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https://www.readbyqxmd.com/read/28254182/herbal-medications-in-cardiovascular%C3%A2-medicine
#1
REVIEW
Rosa Liperoti, Davide L Vetrano, Roberto Bernabei, Graziano Onder
Herbal medications are commonly used for clinical purposes, including the treatment of cardiovascular conditions. Compared with conventional medications, herbal medications do not require clinical studies before their marketing or formal approval from regulatory agencies, and for this reason their efficacy and safety are rarely proven. In this review, we summarize available evidence on herbal medications mostly used in cardiovascular medicine. We show that the use of these medications for the treatment of cardiovascular diseases is often not supported by scientific evidence...
March 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28238677/improving-public-awareness-of-multimorbidity
#2
EDITORIAL
Alessandra Marengoni, Laura Fratiglioni, Graziano Onder
No abstract text is available yet for this article.
May 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28129493/antipsychotic-drug-interactions-and-mortality-among-nursing-home-residents-with-cognitive-impairment
#3
Rosa Liperoti, Federica Sganga, Francesco Landi, Eva Topinkova, Michael D Denkinger, Henriëtte G van der Roest, Andrea D Foebel, Harriet Finne-Soveri, Roberto Bernabei, Graziano Onder
OBJECTIVE: Among elderly individuals with dementia, the use of antipsychotics has been associated with serious adverse events including ischemic stroke and death. Multiple medications can interact with antipsychotics and increase the risk of such adverse events. The purpose of this retrospective, longitudinal cohort study was to estimate the prevalence of potential antipsychotic drug interactions and their effect on increasing the risk of death among cognitively impaired elderly individuals treated with antipsychotics...
January 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28126135/prevention-of-functional-decline-by-reframing-the-role-of-nursing-homes
#4
Clarisse Laffon de Mazières, John E Morley, Cari Levy, Fabien Agenes, Mario Barbagallo, Matteo Cesari, Philipe De Souto Barreto, Lorenzo Maria Donini, Jaime Fitten, Alain Franco, Mikel Izquierdo, Rosalie A Kane, Finbarr C Martin, Graziano Onder, Joseph Ouslander, Kaisu Pitkälä, Debra Saliba, Alan Sinclair, Leocadio Rodriguez Manas, Bruno Vellas, Yves Rolland
Institutionalization is generally a consequence of functional decline driven by physical limitations, cognitive impairments, and/or loss of social supports. At this stage, intervention to reverse functional losses is often too late. To be more effective, geriatric medicine must evolve to intervene at an earlier stage of the disability process. Could nursing homes (NHs) transform from settings in which many residents dwell to settings in which the NH residents and those living in neighboring communities benefit from staff expertise to enhance quality of life and maintain or slow functional decline? A task force of clinical researchers met in Toulouse on December 2, 2015, to address some of these challenges: how to prevent or slow functional decline and disabilities for NH residents and how NHs may promote the prevention of functional decline in community-dwelling frail elderly...
February 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28111156/defining-a-care-pathway-for-patients-with-multimorbidity-or-frailty
#5
EDITORIAL
Graziano Onder, Matteo Cesari, Marcello Maggio, Katie Palmer
No abstract text is available yet for this article.
January 19, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28003375/assessing-and-measuring-chronic-multimorbidity-in-the-older-population-a-proposal-for-its-operationalization
#6
Amaia Calderón-Larrañaga, Davide L Vetrano, Graziano Onder, Luis A Gimeno-Feliu, Carlos Coscollar-Santaliestra, Angelo Carfí, Maria S Pisciotta, Sara Angleman, René J F Melis, Giola Santoni, Francesca Mangialasche, Debora Rizzuto, Anna-Karin Welmer, Roberto Bernabei, Alexandra Prados-Torres, Alessandra Marengoni, Laura Fratiglioni
BACKGROUND: Although the definition of multimorbidity as "the simultaneous presence of two or more chronic diseases" is well established, its operationalization is not yet agreed. This study aims to provide a clinically driven comprehensive list of chronic conditions to be included when measuring multimorbidity. METHODS: Based on a consensus definition of chronic disease, all four-digit level codes from the International Classification of Diseases, 10th revision (ICD-10) were classified as chronic or not by an international and multidisciplinary team...
December 21, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28000156/predicting-the-risk-of-adverse-drug-reactions-in-older-inpatients-external-validation-of-the-gerontonet-adr-risk-score-using-the-crime-cohort
#7
Mirko Petrovic, Balamurugan Tangiisuran, Chakravarthi Rajkumar, Tischa van der Cammen, Graziano Onder
BACKGROUND: Adverse drug reactions (ADRs) in older people are often preventable, indicating that screening and prevention programs aimed at reducing their rate are needed in this population. OBJECTIVE: The aim of this study was to externally validate the GerontoNet ADR risk score and to assess its validity in specific subpopulations of older inpatients. METHODS: Data from the prospective CRIteria to assess appropriate Medication use among Elderly complex patients (CRIME) cohort were used...
