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https://www.readbyqxmd.com/read/29114834/polypharmacy
#1
Graziano Onder, Alessandra Marengoni
No abstract text is available yet for this article.
November 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29069321/influenza-and-pneumococcal-vaccination-in-older-adults-living-in-nursing-home-a-survival-analysis-on-the-shelter-study
#2
Andrea Poscia, Agnese Collamati, Angelo Carfì, Eva Topinkova, Tomas Richter, Michael Denkinger, Roberta Pastorino, Francesco Landi, Walter Ricciardi, Roberto Bernabei, Graziano Onder
Background: Influenza and pneumococcal vaccines have been proved to be effective and safe in preventing and controlling infection among elderly, reducing morbidity and mortality. However, some evidences raised health concerns related to these vaccinations. This study aims to identify prevalence and outcomes related to influenza and pneumococcal vaccinations in a large European population of frail old people living in nursing homes (NHs). Methods: We conducted a survival analysis of NH residents participating to the Services and Health for Elderly in Long-TERm project, a prospective cohort study collecting information on residents admitted to 57 NH in eight countries (Czech Republic, England, Finland, France, Germany, Italy, The Netherlands and Israel)...
October 23, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29032349/organizational-home-care-models-across-europe-a-cross-sectional-study
#3
Liza Van Eenoo, Henriëtte van der Roest, Graziano Onder, Harriet Finne-Soveri, Vjenka Garms-Homolova, Palmi V Jonsson, Stasja Draisma, Hein van Hout, Anja Declercq
BACKGROUND: Decision makers are searching for models to redesign home care and to organize health care in a more sustainable way. OBJECTIVES: The aim of this study is to identify and characterize home care models within and across European countries by means of structural characteristics and care processes at the policy and the organization level. DATA SOURCES: At the policy level, variables that reflected variation in health care policy were included based on a literature review on the home care policy for older persons in six European countries: Belgium, Finland, Germany, Iceland, Italy, and the Netherlands...
September 21, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28975522/calcium-channel-blockers-in-secondary-cardiovascular-prevention-and-risk-of-acute-events-real-world-evidence-from-nested-case-control-studies-on-italian-hypertensive-elderly
#4
Alessandra Bettiol, Ersilia Lucenteforte, Alfredo Vannacci, Niccolò Lombardi, Graziano Onder, Nera Agabiti, Cristiana Vitale, Gianluca Trifirò, Giovanni Corrao, Giuseppe Roberto, Alessandro Mugelli, Alessandro Chinellato
BACKGROUND AND OBJECTIVES: Antihypertensive treatment with calcium channel blockers (CCBs) is consolidated in clinical practice; however, different studies observed increased risks of acute events for short-acting CCBs. This study aimed to provide real-world evidence on risks of acute cardiovascular (CV) events, hospitalizations and mortality among users of different CCB classes in secondary CV prevention. METHODS: Three case-control studies were nested in a cohort of Italian elderly hypertensive CV-compromised CCBs users...
October 3, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28967492/multimorbidity-care-model-recommendations-from-the-consensus-meeting-of-the-joint-action-on-chronic-diseases-and-promoting-healthy-ageing-across-the-life-cycle-ja-chrodis
#5
Katie Palmer, Alessandra Marengoni, Maria João Forjaz, Elena Jureviciene, Tiina Laatikainen, Federica Mammarella, Christiane Muth, Rokas Navickas, Alexandra Prados-Torres, Mieke Rijken, Ulrike Rothe, Laurène Souchet, Jose Valderas, Theodore Vontetsianos, Jelka Zaletel, Graziano Onder
Patients with multimorbidity have complex health needs but, due to the current traditional disease-oriented approach, they face a highly fragmented form of care that leads to inefficient, ineffective, and possibly harmful clinical interventions. There is limited evidence on available integrated and multidimensional care pathways for multimorbid patients. An expert consensus meeting was held to develop a framework for care of multimorbid patients that can be applied across Europe, within a project funded by the European Union; the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS)...
