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Giuseppe Corbo

Daniela Scarabino, Elisabetta Broggio, Giuseppe Gambina, Carlotta Maida, Maria Rosa Gaudio, Rosa Maria Corbo
Mild cognitive impairment (MCI) is the transition stage between the normal aging process and dementia itself. The most common clinical phenotype is amnestic MCI (aMCI) [subtypes: single domain (sMCI) and multiple domains (mMCI)], which is considered prodromal to Alzheimer's disease (AD). The APOE (apolipoprotein E) e4 allele is the most important genetic risk factor for AD, but its association with MCI onset and conversion to AD is controversial. In this follow-up study of 88 aMCI patients (68% sMCI and 32% mMCI at baseline), we examined APOE genotypes and plasma levels in relation to MCI development and progression based on their clinical/cognitive data obtained at baseline and follow-up assessment (mean follow-up time = 6...
September 8, 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Pasquale Russo, Vittorio Capozzi, Giuseppe Spano, Maria R Corbo, Milena Sinigaglia, Antonio Bevilacqua
Safety and quality are significant challenges for food; namely, safety represents a big threat all over the world and is one of the most important goal to be achieved in both Western Society and Developing Countries. Wine safety mainly relies upon some metabolites and many of them are of microbial origin. The main goal of this review is a focus on two kinds of compounds (biogenic amines and mycotoxins, mainly Ochratoxin A) for their deleterious effects on health. For each class of compounds, we will focus on two different traits: (a) synthesis of the compounds in wine, with a brief description of the most important microorganisms and factors leading this phenomenon; (b) prevention and/or correction strategies and new trends...
2016: Frontiers in Microbiology
Daniela Scarabino, Giuseppe Gambina, Elisabetta Broggio, Franca Pelliccia, Rosa Maria Corbo
Family history of dementia (FH) is a recognized risk factor for developing late-onset Alzheimer's disease (AD). We asked whether having FH increases AD risk and influences disease severity (age at onset and cognitive impairment) in 420 AD patients and 109 controls with (FH+) or without (FH-). The relationships of APOE and other AD risk genes with FH were analyzed as well. The proportion of APOE e4 allele carriers was higher among the FH+ than the FH- AD patients (49.6% vs. 38.9%; P = 0.04). The distribution of the risk genotypes of nine AD susceptibility genes previously examined (CHAT, CYP17, CYP19, ESR1, FSHR, P53, P73, P21, PPARG) did not differ between the FH+ and the FH- AD patients, indicating that none contributed significantly to familial clustering of disease...
March 2016: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Nicola Waddell, Marina Pajic, Ann-Marie Patch, David K Chang, Karin S Kassahn, Peter Bailey, Amber L Johns, David Miller, Katia Nones, Kelly Quek, Michael C J Quinn, Alan J Robertson, Muhammad Z H Fadlullah, Tim J C Bruxner, Angelika N Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Craig Nourse, Ehsan Nourbakhsh, Shivangi Wani, Peter J Wilson, Emma Markham, Nicole Cloonan, Matthew J Anderson, J Lynn Fink, Oliver Holmes, Stephen H Kazakoff, Conrad Leonard, Felicity Newell, Barsha Poudel, Sarah Song, Darrin Taylor, Nick Waddell, Scott Wood, Qinying Xu, Jianmin Wu, Mark Pinese, Mark J Cowley, Hong C Lee, Marc D Jones, Adnan M Nagrial, Jeremy Humphris, Lorraine A Chantrill, Venessa Chin, Angela M Steinmann, Amanda Mawson, Emily S Humphrey, Emily K Colvin, Angela Chou, Christopher J Scarlett, Andreia V Pinho, Marc Giry-Laterriere, Ilse Rooman, Jaswinder S Samra, James G Kench, Jessica A Pettitt, Neil D Merrett, Christopher Toon, Krishna Epari, Nam Q Nguyen, Andrew Barbour, Nikolajs Zeps, Nigel B Jamieson, Janet S Graham, Simone P Niclou, Rolf Bjerkvig, Robert Grützmann, Daniela Aust, Ralph H Hruban, Anirban Maitra, Christine A Iacobuzio-Donahue, Christopher L Wolfgang, Richard A Morgan, Rita T Lawlor, Vincenzo Corbo, Claudio Bassi, Massimo Falconi, Giuseppe Zamboni, Giampaolo Tortora, Margaret A Tempero, Anthony J Gill, James R Eshleman, Christian Pilarsky, Aldo Scarpa, Elizabeth A Musgrove, John V Pearson, Andrew V Biankin, Sean M Grimmond
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole-genome sequencing and copy number variation (CNV) analysis of 100 pancreatic ductal adenocarcinomas (PDACs). Chromosomal rearrangements leading to gene disruption were prevalent, affecting genes known to be important in pancreatic cancer (TP53, SMAD4, CDKN2A, ARID1A and ROBO2) and new candidate drivers of pancreatic carcinogenesis (KDM6A and PREX2). Patterns of structural variation (variation in chromosomal structure) classified PDACs into 4 subtypes with potential clinical utility: the subtypes were termed stable, locally rearranged, scattered and unstable...
