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graziano Onder

Davide L Vetrano, Domenico La Carpia, Giulia Grande, Paola Casucci, Tiziana Bacelli, Roberto Bernabei, Graziano Onder
OBJECTIVES: To assess the association of the anticholinergic medication burden with hospitalization and mortality in nursing home elderly patients and to investigate the role of coronary artery disease (CAD). DESIGN: Longitudinal (5-year) retrospective observational study. SETTING: Nursing homes in Italy. PARTICIPANTS: A total of 3761 nursing home older residents. MEASUREMENTS: A comprehensive clinical and functional assessment was carried out through the interRAI long-term care facility instrument...
August 30, 2016: Journal of the American Medical Directors Association
Lisanne I van Lier, Henriëtte G van der Roest, Hein P J van Hout, Liza van Eenoo, Anja Declercq, Vjenka Garms-Homolová, Graziano Onder, Harriet Finne-Soveri, Pálmi V Jónsson, Cees M P M Hertogh, Judith E Bosmans
BACKGROUND: The interRAI-Home Care (interRAI-HC) instrument is commonly used in routine care to assess care and service needs, resource utilisation and health outcomes of community dwelling home care clients. Potentially, the interRAI-HC can also be used to calculate societal costs in economic evaluations. The purpose of this study was to assess the convergent validity of the interRAI-HC instrument in comparison with the RUD Lite instrument for the calculation of societal costs among care-dependent community dwelling older adults...
2016: BMC Health Services Research
Francesco Landi, Riccardo Calvani, Matteo Tosato, Anna Maria Martone, Roberto Bernabei, Graziano Onder, Emanuele Marzetti
OBJECTIVE: Sarcopaenia and physical function impairment may have a greater effect on survival than other clinical characteristics, including multimorbidity. In this study, we evaluated the impact of sarcopaenia on all-cause mortality and the interaction among muscle loss, physical function impairment and multimorbidity on mortality risk over 10 years in older community-dwellers. DESIGN: Prospective cohort study. SETTING: Population-based study...
2016: BMJ Open
Alessandra Marengoni, Alessandro Monaco, Elisio Costa, Antonio Cherubini, Alexandra Prados-Torres, Christiane Muth, Renè J F Melis, Luca Pasina, Tischa J M van der Cammen, Katie Palmer, Sergio Pecorelli, Graziano Onder
Poor adherence to treatment regimens has long been recognized as a substantial roadblock to achieving better outcomes for patients. Non-adherence to medications affects the quality and length of life and has been associated with negative health outcomes and increasing healthcare costs. The problem of non-adherence is particularly troublesome in older patients who are affected by multiple chronic diseases and for this reason receive multiple treatments. To date, no single intervention strategy has been shown to be effective in improving adherence across all patients, conditions, and settings...
September 2016: Drugs & Aging
Katarzyna Szczerbińska, Eva Topinková, Piotr Brzyski, Henriette G van der Roest, Tomáš Richter, Harriet Finne-Soveri, Michael D Denkinger, Jacob Gindin, Graziano Onder, Roberto Bernabei
OBJECTIVES: To describe health care and preventive service provision to nursing home (NH) residents with diabetes mellitus (DM) and to analyze factors determining use of selected services. DESIGN: In the period between 2009 and 2011, the Services and Health for Elderly in Long TERm care (SHELTER) project, a 12-month prospective cohort study, was conducted to assess 4037 NH residents aged 60 years and older residing in 59 NHs in 7 European countries and Israel. METHODS: The InterRAI tool for long-term care facilities was used to assess care needs and provided health care services...
September 1, 2016: Journal of the American Medical Directors Association
Sven Stegemann, Robert L Ternik, Graziano Onder, Mansoor A Khan, Diana A van Riet-Nales
The term "patient centered," "patient centric," or "patient centricity" is increasingly used in the scientific literature in a wide variety of contexts. Generally, patient centric medicines are recognized as an essential contributor to healthy aging and the overall patient's quality of life and life expectancy. Besides the selection of the appropriate type of drug substance and strength for a particular indication in a particular patient, due attention must be paid that the pharmaceutical drug product design is also adequately addressing the particular patient's needs, i...
