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dose reference level

Jixiang Wang, Yuliang Zhang, Zhenzhen Guo, Rui Li, Xingchen Xue, Zilong Sun, Ruiyan Niu
To investigate the effects of perinatal fluoride exposure on learning and memory ability of mouse offspring, ICR female mice were received different doses of sodium fluoride (0, 25, 50, 100 mg/L NaF) from pregnant day 7 to lactational day 21. Pups were exposed to fluoride through the cord blood and breast milk. Open field test showed that compared to the control group, perinatal fluoride exposure significantly decreased the number of entries into the center zone in 100 mg/L NaF group. In the eight-arm maze test, the number of working memory errors, reference memory errors, and the total arm entries were significantly increased in fluoride treatment groups, compared to the control group...
January 8, 2018: Chemosphere
K K Fjukstad, A Engum, S Lydersen, I Dieset, N Eiel Steen, O A Andreassen, O Spigset
BACKGROUND: The aim of this observational study was to investigate the relationship between metabolic factors and use of selective serotonin reuptake inhibitors (SSRIs) combined with olanzapine, quetiapine or risperidone. METHODS: Data from the Norwegian Thematically Organized Psychosis study, a cross-sectional study on 1301 patients with schizophrenia (n=868) or bipolar disorder (n=433), were analyzed. As exposure variables in the linear regression model were included the dose or serum concentration of SSRIs (n=280) and of olanzapine (n=398), quetiapine (n=234) or risperidone (n=128)...
April 17, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
Benjamin Wildman-Tobriner, Keith J Strauss, Mythreyi Bhargavan-Chatfield, Nadja Kadom, Peter Vock, Kimberly E Applegate, Donald P Frush
OBJECTIVE: Imaging registries afford opportunities to study large, heterogeneous populations. The purpose of this study was to examine the American College of Radiology CT Dose Index Registry (DIR) for dose-related demographics and metrics of common pediatric body CT examinations. MATERIALS AND METHODS: Single-phase CT examinations of the abdomen and pelvis and chest submitted to the DIR over a 5-year period (July 2011-June 2016) were evaluated (head CT frequency was also collected)...
January 11, 2018: AJR. American Journal of Roentgenology
David B Mayfield, Daniel G Skall
The effects characterization phase of ecological risk assessments often includes the selection or development of toxicity reference values (TRVs) for chemicals under investigation. In wildlife risk assessments, TRVs are thresholds represented by a dose or concentration associated with a specified adverse response. Traditionally, a TRV may be derived from an estimate of the no- or lowest adverse effect level (NOAEL or LOAEL), identified from a controlled toxicity study. Due to the limitations in this approach, risk assessors are increasingly developing TRVs using alternative methods...
January 9, 2018: Environmental Toxicology and Chemistry
C Giordano, G Marcello, L Barbattini, R Gobbi
The data analysed came from 545 patients and were related to five types of procedures performed in the urology operating room: percutaneous nephrolithotomy (PCNL), retrograde intrarenal surgery (RIRS), ureteropyeloscopy (UPS), ureteral catheterisation and nephrostomy. Local reference levels (75th percentiles) were determined for the various procedures. The peak entrance skin dose for a patient 20 cm thick was highest for PCNL, being 82 mGy, followed by 43 mGy for nephrostomy, 23 mGy for RIRS, 23 mGy for UPS and 17 mGy for stenting...
January 5, 2018: Radiation Protection Dosimetry
Christina Christia, Giulia Poma, Athanasios Besis, Constantini Samara, Adrian Covaci
Organophosphorus flame retardants (PFRs) and emerging PFRs (ePFRs) are two groups of compounds used as replacements for brominated flame retardants (BFRs). They have already been detected in indoor dust (mainly in homes and offices). To date, few studies investigated the occurrence of FRs in car dust and the information of possible health risks is still limited. The present study reports on the investigation of the levels and profiles of eight target PFRs: tris(2-ethylhexyl) phosphate (TEHP), tris(2-chloroethyl) phosphate (TCEP), tris(2-butoxyethyl) phosphate (TBEP), triphenyl phosphate (TPHP), 2-ethylhexyl diphenyl phosphate (EHDPHP), tris(1-chloro-2-propyl) phosphate (TCIPP), tri cresyl phosphate (TCP), tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and four target ePFRs; 2,2-bis(chloromethyl)propane-1,3-diyltetrakis(2-chloroethyl)bisphosphate (V6), isodecyl diphenyl phosphate (iDDPHP), resorcinol bis(diphenylphosphate) (RDP) and bisphenol A-bis(diphenyl phosphate) (BDP) in car dust from Greece...
