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Carotid atherosclerosis in chronic kidney disease

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https://www.readbyqxmd.com/read/29728117/diabetic-retinopathy-is-associated-with-the-presence-and-burden-of-subclinical-carotid-atherosclerosis-in-type-1-diabetes
#1
Marc Carbonell, Esmeralda Castelblanco, Xavier Valldeperas, Àngels Betriu, Alícia Traveset, Minerva Granado-Casas, Marta Hernández, Federico Vázquez, Mariona Martín, Esther Rubinat, Albert Lecube, Josep Franch-Nadal, Elvira Fernández, Manel Puig-Domingo, Angelo Avogaro, Núria Alonso, Dídac Mauricio
BACKGROUND: Cardiovascular (CV) disease due to atherosclerosis is a major cause of morbidity and mortality in adult patients with diabetes, either type 1 or type 2 diabetes. The aim of the study was to assess the association of the frequency and the burden of subclinical carotid atherosclerotic disease in patients with type 1 diabetes according to the presence and severity of diabetic retinopathy (DR). METHODS: A cross-sectional study was conducted in 340 patients with type 1 diabetes (41...
May 4, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29519952/association-of-fgf-2-concentrations-with-atheroma-progression-in-chronic-kidney-disease-patients
#2
Milica Bozic, Angels Betriu, Marcelino Bermudez-Lopez, Alberto Ortiz, Elvira Fernandez, Jose M Valdivielso
BACKGROUND AND OBJECTIVES: Atherosclerosis is highly prevalent in CKD. The rate of progression of atherosclerosis is associated with cardiovascular events. Fibroblast growth factor 2 (FGF-2) is a member of the FGF family with potentially both protective and deleterious effects in the development of atherosclerosis. The role of circulating FGF-2 levels in the progression of atherosclerosis in CKD is unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used a multicenter, prospective, observational cohorts study of 481 patients with CKD...
April 6, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29517980/role-of-hypertension-in-progression-of-chronic-kidney-disease-in-children
#3
Smitha R Vidi
PURPOSE OF REVIEW: Hypertension is an independent risk factor for progression of chronic kidney disease (CKD) in children. Children with early CKD develop hypertension secondary to renal disease. This review aims to highlight recent advances that help us better understand the current role of hypertension in progression of CKD in children. RECENT FINDINGS: There is increasing evidence that children with CKD who have hypertension develop early atherosclerosis and cardiac adaptive changes...
April 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29514148/the-relationship-between-carotid-and-femoral-artery-intima-media-thickness-and-histopathologic-grade-of-atherosclerosis-in-patients-with-chronic-kidney-disease
#4
Nariman Nezami, Kamyar Ghabili, Behrooz Shokouhi-Gogani, Mohammad Mirchi, Morteza Ghojazadeh, Javid Safa, Afshar Zomorrodi, Abasad Gharadaghi, Mohammad Khalid Mojadidi, Mohammad Kazem Tarzamni, Ghazal Khajir, Sona Ghorashi, Margarita Revzin
BACKGROUND/AIMS: Variability in the grade of atherosclerosis among patients with chronic kidney disease (CKD) could affect the ultrasound measurements of intima media thickness (IMT). We sought to investigate IMTs of carotid (cIMT) and femoral (fIMT) arteries in CKD patients and assess the degree of their correlation with histopathological atherosclerosis. METHODS: Eighty-nine out of 99 enrolled subjects completed this study. The subjects were divided into 3 groups: 34 patients with CKD (Case group), 31 with coronary artery disease undergoing coronary artery bypass graft (CABG, positive control group), and 24 healthy kidney donors (negative control group)...
March 7, 2018: Nephron
https://www.readbyqxmd.com/read/29512612/the-association-between-serum-hepcidin-25-level-and-subclinical-atherosclerosis-in-peritoneal-dialysis-patients
#5
Bülent Erdoğan, Barış Eser, Özlem Yayar, Mehmet Deniz Aylı
OBJECTIVE: Recently, the role of hepcidin as a cardiovascular marker in the chronic kidney disease (CKD) population has gained interest. The aim of this study was to investigate the relationship between serum hepcidin-25, inflammation, iron parameters, and carotid intima-media thickness (CIMT) in peritoneal dialysis (PD) patients. METHODS: A total of 58 patients (30 male, 51.3%; mean age: 46.8±13.6 years; mean dialysis duration: 69.2±39.1 months) were included in this cross-sectional study...
