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https://www.readbyqxmd.com/read/29218225/the-gill-parasite-paramoeba-perurans-compromises-aerobic-scope-swimming-capacity-and-ion-balance-in-atlantic-salmon
#1
Malthe Hvas, Egil Karlsbakk, Stig Mæhle, Daniel William Wright, Frode Oppedal
The parasitic amoeba Paramoeba perurans is an aetiological agent of amoebic gill disease (AGD), a serious problem in seawater salmonid aquaculture globally. Other finfish species are also infected and infection events may be associated with periods of unusual high temperatures. Currently little is known about the impact of AGD on wild fish, but in a time with global warming and increasing aquaculture production this potential threat could be on the rise. A better understanding of the pathophysiology of infected fish is therefore warranted...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/29208485/lactational-exposure-of-polychlorinated-biphenyls-impairs-leydig-cellular-steroidogenesis-in-f1-progeny-rats
#2
Sathish Kumar Thangavelu, Sugantha Priya Elaiyapillai, Ilangovan Ramachandran, Ravi Sankar Bhaskaran, Arunakaran Jagadeesan
The present study was aimed to determine the effects of lactational exposure of PCBs (Aroclor 1254) on Leydig cellular steroidogenesis in F1 progeny rats. Lactating dams were orally treated by gavage with different doses of PCBs (1, 2 and 5mg/kg b.wt./day). Male progenies were sacrificed on PND60. Our results demonstrated that exposure to PCBs decreased the body weight, testis weight and anogenital distance (AGD) index in the F1 progeny rats. Importantly, PCBs exposure reduced the serum levels of LH, testosterone and estradiol...
December 2, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/29173906/optimization-of-the-exposure-parameters-in-digital-mammography-using-contrast-detail-metrics
#3
Leidy J Rojas, Agnes M F Fausto, Anderson W Mol, Fermin G Velasco, P O S Abreu, G Henriques, T A C Furquim
PURPOSE: Optimization studies in digital mammography aid to assure the image quality and radiological protection of the patient. The aim of this work is to test effectiveness and applicability of a method based on a Figure of Merit (FOM=(IQFinv)2/AGD) to improve all the exposure parameters (Target/Filter combination, kVp and mAs) in order to improve the image acquisition technique that will provide the best compromise between image quality and the average glandular dose (AGD). METHODS: A contrast-detail analysis, employing the test object CDMAM, was carried out for the digital mammography unit manufactured by Lorad Hologic - model Selenia...
October 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29172721/anogenital-distance-and-variability-in-semen-parameters
#4
José J López-Espín, Consuelo Pérez-Palazón, Ana B Maldonado-Cárceles, José D Román-Arias, Jaime Mendiola, Alberto M Torres-Cantero
The purpose of this study was to analyze whether the anogenital distance (AGD) was associated with variability in semen parameters. Semen parameters analyzed following the WHO guidelines and sperm DNA fragmentation were evaluated in 160 semen samples obtained over a period of a year from 16 healthy male volunteers. Two types of AGD measurements from the anus to the rear base of the scrotum (AGDAS) and to the cephalic insertion of the penis (AGDAP) were taken in each individual. The association between AGDs and semen parameters were studied using three statistical tools: a) general coefficient of variation (CV) and intra-individual coefficient of variation (CVi), b) general linear models for repeated measures, and c) mixed model fixed effects panel data...
November 27, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29155806/anogenital-distance-as-a-phenotypic-signature-through-infancy
#5
Lærke Priskorn, Jørgen H Petersen, Niels Jørgensen, Henriette B Kyhl, Marianne S Andersen, Katharina M Main, Anna-Maria Andersson, Niels E Skakkebaek, Tina K Jensen
BACKGROUND: Anogenital distance (AGD) has been suggested to represent a phenotypic signature reflecting in utero androgen action. However, it is not known whether an individual's AGD at birth correlates to AGD later in life. We investigate correlations of AGD between 3 and 18 months and asses reproducibility of measurements. METHODS: We measured AGD from anus to scrotum (AGDas) and penis (AGDap) in 407 boys, and to posterior fourchette (AGDaf) and clitoris (AGDac) in 282 girls...
