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https://www.readbyqxmd.com/read/29461377/total-lower-lip-reconstruction-with-functional-gracilis-free-muscle-flap
#1
Mehmet Akif Cakmak, Hakan Cinal, Ensar Zafer Barin, Muhammed Sedat Sakat, Harun Karaduman, Onder Tan
Free flaps based on static slings principles cannot provide esthetic and functional outcomes at a desired level in total or close to total lip loss. Therefore, dynamic methods have become a current issue in recent years and especially the idea of functional gracilis free muscle flap has been suggested. In this study, we present a case of a successful total lower lip repair with this flap.In a 78-year-old female patient who was diagnosed with squamous cell carcinoma involving the entire lower lip, bilateral modified radical neck dissection and full-thickness total resection with 1 cm surgical margin so as to include both commissures of the tumor were performed and then a free gracilis muscle flap was transferred from the same side...
February 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29456367/serial-diffusion-weighted-imaging-in-transient-global-amnesia
#2
Halil Onder
No abstract text is available yet for this article.
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29456365/dyspraxic-gait-due-to-right-posterior-cerebral-artery-stroke
#3
Halil Onder
No abstract text is available yet for this article.
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29453652/significance-of-the-nonneoplastic-renal-parenchymal-findings-in-robotic-partial-nephrectomy-series
#4
Ercan Malkoç, Matthew J Maurice, Oktay Akça, Önder Kara, Homayoun Zargar, Hiury Andrade, Daniel Ramirez, Peter Caputo, Robert Stein, Demirjian Sevag, Jihad H Kaouk
AIM: To describe the pathological characteristics of the peritumoral non-neoplastic renal parenchyma (NNRP) and to investigate their impact on long-term renal function after partial nephrectomy. MATERIALS AND METHODS: In our institutional robotic partial nephrectomy database, we identified 394 cases with pathological assessment of the NNRP and long-term postoperative renal functional follow-up. The NNRP was classified as normal (healthy renal parenchyma) or abnormal, based on the presence of arteriosclerosis, glomerulosclerosis, interstitial fibrosis, interstitial inflammation, and/or tubulopapillary hyperplasia...
February 16, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29451340/therapeutic-neural-stem-cells-engineered-during-different-stages-of-reprogramming-reveal-varying-therapeutic-efficacies
#5
Deepak Bhere, Rajiv Kumar Khajuria, William T Hendriks, Antara Bandyopadhyay, Tugba Bagci-Onder, Khalid Shah
Stem cells are emerging as promising treatment strategies for several brain disorders and pathologies including brain tumors. In this study, we explored the potential of creating induced pluripotent stem cell (iPSC) derived therapeutic NSCs (ipNSC) by using either unmodified or gene-modified somatic cells and tested their fate and therapeutic efficacies in vitro and in vivo. We show that cells engineered in somatic state lose transgene-expression during the neural induction process, which is partially restored by HDAC inhibitor (i) treatment whereas cells engineered at the ipNSC state have sustained expression of transgenes...
February 16, 2018: Stem Cells
https://www.readbyqxmd.com/read/29439264/innate-immunity-of-the-lung-from-basic-mechanisms-to-translational-medicine
#6
Dominik Hartl, Rabindra Tirouvanziam, Julie Laval, Catherine M Greene, David Habiel, Lokesh Sharma, Ali Önder Yildirim, Charles S Dela Cruz, Cory M Hogaboam
The respiratory tract is faced daily with 10,000 L of inhaled air. While the majority of air contains harmless environmental components, the pulmonary immune system also has to cope with harmful microbial or sterile threats and react rapidly to protect the host at this intimate barrier zone. The airways are endowed with a broad armamentarium of cellular and humoral host defense mechanisms, most of which belong to the innate arm of the immune system. The complex interplay between resident and infiltrating immune cells and secreted innate immune proteins shapes the outcome of host-pathogen, host-allergen, and host-particle interactions within the mucosal airway compartment...
