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Leonarda Galiuto

Giacomo De Luca, Silvia Laura Bosello, Francesca Augusta Gabrielli, Giorgia Berardi, Federico Parisi, Manuela Rucco, Giovanni Canestrari, Francesco Loperfido, Leonarda Galiuto, Filippo Crea, Gianfranco Ferraccioli
BACKGROUND: Arrhythmias are frequent in Systemic Sclerosis (SSc) and portend a bad prognosis, accounting alone for 6% of total deaths. Many of these patients die suddenly, thus prevention and intensified risk-stratification represent unmet medical needs. The major goal of this study was the definition of ECG indexes of poor prognosis. METHODS: We performed a prospective cohort study to define the role of 24h-ECG-Holter as an additional risk-stratification technique in the identification of SSc-patients at high risk of life-threatening arrhythmias and sudden cardiac death (SCD)...
2016: PloS One
Christian Templin, Jelena R Ghadri, Johanna Diekmann, L Christian Napp, Dana R Bataiosu, Milosz Jaguszewski, Victoria L Cammann, Annahita Sarcon, Verena Geyer, Catharina A Neumann, Burkhardt Seifert, Jens Hellermann, Moritz Schwyzer, Katharina Eisenhardt, Josef Jenewein, Jennifer Franke, Hugo A Katus, Christof Burgdorf, Heribert Schunkert, Christian Moeller, Holger Thiele, Johann Bauersachs, Carsten Tschöpe, Heinz-Peter Schultheiss, Charles A Laney, Lawrence Rajan, Guido Michels, Roman Pfister, Christian Ukena, Michael Böhm, Raimund Erbel, Alessandro Cuneo, Karl-Heinz Kuck, Claudius Jacobshagen, Gerd Hasenfuss, Mahir Karakas, Wolfgang Koenig, Wolfgang Rottbauer, Samir M Said, Ruediger C Braun-Dullaeus, Florim Cuculi, Adrian Banning, Thomas A Fischer, Tuija Vasankari, K E Juhani Airaksinen, Marcin Fijalkowski, Andrzej Rynkiewicz, Maciej Pawlak, Grzegorz Opolski, Rafal Dworakowski, Philip MacCarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Filippo Crea, Wolfgang Dichtl, Wolfgang M Franz, Klaus Empen, Stephan B Felix, Clément Delmas, Olivier Lairez, Paul Erne, Jeroen J Bax, Ian Ford, Frank Ruschitzka, Abhiram Prasad, Thomas F Lüscher
BACKGROUND: The natural history, management, and outcome of takotsubo (stress) cardiomyopathy are incompletely understood. METHODS: The International Takotsubo Registry, a consortium of 26 centers in Europe and the United States, was established to investigate clinical features, prognostic predictors, and outcome of takotsubo cardiomyopathy. Patients were compared with age- and sex-matched patients who had an acute coronary syndrome. RESULTS: Of 1750 patients with takotsubo cardiomyopathy, 89...
September 3, 2015: New England Journal of Medicine
Alberto R De Caterina, Antonio Maria Leone, Leonarda Galiuto, Eloisa Basile, Elisa Fedele, Lazzaro Paraggio, Giovanni Luigi De Maria, Italo Porto, Giampaolo Niccoli, Francesco Burzotta, Carlo Trani, Antonio G Rebuzzi, Filippo Crea
OBJECTIVES: To angiographically assess myocardial perfusion in patients with Tako-Tsubo syndrome (TTS) in comparison with control individuals and patients with ST-elevation myocardial infarction (STEMI). BACKGROUND: Coronary microvascular dysfunction has been proposed as the pathophysiological mechanism underlying TTS. METHODS: We retrospectively selected consecutive TTS patients showing typical left ventricular (LV) apical dysfunction admitted to our Department in the period 2007-2011 (n=25)...