November 20, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29137315/protective-effects-of-sulforaphane-on-di-n-butylphthalate-induced-testicular-oxidative-stress-injury-in-male-mice-offsprings-via-activating-nrf2-are-pathway
#6
Zhiqiang Qin, Jingyuan Tang, Peng Han, Xuping Jiang, Chengdi Yang, Ran Li, Min Tang, Baixin Shen, Wei Wang, Chao Qin, Wei Zhang
Di-N-butylphthalate (DBP) is one of the most common endocrine-disrupting chemicals which can disrupt human endocrine system, especially in the male reproductive system. Here, this study was aimed to determine whether sulforaphane (SFN) could protect against testicular oxidative stress injury induced by DBP in male mice offsprings. Wild-type (Nrf2+/+) and Nrf2-deficient (Nrf2-/-) timed-pregnant mice were given DBP orally from embryonic day (E)14.5 to E19.5. Subsequently, the oxidative stress markers were evaluated...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29097052/influence-of-race-on-prenatal-phthalate-exposure-and-anogenital-measurements-among-boys-and-girls
#7
Abby G Wenzel, Michael S Bloom, Celeste D Butts, Rebecca J Wineland, John W Brock, Lori Cruze, Elizabeth R Unal, John R Kucklick, Stephen E Somerville, Roger B Newman
BACKGROUND: Select phthalates have antiandrogenic activity, which raises concern for adverse developmental outcomes given widespread exposure of pregnant women. Investigators have reported associations between maternal urinary phthalates and altered anogenital distance (AGD), a marker of in utero androgen activity, among offspring. However, data assessing the impact of race on these associations is sparse. OBJECTIVES: To evaluate associations between prenatal phthalate exposure and AGD in a racially diverse newborn population...
January 2018: Environment International
https://www.readbyqxmd.com/read/29064414/effects-of-in-utero-exposure-to-di-n-butyl-phthalate-on-testicular-development-in-rat
#8
Tan Ma, Xiaoqin Yin, Ruitong Han, Jie Ding, Huan Zhang, Xiaodong Han, Dongmei Li
Humans are inevitably exposed to ubiquitous phthalate esters (PAEs). In utero exposure to di-n-butyl phthalate (DBP) induces abnormal development of the testis and reproductive tract in male offspring, which correspond closely with the human condition of testicular dysgenesis syndrome (TDS)-like syndrome. However, the underlying mechanisms have not been elucidated in detail. In this study, pregnant rats were orally exposed to either corn oil (controls) or DBP at three different doses by gavage during Gestational Days 12...
October 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29025054/presence-of-polycystic-ovary-syndrome-is-associated-with-longer-anogenital-distance-in-adult-mediterranean-women
#9
María L Sánchez-Ferrer, Jaime Mendiola, Ana I Hernández-Peñalver, Shiana Corbalán-Biyang, Ana Carmona-Barnosi, María T Prieto-Sánchez, Aníbal Nieto, Alberto M Torres-Cantero
STUDY QUESTION: Is polycystic ovary syndrome (PCOS) associated with anogenital distance (AGD), a biomarker of fetal androgen exposure, in adult Mediterranean women? SUMMARY ANSWER: Longer AGD is associated with PCOS in adult Mediterranean women. WHAT IS KNOWN ALREADY: AGD is a biomarker of prenatal androgen milieu. Human observational studies have reported that associations between AGD and reproductive parameters in both sexes. Exposure of the female fetus to intrauterine androgens may be a risk factor for PCOS in adulthood...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28974865/quality-assurance-and-average-glandular-dose-measurement-in-mammography-units
#10
C Senthamil Selvan, C S Sureka
To ensure the safe operation of mammography units, acceptance tests and quality assurance (QA) protocols have been developed by the American Association of Physicists in Medicine (AAPM), Engineers Registration Board, and International Atomic Energy Agency. Eight mammography units manufactured by five different manufacturers located in hospitals in our region were investigated following the AAPM and Atomic Energy Regulatory Board (AERB) protocols using a solid-state dosimeter-based PTW-NOMEX Multimeter and a metal-oxide-semiconductor field-effect transistor...
