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https://www.readbyqxmd.com/read/28107525/longitudinal-testing-of-olfactory-and-gustatory-function-in-patients-with-multiple-sclerosis
#1
Florian Cornelius Uecker, Heidi Olze, Hagen Kunte, Christian Gerz, Önder Göktas, Lutz Harms, Felix Alexander Schmidt
BACKGROUND: The aim of the study was to investigate changes of the olfactory and gustatory capacity in patients with multiple sclerosis (MS). METHODOLOGY: 20 MS patients were tested longitudinally for 3 years after initial testing. The Threshold Discrimination Identification test (TDI) was used for subjective olfactometry. Objective olfactometry was performed by registering olfactory evoked potentials (OEP) by EEG. The Taste Strip Test (TST) was used for gustatory testing...
2017: PloS One
https://www.readbyqxmd.com/read/28104359/todd-s-paralysis-a-crucial-entity-masquerading-stroke-in-the-emergency-department
#2
Halil Onder
No abstract text is available yet for this article.
January 16, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28093274/a-direct-quantitative-pcr-based-measurement-of-herpes-simplex-virus-susceptibility-to-antiviral-drugs-and-neutralizing-antibodies
#3
Dezső P Virók, Ildikó Eszik, Tímea Mosolygó, Kamil Önder, Valéria Endrész, Katalin Burián
Herpes simplex viruses (HSV) are common human pathogens that can cause painful but benign manifestations and recurrent complaints, but can also cause significant morbidity and mortality on infection of the eye or brain and with disseminated infection of an immunosuppressed patient or a neonate. HSV growth inhibition measurement by plaque or yield reduction is a key task in the development of novel antiviral compounds but the manual methods are very labour intensive. The sensitive and specific PCR technology could be an effective method for quantitation of HSV DNA related to virus replication; however the currently described PCR approaches have a major limitation, namely the requirement of purification of DNA from the infected cells...
January 16, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28091388/blood-meal-identification-of-the-mosquito-diptera-culicidae-specimens-belong-to-culex-pipiens-complex-that-were-collected-from-kayseri-province
#4
Seval Korkmaz, Alparslan Yıldırım, Önder Düzlü, Arif Çiloğlu, Zuhal Önder, Abdullah İnci
OBJECTIVE: This study aimed to determine the host preferences in blood meal of specimens belonging to Culex pipiens complex. METHODS: A total of 1284 female mosquitos were morphologically examined, and genomic DNA isolations were individually performed on 376 (28.4%) specimens that were determined to be Cx. pipiens complex. PCR was performed with primers to specifically amplify the avian and mammalian mitochondrial cytochrome b (mt-cytb) gene region. Amplicons were cloned, and the obtained plasmids were sequenced to determine host species...
December 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/28087299/when-partial-nephrectomy-is-unsuccessful-understanding-the-reasons-for-conversion-from-robotic-partial-to-radical-nephrectomy-at-a-tertiary-referral-center
#5
Önder Kara, Matthew J Maurice, Pascal Mouracade, Ercan Malkoç, Julien Dagenais, Ryan J Nelson, Jaya Sai Chavali, Robert J Stein, Amr Fergany, Jihad H Kaouk
OBJECTIVE: To identify the preoperative factors associated with conversion from robotic partial nephrectomy (RPN) to radical nephrectomy (RN), and to report the incidence of this event. PATIENTS AND METHODS: Using our institutional review board-approved database, we abstracted data on 1023 RPN cases performed at our center between 2010 and 2015. Standard and converted cases were compared in terms of patients and tumor characteristics and perioperative, functional, and oncological outcomes...
January 10, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28081349/chrysin-prevents-brain-damage-caused-by-global-cerebralischemia-reperfusion-in-a-c57bl-j6-mouse-model
#6
Mehmet Akif Durak, Mustafa Namık Öztanır, Neşe Başak Türkmen, Osman Çiftçi, Aslı Taşlıdere, Mehmet Tecellioğlu, Arif Önder
BACKGROUND/AIM: The present study investigated the neuroprotective effects of chrysin (CRS) following global cerebral ischemia and reperfusion (I/R) in a C57BL/J6 mouse model. MATERIALS AND METHODS: A total of 40 mice were equally divided into four groups: (1) sham-operated (SH = control), (2) global cerebral I/R (I/R), (3) CRS, and (4) CRS + I/R. In the I/R group, the bilateral carotid arteries were clipped for 15 min and the mice were treated with vehicle (corn oil) for 10 days...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28079299/a-platinum-blue-complex-exerts-its-cytotoxic-activity-via-dna-damage-and-induces-apoptosis-in-cancer-cells
#7
Zelal Adiguzel, Seniz Ozalp-Yaman, Gokalp Celik, Safia Salem, Tugba Bagci-Onder, Filiz Senbabaoglu, Yüksel Cetin, Ceyda Acilan
Here, we describe the characteristics of a Pt-blue complex [Pt4 (2-atp)8 (H2 O)(OH)] (2-atp: 2-aminothiophenol) as a prodrug for its DNA-binding properties and its use in cancer therapy. The nature of the interaction between the Pt-blue complex and DNA was evaluated based on spectroscopic measurements, the electronic absorption spectra, thermal behavior, viscosity, fluorometric titration and agarose gel electrophoresis. Our results suggested that the compound was able to partially intercalate DNA and appeared to induce both single and double stranded breaks (DBS) on DNA in vitro, but no DSBs in cells...
