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https://www.readbyqxmd.com/read/28196105/adaptive-geostatistical-sampling-enables-efficient-identification-of-malaria-hotspots-in-repeated-cross-sectional-surveys-in-rural-malawi
#1
Alinune N Kabaghe, Michael G Chipeta, Robert S McCann, Kamija S Phiri, Michèle van Vugt, Willem Takken, Peter Diggle, Anja D Terlouw
INTRODUCTION: In the context of malaria elimination, interventions will need to target high burden areas to further reduce transmission. Current tools to monitor and report disease burden lack the capacity to continuously detect fine-scale spatial and temporal variations of disease distribution exhibited by malaria. These tools use random sampling techniques that are inefficient for capturing underlying heterogeneity while health facility data in resource-limited settings are inaccurate...
2017: PloS One
https://www.readbyqxmd.com/read/28123099/teratogenic-effects-of-in-utero-exposure-to-di-2-ethylhexyl-phthalate-dehp-in-b6-129s4-mice
#2
Erica Ungewitter, Emmi Rotgers, Tanika Bantukul, Yasuhiko Kawakami, Grace E Kissling, Humphrey Hung-Chang Yao
Intrauterine exposure to phthalates is known to cause disorders of male reproductive function including androgen insufficiency, decreased fertility, and germ cell defects in rodents. In this study, we set out to investigate the effects of intrauterine exposure to di-(2-ethylhexyl)-phthalate (DEHP) on fetal development of the B6:129S4 mouse strain. Time-mated pregnant C57BL/6 dams were exposed to 0, 5, 250, or 500 mg/kg DEHP with corn oil as the vehicle via oral gavage from embryonic days (E)7 to 16. Survival and gross morphology of the pups were analyzed one day after the last treatment...
January 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28112559/breast-radiation-dose-with-cesm-compared-with-2d-ffdm-and-3d-tomosynthesis-mammography
#3
COMPARATIVE STUDY
Judy R James, William Pavlicek, James A Hanson, Thomas F Boltz, Bhavika K Patel
OBJECTIVE: We aimed to compare radiation dose received during contrast-enhanced spectral mammography (CESM) using high- and low-energy projections with radiation dose received during 2D full field digital mammography (FFDM) and 3D tomosynthesis on phantoms and patients with varying breast thickness and density. MATERIALS AND METHODS: A single left craniocaudal projection was chosen to determine the doses for 6214 patients who underwent 2D FFDM, 3662 patients who underwent 3D tomosynthesis, and 173 patients who underwent CESM in this retrospective study...
February 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28109703/investigation-of-anogenital-distance-as-a-diagnostic-tool-in-endometriosis
#4
Maria L Sánchez-Ferrer, Jaime Mendiola, Raquel Jiménez-Velázquez, Laura Cánovas-López, Shiana Corbalán-Biyang, Ana I Hernández-Peñalver, Ana Carmona-Barnosi, Ana B Maldonado-Cárceles, Maria T Prieto-Sánchez, Francisco Machado-Linde, Anibal Nieto, Alberto M Torres-Cantero
An association between anogenital distance (AGD) and endometriosis has been reported, suggesting that AGD may be a useful clinical tool in endometriosis. The predictive ability of AGD of women in discriminating presence and type of endometriosis was examined. A case-control study was conducted at the University Hospital 'Virgen de la Arrixaca', Murcia, Spain, between 2014 and 2015. A total of 114 participants diagnosed with endometriosis using ultrasound findings and 105 controls were recruited. Two AGD measurements were obtained: one from the anterior clitoral surface to the upper verge of the anus (AGDAC), and another one from the posterior fourchette to the upper verge of the anus (AGDAF)...
January 10, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28077271/occupational-exposure-to-pesticides-reproductive-hormone-levels-and-sperm-quality-in-young-brazilian-men
#5
Cleber Cremonese, Camila Piccoli, Fabio Pasqualotto, Ruth Clapauch, Rosalina Jorge Koifman, Sergio Koifman, Carmen Freire
The association of occupational exposure to current-use pesticides with reproductive hormones, semen quality, and genital measures was investigated among young men in the South of Brazil. A cross-sectional study was conducted in 99 rural and 36 urban men aged 18-23 years. Information on pesticide use was obtained through questionnaire. Serum and semen samples were analyzed for sex hormones and sperm parameters, respectively, and measurement of anogenital distance (AGD) and testis volume (TV) were performed...