February 26, 2015: Nature
Giuseppe Lauria, Eleonora Dalla Bella, Giovanni Antonini, Giuseppe Borghero, Margherita Capasso, Claudia Caponnetto, Adriano Chiò, Massimo Corbo, Roberto Eleopra, Raffaella Fazio, Massimiliano Filosto, Fabio Giannini, Enrico Granieri, Vincenzo La Bella, Giancarlo Logroscino, Jessica Mandrioli, Letizia Mazzini, Maria Rosaria Monsurrò, Gabriele Mora, Vladimiro Pietrini, Rocco Quatrale, Romana Rizzi, Fabrizio Salvi, Gabriele Siciliano, Gianni Sorarù, Paolo Volanti, Irene Tramacere, Graziella Filippini
OBJECTIVE: To assess the efficacy of recombinant human erythropoietin (rhEPO) in amyotrophic lateral sclerosis (ALS). METHODS: Patients with probable laboratory-supported, probable or definite ALS were enrolled by 25 Italian centres and randomly assigned (1:1) to receive intravenous rhEPO 40,000 IU or placebo fortnightly as add-on treatment to riluzole 100 mg daily for 12 months. The primary composite outcome was survival, tracheotomy or >23 h non-invasive ventilation (NIV)...
August 2015: Journal of Neurology, Neurosurgery, and Psychiatry
Gino Soldati, Andrea Smargiassi, Riccardo Inchingolo, Sara Sher, Rosanna Nenna, Salvatore Valente, Cosimo Damiano Inchingolo, Giuseppe Maria Corbo
BACKGROUND: Echographic vertical artifacts (B-lines) in chest ultrasonography have often been associated with pathological patterns. A scientifically sound explanation of these artifacts has not yet been proposed. OBJECTIVES: The 'spongy' nature of the lung in its liquid and solid components and the changes that take place in peripheral airspace (PAS) geometry might be the key point to understanding these phenomena. METHODS: Six excised right rabbit lungs were obtained...
2014: Respiration; International Review of Thoracic Diseases
Rosa Maria Corbo, Giuseppe Gambina, Elisabetta Broggio, Daniela Scarabino, Renato Scacchi
The greater predisposition of women to Alzheimer's disease (AD), owing to the decrease in postmenopausal estrogen, may be influenced by polymorphic variation in genes regulating estrogen metabolism (e.g., COMT) and estrogen biosynthesis (e.g., CYP17). In order to better understand how the estrogen pathway genetic variation might affect AD onset, we conducted a case-control study of two single nucleotide polymorphisms (SNPs) of these two genes (COMT rs4680 and CYP17 rs743572) in a sample of AD patients of Italian origin...
September 15, 2014: Journal of the Neurological Sciences
Riccardo Inchingolo, Andrea Smargiassi, Flaminio Mormile, Roberta Marra, Sara De Carolis, Antonio Lanzone, Salvatore Valente, Giuseppe M Corbo
BACKGROUND: This study aimed to evaluate the clinical value of chest ultrasound (US) in the detection, diagnosis and follow-up of pathologic processes of both peripheral lung parenchyma and pleural space in pregnant women. FINDINGS: Pregnant women admitted to Obstetric Pathology Hospital Department for respiratory diseases were enrolled. Chest US examination was performed when there was a respiratory disease highly suggestive of pneumonia and/or pleural effusion and chest X-ray (CXR) should have been obtained...
