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graziano Onder

Maria Lorenzi, Stefano Bonassi, Teresa Lorenzi, Silvia Giovannini, Roberto Bernabei, Graziano Onder
Sarcopenia and frailty are associated with several important health-related adverse events, including disability, loss of independence, institutionalization and mortality. Sarcopenia can be considered a biological substrate of frailty, and the prevalence of both these conditions progressively increases with age. Telomeres are nucleoprotein structures located at the end of linear chromosomes and implicated in cellular ageing, shorten with age, and are associated with various age-related diseases. In addition, telomere length (TL) is widely considered a molecular/cellular hallmark of the ageing process...
March 16, 2018: Biogerontology
Graziano Onder, Davide L Vetrano, Alessandra Marengoni, J Simon Bell, Kristina Johnell, Katie Palmer
Chronic diseases are considered to be major determinants of frailty and it could be hypothesized that their treatment may counteract the development of frailty. However, the hypothesis that intensive treatment of chronic diseases might reduce the progression of frailty is poorly supported by existing studies. In contrast, some evidence suggests that intensive treatment of chronic diseases may increase negative health outcomes in frail older adults. In particular, if treatment of symptoms related to chronic diseases (i...
March 8, 2018: European Journal of Internal Medicine
Davide L Vetrano, Debora Rizzuto, Amaia Calderón-Larrañaga, Graziano Onder, Anna-Karin Welmer, Roberto Bernabei, Alessandra Marengoni, Laura Fratiglioni
BACKGROUND: Functional decline is a strong health determinant in older adults, and chronic diseases play a major role in this age-related phenomenon. In this study, we explored possible clinical pathways underlying functional heterogeneity in older adults by quantifying the impact of cardiovascular (CV) and neuropsychiatric (NP) chronic diseases and their co-occurrence on trajectories of functional decline. METHODS AND FINDINGS: We studied 2,385 people ≥60 years (range 60-101 years) participating in the Swedish National study of Aging and Care in Kungsholmen (SNAC-K)...
March 2018: PLoS Medicine
Abdul Aziz Al Wazzan, Eline Tommelein, Katrien Foubert, Stefano Bonassi, Graziano Onder, Annemie Somers, Mirko Petrovic, Koen Boussery
BACKGROUND: Renal function progressively worsens with age. Potentially inappropriate prescribing (PIP) of renally excreted active drugs (READs) is common in older adults, leading to an increased rate of iatrogenic illness. The Ghent Older People's Prescription community Pharmacy Screening (GheOP3 S-) tool is an effective, explicit instrument that was developed for community pharmacists (CPs) to detect PIP. So far, this tool does not assess PIP of the frequently used READs in older patients with renal impairment...
March 5, 2018: Drugs & Aging
Alessandra Marengoni, Davide L Vetrano, Ester Manes-Gravina, Roberto Bernabei, Graziano Onder, Katie Palmer
BACKGROUND: Frailty is common in seniors, and is characterized by diminished physiological reserves and increased vulnerability to stressors. Frailty can change the prognosis and treatment approach of several chronic diseases, including chronic obstructive pulmonary disease (COPD). The association between frailty and COPD has never been systematically reviewed. OBJECTIVES: To conduct a systematic review and meta-analysis assessing the association of COPD with frailty and pre-frailty...
February 22, 2018: Chest
Thomas Windhaber, Maria Lamprini Koula, Evangelia Ntzani, Alexandra Velivasi, Evangelos Rizos, Michail Theofilos Doumas, Evangelos Elias Pappas, Graziano Onder, Davide Liborio Vetrano, Angel Roudriguez Laso, Leocadio Roudriguez Manjas, Maddalena Illario, Regina Elisabeth Roller-Wirnsberger
BACKGROUND: In addition to the normal process of ageing, frailty, defined as a geriatric syndrome, is becoming more prevalent. Around 10% of people over 65 years and 25-50% of those aged over 85 years are frail. Frail elderly are more vulnerable to external stressors and have an increased risk of adverse health outcomes. To tackle these challenges, European Union (EU) member states need to develop a health work force capable of the right skills mix. A goal-centred education and training of professionals is crucial for effective and efficient health care delivery for Europe's greying population...
February 23, 2018: Aging Clinical and Experimental Research
Katie Palmer, Graziano Onder
No abstract text is available yet for this article.
February 19, 2018: European Journal of Internal Medicine
Silvia Giovannini, Henriëtte G van der Roest, Angelo Carfì, Harriet Finne-Soveri, Vjenka Garms-Homolová, Anja Declercq, Pálmi V Jónsson, Hein van Hout, Davide L Vetrano, Ester Manes Gravina, Roberto Bernabei, Graziano Onder
BACKGROUND: Home care (HC) patients are characterized by a high level of complexity, which is reflected by the prevalence of multimorbidity and the correlated high drug consumption. This study assesses prevalence and factors associated with polypharmacy in a sample of HC patients in Europe. METHODS: We conducted a cross-sectional analysis on 1873 HC patients from six European countries participating in the Identifying best practices for care-dependent elderly by Benchmarking Costs and outcomes of community care (IBenC) project...