January 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28048898/mo-fg-brc-03-design-and-construction-of-a-dielectiric-wall-accelerator
#6
D Westerly
Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048246/mo-fg-brc-04-ionacoustic-imaging-for-particle-range-verification
#7
K Parodi
Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047813/su-d-209-07-measure-the-average-glandular-dose-of-a-2d-3d-breast-imaging-protocol-using-ge-senoclaire-breast-tomosynthesis-system
#8
Y Liang, A Dutta
PURPOSE: To measure the average glandular dose (AGD) of a 2D+3D breast imaging protocol using GE SenoClaire breast tomosynthesis system. METHODS: This study used a GE SenoClaire breast tomosynthesis unit, a Gammex ACR mammography accreditation phantom, 5 cm thick PMMA phantom, an Unfors RaySafe X2 mammography detector. The breast imaging protocol includes a regular 2D CC view and a 3D MLO view at 45 degree, using AUTO mode. Both ACR phantom and PMMA phantom were scanned under AUTO mode with 10 daN compression to obtain the techniques of 2D CC view, 3D MLO view, and 3D CC view...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047462/mo-fg-brc-00-joint-aapm-estro-symposium-advances-in-experimental-medical-physics
#9
Ross Berbeco, Dan Ionascu
Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047254/tu-d-209-01-dosimetry-of-diagnostic-work-up-mammography
#10
N Jallow, I Sechopoulos
PURPOSE: To investigate patient average glandular dose (AGD) characteristics of diagnostic mammography. METHODS: The techniques used to image 14420 patients who received diagnostic work up mammography from October 2008 to December 2014 at one academic hospital were retrospectively collected. The most common diagnostic views and the techniques used for each according to compressed breast thickness were determined. For all techniques, 1st half value layer and air kerma output per tube current-exposure time product were measured; then the incident air kerma for each acquisition was calculated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046835/mo-fg-brc-02-low-z-switching-linear-accelerator-targets-new-options-for-image-guidance-and-dose-enhancement-in-radiotherapy
#11
J Robar
Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046808/mo-fg-brc-01-mr-guided-radiation-therapy-with-gadolinium-nanoparticles-from-chalkboard-to-first-clinical-trials
#12
L Sancey
Experimental research in medical physics has expanded the limits of our knowledge and provided novel imaging and therapy technologies for patients around the world. However, experimental efforts are challenging due to constraints in funding, space, time and other forms of institutional support. In this joint ESTRO-AAPM symposium, four exciting experimental projects from four different countries are highlighted. Each project is focused on a different aspect of radiation therapy. From the USA, we will hear about a new linear accelerator concept for more compact and efficient therapy devices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041790/impairment-of-microvascular-angiogenesis-is-associated-with-delay-in-prostatic-development-in-rat-offspring-of-maternal-protein-malnutrition
#13
Ketlin T Colombelli, Sérgio A A Santos, Ana C L Camargo, Flávia B Constantino, Caroline N Barquilha, Jaqueline C Rinaldi, Sérgio L Felisbino, Luis A Justulin
Experimental data demonstrated the negative impact of maternal protein malnutrition (MPM) on rat prostate development, but the mechanism behind the impairment of prostate growth has not been well understood. Male Sprague Dawley rats, borned to dams fed a normal protein diet (CTR group, 17% protein diet), were compared with those borned from dams fed a low protein diet (6% protein diet) during gestation (GLP group) or gestation and lactation (GLLP). The ventral prostate lobes (VP) were removed at post-natal day (PND) 10 and 21, and analyzed via different methods...
December 29, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28025160/characterisation-of-arginase-paralogues-in-salmonids-and-their-modulation-by-immune-stimulation-infection
#14
Ottavia Benedicenti, Tiehui Wang, Eakapol Wangkahart, Douglas J Milne, Jason W Holland, Catherine Collins, Christopher J Secombes
In this study we show that four arginase isoforms (arg1a, arg1b, arg2a, arg2b) exist in rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar). We have characterised these molecules in terms of a) sequence analysis, b) constitutive expression in different tissues, and modulated expression following c) stimulation of head kidney macrophages in vitro, or d) vaccination/infection with Yersinia ruckeri and e) parasite infection (AGD caused by Paramoeba perurans and PKD caused by Tetracapsuloides bryosalmonae)...
February 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28010921/digital-breast-tomosynthesis-dose-and-image-quality-assessment
#15
A Maldera, P De Marco, P E Colombo, D Origgi, A Torresin
The aim of this work was to evaluate how different acquisition geometries and reconstruction parameters affect the performance of four digital breast tomosynthesis (DBT) systems (Senographe Essential - GE, Mammomat Inspiration - Siemens, Selenia Dimensions - Hologic and Amulet Innovality - Fujifilm) on the basis of a physical characterization. Average Glandular Dose (AGD) and image quality parameters such as in-plane/in-depth resolution, signal difference to noise ratio (SDNR) and artefact spread function (ASF) were examined...