January 12, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28074679/vitamin-d-treatment-improves-levels-of-sexual-hormones-metabolic-parameters-and-erectile-function-in-middle-aged-vitamin-d-deficient-men
#8
Onder Canguven, Raidh A Talib, Walid El Ansari, Dany-Jan Yassin, Abdullah Al Naimi
BACKGROUND: The associations between serum vitamin D (VD), serum testosterone (TT) and metabolic syndrome are complex and with limited published research, particularly on the effects of VD treatment on sexual hormones, erectile function and the metabolic syndrome. OBJECTIVES: This study assessed whether a monthly high dose VD treatment for 12 months in VD deficient middle-aged men was associated with: changes in levels of sexual hormones, improvement of diabetes control and metabolic syndrome components, better erectile function [International Index of Erectile Function (IIEF)-5 questionnaire]; and changes in a prostate marker...
January 11, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28062383/intra-articular-osteoid-osteoma-in-the-ischial-spine-of-a-5-year-old-child
#9
Mustafa Kemal Demir, Onder Ofluoglu
No abstract text is available yet for this article.
January 3, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28049617/synthesis-of-antimicrobial-glucosamides-as-bacterial-quorum-sensing-mechanism-inhibitors
#10
Nripendra N Biswas, Tsz Tin Yu, Önder Kimyon, Shashidhar Nizalapur, Christopher R Gardner, Mike Manefield, Renate Griffith, David StC Black, Naresh Kumar
Bacteria communicate with one another and regulate their pathogenicity through a phenomenon known as quorum sensing (QS). When the bacterial colony reaches a threshold density, the QS system induces the production of virulence factors and the formation of biofilms, a powerful defence system against the host's immune responses. The glucosamine monomer has been shown to disrupt the bacterial QS system by inhibiting autoinducer (AI) signalling molecules such as the acyl-homoserine lactones (AHLs). In this study, the synthesis of acetoxy-glucosamides 8, hydroxy-glucosamides 9 and 3-oxo-glucosamides 12 was performed via the 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC·HCl) and N,N'-dicyclohexylcarbodiimide (DCC) coupling methods...
December 21, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28045421/cardiovascular-diseases-and-vehicle-driving-the-proposal-of-turkish-society-of-cardiology-2016
#11
Mahmut Şahin, Önder Öztürk, Metin Çoksevim
The rate of traffic accidents due to medical causes is unknown. Based on data from Canada and the United States, cardiovascular conditions account for less than 5% of commercial vehicle accidents. European data shows that about 0.1% of reportable road accidents maybe attributed to medical conditions, of which 10-25% is due to cardiac events. Driving guidelines and regulations in cardiovascular diseases are of importance, not only for protecting the health of the patients but also for protection of the community...
December 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28039696/ginseng-and-cancer
#12
Ahmet Unlu, Erdinc Nayir, Onder Kirca, Hale Ay, Mustafa Ozdogan
Derived from the Greek word Panacea that means 'cure for all', Ginseng (Panax) has had an important place in Chinese Medicine for many of years. As the name suggests, it is believed to be a miraculous plant effective in the treatment of many health problems. It is claimed to have many effects such as sedative, hypnotic, aphrodisiac, antidepressant, diuretic, and stimulating effects, and to be effective in the treatment of certain health problems such as diabetes, Alzheimer's disease, erectile dysfunction and infections...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28033190/modified-superior-based-pharyngeal-flap-is-effective-in-treatment-of-velopharyngeal-insufficiency-regardless-of-the-preoperative-closure-pattern
#13
Omer Ekin, Mert Calis, Mavis Emel Kulak Kayikci, Mehtap Icen, Riza Onder Gunaydin, Figen Ozgur
Velopharyngeal insufficiency (VPI) is certainly one of the most important problems confronted after cleft palate repairs. In this study, it was aimed to evaluate the preoperative and postoperative speaking results of patients who underwent modified superior-based pharyngeal flap. Sixty-six children who underwent modified superiorly based pharyngeal flap for treatment of VPI between 2005 and 2013 were retrospectively reviewed. The study population was evaluated in 2 distinctive groups depending on their preoperative velopharyngeal closure pattern as: coronal closure pattern or noncoronal closure patterns (ie, circular, sagittal with or without the presence of a Passavant ridge)...
December 28, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28018088/fracture-of-the-scapholunate-coalition
#14
Önder Yeniçeri, Nesat Cullu, Halil Beydilli, Mehmet Deveer, Rabia Mihriban Kilinc
No abstract text is available yet for this article.