February 6, 2018: Drugs & Aging
Davide L Vetrano, Maria S Pisciotta, Alice Laudisio, Maria R Lo Monaco, Graziano Onder, Vincenzo Brandi, Domenico Fusco, Beatrice Di Capua, Diego Ricciardi, Roberto Bernabei, Giuseppe Zuccalà
OBJECTIVES: In Parkinson disease (PD), sarcopenia may represent the common downstream pathway that from motor and nonmotor symptoms leads to the progressive loss of resilience, frailty, and disability. Here we (1) assessed the prevalence of sarcopenia in older adults with PD using 3 different criteria, testing their agreement, and (2) evaluated the association between PD severity and sarcopenia. DESIGN: Cross-sectional, observation study. SETTING: Geriatric day hospital...
January 30, 2018: Journal of the American Medical Directors Association
Giuseppe Roberto, Claudia Bartolini, Federico Rea, Graziano Onder, Cristiana Vitale, Gianluca Trifirò, Ursula Kirchmayer, Alessandro Chinellato, Ersilia Lucenteforte, Giovanni Corrao, Alessandro Mugelli, Francesco Lapi, Rosa Gini
OBJECTIVES: To describe NSAID utilization for musculoskeletal conditions in a large cohort of Italian elderly with cerebro/cardiovascular disease, a population in which NSAIDs should be generally avoided due to the prothrombotic potential. METHODS: Administrative data from five Italian geographic areas were analyzed. Patients aged ≥ 65 with a cerebro/cardiovascular event recorded between 2008 and 2011 (cohort entry) were selected. Prescription NSAIDs reimbursed for musculoskeletal conditions and dispensed during 1 year follow-up were retrieved to describe (i) prevalence of use, (ii) average amount of defined daily doses of NSAIDs claimed by users per day of follow-up, and (iii) distribution of the received daily dose (RDD) among patients with ≥ 2 dispensings...
January 30, 2018: European Journal of Clinical Pharmacology
Edwin C K Tan, Janet K Sluggett, Kristina Johnell, Graziano Onder, Monique Elseviers, Lucas Morin, Davide L Vetrano, Jonas W Wastesson, Johan Fastbom, Heidi Taipale, Antti Tanskanen, J Simon Bell
Medication management is becoming increasingly challenging for older people, and there is limited evidence to guide medication prescribing and administration for people with multimorbidity, frailty, or at the end of life. Currently, there is a lack of clear research priorities in the field of geriatric pharmacotherapy. To address this issue, international experts from 5 research groups in geriatric pharmacotherapy and pharmacoepidemiology research were invited to attend the inaugural Optimizing Geriatric Pharmacotherapy through Pharmacoepidemiology Network workshop...
March 2018: Journal of the American Medical Directors Association
Graziano Onder, Silvia Giovannini, Federica Sganga, Ester Manes-Gravina, Eva Topinkova, Harriet Finne-Soveri, Vjenka Garms-Homolová, Anja Declercq, Henriëtte G van der Roest, Pálmi V Jónsson, Hein van Hout, Roberto Bernabei
AIM: Drugs may interact with geriatric syndromes by playing a role in the continuation, recurrence or worsening of these conditions. Aim of this study is to assess the prevalence of interactions between drugs and three common geriatric syndromes (delirium, falls and urinary incontinence) among older adults in nursing home and home care in Europe. METHODS: We performed a cross-sectional multicenter study among 4023 nursing home residents participating in the Services and Health for Elderly in Long-TERm care (Shelter) project and 1469 home care patients participating in the Identifying best practices for care-dependent elderly by Benchmarking Costs and outcomes of community care (IBenC) project...
January 16, 2018: Aging Clinical and Experimental Research
Karlijn J Joling, Liza van Eenoo, Davide L Vetrano, Veerle R Smaardijk, Anja Declercq, Graziano Onder, Hein P J van Hout, Henriëtte G van der Roest
BACKGROUND: Health care systems that succeed in preventing long term care and hospital admissions of frail older people may substantially save on their public spending. The key might be found in high-quality care in the community. Quality Indicators (QIs) of a sufficient methodological level are a prerequisite to monitor, compare, and improve care quality. This systematic review identified existing QIs for community care for older people and assessed their methodological quality. METHODS: Relevant studies were identified by searches in electronic reference databases and selected by two reviewers independently...
