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https://www.readbyqxmd.com/read/29675390/childhood-glaucoma-profile-in-dakahelia-egypt-a-retrospective-study
#1
Tharwat H Mokbel, Eman M El Hefney, Sherein M Hagras, Ahmed A ALNagdy, Amani E Badawi, Manal A Kasem, Shereen M El Shaer
AIM: To analyze childhood glaucoma regarding its demographics, presentations, different causes and surgical modalities used among patients in Dakahelia and to apply the Childhood Glaucoma Research Network (CGRN) classification retrospectively to evaluate its convenience. METHODS: A retrospective study in which the medical files of all glaucoma patients <16 years old presented to Mansoura Ophthalmic Center, Mansoura University from 2014 to 2017, were retrieved and analyzed...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29608793/a-randomized-controlled-study-on-the-accuracy-of-free-handed-pilot-drill-guided-and-fully-guided-implant-surgery-in-partially-edentulous-patients
#2
Faris Younes, Jan Cosyn, Thomas De Bruyckere, Roberto Cleymaet, Eline Bouckaert, Aryan Eghbali
AIM: To compare the accuracy of free-handed (FH), pilot-drill guided (PG) and fully-guided (FG) implant surgery. MATERIALS AND METHODS: Partially edentulous patients in need of ≥2 implants in the posterior maxilla were randomly allocated to one of the following treatment groups: FH, PG, FG. Ideal implant positions were determined in designated software following the fusion of bony information (CBCT data in DICOM format) to the prosthetic wax-up (optical scan data in STL format)...
April 2, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29420190/genome-wide-association-and-genomic-selection-for-resistance-to-amoebic-gill-disease-in-atlantic-salmon
#3
Diego Robledo, Oswald Matika, Alastair Hamilton, Ross D Houston
Amoebic gill disease (AGD) is one of the largest threats to salmon aquaculture, causing serious economic and animal welfare burden. Treatments can be expensive and environmentally damaging, hence the need for alternative strategies. Breeding for disease resistance can contribute to prevention and control of AGD, providing long-term cumulative benefits in selected stocks. The use of genomic selection can expedite selection for disease resistance due to improved accuracy compared to pedigree-based approaches...
February 2, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29400552/integrating-mammographic-breast-density-in-glandular-dose-calculation
#4
Moayyad E Suleiman, Patrick C Brennan, Ernest Ekpo, Peter Kench, Mark F McEntee
OBJECTIVE: This work proposes the use of mammographic breast density (MBD) to estimate actual glandular dose (AGD), and assesses how AGD compares to mean glandular dose (MGD) estimated using Dance et al method. METHODS: A retrospective sample of anonymised mammograms (52,405) was retrieved from a central database. Technical parameters and patient characteristics were exported from the Digital Imaging and Communication in Medicine (DICOM) header using third party software...
February 13, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29315635/association-between-paternal-alcohol-consumption-before-conception-and-anogenital-distance-of-offspring
#5
Ruilan Xia, Longmei Jin, Dekun Li, Hong Liang, Fen Yang, Jianping Chen, Wei Yuan, Maohua Miao
BACKGROUND: There are limited studies on the effects of paternal alcohol consumption, before conception, on the reproductive development of offspring. Anogenital distance (AGD), the distance from the center of the anus to the genitals, is a sensitive biomarker of reproductive hormone abnormalities during the critical developmental window. The relationship between paternal alcohol consumption and AGD of human offspring has not been studied yet. METHODS: This cohort study included 1,292 pregnant women recruited in Shanghai...
April 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29311416/average-glandular-dose-in-paired-digital-mammography-and-digital-breast-tomosynthesis-acquisitions-in-a-population-based-screening-program-effects-of-measuring-breast-density-air-kerma-and-beam-quality
#6
Bjørn Helge Østerås, Per Skaane, Randi Gullien, Anne Catrine Trægde Martinsen
The main purpose was to compare average glandular dose (AGD) for same-compression digital mammography (DM) and digital breast tomosynthesis (DBT) acquisitions in a population based screening program, with and without breast density stratification, as determined by automatically calculated breast density (Quantra™ ). Secondary, to compare AGD estimates based on measured breast density, air kerma and half value layer (HVL) to DICOM metadata based estimates. AGD was estimated for 3819 women participating in the screening trial...
