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Mari Romano

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https://www.readbyqxmd.com/read/28100645/lipoxin-a4-stimulates-endothelial-mir-126-5p-expression-and-its-transfer-via-microvesicles
#1
Marilina Codagnone, Antonio Recchiuti, Paola Lanuti, Anna Maria Pierdomenico, Eleonora Cianci, Sara Patruno, Veronica Cecilia Mari, Felice Simiele, Pamela Di Tomo, Assunta Pandolfi, Mario Romano
The proresolution lipid mediator lipoxin (LX)A4 bestows protective bioactions on endothelial cells. We examined the impact of LXA4 on transcellular endothelial signaling via microRNA (miR)-containing microvesicles. We report LXA4 inhibition of MV release by TNF-α-treated HUVECs, associated with the down-regulation of 18 miR in endothelial microvesicles (EMVs) and the up-regulation of miR-126-5p, both in HUVECs and in EMVs. LXA4 up-regulated miR-126-5p by ∼5-fold in HUVECs and promoted a release of microvesicles (LXA4-EMVs) that enhanced miR-126-5p by ∼7-fold in recipient HUVECs...
January 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28070241/comparison-between-the-sapien-s3-and-the-sapien-xt-transcatheter-heart-valves-a-single-center-experience
#2
Fadi J Sawaya, Marco Spaziano, Thierry Lefèvre, Andrew Roy, Phillippe Garot, Thomas Hovasse, Antoinette Neylon, Hakim Benamer, Mauro Romano, Thierry Unterseeh, Marie-Claude Morice, Bernard Chevalier
AIM: To investigate the clinical outcomes of transcatheter aortic valve implantation (TAVI) with the SAPIEN 3 transcatheter heart valve (S3-THV) vs the SAPIEN XT valve (XT-THV). METHODS: We retrospectively analyzed 507 patients that underwent TAVI with the XT-THV and 283 patients that received the S3-THV at our institution between March 2010 and December 2015. RESULTS: Thirty-day mortality (3.5% vs 8.7%; OR = 0.44, P = 0.21) and 1-year mortality (25...
December 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/28034581/comparison-of-systematic-predilation-selective-predilation-and-direct-transcatheter-aortic-valve-implantation-with-the-sapien-s3-valve
#3
Marco Spaziano, Fadi Sawaya, Bernard Chevalier, Andrew Roy, Antoinette Neylon, Philippe Garot, Thomas Hovasse, Hakim Benamer, Mauro Romano, Thierry Unterseeh, Erik Bouvier, Bertrand Cormier, Marie-Claude Morice, Thierry Lefèvre
BACKGROUND: Despite previously described feasibility, direct transcatheter aortic valve implantation (TAVI) with the Edwards SAPIEN S3 device (S3-THV) (Edwards Lifesciences, Irvine, CA) has not been compared with either a systematic or a selective predilation approach. METHODS: Patients undergoing predilation were divided into a systematic group (regardless of anatomic features) and a selective group (in the context of high valvular calcium burden). Both groups were matched in a 2:1 fashion to patients who underwent direct TAVI...
October 4, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27970128/tct-742-transcatheter-aortic-valve-implantation-in-patients-aged-%C3%A2-75-years-versus-75-years-a-matched-comparison
#4
Marco Spaziano, Takahide Arai, Bernard Chevalier, Thomas Hovasse, Philippe Garot, Mauro Romano, Hakim Benamer, Thierry Unterseeh, Erik Bouvier, Kentaro Hayashida, Yusuke Watanabe, Bertrand Cormier, Marie-Claude Morice, Thierry Lefevre
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27969009/clinical-recommendation-vulvovaginitis
#5
Andrea Zuckerman, Mary Romano
Vulvovaginitis is a commonly encountered condition among prepubertal and adolescent females. The objective of this report is to provide the latest evidence regarding the diagnosis and management of vulvovaginitis in prepubertal and adolescent females. In this systematic review we used the Grading of Recommendations Assessment, Development and Evaluation evidence system. Vulvovaginal complaints are common in the pediatric and adolescent age group. The patient's age in conjunction with history and associated complaints will guide evaluation, diagnosis, and treatment...
