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Mari Romano

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https://www.readbyqxmd.com/read/28811185/the-effect-of-receptor-status-on-mastectomy-and-contralateral-prophylactic-mastectomy-rates-in-early-stage-invasive-breast-carcinoma
#1
Sunil W Dutta, Daniel M Trifiletti, Surbhi Grover, Kara D Romano, Einsley-Marie Janowski, Shayna L Showalter
BACKGROUND: There is an established relationship between hormone receptor (HR; estrogen and/or progesterone receptors) status, HER2 status, and locoregional recurrence. The purpose of this study was to analyze how HR and HER2 receptor status have influenced the surgical management trends among patients with early stage breast cancer. PATIENTS AND METHODS: The National Cancer Database was queried for patients with cT1 to cT3, cN0, and cM0 breast carcinoma from 2004 to 2012...
June 29, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28734488/clinical-fellowship-for-an-innovative-integrated-bsn-phd-program-an-academic-and-practice-partnership
#2
Madelyne Z Greene, Mary Kate FitzPatrick, Jean Romano, Linda H Aiken, Therese S Richmond
Opportunities for research-focused doctoral education must be available to nurses early in their careers in order to ensure the further development of nursing science. Early entry into the research doctorate through an integrated BSN-PhD program is one innovative approach. This approach highlights the value of integrating post-licensure clinical training into the doctoral curriculum. To better prepare innovative nurse scientists early in their careers we developed a clinical nurse fellowship within an integrated BSN-PhD program in partnership with an affiliated health system...
July 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/28716477/2017-aha-acc-key-data-elements-and-definitions-for-ambulatory-electronic-health-records-in-pediatric%C3%A2-and-congenital-cardiology-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-data-standards
#3
Jeffrey R Boris, Marie J Béland, Lisa J Bergensen, Steven D Colan, Joanna Dangel, Curtis J Daniels, Christopher Davis, Allen D Everett, Rodney Franklin, J William Gaynor, Darryl T Gray, Jennifer C Hirsch-Romano, Jeffrey P Jacobs, Marshall Jacobs, Howard Jeffries, Otto Nils Krogmann, Edwin A Lomotan, Leo Lopez, Ariane Marelli, Gerard R Martin, G Paul Matherne, Constantine Mavroudis, Ken McCardle, Gail D Pearson, Geoffrey Rosenthal, John S Scott, Gerald A Serwer, Stephen S Seslar, Robert Shaddy, Timothy Slesnick, David F Vener, Henry L Walters, Paul M Weinberg
No abstract text is available yet for this article.
July 10, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28710153/2017-aha-acc-key-data-elements-and-definitions-for-ambulatory-electronic-health-records-in-pediatric-and-congenital-cardiology-a-report-of-the-american-college-of-cardiology-american-heart-association-task-force-on-clinical-data-standards
#4
REVIEW
Jeffrey R Boris, Marie J Béland, Lisa J Bergensen, Steven D Colan, Joanna Dangel, Curtis J Daniels, Christopher Davis, Allen D Everett, Rodney Franklin, J William Gaynor, Darryl T Gray, Jennifer C Hirsch-Romano, Jeffrey P Jacobs, Marshall Jacobs, Howard Jeffries, Otto Nils Krogmann, Edwin A Lomotan, Leo Lopez, Ariane Marelli, Gerard R Martin, G Paul Matherne, Constantine Mavroudis, Ken McCardle, Gail D Pearson, Geoffrey Rosenthal, John S Scott, Gerald A Serwer, Stephen S Seslar, Robert Shaddy, Timothy Slesnick, David F Vener, Henry L Walters, Paul M Weinberg
No abstract text is available yet for this article.