January 25, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29310733/anogenital-distance-in-newborn-daughters-of-women-with-polycystic-ovary-syndrome-indicates-fetal-testosterone-exposure
#7
E S Barrett, K M Hoeger, S Sathyanarayana, D H Abbott, J B Redmon, R H N Nguyen, S H Swan
Polycystic ovary syndrome (PCOS) affects ~7% of reproductive age women. Although its etiology is unknown, in animals, excess prenatal testosterone (T) exposure induces PCOS-like phenotypes. While measuring fetal T in humans is infeasible, demonstrating in utero androgen exposure using a reliable newborn biomarker, anogenital distance (AGD), would provide evidence for a fetal origin of PCOS and potentially identify girls at risk. Using data from a pregnancy cohort (The Infant Development and Environment Study), we tested the novel hypothesis that infant girls born to women with PCOS have longer AGD, suggesting higher fetal T exposure, than girls born to women without PCOS...
January 9, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29274948/associations-of-maternal-exposure-to-organophosphate-and-pyrethroid-insecticides-and-the-herbicide-2-4-d-with-birth-outcomes-and-anogenital-distance-at-3-months-in-the-odense-child-cohort
#8
Louise Dalsager, Lisa Elmer Christensen, Malene Gjelstrup Kongsholm, Henriette Boye Kyhl, Flemming Nielsen, Greet Schoeters, Tina Kold Jensen, Helle Raun Andersen
In Odense Child Cohort (OCC), concentrations of the pesticide metabolites 3-phenoxybenzoic acid (3-PBA), 3,5,6-trichloro-2-pyridinol (TCPY), 2,4-Dichlorophenoxyacetic acid (2,4-D) and dialkyl phosphates (DAPs) were measured in urine samples collected in gestational week 28 in up to 858 women. Gestational length, birth weight, head and abdominal circumference were obtained from birth records and anogenital distance (AGD) was measured at age three month. We did not find consistent dose-related associations between pesticide metabolite concentrations and birth outcomes or AGD...
March 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29240434/fibrinogen-motif-discriminates-platelet-and-cell-capture-in-peptide-modified-gold-micropore-arrays
#9
Kellie Adamson, Elaine Spain, Una Prendergast, Niamh Moran, Robert J Forster, Tia E Keyes
Human blood platelets and SK-N-AS neuroblastoma cancer-cell capture at spontaneously adsorbed monolayers of fibrinogen-binding motifs, GRGDS (generic integrin adhesion), HHLGGAKQAGDV (exclusive to platelet integrin αIIb β3 ), or octanethiol (adhesion inhibitor) at planar gold and ordered 1.6 μm diameter spherical cap gold cavity arrays were compared. In all cases, arginine/glycine/aspartic acid (RGD) promoted capture, whereas alkanethiol monolayers inhibited adhesion. Conversely only platelets adhered to alanine/glycine/aspartic acid (AGD)-modified surfaces, indicating that the AGD motif is recognized preferentially by the platelet-specific integrin, αIIb β3 ...
