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https://www.readbyqxmd.com/read/28334650/ultrasensitive-determination-of-dna-oxidation-products-by-gas-chromatography-tandem-mass-spectrometry-and-the-role-of-antioxidants-in-the-prevention-of-oxidative-damage
#1
Sam Dawbaa, Önder Aybastıer, Cevdet Demir
Oxidative stress is considered as one of the significant causes of DNA damage which in turn contributes to cell death through a series of intermediate processes such as cancer formation, mutation, and aging. Natural sources such as plant and fruit products have provided us with interesting substances of antioxidant activity that could be recruited in protecting the genetic materials of the cells. This study is an effort to discover some of those antioxidants effects in their standard and natural forms by performing an ultrasensitive determination of the products of DNA oxidation using GC-MS/MS...
March 16, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28319044/fibroblastic-niches-prime-t-cell-alloimmunity-through-delta-like-notch-ligands
#2
Jooho Chung, Christen L Ebens, Eric Perkey, Vedran Radojcic, Ute Koch, Leonardo Scarpellino, Alexander Tong, Frederick Allen, Sherri Wood, Jiane Feng, Ann Friedman, David Granadier, Ivy T Tran, Qian Chai, Lucas Onder, Minhong Yan, Pavan Reddy, Bruce R Blazar, Alex Y Huang, Todd V Brennan, D Keith Bishop, Burkhard Ludewig, Christian W Siebel, Freddy Radtke, Sanjiv A Luther, Ivan Maillard
Alloimmune T cell responses induce graft-versus-host disease (GVHD), a serious complication of allogeneic bone marrow transplantation (allo-BMT). Although Notch signaling mediated by Delta-like 1/4 (DLL1/4) Notch ligands has emerged as a major regulator of GVHD pathogenesis, little is known about the timing of essential Notch signals and the cellular source of Notch ligands after allo-BMT. Here, we have shown that critical DLL1/4-mediated Notch signals are delivered to donor T cells during a short 48-hour window after transplantation in a mouse allo-BMT model...
March 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28315787/the-synergistic-influence-of-ischemic-time-and-surgical-precision-on-acute-kidney-injury-after-robotic-partial-nephrectomy
#3
Julien Dagenais, Matt Maurice, Pascal Mouracade, Onder Kara, Ryan Nelson, Ercan Malkoc, Jihad Kaouk
OBJECTIVES: To examine the dynamic and potentially synergistic influence of warm ischemia time (WIT) and excisional volume loss (EVL) on predicted rates of post-partial acute kidney injury (AKI) across a range of tumor complexities. To investigate whether these modifiable variables sensitize the kidney to the other's damaging influence. METHODS: We retrospectively reviewed 1,245 patients between 2006 and 2016 with bilateral kidneys and enhancing renal masses in our single-institution robotic partial nephrectomy (PN) database...
March 15, 2017: Urology
https://www.readbyqxmd.com/read/28291292/-psychotic-experiences-in-the-adaptation-process-to-a-new-social-environment
#4
Tolga Binbay, Emre Mısır, Ebru Onrat Özsoydan, Mert Artuk, Simay Fidan, Arzu Karakiraz, Ezgi Önder, Arjin Öztürk, Merve Buse Sayın, Halis Ulaş, Berna Akdede, Köksal Alptekin
OBJECTIVE: To evaluate the association between psychotic experiences (PEs) and social stress and discrimination during adaptation to a new social context. METHOD: First-term university students (n: 164) were screened to determine if they had had any PEs, social adaptation-related stress, and/or perceived discrimination in the prior six months. The positive dimension of the Community Assessment of Psychic Experiences (CAPE) was used to define PEs. Social relations and discrimination in the students' new social contexts (both narrow (i...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28272675/what-does-the-data-of-354-725-patients-from-turkey-tell-us-about-cervical-smear-epithelial-cell-abnormalities-the-epithelial-cell-abnormality-rate-is-increasing-quality-control-studies-and-corrective-activity-are-musts
#5