March 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29488543/association-of-traditional-cardiovascular-risk-factors-with-carotid-atherosclerosis-among-adults-at-a-teaching-hospital-in-south-western-nigeria
#6
Adeleye Dorcas Omisore, Olusola Comfort Famurewa, Morenikeji Adeyoyin Komolafe, Christiana Mopelola Asaleye, Michael Bimbola Fawale, Babalola Ishmael Afolabi
BACKGROUND: Traditional cardiovascular risk factors (CVRFs), which include age, gender, hypertension, diabetes mellitus, dyslipidaemia, smoking, alcohol consumption, chronic kidney disease and obesity, have been shown to be associated with atherosclerosis. We aimed to evaluate the impact of traditional CVRFs on carotid atherosclerosis (CA) in a sample of Nigerian adults. METHODS: We examined 162 subjects with traditional CVRFs in a cross-sectional study. Demographic and clinical data, including history of hypertension, diabetes mellitus, smoking, alcohol intake and chronic kidney disease, as well as systolic and diastolic blood pressure, weight and height were collected...
February 28, 2018: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/29450967/carotid-atherosclerosis-and-the-association-between-nocturnal-blood-pressure-dipping-and-cardiovascular-events
#7
Praew Kotruchin, Satoshi Hoshide, Kazuomi Kario
The impact of a nondipping blood pressure (BP) pattern, defined as (awake systolic BP - sleep systolic BP)/awake systolic BP < 0.1, on cardiovascular events in populations with different degrees of carotid atherosclerosis is uncertain. The authors hypothesized that a nondipping BP pattern would show differential predictive power for cardiovascular events, including total cardiovascular death, sudden death, nonfatal cardiovascular events, and nonfatal stroke, between populations with and without carotid atherosclerosis...
March 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29393214/association-of-circulating-levels-of-adma-with-carotid-intima-media-thickness-in-patients-with-ckd-a-systematic-review-and-meta-analysis
#8
Fang Wang, Ruifang Xiong, Sujuan Feng, Xiangxue Lu, Han Li, Shixiang Wang
BACKGROUND/AIMS: The incidence of cardiovascular disease in patients with chronic kidney disease (CKD) is significantly higher than that in the general population. Carotid intima-media thickness (CIMT) is considered to be an important predictor of atherosclerosis. Asymmetric dimethylarginine (ADMA) acted as an endogenous nitric oxide synthase inhibitor, which was elevated in patients with CKD, but whether plasma ADMA correlate with the CIMT in CKD patients is still not elucidated. METHODS: We searched the PubMed, Cochrane Library and Embase electronic database...
2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29305902/effects-of-oral-paricalcitol-therapy-on-arterial-stiffness-and-osteopontin-in-hypertensive-patients-with-chronic-kidney-disease-and-secondary-hyperparathyroidism
#9
Michalis Giakoumis, Costas Tsioufis, Kyriakos Dimitriadis, Makro Sonikian, Alexandros Kasiakogias, Eirini Andrikou, Theodoros Kalos, Dimitrios Konstantinidis, Konstantinos Filis, Dimitrios Petras, Dimitrios Tousoulis
BACKGROUND: Arterial stiffness is linked to the progression of atherosclerosis, while activation of vitamin D receptor exerts favorable cardiovascular effects in patients with renal insufficiency. In this study, we investigated the effects of oral treatment with paricalcitol, a potent vitamin D receptor activator, on arterial stiffness and osteopontin, a marker of atherosclerosis, in hypertensive patients with chronic kidney disease (CKD) and secondary hyperparathyroidism. METHODS: We followed up 29 treated hypertensive patients (mean age: 74...