February 13, 2018: Journal of Innate Immunity
https://www.readbyqxmd.com/read/29425306/interferon-treatment-duration-in-patients-with-chronic-delta-hepatitis-and-its-effect-on-the-natural-course-of-the-disease
#7
Cihan Yurdaydin, Onur Keskin, Çagdas Kalkan, Fatih Karakaya, Aysun Çaliskan, Gökhan Kabaçam, F Oguz Önder, Senem Karatayli, Ersin Karatayli, Xheni Deda, Hakan Bozkaya, A Mithat Bozdayi, Ramazan Idilman
Background: Interferon is the only treatment option in chronic delta hepatitis (CDH). A CDH database (333 patients, 161 with interferon treatment history) was analyzed for effects of treatment duration on virologic response and clinical outcomes. Methods: Ninety-nine CDH patients who received at least 6 months of interferon were selected. Maintained virologic response (MVR) was defined as hepatitis D virus RNA negative for 2 years after treatment discontinuation...
February 7, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29424696/upper-respiratory-viral-infections-in-patients-with-haematological-malignancies-after-allogeneic-haematopoietic-stem-cell-transplantation-a-retrospective-study
#8
Erden Atilla, Didem Sahin, Pinar Ataca Atilla, Istar Dolapci, Alper Tekeli, Sinem Civriz Bozdag, Meltem Kurt Yuksel, Selami Kocak Toprak, Osman Ilhan, Onder Arslan, Muhit Ozcan, Gunhan Gurman, Pervin Topcuoglu
BACKGROUND: Community respiratory viruses (CRVs) are associated with upper respiratory viral infections (URI), pneumonia or life-threatening respiratory disease in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our aim is to demonstrate our URI experience related to CRVs after allo-HSCT. METHODS: From January 2013 to November 2015, 39 post allo-HSCT patients with acute URI symptoms were included to the study. We evaluated CRVs by multiplex PCR from nasopharyngeal wash and throat swabs...
February 9, 2018: Antiviral Therapy
https://www.readbyqxmd.com/read/29420368/myofibroblastoma-of-the-breast-ultrasonography-mammography-and-magnetic-resonance-imaging-features-with-pathologic-correlation
#9
Ravza Yilmaz, Gulcin Akkavak, Eren Ozgur, Semen Onder, Enver Ozkurt, Memduh Dursun
Myofibroblastoma (MFB) of the breast is an uncommon benign stromal tumor. Herein, we present histopathologically proven MFB that hyperechoic well-defined breast mass in the ultrasonography and circumscribed high-density mass in mammography. Additionally, internal septations and hyperintense appearance on magnetic resonance imaging are very valuable findings in the differential diagnosis of MFB.
February 7, 2018: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29415120/impact-of-the-st101-clone-on-fatality-among-patients-with-colistin-resistant-klebsiella-pneumoniae-infection
#10
Fusun Can, Sirin Menekse, Pelin Ispir, Nazli Atac, Ozgur Albayrak, Tuana Demir, Doruk Can Karaaslan, Salih Nafiz Karahan, Mahir Kapmaz, Ozlem Kurt Azap, Funda Timurkaynak, Serap Simsek Yavuz, Seniha Basaran, Fugen Yoruk, Alpay Azap, Safiye Koculu, Nur Benzonana, Nathan A Lack, Mehmet Gönen, Onder Ergonul
Objectives: We describe the molecular characteristics of colistin resistance and its impact on patient mortality. Methods: A prospective cohort study was performed in seven different Turkish hospitals. The genotype of each isolate was determined by MLST and repetitive extragenic palindromic PCR (rep-PCR). Alterations in mgrB were detected by sequencing. Upregulation of pmrCAB, phoQ and pmrK was quantified by RT-PCR. mcr-1 and the genes encoding OXA-48, NDM-1 and KPC were amplified by PCR...
February 3, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29411310/polypharmacy-in-home-care-in-europe-cross-sectional-data-from-the-ibenc-study
#11
Silvia Giovannini, Henriëtte G van der Roest, Angelo Carfì, Harriet Finne-Soveri, Vjenka Garms-Homolová, Anja Declercq, Pálmi V Jónsson, Hein van Hout, Davide L Vetrano, Ester Manes Gravina, Roberto Bernabei, Graziano Onder
BACKGROUND: Home care (HC) patients are characterized by a high level of complexity, which is reflected by the prevalence of multimorbidity and the correlated high drug consumption. This study assesses prevalence and factors associated with polypharmacy in a sample of HC patients in Europe. METHODS: We conducted a cross-sectional analysis on 1873 HC patients from six European countries participating in the Identifying best practices for care-dependent elderly by Benchmarking Costs and outcomes of community care (IBenC) project...
