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Eosinophilic myocarditis

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https://www.readbyqxmd.com/read/28762928/-eosinophilic-necrotizing-myocarditis-complicated-by-myocardial-rupture
#1
O Yu Karpova, R Yu Monovtsov, L I Dvoretsky, G R Cherepantsev, A V Magnitskiy
In this female patient eosinophilic myocarditis was complicated by myocardial rupture and hemopericardium with cardiac tamponade. Special features of this case were old age of the patient, fulminant course of the disease, myocardial infarction-like ECG changes, absence of peripheral blood eosinophilia. Presentation is accompanied by discussion of issues of epidemiology, clinical course, diagnostics, and possible causes of eosinophilic myocarditis.
May 2017: Kardiologiia
https://www.readbyqxmd.com/read/28761405/eosinophilia-and-ulcerative-colitis-associated-with-eosinophilic-myocarditis
#2
Katie Murphy, Oral Waldo, Graham M Lohrmann, Henry D Tazelaar, Clinton E Jokerst, Farouk Mookadam
Reactive eosinophilia is associated with inflammatory bowel disease, but its association with eosinophilic myocarditis is rare. We report a case of a 42-year-old man who presented with hypovolemic shock secondary to diarrhea and recently diagnosed nonischemic cardiomyopathy (left ventricular ejection fraction, 0.29). Laboratory evaluation revealed marked peripheral eosinophilia. Cardiac magnetic resonance imaging showed evidence of subacute-to-chronic myocarditis, and endomyocardial biopsy results were consistent with eosinophilic myocarditis...
June 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/28743303/multiorgan-eosinophilic-infiltration-after-initiation-of-clozapine-therapy-a-case-report
#3
Dorota Marchel, Anita L Hart, Patricia Keefer, Jennifer Vredeveld
BACKGROUND: The eosinophilic response to clozapine is well described in the literature, causing a variety of responses, from serositis to colitis. However, there are not case reports describing a clozapine-induced marked eosinophilia resulting in multiorgan dysfunction. CASE PRESENTATION: In this case report, we describe a 24 year old Caucasian male who presented with severe systemic eosinophilia resulting in eosinophilic GI tract infiltration, myocarditis, pericardial and pleural effusions with dramatic improvement following drug withdrawal...
July 25, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28667560/cardiac-autoimmunity-myocarditis
#4
William Bracamonte-Baran, Daniela Čiháková
Myocarditis is the inflammation of the muscle tissues of the heart (myocardium). After a pathologic cardiac-specific inflammatory process, it may progress to chronic damage and dilated cardiomyopathy. The latter is characterized by systolic dysfunction, whose clinical correlate is heart failure. Nevertheless, other acute complications may arise as consequence of tissue damage and electrophysiologic disturbances. Different etiologies are involved in triggering myocarditis. In some cases, such as giant cell myocarditis or eosinophilic necrotizing myocarditis, it is an autoimmune process...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28652675/eosinophilic-myocarditis-and-hypereosinophilic-syndrome
#5
Hanane Boussir, Amine Ghalem, Nabila Ismaili, Noha El Ouafi
Hypereosinophilic syndrome (HES) is a heterogeneous group of hematological disorders characterized by a chronic, unexplained hypereosinophilia with tissue damage. Cardiac involvement occurs in ∼20% of patients with HES and represents a major turning point. Cardiac injuries related to eosinophilia are divided into three chronological phases: eosinophilic infiltration, thrombosis, and fibrosis. We report a case of a 33-year-old woman diagnosed with HES, with pulmonary and gastrointestinal involvement and eosinophilic myocarditis in cardiogenic shock...
July 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28595207/eosinophilic-myocarditis-presenting-as-acute-coronary-syndrome
#6
Evrim Şimşek, Filiz Özerkan Çakan, Mustafa Akın
Eosinophilic myocarditis (EM) is a rare condition that may result from several heterogeneous eosinophilic diseases, including parasite infection, hypersensitivity reaction, vasculitis, and hypereosinophilic syndrome. Regardless of etiology, the disease may present with various cardiac conditions, such as acute coronary syndrome, heart failure, or arrhythmia. Irreversible endomyocardial fibrosis, which causes restrictive cardiomyopathy, occurs in the late phase of the disease. Early diagnosis and treatment is crucial to prevent disease progression...
