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https://www.readbyqxmd.com/read/29042562/cis-p-tau-is-induced-in-clinical-and-preclinical-brain-injury-and-contributes-to-post-injury-sequelae
#1
Onder Albayram, Asami Kondo, Rebekah Mannix, Colin Smith, Cheng-Yu Tsai, Chenyu Li, Megan K Herbert, Jianhua Qiu, Michael Monuteaux, Jane Driver, Sandra Yan, William Gormley, Ava M Puccio, David O Okonkwo, Brandon Lucke-Wold, Julian Bailes, William Meehan, Mark Zeidel, Kun Ping Lu, Xiao Zhen Zhou
Traumatic brain injury (TBI) is characterized by acute neurological dysfunction and associated with the development of chronic traumatic encephalopathy (CTE) and Alzheimer's disease. We previously showed that cis phosphorylated tau (cis P-tau), but not the trans form, contributes to tau pathology and functional impairment in an animal model of severe TBI. Here we found that in human samples obtained post TBI due to a variety of causes, cis P-tau is induced in cortical axons and cerebrospinal fluid and positively correlates with axonal injury and clinical outcome...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29040474/co-occurrence-of-genes-for-aerobic-and-anaerobic-biodegradation-of-dichloroethane-in-organochlorine-contaminated-groundwater
#2
Jacob E Munro, Önder Kimyon, Deborah J Rich, Joanna Koenig, Sihui Tang, Adrian Low, Matthew Lee, Mike Manefield, Nicholas V Coleman
1,2-dichloroethane (DCA) is a problematic groundwater pollutant. Factors influencing the distribution and activities of DCA-degrading bacteria are not well-understood, which has hampered their application for bioremediation. Here, we used quantitative PCR (qPCR) to investigate the distribution of putative DCA-dehalogenating bacteria at a DCA-impacted site in Sydney (Australia). The dehalogenase genes dhlA, tceA and bvcA were detected in all groundwater samples (n = 15), while vcrA was found in 11/15 samples...
October 12, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29038859/refashioned-lamb-tissue-as-an-animal-model-for-training-complex-techniques-of-laryngotracheal-stenosis-surgery
#3
Lluís Nisa, Pedro Teiga, Gustavo Barreto da Cunha, Biswanath Roy, Riza Onder Gunaydin, Kishore Sandu
Open reconstructive upper airway surgery for laryngotracheal stenosis (LTS), whether for subglottic or tracheal stenosis, constitutes a group of complex approaches. LTS requiring open reconstruction is overall rare and primarily performed at tertiary centres. This poses an obvious challenge for the acquisition and maintenance of surgical skills for this group of complex approaches. In this context, animal models provide a unique opportunity for open reconstructive airway surgery training. Such models ought to take into consideration ethical aspects, be easily available and easy to maintain, and have similar macroscopic anatomical features to the human laryngotracheal frame...
October 16, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29032349/organizational-home-care-models-across-europe-a-cross-sectional-study
#4
Liza Van Eenoo, Henriëtte van der Roest, Graziano Onder, Harriet Finne-Soveri, Vjenka Garms-Homolova, Palmi V Jonsson, Stasja Draisma, Hein van Hout, Anja Declercq
BACKGROUND: Decision makers are searching for models to redesign home care and to organize health care in a more sustainable way. OBJECTIVES: The aim of this study is to identify and characterize home care models within and across European countries by means of structural characteristics and care processes at the policy and the organization level. DATA SOURCES: At the policy level, variables that reflected variation in health care policy were included based on a literature review on the home care policy for older persons in six European countries: Belgium, Finland, Germany, Iceland, Italy, and the Netherlands...
September 21, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29031989/chn1-gene-mutation-analysis-in-patients-with-duane-s-retraction-syndrome
#5
Elif Demirkilinc Biler, Orhan Ilim, Huseyin Onay, Onder Uretmen
PURPOSE: To investigate CHN1 (chimerin 1) gene mutations in patients with isolated nonsyndromic Duane syndrome and accompanying positive familial history, bilaterality, or various systemic disorders. METHODS: Patients with Duane retraction syndrome (DRS) and a positive family history of congenital ocular motility disturbance or bilateral involvement or accompanying any congenital disorder(s) seen consecutively at a single center from 2013 to 2016 were enrolled. All subjects underwent full ophthalmologic examination, including refraction, best-corrected visual acuity, ocular alignment and motility, globe retraction, and biomicroscopic or fundus evaluation...