July 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28944485/effect-of-repeated-exposure-to-aqui-s-%C3%A2-on-the-viability-and-growth-of-neoparamoeba-perurans
#11
R J Chance, Z Allcock, C J Secombes, B Collet, C Collins
There have been recent efforts amongst immunologists to develop approaches for following individual fish during challenges with viral and bacterial pathogens. This study contributes to assessing the feasibility of using such approaches to study amoebic gill disease (AGD). Neoparamoeba perurans, agent of AGD, has been responsible for widespread economic and fish loss in salmonid aquaculture. With the emergence of AGD in Europe, research into infection dynamics and host response has increased. This study investigated the effect of repeat exposure to anaesthesia, a necessary requirement when following disease progression in individual fish, on N...
September 25, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28942447/anogenital-distance-in-term-newborns-in-kumasi-ghana
#12
Serwah Bonsu Asafo-Agyei, Emmanuel Ameyaw, Jean-Pierre Chanoine, Margaret Zacharin, Samuel Blay Nguah, Olumide Olatokunbo Jarrett
BACKGROUND: Anogenital distance (AGD) is a simple noninvasive measure of foetal androgen exposure. This study was done to generate normative data on AGD in Ghanaian newborns. METHODS: AGD was measured in 644 male and 612 female term newborns; including the distance between the anterior base of the penis and the centre of the anus, the posterior base of the penis and the centre of the anus, and the posterior base of the scrotum and the centre of the anus (ASD) in males and the distance from the anus to the fourchette (AF) and from the anus to the base of the clitoris in females...
September 22, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28941819/characterization-of-anogenital-distance-and-its-relationship-to-fertility-in-lactating-holstein-cows
#13
M Gobikrushanth, T C Bruinjé, M G Colazo, S T Butler, D J Ambrose
Anogenital distance (AGD) serves as a marker for prenatal androgenization, reproductive development, and fertility in humans and rodents. The primary objectives of this observational study in lactating dairy cows were to (1) characterize the distribution and variability of AGD, (2) determine the relationship among AGD and potential postnatal AGD determinants of age and height, and (3) evaluate the associations between AGD and pregnancy to first artificial insemination (P/AI) and cumulative pregnancy by 250 d in milk (DIM) within parity groups (first, second, and third+ parities)...
September 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28915034/affinity-guided-oxime-chemistry-for-selective-protein-acylation-in-live-tissue-systems
#14
Tomonori Tamura, Zhining Song, Kazuma Amaike, Shin Lee, Sifei Yin, Shigeki Kiyonaka, Itaru Hamachi
Catalyst-mediated protein modification is a powerful approach for the imaging and engineering of natural proteins. We have previously developed affinity-guided 4-dimethylaminopyridine (AGD) chemistry as an efficient protein modification method using a catalytic acyl transfer reaction. However, because of the high electrophilicity of the thioester acyl donor molecule, AGD chemistry suffers from nonspecific reactions to proteins other than the target protein in crude biological environments, such as cell lysates, live cells, and tissue samples...
October 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28906054/neuropathological-comorbidity-associated-with-argyrophilic-grain-disease
#15
REVIEW
Osamu Yokota, Tomoko Miki, Chikako Ikeda, Shigeto Nagao, Shintaro Takenoshita, Hideki Ishizu, Takashi Haraguchi, Shigetoshi Kuroda, Seishi Terada, Norihito Yamada
Argyrophilic grain disease (AGD) is a common four-repeat tauopathy in elderly people. While dementia is a major clinical picture of AGD, recent studies support the possibility that AGD may be a pathological base in some patients with mild cognitive impairment, late-onset psychosis, bipolar disorder and depression. AGD often coexists with various other degenerative changes. The frequency of AGD in progressive supranuclear palsy (PSP) cases was reported to range from 18.8% to 80%. The frequency of AGD in corticobasal degeneration (CBD) cases tends to be higher than that in PSP cases, ranging from 41...