June 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28576783/survival-and-left-ventricular-function-changes-in-fulminant-versus-nonfulminant-acute-myocarditis
#7
Enrico Ammirati, Manlio Cipriani, Marzia Lilliu, Paola Sormani, Marisa Varrenti, Claudia Raineri, Duccio Petrella, Andrea Garascia, Patrizia Pedrotti, Alberto Roghi, Edgardo Bonacina, Antonella Moreo, Maurizio Bottiroli, Maria P Gagliardone, Michele Mondino, Stefano Ghio, Rossana Totaro, Fabio M Turazza, Claudio F Russo, Fabrizio Oliva, Paolo G Camici, Maria Frigerio
BACKGROUND: Previous reports have suggested that despite their dramatic presentation, patients with fulminant myocarditis (FM) might have better outcome than those with acute nonfulminant myocarditis (NFM). In this retrospective study, we report outcome and changes in left ventricular ejection fraction (LVEF) in a large cohort of patients with FM compared with patients with NFM. METHODS: The study population consists of 187 consecutive patients admitted between May 2001 and November 2016 with a diagnosis of acute myocarditis (onset of symptoms <1 month) of whom 55 required inotropes and/or mechanical circulatory support (FM) and the remaining 132 were hemodynamically stable (NFM)...
August 8, 2017: Circulation
https://www.readbyqxmd.com/read/28572050/myocarditis-in-auto-immune-or-auto-inflammatory-diseases
#8
REVIEW
Cloé Comarmond, Patrice Cacoub
Myocarditis is a major cause of heart disease in young patients and a common precursor of heart failure due to dilated cardiomyopathy. Some auto-immune and/or auto-inflammatory diseases may be accompanied by myocarditis, such as sarcoidosis, Behçet's disease, eosinophilic granulomatosis with polyangiitis, myositis, and systemic lupus erythematosus. However, data concerning myocarditis in such auto-immune and/or auto-inflammatory diseases are sparse. New therapeutic strategies should better target the modulation of the immune system, depending on the phase of the disease and the type of underlying auto-immune and/or auto-inflammatory disease...
May 29, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28546236/therapeutic-effect-of-anti-il-5-on-eosinophilic-myocarditis-with-large-pericardial-effusion
#9
Tengyao Song, David Micheal Jones, Yamen Homsi
Eosinophilic myocarditis (EM) is a rare myocardial disease that results from various eosinophilic diseases, such as idiopathic hypereosinophilic syndrome, helminth infection, medications and vasculitis. Patients with EM may present with different severities, ranging from mild symptoms to a life-threatening condition. Diagnosis of EM is a challenge and requires an extensive workup, including endomyocardial biopsy. Treatment options are limited because EM is rare and there is a lack of randomised controlled trials...
May 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28504342/sudden-death-in-a-pediatric-heart-transplant-recipient-with-peripheral-eosinophilia-and-eosinophilic-myocardial-infiltrates
#10
William McEachern, Justin Godown, Debra A Dodd, Anne I Dipchand, Jennifer L Conway, Gregory J Wilson, Robert D Hoffman
Eosinophilia has been rarely reported in pediatric heart transplant recipients and has been suggested to play a role in graft rejection. We report a case of a young female patient with peripheral blood eosinophilia who died suddenly 2 years following ABO-incompatible heart transplantation. She was found at autopsy to have myocardial infiltration of not only T-lymphocytes and macrophages expected in acute cellular rejection but also of eosinophils, B-lymphocytes, and plasma cells indicating myocarditis.
August 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28496445/eosinophils-in-autoimmune-diseases
#11
REVIEW
Nicola L Diny, Noel R Rose, Daniela Čiháková
Eosinophils are multifunctional granulocytes that contribute to initiation and modulation of inflammation. Their role in asthma and parasitic infections has long been recognized. Growing evidence now reveals a role for eosinophils in autoimmune diseases. In this review, we summarize the function of eosinophils in inflammatory bowel diseases, neuromyelitis optica, bullous pemphigoid, autoimmune myocarditis, primary biliary cirrhosis, eosinophilic granulomatosis with polyangiitis, and other autoimmune diseases...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28496024/a-survival-case-of-fulminant-right-side-dominant-eosinophilic-myocarditis
#12
Keishi Moriwaki, Kaoru Dohi, Taku Omori, Muneyoshi Tanimura, Emiyo Sugiura, Shiro Nakamori, Toshiki Sawai, Kyoko Imanaka-Yoshida, Norikazu Yamada, Masaaki Ito
A 59-year-old Japanese woman was admitted to a nearby hospital with dyspnea and general malaise. Transthoracic echocardiography revealed right ventricular (RV) dilatation with severely reduced systolic function and leftward shift of the intraventricular septum. She was initially diagnosed with acute right heart failure, and fell into cardiogenic shock requiring an intra-aortic balloon pump and inotropic agents. An endomyocardial biopsy (EMB) demonstrated extensive interstitial edema, infiltration of inflammatory cells including numerous eosinophils, and myocytolysis with eosinophil degranulation...
May 31, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28482853/dramatic-and-early-response-to-low-dose-steroid-in-the-treatment-of-acute-eosinophilic-myocarditis-a-case-report
#13
Yu-Wei Chen, Yu-Cheng Chang, Chieh-Shou Su, Wei-Chun Chang, Wen-Lieng Lee, Chih-Hung Lai
BACKGROUND: Eosinophilic myocarditis encompasses a variety of etiologies and the prognosis varies. For patients with a hypersensitive response to medications, high-dose corticosteroids and discontinuation of culprit medications are the main treatments. CASE PRESENTATION: We reported a young man with biopsy-proven eosinophilic myocarditis which was possibly induced by Chinese herbal medicine. His heart failure and left ventricular hypertrophy improved soon after low-dose corticosteroid...