December 23, 2017: Chemosphere
Bing-Jun Xiong, Qiu-Wen Tan, Yu-Juan Chen, Yi Zhang, Di Zhang, Shen-Li Tang, Shu Zhang, Qing Lv
BACKGROUND: Adipose-derived stem cell (ADSCs)-assisted and platelet-rich plasma (PRP)-assisted lipofilling aim to enhance angiogenesis and cell proliferation and are promising techniques for lipofilling. This study aimed to compare the outcomes of ADSCs-assisted and PRP-assisted lipofilling. METHODS: Adipose tissue and human venous blood were obtained from women with early breast cancer. Human ADSCs were isolated and amplified in vitro. PRP was extracted through double centrifugation...
January 4, 2018: Aesthetic Plastic Surgery
Daniel Patiño-García, Leonor Cruz-Fernandes, Julio Buñay, Jaime Palomino, Ricardo D Moreno
Endocrine-disrupting chemicals (EDCs) are exogenous compounds that modify hormone biosynthesis, causing adverse effects to human health. Among them, phthalates, and alkylphenols are important due to their wide use in plastics, detergents, personal care products, cosmetics and food packaging. However, their conjoint effects over reproductive female health have not been addressed. The aim of this work was to test the effect of chronically exposed female mice to a mixture of three phthalates [bis (2-ethylhexyl), dibutyl and benzyl butyl] and two alkylphenols [4-nonylphenol and 4-tert-octylphenol], from conception to adulthood at environmentally relevant doses...
December 28, 2017: Endocrinology
Christopher A Barker, Samuel K Kim, Sadna Budhu, Konstantina Matsoukas, Anthony F Daniyan, Sandra P D'Angelo
BACKGROUND: Cytokine release syndrome (CRS) has been reported after immunologic manipulations, most often through therapeutic monoclonal antibodies. To our knowledge, CRS after radiation therapy (RT) for cancer has not been reported before. The development of unusual clinical signs and symptoms after RT led us to investigate the possibility of CRS after RT and review the medical literature on this topic. CASE PRESENTATION: A 65 year-old man with untreated chronic lymphocytic leukemia and recurrent, metastatic Merkel cell carcinoma undergoing anti-programmed death 1 (PD1) immunotherapy was referred for palliative RT to sites of progressing metastases...
January 3, 2018: Journal for Immunotherapy of Cancer
Saleem Ali Banihani
PURPOSE: This review systematically discusses and summarizes the effect of vitamin B6 on semen quality. MATERIAL AND METHOD: To achieve this contribution, we searched the PubMed, Scopus, and Web of Science databases for English language papers from 1984 through 2017 using the key words "sperm" versus "Vitamin B6", "pyridoxine", and "pyridoxal". Also, the references from selected published papers were included, only if relevant. RESULT: To date, as revealed by rodent studies, high doses of vitamin B6 impair semen quality and sperm parameters...
December 30, 2017: Urology Journal
Jonathan Côté, Michèle Bouchard
A toxicokinetic model has been optimized to describe the time profiles of common biomarkers of exposure to permethrin and cypermethrin: trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acids (trans-DCCA) and 3-phenoxybenzoic acid (3-PBA). The model then served to reproduce urinary time courses in exposed agricultural workers and predict corresponding absorbed doses. It allowed for the prediction of the main routes of exposure in workers during the study period. Modeling showed that simulating exposure mostly by the oral route, during the 3-day biomonitoring period, provided best-fits to the urinary time courses of most workers...
December 28, 2017: Journal of Exposure Science & Environmental Epidemiology
Line Underbjerg, Tanja Sikjaer, Lars Rejnmark
Hypoparathyroidism is associated with an increased risk of various complications, but only few data are available on risk factors. Using a case-control design, we assessed associations between biochemical findings and risk of different complications within a subpopulation of our previously identified Danish patients. We retrieved all biochemical data available on 431 (81% women) patients from the Central Region of Denmark, covering approximately 20% of the Danish population. Average age of patients was 41 years at time of diagnosis...
December 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Patrice Roch, David Célier, Cécile Dessaud, Cécile Etard
OBJECTIVES: Twelve years since the implementation of Diagnostic Reference Levels (DRL) process in France, the Nuclear Safety and Radiation Protection French Institute (IRSN) presents its latest analyses performed on the most recent national data. METHODS: Statutorily, each year, medical imaging departments must perform patient exposure evaluation from their clinical practice for at least 2 types of radiographic and computed tomography (CT) examinations freely chosen in the regulatory list...