October 12, 2013: International Journal of Cardiology
Roxy Senior, Antonella Moreo, Nicola Gaibazzi, Luciano Agati, Klaus Tiemann, Bharati Shivalkar, Stephan von Bardeleben, Leonarda Galiuto, Hervé Lardoux, Giuseppe Trocino, Ignasi Carrió, Dominique Le Guludec, Gianmario Sambuceti, Harald Becher, Paolo Colonna, Folkert Ten Cate, Ezio Bramucci, Ariel Cohen, Gianpaolo Bezante, Costantina Aggeli, Jaroslaw D Kasprzak
OBJECTIVES: The purpose of this study was to compare sulfur hexafluoride microbubble (SonoVue)-enhanced myocardial contrast echocardiography (MCE) with single-photon emission computed tomography (SPECT) relative to coronary angiography (CA) for assessment of coronary artery disease (CAD). BACKGROUND: Small-scale studies have shown that myocardial perfusion assessed by SonoVue-enhanced MCE is a viable alternative to SPECT for CAD assessment. However, large multicenter studies are lacking...
October 8, 2013: Journal of the American College of Cardiology
Leonarda Galiuto, Elisa Fedele, Gabriella Locorotondo, Chiara Pisanello, Carla Favoccia, Maria Ludovica Danza, Elena De Vito, Antonio Giuseppe Rebuzzi, Massimo Massetti, Filippo Crea
No abstract text is available yet for this article.
September 2013: Echocardiography
Leonarda Galiuto, Gabriella Locorotondo, Elisa Fedele, Maria L Danza, Elena De Vito, Ambra Masi, Carla Favoccia, Antonio G Rebuzzi, Filippo Crea
Intra-cardiac thrombi can be incidentally found in recurrent melanoma and need careful assessment. An 81-year-old woman, with a history of malignant nasopharyngeal melanoma, was evaluated by echocardiography and cardiac magnetic resonance due to the detection of undefined masses localized both in right atrium and ventricle during contrast-enhanced thoraco-abdominal computed tomography.
January 2015: Journal of Cardiovascular Medicine
Gaetano A Lanza, Paolo G Camici, Leonarda Galiuto, Giampaolo Niccoli, Carmine Pizzi, Antonio Di Monaco, Alfonso Sestito, Salvatore Novo, Federico Piscione, Isabella Tritto, Giuseppe Ambrosio, Raffaele Bugiardini, Filippo Crea, Mario Marzilli
A growing amount of data is increasingly showing the relevance of coronary microvascular dysfunction (CMVD) in several clinical contexts. This article reviews techniques and clinical investigations of the main noninvasive and invasive methods proposed to study coronary microcirculation and to identify CMVD in the presence of normal coronary arteries, also trying to provide indications for their application in clinical practice.
January 2013: Journal of Cardiovascular Medicine
Leonarda Galiuto, Sabrina Barchetta, Elisa Fedele, Alberto R De Caterina, Gabriella Locorotondo, Antonio M Leone, Francesco Burzotta, Giampaolo Niccoli, Antonio G Rebuzzi, Filippo Crea
AIMS: The effects of the reopening of a coronary total occlusion (CoTO) on microvascular perfusion in subacute or chronic coronary syndromes are actually unclear. We aimed at evaluating the microvascular perfusion pattern by myocardial contrast echocardiography (MCE), in addition to contractile function, before and after CoTO reopening. METHODS: Twenty four patients with subacute and chronic coronary syndromes and CoTO datable >7 days underwent evaluation of microvascular perfusion and left ventricular (LV) function by MCE (Acuson Sequoia, with Sonovue, Bracco) before the reopening of the CoTO and at 9 ± 3 months of follow-up...
May 2013: European Heart Journal Cardiovascular Imaging
Francesco Buccelletti, Leonarda Galiuto, Davide Marsiliani, Paolo Iacomini, Pierpaolo Mattogno, Annarita Carroccia, Chiara Cordischi, Simone Antonini, Elisa Fedele, Marta Sabbatini, Nicolò Gentiloni Silveri, Francesco Franceschi
With the introduction of high sensitivity troponin-T (hs-TnT) assay, clinicians face more patients with 'positive' results but without myocardial infarction. Repeated hs-TnT determinations are warranted to improve specificity. The aim of this study was to compare diagnostic accuracy of three different interpretation rules for two hs-TnT results taken 6 h apart. After adjusting for clinical differences, hs-TnT results were recoded according to the three rules. Rule1: hs-TnT >13 ng/L in at least one determination...