September 2016: AAPS Journal
Petra Hopman, Simone R de Bruin, Maria João Forjaz, Carmen Rodriguez-Blazquez, Giuseppe Tonnara, Lidwien C Lemmens, Graziano Onder, Caroline A Baan, Mieke Rijken
OBJECTIVE: To describe comprehensive care programs targeting multimorbid and/or frail patients and to estimate their effectiveness regarding improvement of patient and caregiver related outcomes, healthcare utilization and costs. METHODS: Systematic search in six electronic databases for scientific papers published between January 2011 and March 2014, supplemented by reference tracking. Wagner's Chronic Care Model (CCM) was used to operationalize comprehensive care...
July 2016: Health Policy
Sabrina Garasto, Sergio Fusco, Graziano Onder, Federica Sganga, Federica Mammarella, Stefano Volpato, Carmelinda Ruggiero, Angela M Abbatecola, Fabrizia Lattanzio, Andrea Corsonello
AIM: To investigate the prevalence and clinical correlates of overprescribing and underprescribing of low molecular weight heparins (LMWHs) for thromboprophylaxis among older medical inpatients. METHODS: Eight hundred seventy six patients (mean age 81.5 ± 7.6 years, female gender 57.2 %) enrolled in a multicenter observational study of seven acute care wards of geriatric medicine in Italy. The risk of venous thromboembolism was ascertained by calculating the Padua score for each patient...
April 25, 2016: Aging Clinical and Experimental Research
Graziano Onder, Alessandra Marengoni
No abstract text is available yet for this article.
June 2016: European Journal of Internal Medicine
Maria Lorenzi, Teresa Lorenzi, Emanuele Marzetti, Francesco Landi, Davide L Vetrano, Silvana Settanni, Manuela Antocicco, Stefano Bonassi, Vanessa Valdiglesias, Roberto Bernabei, Graziano Onder
Frailty is a geriatric syndrome characterized by multi system dysregulation. It has been suggested that chronic inflammation may be involved in the pathogenesis of frailty. No study so far has identified accurate, specific and sensitive molecular biomarkers for frailty. High-temperature requirement serine protease A1 (HtrA1) is a secreted multidomain serine protease implicated in the inhibition of signaling of active transforming growth factor-β (TGF-β)1, a cytokine which has an important anti-inflammation role...
August 2016: Experimental Gerontology
Francesco Landi, Riccardo Calvani, Maria Lorenzi, Anna Maria Martone, Matteo Tosato, Michael Drey, Emanuela D'Angelo, Ettore Capoluongo, Andrea Russo, Roberto Bernabei, Graziano Onder, Emanuele Marzetti
BACKGROUND: The C-terminal agrin fragment (CAF), a circulating byproduct of neuromuscular junction disassembly, has been proposed as a possible biomarker for sarcopenia. However, its validity in "real-world", multimorbid older persons is currently unknown. The present study was undertaken to verify if serum CAF levels were associated with sarcopenia in a population of old and very old persons living in the community. METHODS: Data were from the ilSIRENTE Aging and Longevity Study, a prospective cohort study conducted in all persons aged 80years and older residing in the Sirente geographic area (Italy; n=332)...
June 15, 2016: Experimental Gerontology
Graziano Onder, Rosa Liperoti
No abstract text is available yet for this article.
March 8, 2016: JAMA: the Journal of the American Medical Association
Carlotta Franchi, Mauro Tettamanti, Codjo Dgnefa Djade, Luca Pasina, Pier Mannuccio Mannucci, Graziano Onder, Gualberto Gussoni, Dario Manfellotto, Stefano Bonassi, Francesco Salerno, Alessandro Nobili
AIMS: The aim of the study was to evaluate the effect of an e-learning educational program meant to foster the quality of drug prescription in hospitalized elderly patients. METHODS: Twenty geriatric and internal medicine wards were randomized to intervention (e-learning educational program) or control (basic geriatric pharmacology notions). Logistic regression analysis was used in order to assess the effect of the intervention on the use of potentially inappropriate medication (PIM, primary outcome) at hospital discharge...