December 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27909378/perspectives-of-canadian-final-year-physiotherapy-students-on-cardiorespiratory-physiotherapy-as-a-career-choice
#6
Tania Janaudis-Ferreira, Tamara Araujo, Julia Marie Romano, Pat G Camp, Mark Hall, Sunita Mathur, Dina Brooks
Purpose: To investigate the opinions of final-year Canadian physiotherapy students of cardiorespiratory physiotherapy (CRP) and the factors influencing their decision about whether to pursue a career in CRP. Methods: A cross-sectional online survey was completed by final-year Master of Science of Physical Therapy students from three of the largest English-speaking physiotherapy schools in Canada. Results: A total of 120 students responded to the survey (overall response rate was 44%). Fifteen students (12.5%) responded that they were extremely or quite interested in specializing in CRP...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27889451/diet-microbiota-interactions-mediate-global-epigenetic-programming-in-multiple-host-tissues
#7
Kimberly A Krautkramer, Julia H Kreznar, Kymberleigh A Romano, Eugenio I Vivas, Gregory A Barrett-Wilt, Mary E Rabaglia, Mark P Keller, Alan D Attie, Federico E Rey, John M Denu
Histone-modifying enzymes regulate transcription and are sensitive to availability of endogenous small-molecule metabolites, allowing chromatin to respond to changes in environment. The gut microbiota produces a myriad of metabolites that affect host physiology and susceptibility to disease; however, the underlying molecular events remain largely unknown. Here we demonstrate that microbial colonization regulates global histone acetylation and methylation in multiple host tissues in a diet-dependent manner: consumption of a "Western-type" diet prevents many of the microbiota-dependent chromatin changes that occur in a polysaccharide-rich diet...
December 1, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27884356/direct-comparison-of-feasibility-and-safety-of-transfemoral-versus-transaortic%C3%A2-versus-transapical-transcatheter-aortic%C3%A2-valve-replacement
#8
Takahide Arai, Mauro Romano, Thierry Lefèvre, Thomas Hovasse, Arnaud Farge, Daniel Le Houerou, Kentaro Hayashida, Yusuke Watanabe, Philippe Garot, Hakim Benamer, Thierry Unterseeh, Erik Bouvier, Marie-Claude Morice, Bernard Chevalier
OBJECTIVES: The aim of this study was to compare outcomes among transfemoral (TF), transaortic (TAo), and transapical (TA) transcatheter aortic valve replacement (TAVR). BACKGROUND: Very few studies have investigated the differences among TF, TAo, and TA TAVR in terms of safety and feasibility. METHODS: Between January 2011 and December 2014, 467 consecutive cases of TF TAVR, 289 cases of TAo TAVR, and 42 cases of TA TAVR were analyzed. Baseline characteristics, procedural characteristics, and outcomes were compared between TF and TAo and between TAo and TA approaches...