December 20, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27868320/predictors-of-rehospitalization-among-older-adults-results-of-the-crime-study
#8
Federica Sganga, Francesco Landi, Stefano Volpato, Antonio Cherubini, Carmelinda Ruggiero, Andrea Corsonello, Paolo Fabbietti, Fabrizia Lattanzio, Ester Manes Gravina, Roberto Bernabei, Graziano Onder
AIM: To assess the predictors of readmission among older adults hospitalized in acute care wards. METHODS: A prospective cohort study was carried out among 921 hospitalized older adults participating in the CRiteria to Assess Appropriate Medication Use among Elderly Complex Patients (CRIME) project. The primary outcome of the study was rehospitalization within 1 year after discharge from acute care hospitals. We assessed the participants with a questionnaire including 350 items about demographic, social and clinical characteristics...
November 21, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27862784/does-being-assisted-by-care-workers-affect-antipsychotics-prescription-among-older-people-discharged-from-hospital
#9
Mirko Di Rosa, Paolo Fabbietti, Andrea Corsonello, Sergio Fusco, Federica Sganga, Stefano Volpato, Carmelinda Ruggiero, Graziano Onder, Fabrizia Lattanzio
AIM: Several factors can affect antipsychotic prescriptions, among which, caregivers. However, whether being assisted by a care worker might increase the rate of antipsychotic prescriptions at discharge from acute care hospital has not been previously investigated. We aimed to investigate whether being assisted by a care worker is associated with increased use of antipsychotics among older patients discharged from acute care hospitals. METHODS: The present series consisted of 928 patients not taking antipsychotics at admission in seven acute care wards of geriatric medicine in Italy (mean age 80...
November 10, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27813416/social-and-functional-health-of-home-care-clients-with-different-levels-of-cognitive-impairments
#10
Vjenka Garms-Homolová, Nanna Notthoff, Anja Declercq, Henriette G van der Roest, Graziano Onder, Pálmi Jónsson, Hein van Hout
OBJECTIVES: The ability to manage one's life with some degree of independence, to fulfill basic obligations, and to participate in social activities are social functions that delineate the core of 'social health'. We examine to what extent clients of community care in Europe (n = 2884) complete such activities despite their cognitive problems. We focus on mildly and moderately impaired people, aged 65+ years. METHODS: Data were collected using the interRAI HC-Assessment in IBenC-project...
January 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/27804276/impact-of-disease-duration-and-cardiovascular-dysautonomia-on-hypertension-in-parkinson-s-disease
#11
Davide L Vetrano, Maria S Pisciotta, Vincenzo Brandi, Maria R Lo Monaco, Alice Laudisio, Graziano Onder, Domenico Fusco, Paolo D L'Angiocola, Anna R Bentivoglio, Roberto Bernabei, Giuseppe Zuccalà
The authors evaluated the association of Parkinson's disease (PD) duration with hypertension, assessed by office measurements and 24-hour (ambulatory) monitoring, in 167 patients. Hypertension was evaluated through both office and ambulatory blood pressure (BP) measurements. Among participants (mean age 73.4±7.6 years; 35% women), the prevalence of hypertension was 60% and 69% according to office and ambulatory BP measurements, respectively (Cohen's k=0.61; P<.001). PD duration was inversely associated with hypertension as diagnosed by office measurements (odds ratio [OR], 0...
November 2, 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/27590402/anticholinergic-medication-burden-and-5-year-risk-of-hospitalization-and-death-in-nursing-home-elderly-residents-with-coronary-artery-disease
#12
Davide L Vetrano, Domenico La Carpia, Giulia Grande, Paola Casucci, Tiziana Bacelli, Roberto Bernabei, Graziano Onder
OBJECTIVES: To assess the association of the anticholinergic medication burden with hospitalization and mortality in nursing home elderly patients and to investigate the role of coronary artery disease (CAD). DESIGN: Longitudinal (5-year) retrospective observational study. SETTING: Nursing homes in Italy. PARTICIPANTS: A total of 3761 nursing home older residents. MEASUREMENTS: A comprehensive clinical and functional assessment was carried out through the interRAI long-term care facility instrument...
August 30, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27561315/convergent-validity-of-the-interrai-hc-for-societal-costs-estimates-in-comparison-with-the-rud-lite-instrument-in-community-dwelling-older-adults
#13
Lisanne I van Lier, Henriëtte G van der Roest, Hein P J van Hout, Liza van Eenoo, Anja Declercq, Vjenka Garms-Homolová, Graziano Onder, Harriet Finne-Soveri, Pálmi V Jónsson, Cees M P M Hertogh, Judith E Bosmans
BACKGROUND: The interRAI-Home Care (interRAI-HC) instrument is commonly used in routine care to assess care and service needs, resource utilisation and health outcomes of community dwelling home care clients. Potentially, the interRAI-HC can also be used to calculate societal costs in economic evaluations. The purpose of this study was to assess the convergent validity of the interRAI-HC instrument in comparison with the RUD Lite instrument for the calculation of societal costs among care-dependent community dwelling older adults...