August 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28706119/disparities-and-trends-in-door-to-needle-time-the-fl-pr-cresd-study-florida-puerto-rico-collaboration-to-reduce-stroke-disparities
#5
Sofia A Oluwole, Kefeng Wang, Chuanhui Dong, Maria A Ciliberti-Vargas, Carolina M Gutierrez, Li Yi, Jose G Romano, Enmanuel Perez, Brittany Ann Tyson, Maranatha Ayodele, Negar Asdaghi, Hannah Gardener, David Z Rose, Enid J Garcia, Juan Carlos Zevallos, Dianne Foster, Mary Robichaux, Salina P Waddy, Ralph L Sacco, Tatjana Rundek
BACKGROUND AND PURPOSE: In the United States, about half of acute ischemic stroke patients treated with tPA (tissue-type plasminogen activator) receive treatment within 60 minutes of hospital arrival. We aimed to determine the proportion of patients receiving tPA within 60 minutes (door-to-needle time [DTNT] ≤60) and 45 minutes (DTNT ≤45) of hospital arrival by race/ethnicity and sex and to identify temporal trends in DTNT ≤60 and DTNT ≤45. METHODS: Among 65 654 acute ischemic stroke admissions in the National Institute of Neurological Disorders and Stroke-funded FL-PR CReSD study (Florida-Puerto Rico Collaboration to Reduce Stroke Disparities) from 2010 to 2015, we included 6181 intravenous tPA-treated cases (9...
July 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28679016/stroke-hospital-characteristics-in-the-florida-puerto-rico-collaboration-to-reduce-stroke-disparities-study
#6
Maria A Ciliberti-Vargas, Hannah Gardener, Kefeng Wang, Chuanhui Dong, Li Yi, Jose G Romano, Mary Robichaux, Salina P Waddy, Ulises Nobo, Sandra Diaz-Acosta, Tatjana Rundek, Michael F Waters, Ralph L Sacco
OBJECTIVES: Although disparities in stroke care and outcomes have been well documented nationally, state-based registries to monitor acute stroke care in Florida (FL) and Puerto Rico (PR) have not been established. The FL-PR Collaboration to Reduce Stroke Disparities (CReSD) was developed to evaluate race-ethnicity and regional disparities in stroke care performance. The objective of this study was to assess and compare hospital characteristics within a large quality improvement registry to identify characteristics associated with better outcomes for acute ischemic stroke care...
July 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28628100/hotspots-of-missense-mutation-identify-neurodevelopmental-disorder-genes-and-functional-domains
#7
Madeleine R Geisheker, Gabriel Heymann, Tianyun Wang, Bradley P Coe, Tychele N Turner, Holly A F Stessman, Kendra Hoekzema, Malin Kvarnung, Marie Shaw, Kathryn Friend, Jan Liebelt, Christopher Barnett, Elizabeth M Thompson, Eric Haan, Hui Guo, Britt-Marie Anderlid, Ann Nordgren, Anna Lindstrand, Geert Vandeweyer, Antonino Alberti, Emanuela Avola, Mirella Vinci, Stefania Giusto, Tiziano Pramparo, Karen Pierce, Srinivasa Nalabolu, Jacob J Michaelson, Zdenek Sedlacek, Gijs W E Santen, Hilde Peeters, Hakon Hakonarson, Eric Courchesne, Corrado Romano, R Frank Kooy, Raphael A Bernier, Magnus Nordenskjöld, Jozef Gecz, Kun Xia, Larry S Zweifel, Evan E Eichler
Although de novo missense mutations have been predicted to account for more cases of autism than gene-truncating mutations, most research has focused on the latter. We identified the properties of de novo missense mutations in patients with neurodevelopmental disorders (NDDs) and highlight 35 genes with excess missense mutations. Additionally, 40 amino acid sites were recurrently mutated in 36 genes, and targeted sequencing of 20 sites in 17,688 patients with NDD identified 21 new patients with identical missense mutations...
August 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28586397/serum-from-dengue-virus-infected-patients-with-and-without-plasma-leakage-differentially-affects-endothelial-cells-barrier-function-in-vitro
#8
Francielle Tramontini Gomes de Sousa Cardozo, Gyulnar Baimukanova, Marion Christine Lanteri, Sheila Marie Keating, Frederico Moraes Ferreira, John Heitman, Cláudio Sérgio Pannuti, Shibani Pati, Camila Malta Romano, Ester Cerdeira Sabino
BACKGROUND: Although most of cases of dengue infections are asymptomatic or mild symptomatic some individuals present warning signs progressing to severe dengue in which plasma leakage is a hallmark. METHODOLOGY/PRINCIPAL FINDINGS: The present study used Electric Cell-substrate Impedance Sensing (ECIS®) which allows for electrical monitoring of cellular barrier function measuring changes in Transendothelial Electric Resistance (TEER) to investigate the parameters associated with dengue induced leakage...