İlknur Çetinaslan Türkmen, Alp Usubütün, Aslı Çakir, Özlem Aydin, Filiz Aka Bolat, Metin Akbulut, Serdar Altinay, Sema Arici, Figen Aslan, Müzeyyen Astarci, Emine Kılıç Bağir, Yılmaz Baş, Nuray Başsüllü, Betül Çelik, Handan Çetiner, Bengü Çobanoğlu, Abdullah Aydin, Hale Demir, Hayriye Tatlı Doğan, Kamile Gülçin Eken, Selma Şengiz Erhan, Gülgün Erdoğan, Kıvılcım Eren Erdoğan, Funda Eren, Şafak Ersöz, Pınar Firat, İclal Gürses, Nihan Haberal, Dudu Solakoğlu Kahraman, Gülçin Harman Kamali, Yasemin Yuyucu Karabulut, Mehmet Kefeli, Meral Koyuncuoğlu, R Doğan Köseoğlu, Bahar Müezzinoğlu, Binnur Onal, Sevgen Önder, Zuhal Özcan, Elife Kimiloğlu, Hatice Özer, F Cavide Sönmez, Sevinç Şahin, Nurhan Şahin, Tülin Yalta
OBJECTIVE: There is no other screening program close to the success rate of PAP test. Cervical cytology constitutes a large workload so that quality control in cervical cytology is important for the quality assurance of pathology laboratories. MATERIAL AND METHOD: In this study, we collected the cervical cytology results from all over Turkey and discussed the parameters influencing the quality of the PAP test. The study was conducted with Turkish gynaecopathology working group and 38 centers (totally 45 hospitals) agreed to contribute from 24 different cities...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272224/high-expression-of-sall4-and-fascin-and-loss-of-e-cadherin-expression-in-undifferentiated-dedifferentiated-carcinomas-of-the-endometrium-an-immunohistochemical-and-clinicopathologic-study
#6
Semen Onder, Orhun Cig Taskin, Fatma Sen, Samet Topuz, Seden Kucucuk, Hamdullah Sozen, Ridvan Ilhan, Sitki Tuzlali, Ekrem Yavuz
Undifferentiated/dedifferentiated endometrial carcinomas (UCE/DCEs) of the endometrium are rare tumors with poor prognosis. There are few clinicopathologic studies with detailed immunohistochemical analysis regarding UCE/DCEs.We evaluated the diagnostic value of a selected tumor stem-cell marker and epithelial-mesenchymal transition (EMT) markers, in addition to previously studied markers in identifying UCE/DCEs from other types of high-grade endometrial carcinomas.Eleven cases of UCE/DCEs with complete clinical follow-up that were diagnosed between 2006 and 2015 were included in the study...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28268749/design-of-a-bio-inspired-pneumatic-artificial-muscle-with-self-contained-sensing
#7
Onder Erin, Nishant Pol, Luis Valle, Yong-Lae Park
Pneumatic artificial muscles (PAMs) are one of the most famous linear actuators in bio-inspired robotics. They can generate relatively high linear force considering their form factors and weights. Furthermore, PAMs are inexpensive compared with traditional electromagnetic actuators (e.g. DC motors) and also inherently light and compliant. In robotics applications, however, they typically require external sensing mechanisms due to their nonlinear behaviors, which may make the entire mechanical system bulky and complicated, limiting their use in simple systems...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28259682/cross-cultural-validation-of-the-quality-of-life-in-hand-eczema-questionnaire-qolheq
#8
Robert F Ofenloch, Jart A F Oosterhaven, Päivikki Susitaival, Åke Svensson, Elke Weisshaar, Keiko Minamoto, Meltem Onder, Marie-Louise A Schuttelaar, Emel Bulbul Baskan, Thomas L Diepgen, Christian Apfelbacher
The Quality of Life in Hand Eczema Questionnaire (QOLHEQ) is the only instrument assessing disease-specific Health-Related Quality of Life (HRQOL) in hand eczema patients. It is available in eight language versions. In this study we assessed if the items of different language versions of the QOLHEQ yield comparable values across countries. An international multi-center study was conducted with participating centers in Finland, Germany, Japan, the Netherlands, Sweden and Turkey. Methods of item response theory (IRT) were applied to each subscale to assess differential item functioning (DIF) for items between countries...