2014: Multidisciplinary Respiratory Medicine
Michele Simbolo, Matteo Fassan, Andrea Ruzzenente, Andrea Mafficini, Laura D Wood, Vincenzo Corbo, Davide Melisi, Giuseppe Malleo, Caterina Vicentini, Giorgio Malpeli, Davide Antonello, Nicola Sperandio, Paola Capelli, Anna Tomezzoli, Calogero Iacono, Rita T Lawlor, Claudio Bassi, Ralph H Hruban, Alfredo Guglielmi, Giampaolo Tortora, Filippo de Braud, Aldo Scarpa
One-hundred-fifty-three biliary cancers, including 70 intrahepatic cholangiocarcinomas (ICC), 57 extrahepatic cholangiocarcinomas (ECC) and 26 gallbladder carcinomas (GBC) were assessed for mutations in 56 genes using multigene next-generation sequencing. Expression of EGFR and mTOR pathway genes was investigated by immunohistochemistry. At least one mutated gene was observed in 118/153 (77%) cancers. The genes most frequently involved were KRAS (28%), TP53 (18%), ARID1A (12%), IDH1/2 (9%), PBRM1 (9%), BAP1 (7%), and PIK3CA (7%)...
May 15, 2014: Oncotarget
Andrea Smargiassi, Riccardo Inchingolo, Linda Tagliaboschi, Alessandro Di Marco Berardino, Salvatore Valente, Giuseppe Maria Corbo
BACKGROUND: Skeletal muscle weakness with loss of fat-free mass (FFM) is one of the main systemic effects of chronic obstructive pulmonary disease (COPD). The diaphragm is also involved, leading to disadvantageous conditions and poor contractile capacities. OBJECTIVES: We measured the thickness of the diaphragm (TD) by ultrasonography to evaluate the relationships between echographic measurements, parameters of respiratory function and body composition data. METHODS: Thirty-two patients (23 males) underwent (1) pulmonary function tests, (2) echographic assessment of TD in the zone of apposition at various lung volumes, i...
2014: Respiration; International Review of Thoracic Diseases
Katia Nones, Nic Waddell, Sarah Song, Ann-Marie Patch, David Miller, Amber Johns, Jianmin Wu, Karin S Kassahn, David Wood, Peter Bailey, Lynn Fink, Suzanne Manning, Angelika N Christ, Craig Nourse, Stephen Kazakoff, Darrin Taylor, Conrad Leonard, David K Chang, Marc D Jones, Michelle Thomas, Clare Watson, Mark Pinese, Mark Cowley, Ilse Rooman, Marina Pajic, Giovanni Butturini, Anna Malpaga, Vincenzo Corbo, Stefano Crippa, Massimo Falconi, Giuseppe Zamboni, Paola Castelli, Rita T Lawlor, Anthony J Gill, Aldo Scarpa, John V Pearson, Andrew V Biankin, Sean M Grimmond
The importance of epigenetic modifications such as DNA methylation in tumorigenesis is increasingly being appreciated. To define the genome-wide pattern of DNA methylation in pancreatic ductal adenocarcinomas (PDAC), we captured the methylation profiles of 167 untreated resected PDACs and compared them to a panel of 29 adjacent nontransformed pancreata using high-density arrays. A total of 11,634 CpG sites associated with 3,522 genes were significantly differentially methylated (DM) in PDAC and were capable of segregating PDAC from non-malignant pancreas, regardless of tumor cellularity...
September 1, 2014: International Journal of Cancer. Journal International du Cancer
Alessandro Di Marco Berardino, Riccardo Inchingolo, Andrea Smargiassi, Antonina Re, Riccardo Torelli, Barbara Fiori, Tiziana d'Inzeo, Giuseppe Maria Corbo, Salvatore Valente, Maurizio Sanguinetti, Teresa Spanu
Spontaneous chylothorax is rare in adults. We present an unusual case that was complicated by Prevotella bivia empyema. Full recovery was achieved with chest tube drainage and prompt treatment with intravenous clindamycin.
April 2014: Journal of Clinical Microbiology
Renato Scacchi, Giuseppe Gambina, Elisabetta Broggio, Rosa Maria Corbo
BACKGROUND: Many factors could be responsible for the different response to treatment with the cholinesterase inhibitors (ChEIs) donepezil and rivastigmine in Alzheimer's disease (AD) patients. Sex and the variants of the estrogen receptor α (ESR1) gene are reported to modulate AD susceptibility or the course of the disease. The aim of the present study was to verify whether patient's sex and ESR1 genotype could influence the response to ChEI treatment, as there is evidence that estrogens affect cholinergic system functioning...
June 2014: International Journal of Geriatric Psychiatry
Giovanni Leuzzi, Alfredo Cesario, Filippo Lococo, Riccardo Inchingolo, Gianluigi Petrone, Frediano Inzani, Maria Teresa Congedo, Giuseppe Maria Corbo, Salvatore Valente, Pierluigi Granone
No abstract text is available yet for this article.