February 6, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29404157/to-investigate-the-effects-of-air-pollution-pm10-and-so2-on-the-respiratory-diseases-asthma-and-chronic-obstructive-pulmonary-disease
#12
Mustafa Saygın, Taner Gonca, Önder Öztürk, Mehmet Has, Sadettin Çalışkan, Zehra Güliz Has, Ahmet Akkaya
OBJECTIVES: Effects of air pollution parameters of sulfur dioxide (SO2) and particulate matter (PM10) values on the respiratory system were investigated. MATERIAL AND METHODS: Data of SO2 and PM10 were obtained daily for air pollution and classified into two groups: Group I (2006-2007), coal burning years and Group II (2008-2009), natural gas+ coal burning. Groups I and II were divided into two subgroups according to the months of combustion as combustible (November-April) and noncombustible (May-October)...
April 2017: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29403011/clcn2-chloride-channel-mutations-in-familial-hyperaldosteronism-type-ii
#13
Ute I Scholl, Gabriel Stölting, Julia Schewe, Anne Thiel, Hua Tan, Carol Nelson-Williams, Alfred A Vichot, Sheng Chih Jin, Erin Loring, Verena Untiet, Taekyeong Yoo, Jungmin Choi, Shengxin Xu, Aihua Wu, Marieluise Kirchner, Philipp Mertins, Lars C Rump, Ali Mirza Onder, Cory Gamble, Daniel McKenney, Robert W Lash, Deborah P Jones, Gary Chune, Priscila Gagliardi, Murim Choi, Richard Gordon, Michael Stowasser, Christoph Fahlke, Richard P Lifton
Primary aldosteronism, a common cause of severe hypertension 1 , features constitutive production of the adrenal steroid aldosterone. We analyzed a multiplex family with familial hyperaldosteronism type II (FH-II) 2 and 80 additional probands with unsolved early-onset primary aldosteronism. Eight probands had novel heterozygous variants in CLCN2, including two de novo mutations and four independent occurrences of a mutation encoding an identical p.Arg172Gln substitution; all relatives with early-onset primary aldosteronism carried the CLCN2 variant found in the proband...
February 5, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29400834/high-power-yb-based-all-fiber-laser-delivering-300%C3%A2-%C3%A2-fs-pulses-for-high-speed-ablation-cooled-material-removal
#14
Parviz Elahi, Önder Akçaalan, Cansu Ertek, Koray Eken, F Ömer Ilday, Hamit Kalaycoğlu
We report on a 72 W Yb all-fiber ultrafast laser system with 1.6 GHz intra-burst and 200 kHz burst repetition rate developed to demonstrate ablation-cooled material removal at high speeds. Up to 24 W is applied on Cu and Si samples with pulses of ∼300  fs, and record-high ablation efficiencies are obtained, compared to published results to date, despite using only ∼100  nJ pulses. Ablation speeds approaching 1  mm3/s are reported with 24 W of average power, limited by available laser power and beam scanning speed...
February 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29396269/acidified-seawater-increases-accumulation-of-cobalt-but-not-cesium-in-manila-clam-ruditapes-philippinarum
#15
Narin Sezer, Hasan Oğuz Kocaoğlan, Önder Kılıç, Thomas Lacoue-Labarthe, Murat Belivermiş
The pH of seawater around the world is expected to continue its decline in the near future in response to ocean acidification that is driven by heightened atmospheric CO2 emissions. Concomitantly, economically-important molluscs that live in coastal waters including estuaries and embayments, may be exposed to a wide assortment of contaminants, including trace metals and radionuclides. Seawater acidification may alter both the chemical speciation of select elements as well as the physiology of organisms, and may thus pose at risk to many shellfish species, including the manila clam Ruditapes philippinarum...