January 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29229945/molecular-thresholds-of-its2-and-their-implications-for-molecular-evolution-and-species-identification-in-seed-plants
#10
Ying Qin, Meihui Li, Yong Cao, Ya Gao, Wei Zhang
Although molecular data have revealed huge amounts of plant diversity, interpreting genetic diversity into entities corresponding to species is still challenging. Taxonomic ranking based on genetic distance has been used extensively, but the results have been open to dispute, while the application of the strategy to plants has been restricted to a small number of cases. Here, levels of internal transcribed spacer 2 (ITS2) sequence variation were examined from 17,203 sequences, representing 5,439 species in 113 genera of seed plants, to ascertain the association between species status and their molecular divergence...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29218225/the-gill-parasite-paramoeba-perurans-compromises-aerobic-scope-swimming-capacity-and-ion-balance-in-atlantic-salmon
#11
Malthe Hvas, Egil Karlsbakk, Stig Mæhle, Daniel William Wright, Frode Oppedal
The parasitic amoeba Paramoeba perurans is an aetiological agent of amoebic gill disease (AGD), a serious problem in seawater salmonid aquaculture globally. Other finfish species are also infected and infection events may be associated with periods of unusual high temperatures. Currently little is known about the impact of AGD on wild fish, but in a time with global warming and increasing aquaculture production this potential threat could be on the rise. A better understanding of the pathophysiology of infected fish is therefore warranted...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/29208485/lactational-exposure-of-polychlorinated-biphenyls-impair-leydig-cellular-steroidogenesis-in-f-1-progeny-rats
#12
Sathish Kumar Thangavelu, Sugantha Priya Elaiyapillai, Ilangovan Ramachandran, Ravi Sankar Bhaskaran, Arunakaran Jagadeesan
The present study was aimed to determine the effects of lactational exposure of PCBs (Aroclor 1254) on Leydig cellular steroidogenesis in F1 progeny rats. Lactating dams were orally treated by gavage with different doses of PCBs (1, 2 and 5mg/kg b.wt./day). Male progenies were sacrificed on PND60. Our results demonstrated that exposure to PCBs decreased the body weight, testis weight and anogenital distance (AGD) index in the F1 progeny rats. Importantly, PCBs exposure reduced the serum levels of LH, testosterone and estradiol...
January 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29173906/optimization-of-the-exposure-parameters-in-digital-mammography-using-contrast-detail-metrics
#13
Leidy J Rojas, Agnes M F Fausto, Anderson W Mol, Fermin G Velasco, P O S Abreu, G Henriques, T A C Furquim
PURPOSE: Optimization studies in digital mammography aid to assure the image quality and radiological protection of the patient. The aim of this work is to test effectiveness and applicability of a method based on a Figure of Merit (FOM=(IQFinv )2 /AGD) to improve all the exposure parameters (Target/Filter combination, kVp and mAs) in order to improve the image acquisition technique that will provide the best compromise between image quality and the average glandular dose (AGD). METHODS: A contrast-detail analysis, employing the test object CDMAM, was carried out for the digital mammography unit manufactured by Lorad Hologic - model Selenia...
October 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29172721/anogenital-distance-and-variability-in-semen-parameters
#14
José J López-Espín, Consuelo Pérez-Palazón, Ana B Maldonado-Cárceles, José D Román-Arias, Jaime Mendiola, Alberto M Torres-Cantero
The purpose of this study was to analyze whether the anogenital distance (AGD) was associated with variability in semen parameters. Semen parameters analyzed following the WHO guidelines and sperm DNA fragmentation were evaluated in 160 semen samples obtained over a period of a year from 16 healthy male volunteers. Two types of AGD measurements from the anus to the rear base of the scrotum (AGDAS ) and to the cephalic insertion of the penis (AGDAP ) were taken in each individual. The association between AGDs and semen parameters were studied using three statistical tools: a) general coefficient of variation (CV) and intra-individual coefficient of variation (CVi ), b) general linear models for repeated measures, and c) mixed model fixed effects panel data...
February 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29155806/anogenital-distance-as-a-phenotypic-signature-through-infancy
#15
Lærke Priskorn, Jørgen H Petersen, Niels Jørgensen, Henriette B Kyhl, Marianne S Andersen, Katharina M Main, Anna-Maria Andersson, Niels E Skakkebaek, Tina K Jensen
BackgroundAnogenital distance (AGD) has been suggested to represent a phenotypic signature reflecting in utero androgen action. However, it is not known whether an individual's AGD at birth correlates to the AGD later in life. We investigate correlations of AGD between 3 and 18 months of age and assess reproducibility of measurements.MethodsWe measured AGD from anus to scrotum (AGDas) and to penis (AGDap) in 407 boys, and to posterior fourchette (AGDaf) and clitoris (AGDac) in 282 girls. Each measure was repeated three times at 3 and 18 months of age, and some children were, furthermore, examined by two different examiners...
