thus, we aimed to evaluate the association between preoperative platelet count and HCC recurrence after living donor liver transplantation. Of 359 recipients of livers from living donors for HCC, 209 of 240 patients who had preoperative platelet count ≤75 × 10(9) /L were matched with 97 of 119 patients who had preoperative platelet count >75 × 10(9) /L using propensity score matching, with an unfixed matching ratio based on factors such as tumor biology...
October 11, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29024228/de-novo-hepatocellular-carcinoma-post-multivisceral-transplantation-in-a-child
#6
P Tran, S Zhou, L Wang, M Finegold, L Mascarenas, S Alexopolous, Y Genyk, N Kerkar
De novo hepatocellular carcinoma (HCC) post-transplantation in patients without viral hepatitis is extremely rare, with only three reported adult cases in the English literature. Here, we present a case of de novo HCC that developed in a 7-year-old female, who at 8 months of age received a liver, small bowel, spleen, and pancreas transplantation 6.5 years ago for gastroschisis and total parenteral nutrition (TPN)-related cirrhosis. The post-transplant course was complicated by Epstein-Barr virus (EBV) infection, post-transplant lymphoproliferative disease, and subsequent development of multifocal EBV-associated post-transplant smooth muscle tumors (EBV-PTSMT) in the small bowel 1 year and 10 months after transplantation, respectively...
November 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29023899/visceral-adiposity-increases-risk-for-hepatocellular-carcinoma-in-male-patients-with-cirrhosis-and-recurrence-after-liver-transplant
#7
Aldo J Montano-Loza, Vera C Mazurak, Maryam Ebadi, Judith Meza-Junco, Michael B Sawyer, Vickie E Baracos, Norman Kneteman
Visceral adipose tissue (VAT) is a metabolically active organ, associated with higher risk of malignancies. We aimed to evaluate if VAT is associated with the risk of hepatocellular carcinoma (HCC) in patients presenting with cirrhosis as well as HCC recurrence after liver transplantation (LT). Cirrhotic patients (n=678; 457 males) who were assessed for LT (289 with HCC) were evaluated for body composition analysis. Patients who underwent LT (n=247, 168 males) were subsequently evaluated for body composition, and 96 of these patients (78 males) had HCC...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28993607/liver-transplantation-for-high-risk-hepatocellular-carcinoma-after-liver-resection-a-sequential-or-salvage-approach
#8
Chih-Che Lin, Ahmed M Elsarawy, Wei-Feng Li, Ting-Lung Lin, Chee-Chien Yong, Shih-Ho Wang, Chih-Chi Wang, Fang-Ying Kuo, Yu-Fan Cheng, Chao-Long Chen
BACKGROUND Liver transplantation (LT) is the best radical treatment of hepatocellular carcinoma (HCC). Salvage liver transplantation (SalvLT) provides good outcomes for recurrent HCC cases after initial curative liver resection (LR). However, the salvage strategy is not feasible in all situations due to aggressive recurrences. Recently, sequential liver transplantation (SeqLT) was proposed for cases that show adverse pathological features after LR, thus LT is performed pre-emptively before recurrence. In this report, we compared the outcomes of SalvLT and SeqLT for surgical treatment of HCC...
October 10, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28989095/risk-factors-and-prevention-of-hepatocellular-carcinoma-in-the-era-of-precision-medicine
#9
REVIEW
Naoto Fujiwara, Scott L Friedman, Nicolas Goossens, Yujin Hoshida
Chronic fibrotic liver disease caused by viral or metabolic etiologies is a high-risk condition for developing hepatocellular carcinoma (HCC). Even after complete HCC tumor resection or ablation, the carcinogenic tissue microenvironment in the remnant liver can give rise to recurrent de novo HCC tumors, which progress into incurable, advanced-stage disease in the majority of patients. Thus, early detection and prevention of HCC development is, in principle, the most impactful strategy to improve patient prognosis...
October 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28989094/impact-of-time-to-surgery-in-the-outcome-of-patients-with-liver-resection-for-bclc-0-a-stage-hepatocellular-carcinoma
#10
Chetana Lim, Prashant Bhangui, Chady Salloum, Concepción Gómez Gavara, Eylon Lahat, Alain Luciani, Philippe Compagnon, Julien Calderaro, Cyrille Feray, Daniel Azoulay
BACKGROUND & AIMS: The Barcelona Clinic Liver Cancer (BCLC) guidelines recommend resection for very early and early single hepatocellular carcinoma (HCC) patients. It is not known whether a delay in resection from the time of diagnosis (the time-to-surgery (TTS), i.e., the elapsed time from diagnosis to surgery) affects outcomes. We aim to evaluate the impact of TTS on the recurrence and survival outcomes. METHODS: All patients resected for BCLC stage 0-A single HCC from 2006 to 2016 were studied to evaluate the impact of TTS on recurrence rate, recurrence-free survival (RFS), transplantability following recurrence, and intention-to-treat overall survival (ITT-OS)...