September 14, 2017: Health Policy
https://www.readbyqxmd.com/read/28957993/an-international-perspective-on-chronic-multimorbidity-approaching-the-elephant-in-the-room
#6
Davide L Vetrano, Amaia Calderón-Larrañaga, Alessandra Marengoni, Graziano Onder, Jürgen M Bauer, Matteo Cesari, Luigi Ferrucci, Laura Fratiglioni
Multimorbidity is a common and burdensome condition that may affect quality of life, increase medical needs and make people live more years of life with disability. Negative outcomes related to multimorbidity occur beyond what we would expect from the summed effect of single conditions, as chronic diseases interact with each other, mutually enhancing their negative effects, and eventually leading to new clinical phenotypes. Moreover, multimorbidity mirrors an accelerated global susceptibility and a loss of resilience, which are both hallmarks of aging...
September 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28870834/prevalence-of-preventive-cardiovascular-medication-use-in-nursing-home-residents-room-for-deprescribing-the-shelter-study
#7
Alireza Malek Makan, Hein van Hout, Graziano Onder, Harriet Finne-Soveri, Henriëtte van der Roest, Rob van Marum
INTRODUCTION: In nursing home (NH) residents with a very short life expectancy, the benefits of preventive cardiovascular medication maintenance are questionable. OBJECTIVE: To assess the prevalence of 4 classes of preventive cardiovascular medication (PCM) in NH residents, and to explore differences of prevalence across length of stay, mortality risk, cognitive impairment, functional disability, and across countries. METHODS: A 12-month prospective cohort study was conducted in 57 NHs in 8 countries (Czech Republic, England, Finland, France, Germany, Italy, The Netherlands, and Israel)...
September 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28766100/anticholinergic-burden-and-health-outcomes-among-older-adults-discharged-from-hospital-results-from-the-crime-study
#8
Marta Gutiérrez-Valencia, Nicolás Martínez-Velilla, Davide Liborio Vetrano, Andrea Corsonello, Fabrizia Lattanzio, Sergio Ladrón-Arana, Graziano Onder
PURPOSE: The purpose of this study is to investigate whether there is an association between anticholinergic burden and mortality or rehospitalization in older adults discharged from hospital. METHODS: Prospective multicenter cohort study carried out with patients aged 65 and older discharged from seven acute care hospitals. The primary outcomes of the study were rehospitalization and mortality within 1 year after discharge. The study population was classified in three groups according to the anticholinergic exposure measured by the Anticholinergic Risk Scale (ARS) and Durán's list at the time of hospital discharge: without risk (ARS/Durán = 0), low risk (ARS/Durán = 1), and high risk (ARS/Durán ≥ 2)...
November 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28656664/poor-adherence-to-chronic-obstructive-pulmonary-disease-medications-in-primary-care-role-of-age-disease-burden-and-polypharmacy
#9
Davide L Vetrano, Elisa Bianchini, Graziano Onder, Iacopo Cricelli, Claudio Cricelli, Roberto Bernabei, Germano Bettoncelli, Francesco Lapi
AIM: The aim of the present study was to assess the occurrence and determinants of poor adherence to pharmacological treatment in a cohort of primary care patients with chronic obstructive pulmonary disease (COPD), paying special attention to the role of age, comorbidity and polypharmacy. METHODS: We identified a cohort of COPD patients using the primary care Italian Health Search - IMS Longitudinal Patient Database. We assessed 1-year adherence to COPD maintenance pharmacotherapy (encompassing inhaled corticosteroids, long-acting beta agonists and long-acting anticholinergics)...