October 12, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29031526/the-temporal-artery-island-flap-a-good-reconstructive-option-for-small-to-medium-sized-facial-defects
#6
Said Algan, Murat Kara, Hakan Cinal, Ensar Zafer Barin, Akin Inaloz, Onder Tan
PURPOSE: The reconstruction of facial defects is esthetically vital because of the unique skin color and texture of the face. The aim of this study was to show the utility of different temporal artery island flap designs for the reconstruction of upper and middle facial defects without contrast to the color and texture of the face. MATERIALS AND METHODS: This study is retrospective case series conducted from November 2004 through May 2015. Patients older than 18 years with upper and middle facial defects smaller than 5 cm were included...
September 19, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28984695/primary-cutaneous-cd8-t-cell-lymphoma-an-indolent-and-locally-aggressive-form-mimicking-paronychia
#7
Sarah M Beggs, Ben J Friedman, Davida Kornreich, Lauren Okon, Onder Alpdogan, Wenyin Shi, Joya Sahu
CD8 T-cell lymphomas comprise a wide spectrum of lymphomas, many which have yet to be formally classified. We present a case of a 43-year-old woman with an enlarging tumor distal to the distal interphalangeal joint of the fourth finger, compressing the underlying nail matrix. Magnetic resonance imaging showed bony involvement of the underlying distal phalanx. Histology showed a dense epidermotropic and pandermal infiltrate composed of medium-sized, uniformly pleomorphic lymphocytes with cleaved nuclei, which raised the possibility of primary cutaneous CD8 aggressive epidermotropic cytotoxic T-cell lymphoma...
September 28, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28975522/calcium-channel-blockers-in-secondary-cardiovascular-prevention-and-risk-of-acute-events-real-world-evidence-from-nested-case-control-studies-on-italian-hypertensive-elderly
#8
Alessandra Bettiol, Ersilia Lucenteforte, Alfredo Vannacci, Niccolò Lombardi, Graziano Onder, Nera Agabiti, Cristiana Vitale, Gianluca Trifirò, Giovanni Corrao, Giuseppe Roberto, Alessandro Mugelli, Alessandro Chinellato
BACKGROUND AND OBJECTIVES: Antihypertensive treatment with calcium channel blockers (CCBs) is consolidated in clinical practice; however, different studies observed increased risks of acute events for short-acting CCBs. This study aimed to provide real-world evidence on risks of acute cardiovascular (CV) events, hospitalizations and mortality among users of different CCB classes in secondary CV prevention. METHODS: Three case-control studies were nested in a cohort of Italian elderly hypertensive CV-compromised CCBs users...
October 3, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28971160/frontal-lobe-ischemic-stroke-presenting-with-peripheral-type-facial-palsy-a-crucial-diagnostic-challenge-in-emergency-practice
#9
Halil Onder, Levent Albayrak, Halil Polat
Here, we illustrate a 69-year old female admitting with weakness on left side of the face who firstly considered peripheral facial palsy in the forefront. However, detailed neurological examination and cranial MRI findings finally yielded the proper diagnosis of right hemisphere ischemic stroke. Via this remarkable presentation, we point out the clinical challenges in evaluation processes of patients with facial palsy in emergency practice and emphasize the importance of detailed examination for the proper diagnosis as well as initiation of appropriate treatment agents without delay...
September 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28967492/multimorbidity-care-model-recommendations-from-the-consensus-meeting-of-the-joint-action-on-chronic-diseases-and-promoting-healthy-ageing-across-the-life-cycle-ja-chrodis
#10
Katie Palmer, Alessandra Marengoni, Maria João Forjaz, Elena Jureviciene, Tiina Laatikainen, Federica Mammarella, Christiane Muth, Rokas Navickas, Alexandra Prados-Torres, Mieke Rijken, Ulrike Rothe, Laurène Souchet, Jose Valderas, Theodore Vontetsianos, Jelka Zaletel, Graziano Onder
Patients with multimorbidity have complex health needs but, due to the current traditional disease-oriented approach, they face a highly fragmented form of care that leads to inefficient, ineffective, and possibly harmful clinical interventions. There is limited evidence on available integrated and multidimensional care pathways for multimorbid patients. An expert consensus meeting was held to develop a framework for care of multimorbid patients that can be applied across Europe, within a project funded by the European Union; the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS)...
