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https://www.readbyqxmd.com/read/27920294/effects-of-increasing-the-affinity-of-card-for-rna-polymerase-on-mycobacterium-tuberculosis-growth-rrna-transcription-and-virulence
#1
Ashley L Garner, Jayan Rammohan, Jeremy P Huynh, Lucas M Onder, James Chen, Brian Bae, Drake Jensen, Leslie A Weiss, Ana Ruiz Manzano, Seth A Darst, Elizabeth A Campbell, Bryce E Nickels, Eric A Galburt, Christina L Stallings
: CarD is an essential RNA polymerase (RNAP) interacting protein in Mycobacterium tuberculosis (Mtb) that stimulates formation of RNAP-promoter open complexes. CarD plays a complex role in Mtb growth and virulence that is not fully understood. Therefore, to gain further insight into the role of CarD in Mtb growth and virulence we determined the effect of increasing the affinity of CarD for RNAP. Using site-directed mutagenesis guided by crystal structures of CarD bound to RNAP, we identified amino acid substitutions that increase the affinity of CarD for RNAP...
December 5, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27917800/laparoscopic-nissen-fundoplication-with-mesh-hiatoplasty-single-center-experience-and-early-term-results
#2
Mehmet Tolga Kafadar, Metin Yalaza, Ahmet Türkan, Önder Sürgit, Gürkan Değirmencioğlu, Işilay Nadir
PURPOSE: In this study we report early-term results of laparoscopic Nissen fundoplication with mesh hiatoplasty that we perform to treat gastroesophageal reflux disease. METHODS: We retrospectively reviewed the medical records of 68 patients who underwent laparoscopic Nissen fundoplication with mesh hiatoplasty at our clinic. Thirty-six (53%) patients were male and 32 (47%) were female. The mean age of the study population was 46.1 (25-72) years. All patients underwent endoscopy, esophagus pH metry and manometry before the operation...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27909612/nonsurgical-treatment-options-in-peyronie-s-disease-2016-update
#3
REVIEW
Raidh A Talib, Mohammed Abdulkareem Ibrahim, Önder Cangüven
Peyronie's disease (PD) is an inflammatory condition of penile tunica albuginea which commonly ends with penile curvature and difficulty in vaginal penetration. Unfortunately, the pathophysiology of PD has not been completely understood. In this paper, we will review what is known about the pathophysiology of PD and the nonsurgical medical treatment options that have been trialed as a result. In the last 5 years, commonly used oral medications left their places to intralesional therapies. Clostridium collagenase, which is the only Food and Drug Administration (FDA) approved treatment for PD, is now the most prescribed intralesional therapy in the last years...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27908685/royal-jelly-supplemented-soybean-lecithin-based-extenders-improve-post-thaw-quality-and-incubation-resilience-of-goat-spermatozoa
#4
Selim Alcay, M Berk Toker, N Tekin Onder, Elif Gokce
The aim of the present study was to evaluate different concentrations of royal jelly (RJ) supplemented extenders for post-thaw quality and incubation resilience of goat spermatozoa. Semen samples were collected from five goats. Pooled semen were diluted with soybean lecithin-based extender without RJ (control) or supplemented with different concentrations (0.25, 0.5 and 0.75%) of RJ (RJ0.25, RJ0.5, RJ0.75 respectively), at a final concentration of 150 × 10(6) spermatozoon/mL. Semen samples were assessed for sperm motility, plasma membrane integrity using hypoosmotic swelling test (HOST) damaged acrosome using FITC-Pisum sativum agglutinin (PSA-FITC) and DNA integrity using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)...
November 28, 2016: Cryobiology
https://www.readbyqxmd.com/read/27905574/reply-to-spontaneous-intracranial-hypotension-and-its-association-with-movement-disorders
#5
COMMENT
Richard Salazar
In Response To: Onder H. Spontaneous intracranial hypotension and its association with movement disorders? Tremor Other Hyperkinet Mov. 2016; 6. doi: 10.7916/D84B31NS Original Article: Salazar R. Spontaneous intracranial hypotension associated with kinetic tremor and ataxia. Tremor Other Hyperkinet Mov. 2016; 6. doi: 10.7916/D8HQ3ZN5.