June 28, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28654410/audiologic-assessment-in-adults-with-down-syndrome
#10
Pasqualina M Picciotti, Angelo Carfì, Roberta Anzivino, Gaetano Paludetti, Guido Conti, Vincenzo Brandi, Roberto Bernabei, Graziano Onder
Increased life expectancy in persons with Down syndrome (DS) is associated with premature age-related changes. The aim of this study was to assess auditory function in adults with DS and to evaluate the prevalence of hearing loss in this population. Audiometric tests were performed in 72 adults with DS (mean age 37.3±10.1 years, 51.4% females). Air conduction pure tone average (PTA) thresholds at frequencies 0.5-1-2-4 kHz were calculated to assess hearing function. Hearing loss was present if the PTA threshold was > 20 dB hearing level...
July 2017: American Journal on Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/28254182/herbal-medications-in-cardiovascular%C3%A2-medicine
#11
REVIEW
Rosa Liperoti, Davide L Vetrano, Roberto Bernabei, Graziano Onder
Herbal medications are commonly used for clinical purposes, including the treatment of cardiovascular conditions. Compared with conventional medications, herbal medications do not require clinical studies before their marketing or formal approval from regulatory agencies, and for this reason their efficacy and safety are rarely proven. In this review, we summarize available evidence on herbal medications mostly used in cardiovascular medicine. We show that the use of these medications for the treatment of cardiovascular diseases is often not supported by scientific evidence...
March 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28238677/improving-public-awareness-of-multimorbidity
#12
EDITORIAL
Alessandra Marengoni, Laura Fratiglioni, Graziano Onder
No abstract text is available yet for this article.
May 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28129493/antipsychotic-drug-interactions-and-mortality-among-nursing-home-residents-with-cognitive-impairment
#13
Rosa Liperoti, Federica Sganga, Francesco Landi, Eva Topinkova, Michael D Denkinger, Henriëtte G van der Roest, Andrea D Foebel, Harriet Finne-Soveri, Roberto Bernabei, Graziano Onder
OBJECTIVE: Among elderly individuals with dementia, the use of antipsychotics has been associated with serious adverse events including ischemic stroke and death. Multiple medications can interact with antipsychotics and increase the risk of such adverse events. The purpose of this retrospective, longitudinal cohort study was to estimate the prevalence of potential antipsychotic drug interactions and their effect on increasing the risk of death among cognitively impaired elderly individuals treated with antipsychotics...
January 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28126135/prevention-of-functional-decline-by-reframing-the-role-of-nursing-homes
#14
Clarisse Laffon de Mazières, John E Morley, Cari Levy, Fabien Agenes, Mario Barbagallo, Matteo Cesari, Philipe De Souto Barreto, Lorenzo Maria Donini, Jaime Fitten, Alain Franco, Mikel Izquierdo, Rosalie A Kane, Finbarr C Martin, Graziano Onder, Joseph Ouslander, Kaisu Pitkälä, Debra Saliba, Alan Sinclair, Leocadio Rodriguez Manas, Bruno Vellas, Yves Rolland
Institutionalization is generally a consequence of functional decline driven by physical limitations, cognitive impairments, and/or loss of social supports. At this stage, intervention to reverse functional losses is often too late. To be more effective, geriatric medicine must evolve to intervene at an earlier stage of the disability process. Could nursing homes (NHs) transform from settings in which many residents dwell to settings in which the NH residents and those living in neighboring communities benefit from staff expertise to enhance quality of life and maintain or slow functional decline? A task force of clinical researchers met in Toulouse on December 2, 2015, to address some of these challenges: how to prevent or slow functional decline and disabilities for NH residents and how NHs may promote the prevention of functional decline in community-dwelling frail elderly...
February 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28111156/defining-a-care-pathway-for-patients-with-multimorbidity-or-frailty
#15
EDITORIAL
Graziano Onder, Matteo Cesari, Marcello Maggio, Katie Palmer
No abstract text is available yet for this article.