2017: PloS One
https://www.readbyqxmd.com/read/28430723/colpocleisis-a-survey-of-current-practice-patterns
#9
Keisha Jones, Gary Wang, Robert Romano, Peter St Marie, Oz Harmanli
BACKGROUND: Currently, there are no standard treatment guidelines for colpocleisis. Clinical practice varies widely for this safe and effective procedure. OBJECTIVE: The aim of this study was to evaluate the current practice patterns in the United States among surgeons who perform colpocleisis. METHODS: A 27-item anonymous Web-based survey was sent to all practicing physicians affiliated with the American Urogynecologic Society. It consisted of questions regarding the demographic background of the physicians and their current practice as it relates to colpocleisis...
July 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28422188/resolvin-d1-enhances-the-resolution-of-lung-inflammation-caused-by-long-term-pseudomonas-aeruginosa-infection
#10
M Codagnone, E Cianci, A Lamolinara, V C Mari, A Nespoli, E Isopi, D Mattoscio, M Arita, A Bragonzi, M Iezzi, M Romano, A Recchiuti
Pseudomonas aeruginosa lung infection is a main cause of disability and mortality worldwide. Acute inflammation and its timely resolution are crucial for ensuring bacterial clearance and limiting tissue damage. Here, we investigated protective actions of resolvin (Rv) D1 in lung infection induced by the RP73 clinical strain of P. aeruginosa. RvD1 significantly diminished bacterial growth and neutrophil infiltration during acute pneumonia caused by RP73. Inoculum of RP73, immobilized in agar beads, resulted in persistent lung infection up to 21 days, leading to a non resolving inflammation reminiscent of human pathology...
April 19, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28369926/uteroplacental-insufficiency-reduces-rat-plasma-leptin-concentrations-and-alters-placental-leptin-transporters-ameliorated-with-enhanced-milk-intake-and-nutrition
#11
Jessica F Briffa, Rachael O'Dowd, Karen M Moritz, Tania Romano, Lisa R Jedwab, Andrew J McAinch, Deanne H Hryciw, Mary E Wlodek
KEY POINTS: Uteroplacental insufficiency compromises maternal mammary development, milk production and pup organ development; this is ameliorated by cross-fostering, which improves pup growth and organ development and prevents adult diseases in growth-restricted (Restricted) offspring by enhancing postnatal nutrition. Leptin is transported to the fetus from the mother by the placenta; we report reduced plasma leptin concentrations in Restricted fetuses associated with sex-specific alterations in placental leptin transporter expression...
June 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28295996/incidence-and-predictors-of-coronary-obstruction-following-transcatheter-aortic-valve-implantation-in-the-real-world
#12
Takahide Arai, Thierry Lefèvre, Thomas Hovasse, Philippe Garot, Hakim Benamer, Thierry Unterseeh, Andrew K Roy, Mauro Romano, Kentaro Hayashida, Yusuke Watanabe, Erik Bouvier, Marie-Claude Morice, Bernard Chevalier
OBJECTIVES: Coronary obstruction (CO) is a rare but serious complication of transcatheter aortic valve implantation (TAVI). There are very limited data regarding CO following TAVI. The aim of this study was to evaluate the incidence and outcomes of CO after TAVI and identify the predictors including the valve type. METHODS: Between October 2006 and March 2015, 1,203 TAVI cases were performed in our institution. Of them, 814 cases whose coronary height was measured using computed tomography for screening were analyzed in this study...