January 2018: European Journal of Radiology
Leilei Guo, Shangshu Zhang
BACKGROUND: Observational studies evaluating the relationship between ideal cardiovascular health (CVH) metrics and risk of cardiovascular (CV) events and mortality yielded inconsistent results. HYPOTHESIS: Improvement in CVH metrics can result in substantial reductions in the risk of cardiovascular disease (CVD), stroke, and mortality. METHODS: We examined associations between ideal CVH metrics and CV events and mortality by conducting a meta-analysis of data from prospective cohort studies identified by searching PubMed and Web of Science from their inception to February 2017 and reviewing the reference lists of the retrieved articles...
December 26, 2017: Clinical Cardiology
E Jacquelet, J Beretti, A De-Tassigny, N Girardot-Tinant, E Wenisch, A Lachaux, M-C Pheulpin, A Poujois, F Woimant
BACKGROUND: Compliance with treatment is very important for patients who suffer from Wilson's disease, a rare genetic disorder. They can benefit a long-life and effective treatment. The purpose of our study is to identify the level of compliance in Wilson's disease patients and features associated with compliance as well. METHODS: This is a prospective study carried out in the National Reference Center for Wilson Disease (based in Paris and Lyon) over a 8 months period...
December 20, 2017: La Revue de Médecine Interne
Mathieu Charest, Chantal Asselin
Purpose: The aims of the current survey were to draw a portrait of the delivered dose in nuclear medicine selected studies and to assess the degree of changes since an earlier survey performed in 2010. Methods: Each surveyed site had to fill two forms about the administered activity in selected nuclear medicine studies and about the CT parameters used in SPECT/CT imaging, if available. The administered activities were converted into effective doses using the most recent conversion factors. Diagnostic reference levels were computed for each imaging procedure, in order to provide a benchmark for comparison...
December 22, 2017: Journal of Nuclear Medicine Technology
Johannes Boos, Christoph Thomas, Elisabeth Appel, Yan Klosterkemper, Christoph Schleich, Joel Aissa, Oliver Bethge, Gerald Antoch, Patric Kroepil
PURPOSE: To generate size-specific institutional diagnostic reference levels (DRLs) in chest and abdominopelvic computed tomography (CT) based on size-specific dose estimates (SSDE) and depending on patients water-equivalent diameter (Dw). METHODS: 1690 CT examinations were included in the IRB-approved retrospective study. SSDE based on mean water-equivalent diameter of the entire scan volume were calculated automatically. SSDE were analyzed for different patient sizes and institutional DRLs (75% percentiles) based on Dw and SSDE were generated...
December 20, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
Charlotte Remy, Arthur Lalonde, Dominic Béliveau-Nadeau, Jean-Francois Carrier, Hugo Bouchard
{\color{red}The purpose of this study is} to evaluate the impact of a novel tissue characterization method using dual-energy over single-energy computed tomography (DECT and SECT) on Monte Carlo (MC) dose calculations for low-dose rate (LDR) prostate brachytherapy performed in a patient like geometry. A virtual patient geometry is created using contours from a real patient pelvis CT scan, where known elemental compositions and varying densities are overwritten in each voxel. A second phantom is made with additional calcifications...
December 20, 2017: Physics in Medicine and Biology
Taylor Brunton Smith, Justin Solomon, Ehsan Samei
This study's purpose was to develop and validate a method to estimate patient-specific detectability indices directly from patients' CT images (i.e., in vivo). The method extracts noise power spectrum (NPS) and modulation transfer function (MTF) resolution properties from each patient's CT series based on previously validated techniques. These are combined with a reference task function (10-mm disk lesion with [Formula: see text] HU contrast) to estimate detectability indices for a nonprewhitening matched filter observer model...
July 2018: Journal of Medical Imaging
Magda Cepeda, Josje Schoufour, Rosanne Freak-Poli, Chantal M Koolhaas, Klodian Dhana, Wichor M Bramer, Oscar H Franco
BACKGROUND: Controversy exists about the differences in air pollution exposure and inhalation dose between mode of transport. We aimed to review air pollution exposure and inhaled dose according to mode of transport and pollutant and their effect in terms of years of life expectancy (YLE). METHODS: In this systematic review, we searched ten online databases from inception to April 13, 2016, without language or temporal restrictions, for cohort, cross-sectional, and experimental studies that compared exposure to carbon monoxide, black carbon, nitrogen dioxide, and fine and coarse particles in active commuters (pedestrian or cyclist) and commuters using motorised transport (car, motorcycle, bus, or massive motorised transport [MMT-ie, train, subway, or metro])...
January 2017: Lancet. Public Health
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