2016: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/27905285/the-current-status-of-ticks-in-turkey-a-100-year-period-review-from-1916-to-2016
#6
Abdullah İnci, Alparslan Yıldırım, Önder Düzlü
Environmental and bio-ecological changes, some administrative and political mistakes, and global warming seriously affect the behaviors of ticks in Turkey and globally. The global public sensitivity toward tick infestations has increased along with increases in tick-borne diseases (TBDs). Recently, the World Health Organization (WHO) developed a new political concept, "One Health," for specific struggle strategies against tick infestations and TBDs. To highlight the importance of the issue, the WHO had declared the year 2015 for vector-borne diseases and adopted the slogan "small bites big threat"...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27904119/an-autopsy-case-of-amyotrophic-lateral-sclerosis-with-diaphragm-pacing
#7
Hisashi Ito, Tetsumasa Kamei, Sanae Odake, Masayuki Nakano, Riki Okeda, Shunsaku Kohriki, Jun Kawachi, Raymond P Onders, Fumihito Yoshii
Respiratory insufficiency is a critical problem in amyotrophic lateral sclerosis (ALS) patients. We herein present the case of an autopsied patient with sporadic ALS who underwent diaphragm pacing (DP). The pathology showed several localized adhesions with a markedly atrophied diaphragm. A marked loss of motor neurons with Bunina bodies and phosphorylated TDP-43 positive inclusions was found in the spinal cord and primary motor cortex. Mild hyalinization and a few multinucleated giant cells were present around the electrode tracks in the diaphragm...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27899416/peritoneal-dialysis-access-revision-in-children-causes-interventions-and-outcomes
#8
Dagmara Borzych-Duzalka, T Fazil Aki, Marta Azocar, Colin White, Elizabeth Harvey, Sevgi Mir, Marta Adragna, Erkin Serdaroglu, Rajiv Sinha, Charlotte Samaille, Juan Jose Vanegas, Jameela Kari, Lorena Barbosa, Arvind Bagga, Monica Galanti, Onder Yavascan, Giovanna Leozappa, Maria Szczepanska, Karel Vondrak, Kei-Chiu Tse, Franz Schaefer, Bradley A Warady
BACKGROUND AND OBJECTIVES: Little published information is available about access failure in children undergoing chronic peritoneal dialysis. Our objectives were to evaluate frequency, risk factors, interventions, and outcome of peritoneal dialysis access revision. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data were derived from 824 incident and 1629 prevalent patients from 105 pediatric nephrology centers enrolled in the International Pediatric Peritoneal Dialysis Network Registry between 2007 and 2015...
November 29, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27897276/spontaneous-intracranial-hypotension-and-its-association-with-movement-disorders
#9
Halil Onder
In Response To: Salazar R. Spontaneous intracranial hypotension associated with kinetic tremor and ataxia. Tremor Other Hyperkinet Mov. 2016; 6. doi: 10.7916/D8HQ3ZN5.
2016: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/27896834/histologic-alterations-in-tetralogy-of-fallot
#10
Safak Alpat, Mustafa Yilmaz, Sevgen Onder, Mustafa F Sargon, Murat Guvener, Riza Dogan, Metin Demircin, Ilhan Pasaoglu
BACKGROUND: This study was performed to investigate the pre-existing histologic alterations at the time of complete repair in patients with tetralogy of Fallot (TOF) and evaluate their effects on the early postoperative outcomes. METHODS: Fourteen patients, seven with acyanotic TOF (SO2  > 90, group I) and seven with cyanotic TOF (SO2  < 90, group II), undergoing complete repair, were enrolled. Right ventricular biopsies were examined for cardiomyocyte injury and fibrosis by light microscopy and mitochondrial injury by electron microscopy...
