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https://www.readbyqxmd.com/read/28333195/genome-wide-genetic-analyses-highlight-mitogen-activated-protein-kinase-mapk-signaling-in-the-pathogenesis-of-endometriosis
#1
Outi Uimari, Nilufer Rahmioglu, Dale R Nyholt, Katy Vincent, Stacey A Missmer, Christian Becker, Andrew P Morris, Grant W Montgomery, Krina T Zondervan
STUDY QUESTION: Do genome-wide association study (GWAS) data for endometriosis provide insight into novel biological pathways associated with its pathogenesis? SUMMARY ANSWER: GWAS analysis uncovered multiple pathways that are statistically enriched for genetic association signals, analysis of Stage A disease highlighted a novel variant in MAP3K4, while top pathways significantly associated with all endometriosis and Stage A disease included several mitogen-activated protein kinase (MAPK)-related pathways...
February 9, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28325617/human-genetics-and-sleep-behavior
#2
REVIEW
Guangsen Shi, David Wu, Louis J Ptáček, Ying-Hui Fu
Why we sleep remains one of the greatest mysteries in science. In the past few years, great advances have been made to better understand this phenomenon. Human genetics has contributed significantly to this movement, as many features of sleep have been found to be heritable. Discoveries about these genetic variations that affect human sleep will aid us in understanding the underlying mechanism of sleep. Here we summarize recent discoveries about the genetic variations affecting the timing of sleep, duration of sleep and EEG patterns...
March 15, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28325132/physical-symptoms-and-working-performance-in-female-breast-cancer-survivors-a-systematic-review
#3
Kamilla Zomkowski, Bruna Cruz de Souza, Fabiana Pinheiro da Silva, Géssica Maria Moreira, Natália de Souza Cunha, Fabiana Flores Sperandio
PURPOSE: The aim of this systematic review was to summarize and systematize the information about physical symptoms and its relation with work activity on female Breast Cancer Survivors (BCS). METHODS: A systematic search was performed on the databases MEDLINE/PubMed (via National Library of Medicine), SCOPUS (Elsevier), Web of Science (Thomson Reuters Scientific) and CINAHL with full text (EBSCO), including papers about physical impairments experienced by female workers who have had breast cancer...
March 21, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28324948/association-between-visuomotor-adaptation-and-mathematics-skills
#4
M N Anwar, R Rehman, U Hassan
Learning a new motor skill involves multiple cognitive aspects such as attention, planning, prioritizing, execution, and error correction. In current study, we examined whether the students opted for pure mathematics at their undergraduate level have enhanced motor skills as compared to those pursuing biological sciences at the same level of education. A total of twenty subjects participated in a visuomotor adaptation task. The results showed that the overall movement related errors in subjects with mathematics background were lower than the biosciences students (p = 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28321440/neuronify-an-educational-simulator-for-neural-circuits
#5
Svenn-Arne Dragly, Milad Hobbi Mobarhan, Andreas Våvang Solbrå, Simen Tennøe, Anders Hafreager, Anders Malthe-Sørenssen, Marianne Fyhn, Torkel Hafting, Gaute T Einevoll
Educational software (apps) can improve science education by providing an interactive way of learning about complicated topics that are hard to explain with text and static illustrations. However, few educational apps are available for simulation of neural networks. Here, we describe an educational app, Neuronify, allowing the user to easily create and explore neural networks in a plug-and-play simulation environment. The user can pick network elements with adjustable parameters from a menu, i.e., synaptically connected neurons modelled as integrate-and-fire neurons and various stimulators (current sources, spike generators, visual, and touch) and recording devices (voltmeter, spike detector, and loudspeaker)...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28321174/children-s-behavioral-pain-cues-implicit-automaticity-and-control-dimensions-in-observational-measures
#6
Kamal Kaur Sekhon, Samantha R Fashler, Judith Versloot, Spencer Lee, Kenneth D Craig
Some pain behaviors appear to be automatic, reflexive manifestations of pain, whereas others present as voluntarily controlled. This project examined whether this distinction would characterize pain cues used in observational pain measures for children aged 4-12. To develop a comprehensive list of cues, a systematic literature search of studies describing development of children's observational pain assessment tools was conducted using MEDLINE, PsycINFO, and Web of Science. Twenty-one articles satisfied the criteria...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28300515/the-social-before-sociocognitive-theory-explaining-hypnotic-suggestion-in-german-speaking-europe-1900-1960
#7
Anthony D Kauders
The article intends to retrace and review German discourse on hypnotic suggestion from 1900 onward, demonstrating the variety of arguments advanced to account for the social relationship in the hypnotic setting well before the emergence of sociocognitive theory. Using Spanos's distinction between "happenings" and "doings," it shows how, in the case of the "social" in early 20th century German texts on (hypnotic) suggestion, the passive observer, recipient, or victim of hypnosis, a trope familiar to the discipline for many decades, was called into question...