March 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28212560/use-of-complementary-and-alternative-medicine-cam-in-cancer-patients-an-italian-multicenter-survey
#13
Massimiliano Berretta, Chiara Della Pepa, Paolo Tralongo, Alberto Fulvi, Ferdinando Martellotta, Arben Lleshi, Guglielmo Nasti, Rossella Fisichella, Carmela Romano, Chiara De Divitiis, Rosaria Taibi, Francesco Fiorica, Raffaele Di Francia, Anna Di Mari, Lino Del Pup, Anna Crispo, Paolo De Paoli, Adriano Santorelli, Vincenzo Quagliariello, Rosario Vincenzo Iaffaioli, Umberto Tirelli, Gaetano Facchini
INTRODUCTION: Complementary and Alternative Medicine (CAM) include a wide range of products (herbs, vitamins, minerals, and probiotics) and medical practices, developed outside of the mainstream Western medicine. Patients with cancer are more likely to resort to CAM first or then in their disease history; the potential side effects as well as the costs of such practices are largely underestimated. PATIENTS AND METHOD: We conducted a descriptive survey in five Italian hospitals involving 468 patients with different malignancies...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28209261/the-feasibility-of-transcatheter-aortic-valve-implantation-using-the-edwards-sapien-3-for-patients-with-severe-bicuspid-aortic-stenosis
#14
Takahide Arai, Thierry Lefèvre, Thomas Hovasse, Marie-Claude Morice, Mauro Romano, Hakim Benamer, Philippe Garot, Kentaro Hayashida, Erik Bouvier, Bernard Chevalier
BACKGROUND: There are currently only limited data focusing on transcatheter aortic valve implantation (TAVI) for bicuspid aortic valves (BAV) patients using the Edwards SAPIEN (Irvine, CA, USA) 3 (S3) valve. The aim of this study was to evaluate the feasibility and efficacy of TAVI using the S3 in patients with BAV. METHODS: A total of 153 TAVI cases performed with the S3 were included. BAV was detected by multidetector computed tomography (MDCT) in 10 (7%) patients...
February 10, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28196814/racial-ethnic-disparities-in-acute-stroke-care-in-the-florida-puerto-rico-collaboration-to-reduce-stroke-disparities-study
#15
Ralph L Sacco, Hannah Gardener, Kefeng Wang, Chuanhui Dong, Maria A Ciliberti-Vargas, Carolina M Gutierrez, Negar Asdaghi, W Scott Burgin, Olveen Carrasquillo, Enid J Garcia-Rivera, Ulises Nobo, Sofia Oluwole, David Z Rose, Michael F Waters, Juan Carlos Zevallos, Mary Robichaux, Salina P Waddy, Jose G Romano, Tatjana Rundek
BACKGROUND: Racial-ethnic disparities in acute stroke care can contribute to inequality in stroke outcomes. We examined race-ethnic disparities in acute stroke performance metrics in a voluntary stroke registry among Florida and Puerto Rico Get With the Guidelines-Stroke hospitals. METHODS AND RESULTS: Seventy-five sites in the Florida Puerto Rico Stroke Registry (66 Florida and 9 Puerto Rico) recorded 58 864 ischemic stroke cases (2010-2014). Logistic regression models examined racial-ethnic differences in acute stroke performance measures and defect-free care (intravenous tissue plasminogen activator treatment, in-hospital antithrombotic therapy, deep vein thrombosis prophylaxis, discharge antithrombotic therapy, appropriate anticoagulation therapy, statin use, smoking cessation counseling) and temporal trends...
February 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28191889/targeted-sequencing-identifies-91-neurodevelopmental-disorder-risk-genes-with-autism-and-developmental-disability-biases
#16
Holly A F Stessman, Bo Xiong, Bradley P Coe, Tianyun Wang, Kendra Hoekzema, Michaela Fenckova, Malin Kvarnung, Jennifer Gerdts, Sandy Trinh, Nele Cosemans, Laura Vives, Janice Lin, Tychele N Turner, Gijs Santen, Claudia Ruivenkamp, Marjolein Kriek, Arie van Haeringen, Emmelien Aten, Kathryn Friend, Jan Liebelt, Christopher Barnett, Eric Haan, Marie Shaw, Jozef Gecz, Britt-Marie Anderlid, Ann Nordgren, Anna Lindstrand, Charles Schwartz, R Frank Kooy, Geert Vandeweyer, Celine Helsmoortel, Corrado Romano, Antonino Alberti, Mirella Vinci, Emanuela Avola, Stefania Giusto, Eric Courchesne, Tiziano Pramparo, Karen Pierce, Srinivasa Nalabolu, David G Amaral, Ingrid E Scheffer, Martin B Delatycki, Paul J Lockhart, Fereydoun Hormozdiari, Benjamin Harich, Anna Castells-Nobau, Kun Xia, Hilde Peeters, Magnus Nordenskjöld, Annette Schenck, Raphael A Bernier, Evan E Eichler
Gene-disruptive mutations contribute to the biology of neurodevelopmental disorders (NDDs), but most of the related pathogenic genes are not known. We sequenced 208 candidate genes from >11,730 cases and >2,867 controls. We identified 91 genes, including 38 new NDD genes, with an excess of de novo mutations or private disruptive mutations in 5.7% of cases. Drosophila functional assays revealed a subset with increased involvement in NDDs. We identified 25 genes showing a bias for autism versus intellectual disability and highlighted a network associated with high-functioning autism (full-scale IQ >100)...