September 14, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28870779/epitestosterone-and-testosterone-replacement-in-immature-castrated-rats-changes-main-testicular-developmental-characteristics
#16
Fernanda Carvalho Cavalari, Luciana Abreu da Rosa, Gustavo Monteiro Escott, Tadeu Dourado, Alexandre Luz de Castro, Maria Beatriz da Fonte Kohek, Maria Flávia Marques Ribeiro, Wania Aparecida Partata, Luciano Stürmer de Fraga, Eloísa da Silveira Loss
Epitestosterone is the 17α-epimer of testosterone and has been described as an anti-androgen, since it inhibits the effects produced by testosterone and dihydrotestosterone via the nuclear androgen receptor (nAR). However, epitestosterone also displays an effect which is similar to the non-classical effect of testosterone, depolarizing the membrane potential of Sertoli cells and inducing a rapid Ca(2+) uptake. This study aimed to investigate the effects of a treatment with epitestosterone on developmental parameters of immature rats...
September 1, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28870087/impact-on-dose-and-image-quality-of-a-software-based-scatter-correction-in-mammography
#17
Teresa Monserrat, Elena Prieto, Benigno Barbés, Luis Pina, Arlette Elizalde, Belén Fernández
Background In 2014, Siemens developed a new software-based scatter correction (Progressive Reconstruction Intelligently Minimizing Exposure [PRIME]), enabling grid-less digital mammography. Purpose To compare doses and image quality between PRIME (grid-less) and standard (with anti-scatter grid) modes. Material and Methods Contrast-to-noise ratio (CNR) was measured for various polymethylmethacrylate (PMMA) thicknesses and dose values provided by the mammograph were recorded. CDMAM phantom images were acquired for various PMMA thicknesses and inverse Image Quality Figure (IQFinv) was calculated...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28854868/comparative-developmental-toxicity-evaluation-of-di-n-hexyl-phthalate-and-dicyclohexyl-phthalate-in-rats
#18
Müfide Aydogan Ahbab, Celal Güven, Evrim Arzu Koçkaya, Nurhayat Barlas
To investigate the effects of di- n-hexyl phthalate (DHP) and dicyclohexyl phthalate (DCHP) on the development of fetus and placenta in utero, pregnant rats were exposed to DHP or DCHP at dosages of 0, 20, 100, and 500 mg/kg bw/day, by gavage, on gestational days 6-19. Anogenital distance (AGD) and AGD-body weight(1/3) ratio of female fetuses decreased in all treatment groups in a non-dose-response way. The ossification centers of bones and the intensity of Alizarin red stain of the fetuses decreased in all treatment groups...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28843704/anogenital-distance-a-longitudinal-evaluation-of-its-variants-and-indices-in-boys-and-girls-of-sonora-mexico
#19
Carmen Loreto-Gómez, Paulina Farías, Hortensia Moreno-Macías, S P Romano-Riquer, Horacio Riojas-Rodríguez
There is no consensus on which anogenital distance (AGD) variant to use and how to adjust it by body size in humans. This study quantitatively evaluated AGD variants and body size adjustments to determine which would be the best choice. AGD variants, height, and weight were measured on five occasions during the first year of life of 307 infants. The ratio of anoscrotal distance (ASD) in boys and anofourchette distance (AFD) in girls increased from 1.9 at birth to 2.3 at 12 months of age. Each AGD variant was divided by each body size variable to generate different indices...
August 23, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28743560/fertility-and-anogenital-distance-in-women
#20
Tamar Wainstock, Ilana Shoham-Vardi, Eyal Sheiner, Asnat Walfisch
BACKGROUND: Human and animal studies have found an association between prenatal androgen exposure and the anogenital distance (AGD). The aims of this study were to study the association between female AGD, reproductive health and background characteristics. METHODS: This was a cross sectional study, in which AGD were measured in 300 pregnant women who were recruited early during the first stage of labor. Demographic and health characteristics were collected and studied in association with AGD measurements...
July 22, 2017: Reproductive Toxicology
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