April 2017: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/28299535/the-self-in-movement-being-identified-and-identifying-oneself-in-the-process-of-migration-and-asylum-seeking
#8
Meike Watzlawik, Ignacio Brescó de Luna
How migration influences the processes of identity development has been under longstanding scrutiny in the social sciences. Usually, stage models have been suggested, and different strategies for acculturation (e.g., integration, assimilation, separation, and marginalization) have been considered as ways to make sense of the psychological transformations of migrants as a group. On an individual level, however, identity development is a more complex endeavor: Identity does not just develop by itself, but is constructed as an ongoing process...
March 15, 2017: Integrative Psychological & Behavioral Science
https://www.readbyqxmd.com/read/28291037/tardive-dyskinesia-a-historical-perspective
#9
Matthew Macaluso, Alexandra Flynn, Sheldon H Preskorn
The goal of this column is to provide historical context on tardive dyskinesia (TD) to help the reader understand how the concept was studied and evolved over time. Psychiatrists today should understand this history and consider it in combination with more recent data on the neurobiology of TD, including data from animal studies. This combination of classic data with modern science can help readers develop a more complete understanding and lead to a more judicious use of the term TD, after consideration of all of the alternative causes of abnormal movements, including spontaneous dyskinesia (SD)...
March 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28289265/contact-structure-mobility-environmental-impact-and-behaviour-the-importance-of-social-forces-to-infectious-disease-dynamics-and-disease-ecology
#10
REVIEW
Ronan F Arthur, Emily S Gurley, Henrik Salje, Laura S P Bloomfield, James H Jones
Human factors, including contact structure, movement, impact on the environment and patterns of behaviour, can have significant influence on the emergence of novel infectious diseases and the transmission and amplification of established ones. As anthropogenic climate change alters natural systems and global economic forces drive land-use and land-cover change, it becomes increasingly important to understand both the ecological and social factors that impact infectious disease outcomes for human populations...
May 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28288334/trunk-biomechanics-during-hemiplegic-gait-after-stroke-a-systematic-review
#11
REVIEW
Tamaya Van Criekinge, Wim Saeys, Ann Hallemans, Silke Velghe, Pieter-Jan Viskens, Luc Vereeck, Willem De Hertogh, Steven Truijen
Stroke commonly results in trunk impairments that are associated with decreased trunk coordination and limited trunk muscle strength. These impairments often result in biomechanical changes during walking. Additionally, the so-called pelvic step might be influenced by these impairments. Therefore, the aim of this review was twofold. First, to gain more insight into trunk biomechanics during walking in stroke patients compared to healthy individuals. Second, to investigate the influence of walking speed on trunk biomechanics...
March 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28286474/parameters-and-measures-in-assessment-of-motor-learning-in-neurorehabilitation-a-systematic-review-of-the-literature
#12
REVIEW
Nataliya Shishov, Itshak Melzer, Simona Bar-Haim
Upper limb function, essential for daily life, is often impaired in individuals after stroke and cerebral palsy (CP). For an improved upper limb function, learning should occur, and therefore training with motor learning principles is included in many rehabilitation interventions. Despite accurate measurement being an important aspect for examination and optimization of treatment outcomes, there are no standard algorithms for outcome measures selection. Moreover, the ability of the chosen measures to identify learning is not well established...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28284238/applying-current-concepts-in-pain-related-brain-science-to-dance-rehabilitation
#13
Sarah B Wallwork, Valeria Bellan, G Lorimer Moseley
Dance involves exemplary sensory-motor control, which is subserved by sophisticated neural processing at the spinal cord and brain level. Such neural processing is altered in the presence of nociception and pain, and the adaptations within the central nervous system that are known to occur with persistent nociception or pain have clear implications for movement and, indeed, risk of further injury. Recent rapid advances in our understanding of the brain's representation of the body and the role of cortical representations, or "neurotags," in bodily protection and regulation have given rise to new strategies that are gaining traction in sports medicine...
March 1, 2017: Journal of Dance Medicine & Science
https://www.readbyqxmd.com/read/28275048/brain-machine-interfaces-from-basic-science-to-neuroprostheses-and-neurorehabilitation
#14
REVIEW
Mikhail A Lebedev, Miguel A L Nicolelis
Brain-machine interfaces (BMIs) combine methods, approaches, and concepts derived from neurophysiology, computer science, and engineering in an effort to establish real-time bidirectional links between living brains and artificial actuators. Although theoretical propositions and some proof of concept experiments on directly linking the brains with machines date back to the early 1960s, BMI research only took off in earnest at the end of the 1990s, when this approach became intimately linked to new neurophysiological methods for sampling large-scale brain activity...