November 28, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27866708/mutations-in-three-genes-encoding-proteins-involved-in-hair-shaft-formation-cause-uncombable-hair-syndrome
#9
F Buket Ü Basmanav, Laura Cau, Aylar Tafazzoli, Marie-Claire Méchin, Sabrina Wolf, Maria Teresa Romano, Frederic Valentin, Henning Wiegmann, Anne Huchenq, Rima Kandil, Natalie Garcia Bartels, Arzu Kilic, Susannah George, Damian J Ralser, Stefan Bergner, David J P Ferguson, Ana-Maria Oprisoreanu, Maria Wehner, Holger Thiele, Janine Altmüller, Peter Nürnberg, Daniel Swan, Darren Houniet, Aline Büchner, Lisa Weibel, Nicola Wagner, Ramon Grimalt, Anette Bygum, Guy Serre, Ulrike Blume-Peytavi, Eli Sprecher, Susanne Schoch, Vinzenz Oji, Henning Hamm, Paul Farrant, Michel Simon, Regina C Betz
Uncombable hair syndrome (UHS), also known as "spun glass hair syndrome," "pili trianguli et canaliculi," or "cheveux incoiffables" is a rare anomaly of the hair shaft that occurs in children and improves with age. UHS is characterized by dry, frizzy, spangly, and often fair hair that is resistant to being combed flat. Until now, both simplex and familial UHS-affected case subjects with autosomal-dominant as well as -recessive inheritance have been reported. However, none of these case subjects were linked to a molecular genetic cause...
December 1, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27816319/contribution-of-a-kcnh2-variant-in-genotyped-long-qt-syndrome-romano-ward-syndrome-under-double-mutations-and-acquired-long-qt-syndrome-under-heterozygote
#10
Yusuke Fujii, Yuichi Matsumoto, Kenshi Hayashi, Wei-Guang Ding, Yukinori Tomita, Daisuke Fukumoto, Yuko Wada, Mari Ichikawa, Keiko Sonoda, Junichi Ozawa, Takeru Makiyama, Seiko Ohno, Masakazu Yamagishi, Hiroshi Matsuura, Minoru Horie, Hideki Itoh
BACKGROUND: Long QT syndrome (LQTS) presents two clinical phenotypes, congenital and acquired forms. This study aims to evaluate the genetic contribution of a KCNH2 variant for the two LQTS phenotypes. METHODS: From 1996 to 2014, genetic screening for LQTS probands was performed for five major genes: KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 and 389 probands were found to be mutation carriers. We analyzed the clinical phenotypes of p.His492Tyr carriers in KCNH2. RESULTS: Heterozygous p...
November 2, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27696351/poundbury-camp-in-context-a-new-perspective-on-the-lives-of-children-from-urban-and-rural-roman-england
#11
Anna Rohnbogner, Mary Elizabeth Lewis
OBJECTIVES: The current understanding of child morbidity in Roman England is dominated by studies of single sites/regions. Much of the data are derived from third to fifth century AD Poundbury Camp, Dorchester, Dorset, considered an unusual site due to high levels of non-adult morbidity. There is little understanding of children in rural areas, and whether Poundbury Camp was representative of Romano-British childhood. MATERIALS AND METHODS: The study provides the first large scale analysis of child health in urban and rural Roman England, adding to the previously published intra-site analysis of non-adult paleopathology at Poundbury Camp...
October 3, 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27650323/development-and-application-of-a-novel-recombinant-aleuria-aurantia-lectin-with-enhanced-core-fucose-binding-for-identification-of-glycoprotein-biomarkers-of-hepatocellular-carcinoma
#12
Pamela Norton, Mary Ann Comunale, Harmin Herrera, Mengjun Wang, Josef Houser, Michaela Wimmerova, Patrick R Romano, Anand Mehta
The Aleuria aurantia lectin (AAL) derived from orange peel fungus contains five fucose-binding sites that recognizes fucose bound in α-1,2, α-1,3, α-1,4, and α-1,6 linkages to N-acetylglucosamine and galactose. Recently, we have created several recombinant AAL (rAAL) proteins that had altered binding affinity to fucose linkages. In this report, we further characterize the binding specificity of one of the mutated lectins, N224Q lectin. This lectin was characterized by lectin Western blotting, surface plasmon resonance, and glycan microarray and shown to have increased binding to fucosylated glycan...