December 20, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29137315/protective-effects-of-sulforaphane-on-di-n-butylphthalate-induced-testicular-oxidative-stress-injury-in-male-mice-offsprings-via-activating-nrf2-are-pathway
#16
Zhiqiang Qin, Jingyuan Tang, Peng Han, Xuping Jiang, Chengdi Yang, Ran Li, Min Tang, Baixin Shen, Wei Wang, Chao Qin, Wei Zhang
Di-N-butylphthalate (DBP) is one of the most common endocrine-disrupting chemicals which can disrupt human endocrine system, especially in the male reproductive system. Here, this study was aimed to determine whether sulforaphane (SFN) could protect against testicular oxidative stress injury induced by DBP in male mice offsprings. Wild-type (Nrf2+/+ ) and Nrf2-deficient (Nrf2-/- ) timed-pregnant mice were given DBP orally from embryonic day (E)14.5 to E19.5. Subsequently, the oxidative stress markers were evaluated...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29097052/influence-of-race-on-prenatal-phthalate-exposure-and-anogenital-measurements-among-boys-and-girls
#17
Abby G Wenzel, Michael S Bloom, Celeste D Butts, Rebecca J Wineland, John W Brock, Lori Cruze, Elizabeth R Unal, John R Kucklick, Stephen E Somerville, Roger B Newman
BACKGROUND: Select phthalates have antiandrogenic activity, which raises concern for adverse developmental outcomes given widespread exposure of pregnant women. Investigators have reported associations between maternal urinary phthalates and altered anogenital distance (AGD), a marker of in utero androgen activity, among offspring. However, data assessing the impact of race on these associations is sparse. OBJECTIVES: To evaluate associations between prenatal phthalate exposure and AGD in a racially diverse newborn population...
January 2018: Environment International
https://www.readbyqxmd.com/read/29064414/effects-of-in-utero-exposure-to-di-n-butyl-phthalate-on-testicular-development-in-rat
#18
Tan Ma, Xiaoqin Yin, Ruitong Han, Jie Ding, Huan Zhang, Xiaodong Han, Dongmei Li
Humans are inevitably exposed to ubiquitous phthalate esters (PAEs). In utero exposure to di-n-butyl phthalate (DBP) induces abnormal development of the testis and reproductive tract in male offspring, which correspond closely with the human condition of testicular dysgenesis syndrome (TDS)-like syndrome. However, the underlying mechanisms have not been elucidated in detail. In this study, pregnant rats were orally exposed to either corn oil (controls) or DBP at three different doses by gavage during Gestational Days 12...
October 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29025054/presence-of-polycystic-ovary-syndrome-is-associated-with-longer-anogenital-distance-in-adult-mediterranean-women
#19
María L Sánchez-Ferrer, Jaime Mendiola, Ana I Hernández-Peñalver, Shiana Corbalán-Biyang, Ana Carmona-Barnosi, María T Prieto-Sánchez, Aníbal Nieto, Alberto M Torres-Cantero
STUDY QUESTION: Is polycystic ovary syndrome (PCOS) associated with anogenital distance (AGD), a biomarker of fetal androgen exposure, in adult Mediterranean women? SUMMARY ANSWER: Longer AGD is associated with PCOS in adult Mediterranean women. WHAT IS KNOWN ALREADY: AGD is a biomarker of prenatal androgen milieu. Human observational studies have reported that associations between AGD and reproductive parameters in both sexes. Exposure of the female fetus to intrauterine androgens may be a risk factor for PCOS in adulthood...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28974865/quality-assurance-and-average-glandular-dose-measurement-in-mammography-units
#20
C Senthamil Selvan, C S Sureka
To ensure the safe operation of mammography units, acceptance tests and quality assurance (QA) protocols have been developed by the American Association of Physicists in Medicine (AAPM), Engineers Registration Board, and International Atomic Energy Agency. Eight mammography units manufactured by five different manufacturers located in hospitals in our region were investigated following the AAPM and Atomic Energy Regulatory Board (AERB) protocols using a solid-state dosimeter-based PTW-NOMEX Multimeter and a metal-oxide-semiconductor field-effect transistor...
July 2017: Journal of Medical Physics
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