April 2017: Nature Genetics
https://www.readbyqxmd.com/read/28164818/pediatric-and-adolescent-issues-in-underserved-populations
#17
REVIEW
Neerav Desai, Mary Elizabeth Romano
Children and adolescents in underserved populations have health care risks that are different from those of the adult population. Providers need to be aware of these needs and the available resources. Providers should work with school and community organizations to provide timely and appropriate preventive health care and screen for medical and mental health problems that occur more commonly in these high-risk patient populations.
March 2017: Primary Care
https://www.readbyqxmd.com/read/28152517/novel-hbsag-mutations-correlate-with-hepatocellular-carcinoma-hamper-hbsag-secretion-and-promote-cell-proliferation-in-vitro
#18
Romina Salpini, Matteo Surdo, Nadia Warner, Maria Francesca Cortese, Danny Colledge, Sally Soppe, Maria Concetta Bellocchi, Daniele Armenia, Luca Carioti, Fabio Continenza, Domenico Di Carlo, Patrizia Saccomandi, Carmen Mirabelli, Michela Pollicita, Roberta Longo, Sara Romano, Giuseppina Cappiello, Alberto Spanò, Pascale Trimoulet, Herve Fleury, Jacopo Vecchiet, Nerio Iapadre, Angelo Barlattani, Ada Bertoli, Terenzio Mari, Caterina Pasquazzi, Gabriele Missale, Cesare Sarrecchia, Elisa Orecchini, Alessandro Michienzi, Massimo Andreoni, Simona Francioso, Mario Angelico, Jens Verheyen, Francesca Ceccherini-Silberstein, Stephen Locarnini, Carlo Federico Perno, Valentina Svicher
BACKGROUND: An impaired HBsAg-secretion can increase HBV oncogenic-properties. Here, we investigate genetic-determinants in HBsAg correlated with HBV-induced hepatocellular carcinoma (HCC), and their impact on HBsAg-secretion and cell-proliferation. METHODS: This study included 128 chronically HBV-infected patients: 23 with HCC (73.9% D; 26.1% A HBV-genotype), and 105 without cirrhosis/HCC (72.4% D, 27.6% A) as reference-group. The impact of mutations on HBsAg-secretion was assessed by measuring the ratio [secreted/intracellular HBsAg] until day 5 post-transfection...
February 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28126188/-cell-cycle-inhibitors-in-endocrine-receptor-positive-breast-cancer
#19
Marie-Paule Sablin, Francesco Ricci, Delphine Loirat, Aude Jobard, Clémence Basse, Emanuela Romano, Christophe Le Tourneau, Véronique Dieras
Dysregulation of cellular cycle is a key component of carcinogenesis and its targeting represents an interesting approach. Recently, the development of selective inhibitors of the cycle targeting the cyclin-dependent kinases (CDK) 4 and 6 revived interest in this therapeutic class after the failure of pan-inhibitors. Palbociclib, ribociclib, and abemaciclib are the 3 drugs with the most advanced development. They demonstrated preclinical activity in luminal breast cancer models and are under clinical evaluation...
February 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28100645/lipoxin-a4-stimulates-endothelial-mir-126-5p-expression-and-its-transfer-via-microvesicles
#20
Marilina Codagnone, Antonio Recchiuti, Paola Lanuti, Anna Maria Pierdomenico, Eleonora Cianci, Sara Patruno, Veronica Cecilia Mari, Felice Simiele, Pamela Di Tomo, Assunta Pandolfi, Mario Romano
The proresolution lipid mediator lipoxin (LX)A4 bestows protective bioactions on endothelial cells. We examined the impact of LXA4 on transcellular endothelial signaling via microRNA (miR)-containing microvesicles. We report LXA4 inhibition of MV release by TNF-α-treated HUVECs, associated with the down-regulation of 18 miR in endothelial microvesicles (EMVs) and the up-regulation of miR-126-5p, both in HUVECs and in EMVs. LXA4 up-regulated miR-126-5p by ∼5-fold in HUVECs and promoted a release of microvesicles (LXA4-EMVs) that enhanced miR-126-5p by ∼7-fold in recipient HUVECs...
January 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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