October 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28989060/metroticket-2-0-model-for-analysis-of-competing-risks-of-death-following-liver-transplantation-for-hepatocellular-carcinoma
#11
Vincenzo Mazzaferro, Carlo Sposito, Jian Zhou, Antonio D Pinna, Luciano De Carlis, Jia Fan, Matteo Cescon, Stefano Di Sandro, He Yi-Feng, Andrea Lauterio, Marco Bongini, Alessandro Cucchetti
BACKGROUND & AIMS: Outcomes of liver transplantation for hepatocellular carcinoma (HCC) are determined by cancer-related and non-related events. Treatments for hepatitis C virus (HCV) infection have reduced non-cancer events among patients receiving liver transplants, so reducing HCC-related death might be an actionable endpoint. We performed a competing risk analysis to evaluate factors associated with survival of patients with HCC, and developed a prognostic model based on features of HCC patients before liver transplantation...
October 5, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28987561/therapeutic-significance-and-indications-of-pulmonary-metastasectomy-for-hepatocellular-carcinoma-following-liver-resection
#12
Zhigang Hu, Wenbin Li, Pinbo Huang, Zhenyu Zhou, Junyao Xu, Kang Xu, Jie Wang, Heyun Zhang
BACKGROUND: To explore the therapeutic significance and indications of pulmonary metastasectomy (PMT) in hepatocellular carcinoma (HCC) patients with pulmonary metastasis (PM) following liver resection (LR). PATIENTS AND METHODS: PM-HCC patients who underwent LR were retrospectively enrolled, and survival outcomes and prognostic factors were analyzed. Patients were divided into PMT and non-PMT group, and propensity score matching (PSM) analysis was used for survival comparison...
October 5, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28984009/microrna-125b-expression-and-intrahepatic-metastasis-are-predictors-for-early-recurrence-after-hepatocellular-carcinoma-resection
#13
Tomonari Shimagaki, Tomoharu Yoshizumi, Norifumi Harimoto, Sachiyo Yoshio, Yutaka Naito, Yusuke Yamamoto, Takahiro Ochiya, Yoshihiro Yoshida, Tatsuya Kanto, Yoshihiko Maehara
AIM: Early hepatocellular carcinoma (HCC) recurrence after curative resection is a known poor prognostic factor. We aimed to identify microRNAs associated with recurrence after curative HCC resection. METHODS: To identify risk factors for early recurrence and metastasis, 694 patients who underwent primary curative HCC resection were analyzed. We evaluated microRNA expression in cancerous and noncancerous tissues by microarray and qPCR analyses using 16 HCC samples...
October 6, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28983724/liver-function-assessment-using-albumin-bilirubin-grade-for-patients-with-very-early-stage-hepatocellular-carcinoma-treated-with-radiofrequency-ablation
#14
In Soo Oh, Dong Hyun Sinn, Tae Wook Kang, Min Woo Lee, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik
BACKGROUND/AIM: Assessment of liver function is essential for management of hepatocellular carcinoma (HCC). Recently, albumin-bilirubin (ALBI) grade has been reported as a useful tool for assessing hepatic reserve in patients with HCC. The objective of this study was to determine whether ALBI grade could be used to predict the overall survival of very early-stage HCC patients treated with radiofrequency ablation (RF ablation). METHODS: A cohort of 368 patients with very early-stage HCC treated with RF ablation was retrospectively analyzed...