April 2017: Physiological Reviews
https://www.readbyqxmd.com/read/28267123/conservative-measures-for-managing-constipation-in-patients-living-with-a-colostomy
#15
Barbara Kuczynska, Adam Bobkiewicz, Adam Studniarek, Krzsztof Szmyt, Łukasz Krokowicz, Konrad Matysiak, Jacek Szmeja, Jarosław Walkowiak, Michał Drews, Tomasz Banasiewicz
PURPOSE: The purpose of this study was to determine the effect of a conservative regimen for the treatment of constipation in persons living with a colostomy. DESIGN: Prospective, noncontrolled, single-center study. SUBJECTS AND SETTING: The study sample comprised 35 patients with a colostomy who were diagnosed with constipation. Subjects with morphologic changes causing constipation such as stomal stenosis and neoplastic and inflammatory changes were excluded...
March 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28254065/biomechzoo-an-open-source-toolbox-for-the-processing-analysis-and-visualization-of-biomechanical-movement-data
#16
Philippe C Dixon, Jonathan J Loh, Yannick Michaud-Paquette, David J Pearsall
It is common for biomechanics data sets to contain numerous dependent variables recorded over time, for many subjects, groups, and/or conditions. These data often require standard sorting, processing, and analysis operations to be performed in order to answer research questions. Visualization of these data is also crucial. This manuscript presents biomechZoo, an open-source toolbox that provides tools and graphical user interfaces to help users achieve these goals. The aims of this manuscript are to (1) introduce the main features of the toolbox, including a virtual three-dimensional environment to animate motion data (Director), a data plotting suite (Ensembler), and functions for the computation of three-dimensional lower-limb joint angles, moments, and power and (2) compare these computations to those of an existing validated system...
March 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28244303/autologous-chondrocyte-implantation-in-the-knee-systematic-review-and-economic-evaluation
#17
Hema Mistry, Martin Connock, Joshua Pink, Deepson Shyangdan, Christine Clar, Pamela Royle, Rachel Court, Leela C Biant, Andrew Metcalfe, Norman Waugh
BACKGROUND: The surfaces of the bones in the knee are covered with articular cartilage, a rubber-like substance that is very smooth, allowing frictionless movement in the joint and acting as a shock absorber. The cells that form the cartilage are called chondrocytes. Natural cartilage is called hyaline cartilage. Articular cartilage has very little capacity for self-repair, so damage may be permanent. Various methods have been used to try to repair cartilage. Autologous chondrocyte implantation (ACI) involves laboratory culture of cartilage-producing cells from the knee and then implanting them into the chondral defect...
February 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28236534/computer-based-algorithmic-determination-of-muscle-movement-onset-using-m-mode-ultrasonography
#18
Andrew J Tweedell, Courtney A Haynes, Matthew S Tenan
The study purpose was to evaluate the use of computer-automated algorithms as a replacement for subjective, visual determination of muscle contraction onset using M-mode ultrasonography. Biceps and quadriceps contraction images were analyzed visually and with three different classes of algorithms: pixel standard deviation (SD), high-pass filter and Teager Kaiser energy operator transformation. Algorithmic parameters and muscle onset threshold criteria were systematically varied within each class of algorithm...
February 21, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28230892/w-e-b-du-bois-at-the-center-from-science-civil-rights-movement-to-black-lives-matter
#19
Aldon Morris
I am honoured to present the 2016 British Journal of Sociology Annual Lecture at the London School of Economics. My lecture is based on ideas derived from my new book, The Scholar Denied: W.E.B. Du Bois and the Birth of Modern Sociology. In this essay I make three arguments. First, W.E.B. Du Bois and his Atlanta School of Sociology pioneered scientific sociology in the United States. Second, Du Bois pioneered a public sociology that creatively combined sociology and activism. Finally, Du Bois pioneered a politically engaged social science relevant for contemporary political struggles including the contemporary Black Lives Matter movement...
February 23, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28229319/a-review-of-the-structure-and-dynamics-of-nanoconfined-water-and-ionic-liquids-via-molecular-dynamics-simulation
#20
REVIEW
Masumeh Foroutan, S Mahmood Fatemi, Farshad Esmaeilian
During the past decade, the research on fluids in nanoconfined geometries has received considerable attention as a consequence of their wide applications in different fields. Several nanoconfined systems such as water and ionic liquids, together with an equally impressive array of nanoconfining media such as carbon nanotube, graphene and graphene oxide have received increasingly growing interest in the past years. Water is the first system that has been reviewed in this article, due to its important role in transport phenomena in environmental sciences...
February 2017: European Physical Journal. E, Soft Matter
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