January 4, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29248242/plasma-microbiome-modulated-indole-and-phenyl-derived-metabolites-associate-with-advanced-atherosclerosis-and-postoperative-outcomes
#10
Cori A Cason, Kyle T Dolan, Gaurav Sharma, Ming Tao, Rohan Kulkarni, Irene B Helenowski, Brendan M Doane, Michael J Avram, Mary M McDermott, Eugene B Chang, C Keith Ozaki, Karen J Ho
OBJECTIVE: Multiple studies have shown that gut microbes contribute to atherosclerosis, and there is mounting evidence that microbial metabolism of dietary nutrients influences pathophysiology. We hypothesized that indole- and phenyl-derived metabolites that originate solely or in part from bacterial sources would differ between patients with advanced atherosclerosis and age- and sex-matched controls without clinically apparent atherosclerosis. METHODS: Plasma from the advanced atherosclerosis cohort (n = 100) was from patients who underwent carotid endarterectomy, open infrainguinal leg revascularization, or major leg amputation for critical limb ischemia...
December 13, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29205940/relation-of-serum-adma-apelin-13-and-lox-1-levels-with-inflammatory-and-echocardiographic-parameters-in-hemodialysis-patients
#11
Ibrahim Dogan, Tolga Dogan, Mucahit Yetim, Huseyin Kayadibi, Mehmet B Yilmaz, Baris Eser, Macit Kalcik, Yusuf Karavelioglu
Cardiovascular diseases are the leading causes of mortality in patients with chronic kidney disease. Nitric oxide has a critical role in both endothelial dysfunction and the atherosclerosis process. We aimed to investigate the relationships between serum asymmetric dimethyl arginine (ADMA), LOX-1, and Apelin-13 levels, which are known to act over nitric oxide with endothelial dysfunction and cardiac morphology as well as with each other in hemodialysis patients. The study comprised a total of 120 patients (53 females and 67 males) receiving hemodialysis three times a week for at least 6 months and an age-gender matched control group (55 females and 58 males)...
December 4, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29175120/urinary-mirna-377-and-mirna-216a-as-biomarkers-of-nephropathy-and-subclinical-atherosclerotic-risk-in-pediatric-patients-with-type-1-diabetes
#12
Mona Hussein El-Samahy, A A Adly, Yasmine Ibrahim Elhenawy, E A Ismail, Shaimaa Abdelmalik Pessar, Mohamed El-Sayed Mowafy, Mohammed Salah Saad, Hossam Hassan Mohammed
BACKGROUND: Urinary microRNAs (miRNAs) play a role in the pathogenesis of chronic kidney disease (CKD). AIM: To identify the expression of urinary miR-377 and miR-216a in 50 children and adolescents with type 1 diabetes (T1DM) compared with 50 healthy controls and assess their relation to the degree of albuminuria, glycemic control and carotid intimal thickness (CIMT) as an index of atherosclerosis. METHODS: Diabetic subjects were divided into normoalbuminuric and microalbuminuric groups according to urinary albumin creatinine ration (UACR)...
February 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28747676/uremia-does-not-affect-neointima-formation-in-mice
#13
Annemarie Aarup, Carsten H Nielsen, Line S Bisgaard, Ilze Bot, Henrik H El-Ali, Andreas Kjaer, Lars B Nielsen, Tanja X Pedersen
Atherosclerotic cardiovascular disease is a major complication of chronic kidney disease (CKD). CKD leads to uremia, which modulates the phenotype of aortic smooth muscle cells (SMCs). Phenotypic modulation of SMCs plays a key role in accelerating atherosclerosis. We investigated the hypothesis that uremia potentiates neointima formation in response to vascular injury in mice. Carotid wire injury was performed on C57BL/6 wt and apolipoprotein E knockout (Apoe (-/-)) mice two weeks after induction of uremia by 5/6 nephrectomy...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28714271/influence-of-residual-renal-function-in-carotid-modeling-as-a-marker-of-early-atherosclerosis-in-dialysis-patients
#14
Merita Rroji, Nereida Spahia, Saimir Seferi, Myftar Barbullushi, Goce Spasovski
Atherosclerosis is frequently present in patients with chronic kidney disease (CKD) treated with dialysis. We evaluated the association between residual renal function (RRF), phosphate level, inflammation and other risk factors in carotid modeling as a marker of early atherosclerosis in peritoneal dialysis (PD) compared with hemodialysis (HD) patients. We studied 39 stable PD and 53 HD patients on renal replacement therapy (RRT) for 3 to 36 months duration. B-mode ultrasonography was used to determine carotid artery intima media thickness (CIMT)...