October 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28982915/mir-223-and-stathmin-1-expression-in-non-tumor-liver-tissue-of-patients-with-hepatocellular-carcinoma
#15
Satoru Imura, Shinichiro Yamada, Y U Saito, Shuichi Iwahashi, Yusuke Arakawa, Tetsuya Ikemoto, Yuji Morine, Tohru Utsunomiya, Mitsuo Shimada
AIM: Overexpression of stathmin (STMN1) has been reported for several tumor entities. STMN1 expression correlated with the detection of mutant p53, also suggesting loss-of-function-dependent mechanisms for its accumulation in hepatocellular carcinoma (HCC) cells. On the other hand, miR-223 has been identified as one of the most down-regulated miRNAs in HCC, and its expression was shown to be negatively correlated with STMN1 expression. The aim of this study was to investigate the clinical significance of STMN1 and miRNA-223 expression...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28978885/avoidance-of-platelet-transfusion-with-readministration-of-lusutrombopag-before-radiofrequency-ablation-in-hepatocellular-carcinoma-a-case-report
#16
Satoshi Kotani, Naruaki Kohge, Kousuke Tsukano, Sayaka Ogawa, Satoshi Yamanouchi, Ryusaku Kusunoki, Masahito Aimi, Youichi Miyaoka, Hirofumi Fujishiro
Platelet transfusions are generally administered to patients with liver cirrhosis and associated thrombocytopenia before radiofrequency ablation (RFA). Here, we describe a 77-year-old woman who was diagnosed with hepatitis C, liver cirrhosis, and hepatocellular carcinoma (HCC) in 2006. She underwent RFA in October 2014 and October 2015, with platelet transfusions. She was admitted to our hospital in July 2016 to receive RFA for recurrence of HCC. To avoid platelet transfusion before RFA, she was administered lusutrombopag...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28977857/prognostic-value-and-preoperative-predictors-of-microvascular-invasion-in-solitary-hepatocellular-carcinoma-%C3%A2-5-cm-without-macrovascular-invasion
#17
Hui Zhao, Ye Hua, Zhihua Lu, Shen Gu, Laifa Zhu, Yuan Ji, Yudong Qiu, Tu Dai, Huihan Jin
OBJECTIVES: The aim of this study was to investigate the prognostic value and preoperative predictors of microvascular invasion (MVI) in solitary hepatocellular carcinoma (HCC) ≤ 5 cm without macrovascular invasion. METHODS: A total of 233 consecutive HCC patients underwent curative hepatectomy were included in our study. Independent risk factors influencing the prognosis were identified, and preoperative predictors for MVI were determined. RESULTS: Multivariate regression analysis identified ICG-R15, BCLC staging and MVI as independent risk factors for the overall survival rate...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28974113/combined-radiofrequency-ablation-and-ethanol-injection-versus-repeat-hepatectomy-for-elderly-patients-with-recurrent-hepatocellular-carcinoma-after-initial-hepatic-surgery
#18
Shuling Chen, Zhenwei Peng, Han Xiao, Manxia Lin, Zebin Chen, Chunlin Jiang, Wenjie Hu, Xiaoyan Xie, Longzhong Liu, Baogang Peng, Ming Kuang
PURPOSE: To retrospectively compare the efficacy and safety of combined radiofrequency ablation and percutaneous ethanol injection (RFA-PEI) with repeat hepatectomy for elderly patients with initial recurrent hepatocellular carcinoma (HCC) after hepatic surgery. METHODS: From January 2009 to June 2015, 105 elderly patients (≥ 70 years) who underwent RFA-PEI (n = 57) or repeated hepatectomy (n = 48) for recurrent HCC ≤ 5.0 cm were included in the study...
October 4, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28972877/long-noncoding-rna-in-liver-cancer-stem-cells
#19
Zhaobin Cai, Keyang Xu, Yan Li, Yuanlin Lv, Jianfeng Bao, Liang Qiao
Hepatocellular carcinoma (HCC) is one of the most common malignancies and a major cause of cancer-related deaths. HCC often has an insidious onset, fast progression, and high tendency of metastasis and recurrence, hence it is a highly fatal malignant tumor. The origin of HCC is still a topic of debate but studies over the past decade have clearly identified liver cancer stem cells (LCSCs) being a cardinal source of liver cancer. LCSCs are a small subset of cells with the unlimited ability of self-renewal, differentiation, and uncontrollable growth...
September 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28966983/late-recurrence-of-hepatocellular-carcinoma-after-liver-transplantation
#20
Julia A Zhang, Sandi A Kwee, Linda L Wong
AIMS: Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and liver transplant (LT) prolongs survival. However, 15-20% will experience recurrent HCC, most occurring within 2 years of LT. HCC patients with late recurrences (>5 years after LT) may have distinctive clinical/biological characteristics. METHODS: A retrospective review was conducted of 88 patients who underwent LT for HCC between 1993-2015, analyzing demographics, clinical factors, explant pathology, and outcome...
2017: Hepatoma Research
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