September 14, 2017: Health Policy
https://www.readbyqxmd.com/read/28966146/understanding-gene-functions-and-disease-mechanisms-phenotyping-pipelines-in-the-german-mouse-clinic
#11
REVIEW
Helmut Fuchs, Juan Antonio Aguilar-Pimentel, Oana V Amarie, Lore Becker, Julia Calzada-Wack, Yi-Li Cho, Lillian Garrett, Sabine M Hölter, Martin Irmler, Martin Kistler, Markus Kraiger, Philipp Mayer-Kuckuk, Kristin Moreth, Birgit Rathkolb, Jan Rozman, Patricia da Silva Buttkus, Irina Treise, Annemarie Zimprich, Kristine Gampe, Christine Hutterer, Stefanie Leuchtenberger, Holger Maier, Manuel Miller, Angelika Scheideler, Moya Wu, Johannes Beckers, Raffi Bekeredjian, Markus Brielmeier, Dirk H Busch, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Carsten Schmidt-Weber, Tobias Stoeger, Eckhard Wolf, Wolfgang Wurst, Ali Önder Yildirim, Andreas Zimmer, Valérie Gailus-Durner, Martin Hrabě de Angelis
Since decades, model organisms have provided an important approach for understanding the mechanistic basis of human diseases. The German Mouse Clinic (GMC) was the first phenotyping facility that established a collaboration-based platform for phenotype characterization of mouse lines. In order to address individual projects by a tailor-made phenotyping strategy, the GMC advanced in developing a series of pipelines with tests for the analysis of specific disease areas. For a general broad analysis, there is a screening pipeline that covers the key parameters for the most relevant disease areas...
September 28, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28959106/assesment-of-right-ventricle-function-with-speckle-tracking-echocardiography-after-the-percutaneous-closure-of-atrial-septal-defect
#12
Onder Ozturk, Unal Ozturk, Mehmet Zilkif Karahan
BACKGROUND: Transthoracic echocardiography is used for assessment of right ventricular (RV) function. Speckle tracking echocardiography (STE) is a new tool to assess myocardial function. The aim of this study was to evaluate RV function using STE in patients with atrial septal defect (ASD) before and the first month after percutaneous closure. METHODS: We prospectively examined 32 consecutive patients (9 male, 23 female) who underwent percutaneous transcatheter closure (PTC) of secundum ASD from June 2013 to December 2015...
September 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28957993/an-international-perspective-on-chronic-multimorbidity-approaching-the-elephant-in-the-room
#13
Davide L Vetrano, Amaia Calderón-Larrañaga, Alessandra Marengoni, Graziano Onder, Jürgen M Bauer, Matteo Cesari, Luigi Ferrucci, Laura Fratiglioni
Multimorbidity is a common and burdensome condition that may affect quality of life, increase medical needs and make people live more years of life with disability. Negative outcomes related to multimorbidity occur beyond what we would expect from the summed effect of single conditions, as chronic diseases interact with each other, mutually enhancing their negative effects, and eventually leading to new clinical phenotypes. Moreover, multimorbidity mirrors an accelerated global susceptibility and a loss of resilience, which are both hallmarks of aging...
September 16, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28957134/burst-mode-thulium-all-fiber-laser-delivering-femtosecond-pulses-at-a-1%C3%A2-%C3%A2-ghz-intra-burst-repetition-rate
#14
Parviz Elahi, Hamit Kalaycioğlu, Önder Akçaalan, Çağri Şenel, F Ömer Ilday
We report on the development of, to the best of our knowledge, the first ultrafast burst-mode laser system operating at a central wavelength of approximately 2 μm, where water absorption and, consequently, the absorption of most biological tissue is very high. The laser comprises a harmonically mode-locked 1-GHz oscillator, which, in turn, seeds a fiber amplifier chain. The amplifier produces 500 ns long bursts containing 500 pulses with 1 GHz intra-burst and 50 kHz inter-burst repetition rates, respectively, at an average power of 1 W, corresponding to 40 nJ pulse and 20 μJ burst energies, respectively...
October 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28946495/heterogeneous-sono-fenton-like-process-using-magnetic-cobalt-ferrite-reduced-graphene-oxide-cofe2o4-rgo-nanocomposite-for-the-removal-of-organic-dyes-from-aqueous-solution
#15
Aydin Hassani, Gülşah Çelikdağ, Paria Eghbali, Melike Sevim, Semra Karaca, Önder Metin
We report herein the synthesis of monodisperse cobalt ferrite (CoFe2O4) nanoparticles (NPs) via a surfactant-assisted high temperature thermal decomposition method and then their assembly on reduced graphene oxide (rGO) to yield CoFe2O4-rGO nanocomposites, which displayed outstanding sonocatalytic activity for the removal of organic dyes from aqueous solutions under ultrasonic irradiation. As-prepared CoFe2O4-rGO nanocomposites were characterized by using transmission electron microscopy (TEM), high-resolution scanning electron microscopy (HR-SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), Micro-Raman spectroscopy, Vibrating sample magnetometer (VSM) and inductively couple plasma mass spectrometer (ICP-MS)...