January 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28002858/is-individualizing-breast-compression-during-mammography-useful-investigations-of-pain-indications-during-mammography-relating-to-compression-force-and-surface-area-of-the-compressed-breast
#16
Katarzyna Feder, Jens-Holger Grunert
Purpose The aim of this paper is to determine how the presence of pain during mammographic compression could be reduced. To this end, we examine its relationship with compression force, surface-area of the compressed breast, breast density (ACR) and former operations. Materials and Methods In 199 women 765 mammograms were performed. Women were asked to rate the level of pain on a scale of 0 - 10 (0: no, 10: highest pain). The surface-area of the breast under compression captured by the mammograms was measured using planimetry...
January 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/27911827/tau-prions-from-alzheimer-s-disease-and-chronic-traumatic-encephalopathy-patients-propagate-in-cultured-cells
#17
Amanda L Woerman, Atsushi Aoyagi, Smita Patel, Sabeen A Kazmi, Iryna Lobach, Lea T Grinberg, Ann C McKee, William W Seeley, Steven H Olson, Stanley B Prusiner
Tau prions are thought to aggregate in the central nervous system, resulting in neurodegeneration. Among the tauopathies, Alzheimer's disease (AD) is the most common, whereas argyrophilic grain disease (AGD), corticobasal degeneration (CBD), chronic traumatic encephalopathy (CTE), Pick's disease (PiD), and progressive supranuclear palsy (PSP) are less prevalent. Brain extracts from deceased individuals with PiD, a neurodegenerative disorder characterized by three-repeat (3R) tau prions, were used to infect HEK293T cells expressing 3R tau fused to yellow fluorescent protein (YFP)...
December 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27896452/optimization-of-image-quality-and-dose-in-digital-mammography
#18
Agnes M F Fausto, M C Lopes, M C de Sousa, Tânia A C Furquim, Anderson W Mol, Fermin G Velasco
Nowadays, the optimization in digital mammography is one of the most important challenges in diagnostic radiology. The new digital technology has introduced additional elements to be considered in this scenario. A major goal of mammography is related to the detection of structures on the order of micrometers (μm) and the need to distinguish the different types of tissues, with very close density values. The diagnosis in mammography faces the difficulty that the breast tissues and pathological findings have very close linear attenuation coefficients within the energy range used in mammography...
November 28, 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/27872679/the-oxidative-and-inflammatory-state-in-patients-with-acute-renal-graft-dysfunction-treated-with-tacrolimus
#19
Sandra Carrillo-Ibarra, José Ignacio Cerrillos-Gutiérrez, Ariadna Escalante-Núñez, Enrique Rojas-Campos, Benjamín Gómez-Navarro, Sonia Sifuentes-Franco, Ernesto Germán Cardona-Muñoz, Alejandra Guillermina Miranda-Díaz
Objective. To determine the oxidative stress/inflammation behavior in patients with/without acute graft dysfunction (AGD) with Tacrolimus. Methods. Cross-sectional study, in renal transplant (RT) recipients (1-yr follow-up). Patients with AGD and without AGD were included. Serum IL-6, TNF-α, 8-isoprostanes (8-IP), and Nitric Oxide (NO) were determined by ELISA; C-reactive protein (CRP) was determined by nephelometry; lipid peroxidation products (LPO) and superoxide dismutase (SOD) were determined by colorimetry...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27862129/anogenital-distance-a-biomarker-of-prenatal-androgen-exposure-is-associated-with-prostate-cancer-severity
#20
Ana B Maldonado-Cárceles, Carlos Sánchez-Rodríguez, Eva M Vera-Porras, Julián J Árense-Gonzalo, Julián Oñate-Celdrán, Paula Samper-Mateo, Damián García-Escudero, Marcos Torres-Roca, Francisco Martínez-Díaz, Jaime Mendiola, Alberto M Torres-Cantero
BACKGROUND: Anogenital distance (AGD), the distance from the centre of the anus to the genitals, is a sexually dimorphic phenotype in mammals. Experimental studies have shown that AGD is a biomarker of prenatal androgen exposure during the masculinisation period of development. The aim of this study is to assess the relationship between anogenital distance (AGD), as an indirect marker of prenatal hormonal environment, and prostate cancer (PCa) severity. MATERIALS: We conducted a cross-sectional study with a total of 120 PCa patients with confirmed biopsy of the tumour from April 2007 to July 2015...
November 16, 2016: Prostate
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