Ana-Caroline Raulin, Sydney V Doss, Michael G Heckman, Emily C Craver, Zonghua Li, Tadafumi C Ikezu, Hiroaki Sekiya, Chia-Chen Liu, Yuka A Martens, Cassandra L Rosenberg, Lindsey A Kuchenbecker, Michael DeTure, R Ross Reichard, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Emmaline K Kounaves, Melissa E Murray, Dennis W Dickson, Ronald C Petersen, Guojun Bu, Takahisa Kanekiyo
Alzheimer's disease (AD), characterized by the deposition of amyloid-β (Aβ) in senile plaques and neurofibrillary tangles of phosphorylated tau (pTau), is increasingly recognized as a complex disease with multiple pathologies. AD sometimes pathologically overlaps with age-related tauopathies such as four repeat (4R)-tau predominant argyrophilic grain disease (AGD). While AGD is often detected with AD pathology, the contribution of APOE4 to AGD risk is not clear despite its robust effects on AD pathogenesis...
February 9, 2024: Acta Neuropathologica Communications