May 8, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28349221/total-artificial-heart-implantation-for-biventricular-failure-due-to-eosinophilic-myocarditis
#14
Masashi Kawabori, Chitaru Kurihara, Yair Miller, Kent A Heck, Roberta C Bogaev, Andrew B Civitello, William E Cohn, O H Frazier, Jeffrey A Morgan
Idiopathic hypereosinophilic syndrome is a condition of unknown etiology characterized by proliferation of eosinophils and their infiltration into tissues. Although cardiac involvement is rare, eosinophilic myocarditis can lead to life-threating fulminant congestive heart failure. Treatment of patients with eosinophilic myocarditis is challenging as heart failure can be caused by biventricular dysfunction. To our knowledge, this is the first case reported in the literature describing a patient with acute severe biventricular heart failure caused by eosinophilic myocarditis with mural left ventricular apical thrombus who was successfully treated with implantation of a total artificial heart as a bridge to heart transplant...
March 27, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28302646/eosinophil-derived-il-4-drives-progression-of-myocarditis-to-inflammatory-dilated-cardiomyopathy
#15
Nicola L Diny, G Christian Baldeviano, Monica V Talor, Jobert G Barin, SuFey Ong, Djahida Bedja, Allison G Hays, Nisha A Gilotra, Isabelle Coppens, Noel R Rose, Daniela Čiháková
Inflammatory dilated cardiomyopathy (DCMi) is a major cause of heart failure in children and young adults. DCMi develops in up to 30% of myocarditis patients, but the mechanisms involved in disease progression are poorly understood. Patients with eosinophilia frequently develop cardiomyopathies. In this study, we used the experimental autoimmune myocarditis (EAM) model to determine the role of eosinophils in myocarditis and DCMi. Eosinophils were dispensable for myocarditis induction but were required for progression to DCMi...
April 3, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28295606/third-degree-atrioventricular-block-and-collapse-associated-with-eosinophilic-myocarditis-in-a-horse
#16
D Luethy, J Slack, M S Kraus, A R Gelzer, P Habecker, A L Johnson
Third-degree atrioventricular block (AVB) and primary inflammatory myocarditis are uncommon findings in horses. The horse of this report presented for collapse at rest and was found to have multiple cardiac arrhythmias, most notably 3rd-degree AVB. The horse was subsequently diagnosed with eosinophilic myocarditis on necropsy, a rare form of myocarditis not previously reported in horses. Despite extensive testing, an etiologic agent could not be identified, illustrating the difficulty in identifying a specific cause of myocarditis in horses...
May 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28265800/necrotizing-eosinophilic-myocarditis
#17
Martin Janík, Petr Hejna
No abstract text is available yet for this article.
June 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28246755/-brain-infarction-as-initial-manifestation-of-eosinophilic-myocarditis
#18
E Bahlmann, H van der Schalk, A Ghanem, K H Kuck, D Kivelitz, D Laßner, C Terborg
No abstract text is available yet for this article.
February 28, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28168065/rapid-change-in-mental-status-in-a-patient-with-hypereosinophilia
#19
Hanyin Wang, John K Erban
We present the case of a 48-year-old female with acute onset altered mental status, who was found to have eosinophilia, elevated troponin, and embolic strokes. Extensive testing for autoimmune, infectious, and coronary artery etiologies was unremarkable. After a cardiac MRI revealed focal myocardial hyperenhancement, the patient underwent an endomyocardial biopsy with findings consistent with eosinophilic myocarditis. The patient was diagnosed of idiopathic hypereosinophilic syndrome and started on prednisone and apixaban...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28122325/demographic-clinical-and-pathological-features-of-sudden-deaths-due-to-myocarditis-results-from-a-state-wide-population-based-autopsy-study
#20
Liliang Li, Yang Zhang, Allen Burke, Aimin Xue, Ziqin Zhao, David Fowler, Yiwen Shen, Ling Li
Causes of sudden cardiac deaths have been widely reported with limited data focused specifically on myocarditis. A retrospective review of cases from the Office of the Chief Medical Examiner (OCME), State of Maryland yielded a total of 103 sudden unexpected deaths (SUDs) due to myocarditis (0.17% of all SUDs and 0.70% of autopsied SUDs) from 2005 through 2014. Most deaths occurred in patients <30 years of age with a male:female ratio 1.3:1. Of the 103 cases, 45 (43.7%) patients were witnessed collapsed. Four deaths occurred during exertion, such as exercising at the gym or performing heavy physical work, and 2 deaths were associated with emotional stress...
March 2017: Forensic Science International
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