2018: PloS One
Andrea Poscia, Jovana Stojanovic, Daniele Ignazio La Milia, Mariusz Duplaga, Marcin Grysztar, Umberto Moscato, Graziano Onder, Agnese Collamati, Walter Ricciardi, Nicola Magnavita
This systematic review aims to summarize and update the current knowledge on the effectiveness of the existing interventions for alleviating loneliness and social isolation among older persons. A search of PubMed, ISI Web of science, SCOPUS, The Cochrane Library, and CINAHL databases was performed. The terminology combined all possible alternatives of the following keywords: social isolation, loneliness, old people, intervention and effectiveness. Eligible studies were published between January 2011 and February 2016 in English or Italian language and regarded the implementation of loneliness/social isolation interventions among the older generations...
February 2018: Experimental Gerontology
Davide L Vetrano, Agnese Collamati, Nicola Magnavita, Agnieszka Sowa, Eva Topinkova, Harriet Finne-Soveri, Henriëtte G van der Roest, Beata Tobiasz-Adamczyk, Silvia Giovannini, Walter Ricciardi, Roberto Bernabei, Graziano Onder, Andrea Poscia
OBJECTIVE: The care processes directed towards institutionalized older people needs to be tailored on goals and priorities that are relevant for this specific population. The aim of the present study was (a) to describe the distribution of selected health determinants in a sample of institutionalized older adults, and (b) to investigate the impact on survival of such measures. DESIGN: Multicentre longitudinal cohort-study. SETTING: 57 nursing homes (NH) in 7EU countries (Czech Republic, England, Finland, France, Germany, Italy, The Netherlands) and 1 non-EU country (Israel)...
January 2018: Maturitas
Graziano Onder, Alessandra Marengoni
No abstract text is available yet for this article.
November 7, 2017: JAMA: the Journal of the American Medical Association
Andrea Poscia, Agnese Collamati, Angelo Carfì, Eva Topinkova, Tomas Richter, Michael Denkinger, Roberta Pastorino, Francesco Landi, Walter Ricciardi, Roberto Bernabei, Graziano Onder
Background: Influenza and pneumococcal vaccines have been proved to be effective and safe in preventing and controlling infection among elderly, reducing morbidity and mortality. However, some evidences raised health concerns related to these vaccinations. This study aims to identify prevalence and outcomes related to influenza and pneumococcal vaccinations in a large European population of frail old people living in nursing homes (NHs). Methods: We conducted a survival analysis of NH residents participating to the Services and Health for Elderly in Long-TERm project, a prospective cohort study collecting information on residents admitted to 57 NH in eight countries (Czech Republic, England, Finland, France, Germany, Italy, The Netherlands and Israel)...
December 1, 2017: European Journal of Public Health
Liza Van Eenoo, Henriëtte van der Roest, Graziano Onder, Harriet Finne-Soveri, Vjenka Garms-Homolova, Palmi V Jonsson, Stasja Draisma, Hein van Hout, Anja Declercq
BACKGROUND: Decision makers are searching for models to redesign home care and to organize health care in a more sustainable way. OBJECTIVES: The aim of this study is to identify and characterize home care models within and across European countries by means of structural characteristics and care processes at the policy and the organization level. DATA SOURCES: At the policy level, variables that reflected variation in health care policy were included based on a literature review on the home care policy for older persons in six European countries: Belgium, Finland, Germany, Iceland, Italy, and the Netherlands...
September 21, 2017: International Journal of Nursing Studies
Alessandra Bettiol, Ersilia Lucenteforte, Alfredo Vannacci, Niccolò Lombardi, Graziano Onder, Nera Agabiti, Cristiana Vitale, Gianluca Trifirò, Giovanni Corrao, Giuseppe Roberto, Alessandro Mugelli, Alessandro Chinellato
BACKGROUND AND OBJECTIVES: Antihypertensive treatment with calcium channel blockers (CCBs) is consolidated in clinical practice; however, different studies observed increased risks of acute events for short-acting CCBs. This study aimed to provide real-world evidence on risks of acute cardiovascular (CV) events, hospitalizations and mortality among users of different CCB classes in secondary CV prevention. METHODS: Three case-control studies were nested in a cohort of Italian elderly hypertensive CV-compromised CCBs users...
December 2017: Clinical Drug Investigation
Katie Palmer, Alessandra Marengoni, Maria João Forjaz, Elena Jureviciene, Tiina Laatikainen, Federica Mammarella, Christiane Muth, Rokas Navickas, Alexandra Prados-Torres, Mieke Rijken, Ulrike Rothe, Laurène Souchet, Jose Valderas, Theodore Vontetsianos, Jelka Zaletel, Graziano Onder
Patients with multimorbidity have complex health needs but, due to the current traditional disease-oriented approach, they face a highly fragmented form of care that leads to inefficient, ineffective, and possibly harmful clinical interventions. There is limited evidence on available integrated and multidimensional care pathways for multimorbid patients. An expert consensus meeting was held to develop a framework for care of multimorbid patients that can be applied across Europe, within a project funded by the European Union; the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS)...
January 2018: Health Policy
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