2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27456324/impact-of-physical-function-impairment-and-multimorbidity-on-mortality-among-community-living-older-persons-with-sarcopaenia-results-from-the-ilsirente-prospective-cohort-study
#14
Francesco Landi, Riccardo Calvani, Matteo Tosato, Anna Maria Martone, Roberto Bernabei, Graziano Onder, Emanuele Marzetti
OBJECTIVE: Sarcopaenia and physical function impairment may have a greater effect on survival than other clinical characteristics, including multimorbidity. In this study, we evaluated the impact of sarcopaenia on all-cause mortality and the interaction among muscle loss, physical function impairment and multimorbidity on mortality risk over 10 years in older community-dwellers. DESIGN: Prospective cohort study. SETTING: Population-based study...
2016: BMJ Open
https://www.readbyqxmd.com/read/27444182/strategies-to-improve-medication-adherence-in-older-persons-consensus-statement-from-the-senior-italia-federanziani-advisory-board
#15
Alessandra Marengoni, Alessandro Monaco, Elisio Costa, Antonio Cherubini, Alexandra Prados-Torres, Christiane Muth, Renè J F Melis, Luca Pasina, Tischa J M van der Cammen, Katie Palmer, Sergio Pecorelli, Graziano Onder
Poor adherence to treatment regimens has long been recognized as a substantial roadblock to achieving better outcomes for patients. Non-adherence to medications affects the quality and length of life and has been associated with negative health outcomes and increasing healthcare costs. The problem of non-adherence is particularly troublesome in older patients who are affected by multiple chronic diseases and for this reason receive multiple treatments. To date, no single intervention strategy has been shown to be effective in improving adherence across all patients, conditions, and settings...
September 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27342004/delivery-of-care-to-nursing-home-residents-with-diabetes-results-from-the-shelter-study
#16
Katarzyna Szczerbińska, Eva Topinková, Piotr Brzyski, Henriette G van der Roest, Tomáš Richter, Harriet Finne-Soveri, Michael D Denkinger, Jacob Gindin, Graziano Onder, Roberto Bernabei
OBJECTIVES: To describe health care and preventive service provision to nursing home (NH) residents with diabetes mellitus (DM) and to analyze factors determining use of selected services. DESIGN: In the period between 2009 and 2011, the Services and Health for Elderly in Long TERm care (SHELTER) project, a 12-month prospective cohort study, was conducted to assess 4037 NH residents aged 60 years and older residing in 59 NHs in 7 European countries and Israel. METHODS: The InterRAI tool for long-term care facilities was used to assess care needs and provided health care services...
September 1, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27317470/defining-patient-centric-pharmaceutical-drug-product-design
#17
REVIEW
Sven Stegemann, Robert L Ternik, Graziano Onder, Mansoor A Khan, Diana A van Riet-Nales
The term "patient centered," "patient centric," or "patient centricity" is increasingly used in the scientific literature in a wide variety of contexts. Generally, patient centric medicines are recognized as an essential contributor to healthy aging and the overall patient's quality of life and life expectancy. Besides the selection of the appropriate type of drug substance and strength for a particular indication in a particular patient, due attention must be paid that the pharmaceutical drug product design is also adequately addressing the particular patient's needs, i...
2016: AAPS Journal
https://www.readbyqxmd.com/read/27114104/effectiveness-of-comprehensive-care-programs-for-patients-with-multiple-chronic-conditions-or-frailty-a-systematic-literature-review
#18
REVIEW
Petra Hopman, Simone R de Bruin, Maria João Forjaz, Carmen Rodriguez-Blazquez, Giuseppe Tonnara, Lidwien C Lemmens, Graziano Onder, Caroline A Baan, Mieke Rijken
OBJECTIVE: To describe comprehensive care programs targeting multimorbid and/or frail patients and to estimate their effectiveness regarding improvement of patient and caregiver related outcomes, healthcare utilization and costs. METHODS: Systematic search in six electronic databases for scientific papers published between January 2011 and March 2014, supplemented by reference tracking. Wagner's Chronic Care Model (CCM) was used to operationalize comprehensive care...
July 2016: Health Policy
https://www.readbyqxmd.com/read/27114077/inappropriate-prescription-of-low-molecular-weight-heparins-for-thromboprophylaxis-among-older-hospitalized-patients
#19
Sabrina Garasto, Sergio Fusco, Graziano Onder, Federica Sganga, Federica Mammarella, Stefano Volpato, Carmelinda Ruggiero, Angela M Abbatecola, Fabrizia Lattanzio, Andrea Corsonello
AIM: To investigate the prevalence and clinical correlates of overprescribing and underprescribing of low molecular weight heparins (LMWHs) for thromboprophylaxis among older medical inpatients. METHODS: Eight hundred seventy six patients (mean age 81.5 ± 7.6 years, female gender 57.2 %) enrolled in a multicenter observational study of seven acute care wards of geriatric medicine in Italy. The risk of venous thromboembolism was ascertained by calculating the Padua score for each patient...
April 25, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27067615/frailty-the-pleasure-and-pain-of-geriatric-medicine
#20
EDITORIAL
Graziano Onder, Alessandra Marengoni
No abstract text is available yet for this article.
June 2016: European Journal of Internal Medicine
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