December 2016: Proteomics
https://www.readbyqxmd.com/read/27553032/sex-disparities-in-ischemic-stroke-care-fl-pr-cresd-study-florida-puerto-rico-collaboration-to-reduce-stroke-disparities
#13
Negar Asdaghi, Jose G Romano, Kefeng Wang, Maria A Ciliberti-Vargas, Sebastian Koch, Hannah Gardener, Chuanhui Dong, David Z Rose, Salina P Waddy, Mary Robichaux, Enid J Garcia, Juan A Gonzalez-Sanchez, W Scott Burgin, Ralph L Sacco, Tatjana Rundek
BACKGROUND AND PURPOSE: Sex-specific disparities in stroke care including thrombolytic therapy and early hospital admission are reported. In a large registry of Florida and Puerto Rico hospitals participating in the Get With The Guidelines-Stroke program, we sought to determine sex-specific differences in ischemic stroke performance metrics and overall thrombolytic treatment. METHODS: Around 51 317 (49% women) patients were included from 73 sites from 2010 to 2014...
October 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27541677/impact-of-procedural-volume-on-outcome-optimization-in-transaortic-transcatheter-aortic-valve-implantation
#14
Takahide Arai, Mauro Romano, Thierry Lefèvre, Thomas Hovasse, Erik Bouvier, Marie-Claude Morice, Arnaud Farge, Philippe Garot, Bernard Chevalier
BACKGROUND: An adequate procedural volume seems to be required to minimize the complication rate in TAVI. However, very few studies have investigated the relationship between procedural volume and outcomes in TAVI especially via the transaortic approach. The aim of this study was to evaluate the effect of procedural volume on the outcomes of transaortic TAVI (TAo-TAVI). METHODS: 257 consecutive TAo-TAVI cases performed by 2 cardiac surgeons between January 2011 and June 2014 were included in the current analysis...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27537424/ocular-onset-of-paraneoplastic-pemphigus-presenting-as-hyperemic-conjunctivitis-and-massive-bilateral-eyelid-ulceration-a-case-report-and-literature-review
#15
Raffaele Piscopo, Mary Romano, Alessandra Di Maria, Riccardo Vinciguerra, Paolo Vinciguerra
INTRODUCTION: Paraneoplastic clinical signs are characterized by a large and heterogeneous variety of manifestations due to several possible underlying neoplasms. Paraneoplastic pemphigus (PNP) is a particular paraneoplastic variety that usually primarily affects the dermic and/or oral mucosa and is characterized by a high rate of mortality (90%). Therefore, it is important to recognize its possible signs early. This report describes a case of ocular paraneoplastic pemphigus (PNP) presenting with recalcitrant eyelid ulceration and hyperemic conjunctivitis caused by an undiagnosed prostate cancer...
August 18, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27265096/erratum-to-charcot-marie-tooth-type-2-and-distal-hereditary-motor-neuropathy-clinical-neurophysiological-and-genetic-findings-from-a-single-centre-experience-clin-neurol-neurosurg-144-2016-67-71
#16
Marco Luigetti, Gian Maria Fabrizi, Giulia Bisogni, Angela Romano, Federica Taioli, Moreno Ferrarini, Daniela Bernardo, Paolo Maria Rossini, Mario Sabatelli
No abstract text is available yet for this article.
June 2, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27153360/fulranumab-in-patients-with-pain-associated-with-postherpetic-neuralgia-and-postraumatic-neuropathy-efficacy-safety-and-tolerability-results-from-a-randomized-double-blind-placebo-controlled-phase-2-study
#17
Hao Wang, Gary Romano, Margaret Fedgchin, Lucille Russell, Panna Sanga, Kathleen M Kelly, Mary Ellen Frustaci, John Thipphawong
OBJECTIVE: Fulranumab is an antibody that specifically neutralizes the biological activity of human nerve growth factor. This multicenter, phase-2, randomized, double-blind (DB), placebo-controlled study evaluated the analgesic efficacy and safety of fulranumab in postherpetic neuralgia (PHN) and posttraumatic neuropathy (PTN) patients. METHODS: Patients (18 to 80 y) with inadequately controlled moderate-to-severe pain received study medication (subcutaneous injection) every 4 weeks...