March 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28259474/excisional-precision-matters-understanding-the-influence-of-excisional-volume-loss-on-renal-function-after-partial-nephrectomy
#9
Julien Dagenais, Matthew J Maurice, Pascal Mouracade, Onder Kara, Ercan Malkoc, Jihad H Kaouk
Renal function after partial nephrectomy (PN) may depend on modifiable factors including ischemia time, excision of healthy parenchyma (excisional volume loss, EVL), and reconstructive methods. We retrospectively reviewed our institutional robotic PN database to identify the predictors of glomerular filtration rate (GFR) preservation (GFR-P) at 3-12 mo postoperatively, during which GFR decline plateaus. Baseline clinical, sociodemographic, and radiologic characteristics were captured. Univariate and multivariate (MV) linear regression analyses were performed and marginal effects were employed to examine the relative effect of EVL on renal function...
March 1, 2017: European Urology
https://www.readbyqxmd.com/read/28254182/herbal-medications-in-cardiovascular%C3%A2-medicine
#10
REVIEW
Rosa Liperoti, Davide L Vetrano, Roberto Bernabei, Graziano Onder
Herbal medications are commonly used for clinical purposes, including the treatment of cardiovascular conditions. Compared with conventional medications, herbal medications do not require clinical studies before their marketing or formal approval from regulatory agencies, and for this reason their efficacy and safety are rarely proven. In this review, we summarize available evidence on herbal medications mostly used in cardiovascular medicine. We show that the use of these medications for the treatment of cardiovascular diseases is often not supported by scientific evidence...
March 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28251086/novel-biomarkers-for-patients-with-idiopathic-acute-anterior-uveitis-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio
#11
Cem Ozgonul, Erdim Sertoglu, Onder Ayyildiz, Tarkan Mumcuoglu, Murat Kucukevcilioglu, Gokcen Gokce, Ali Hakan Durukan
AIM: To assess the levels of the neutrophil to lymphocyte ratio (N/L) and the platelet to lymphocyte ratio (P/L) in patients with idiopathic acute anterior uveitis (AAU) and to compare with healthy controls. METHODS: Thirty-six male patients with idiopathic AAU and 36 male healthy subjects were enrolled in this retrospective study. Complete ophthalmological examination and complete blood count measurements results of all subjects were evaluated. RESULTS: There was a significant difference in N/L and P/L between idiopathic AAU and control groups (P=0...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28249141/blinatumomab-versus-chemotherapy-for-advanced-acute-lymphoblastic-leukemia
#12
RANDOMIZED CONTROLLED TRIAL
Hagop Kantarjian, Anthony Stein, Nicola Gökbuget, Adele K Fielding, Andre C Schuh, Josep-Maria Ribera, Andrew Wei, Hervé Dombret, Robin Foà, Renato Bassan, Önder Arslan, Miguel A Sanz, Julie Bergeron, Fatih Demirkan, Ewa Lech-Maranda, Alessandro Rambaldi, Xavier Thomas, Heinz-August Horst, Monika Brüggemann, Wolfram Klapper, Brent L Wood, Alex Fleishman, Dirk Nagorsen, Christopher Holland, Zachary Zimmerman, Max S Topp
Background Blinatumomab, a bispecific monoclonal antibody construct that enables CD3-positive T cells to recognize and eliminate CD19-positive acute lymphoblastic leukemia (ALL) blasts, was approved for use in patients with relapsed or refractory B-cell precursor ALL on the basis of single-group trials that showed efficacy and manageable toxic effects. Methods In this multi-institutional phase 3 trial, we randomly assigned adults with heavily pretreated B-cell precursor ALL, in a 2:1 ratio, to receive either blinatumomab or standard-of-care chemotherapy...
March 2, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28247274/metal-accumulations-in-different-tissues-of-cuttlefish-sepia-officinalis-l-1758-in-the-eastern-mediterranean-coasts-of-turkey
#13
Önder Duysak, Erkan Uğurlu
In this study, metal concentration levels (Cd, Co, Cr, Ni, and Pb) were investigated in the gill, hepatopancreas, ovary, testis, and mantle of the male and female cuttlefish Sepia officinalis in various stations (Iskenderun, Antalya, Kas, Gazipasa, and Anamur) in Mediterranean coasts of Turkey. Hepatopancreas tissue was a better indicator in terms of heavy metal concentration compared to the other tissues. In general, Cd, Co, Cr, Ni, and Pb accumulation for the male was found more than that of the female, whereas Cd and Ni accumulation was found higher in the female...