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28003375/assessing-and-measuring-chronic-multimorbidity-in-the-older-population-a-proposal-for-its-operationalization
#15
Amaia Calderón-Larrañaga, Davide L Vetrano, Graziano Onder, Luis A Gimeno-Feliu, Carlos Coscollar-Santaliestra, Angelo Carfí, Maria S Pisciotta, Sara Angleman, René J F Melis, Giola Santoni, Francesca Mangialasche, Debora Rizzuto, Anna-Karin Welmer, Roberto Bernabei, Alexandra Prados-Torres, Alessandra Marengoni, Laura Fratiglioni
BACKGROUND: Although the definition of multimorbidity as "the simultaneous presence of two or more chronic diseases" is well established, its operationalization is not yet agreed. This study aims to provide a clinically driven comprehensive list of chronic conditions to be included when measuring multimorbidity. METHODS: Based on a consensus definition of chronic disease, all four-digit level codes from the International Classification of Diseases, 10th revision (ICD-10) were classified as chronic or not by an international and multidisciplinary team...
December 21, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28000156/predicting-the-risk-of-adverse-drug-reactions-in-older-inpatients-external-validation-of-the-gerontonet-adr-risk-score-using-the-crime-cohort
#16
Mirko Petrovic, Balamurugan Tangiisuran, Chakravarthi Rajkumar, Tischa van der Cammen, Graziano Onder
BACKGROUND: Adverse drug reactions (ADRs) in older people are often preventable, indicating that screening and prevention programs aimed at reducing their rate are needed in this population. OBJECTIVE: The aim of this study was to externally validate the GerontoNet ADR risk score and to assess its validity in specific subpopulations of older inpatients. METHODS: Data from the prospective CRIteria to assess appropriate Medication use among Elderly complex patients (CRIME) cohort were used...
December 20, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27995131/total-particulate-matter-concentration-skews-cigarette-smoke-s-gene-expression-profile
#17
Anna Dvorkin-Gheva, Gilles Vanderstocken, Ali Önder Yildirim, Corry-Anke Brandsma, Ma'en Obeidat, Yohan Bossé, John A Hassell, Martin R Stampfli
Exposure of small animals to cigarette smoke is widely used as a model to study the pathogenesis of chronic obstructive pulmonary disease. However, protocols and exposure systems utilised vary substantially and it is unclear how these different systems compare. We analysed the gene expression profile of six publically available murine datasets from different cigarette smoke-exposure systems and related the gene signatures to three clinical cohorts. 234 genes significantly regulated by cigarette smoke in at least one model were used to construct a 55-gene network containing 17 clusters...
October 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27994926/intraarticular-giant-size-angiolipoma-of-the-knee-causing-lateral-patellar-dislocation
#18
Gökhan İlyas, Ali Turgut, Duygu Ayaz, Önder Kalenderer
BACKGROUND: Angiolipomas are benign tumors usually seen in patients during their 2(nd) and 3(rd) decades. The subcutaneous region of the trunk, neck and extremities are the places where they generally settle. There is only one case report on angiolipoma in the knee joint that was resected by arthroscopic procedure in the English literature. CASE REPORT: We present a case of a giant-size multilobular non-infiltrating angiolipoma, extending outside of the right knee joint and causing lateral patellar dislocation in a thirteen-year-old boy...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27993666/patterns-and-predictors-of-recurrence-after-partial-nephrectomy-for-kidney-tumors
#19
Pascal Mouracade, Onder Kara, Matthew J Maurice, Julien Dagenais, Ercan Malkoc, Ryan J Nelson, Jihad H Kaouk
PURPOSE: To identify patterns and predictors of recurrence in patients with clinically localized renal cell carcinoma (CLRCC) managed with partial nephrectomy (PN). MATERIALS AND METHODS: Retrospective study of 830 consecutive cases of PN done between 2007 and 2015 for CLRCC at a single institution. Patient demographics, and pathological characteristics were correlated with recurrence patterns (overall, local and distant) and overall survival (OS) using Kaplan-Meier and cox regression analyses...
December 16, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27991852/epithelial-magnesium-transport-by-trpm6-is-essential-for-prenatal-development-and-adult-survival
#20
Vladimir Chubanov, Silvia Ferioli, Annika Wisnowsky, David G Simmons, Christin Leitzinger, Claudia Einer, Wenke Jonas, Yuriy Shymkiv, Harald Bartsch, Attila Braun, Banu Akdogan, Lorenz Mittermeier, Ludmila Sytik, Friedrich Torben, Vindi Jurinovic, Emiel Pc van der Vorst, Christian Weber, Önder A Yildirim, Karl Sotlar, Annette Schürmann, Susanna Zierler, Hans Zischka, Alexey G Ryazanov, Thomas Gudermann
Mg(2+) regulates many physiological processes and signalling pathways. However, little is known about the mechanisms underlying the organismal balance of Mg(2+). Capitalizing on a set of newly generated mouse models, we provide an integrated mechanistic model of the regulation of organismal Mg(2+) balance during prenatal development and in adult mice by the ion channel TRPM6. We show that TRPM6 activity in the placenta and yolk sac is essential for embryonic development. In adult mice, TRPM6 is required in the intestine to maintain organismal Mg(2+) balance, but is dispensable in the kidney...
December 19, 2016: ELife
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