November 28, 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/27891558/erratum-to-an-experimental-study-on-the-comparison-of-the-effects-of-triester-glycerol-oxide-on-wound-repair
#11
Serhat Sezgin, Metin Sencimen, Aydin Gülses, Fevzi Erdemci, Mustafa Ayna, İsmail K Gider, Onder Ongoru, Tuncer Cayci
No abstract text is available yet for this article.
November 28, 2016: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27889406/is-surgeons-experience-important-on-intra-and-inter-observer-reliability-of-classifications-used-for-adult-femoral-neck-fracture
#12
Ali Turgut, Mert Kumbaracı, Önder Kalenderer, Gökhan İlyas, Tayfun Bacaksız, Levent Karapınar
PURPOSE: To evaluate whether surgeons' experience affect inter- and intra-observer reliability among mostly used classification systems for femoral neck fractures. MATERIAL AND METHODS: A power point presentation was prepared with 107 slides which were antero-posterior radiographs of each femoral neck fracture. Five residents, 5 orthopaedic surgeons and 5 senior orthopaedic surgeons reviewed this presentation and classified the fractures according to Garden, Pauwels and AO classifications...
November 23, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27881027/is-robotic-partial-nephrectomy-safe-for-t3a-renal-cell-carcinoma-experience-of-a-high-volume-center
#13
Hiury S Andrade, Homayoun Zargar, Oktay Akca, Önder Kara, Peter Caputo, Daniel Ramirez, Guillermo Andres, Robert J Stein, Shih-Chieh J Chueh, Jihad Kaouk
PURPOSE: To compare the oncological and functional outcomes of robotic partial nephrectomy (RPN) with radical nephrectomy (RN) in RCC cases with pT3a staging. PATIENTS AND METHODS: A retrospective analysis of our IRB approved nephrectomy database from 2005 to 2015 was performed. RPN and RN cases with confirmed RCC and pT3a staging were matched. Preoperative variables, functional and oncological outcomes were compared between the groups, as well a Kaplan-Meier estimated overall survival (OS), cancer specific survival (CSS) and recurrence-free survival (RFS)...
November 23, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27879227/correlation-between-cvemp-and-abr-for-the-evaluation-of-vestibular-migraine
#14
Mehmet Sürmeli, Reyhan Sürmeli, İldem Deveci, Serap Önder, Ayşe Destina Yalçın, Çağatay Oysu
OBJECTIVE: Vestibular migraine (VM) is a clinical condition characterized by temporal overlap between vestibular symptoms and migraine. In this study, we aimed to determine the changes in vestibular myogenic potential (cVEMP) and auditory brainstem response (ABR) in patients with VM and migraine. MATERIALS AND METHODS: A total of 86 participants with no hearing loss or additional disease between the ages of 18 and 45 were enrolled in three different groups: group 1, VM; group 2, migraine without aura; and group 3, healthy controls...
November 23, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27876213/the-impact-of-methotrexate-on-lung-inflammatory-and-apoptotic-pathway-biomarkers-the-role-of-gallic-acid
#15
Mustafa Saygin, Onder Ozturk, Ozlem Ozmen, Ilter Ilhan, Taner Gonca, Nurhan Gumral, Hikmet Orhan, Rahime Aslankoc
BACKGROUNDS: The aim of this study was to investigate the effects of methotrexate (MTX) on the lung via inflammatory and apoptotic pathway biomarkers and the role of gallic acid (GA). METHODS: In this study, twenty four male Wistar-Albino rats weighing 300-350g were divided into 3 groups as follows; Control group (0.1ml/oral saline, for 7 days+2nd day i.p.). MTX group (20mg/kg, single dose, on 2nd day). MTX+GA group (15mg/kg, orally, for 7 days). Comet analysis, oxidant-antioxidant status, IMA were conducted...