August 2012: Internal and Emergency Medicine
Leonarda Galiuto, Lazzaro Paraggio, Alberto R De Caterina, Elisa Fedele, Gabriella Locorotondo, Lucia Leccisotti, Alessandro Giordano, Antonio G Rebuzzi, Filippo Crea
Several imaging techniques have been used to assess cardiac structure and function, to understand pathophysiology, and to guide clinical decision making in the setting of acute coronary syndromes (ACS). Over the last years, cardiac positron emission tomography (PET) has affirmed its role in this setting. Indeed, the combined quantitative assessment of myocardial metabolism and perfusion has allowed to better understand the functional status of infarcted and non-infarcted myocardium, thus improving our knowledge of myocardial response to necrosis...
February 2012: Journal of Cardiovascular Translational Research
Leonarda Galiuto, Gabriella Locorotondo, Lazzaro Paraggio, Alberto R De Caterina, Antonio M Leone, Elisa Fedele, Sabrina Barchetta, Italo Porto, Luigi Natale, Antonio G Rebuzzi, Lorenzo Bonomo, Filippo Crea
AIMS: The anatomical correlates of perfusion defect (PD) at myocardial contrast echocardiography (MCE) in the subacute phase of ST-elevation myocardial infarction (STEMI) are currently unknown. The study aimed at assessing whether, in the subacute phase of STEMI, within MCE PD microvessels are anatomically damaged or if some vasodilation can be still elicited and if the PD correlates with the extent of myocardial necrosis. METHODS AND RESULTS: Twenty-two post-percutaneous coronary intervention (PCI) patients underwent MCE 7 ± 1 days after STEMI, at baseline and after adenosine (ADN) administration...
February 2012: European Heart Journal Cardiovascular Imaging
Alberto Ranieri De Caterina, Leonarda Galiuto, Elisa Fedele, Filippo Crea
The term "coronary instability" commonly refers to the sequence of events that lead from plaque erosion or rupture to the occurrence of acute coronary syndromes (ACS). However, evidence indicates that coronary microvascular dysfunction plays a relevant pathophysiologic and prognostic role in the setting of ACS, both in ST-segment elevation myocardial infarction and in non-ST-segment elevation ACS. Our group have recently demonstrated that Tako-Tsubo syndrome, which clinically mimics ACS, is sustained by a common pathophysiologic mechanism represented by reversible coronary microvascular dysfunction...
November 15, 2011: American Journal of Cardiology
Italo Porto, Christian Hamilton-Craig, Giovanni Luigi De Maria, Rocco Vergallo, Giorgio Cautilli, Leonarda Galiuto, Francesco Burzotta, Antonio Maria Leone, Giampaolo Niccoli, Luigi Natale, Lorenzo Bonomo, Filippo Crea
BACKGROUND: After ST-elevation myocardial infarction (STEMI), microvascular obstruction (MVO) can be assessed using semiquantitative angiographic "blush" scores subject to interoperator variability. Quantitative Blush Evaluator (QuBE) is a free computer-calculated algorithm that evaluates myocardial blush on a continuous scale with improved reproducibility. We aimed to compare QuBE with cardiovascular magnetic resonance (CMR) in detecting MVO and its severity. METHODS: Fifty-two STEMI treated with successful primary percutaneous coronary intervention were enrolled...
August 2011: American Heart Journal
Leonarda Galiuto, Simona Giubilato, Alberto R De Caterina, Angelo Porfidia, Christian Colizzi, Alfonso Sestito, Italo Porto, Carlo Trani, Antonio G Rebuzzi, Filippo Crea
Patent foramen ovale (PFO) is a known cause of cryptogenic stroke and, when associated with a condition of thrombophilia, its closure has been shown to reduce the recurrence of cerebral embolic events. Here we present a case of a young man, with a history of previous recurrent cerebral ischaemic episodes, that developed an inferior acute myocardial infarction (AMI) with angiographic evidence of thrombotic occlusion of the right coronary artery (RCA). Thrombus aspiration followed by balloon angioplasty was performed and, after 24 h of glycoprotein IIb/IIIa inhibitor infusion, thrombus was no longer evident at coronary angiography...