March 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28003375/assessing-and-measuring-chronic-multimorbidity-in-the-older-population-a-proposal-for-its-operationalization
#16
Amaia Calderón-Larrañaga, Davide L Vetrano, Graziano Onder, Luis A Gimeno-Feliu, Carlos Coscollar-Santaliestra, Angelo Carfí, Maria S Pisciotta, Sara Angleman, René J F Melis, Giola Santoni, Francesca Mangialasche, Debora Rizzuto, Anna-Karin Welmer, Roberto Bernabei, Alexandra Prados-Torres, Alessandra Marengoni, Laura Fratiglioni
Background: Although the definition of multimorbidity as "the simultaneous presence of two or more chronic diseases" is well established, its operationalization is not yet agreed. This study aims to provide a clinically driven comprehensive list of chronic conditions to be included when measuring multimorbidity. Methods: Based on a consensus definition of chronic disease, all four-digit level codes from the International Classification of Diseases, 10th revision (ICD-10) were classified as chronic or not by an international and multidisciplinary team...
October 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28000156/predicting-the-risk-of-adverse-drug-reactions-in-older-inpatients-external-validation-of-the-gerontonet-adr-risk-score-using-the-crime-cohort
#17
Mirko Petrovic, Balamurugan Tangiisuran, Chakravarthi Rajkumar, Tischa van der Cammen, Graziano Onder
BACKGROUND: Adverse drug reactions (ADRs) in older people are often preventable, indicating that screening and prevention programs aimed at reducing their rate are needed in this population. OBJECTIVE: The aim of this study was to externally validate the GerontoNet ADR risk score and to assess its validity in specific subpopulations of older inpatients. METHODS: Data from the prospective CRIteria to assess appropriate Medication use among Elderly complex patients (CRIME) cohort were used...
February 2017: Drugs & Aging
https://www.readbyqxmd.com/read/27868320/predictors-of-rehospitalization-among-older-adults-results-of-the-crime-study
#18
Federica Sganga, Francesco Landi, Stefano Volpato, Antonio Cherubini, Carmelinda Ruggiero, Andrea Corsonello, Paolo Fabbietti, Fabrizia Lattanzio, Ester Manes Gravina, Roberto Bernabei, Graziano Onder
AIM: To assess the predictors of readmission among older adults hospitalized in acute care wards. METHODS: A prospective cohort study was carried out among 921 hospitalized older adults participating in the CRiteria to Assess Appropriate Medication Use among Elderly Complex Patients (CRIME) project. The primary outcome of the study was rehospitalization within 1 year after discharge from acute care hospitals. We assessed the participants with a questionnaire including 350 items about demographic, social and clinical characteristics...
November 21, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27862784/does-being-assisted-by-care-workers-affect-antipsychotics-prescription-among-older-people-discharged-from-hospital
#19
Mirko Di Rosa, Paolo Fabbietti, Andrea Corsonello, Sergio Fusco, Federica Sganga, Stefano Volpato, Carmelinda Ruggiero, Graziano Onder, Fabrizia Lattanzio
AIM: Several factors can affect antipsychotic prescriptions, among which, caregivers. However, whether being assisted by a care worker might increase the rate of antipsychotic prescriptions at discharge from acute care hospital has not been previously investigated. We aimed to investigate whether being assisted by a care worker is associated with increased use of antipsychotics among older patients discharged from acute care hospitals. METHODS: The present series consisted of 928 patients not taking antipsychotics at admission in seven acute care wards of geriatric medicine in Italy (mean age 80...
November 10, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27813416/social-and-functional-health-of-home-care-clients-with-different-levels-of-cognitive-impairments
#20
Vjenka Garms-Homolová, Nanna Notthoff, Anja Declercq, Henriette G van der Roest, Graziano Onder, Pálmi Jónsson, Hein van Hout
OBJECTIVES: The ability to manage one's life with some degree of independence, to fulfill basic obligations, and to participate in social activities are social functions that delineate the core of 'social health'. We examine to what extent clients of community care in Europe (n = 2884) complete such activities despite their cognitive problems. We focus on mildly and moderately impaired people, aged 65+ years. METHODS: Data were collected using the interRAI HC-Assessment in IBenC-project...
January 2017: Aging & Mental Health
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