February 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/26989944/charcot-marie-tooth-type-2-and-distal-hereditary-motor-neuropathy-clinical-neurophysiological-and-genetic-findings-from-a-single-centre-experience
#18
Marco Luigetti, Gian Maria Fabrizi, Giulia Bisogni, Angela Romano, Federica Taioli, Moreno Ferrarini, Daniela Bernardo, Paolo Maria Rossini, Mario Sabatelli
OBJECTIVES: CMT is a group of heterogeneous motor and sensory neuropathies divided into demyelinating (CMT1) and axonal forms (CMT2). Distal Hereditary Motor Neuropathy (dHMN) is a motor neuropathy/neuronopathy which resembles CMT. Final genetic diagnosis is poor in CMT2 and in dHMN when compared with CMT1. Our aim is to report clinical, neurophysiological and genetic findings in a cohort of patients with axonal inherited neuropathies. PATIENTS AND METHODS: We report clinical, neurophysiological and genetic findings from 45 patients with CMT2 or dHMN, coming from 39 unrelated families, observed in our Institute of Neurology over a 20-year period...
May 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/26942287/disruption-of-pogz-is-associated-with-intellectual-disability-and-autism-spectrum-disorders
#19
Holly A F Stessman, Marjolein H Willemsen, Michaela Fenckova, Osnat Penn, Alexander Hoischen, Bo Xiong, Tianyun Wang, Kendra Hoekzema, Laura Vives, Ida Vogel, Han G Brunner, Ineke van der Burgt, Charlotte W Ockeloen, Janneke H Schuurs-Hoeijmakers, Jolien S Klein Wassink-Ruiter, Connie Stumpel, Servi J C Stevens, Hans S Vles, Carlo M Marcelis, Hans van Bokhoven, Vincent Cantagrel, Laurence Colleaux, Michael Nicouleau, Stanislas Lyonnet, Raphael A Bernier, Jennifer Gerdts, Bradley P Coe, Corrado Romano, Antonino Alberti, Lucia Grillo, Carmela Scuderi, Magnus Nordenskjöld, Malin Kvarnung, Hui Guo, Kun Xia, Amélie Piton, Bénédicte Gerard, David Genevieve, Bruno Delobel, Daphne Lehalle, Laurence Perrin, Fabienne Prieur, Julien Thevenon, Jozef Gecz, Marie Shaw, Rolph Pfundt, Boris Keren, Aurelia Jacquette, Annette Schenck, Evan E Eichler, Tjitske Kleefstra
Intellectual disability (ID) and autism spectrum disorders (ASD) are genetically heterogeneous, and a significant number of genes have been associated with both conditions. A few mutations in POGZ have been reported in recent exome studies; however, these studies do not provide detailed clinical information. We collected the clinical and molecular data of 25 individuals with disruptive mutations in POGZ by diagnostic whole-exome, whole-genome, or targeted sequencing of 5,223 individuals with neurodevelopmental disorders (ID primarily) or by targeted resequencing of this locus in 12,041 individuals with ASD and/or ID...
March 3, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/26849557/correction-foxp3-regulatory-t-cells-in-hepatic-fibrosis-and-splenomegaly-caused-by-schistosoma-japonicum-the-spleen-may-be-a-major-source-of-tregs-in-subjects-with-splenomegaly
#20
Audrey Romano, Xunya Hou, Mathieu Sertorio, Hélia Dessein, Sandrine Cabantous, Pablo Oliveira, Jun Li, Sandrine Oyegue, Violaine Arnaud, Xinsong Luo, Martine Daujat-Chavanieu, Odette Mariani, Xavier Sastre, Anne-Marie Dombey, Hongbin He, Yuesheng Li, Alain Dessein
No abstract text is available yet for this article.
February 2016: PLoS Neglected Tropical Diseases
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