January 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28944341/laparoscopic-resection-for-meckel-s-diverticulum-causing-intestinal-obstruction
#16
Türker Karabuğa, İsmail Özsan, Ömer Yoldaş, Erkan Şahin, Önder Limon, Ünal Aydın
Meckel's diverticulum (MD) is the most common congenital anomaly of the gastrointestinal system with an estimated incidence of approximately 2% of the population. Although most cases are asymptomatic, it has the potential to create complications, such as hemorrhage, inflammation, intestinal obstruction, perforation, and intussusception. Meckel's diverticulum is generally diagnosed incidentally or upon investigation of unexplained gastrointestinal bleeding, perforation, inflammation, or obstruction for both pediatric and adult patients...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28941882/investigation-of-an-algorithm-for-anti-hcv-eia-reactivity-in-blood-donor-screening-in-turkey-in-the-absence-of-nucleic-acid-amplification-screening
#17
Ayse Esra Karakoc, Rukiye Berkem, Hasan Irmak, Ali Pekcan Demiroz, Idil Yenicesu, Nigar Ertugrul, Önder Arslan, Sabri Kemahli, Sevinc Yilmaz, Osman Ozcebe, Abdurrahman Kara, Gulsum Ozet, Ziya Cibali Acikgoz, Tulin Acikgoz
PURPOSE: In this study we aimed to propose an algorithm for initial anti HCV EIA reactive blood donations in Turkey where nucleic acid amplification tests are not yet obligatory for donor screening. METHODS: A total of 416 anti HCV screening test reactive donor samples collected from 13 blood centers from three cities in Turkey were tested in duplicate by Ortho HCV Ab Version 3.0 and Radim HCV Ab. All the repeat reactive samples were tested by INNO-LIA HCV Ab 3...
September 8, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28920539/the-effects-of-stabilization-splint-treatment-on-the-volume-of-masseter-muscle-in-sleep-bruxism-patients
#18
Suleyman Hakan Tuna, Osman Evren Celik, Onder Ozturk, Murat Golpinar, Aykut Aktas, Huseyin Avni Balcioglu, Filiz Keyf, Bunyamin Sahin
Objective The aim of this study was to evaluate, quantitatively, the volumetric effects of stabilization splint therapy on the masseter muscle of sleep bruxism (SB) patients. Methods The magnetic resonance (MR) images of 16 SB patients diagnosed by polysomnography (PSG) who used stabilization splints for four months were obtained before and after the therapy. The masseter muscle volume was calculated using Cavalieri's principle on the MR images. Results After the splint therapy, the mean volume of the masseter muscle did not reduce significantly...
September 18, 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28916023/beh%C3%A3-et-disease-new-aspects
#19
Isil Bulur, Meltem Onder
Behçet disease is currently considered an "autoinflammatory disease" triggered by infection and environmental factors in genetically predisposed individuals. Although the disease is characterized by recurrent oral and genital aphthous ulcers and ocular involvement, it can affect multiple organ systems. Complex aphthosis is characterized by recurrent oral and/or genital aphthous ulcers. It is important to evaluate the patient with complex aphthosis for Behçet disease and related systemic disorders. We discuss the etiopathogenesis, clinical features, diagnostic criteria, and treatment approaches for complex aphthosis and Behçet disease in light of the current literature...
September 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28898795/intestinal-perforation-that-developed-after-chemotherapy-in-a-patient-diagnosed-with-non-hodgkin-lymphoma-a-case-report-and-review-of-literature
#20
Cihad Tatar, Mazlum Yavas, Onder Akkus, Bahaeddin Tapkan, Oguz Kagan Batikan, Savas Bayrak, Soykan Arikan
INTRODUCTION: Non-Hodgkin Lymphomas (NHL) appear with the malign transformation of mature lymphocytes. Intestinal perforations are one of the most well-known complications of NHLs. In this review, a 29-year-old male patient who was diagnosed with NHL with gastrointestinal involvement that developed intestinal perforation after chemotherapy is presented. PRESENTATION OF CASE: A 29-year-old male patient who received systemic chemotherapy in another healthcare center due to Major B-Cell Lymphoma was examined because he had stomachache after the treatment...
September 2, 2017: International Journal of Surgery Case Reports
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