September 2013: Chest
Silvia Sterzi, Alfredo Cesario, Giacomo Cusumano, Valentina Dall'Armi, Luisa Maria Lapenna, Vittorio Cardaci, Pierluigi Novellis, Filippo Lococo, Giuseppe Maria Corbo, Stefano Cafarotti, Stefano Margaritora, Pierluigi Granone
INTRODUCTION: Post-operative pulmonary rehabilitation in patients who have undergone surgery for lung cancer is a subject of open debate. Clinical practice in this setting is based on the results of observational trials, such as the one described here. Prospective randomized controlled trials have been registered and recruitment is ongoing. METHODS: From 2005 to 2008, 110 patients with surgical non-small cell lung cancer were entered into a post-operative inpatient pulmonary rehabilitation programme for 3 weeks...
September 2013: Journal of Rehabilitation Medicine
Gino Soldati, Andrea Smargiassi, Riccardo Inchingolo, Sara Sher, Salvatore Valente, Giuseppe Maria Corbo
BACKGROUND: The aim of this study is to evaluate feasibility, safety and efficacy of accessing the pleural space with the patient supine or in lateral recumbent position, under constant ultrasonic guidance along the costophrenic sinus. METHODS: All patients with pleural effusion, referred to thoracentesis or pleural drainage from February 2010 to January 2011 in two institutions, were drained either supine or in lateral recumbent position through an echomonitored cannulation of the costophrenic sinus...
2013: Multidisciplinary Respiratory Medicine
Giuseppe Maria Corbo, Riccardo Inchingolo, Gregory Angelo Sgueglia, Gaetano Lanza, Salvatore Valente
Chronic obstructive pulmonary disease (COPD) is associated to cardiovascular morbidity and mortality, and abnormalities of the autonomic nervous system have been described in subjects with severe disease. We studied heart rate variability (HRV) in COPD patients at rest and during the 6-minute Walk Test (6mWT) and the association with lung function impairment taking into account systemic inflammation. Thirty outpatients with stable COPD underwent lung function measurements, blood gas analysis, ECG Holter and transcutaneous pulse oximetry during 6mWT and then they were classified by BODE index...
April 2013: COPD
Mario Sabatelli, Serena Lattante, Amelia Conte, Giuseppe Marangi, Marco Luigetti, Alessandra Del Grande, Adriano Chiò, Massimo Corbo, Fabio Giannini, Jessica Mandrioli, Gabriele Mora, Andrea Calvo, Gabriella Restagno, Christian Lunetta, Silvana Penco, Stefania Battistini, Paolo Zeppilli, Alessandra Bizzarro, Ettore Capoluongo, Giovanni Neri, Paolo Maria Rossini, Marcella Zollino
Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels widely expressed throughout the mammalian brain, including bulbar and spinal motor neurons. They are involved in neuroprotection and in control of release of many neurotransmitters, including glutamate. Previous data raised the hypothesis that rare variants in the region coding the intracellular loop subunits of nAChRs might represent one of several genetic risk factors for SALS. The aim of present study was to replicate the study in an independent cohort of ALS patients...
October 2012: Amyotrophic Lateral Sclerosis
Silvia Sterzi, Alfredo Cesario, Giacomo Cusumano, Giuseppe Corbo, Filippo Lococo, Barbara Biasotti, Luisa Maria Lapenna, Giovanni Magrone, Valentina Dall'armi, Elisa Meacci, Venanzio Porziella, Stefano Bonassi, Stefano Margaritora, Pierluigi Granone
BACKGROUND: The determinants and predictors of QOL in lung cancer survivors who have received surgery remain defined vaguely and still debated. We evaluate clinical, surgical, and pulmonary function characteristics as predictors of QOL in long-term lung cancer survivors who received surgery. METHODS: Quality of life was evaluated 5 years after surgery in 67 lung cancer patients using the European Organization for Research and Treatment of Cancer (EORTC) QOL Core Questionnaire, its lung cancer-specific module QLQ LC-13, and the Hospital Anxiety and Depression Scale questionnaire...
January 2013: Clinical Lung Cancer
Rosa Maria Corbo, Giuseppe Gambina, Renato Scacchi
Studies on human fertility genes have identified numerous risk/protective alleles involved in the occurrence of reproductive system diseases causing infertility or subfertility. Investigations we carried out in populations at natural fertility seem to suggest that the clinical relevance that some fertility genes are now acquiring depends on their interaction with contemporary reproductive behaviors (birth control, delayed childbearing, and spacing birth order, among others). In recent years, a new physiological role in human fertility regulation has emerged for the tumor- suppressor p53 gene (P53), and the P53 Arg72Pro polymorphism has been associated with recurrent implantation failure in humans...
2012: PloS One
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