2009: BMJ Case Reports
Christian R Hamilton-Craig, Italo Porto, Giovanni-Luigi de Maria, Luigi Natale, Leonarda Galiuto, Filippo Crea
No abstract text is available yet for this article.
April 2011: Heart, Lung & Circulation
Stefania Funaro, Leonarda Galiuto, Francesca Boccalini, Sara Cimino, Emanuele Canali, Francesca Evangelio, Laura DeLuca, Lazzaro Paraggio, Antonella Mattatelli, Lucio Gnessi, Luciano Agati
AIMS: Microvascular damage (MD) occurring soon after primary percutaneous coronary intervention (PPCI) may reverse or remain sustained within the first week after ST-elevation myocardial infarction (STEMI). We investigated the incidence, determinants, and long-term clinical relevance of MD reversal after PPCI. METHODS AND RESULTS: Serial two-dimensional echocardiograms (2DE) and a myocardial contrast study were obtained within 24 h of PPCI (T1) and at pre-discharge (T2) in 110 successfully re-perfused STEMI patients...
April 2011: European Journal of Echocardiography
Italo Porto, Christian Hamilton-Craig, Marta Brancati, Francesco Burzotta, Leonarda Galiuto, Filippo Crea
Assessment of myocardial "blush" by either Myocardial Blush Grade or TIMI Myocardial Perfusion Grade, is the angiographic method currently preferred to confirm myocardial tissue-level perfusion after primary percutaneous intervention. This review focuses on the utility of angiographic "blush" as a simple, widely available, and virtually costless technique for the immediate diagnosis of microvascular impairment at the time of acute catheterization. We comprehensively outline the available evidence behind the "blush," its use in clinical practice, and draw comparisons with other new technologies for assessment of microvascular integrity...
December 2010: American Heart Journal
Leonarda Galiuto, Francesca A Gabrielli, Gaetano A Lanza, Angelo Porfidia, Lazzaro Paraggio, Sabrina Barchetta, Gabriella Locorotondo, Alberto R De Caterina, Antonio G Rebuzzi, Filippo Crea
AIMS: To ascertain whether the presence of left ventricular (LV) hypertrophy in patients with ST-segment elevation myocardial infarction (STEMI) influences microvascular dysfunction and LV remodelling at 6 months of follow-up. METHODS AND RESULTS: Fifty-six consecutive STEMI patients successfully treated with primary or rescue percutaneous coronary intervention underwent conventional two-dimensional and myocardial contrast echocardiography within 24 h and at 6 months...
September 2010: European Journal of Echocardiography
Leonarda Galiuto, Alberto Ranieri De Caterina, Angelo Porfidia, Lazzaro Paraggio, Sabrina Barchetta, Gabriella Locorotondo, Antonio Giuseppe Rebuzzi, Filippo Crea
AIMS: To study coronary microvascular dysfunction as possible pathogenetic mechanism in Apical Ballooning Syndrome (ABS). METHODS AND RESULTS: Fifteen ABS patients (all women, 68 +/- 14 years) underwent myocardial contrast echocardiography at baseline during adenosine infusion (140 microg/kg/min) and at 1-month follow-up and compared with a group of anterior ST-elevation myocardial infarction (STEMI) patients with similar clinical characteristics. Myocardial perfusion was assessed by contrast score index (CSI) and endocardial length of contrast defect (contrast defect length, CDL), whereas myocardial dysfunction by wall motion score index (WMSI), endocardial length of contractile dysfunction (wall motion defect length, WMDL), and LV ejection fraction (LVEF)...
June 2010: European Heart Journal
Giampaolo Niccoli, Francesco Burzotta, Leonarda Galiuto, Filippo Crea
In a variable proportion of patients presenting with ST-segment elevation myocardial infarction, ranging from 5% to 50%, primary percutaneous coronary intervention achieves epicardial coronary artery reperfusion but not myocardial reperfusion, a condition known as no-reflow. Of note, no-reflow is associated with a worse prognosis at follow-up. The phenomenon has a multifactorial pathogenesis including: distal embolization, ischemia-reperfusion injury, and individual predisposition of coronary microcirculation to injury...
July 21, 2009: Journal of the American College of Cardiology
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