November 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27876042/the-effect-of-screw-thread-length-on-initial-stability-of-schatzker-type-1-tibial-plateau-fracture-fixation-a-biomechanical-study
#16
Ahmet Salduz, Fevzi Birisik, Gokhan Polat, Bugra Bekler, Ergun Bozdag, Onder Kilicoglu
BACKGROUND: This study compares the cyclic loading properties and failure loads of two screw combinations on a synthetic Schatzker type 1 tibia fracture model. Our hypothesis was that after adequate compression with first a partially threaded screw, addition of a fully threaded screw would provide more stability than an addition of a second partially threaded screw. METHODS: The Schatzker type 1 tibial plateau fracture model was created. Fixation was obtained in group A (n = 10) with two partially threaded screws and in group B (n = 10) with one fully threaded screw and one partially threaded screw...
November 22, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27868320/predictors-of-rehospitalization-among-older-adults-results-of-the-crime-study
#17
Federica Sganga, Francesco Landi, Stefano Volpato, Antonio Cherubini, Carmelinda Ruggiero, Andrea Corsonello, Paolo Fabbietti, Fabrizia Lattanzio, Ester Manes Gravina, Roberto Bernabei, Graziano Onder
AIM: To assess the predictors of readmission among older adults hospitalized in acute care wards. METHODS: A prospective cohort study was carried out among 921 hospitalized older adults participating in the CRiteria to Assess Appropriate Medication Use among Elderly Complex Patients (CRIME) project. The primary outcome of the study was rehospitalization within 1 year after discharge from acute care hospitals. We assessed the participants with a questionnaire including 350 items about demographic, social and clinical characteristics...
November 21, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27862784/does-being-assisted-by-care-workers-affect-antipsychotics-prescription-among-older-people-discharged-from-hospital
#18
Mirko Di Rosa, Paolo Fabbietti, Andrea Corsonello, Sergio Fusco, Federica Sganga, Stefano Volpato, Carmelinda Ruggiero, Graziano Onder, Fabrizia Lattanzio
AIM: Several factors can affect antipsychotic prescriptions, among which, caregivers. However, whether being assisted by a care worker might increase the rate of antipsychotic prescriptions at discharge from acute care hospital has not been previously investigated. We aimed to investigate whether being assisted by a care worker is associated with increased use of antipsychotics among older patients discharged from acute care hospitals. METHODS: The present series consisted of 928 patients not taking antipsychotics at admission in seven acute care wards of geriatric medicine in Italy (mean age 80...
November 10, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27857984/the-effect-of-patient-qualifications-and-number-of-patient-accompanist-on-patient-s-satisfaction
#19
Tanzer Korkmaz, Burcin Balaban, Husnu Onder, Fusun Saricil
OBJECTIVES: Patient satisfaction surveys are important information sources for the evaluation of the quality and continuity of medical care. In this study, it is aimed to investigate the impact of patient's qualifications and the number of patient accompanists on the patient satisfaction and to find out whether there is a relationship between the number of patient accompanist and discharge status of patient. METHODS: All patients over 18 years old who have applied to emergency department within one month, along with the relevant patient information were recorded...
September 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27849325/how-safe-is-the-semi-sterile-technique-in-the-percutaneous-pinning-of-supracondylar-humerus-fractures
#20
Ali Turgut, Burak Önvural, Cemal Kazımoğlu, Tayfun Bacaksız, Önder Kalenderer, Haluk Ağuş
BACKGROUND: The purpose of the present study was to evaluate safety and efficiency of the semi-sterile technique used in recent years in treatment of pediatric supracondylar humeral fractures (SHF). METHODS: Total of 712 patients who were treated for SHF via closed reduction and percutaneous fixation with semi-sterile technique were enrolled in present study. Patients were evaluated for postoperative infection and other complications. Clinical and radiological assessments were also made...
September 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
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