October 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28547208/pulse-wave-velocity-and-augmentation-index-are-not-independently-associated-with-carotid-atherosclerosis-in-patients-with-rheumatoid-arthritis
#15
M Robustillo-Villarino, J J Alegre-Sancho, E Rodilla-Sala, A Corrales, J Llorca, M A Gonzalez-Gay, P H Dessein
Arterial stiffness can enhance cardiovascular risk by increasing atherogenesis or adverse hemodynamic effects. We examined whether the arterial stiffness markers of aortic pulse wave velocity (PWV) and the augmentation index (AIx) are independently associated with carotid artery intima-media thickness (IMT) and plaque in patients with rheumatoid arthritis (RA). PWV and AIx were determined by brachial oscillometry using the Mobil-O-Graph® system and carotid IMT and plaque by ultrasound in 194 consecutive RA patients without established cardiovascular disease, chronic kidney disease, and diabetes at disease onset...
November 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28537783/association-of-mild-to-moderate-reduction-in-glomerular-filtration-rate-with-subclinical-atherosclerosis-in-postmenopausal-women
#16
Florina Parv, Andrei Beceanu, Rodica Avram, Romulus Zorin Timar, Bogdan Timar, Florica Gadalean
BACKGROUND: Due to loss of hormonal protective effects, postmenopausal women have an increased cardiovascular (CV) risk. Chronic kidney disease (CKD) is a well-established risk factor for CV disease, but little is known whether mild-to-moderate kidney dysfunction is associated with atherosclerosis burden in the postmenopausal asymptomatic women. MATERIALS AND METHODS: Subclinical atherosclerosis was evaluated in 125 postmenopausal women with no clinical form of atherosclerosis, by carotid and femoral ultrasonography, ankle-brachial index (ABI), and flow-mediated dilation (FMD)...
November 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28483030/value-and-progress-of-ultrasound-in-diagnosis-and-treatment-of-hyperuricemia
#17
Zeyan Gao, Ke Lü
Uric acid is the final end-product of purine metabolism and 70% of it is excreted through the kidneys. Chronic hyperuricemia can easily cause gout and meanwhile may affect the kidneys and cardiovascular system. In recent years,the incidences of hyperuricemia and gout have gradually increased. This article summarizes the correlation of hyperuricemia with hyperuricemic nephropathy,gouty arthritis,non-alcoholic fatty liver disease,and carotid atherosclerosis and the role of color Doppler ultrasound in the diagnosis of these lesions...
April 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28463859/adiponectin-lipids-and-atherosclerosis
#18
REVIEW
Niki Katsiki, Christos Mantzoros, Dimitri P Mikhailidis
PURPOSE OF REVIEW: Adiponectin is an adipokine with anti-inflammatory, antioxidant, antiatherogenic, pro-angiogenic, vasoprotective and insulin-sensitizing properties. Several factors may influence adiponectin levels, such as genetic polymorphisms, obesity / body fat distribution, diet and exercise as well as cardiovascular risk factors such as sleep deprivation and smoking as well as medications. Adiponectin has been proposed as a potential prognostic biomarker and a therapeutic target in patients with cardiometabolic diseases...
August 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#19
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28390291/soluble-tweak-and-atheromatosis-progression-in-patients-with-chronic-kidney-disease
#20
MULTICENTER STUDY
Valvanera Fernández-Laso, Nerea Méndez-Barbero, Jose M Valdivielso, Angels Betriu, Elvira Fernández, Jesús Egido, Jose L Martín-Ventura, Luis M Blanco-Colio
BACKGROUND AND AIMS: Circulating soluble TNF-like weak inducer of apoptosis (sTWEAK) concentrations are related to the presence of chronic kidney disease (CKD) and cardiovascular disease (CVD). However, there are no data regarding the potential association between sTWEAK and atheromatosis progression in patients free of cardiovascular events. METHODS: Soluble TWEAK serum concentration was measured in 702 CKD patients without any previous CV event from The National Observatory of Atherosclerosis in Nephrology (NEFRONA) Study...
May 2017: Atherosclerosis
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