March 1, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28246523/re-distinguishing-between-renal-cell-carcinoma-and-fat-poor-angiomyolipoma-in-diffusion-weighted-imaging
#14
COMMENT
Ali Kemal Sivrioglu, Serkan Arıbal, Önder Hakan
No abstract text is available yet for this article.
March 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28246048/evaluation-of-symphysis-pubis-and-sacroiliac-joint-distances-in-skeletally-immature-patients-a-computerized-tomography-study-of-1020-individuals
#15
Önder Kalenderer, Ali Turgut, Tayfun Bacaksız, Emre Bilgin, Mert Kumbaracı, Hasan Ali Akkan
OBJECTIVE: The aim of this study was to create a reference about normal pubic symphysis and sacroiliac joint widths of children and adolescents. METHODS: A total of 1020 computerized tomography axial scans of patients without pelvic injury between 2 and 18 year-old were studied. The narrowest width of pubic symphysis and bilateral sacroiliac joints were measured. RESULTS: The average pubic symphyseal width at 2 years old boys was 6.35 ± 1...
February 25, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28246047/is-the-use-of-hemostatic-matrix-floseal-and-alkylene-oxide-copolymer-ostene-safe-in-spinal-laminectomies-peridural-fibrosis-assessment
#16
Oktay Gurcan, Ahmet Gurhan Gurcay, Atilla Kazanci, Evrim Onder, Salim Senturk, Murad Bavbek
OBJECTIVE: Failed Back Syndrome (FBS) is unacceptable relief of pain or recurrence of symptoms in patients after spinal surgery, such as laminectomy. One possible cause of FBS is peridural fibrosis (PF). PF is the overproduction of scar tissue adjacent to the dura mater. Bleeding can cause PF after laminectomy. Ostene is an alkylene oxide copolymer material used to stop bleeding from bony surfaces. Floseal is a gelatin thrombin matrix sealant used to assist fibrin formation and to promote coagulation...
February 25, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28243477/two-different-cell-populations-is-an-important-clue-for-diagnosis-of-primary-cutaneous-adenoid-cystic-carcinoma-immunohistochemical-study
#17
Banu Ince Alkan, Onder Bozdogan, Müjde Karadeniz, Nazan Bozdoğan
Primary cutaneous adenoid cystic carcinoma (PCACC) is a very rare malignancy. The differential diagnosis of PCACCs in pathology practice can be difficult and a group of primary and metastatic lesions, including adenoid basal cell carcinoma of the skin, should be considered in the differential diagnosis. Besides histomorphological clues, immunohistochemistry studies are very helpful in the differential diagnosis of PCACC. We report herein a case of PCACC with extensive immunohistochemical studies and review the literature from an immunohistochemistry perspective...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28238677/improving-public-awareness-of-multimorbidity
#18
EDITORIAL
Alessandra Marengoni, Laura Fratiglioni, Graziano Onder
No abstract text is available yet for this article.
February 23, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28238394/the-authors-respond-top-cited-articles-on-ultrasound-in-the-ed
#19
Başak Bayram, Önder Limon, Gülsüm Limon, Volkan Hancı
No abstract text is available yet for this article.
February 11, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28229356/symptoms-of-swallowing-anxiety-in-panic-disorder-patients-and-associated-psychopathologic-factors
#20
Ersin Budak, İbrahim Taymur, Sinay Önen, Bilgen Biçer Kanat, Önder Akdeniz, Hakan Demirci
AIM: The aim of this study was to investigate symptoms of swallowing difficulty in Panic Disorder (PD) patients and the factors associated with these symptoms. METHODS: In the pre-phase of the study, 22 PD patients who were treated in psychiatry outpatient clinics and who were found to have swallowing difficulty were evaluated. PD patients were asked to write about their thoughts, feelings and behaviors associated with swallowing difficulty. Later, these texts were examined and 41 expressions were identified in which patients described their swallowing difficulty...
February 22, 2017: Eating and Weight Disorders: EWD
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