January 31, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29396191/sarcopenia-in-parkinson-disease-comparison-of-different-criteria-and-association-with-disease-severity
#16
Davide L Vetrano, Maria S Pisciotta, Alice Laudisio, Maria R Lo Monaco, Graziano Onder, Vincenzo Brandi, Domenico Fusco, Beatrice Di Capua, Diego Ricciardi, Roberto Bernabei, Giuseppe Zuccalà
OBJECTIVES: In Parkinson disease (PD), sarcopenia may represent the common downstream pathway that from motor and nonmotor symptoms leads to the progressive loss of resilience, frailty, and disability. Here we (1) assessed the prevalence of sarcopenia in older adults with PD using 3 different criteria, testing their agreement, and (2) evaluated the association between PD severity and sarcopenia. DESIGN: Cross-sectional, observation study. SETTING: Geriatric day hospital...
January 30, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29392746/effect-of-sperm-pooling-with-seminal-plasma-collected-in-breeding-or-nonbreeding-season-on-saanen-goat-sperm-cryosurvival
#17
B Ustuner, E Gokce, M B Toker, N T Onder, M K Soylu, H Sagirkaya, Z Nur
The aim of this study was to determine the effects of both the removal of seminal plasma (SP) and the pre-freezing addition of seminal plasma collected during the breeding or nonbreeding season on goat sperm survival after thawing. Semen samples were pooled. One aliquot of pooled semen was used as a control group. Four aliquots were then centrifuged, and the SP was removed in Group I, pipetted but not removed in Group II, removed and then pooled for animals collected in the breeding season in Group III and removed and pooled for animals collected in the nonbreeding season in Group IV...
February 2, 2018: Andrologia
https://www.readbyqxmd.com/read/29391337/intracranial-bleeding-in-a-female-hemophilia-patient-molecular-analysis-of-factor-8-gene-and-determination-of-a-novel-mutation
#18
Burcak Tatlı Güneş, Zühal Önder Siviş, Eda Ataseven, Barış Malbora, Meral Türker, Burcu Fatma Belen, Berna Atabay, Tahir Atik, Esra Işık, Ferda Özkınay
No abstract text is available yet for this article.
February 2, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29391257/ccl19-producing-fibroblastic-stromal-cells-restrain-lung-carcinoma-growth-by-promoting-local-antitumor-t-cell-responses
#19
Hung-Wei Cheng, Lucas Onder, Jovana Cupovic, Maximilian Boesch, Mario Novkovic, Natalia Pikor, Ignazio Tarantino, Regulo Rodriguez, Tino Schneider, Wolfram Jochum, Martin Brutsche, Burkhard Ludewig
BACKGROUND: A particular characteristic of non-small cell lung cancer (NSCLC) is the composition of the tumor microenvironment with a very high proportion of fibroblastic stromal cells (FSC). OBJECTIVE: Lapses in our basic knowledge of fibroblast phenotype and function in the tumor microenvironment make it difficult to define whether FSC subsets exist that exhibit either tumor-promoting or tumor-suppressive properties. METHODS: We employed gene expression profiling of lung versus tumor FSC from NSCLC patients...
January 29, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29383397/nsaids-utilization-for-musculoskeletal-indications-in-elderly-patients-with-cerebro-cardiovascular-disease
#20
Giuseppe Roberto, Claudia Bartolini, Federico Rea, Graziano Onder, Cristiana Vitale, Gianluca Trifirò, Ursula Kirchmayer, Alessandro Chinellato, Ersilia Lucenteforte, Giovanni Corrao, Alessandro Mugelli, Francesco Lapi, Rosa Gini
OBJECTIVES: To describe NSAID utilization for musculoskeletal conditions in a large cohort of Italian elderly with cerebro/cardiovascular disease, a population in which NSAIDs should be generally avoided due to the prothrombotic potential. METHODS: Administrative data from five Italian geographic areas were analyzed. Patients aged ≥ 65 with a cerebro/cardiovascular event recorded between 2008 and 2011 (cohort entry) were selected. Prescription NSAIDs reimbursed for musculoskeletal conditions and dispensed during 1 year follow-up were retrieved to describe (i) prevalence of use, (ii) average amount of defined daily doses of NSAIDs claimed by users per day of follow-up, and (iii) distribution of the received daily dose (RDD) among patients with ≥ 2 dispensings...
January 30, 2018: European Journal of Clinical Pharmacology
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