July 2016: British Journal of Clinical Pharmacology
Mirko Petrovic, Annemie Somers, Graziano Onder
Because older patients are more vulnerable to adverse drug-related events, there is a need to ensure appropriate pharmacotherapy in these patients. This narrative review describes approaches to improve pharmacotherapy in older people in the hospital setting. Screening to identify older patients at risk of drug-related problems and adverse drug reactions (ADRs) is the first critical step within a multistep approach to geriatric pharmacotherapy. Two methods that have been developed are the GerontoNet ADR risk score and the Brighton Adverse Drug Reactions Risk (BADRI) model, which take into account a number of factors, the most important of which is the number of medicines...
March 2016: Drugs & Aging
Andrea Tringali, Federico Barbaro, Margherita Pizzicannella, Ivo Boškoski, Pietro Familiari, Vincenzo Perri, Giovanni Gigante, Graziano Onder, Cesare Hassan, Raffaella Lionetti, Giuseppe Maria Ettorre, Guido Costamagna
BACKGROUND AND AIMS: Anastomotic biliary stricture (ABS) is the most common biliary complication after orthotopic liver transplantation (OLT) and can be successfully managed endoscopically. The long-term results of a protocol using placement of multiple plastic stents to treat ABS following OLT were analyzed. METHODS: All patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) for OLT-related biliary complications at our Endoscopy Unit between July 1994 and March 2012 were retrospectively identified from the ERCP database...
June 2016: Endoscopy
Andrea D Foebel, Graziano Onder, Harriet Finne-Soveri, Albert Lukas, Michael D Denkinger, Angelo Carfi, Davide L Vetrano, Vincenzo Brandi, Roberto Bernabei, Rosa Liperoti
PURPOSE: To explore antipsychotic (AP) medications and physical restraint use and their effects on physical function and cognition in older nursing home residents. METHODS: This retrospective cohort studied involved 532 residents with dementia from 57 nursing homes participating in the Services and Health for Elderly in Long-Term Care study. Poisson log regression models explored the effect of physical restraint and/or AP medication use on cognitive or functional decline at 6 months...
February 2016: Journal of the American Medical Directors Association
Davide L Vetrano, Andrea D Foebel, Alessandra Marengoni, Vincenzo Brandi, Agnese Collamati, George A Heckman, John Hirdes, Roberto Bernabei, Graziano Onder
BACKGROUND: Comorbidity is a relevant health determinant in older adults. Co-occurrence of several diseases and other age-associated conditions generates new clinical phenotypes (geriatric syndromes [GS] as falls, delirium etc.). We investigated the association of chronic diseases, alone or in combination, and GS in older adults receiving home care services in 11 European countries and one Canadian province. METHODS: Participants were cross-sectionally evaluated with the multidimensional assessment instrument RAI HC...
January 2016: European Journal of Internal Medicine
Davide L Vetrano, Angelo Carfì, Vincenzo Brandi, Paolo D L'Angiocola, Sonia Di Tella, Maria Camilla Cipriani, Manuela Antocicco, Giuseppe Zuccalà, Vincenzo Palmieri, Maria Caterina Silveri, Roberto Bernabei, Graziano Onder
No abstract text is available yet for this article.
January 15, 2016: International Journal of Cardiology
Alessandra Marengoni, Alessandro Nobili, Graziano Onder
Achievement of a good quality of prescribing is one of the major challenges for physicians caring for older persons, because of aging-related changes in pharmacokinetics and pharmacodynamics of drugs, the large number of co-occurring chronic diseases affecting older adults and consequent polypharmacy. Several approaches are available and have been used to tackle over-prescription of drugs, such as medication review, application of appropriateness criteria and computerized prescription support systems, but, one by one, they have shown limited effectiveness with respect to patient-centred outcomes...
November 2015: Drugs & Aging
Yukari Yamada, Michael D Denkinger, Graziano Onder, Henriëtte G van der Roest, Harriet Finne-Soveri, Roberto Bernabei, Eva Topinkova
BACKGROUND: Concurrent vision and hearing impairment, known as dual sensory impairment (DSI), is associated with increased mortality. We aimed to examine individual and joint associations of DSI and involvement in activities with mortality in a large European nursing home study. METHODS: In total, 2,851 nursing home residents in 59 facilities in eight countries were followed for 1 year in the Services and Health for Elderly in Long TERm Care study. Vision and hearing impairment and average time of involvement in activities were assessed by trained research staff using the interRAI Long Term Care Facilities...
May 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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